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3. Evaluation of the interest to combine a CD4 Th1-inducer cancer vaccine derived from telomerase and atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma: a randomized non-comparative phase II study (TERTIO – PRODIGE 82)

Author

Vienot, Angélique, Jacquin, Marion, Rebucci-Peixoto, Magali, Pureur, Dimitri, Ghiringhelli, François, Assenat, Eric, Hammel, Pascal, Rosmorduc, Olivier, Stouvenot, Morgane, Allaire, Manon, Bouattour, Mohamed, Regnault, Hélène, Fratte, Serge, Raymond, Eric, Soularue, Emilie, Husson-Wetzel, Stéphanie, Di Martino, Vincent, Muller, Allison, Clairet, Anne-Laure, Fagnoni-Legat, Christine, Adotevi, Olivier, Meurisse, Aurélia, Vernerey, Dewi, and Borg, Christophe

Published
2023
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4. Differential acclimation kinetics of the two forms of type IV chromatic acclimaters occurring in marine Synechococcus cyanobacteria

Author

Louison Dufour, Laurence Garczarek, Bastian Gouriou, Julia Clairet, Morgane Ratin, and Frédéric Partensky

Subjects
marine picocyanobacteria, Synechococcus, chromatic acclimation, spectral niche, phycobilisome, comparative physiology, Microbiology, QR1-502
Abstract

Synechococcus, the second most abundant marine phytoplanktonic organism, displays the widest variety of pigment content of all marine oxyphototrophs, explaining its ability to colonize all spectral niches occurring in the upper lit layer of oceans. Seven Synechococcus pigment types (PTs) have been described so far based on the phycobiliprotein composition and chromophorylation of their light-harvesting complexes, called phycobilisomes. The most elaborate and abundant PT (3d) in the open ocean consists of cells capable of type IV chromatic acclimation (CA4), i.e., to reversibly modify the ratio of the blue light-absorbing phycourobilin (PUB) to the green light-absorbing phycoerythrobilin (PEB) in phycobilisome rods to match the ambient light color. Two genetically distinct types of chromatic acclimaters, so-called PTs 3dA and 3dB, occur at similar global abundance in the ocean, but the precise physiological differences between these two types and the reasons for their complementary niche partitioning in the field remain obscure. Here, photoacclimation experiments in different mixes of blue and green light of representatives of these two PTs demonstrated that they differ by the ratio of blue-to-green light required to trigger the CA4 process. Furthermore, shift experiments between 100% blue and 100% green light, and vice-versa, revealed significant discrepancies between the acclimation pace of the two types of chromatic acclimaters. This study provides novel insights into the finely tuned adaptation mechanisms used by Synechococcus cells to colonize the whole underwater light field.

Published
2024
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5. Evaluation of the interest to combine a CD4 Th1-inducer cancer vaccine derived from telomerase and atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma: a randomized non-comparative phase II study (TERTIO – PRODIGE 82)

Author

Angélique Vienot, Marion Jacquin, Magali Rebucci-Peixoto, Dimitri Pureur, François Ghiringhelli, Eric Assenat, Pascal Hammel, Olivier Rosmorduc, Morgane Stouvenot, Manon Allaire, Mohamed Bouattour, Hélène Regnault, Serge Fratte, Eric Raymond, Emilie Soularue, Stéphanie Husson-Wetzel, Vincent Di Martino, Allison Muller, Anne-Laure Clairet, Christine Fagnoni-Legat, Olivier Adotevi, Aurélia Meurisse, Dewi Vernerey, and Christophe Borg

Subjects
Hepatocellular carcinoma, Immunotherapy, Vaccination, Telomerase, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Several cancer immunotherapies that target the PD-L1/PD-1 pathway show promising clinical activity in patients with hepatocellular carcinoma (HCC). However, the standard of care in first-line treatment with atezolizumab (anti-PD-L1 therapy) in combination with bevacizumab is associated with a limited objective response rate. Telomerase reverse transcriptase (TERT) activation meets the criteria of oncogenic addiction in HCC and could be actionable therapeutic target and a relevant tumor antigen. Therefore we hypothesized that combining anti-PD-1/PD-L1 therapy with an anti-telomerase vaccine might be an attractive therapy in HCC. UCPVax is a therapeutic cancer vaccine composed of two separate peptides derived from telomerase (human TERT). UCPVax has been evaluated in a multicenter phase I/II study in non–small cell lung cancers and has demonstrated to be safe and immunogenic, and is under evaluation in combination with atezolizumab in a phase II clinical trial in tumors where telomerase reactivation contributes to an oncogene addiction (HPV+ cancers). The aim of the TERTIO study is to determine the clinical interest and immunological efficacy of a treatment combining the CD4 helper T-inducer cancer anti-telomerase vaccine (UCPVax) with atezolizumab and bevacizumab in unresectable HCC in a multicenter randomized phase II study. Methods Patients with locally advanced, metastatic or unresectable HCC who have not previously received systemic anti-cancer treatment are eligible. The primary end point is the objective response rate at 6 months. Patients will be allocated to a treatment arm with a randomization 2:1. In both arms, patients will receive atezolizumab at fixed dose of 1200 mg IV infusion and bevacizumab at fixed dose of 15 mg/kg IV infusion, every 3 weeks, according to the standard of care. In the experimental arm, these treatments will be combined with the UCPVax vaccine at 0.5 mg subcutaneously. Discussion Combining anti-PD-1/PD-L1 therapy with an anti-telomerase vaccine gains serious consideration in HCC, in order to extend the clinical efficacy of anti-PD-1/PD-L1. Indeed, anti-cancer vaccines can induce tumor-specific T cell expansion and activation and therefore restore the cancer-immunity cycle in patients lacking pre-existing anti-tumor responses. Thus, there is a strong rational to combine immune checkpoint blockade therapy and anticancer vaccine (UCPVax) in order to activate antitumor T cell immunity and bypass the immunosuppression in the tumor microenvironment in HCC. This pivotal proof of concept study will evaluate the efficacy and safety of the combination of a CD4 Th1-inducer cancer vaccine derived from telomerase (UCPVax) and atezolizumab plus bevacizumab in unresectable HCC, as well as confirming their synergic mechanism, and settling the basis for a new combination for future clinical trials. Trial registration NCT05528952.

Published
2023
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7. WEST full tungsten operation with an ITER grade divertor

Author

J. Bucalossi, A. Ekedahl, and the WEST Team, J. Achard, K. Afonin, O. Agullo, T. Alarcon, L. Allegretti, F. Almuhisen, H. Ancher, G. Antar, Y. Anquetin, S. Antusch, V. Anzallo, C. Arnas, J.F. Artaud, M.H. Aumeunier, S.G. Baek, X.Y. Bai, M. Balden, C. Balorin, T. Barbui, A. Barbuti, J. Barlerin, J. Barra, V. Basiuk, T. Batal, O. Baulaigue, A. Bec, M. Becoulet, E. Benoit, E. Bernard, J.M. Bernard, M. Bernert, N. Bertelli, E. Bertrand, P. Beyer, J. Bielecki, P. Bienvenu, R. Bisson, B. Bliewert, G. Bodner, S. Bose, C. Bottereau, C. Bouchand, Y. Boumendjel, F. Bouquey, C. Bourdelle, J. Bourg, S. Brezinsek, F. Brochard, C. Brun, V. Bruno, H. Bufferand, A. Bureau, S. Burles, Y. Camenen, B. Cantone, E. Caprin, M. Carole, S. Carpentier-Chouchana, G. Caulier, F. Causa, N. Cazanave, N. Chanet, O. Chellai, Y. Chen, M. Chernyshova, P. Chmielewski, W. Choe, A. Chomiczewska, G. Ciraolo, F. Clairet, J. Coenen, L. Colas, G. Colledani, J. Colnel, P. Coquillat, E. Corbel, Y. Corre, X. Courtois, T. Czarski, A. Da Ros, R. Daniel, J. Daumas, M. De Combarieu, P. De Vries, C. Dechelle, F. Deguara, R. Dejarnac, J.M. Delaplanche, L.F. Delgado-Aparicio, E. Delmas, L. Delpech, C. Desgranges, P. Devynck, J. Denis, S. Di Genova, R. Diab, A. Diallo, M. Diez, G. Dif-Pradalier, M. Dimitrova, R. Ding, T. Dittmar, L. Doceul, M. Domenes, D. Donovan, D. Douai, L. Dubus, N. Dumas, R. Dumont, F. Durand, A. Durif, F. Durodié, D. Elbeze, S. Ertmer, A. Escarguel, F. Escourbiac, B. Esposito, K. Ezato, F. Faisse, J.L. Farjon, N. Faure, N. Fedorczak, P. Fejoz, F. Felici, C. Fenzi-Bonizec, F. Ferlay, L. Ferrand, L. Fevre, M. Firdaouss, L. Fleury, D. Flouquet, T. Fonghetti, A. Gallo, X. Garbet, J. Garcia, J.L. Gardarein, L. Gargiulo, P. Garibaldi, S. Garitta, J. Gaspar, E. Gauthier, S. Gazzotti, F. Gely, J. Gerardin, G. Gervasini, E. Geulin, M. Geynet, P. Ghendrih, I. Giacalone, C. Gil, S. Ginoux, S. Girard, E. Giroux, G. Giruzzi, M. Goniche, V. Gorse, T. Gray, E. Grelier, C. Grisolia, A. Grosjean, A. Grosman, O. Grover, D. Guibert, D. Guilhem, C. Guillemaut, B. Guillermin, R. Guirlet, J.P. Gunn, Y. Gunsu, T. Gyergyek, S. Hacquin, A. Hakola, J. Harris, J.C. Hatchressian, W. Helou, P. Hennequin, C. Hernandez, L. Hijazi, J. Hillairet, T. Hirai, G.T. Hoang, C. Honoré, M. Houry, A. Huart, G. Huijsmans, P. Huynh, M. Iafrati, F. Imbeaux, N. Imbert, I. Ivanova-Stanik, P. Ivanova, R. Jalageas, A. Jamann, C. Jammes, A. Jardin, L. Jaubert, G. Jiolat, E. Joffrin, C. Johnson, A. Jonas, A. Kirschner, C.C. Klepper, M. Komm, M. Koubiti, S. Kosslow, J. Kovacic, M. Kozeiha, K. Krieger, K. Krol, I. Kudashev, B. Lacroix, L. Laguardia, V. Lamaison, V. Lapleigne, H. Laqua, C. Lau, Y. Lausenaz, R. Lé, M. Le Bohec, N. Lefevre, N. Lemoine, E. Lerche, Y. Lesourd, L. Letellier, M. Lewerentz, Y. Li, A. Liang, P. Linczuk, C. Linsmeier, M. Lipa, X. Litaudon, X. Liu, J. Llorens, T. Loarer, A. Loarte, T. Loewenhoff, G. Lombard, J. Lore, P. Lorenzetto, B. Lu, A. Lumsdaine, R. Lunsford, T. Lunt, G. Luo, P. Magaud, P. Maget, J.F. Mahieu, P. Maini, P. Malard, K. Malinowski, P. Manas, L. Manenc, V. Maquet, Y. Marandet, C. Martin, E.J. Martin, P. Martino, M. Mayer, D. Mazon, S. Mazzi, P. Messina, L. Meunier, D. Midou, G. Miglionico, Y. Mineo, M. Missirlian, R. Mitteau, B. Mitu, D. Moiraf, P. Mollard, G. Momparler, V. Moncada, T. Mondiere, C. Monti, J. Morales, M. Moreau, Ph. Moreau, Y. Moudden, G. Moureau, D. Mouyon, M. Muraglia, T. Nakano, E. Nardon, A. Neff, F. Nespoli, J. Nichols, L. Nicolas, S. Nicollet, R. Nouailletas, M. Ono, V. Ostuni, O. Paillat, C. Parish, H. Park, H. Parrat, J.Y. Pascal, B. Pegourie, F.P. Pellissier, Y. Peneliau, M. Peret, E. Pignoly, G. Pintsuk, R. Pitts, C. Pocheau, A. Podolnik, C. Portafaix, M. Poulos, P. Prochet, A. Puig Sitjes, R. Ragona, M. Rasinski, S. Ratynskaia, G. Raup, X. Regal-Mezin, C. Reux, J. Rice, M. Richou, F. Rigollet, N. Rivals, H. Roche, S. Rodrigues, J. Romazanov, G. Ronchi, C. Ruset, R. Sabot, A. Saille, R. Sakamoto, B. Salamon, F. Samaille, A. Santagiustina, B. Santraine, Y. Sarazin, O. Sauter, Y. Savoie-Peysson, L. Schiesko, M. Scholz, J.L. Schwob, E. Serre, H. Shin, S. Shiraiwa, Ja. Signoret, O. Skalli-Fettachi, P. Sogorb, Y. Song, A. Spring, P. Spuig, S. Sridhar, B. Stratton, C. Talatizi, P. Tamain, R. Tatali, Q. Tichit, A. Torre, L. Toulouse, W. Treutterer, E. Tsitrone, E.A. Unterberg, G. Urbanczyk, G. Van Rooij, N. Varadarajan, S. Vartanian, E. Velly, J.M. Verger, L. Vermare, D. Vezinet, N. Vignal, B. Vincent, S. Vives, D. Volpe, G. Wallace, E. Wang, L. Wang, Y. Wang, Y.S. Wang, T. Wauters, D. Weldon, B. Wirth, M. Wirtz, A. Wojenski, M. Xu, Q.X. Yang, H. Yang, B. Zago, R. Zagorski, B. Zhang, X.J. Zhang, X.L. Zou, and the EUROfusion Tokamak Exploitation Team

Subjects
nuclear fusion, magnetic confinement, tokamak, divertor, WEST, ITER, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

The mission of WEST (tungsten-W Environment in Steady-state Tokamak) is to explore long pulse operation in a full tungsten (W) environment for preparing next-step fusion devices (ITER and DEMO) with a focus on testing the ITER actively cooled W divertor in tokamak conditions. Following the successful completion of phase 1 (2016-2021), phase 2 started in December 2022 with the lower divertor made entirely of actively cooled ITER-grade tungsten mono-blocks. A boronization prior the first plasma attempt allowed for a smooth startup with the new divertor. Despite the reduced operating window due to tungsten, rapid progress has been made in long pulse operation, resulting in discharges with a pulse length of 100 s and an injected energy of around 300 MJ per discharge. Plasma startup studies were carried out with equatorial boron nitride limiters to compare them with tungsten limiters, while Ion Cyclotron Resonance Heating assisted startup was attempted. High fluence operation in attached regime, which was the main thrust of the first campaigns, already showed the progressive build up of deposits and appearance of dust, impacting the plasma operation as the plasma fluence increased. In total, the cumulated injected energy during the first campaigns reached 43 GJ and the cumulated plasma time exceeded 5 h. Demonstration of controlled X-Point Radiator regime is also reported, opening a promising route for investigating plasma exhaust and plasma-wall interaction issues in more detached regime. This paper summarises the lessons learned from the manufacturing and the first operation of the ITER-grade divertor, describing the progress achieved in optimising operation in a full W environment with a focus on long pulse operation and plasma wall interaction.

Published
2024
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8. Overview of ASDEX upgrade results in view of ITER and DEMO

Author

H. Zohm, E. Alessi, C. Angioni, N. Arden, V. Artigues, M. Astrain, O. Asunta, M. Balden, V. Bandaru, A. Banon Navarro, M. Bauer, A. Bergmann, M. Bergmann, J. Bernardo, M. Bernert, A. Biancalani, R. Bielajew, R. Bilato, G. Birkenmeier, T. Blanken, V. Bobkov, A. Bock, L. Bock, T. Body, T. Bolzonella, N. Bonanomi, A. Bortolon, B. Böswirth, C. Bottereau, A. Bottino, H. van den Brand, M. Brenzke, S. Brezinsek, D. Brida, F. Brochard, J. Buchanan, A. Buhler, A. Burckhart, Y. Camenen, B. Cannas, P. Cano Megías, D. Carlton, M. Carr, P. Carvalho, C. Castaldo, A. Castillo Castillo, A. Cathey, M. Cavedon, C. Cazzaniga, C. Challis, A. Chankin, A. Chomiczewska, C. Cianfarani, F. Clairet, S. Coda, R. Coelho, J.W. Coenen, L. Colas, G. Conway, S. Costea, D. Coster, T. Cote, A.J. Creely, G. Croci, D.J. Cruz Zabala, G. Cseh, I. Cziegler, O. D’Arcangelo, A. Dal Molin, P. David, C. Day, M. de Baar, P. de Marné, R. Delogu, P. Denner, A. Di Siena, M. Dibon, J.J. Dominguez-Palacios Durán, D. Dunai, M. Dreval, M. Dunne, B.P. Duval, R. Dux, T. Eich, S. Elgeti, A. Encheva, B. Esposito, E. Fable, M. Faitsch, D. Fajardo Jimenez, U. Fantz, M. Farnik, H. Faugel, F. Felici, O. Ficker, A. Figueredo, R. Fischer, O. Ford, L. Frassinetti, M. Fröschle, G. Fuchert, J.C. Fuchs, H. Fünfgelder, S. Futatani, K. Galazka, J. Galdon-Quiroga, D. Gallart Escolà, A. Gallo, Y. Gao, S. Garavaglia, M. Garcia Muñoz, B. Geiger, L. Giannone, S. Gibson, L. Gil, E. Giovannozzi, I. Girka, O. Girka, T. Gleiter, S. Glöggler, M. Gobbin, J.C. Gonzalez, J. Gonzalez Martin, T. Goodman, G. Gorini, T. Görler, D. Gradic, G. Granucci, A. Gräter, G. Grenfell, H. Greuner, M. Griener, M. Groth, O. Grover, A. Gude, L. Guimarais, S. Günter, D. Hachmeister, A.H. Hakola, C. Ham, T. Happel, N. den Harder, G. Harrer, J. Harrison, V. Hauer, T. Hayward-Schneider, B. Heinemann, P. Heinrich, T. Hellsten, S. Henderson, P. Hennequin, M. Herschel, S. Heuraux, A. Herrmann, E. Heyn, F. Hitzler, J. Hobirk, K. Höfler, S. Hörmann, J.H. Holm, M. Hölzl, C. Hopf, L. Horvath, T. Höschen, A. Houben, A. Hubbard, A. Huber, K. Hunger, V. Igochine, M. Iliasova, J. Illerhaus, K. Insulander Björk, C. Ionita-Schrittwieser, I. Ivanova-Stanik, S. Jachmich, W. Jacob, N. Jaksic, A. Jansen van Vuuren, F. Jaulmes, F. Jenko, T. Jensen, E. Joffrin, A. Kallenbach, J. Kalis, A. Kappatou, J. Karhunen, C.-P. Käsemann, S. Kasilov, Y. Kazakov, A. Kendl, W. Kernbichler, E. Khilkevitch, M. Kircher, A. Kirk, S. Kjer Hansen, V. Klevarova, F. Klossek, G. Kocsis, M. Koleva, M. Komm, M. Kong, A. Krämer-Flecken, M. Krause, I. Krebs, A. Kreuzeder, K. Krieger, O. Kudlacek, D. Kulla, T. Kurki-Suonio, B. Kurzan, B. Labit, K. Lackner, F. Laggner, A. Lahtinen, P. Lainer, P.T. Lang, P. Lauber, M. Lehnen, L. Leppin, E. Lerche, N. Leuthold, L. Li, J. Likonen, O. Linder, H. Lindl, B. Lipschultz, Y. Liu, Z. Lu, T. Luda Di Cortemiglia, N.C. Luhmann, T. Lunt, A. Lyssoivan, T. Maceina, J. Madsen, A. Magnanimo, H. Maier, J. Mailloux, R. Maingi, O. Maj, E. Maljaars, V. Maquet, A. Mancini, A. Manhard, P. Mantica, M. Mantsinen, P. Manz, M. Maraschek, C. Marchetto, M. Markl, L. Marrelli, P. Martin, F. Matos, M. Mayer, P.J. McCarthy, R. McDermott, G. Meng, R. Merkel, A. Merle, H. Meyer, M. Michelini, D. Milanesio, V. Mitterauer, P. Molina Cabrera, M. Muraca, F. Nabais, V. Naulin, R. Nazikian, R.D. Nem, R. Neu, A.H. Nielsen, S.K. Nielsen, T. Nishizawa, M. Nocente, I. Novikau, S. Nowak, R. Ochoukov, J. Olsen, P. Oyola, O. Pan, G. Papp, A. Pau, G. Pautasso, C. Paz-Soldan, M. Peglau, E. Peluso, P. Petersson, C. Piron, U. Plank, B. Plaum, B. Plöckl, V. Plyusnin, G. Pokol, E. Poli, A. Popa, L. Porte, J. Puchmayr, T. Pütterich, L. Radovanovic, M. Ramisch, J. Rasmussen, G. Ratta, S. Ratynskaia, G. Raupp, A. Redl, D. Réfy, M. Reich, F. Reimold, D. Reiser, M. Reisner, D. Reiter, B. Rettino, T. Ribeiro, D. Ricci, R. Riedl, J. Riesch, J.F. Rivero Rodriguez, G. Rocchi, P. Rodriguez-Fernandez, V. Rohde, G. Ronchi, M. Rott, M. Rubel, D.A. Ryan, F. Ryter, S. Saarelma, M. Salewski, A. Salmi, O. Samoylov, L. Sanchis Sanchez, J. Santos, O. Sauter, G. Schall, A. Schlüter, J. Scholte, K. Schmid, O. Schmitz, P.A. Schneider, R. Schrittwieser, M. Schubert, C. Schuster, N. Schwarz, T. Schwarz-Selinger, J. Schweinzer, F. Sciortino, O. Seibold-Benjak, A. Shabbir, A. Shalpegin, S. Sharapov, U. Sheikh, A. Shevelev, G. Sias, M. Siccinio, B. Sieglin, A. Sigalov, A. Silva, C. Silva, D. Silvagni, J. Simpson, S. Sipilä, A. Snicker, E. Solano, C. Sommariva, C. Sozzi, M. Spacek, G. Spizzo, M. Spolaore, A. Stegmeir, M. Stejner, D. Stieglitz, J. Stober, U. Stroth, E. Strumberger, G. Suarez Lopez, W. Suttrop, T. Szepesi, B. Tál, T. Tala, W. Tang, G. Tardini, M. Tardocchi, D. Terranova, M. Teschke, E. Thorén, W. Tierens, D. Told, W. Treutterer, G. Trevisan, M. Tripský, P. Ulbl, G. Urbanczyk, M. Usoltseva, M. Valisa, M. Valovic, S. van Mulders, M. van Zeeland, F. Vannini, B. Vanovac, P. Varela, S. Varoutis, T. Verdier, G. Verdoolaege, N. Vianello, J. Vicente, T. Vierle, E. Viezzer, I. Voitsekhovitch, U. von Toussaint, D. Wagner, X. Wang, M. Weiland, D. Wendler, A.E. White, M. Willensdorfer, B. Wiringer, M. Wischmeier, R. Wolf, E. Wolfrum, Q. Yang, C. Yoo, Q. Yu, R. Zagórski, I. Zammuto, T. Zehetbauer, W. Zhang, W. Zholobenko, A. Zibrov, M. Zilker, C.F.B. Zimmermann, A. Zito, S. Zoletnik, the EUROfusion Tokamak Exploitation Team, and the ASDEX Upgrade Team

Subjects
tokamak, MHD stability, transport modelling, radiative exhaust, disruption physics, ELM free scenarios, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Experiments on ASDEX Upgrade (AUG) in 2021 and 2022 have addressed a number of critical issues for ITER and EU DEMO. A major objective of the AUG programme is to shed light on the underlying physics of confinement, stability, and plasma exhaust in order to allow reliable extrapolation of results obtained on present day machines to these reactor-grade devices. Concerning pedestal physics, the mitigation of edge localised modes (ELMs) using resonant magnetic perturbations (RMPs) was found to be consistent with a reduction of the linear peeling-ballooning stability threshold due to the helical deformation of the plasma. Conversely, ELM suppression by RMPs is ascribed to an increased pedestal transport that keeps the plasma away from this boundary. Candidates for this increased transport are locally enhanced turbulence and a locked magnetic island in the pedestal. The enhanced D-alpha (EDA) and quasi-continuous exhaust (QCE) regimes have been established as promising ELM-free scenarios. Here, the pressure gradient at the foot of the H-mode pedestal is reduced by a quasi-coherent mode, consistent with violation of the high-n ballooning mode stability limit there. This is suggestive that the EDA and QCE regimes have a common underlying physics origin. In the area of transport physics, full radius models for both L- and H-modes have been developed. These models predict energy confinement in AUG better than the commonly used global scaling laws, representing a large step towards the goal of predictive capability. A new momentum transport analysis framework has been developed that provides access to the intrinsic torque in the plasma core. In the field of exhaust, the X-Point Radiator (XPR), a cold and dense plasma region on closed flux surfaces close to the X-point, was described by an analytical model that provides an understanding of its formation as well as its stability, i.e., the conditions under which it transitions into a deleterious MARFE with the potential to result in a disruptive termination. With the XPR close to the divertor target, a new detached divertor concept, the compact radiative divertor, was developed. Here, the exhaust power is radiated before reaching the target, allowing close proximity of the X-point to the target. No limitations by the shallow field line angle due to the large flux expansion were observed, and sufficient compression of neutral density was demonstrated. With respect to the pumping of non-recycling impurities, the divertor enrichment was found to mainly depend on the ionisation energy of the impurity under consideration. In the area of MHD physics, analysis of the hot plasma core motion in sawtooth crashes showed good agreement with nonlinear 2-fluid simulations. This indicates that the fast reconnection observed in these events is adequately described including the pressure gradient and the electron inertia in the parallel Ohm’s law. Concerning disruption physics, a shattered pellet injection system was installed in collaboration with the ITER International Organisation. Thanks to the ability to vary the shard size distribution independently of the injection velocity, as well as its impurity admixture, it was possible to tailor the current quench rate, which is an important requirement for future large devices such as ITER. Progress was also made modelling the force reduction of VDEs induced by massive gas injection on AUG. The H-mode density limit was characterised in terms of safe operational space with a newly developed active feedback control method that allowed the stability boundary to be probed several times within a single discharge without inducing a disruptive termination. Regarding integrated operation scenarios, the role of density peaking in the confinement of the ITER baseline scenario (high plasma current) was clarified. The usual energy confinement scaling ITER98( p,y ) does not capture this effect, but the more recent H20 scaling does, highlighting again the importance of developing adequate physics based models. Advanced tokamak scenarios, aiming at large non-inductive current fraction due to non-standard profiles of the safety factor in combination with high normalised plasma pressure were studied with a focus on their access conditions. A method to guide the approach of the targeted safety factor profiles was developed, and the conditions for achieving good confinement were clarified. Based on this, two types of advanced scenarios (‘hybrid’ and ‘elevated’ q -profile) were established on AUG and characterised concerning their plasma performance.

Published
2024
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9. Overview of the EUROfusion Tokamak Exploitation programme in support of ITER and DEMO

Author

E. Joffrin, M. Wischmeier, M. Baruzzo, A. Hakola, A. Kappatou, D. Keeling, B. Labit, E. Tsitrone, N. Vianello, the ASDEX Upgrade Team, JET Contributors, the MAST-U Team, the TCV Team, the WEST Team, the EUROfusion Tokamak Exploitation Team:, D. Abate, J. Adamek, M. Agostini, C. Albert, F.C.P. Albert Devasagayam, S. Aleiferis, E. Alessi, J. Alhage, S. Allan, J. Allcock, M. Alonzo, G. Anastasiou, E. Andersson Sunden, C. Angioni, Y. Anquetin, L. Appel, G.M. Apruzzese, M. Ariola, C. Arnas, J.F. Artaud, W. Arter, O. Asztalos, L. Aucone, M.H. Aumeunier, F. Auriemma, J. Ayllon, E. Aymerich, A. Baciero, F. Bagnato, L. Bähner, F. Bairaktaris, P. Balázs, L. Balbinot, I. Balboa, M. Balden, A. Balestri, M. Baquero Ruiz, T. Barberis, C. Barcellona, O. Bardsley, S. Benkadda, T. Bensadon, E. Bernard, M. Bernert, H. Betar, R. Bianchetti Morales, J. Bielecki, R. Bilato, P. Bilkova, W. Bin, G. Birkenmeier, R. Bisson, P. Blanchard, A. Bleasdale, V. Bobkov, A. Boboc, A. Bock, K. Bogar, P. Bohm, T. Bolzonella, F. Bombarda, N. Bonanomi, L. Boncagni, D. Bonfiglio, R. Bonifetto, M. Bonotto, D. Borodin, I. Borodkina, T.O.S.J. Bosman, C. Bourdelle, C. Bowman, S. Brezinsek, D. Brida, F. Brochard, R. Brunet, D. Brunetti, V. Bruno, R. Buchholz, J. Buermans, H. Bufferand, P. Buratti, A. Burckhart, J. Cai, R. Calado, J. Caloud, S. Cancelli, F. Cani, B. Cannas, M. Cappelli, S. Carcangiu, A. Cardinali, S. Carli, D. Carnevale, M. Carole, M. Carpita, D. Carralero, F. Caruggi, I.S. Carvalho, I. Casiraghi, A. Casolari, F.J. Casson, C. Castaldo, A. Cathey, F. Causa, J. Cavalier, M. Cavedon, J. Cazabonne, M. Cecconello, L. Ceelen, A. Celora, J. Cerovsky, C.D. Challis, R. Chandra, A. Chankin, B. Chapman, H. Chen, M. Chernyshova, A.G. Chiariello, P. Chmielewski, A. Chomiczewska, C. Cianfarani, G. Ciraolo, J. Citrin, F. Clairet, S. Coda, R. Coelho, J.W. Coenen, I.H. Coffey, C. Colandrea, L. Colas, S. Conroy, C. Contre, N.J. Conway, L. Cordaro, Y. Corre, D. Costa, S. Costea, D. Coster, X. Courtois, C. Cowley, T. Craciunescu, G. Croci, A.M. Croitoru, K. Crombe, D.J. Cruz Zabala, G. Cseh, T. Czarski, A. Da Ros, A. Dal Molin, M. Dalla Rosa, Y. Damizia, O. D’Arcangelo, P. David, M. De Angeli, E. De la Cal, E. De La Luna, G. De Tommasi, J. Decker, R. Dejarnac, D. Del Sarto, G. Derks, C. Desgranges, P. Devynck, S. Di Genova, L.E. di Grazia, A. Di Siena, M. Dicorato, M. Diez, M. Dimitrova, T. Dittmar, L. Dittrich, J.J. Domínguez Palacios Durán, P. Donnel, D. Douai, S. Dowson, S. Doyle, M. Dreval, P. Drews, L. Dubus, R. Dumont, D. Dunai, M. Dunne, A. Durif, F. Durodie, G. Durr Legoupil Nicoud, B. Duval, R. Dux, T. Eich, A. Ekedahl, S. Elmore, G. Ericsson, J. Eriksson, B. Eriksson, F. Eriksson, S. Ertmer, A. Escarguel, B. Esposito, T. Estrada, E. Fable, M. Faitsch, N. Fakhrayi Mofrad, A. Fanni, T. Farley, M. Farník, N. Fedorczak, F. Felici, X. Feng, J. Ferreira, D. Ferreira, N. Ferron, O. Fevrier, O. Ficker, A.R. Field, A. Figueiredo, N. Fil, D. Fiorucci, M. Firdaouss, R. Fischer, M. Fitzgerald, M. Flebbe, M. Fontana, J. Fontdecaba Climent, A. Frank, E. Fransson, L. Frassinetti, D. Frigione, S. Futatani, R. Futtersack, S. Gabriellini, D. Gadariya, D. Galassi, K. Galazka, J. Galdon, S. Galeani, D. Gallart, A. Gallo, C. Galperti, M. Gambrioli, S. Garavaglia, J. Garcia, M. Garcia Munoz, J. Gardarein, L. Garzotti, J. Gaspar, R. Gatto, P. Gaudio, M. Gelfusa, J. Gerardin, S.N. Gerasimov, R. Gerru Miguelanez, G. Gervasini, Z. Ghani, F.M. Ghezzi, G. Ghillardi, L. Giannone, S. Gibson, L. Gil, A. Gillgren, E. Giovannozzi, C. Giroud, G. Giruzzi, T. Gleiter, M. Gobbin, V. Goloborodko, A. González Ganzábal, T. Goodman, V. Gopakumar, G. Gorini, T. Görler, S. Gorno, G. Granucci, D. Greenhouse, G. Grenfell, M. Griener, W. Gromelski, M. Groth, O. Grover, M. Gruca, A. Gude, C. Guillemaut, R. Guirlet, J. Gunn, T. Gyergyek, L. Hagg, J. Hall, C.J. Ham, M. Hamed, T. Happel, G. Harrer, J. Harrison, D. Harting, N.C. Hawkes, P. Heinrich, S. Henderson, P. Hennequin, R. Henriques, S. Heuraux, J. Hidalgo Salaverri, J. Hillairet, J.C. Hillesheim, A. Hjalmarsson, A. Ho, J. Hobirk, E. Hodille, M. Hölzl, M. Hoppe, J. Horacek, N. Horsten, L. Horvath, M. Houry, K. Hromasova, J. Huang, Z. Huang, A. Huber, E. Huett, P. Huynh, A. Iantchenko, M. Imrisek, P. Innocente, C. Ionita Schrittwieser, H. Isliker, P. Ivanova, I. Ivanova Stanik, M. Jablczynska, S. Jachmich, A.S. Jacobsen, P. Jacquet, A. Jansen van Vuuren, A. Jardin, H. Järleblad, A. Järvinen, F. Jaulmes, T. Jensen, I. Jepu, S. Jessica, T. Johnson, A. Juven, J. Kalis, J. Karhunen, R. Karimov, A.N. Karpushov, S. Kasilov, Y. Kazakov, P.V. Kazantzidis, W. Kernbichler, HT. Kim, D.B. King, V.G. Kiptily, A. Kirjasuo, K.K. Kirov, A. Kirschner, A. Kit, T. Kiviniemi, F. Kjær, E. Klinkby, A. Knieps, U. Knoche, M. Kochan, F. Köchl, G. Kocsis, J.T.W. Koenders, L. Kogan, Y. Kolesnichenko, Y. Kominis, M. Komm, M. Kong, B. Kool, S.B. Korsholm, D. Kos, M. Koubiti, J. Kovacic, Y. Kovtun, E. Kowalska Strzeciwilk, K. Koziol, M. Kozulia, A. Krämer Flecken, A. Kreter, K. Krieger, U. Kruezi, O. Krutkin, O. Kudlacek, U. Kumar, H. Kumpulainen, M.H. Kushoro, R. Kwiatkowski, M. La Matina, M. Lacquaniti, L. Laguardia, P. Lainer, P. Lang, M. Larsen, E. Laszynska, K.D. Lawson, A. Lazaros, E. Lazzaro, M.Y.K. Lee, S. Leerink, M. Lehnen, M. Lennholm, E. Lerche, Y. Liang, A. Lier, J. Likonen, O. Linder, B. Lipschultz, A. Listopad, X. Litaudon, E. Litherland Smith, D. Liuzza, T. Loarer, P.J. Lomas, J. Lombardo, N. Lonigro, R. Lorenzini, C. Lowry, T. Luda di Cortemiglia, A. Ludvig Osipov, T. Lunt, V. Lutsenko, E. Macusova, R. Mäenpää, P. Maget, C.F. Maggi, J. Mailloux, S. Makarov, K. Malinowski, P. Manas, A. Mancini, D. Mancini, P. Mantica, M. Mantsinen, J. Manyer, M. Maraschek, G. Marceca, G. Marcer, C. Marchetto, S. Marchioni, A. Mariani, M. Marin, M. Markl, T. Markovic, D. Marocco, S. Marsden, L. Martellucci, P. Martin, C. Martin, F. Martinelli, L. Martinelli, J.R. Martin Solis, R. Martone, M. Maslov, R. Masocco, M. Mattei, G.F. Matthews, D. Matveev, E. Matveeva, M.L. Mayoral, D. Mazon, S. Mazzi, C. Mazzotta, G. McArdle, R. McDermott, K. McKay, A.G. Meigs, C. Meineri, A. Mele, V. Menkovski, S. Menmuir, A. Merle, H. Meyer, K. Mikszuta Michalik, D. Milanesio, F. Militello, A. Milocco, I.G. Miron, J. Mitchell, R. Mitteau, V. Mitterauer, J. Mlynar, V. Moiseenko, P. Molna, F. Mombelli, C. Monti, A. Montisci, J. Morales, P. Moreau, J.M. Moret, A. Moro, D. Moulton, P. Mulholland, M. Muraglia, A. Murari, A. Muraro, P. Muscente, D. Mykytchuk, F. Nabais, Y. Nakeva, F. Napoli, E. Nardon, M.F. Nave, R.D. Nem, A. Nielsen, S.K. Nielsen, M. Nocente, R. Nouailletas, S. Nowak, H. Nyström, R. Ochoukov, N. Offeddu, S. Olasz, C. Olde, F. Oliva, D. Oliveira, H.J.C. Oliver, P. Ollus, J. Ongena, F.P. Orsitto, N. Osborne, R. Otin, P. Oyola Dominguez, D.I. Palade, S. Palomba, O. Pan, N. Panadero, E. Panontin, A. Papadopoulos, P. Papagiannis, G. Papp, V.V. Parail, C. Pardanaud, J. Parisi, A. Parrott, K. Paschalidis, M. Passoni, F. Pastore, A. Patel, B. Patel, A. Pau, G. Pautasso, R. Pavlichenko, E. Pawelec, B. Pegourie, G. Pelka, E. Peluso, A. Perek, E. Perelli Cippo, C. Perez Von Thun, P. Petersson, G. Petravich, Y. Peysson, V. Piergotti, L. Pigatto, C. Piron, L. Piron, A. Pironti, F. Pisano, U. Plank, B. Ploeckl, V. Plyusnin, A. Podolnik, Y. Poels, G. Pokol, J. Poley, G. Por, M. Poradzinski, F. Porcelli, L. Porte, C. Possieri, A. Poulsen, I. Predebon, G. Pucella, M. Pueschel, P. Puglia, O. Putignano, T. Pütterich, V. Quadri, A. Quercia, M. Rabinski, L. Radovanovic, R. Ragona, H. Raj, M. Rasinski, J. Rasmussen, G. Ratta, S. Ratynskaia, R. Rayaprolu, M. Rebai, A. Redl, D. Rees, D. Refy, M. Reich, H. Reimerdes, B.C.G. Reman, O. Renders, C. Reux, D. Ricci, M. Richou, S. Rienacker, D. Rigamonti, F. Rigollet, F.G. Rimini, D. Ripamonti, N. Rispoli, N. Rivals, J.F. Rivero Rodriguez, C. Roach, G. Rocchi, S. Rode, P. Rodrigues, J. Romazanov, C.F. Romero Madrid, J. Rosato, R. Rossi, G. Rubino, J. Rueda Rueda, J. Ruiz Ruiz, P. Ryan, D. Ryan, S. Saarelma, R. Sabot, M. Salewski, A. Salmi, L. Sanchis, A. Sand, J. Santos, K. Särkimäki, M. Sassano, O. Sauter, G. Schettini, S. Schmuck, P. Schneider, N. Schoonheere, R. Schramm, R. Schrittwieser, C. Schuster, N. Schwarz, F. Sciortino, M. Scotto D’Abusco, S. Scully, A. Selce, L. Senni, M. Senstius, G. Sergienko, S.E. Sharapov, R. Sharma, A. Shaw, U. Sheikh, G. Sias, B. Sieglin, S.A. Silburn, C. Silva, A. Silva, D. Silvagni, B. Simmendefeldt Schmidt, L. Simons, J. Simpson, L. Singh, S. Sipilä, Y. Siusko, S. Smith, A. Snicker, E.R. Solano, V. Solokha, M. Sos, C. Sozzi, F. Spineanu, G. Spizzo, M. Spolaore, L. Spolladore, C. Srinivasan, A. Stagni, Z. Stancar, G. Stankunas, J. Stober, P. Strand, C.I. Stuart, F. Subba, G.Y. Sun, H.J. Sun, W. Suttrop, J. Svoboda, T. Szepesi, G. Szepesi, B. Tal, T. Tala, P. Tamain, G. Tardini, M. Tardocchi, D. Taylor, G. Telesca, A. Tenaglia, A. Terra, D. Terranova, D. Testa, C. Theiler, E. Tholerus, B. Thomas, E. Thoren, A. Thornton, A. Thrysoe, Q. TICHIT, W. Tierens, A. Titarenko, P. Tolias, E. Tomasina, M. Tomes, E. Tonello, A. Tookey, M. Toscano Jiménez, C. Tsironis, C. Tsui, A. Tykhyy, M. Ugoletti, M. Usoltseva, D.F. Valcarcel, A. Valentini, M. Valisa, M. Vallar, M. Valovic, SI. Valvis, M. van Berkel, D. Van Eester, S. Van Mulders, M. van Rossem, R. Vann, B. Vanovac, J. Varela Rodriguez, J. Varje, S. Vartanian, M. Vecsei, L. Velarde Gallardo, M. Veranda, T. Verdier, G. Verdoolaege, K. Verhaegh, L. Vermare, G. Verona Rinati, J. Vicente, E. Viezzer, L. Vignitchouk, F. Villone, B. Vincent, P. Vincenzi, M.O. Vlad, G. Vogel, I. Voitsekhovitch, I. Voldiner, P. Vondracek, N.M.T. VU, T. Vuoriheimo, C. Wade, E. Wang, T. Wauters, M. Weiland, H. Weisen, N. Wendler, D. Weston, A. Widdowson, S. Wiesen, M. Wiesenberger, T. Wijkamp, M. Willensdorfer, T. Wilson, A. Wojenski, C. Wuethrich, I. Wyss, L. Xiang, S. Xu, D. Yadykin, Y. Yakovenko, H. Yang, V. Yanovskiy, R. Yi, B. Zaar, G. Zadvitskiy, L. Zakharov, P. Zanca, D. Zarzoso, Y. Zayachuk, J. Zebrowski, M. Zerbini, P. Zestanakis, C. F. B. Zimmermann, M. Zlobinski, A. Zohar, V.K. Zotta, X. Zou, M. Zuin, M. Zurita, and I. Zychor

Subjects
JET, ASDEX Upgrade, MAST-U, TCV, WEST, Tokamak Exploitation Task Force, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Within the 9th European Framework programme, since 2021 EUROfusion is operating five tokamaks under the auspices of a single Task Force called ‘Tokamak Exploitation’. The goal is to benefit from the complementary capabilities of each machine in a coordinated way and help in developing a scientific output scalable to future largre machines. The programme of this Task Force ensures that ASDEX Upgrade, MAST-U, TCV, WEST and JET (since 2022) work together to achieve the objectives of Missions 1 and 2 of the EUROfusion Roadmap: i) demonstrate plasma scenarios that increase the success margin of ITER and satisfy the requirements of DEMO and, ii) demonstrate an integrated approach that can handle the large power leaving ITER and DEMO plasmas. The Tokamak Exploitation task force has therefore organized experiments on these two missions with the goal to strengthen the physics and operational basis for the ITER baseline scenario and for exploiting the recent plasma exhaust enhancements in all four devices (PEX: Plasma EXhaust) for exploring the solution for handling heat and particle exhaust in ITER and develop the conceptual solutions for DEMO. The ITER Baseline scenario has been developed in a similar way in ASDEX Upgrade, TCV and JET. Key risks for ITER such as disruptions and run-aways have been also investigated in TCV, ASDEX Upgrade and JET. Experiments have explored successfully different divertor configurations (standard, super-X, snowflakes) in MAST-U and TCV and studied tungsten melting in WEST and ASDEX Upgrade. The input from the smaller devices to JET has also been proven successful to set-up novel control schemes on disruption avoidance and detachment.

Published
2024
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10. A new 3MW ECRH system at 105 GHz for WEST

Author

Delpech, Lena, Alberti, Stefano, Avramidis, Konstantinos, Ayreault, Aline, Batal, Tristan, Bernard, Jean-Michel, Bouquey, Francis, Chelis, Ioannis, Clairet, Frederic, Corbel, Elodie, Doceul, Louis, Durand, Frederic, Dumont, Remi, Fonghetti, Theo, Gantenbein, Gerd, Garibaldi, Pascal, Giruzzi, Gerardo, Goodman, Tim, Hogge, Jean-Philippe, Illy, Stefan, Jelonnek, John, Jin, Jianbo, Laqua, Heinrich, Legrand, Francois, Lievin, Christophe, Magaud, Philippe, Maget, Patrick, Manas, Pierre, Marsen, Stefan, Regal-Mezin, Xavier, Mollard, Patrick, Mouyon, David, Nicolas, Laurent, Ouerfelli, Adam, Pagonakis, Ioannis, Robinet, Benjamin, Ruess, Tobias, Santraine, Benjamin, Thumm, Manfred, and Ioannidis, Zisis

Published
2023
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11. Transport barrier onset and edge turbulence shortfall in fusion plasmas

Author

Guilhem Dif-Pradalier, Philippe Ghendrih, Yanick Sarazin, Elisabetta Caschera, Frédéric Clairet, Yann Camenen, Peter Donnel, Xavier Garbet, Virginie Grandgirard, Yann Munschy, Laure Vermare, and Fabien Widmer

Subjects
Astrophysics, QB460-466, Physics, QC1-999
Abstract

A central problem in magnetized fusion plasmas is to understand whether the plasma edge sustains a turbulent state and transitions to improved confinement. The authors simulate the detailed organization of turbulence from the primitive flux-driven kinetic equations including plasma-solid interaction and identify basic mechanisms which allow to cure the oft-reported shortfall of turbulence power in the plasma edge and to describe spontaneous onset of a transport barrier.

Published
2022
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12. Collective fabrication of guided longitudinal SAW resonator without Bragg grating mirror

Author

Thomas Baron, Stefania Oliveri, Thomas Richard, Valerie Soumann, Djaffar Belharet, Laurent Robert, Marina Raschetti, Roland Salut, Emilie Courjon, Thierry Laroche, Florent Bernard, Alexandre Clairet, and Sylvain Ballandras

Subjects
5G mobile communication, acoustic devices, etching, microfabrication, nanofabrication, piezoelectric devices, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract

Abstract This Research article document discussed about a new structure composed of a sub‐micron‐thick layer of a single‐crystal piezoelectric material on a substrate. Longitudinal waves are used for experimental demonstration with 4’’ collective processes. Electrical experimental–computation validate the concept with Q × f products near 1012.

Published
2023
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14. Nucleosome patterns in four plant pathogenic fungi with contrasted genome structures

Author

Clairet, Colin, Lapalu, Nicolas, Simon, Adeline, Soyer, Jessica L., Viaud, Muriel, Zehraoui, Enric, Dalmais, Berengère, Fudal, Isabelle, and Ponts, Nadia

Subjects
Archaeology, CC1-960, Science
Abstract

Fungal pathogens represent a serious threat towards agriculture, health, and environment. Control of fungal diseases on crops necessitates a global understanding of fungal pathogenicity determinants and their expression during infection. Genomes of phytopathogenic fungi are often compartmentalized: the core genome contains housekeeping genes whereas the fast-evolving genome mainly contains transposable elements and species-specific genes. In this study, we analysed nucleosome landscapes of four phytopathogenic fungi with contrasted genome organizations to describe and compare nucleosome repartition patterns in relation with genome structure and gene expression level. We combined MNase-seq and RNA-seq analyses to concomitantly map nucleosome-rich and transcriptionally active regions during fungal growth in axenic culture; we developed the MNase-seq Tool Suite (MSTS) to analyse and visualise data obtained from MNase-seq experiments in combination with other genomic data and notably RNA-seq expression data. We observed different characteristics of nucleosome profiles between species, as well as between genomic regions within the same species. We further linked nucleosome repartition and gene expression. Our findings support that nucleosome positioning and occupancies are subjected to evolution, in relation with underlying genome sequence modifications. Understanding genomic organization and its role in expression regulation is the next gear to understand complex cellular mechanisms and their evolution.

Published
2023
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18. A Phase II Study Evaluating the Interest to Combine UCPVax, a Telomerase CD4 TH1-Inducer Cancer Vaccine, and Atezolizumab for the Treatment of HPV Positive Cancers: VolATIL Study

Author

Magali Rebucci-Peixoto, Angélique Vienot, Olivier Adotevi, Marion Jacquin, Francois Ghiringhelli, Christelle de la Fouchardière, Benoit You, Tristan Maurina, Elsa Kalbacher, Fernando Bazan, Guillaume Meynard, Anne-Laure Clairet, Christine Fagnoni-Legat, Laurie Spehner, Adeline Bouard, Dewi Vernerey, Aurélia Meurisse, Stefano Kim, Christophe Borg, and Laura Mansi

Subjects
HPV-related cancer, anal carcinoma, head and neck, cervix, atezolizumab, immunotherapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

BackgroundThere is a strong rational of using anti–programmed cell death protein-1 and its ligand (anti–PD-1/L1) antibodies in human papillomavirus (HPV)–induced cancers. However, anti–PD-1/L1 as monotherapy induces a limited number of objective responses. The development of novel combinations in order to improve the clinical efficacy of an anti–PD-1/L1 is therefore of interest. Combining anti–PD-1/L1 therapy with an antitumor vaccine seems promising in HPV-positive (+) cancers. UCPVax is a therapeutic cancer vaccine composed of two separate peptides derived from telomerase (hTERT, human telomerase reverse transcriptase). UCPVax is being evaluated in a multicenter phase I/II study in NSCLC (non–small cell lung cancer) and has demonstrated to be safe and immunogenic. The aim of the VolATIL study is to evaluate the combination of atezolizumab (an anti-PD-L1) and UCPVax vaccine in a multicenter phase II study in patients with HPV+ cancers.MethodsPatients with HPV+ cancer (anal canal, head and neck, and cervical or vulvar), at locally advanced or metastatic stage, and refractory to at least one line of systemic chemotherapy are eligible. The primary end point is the objective response rate (ORR) at 4 months. Patients will receive atezolizumab every 3 weeks at a fixed dose of 1,200 mg in combination with the UCPVax vaccine at 1 mg subcutaneously.DiscussionAnti-cancer vaccines can restore cancer-immunity via the expansion and activation of tumor-specific T cells in patients lacking pre-existing anti-tumor responses. Moreover, preclinical data showed that specific TH1 CD4 T cells sustain the quality and homing of an antigen-specific CD8+ T-cell immunity. In previous clinical studies, the induction of anti-hTERT immunity was significantly correlated to survival in patients with advanced squamous anal cell carcinoma. Thus, there is a strong rational to combine an anti-cancer hTERT vaccine and an immune checkpoint inhibitor to activate and promote antitumor T-cell immunity. This pivotal proof of concept study will evaluate the efficacy and safety of the combination of a telomerase-based TH1 inducing vaccine (UCPVax) and an anti–PD-L1 (atezolizumab) immunotherapy in HPV+ cancers, as well as confirming their synergic mechanism, and settling the basis for a new combination for future clinical trials.Clinical Trial Registrationhttps://www.clinicaltrials.gov/, identifier NCT03946358.

Published
2022
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21. Separatrix parameters and core performances across the WEST L-mode database

Author

C. Bourdelle, J. Morales, J.F. Artaud, O. Grover, T. Radenac, J. Bucalossi, Y. Camenen, G. Ciraolo, F. Clairet, R. Dumont, N. Fedorczak, J. Gaspar, C. Gil, M. Goniche, C. Guillemaut, J. Gunn, P. Maget, P. Manas, V. Ostuni, B. Pégourié, Y. Peysson, P. Tamain, L. Vermare, D. Vézinet, and the WEST Team

Subjects
plasma, tokamak, database, confinement, separatrix, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

WEST database analysis shows a correlation of the recycled neutral source around the separatrix with core performances. This observation questions the causality chain between particle source and turbulent transport up to the core in L-mode, high recycling plasmas, an unavoidable phase of all scenarios. The best core performances correlate with the lowest values of the density at the separatrix, ${n_{{\text{sep}}}}$ , similarly to ASDEX Upgrade (AUG) tokamak and Joint European Torus (JET) tokamak in H-mode (Verdoolaege et al 2021 Nucl. Fusion 61 076006). Reflectometry in the midplane provides ${n_{{\text{sep}}}}$ , while the temperature at the separatrix, ${T_{{\text{sep}}}}$ is inferred by the ‘two-point model’ using Langmuir probe data on divertor targets. Lower separatrix resistivity does not correlate with better core performances, unlike H-mode observations (Eich et al 2020 Nucl. Fusion 60 056016). As expected in the presence of an efficient neutral source due to recycling fluxes, ${n_{{\text{sep}}}}$ correlates with the D recycled particle flux at the divertor measured by visible spectroscopy. Coherently, at a given controlled central line integrated density $\bar n$ , lower ${n_{{\text{sep}}}}$ correlates with a larger density gradient around the separatrix as well as a larger global density peaking, $\bar n/\langle n\rangle $ , measured by interferometry. The latter correlates as well with lower collisionality in the core, similarly to JET and AUG H-modes (Angioni et al 2007 Nucl. Fusion 47 1326). The correlations reported allow phrasing the subsequent causality question: what is the interplay chain between low neutral recycling at the divertor plates, low density at the separatrix, high density peaking at the separatrix, high global density peaking, higher central temperature and better core energy confinement quality? Understanding the causality chain is essential to prepare ITER operation and design DEMO scenarios where the ratio of the divertor leg to the ionization length will be larger and where the pumped flux with respect to the plasma volume will be lower than presently operating tokamaks.

Published
2023
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22. Regulation of effector gene expression as concerted waves in Leptosphaeria maculans: a two‐player game.

Author

Clairet, Colin, Gay, Elise J., Porquier, Antoine, Blaise, Françoise, Marais, Claire‐Line, Balesdent, Marie‐Hélène, Rouxel, Thierry, Soyer, Jessica L., and Fudal, Isabelle

Subjects
*GENETIC regulation, *LEPTOSPHAERIA maculans, *RAPESEED, *GENE expression, *TRANSCRIPTION factors
Abstract

Summary: Effector genes, encoding molecules involved in disease establishment, are concertedly expressed throughout the lifecycle of plant‐pathogenic fungi. However, little is known about how effector gene expression is regulated. Since many effector genes are located in repeat‐rich regions, the role of chromatin remodeling in their regulation was recently investigated, notably establishing that the repressive histone modification H3K9me3, deposited by KMT1, was involved in several fungal species including Leptosphaeria maculans. Nevertheless, previous data suggest that a second regulatory layer, probably involving a specific transcription factor (TF), might be required.In L. maculans, a Dothideomycete causing stem canker of oilseed rape, we identified the ortholog of Pf2, a TF belonging to the Zn2Cys6 fungal‐specific family, and described as essential for pathogenicity and effector gene expression. We investigated its role together with KMT1, by inactivating and over‐expressing LmPf2 in a wild‐type strain and a ∆kmt1 mutant.Functional analyses of the corresponding transformants highlighted an essential role of LmPf2 in the establishment of pathogenesis and we found a major effect of LmPf2 on the induction of effector gene expression once KMT1 repression is lifted.Our results show, for the first time, a dual control of effector gene expression. [ABSTRACT FROM AUTHOR]

Published
2024
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23. ATMP Environmental Exposure Assessment in European Healthcare Settings: A Systematic Review of the Literature

Author

Margaux Damerval, Christine Fagnoni-Legat, Aurélien Louvrier, Sarah Fischer, Samuel Limat, Anne-Laure Clairet, Virginie Nerich, Isabelle Madelaine, and Marie Kroemer

Subjects
advanced therapy medicinal products (ATMP), cell and gene therapy (CGT), environmental exposure, environmental shedding, cellular therapy, healthcare settings, Medicine (General), R5-920
Abstract

Since 2007, a new class of biologic products for human use called “advanced therapy medicinal products (ATMP)” have been legally integrated in the European Medical Agency. They consist of recombinant nucleic acid, engineered cells, cells, or tissues. In the United States, ATMP fall under the regulatory framework of biological products and the term “cell and gene therapy product” is used in the legislative and regulatory documents. Potential clinical applications are broad, particularly, in the field of cancer, inherited genetic disease, and regenerative medicine. Indeed, the benefit conferred by CD19 chimeric antigen receptor T cells led to the first engineered cell therapy products to be approved by the Food and Drug Administration (FDA) in 2017. Gene therapy products to treat orphan diseases are also extensively developed with many clinical trials ongoing in the world. Nevertheless, the use of these therapeutic products is complex and requires careful considerations in the terms of regulatory and hospital setting requirements, such as storage, handling, administration, and disposal which justify the implementation of a secured medication circuit. Through this systematic review of the literature, the authors wanted to compile data on the assessment of environmental exposure related to the use of ATMP in healthcare setting to secure their medication circuit. A literature search was conducted on PubMed and Web of Science, and 32 publications dealing with environmental exposure assessment and ATMP were selected. In addition, marketed ATMPs were identified and data regarding the environmental concerns were extracted from product information sections from European Public Assessment Reports (EPAR). The environmental contamination assessments were mainly addressed in the reviews rather than in original articles related to the use of ATMP. Most of the product information sections from EPAR suggested precautions rather than requirements when dealing with environmental consideration following ATMP handling. Nevertheless, these precautions usually remain elusive especially concerning waste disposal and the detection of biological material on the work surfaces, and mainly relate to the genetically modified organisms (GMO) over non-GMO cellular products. Pharmaceutical oversight and adherence to the good preparation practices and good clinical practices are essential to ensure the safe use in term of environmental concern of these new therapeutic products in healthcare setting.

Published
2021
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25. Differential acclimation kinetics of the two forms of type IV chromatic acclimaters occurring in marine Synechococcus cyanobacteria.

Author

Dufour, Louison, Garczarek, Laurence, Gouriou, Bastian, Clairet, Julia, Ratin, Morgane, and Partensky, Frédéric

Subjects
SYNECHOCOCCUS, ACCLIMATIZATION, CYANOBACTERIA, PHYCOBILISOMES, MARINE organisms
Abstract

Synechococcus, the second most abundant marine phytoplanktonic organism, displays the widest variety of pigment content of all marine oxyphototrophs, explaining its ability to colonize all spectral niches occurring in the upper lit layer of oceans. Seven Synechococcus pigment types (PTs) have been described so far based on the phycobiliprotein composition and chromophorylation of their light-harvesting complexes, called phycobilisomes. The most elaborate and abundant PT (3d) in the open ocean consists of cells capable of type IV chromatic acclimation (CA4), i.e., to reversibly modify the ratio of the blue light-absorbing phycourobilin (PUB) to the green light-absorbing phycoerythrobilin (PEB) in phycobilisome rods to match the ambient light color. Two genetically distinct types of chromatic acclimaters, so-called PTs 3dA and 3dB, occur at similar global abundance in the ocean, but the precise physiological differences between these two types and the reasons for their complementary niche partitioning in the field remain obscure. Here, photoacclimation experiments in different mixes of blue and green light of representatives of these two PTs demonstrated that they differ by the ratio of blue-to-green light required to trigger the CA4 process. Furthermore, shift experiments between 100% blue and 100% green light, and vice-versa, revealed significant discrepancies between the acclimation pace of the two types of chromatic acclimaters. This study provides novel insights into the finely tuned adaptation mechanisms used by Synechococcus cells to colonize the whole underwater light field. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Terminal Care in Parkinson's Disease: Real-Life Use of Continuous Subcutaneous Apomorphine Infusion to Improve Patient Comfort.

Author

Béreau, Matthieu, Giffard, Mathilde, Clairet, Anne-Laure, Degenne, Guillaume, Tatu, Laurent, Richfield, Edward, Magnin, Eloi, Vérin, Marc, and Auffret, Manon

Subjects
TERMINAL care, PARKINSON'S disease, SUBCUTANEOUS infusions, ADVANCE directives (Medical care), CUTANEOUS manifestations of general diseases
Abstract

Background: There are currently no recommendations on the therapeutic management of Parkinson's disease (PD) patients at the end of life. Objective: To describe a cohort of patients with PD who benefited from continuous subcutaneous apomorphine infusion (CSAI) initiation at the end of their life as comfort care. Methods: This real-life cohort includes 14 PD patients, who benefited from 24-h, low-dose CSAI (0.5–3 mg/h) in the context of terminal care. Patient's comfort (pain, rigidity, and/or ability to communicate) and occurrence of CSAI-related side-effects (nausea/vomiting, cutaneous and behavioral manifestations) were evaluated based on medical records. Results: All patients (age 62–94 years, disease duration 2–32 years) presented with late-stage PD and a compromised oral route. Treatment lasted from a few hours to 39 days. CSAI led to substantial functional improvement, with a good safety profile. Overall clinical comfort was deemed improved by the medical team, the patient, and/or caregivers. Conclusions: CSAI might be a promising approach in PD terminal care, as it reduces motor symptoms and overall discomfort, with an apparent good safety profile. Use of the apomorphine pen, sublingual film or a classic syringe pump might be considered when apomorphine pumps are not available. Larger observational cohorts and randomized controlled trials are needed to establish the efficacy and tolerability of apomorphine in the context of terminal care and more broadly, in an advance care planning perspective. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Heat flux analysis of Type-I ELM impact on a sloped, protruding surface in the JET bulk tungsten divertor

Author

J. Gaspar, J.W. Coenen, Y. Corre, R. Dejarnac, M. Firdaouss, F. Clairet, J. Gunn, D. Iglesias, M. Komm, K. Krieger, G. Matthews, R.A. Pitts, and S. Silburn

Subjects
Nuclear engineering. Atomic power, TK9001-9401
Abstract

Tungsten (W) melting due to transient power loads, for example those delivered by edge localised modes (ELMs), is a major concern for next step fusion devices. A series of experiments has been performed on JET to investigate the dynamics of Type-I ELM-induced transient melting. Following initial exposures in 2013 of a W-lamella with sharp leading edge in the bulk W outer divertor, new experiments have been performed in 2016–2017 on a protruding W-lamella with a 15° slope, allowing direct and spatially resolved (0.85 mm/pixel) observation of the top surface using the IR thermography system viewing from the top of the poloidal cross-section. Thermal and IR analysis have already been conducted assuming the geometrical projection of the parallel heat flux on the W-lamellas, thus ignoring the gyro-radius orbit of plasma particles. Although it is well justified during L-mode or inter-ELM period, the hypothesis becomes questionable during ELM when the ion Larmor radius is larger. The goal of this paper is to extend the previous analysis based on the forward approach to the H-mode discharges and investigate in particular the gyro-radius effect during the Type-I ELMs, those used to achieve transient melting on the slope of the protruding W-lamella. Surface temperatures measured by the IR camera are compared with reconstructed synthetic data from 3D thermal modelling using heat loads derived from optical projection of the parallel heat flux (ignoring the gyro-radius orbit), 2D gyro-radius orbit and particle-in-cell (PIC) simulations describing the influence of finite Larmor-radius effects and electrical potential on the deposited power flux. Results show that the ELM power deposition behaves differently than the optical projection of the parallel heat flux, contrary to the L-mode observations, and may thus be due to the much larger gyro-orbits of the energetic ELM ions in comparison to L-mode or inter-ELM conditions. Keywords: ELM heat flux analysis, Optical projection, PIC modelling, Ion orbit modelling, IR data, Spatial resolution effect

Published
2018
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30. Measurements and controls implementation for WEST

Author

Moreau, P., Bucalossi, J., Missirlian, M., Samaille, F., Courtois, X., Gil, C., Lotte, P., Meyer, O., Nardon, E., Nouailletas, R., Ravenel, N., Travere, J.M., Alarcon, T., Antusch, S., Aumeunier, M.H., Barjat, P., Belsare, S., Bernard, J.M., Bhandarkar, M., Bottereau, C., Bourdelle, C., Brémond, S., Camenen, Y., Chaudhari, V., Chavda, C., Chernyshova, M., Clairet, F., Colnel, J., Czarski, T., Choi, M., Colledani, G., Corre, Y., Daniel, R., Davis, D., Dejarnac, R., Devynck, P., Dhongde, J., Douai, D., Elbeze, D., Escarguel, A., Fenzi, C., Figacz, W., Guangwu, Z., Giacalone, J.C., Guirlet, R., Gunn, J., Hacquin, S., Hao, X., Harris, J.H., Hoang, G.T., Houry, M., Imbeaux, F., Jablonski, S., Jardin, A., Joshi, H., Kasprowicz, G., Klepper, C.C., Kowalska-Strzeciwilk, E., Kubkowska, M., Kumar, A., Kumar, V., Kumari, P., Laqua, H., Le-Luyer, A., Lee, W., Lewerentz, M., Lyu, B., Malard, P., Manenc, L., Mansuri, I., Marandet, Y., Masand, H., Mazon, D., Molina, D., Moureau, G., Nam, Y., Park, H., Pascal, J.Y., Patel, K., Patel, M., Pozniak, K., Radloff, D., Ranjan, S., Rapson, C., Raupp, G., Rieth, M., Sabot, R., Santraine, B., Sestac, D., Sharma, M., Shen, J., Signoret, J., Soni, J., Spring, A., Spuig, P., Sugandhi, R., Treuterrer, W., Tsitrone, E., Varshney, S., Vartanian, S., Volpe, D., Wang, F.D., Werner, A., Yun, G., Zabolotny, W., and Zhao, W.

Published
2017
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32. COMPARATIVE ANALYSIS OF LATE RESULTS OF CERVICAL ESOPHAGOGASTRIC ANASTOMOSIS BY MANUAL AND MECHANICAL SUTURE IN PATIENTS SUBMITTED TO ESOPHAGEAL MUCOSECTOMY THROUGH ADVANCED MEGAESOPHAGUS

Author

José Luis Braga de AQUINO, Vania Aparecida LEANDRO-MERHI, José Alexandre MENDONÇA, Elisa Donalisio Teixeira MENDES, Conceição de Maria Aquino Vieira CLAIRET, and Leonardo Oliveira REIS

Subjects
Esophageal achalasia, Anastomosis, surgical, Suture techniques, Surgery, RD1-811, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

ABSTRACT Background: Among the anastomoses of the gastrointestinal tract, those of the esophagus are of special interest due to several anatomical or even general peculiarities. Aim: Evaluate retrospectively the results comparing mechanical vs. manual suture at cervical esophagogastric anastomosis in megaesophagus treatment. Methods: Were included 92 patients diagnosed with advanced megaesophagus with clinical conditions to undergo the surgery. All underwent esophageal mucosectomy, performing anastomosis of the esophagus stump with the gastric tube at the cervical level. In order to make this anastomosis, the patients were divided into two groups: group A (n=53) with circular mechanical suture, lateral end; group B (n=39) with manual suture in two sides, lateral end. In the postoperative period, an early evaluation was performed, analyzing local and systemic complications and late (average 5.6 y) analyzing deglutition. Results: Early evaluation: a) dehiscence of esophagogastric anastomosis n=5 (9.4%) in group A vs. n=9 (23.0%) in group B (p=0.0418); b) stenosis of esophagogastric anastomosis n=8 (15.1%) in group A vs. n=15 (38.4%) in group B (p=0.0105.); c) pulmonary infection n=5 (9.4%) in group A vs. n=3 (7.6%) in group B (p=1.0000.); d) pleural effusion n=5 (9.4%) in group A vs. n=6 (15.4%) in group B (p

Published
2019
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34. An Astyanax mexicanus mao knockout line uncovers the developmental roles of monoamine homeostasis in fish brain.

Author

Alunni, Alessandro, Pierre, Constance, Torres‐Paz, Jorge, Clairet, Natacha, Langlumé, Auriane, Pavie, Marie, Escoffier‐Pirouelle, Thomas, Leblanc, Michael, Blin, Maryline, and Rétaux, Sylvie

Subjects
RAPHE nuclei, MONOAMINE transporters, HYPOTHALAMUS, ASTYANAX, MONOAMINE oxidase, HOMEOSTASIS, DOPAMINERGIC neurons, BRAIN physiology
Abstract

Monoaminergic systems are conserved in vertebrates, yet they present variations in neuroanatomy, genetic components and functions across species. MonoAmine Oxidase, or MAO, is the enzyme responsible for monoamine degradation. While mammals possess two genes, MAO‐A and MAO‐B, fish possess one single mao gene. To study the function of MAO and monoamine homeostasis on fish brain development and physiology, here we have generated a mao knockout line in Astyanax mexicanus (surface fish), by CRISPR/Cas9 technology. Homozygote mao knockout larvae died at 13 days post‐fertilization. Through a time‐course analysis, we report that hypothalamic serotonergic neurons undergo fine and dynamic regulation of serotonin level upon loss of mao function, in contrast to those in the raphe, which showed continuously increased serotonin levels – as expected. Dopaminergic neurons were not affected by mao loss‐of‐function. At behavioral level, knockout fry showed a transient decrease in locomotion that followed the variations in the hypothalamus serotonin neuronal levels. Finally, we discovered a drastic effect of mao knockout on brain progenitors proliferation in the telencephalon and hypothalamus, including a reduction in the number of proliferative cells and an increase of the cell cycle length. Altogether, our results show that MAO has multiple and varied effects on Astyanax mexicanus brain development. Mostly, they bring novel support to the idea that serotonergic neurons in the hypothalamus and raphe of the fish brain are different in nature and identity, and they unravel a link between monoaminergic homeostasis and brain growth. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Separatrix parameters and core performances across WEST L-mode database

Author

C. Bourdelle, J. Morales, J.F. Artaud, O. Grover, T. Radenac, J. Bucalossi, Y. Camenen, G. Ciraolo, F. Clairet, R. Dumont, N. Fedorczak, J. Gaspar, C. Gil, M. Goniche, C. Guillemaut, J. Gunn, P. Maget, P. Manas, V. Ostuni, B. Pégourié, Y. Peysson, P. Tamain, L. Vermare, D. Vézinet, Institut de Recherche sur la Fusion par confinement Magnétique (IRFM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Max-Planck-Institut, Physique des interactions ioniques et moléculaires (PIIM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU), European Project: 101052200,Implementation of activities described in the Roadmap to Fusion during Horizon Europe through a joint programme of the members of the EUROfusion consortium,EUROfusion, European Project: 633053,H2020,EURATOM-Adhoc-2014-20,EUROfusion(2014), and WEST Team

Subjects
[PHYS]Physics [physics], Nuclear and High Energy Physics, [PHYS.PHYS.PHYS-PLASM-PH]Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph], Condensed Matter Physics
Abstract

WEST database analysis shows a correlation of the recycled neutral source around the separatrix with core performances. This observation questions the causality chain between particle source and turbulent transport up to the core in L-mode, high recycling plasmas, an unavoidable phase of all scenarios. The best core performances correlate with the lowest values of the density at the separatrix, n sep , similarly to ASDEX Upgrade (AUG) tokamak and Joint European Torus (JET) tokamak in H-mode (Verdoolaege et al 2021 Nucl. Fusion 61 076006). Reflectometry in the midplane provides n sep , while the temperature at the separatrix, T sep is inferred by the ‘two-point model’ using Langmuir probe data on divertor targets. Lower separatrix resistivity does not correlate with better core performances, unlike H-mode observations (Eich et al 2020 Nucl. Fusion 60 056016). As expected in the presence of an efficient neutral source due to recycling fluxes, n sep correlates with the D recycled particle flux at the divertor measured by visible spectroscopy. Coherently, at a given controlled central line integrated density n ˉ , lower n sep correlates with a larger density gradient around the separatrix as well as a larger global density peaking, n ˉ / ⟨ n ⟩ , measured by interferometry. The latter correlates as well with lower collisionality in the core, similarly to JET and AUG H-modes (Angioni et al 2007 Nucl. Fusion 47 1326). The correlations reported allow phrasing the subsequent causality question: what is the interplay chain between low neutral recycling at the divertor plates, low density at the separatrix, high density peaking at the separatrix, high global density peaking, higher central temperature and better core energy confinement quality? Understanding the causality chain is essential to prepare ITER operation and design DEMO scenarios where the ratio of the divertor leg to the ionization length will be larger and where the pumped flux with respect to the plasma volume will be lower than presently operating tokamaks.

Published
2023

40. Separatrix parameters and core performances across WEST L-mode database

Author

Bourdelle, Clarisse, Morales, Jorge, Artaud, Jean François, Radenac, T., Bucalossi, Jérôme, Clairet, Frédéric, Ciraolo, Guido, Dumont, Rémi, Fedorczak, Nicolas, Gil, Christophe, Goniche, Marc, Guillemaut, Christophe, Gunn, James-Paul, Maget, Patrick, Manas, Pierre, Ostuni, Valeria, Pégourié, Bernard, Peysson, Yves, Tamain, Patrick, Vermare, L., Vezinet, Didier, Camenen, Yann, Grover, Ondrej, CEA Cadarache, Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut de Recherche sur la Fusion par confinement Magnétique (IRFM), and The WEST Team

Subjects
[PHYS.PHYS.PHYS-PLASM-PH]Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph]
Abstract

International audience

Published
2022

41. Physics of E x B staircases

Author

Dif-Pradalier, G., Clairet, F., Diamond, P., Donnel, P., Garbet, X., Ghendrih, V., Grandgirard, A., Medvedeva, A., Milovanov, A., Sarazin, Y., Vermare, L., Institut de Recherche sur la Fusion par confinement Magnétique (IRFM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), University of California [San Diego] (UC San Diego), University of California (UC), UCSD-CNRS Joint Research Chemistry Laboratory (UMI 3555), University of California (UC)-University of California (UC)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), CEA Cadarache, Laboratoire de Mécanique, Modélisation et Procédés Propres (M2P2), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Italian National agency for new technologies, Energy and sustainable economic development [Frascati] (ENEA), Laboratoire de Physique des Plasmas (LPP), Observatoire de Paris, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École polytechnique (X)-Sorbonne Université (SU)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS]Physics [physics], [PHYS.PHYS.PHYS-PLASM-PH]Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph]
Abstract

International audience

Published
2022

43. Global scaling of the heat transport in fusion plasmas

Author

Sara Moradi, Johan Anderson, Michele Romanelli, Hyun-Tae Kim, JET contributors, X. Litaudon, S. Abduallev, M. Abhangi, P. Abreu, M. Afzal, K. M. Aggarwal, T. Ahlgren, J. H. Ahn, L. Aho-Mantila, N. Aiba, M. Airila, R. Albanese, V. Aldred, D. Alegre, E. Alessi, P. Aleynikov, A. Alfier, A. Alkseev, M. Allinson, B. Alper, E. Alves, G. Ambrosino, R. Ambrosino, L. Amicucci, V. Amosov, E. Andersson Sundén, M. Angelone, M. Anghel, C. Angioni, L. Appel, C. Appelbee, P. Arena, M. Ariola, H. Arnichand, S. Arshad, A. Ash, N. Ashikawa, V. Aslanyan, O. Asunta, F. Auriemma, Y. Austin, L. Avotina, M. D. Axton, C. Ayres, M. Bacharis, A. Baciero, D. Baião, S. Bailey, A. Baker, I. Balboa, M. Balden, N. Balshaw, R. Bament, J. W. Banks, Y. F. Baranov, M. A. Barnard, D. Barnes, M. Barnes, R. Barnsley, A. Baron Wiechec, L. Barrera Orte, M. Baruzzo, V. Basiuk, M. Bassan, R. Bastow, A. Batista, P. Batistoni, R. Baughan, B. Bauvir, L. Baylor, B. Bazylev, J. Beal, P. S. Beaumont, M. Beckers, B. Beckett, A. Becoulet, N. Bekris, M. Beldishevski, K. Bell, F. Belli, M. Bellinger, É. Belonohy, N. Ben Ayed, N. A. Benterman, H. Bergsȧker, J. Bernardo, M. Bernert, M. Berry, L. Bertalot, C. Besliu, M. Beurskens, B. Bieg, J. Bielecki, T. Biewer, M. Bigi, P. Bìlkovà, F. Binda, A. Bisoffi, J. P. S. Bizarro, C. Björkas, J. Blackburn, K. Blackman, T. R. Blackman, P. Blanchard, P. Blatchford, V. Bobkov, A. Boboc, G. Bodnàr, O. Bogar, I. Bolshakova, T. Bolzonella, N. Bonanomi, F. Bonelli, J. Boom, J. Booth, D. Borba, D. Borodin, I. Borodkina, A. Botrugno, C. Bottereau, P. Boulting, C. Bourdelle, M. Bowden, C. Bower, C. Bowman, T. Boyce, C. Boyd, H. J. Boyer, J. M. A. Bradshaw, V. Braic, R. Bravanec, B. Breizman, S. Bremond, P. D. Brennan, S. Breton, A. Brett, S. Brezinsek, M. D. J. Bright, M. Brix, W. Broeckx, M. Brombin, A. Brosawski, D. P. D. Brown, M. Brown, E. Bruno, J. Bucalossi, J. Buch, J. Buchanan, M. A. Buckley, R. Budny, H. Bufferand, M. Bulman, N. Bulmer, P. Bunting, P. Buratti, A. Burckhart, A. Buscarino, A. Busse, N. K. Butler, I. Bykov, J. Byrne, P. Cahyna, G. Calabrò, I. Calvo, Y. Camenen, P. Camp, D. C. Campling, J. Cane, B. Cannas, A. J. Capel, P. J. Card, A. Cardinali, P. Carman, M. Carr, D. Carralero, L. Carraro, B. B. Carvalho, I. Carvalho, P. Carvalho, F. J. Casson, C. Castaldo, N. Catarino, J. Caumont, F. Causa, R. Cavazzana, K. Cave-Ayland, M. Cavinato, M. Cecconello, S. Ceccuzzi, E. Cecil, A. Cenedese, R. Cesario, C. D. Challis, M. Chandler, D. Chandra, C. S. Chang, A. Chankin, I. T. Chapman, S. C. Chapman, M. Chernyshova, G. Chitarin, G. Ciraolo, D. Ciric, J. Citrin, F. Clairet, E. Clark, M. Clark, R. Clarkson, D. Clatworthy, C. Clements, M. Cleverly, J. P. Coad, P. A. Coates, A. Cobalt, V. Coccorese, V. Cocilovo, S. Coda, R. Coelho, J. W. Coenen, I. Coffey, L. Colas, S. Collins, D. Conka, S. Conroy, N. Conway, D. Coombs, D. Cooper, S. R. Cooper, C. Corradino, Y. Corre, G. Corrigan, S. Cortes, D. Coster, A. S. Couchman, M. P. Cox, T. Craciunescu, S. Cramp, R. Craven, F. Crisanti, G. Croci, D. Croft, K. Crombé, R. Crowe, N. Cruz, G. Cseh, A. Cufar, A. Cullen, M. Curuia, A. Czarnecka, H. Dabirikhah, P. Dalgliesh, S. Dalley, J. Dankowski, D. Darrow, O. Davies, W. Davis, C. Day, I. E. Day, M. De Bock, A. de Castro, E. de la Cal, E. de la Luna, G. De Masi, J. L. de Pablos, G. De Temmerman, G. De Tommasi, P. de Vries, K. Deakin, J. Deane, F. Degli Agostini, R. Dejarnac, E. Delabie, N. den Harder, R. O. Dendy, J. Denis, P. Denner, S. Devaux, P. Devynck, F. Di Maio, A. Di Siena, C. Di Troia, P. Dinca, R. Dinca, B. Ding, T. Dittmar, H. Doerk, R. P. Doerner, T. Donné, S. E. Dorling, S. Dormido-Canto, S. Doswon, D. Douai, P. T. Doyle, A. Drenik, P. Drewelow, P. Drews, Ph. Duckworth, R. Dumont, P. Dumortier, D. Dunai, M. Dunne, I. Duran, F. Durodié, P. Dutta, B. P. Duval, R. Dux, K. Dylst, N. Dzysiuk, P. V. Edappala, J. Edmond, A. M. Edwards, J. Edwards, Th. Eich, A. Ekedahl, R. El-Jorf, C. G. Elsmore, M. Enachescu, G. Ericsson, F. Eriksson, J. Eriksson, L. G. Eriksson, B. Esposito, S. Esquembri, H. G. Esser, D. Esteve, B. Evans, G. E. Evans, G. Evison, G. D. Ewart, D. Fagan, M. Faitsch, D. Falie, A. Fanni, A. Fasoli, J. M. Faustin, N. Fawlk, L. Fazendeiro, N. Fedorczak, R. C. Felton, K. Fenton, A. Fernades, H. Fernandes, J. Ferreira, J. A. Fessey, O. Février, O. Ficker, A. Field, S. Fietz, A. Figueiredo, J. Figueiredo, A. Fil, P. Finburg, M. Firdaouss, U. Fischer, L. Fittill, M. Fitzgerald, D. Flammini, J. Flanagan, C. Fleming, K. Flinders, N. Fonnesu, J. M. Fontdecaba, A. Formisano, L. Forsythe, L. Fortuna, E. Fortuna-Zalesna, M. Fortune, S. Foster, T. Franke, T. Franklin, M. Frasca, L. Frassinetti, M. Freisinger, R. Fresa, D. Frigione, V. Fuchs, D. Fuller, S. Futatani, J. Fyvie, K. Gàl, D. Galassi, K. Galazka, J. Galdon-Quiroga, J. Gallagher, D. Gallart, R. Galvão, X. Gao, Y. Gao, J. Garcia, A. Garcia-Carrasco, M. Garca-Munoz, J.-L. Gardarein, L. Garzotti, P. Gaudio, E. Gauthier, D. F. Gear, S. 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Wischmeier, G. Withenshaw, A. Withycombe, D. M. Witts, D. Wood, R. Wood, C. Woodley, S. Wray, J. Wright, J. C. Wright, J. Wu, S. Wukitch, A. Wynn, T. Xu, D. Yadikin, W. Yanling, L. Yao, V. Yavorskij, M. G. Yoo, C. Young, D. Young, I. D. Young, R. Young, J. Zacks, R. Zagorski, F. S. Zaitsev, R. Zanino, A. Zarins, K. D. Zastrow, M. Zerbini, W. Zhang, Y. Zhou, E. Zilli, V. Zoita, S. Zoletnik, and I. Zychor

Subjects
Physics, QC1-999
Abstract

A global heat flux model based on a fractional derivative of plasma pressure is proposed for the heat transport in fusion plasmas. The degree of the fractional derivative of the heat flux, α, is defined through the power balance analysis of the steady state. The model was used to obtain the experimental values of α for a large database of the Joint European Torus (JET) carbon-wall as well as ITER like-wall plasmas. The fractional degrees of the electron heat flux are found to be α

Published
2020
Full Text
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44. Progress from ASDEX Upgrade experiments in preparing the physics basis of ITER operation and DEMO scenario development

Author

U. Stroth, D. Aguiam, E. Alessi, C. Angioni, N. Arden, R. Arredondo Parra, V. Artigues, O. Asunta, M. Balden, V. Bandaru, A. Banon-Navarro, K. Behler, A. Bergmann, M. Bergmann, J. Bernardo, M. Bernert, A. Biancalani, R. Bielajew, R. Bilato, G. Birkenmeier, T. Blanken, V. Bobkov, A. Bock, T. Body, T. Bolzonella, N. Bonanomi, A. Bortolon, B. Böswirth, C. Bottereau, A. Bottino, H. van den Brand, M. Brenzke, S. Brezinsek, D. Brida, F. Brochard, C. Bruhn, J. Buchanan, A. Buhler, A. Burckhart, Y. Camenen, B. Cannas, P. Cano Megias, D. Carlton, M. Carr, P. Carvalho, C. Castaldo, M. Cavedon, C. Cazzaniga, C. Challis, A. Chankin, C. Cianfarani, F. Clairet, S. Coda, R. Coelho, J.W. Coenen, L. Colas, G. Conway, S. Costea, D. Coster, T. Cote, A.J. Creely, G. Croci, D.J. Cruz Zabala, G. Cseh, A. Czarnecka, I. Cziegler, O. D’Arcangelo, A. Dal Molin, P. David, C. Day, M. de Baar, P. de Marné, R. Delogu, S. Denk, P. Denner, A. Di Siena, J.J. Dominguez Palacios Durán, D. Dunai, A. Drenik, M. Dreval, R. Drube, M. Dunne, B.P. Duval, R. Dux, T. Eich, S. Elgeti, A. Encheva, K. Engelhardt, B. Erdös, I. Erofeev, B. Esposito, E. Fable, M. Faitsch, U. Fantz, M. Farnik, H. Faugel, F. Felici, O. Ficker, S. Fietz, A. Figueredo, R. Fischer, O. Ford, L. Frassinetti, M. Fröschle, G. Fuchert, J.C. Fuchs, H. Fünfgelder, S. Futatani, K. Galazka, J. Galdon-Quiroga, D. Gallart Escolà, A. Gallo, Y. Gao, S. Garavaglia, M. Garcia Muñoz, B. Geiger, L. Giannone, S. Gibson, L. Gil, E. Giovannozzi, S. Glöggler, M. Gobbin, J. Gonzalez Martin, T. Goodman, G. Gorini, T. Görler, D. Gradic, G. Granucci, A. Gräter, H. Greuner, M. Griener, M. Groth, A. Gude, L. Guimarais, S. Günter, G. Haas, A.H. Hakola, C. Ham, T. Happel, N. den Harder, G. Harrer, J. Harrison, V. Hauer, T. Hayward-Schneider, B. Heinemann, T. Hellsten, S. Henderson, P. Hennequin, A. Herrmann, E. Heyn, F. Hitzler, J. Hobirk, K. Höfler, J.H. Holm, M. Hölzl, C. Hopf, L. Horvath, T. Höschen, A. Houben, A. Hubbard, A. Huber, K. Hunger, V. Igochine, M. Iliasova, T. Ilkei, K. Insulander Björk, C. Ionita-Schrittwieser, I. Ivanova-Stanik, W. Jacob, N. Jaksic, F. Janky, A. Jansen van Vuuren, A. Jardin, F. Jaulmes, F. Jenko, T. Jensen, E. Joffrin, A. Kallenbach, S. Kálvin, M. Kantor, A. Kappatou, O. Kardaun, J. Karhunen, C.-P. Käsemann, S. Kasilov, A. Kendl, W. Kernbichler, E. Khilkevitch, A. Kirk, S. Kjer Hansen, V. Klevarova, G. Kocsis, M. Koleva, M. Komm, M. Kong, A. Krämer-Flecken, K. Krieger, A. Krivska, O. Kudlacek, T. Kurki-Suonio, B. Kurzan, B. Labit, K. Lackner, F. Laggner, A. Lahtinen, P.T. Lang, P. Lauber, N. Leuthold, L. Li, J. Likonen, O. Linder, B. Lipschultz, Y. Liu, A. Lohs, Z. Lu, T. Luda di Cortemiglia, N.C. Luhmann, T. Lunt, A. Lyssoivan, T. Maceina, J. Madsen, A. Magnanimo, H. Maier, J. Mailloux, R. Maingi, O. Maj, E. Maljaars, P. Manas, A. Mancini, A. Manhard, P. Mantica, M. Mantsinen, P. Manz, M. Maraschek, C. Marchetto, L. Marrelli, P. Martin, A. Martitsch, F. Matos, M. Mayer, M.-L. Mayoral, D. Mazon, P.J. McCarthy, R. McDermott, R. Merkel, A. Merle, D. Meshcheriakov, H. Meyer, D. Milanesio, P. Molina Cabrera, F. Monaco, M. Muraca, F. Nabais, V. Naulin, R. Nazikian, R.D. Nem, A. Nemes-Czopf, G. Neu, R. Neu, A.H. Nielsen, S.K. Nielsen, T. Nishizawa, M. Nocente, J.-M. Noterdaeme, I. Novikau, S. Nowak, M. Oberkofler, R. Ochoukov, J. Olsen, F. Orain, F. Palermo, O. Pan, G. Papp, I. Paradela Perez, A. Pau, G. Pautasso, C. Paz-Soldan, P. Petersson, P. Piovesan, C. Piron, U. Plank, B. Plaum, B. Plöck, V. Plyusnin, G. Pokol, E. Poli, L. Porte, T. Pütterich, M. Ramisch, J. Rasmussen, G. Ratta, S. Ratynskaia, G. Raupp, D. Réfy, M. Reich, F. Reimold, D. Reiser, M. Reisner, D. Reiter, T. Ribeiro, R. Riedl, J. Riesch, D. Rittich, J.F. Rivero Rodriguez, G. Rocchi, P. Rodriguez-Fernandez, M. Rodriguez-Ramos, V. Rohde, G. Ronchi, A. Ross, M. Rott, M. Rubel, D.A. Ryan, F. Ryter, S. Saarelma, M. Salewski, A. Salmi, O. Samoylov, L. Sanchis Sanchez, J. Santos, O. Sauter, G. Schall, K. Schlüter, K. Schmid, O. Schmitz, P.A. Schneider, R. Schrittwieser, M. Schubert, C. Schuster, T. Schwarz-Selinger, J. Schweinzer, E. Seliunin, A. Shabbir, A. Shalpegin, S. Sharapov, U. Sheikh, A. Shevelev, G. Sias, M. Siccinio, B. Sieglin, A. Sigalov, A. Silva, C. Silva, D. Silvagni, J. Simpson, S. Sipilä, E. Smigelskis, A. Snicker, E. Solano, C. Sommariva, C. Sozzi, G. Spizzo, M. Spolaore, A. Stegmeir, M. Stejner, J. Stober, E. Strumberge, G. Suarez Lopez, H.-J. Sun, W. Suttrop, E. Sytova, T. Szepesi, B. Tál, T. Tala, G. Tardini, M. Tardocchi, D. Terranova, M. Teschke, E. Thorén, W. Tierens, D. Told, W. Treutterer, G. Trevisan, E. Trier, M. Tripský, M. Usoltceva, M. Valisa, M. Valovic, M. van Zeeland, F. Vannini, B. Vanovac, P. Varela, S. Varoutis, N. Vianello, J. Vicente, G. Verdoolaege, T. Vierle, E. Viezzer, I. Voitsekhovitch, U. von Toussaint, D. Wagner, X. Wang, M. Weiland, A.E. White, M. Willensdorfer, B. Wiringer, M. Wischmeier, R. Wolf, E. Wolfrum, Q. Yang, Q. Yu, R. Zagórski, I. Zammuto, T. Zehetbauer, W. Zhang, W. Zholobenko, M. Zilker, A. Zito, H. Zohm, S. Zoletnik, the EUROfusion MST1 Team, Max-Planck-Institut für Plasmaphysik [Garching] (IPP), Institut de Recherche sur la Fusion par confinement Magnétique (IRFM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Aix Marseille Université (AMU), Laboratoire de Physique des Plasmas (LPP), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École polytechnique (X)-Sorbonne Université (SU)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), EUROfusion MST1 Team, Barcelona Supercomputing Center, Department of Applied Physics, Aalto-yliopisto, Aalto University, Stroth, U, Aguiam, D, Alessi, E, Angioni, C, Arden, N, Parra, R, Artigues, V, Asunta, O, Balden, M, Bandaru, V, Banon-Navarro, A, Behler, K, Bergmann, A, Bergmann, M, Bernardo, J, Bernert, M, Biancalani, A, Bielajew, R, Bilato, R, Birkenmeier, G, Blanken, T, Bobkov, V, Bock, A, Body, T, Bolzonella, T, Bonanomi, N, Bortolon, A, Boswirth, B, Bottereau, C, Bottino, A, Van Den Brand, H, Brenzke, M, Brezinsek, S, Brida, D, Brochard, F, Bruhn, C, Buchanan, J, Buhler, A, Burckhart, A, Camenen, Y, Cannas, B, Megias, P, Carlton, D, Carr, M, Carvalho, P, Castaldo, C, Cavedon, M, Cazzaniga, C, Challis, C, Chankin, A, Cianfarani, C, Clairet, F, Coda, S, Coelho, R, Coenen, J, Colas, L, Conway, G, Costea, S, Coster, D, Cote, T, Creely, A, Croci, G, Zabala, D, Cseh, G, Czarnecka, A, Cziegler, I, D'Arcangelo, O, Molin, A, David, P, Day, C, De Baar, M, De Marne, P, Delogu, R, Denk, S, Denner, P, Di Siena, A, Palacios Duran, J, Dunai, D, Drenik, A, Dreval, M, Drube, R, Dunne, M, Duval, B, Dux, R, Eich, T, Elgeti, S, Encheva, A, Engelhardt, K, Erdos, B, Erofeev, I, Esposito, B, Fable, E, Faitsch, M, Fantz, U, Farnik, M, Faugel, H, Felici, F, Ficker, O, Fietz, S, Figueredo, A, Fischer, R, Ford, O, Frassinetti, L, Froschle, M, Fuchert, G, Fuchs, J, Funfgelder, H, Futatani, S, Galazka, K, Galdon-Quiroga, J, Escola, D, Gallo, A, Gao, Y, Garavaglia, S, Munoz, M, Geiger, B, Giannone, L, Gibson, S, Gil, L, Giovannozzi, E, Gloggler, S, Gobbin, M, Martin, J, Goodman, T, Gorini, G, Gorler, T, Gradic, D, Granucci, G, Grater, A, Greuner, H, Griener, M, Groth, M, Gude, A, Guimarais, L, Gunter, S, Haas, G, Hakola, A, Ham, C, Happel, T, Den Harder, N, Harrer, G, Harrison, J, Hauer, V, Hayward-Schneider, T, Heinemann, B, Hellsten, T, Henderson, S, Hennequin, P, Herrmann, A, Heyn, E, Hitzler, F, Hobirk, J, Hofler, K, Holm, J, Holzl, M, Hopf, C, Horvath, L, Hoschen, T, Houben, A, Hubbard, A, Huber, A, Hunger, K, Igochine, V, Iliasova, M, Ilkei, T, Bjork, K, Ionita-Schrittwieser, C, Ivanova-Stanik, I, Jacob, W, Jaksic, N, Janky, F, Jansen Van Vuuren, A, Jardin, A, Jaulmes, F, Jenko, F, Jensen, T, Joffrin, E, Kallenbach, A, Kalvin, S, Kantor, M, Kappatou, A, Kardaun, O, Karhunen, J, Kasemann, C, Kasilov, S, Kendl, A, Kernbichler, W, Khilkevitch, E, Kirk, A, Hansen, S, Klevarova, V, Kocsis, G, Koleva, M, Komm, M, Kong, M, Kramer-Flecken, A, Krieger, K, Krivska, A, Kudlacek, O, Kurki-Suonio, T, Kurzan, B, Labit, B, Lackner, K, Laggner, F, Lahtinen, A, Lang, P, Lauber, P, Leuthold, N, Li, L, Likonen, J, Linder, O, Lipschultz, B, Liu, Y, Lohs, A, Lu, Z, Luda Di Cortemiglia, T, Luhmann, N, Lunt, T, Lyssoivan, A, Maceina, T, Madsen, J, Magnanimo, A, Maier, H, Mailloux, J, Maingi, R, Maj, O, Maljaars, E, Manas, P, Mancini, A, Manhard, A, Mantica, P, Mantsinen, M, Manz, P, Maraschek, M, Marchetto, C, Marrelli, L, Martin, P, Martitsch, A, Matos, F, Mayer, M, Mayoral, M, Mazon, D, Mccarthy, P, Mcdermott, R, Merkel, R, Merle, A, Meshcheriakov, D, Meyer, H, Milanesio, D, Cabrera, P, Monaco, F, Muraca, M, Nabais, F, Naulin, V, Nazikian, R, Nem, R, Nemes-Czopf, A, Neu, G, Neu, R, Nielsen, A, Nielsen, S, Nishizawa, T, Nocente, M, Noterdaeme, J, Novikau, I, Nowak, S, Oberkofler, M, Ochoukov, R, Olsen, J, Orain, F, Palermo, F, Pan, O, Papp, G, Perez, I, Pau, A, Pautasso, G, Paz-Soldan, C, Petersson, P, Piovesan, P, Piron, C, Plank, U, Plaum, B, Plock, B, Plyusnin, V, Pokol, G, Poli, E, Porte, L, Putterich, T, Ramisch, M, Rasmussen, J, Ratta, G, Ratynskaia, S, Raupp, G, Refy, D, Reich, M, Reimold, F, Reiser, D, Reisner, M, Reiter, D, Ribeiro, T, Riedl, R, Riesch, J, Rittich, D, Rodriguez, J, Rocchi, G, Rodriguez-Fernandez, P, Rodriguez-Ramos, M, Rohde, V, Ronchi, G, Ross, A, Rott, M, Rubel, M, Ryan, D, Ryter, F, Saarelma, S, Salewski, M, Salmi, A, Samoylov, O, Sanchez, L, Santos, J, Sauter, O, Schall, G, Schluter, K, Schmid, K, Schmitz, O, Schneider, P, Schrittwieser, R, Schubert, M, Schuster, C, Schwarz-Selinger, T, Schweinzer, J, Seliunin, E, Shabbir, A, Shalpegin, A, Sharapov, S, Sheikh, U, Shevelev, A, Sias, G, Siccinio, M, Sieglin, B, Sigalov, A, Silva, A, Silva, C, Silvagni, D, Simpson, J, Sipila, S, Smigelskis, E, Snicker, A, Solano, E, Sommariva, C, Sozzi, C, Spizzo, G, Spolaore, M, Stegmeir, A, Stejner, M, Stober, J, Strumberge, E, Lopez, G, Sun, H, Suttrop, W, Sytova, E, Szepesi, T, Tal, B, Tala, T, Tardini, G, Tardocchi, M, Terranova, D, Teschke, M, Thoren, E, Tierens, W, Told, D, Treutterer, W, Trevisan, G, Trier, E, Tripsky, M, Usoltceva, M, Valisa, M, Valovic, M, Van Zeeland, M, Vannini, F, Vanovac, B, Varela, P, Varoutis, S, Vianello, N, Vicente, J, Verdoolaege, G, Vierle, T, Viezzer, E, Voitsekhovitch, I, Von Toussaint, U, Wagner, D, Wang, X, Weiland, M, White, A, Willensdorfer, M, Wiringer, B, Wischmeier, M, Wolf, R, Wolfrum, E, Yang, Q, Yu, Q, Zagorski, R, Zammuto, I, Zehetbauer, T, Zhang, W, Zholobenko, W, Zilker, M, Zito, A, Zohm, H, and Zoletnik, S

Subjects
Nuclear and High Energy Physics, Asdex Upgrade, confinement, ELLM-free discharges, sol, Computer science, Nuclear engineering, ALCATOR C-MOD, UPPER DIVERTOR, ASDEX Upgrade, Physics::Plasma Physics, [PHYS.PHYS.PHYS-PLASM-PH]Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph], Simulació per ordinador, alcator c-mod, ddc:530, upper divertor, ELLM-free discharge, SOL, Basis (linear algebra), Physics, turbulence, transition, h-mode plasmas, Condensed Matter Physics, ddc, Informàtica::Aplicacions de la informàtica::Aplicacions informàtiques a la física i l‘enginyeria [Àrees temàtiques de la UPC], Fusion reactors, Physics and Astronomy, CONFINEMENT MODES, H-MODE PLASMAS, Physics::Space Physics, Nuclear fusion, TURBULENCE, ddc:620, confinement modes, TRANSITION
Abstract

An overview of recent results obtained at the tokamak ASDEX Upgrade (AUG) is given. A work flow for predictive profile modelling of AUG discharges was established which is able to reproduce experimental H-mode plasma profiles based on engineering parameters only. In the plasma center, theoretical predictions on plasma current redistribution by a dynamo effect were confirmed experimentally. For core transport, the stabilizing effect of fast ion distributions on turbulent transport is shown to be important to explain the core isotope effect and improves the description of hollow low-Z impurity profiles. The L–H power threshold of hydrogen plasmas is not affected by small helium admixtures and it increases continuously from the deuterium to the hydrogen level when the hydrogen concentration is raised from 0 to 100%. One focus of recent campaigns was the search for a fusion relevant integrated plasma scenario without large edge localised modes (ELMs). Results from six different ELM-free confinement regimes are compared with respect to reactor relevance: ELM suppression by magnetic perturbation coils could be attributed to toroidally asymmetric turbulent fluctuations in the vicinity of the separatrix. Stable improved confinement mode plasma phases with a detached inner divertor were obtained using a feedback control of the plasma β. The enhanced Dα H-mode regime was extended to higher heating power by feedback controlled radiative cooling with argon. The quasi-coherent exhaust regime was developed into an integrated scenario at high heating power and energy confinement, with a detached divertor and without large ELMs. Small ELMs close to the separatrix lead to peeling-ballooning stability and quasi continuous power exhaust. Helium beam density fluctuation measurements confirm that transport close to the separatrix is important to achieve the different ELM-free regimes. Based on separatrix plasma parameters and interchange-drift-Alfvén turbulence, an analytic model was derived that reproduces the experimentally found important operational boundaries of the density limit and between L- and H-mode confinement. Feedback control for the X-point radiator (XPR) position was established as an important element for divertor detachment control. Stable and detached ELM-free phases with H-mode confinement quality were obtained when the XPR was moved 10 cm above the X-point. Investigations of the plasma in the future flexible snow-flake divertor of AUG by means of first SOLPS-ITER simulations with drifts activated predict beneficial detachment properties and the activation of an additional strike point by the drifts. This work has been carried out within the framework of the EUROfusion Consortium and has received funding from the Euratom research and training programme 2014–2018 and 2019–2020 under Grant Agreement No. 633053. The views and opinions expressed herein do not necessarily reflect those of the European Commission. Peer Reviewed "Article signat per més de 50 autors/es: U. Stroth, D. Aguiam, E. Alessi, C. Angioni, N. Arden, R. Arredondo Parra, V. Artigues, O. Asunta, M. Balden, V. Bandaru, A. Banon-Navarro, K. Behler, A. Bergmann, M. Bergmann, J. Bernardo, M. Bernert, A. Biancalani, R. Bielajew, R. Bilato, G. Birkenmeier, T. Blanken, V. Bobkov, A. Bock, T. Body, T. Bolzonella, N. Bonanomi, A. Bortolon, B. Böswirth, C. Bottereau, A. Bottino, H. van den Brand, M. Brenzke, S. Brezinsek, D. Brida, F. Brochard, C. Bruhn, J. Buchanan, A. Buhler, A. Burckhart, Y. Camenen, B. Cannas, P. Cano Megias, D. Carlton, M. Carr, P. Carvalho, C. Castaldo, M. Cavedon, C. Cazzaniga, C. Challis, A. Chankin, C. Cianfarani, F. Clairet, S. Coda, R. Coelho, J.W. Coenen, L. Colas, G. Conway, S. Costea, D. Coster, T. Cote, A.J. Creely, G. Croci, D.J. Cruz Zabala, G. Cseh, A. Czarnecka, I. Cziegler, O. D'Arcangelo, A. Dal Molin, P. David, C. Day, M. de Baar, P. de Marné, R. Delogu, S. Denk, P. Denner, A. Di Siena, J.J. Dominguez Palacios Durán, D. Dunai, A. Drenik, M. Dreval, R. Drube, M. Dunne, B.P. Duval, R. Dux, T. Eich, S. Elgeti, A. Encheva, K. Engelhardt, B. Erdös, I. Erofeev, B. Esposito, E. Fable, M. Faitsch, U. Fantz, M. Farnik, H. Faugel, F. Felici, O. Ficker, S. Fietz, A. Figueredo, R. Fischer, O. Ford, L. Frassinetti, M. Fröschle, G. Fuchert, J.C. Fuchs, H. Fünfgelder, S. Futatani, K. Galazka, J. Galdon-Quiroga, D. Gallart Escolà, A. Gallo10, Y. Gao11, S. Garavaglia3, M. Garcia Muñoz16, B. Geiger21, L. Giannone1, S. Gibson32, L. Gil2, E. Giovannozzi18, S. Glöggler1, M. Gobbin8, J. Gonzalez Martin, T. Goodman, G. Gorini, T. Görler, D. Gradic, G. Granucci, A. Gräter, H. Greuner, M. Griener, M. Groth, A. Gude, L. Guimarais, S. Günter, G. Haas, A.H. Hakola, C. Ham, T. Happel, N. den Harder, G. Harrer, J. Harrison, V. Hauer, T. Hayward-Schneider, B. Heinemann, T. Hellsten, S. Henderson, P. Hennequin, A. Herrmann, E. Heyn, F. Hitzler, J. Hobirk, K. Höfler, J.H. Holm, M. Hölzl, C. Hopf, L. Horvath, T. Höschen, A. Houben, A. Hubbard, A. Huber, K. Hunger, V. Igochine, M. Iliasova, T. Ilkei, K. Insulander Björk, C. Ionita-Schrittwieser, I. Ivanova-Stanik, W. Jacob, N. Jaksic, F. Janky, A. Jansen van Vuuren, A. Jardin, F. Jaulmes, F. Jenko, T. Jensen, E. Joffrin, A. Kallenbach, S. Kálvin, M. Kantor, A. Kappatou, O. Kardaun, J. Karhunen4, C.-P. Käsemann, S. Kasilov, A. Kendl, W. Kernbichler, E. Khilkevitch, A. Kirk, S. Kjer Hansen, V. Klevarova, G. Kocsis, M. Koleva, M. Komm, M. Kong, A. Krämer-Flecken, K. Krieger, A. Krivska, O. Kudlacek, T. Kurki-Suonio, B. Kurzan, B. Labit, K. Lackner, F. Laggner, A. Lahtinen, P.T. Lang, P. Lauber, N. Leuthold, L. Li, J. Likonen, O. Linder, B. Lipschultz, Y. Liu, A. Lohs, Z. Lu, T. Luda di Cortemiglia, N.C. Luhmann, T. Lunt, A. Lyssoivan, T. Maceina, J. Madsen, A. Magnanimo, H. Maier, J. Mailloux, R. Maingi, O. Maj, E. Maljaars, P. Manas, A. Mancini, A. Manhard, P. Mantica, M. Mantsinen, P. Manz, M. Maraschek, C. Marchetto, L. Marrelli, P. Martin, A. Martitsch, F. Matos, M. Mayer, M.-L. Mayoral, D. Mazon, P.J. McCarthy, R. McDermott, R. Merkel, A. Merle, D. Meshcheriakov, H. Meyer, D. Milanesio, P. Molina Cabrera, F. Monaco, M. Muraca, F. Nabais, V. Naulin, R. Nazikian, R.D. Nem, A. Nemes-Czopf, G. Neu, R. Neu, A.H. Nielsen, S.K. Nielsen, T. Nishizawa, M. Nocente, J.-M. Noterdaeme, I. Novikau, S. Nowak, M. Oberkofler, R. Ochoukov, J. Olsen, F. Orain, F. Palermo, O. Pan, G. Papp, I. Paradela Perez, A. Pau, G. Pautasso, C. Paz-Soldan, P. Petersson, P. Piovesan, C. Piron, U. Plank, B. Plaum, B. Plöck, V. Plyusnin, G. Pokol, E. Poli, L. Porte, T. Pütterich, M. Ramisch, J. Rasmussen, G. Ratta, S. Ratynskaia, G. Raupp, D. Réfy, M. Reich1, F. Reimold, D. Reiser, M. Reisner, D. Reiter, T. Ribeiro, R. Riedl, J. Riesch, D. Rittich, J.F. Rivero Rodriguez, G. Rocchi, P. Rodriguez-Fernandez, M. Rodriguez-Ramos, V. Rohde, G. Ronchi, A. Ross, M. Rott, M. Rubel, D.A. Ryan, F. Ryter, S. Saarelma, M. Salewski, A. Salmi, O. Samoylov, L. Sanchis Sanchez, J. Santos, O. Sauter, G. Schall, K. Schlüter, K. Schmid, O. Schmitz, P.A. Schneider, R. Schrittwieser, M. Schubert, C. Schuster, T. Schwarz-Selinger, J. Schweinzer, E. Seliunin, A. Shabbir, A. Shalpegin, S. Sharapov, U. Sheikh, A. Shevelev, G. Sias, M. Siccinio, B. Sieglin, A. Sigalov, A. Silva, C. Silva, D. Silvagni, J. Simpson, S. Sipilä, E. Smigelskis, A. Snicker, E. Solano, C. Sommariva, C. Sozzi, G. Spizzo, M. Spolaore, A. Stegmeir, M. Stejner, J. Stober, E. Strumberge1, G. Suarez Lopez, H.-J. Sun, W. Suttrop, E. Sytova, T. Szepesi, B. Tál, T. Tala, G. Tardini, M. Tardocchi, D. Terranova, M. Teschke, E. Thorén, W. Tierens, D. Told, W. Treutterer, G. Trevisan, E. Trier, M. Tripský, M. Usoltceva, M. Valisa, M. Valovic, M. van Zeeland, F. Vannini, B. Vanovac, P. Varela, S. Varoutis, N. Vianello, J. Vicente, G. Verdoolaege, T. Vierle, E. Viezzer, I. Voitsekhovitch, U. von Toussaint, D. Wagner, X. Wang, M. Weiland, A.E. White, M. Willensdorfer, B. Wiringer, M. Wischmeier, R. Wolf, E. Wolfrum, Q. Yang, Q. Yu, R. Zagórski, I. Zammuto, T. Zehetbauer, W. Zhang, W. Zholobenko, M. Zilker, A. Zito, H. Zohm, S. Zoletnik and the EUROfusion MST1 Team "

Published
2022

45. WATER PRODUCTION FROM HYDRATED SULFATES ON MARS. A GEOLOGICAL AND TECHNICAL ASSESSMENT.

Author

Gustavo Jamanca-Lino and Guevara, Clairet Guerra

Subjects
*MARS (Planet), *ROCKET fuel, *ALPHA rays, *X-ray spectrometers, *SULFATES
Abstract

The extraction and utilization of planetary materials in situ are of utmost importance to establish a sustainable human presence on Mars. Among these resources, water stands out as the most valuable due to its potential for producing rocket propellants and supporting life systems for astronauts. This research delves into the water resources in Meridiani Planum, an equatorial region where the presence of hydrated sulfates has been confirmed. Leveraging data from the Opportunity Rover and its advanced instruments--the Alpha Particle X-Ray Spectrometer (APXS) and the Miniature Thermal Emission Spectrometer (Mini-TES)--chemical and mineralogical information were processed and classified using statistical methods. The authors go beyond data analysis, presenting a comprehensive high-level concept for acquiring the ore, mineral processing, and water extraction through dehydration techniques. Excavation and physical preparation are examined, incorporating crushing and beneficiation stages. Furthermore, the work includes calculating the temperature, enthalpy, Gibbs energy and kinetic for sulfates dehydration. The outcomes are highlighted through a conceptual architecture, offering estimations regarding mineral throughput for a pilot plant capable of supplying sufficient water to sustain six astronauts throughout an entire Martian year. This study sets a foundation for future endeavours in realizing the ambitious goal of establishing a selfsustaining human presence on Mars. [ABSTRACT FROM AUTHOR]

Published
2023
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46. CEA contribution to the ITER ICRH antenna design

Author

Bernard, J.M., Argouarch, A., Berger-By, G., Brun, C., Clairet, F., Colas, L., Dechelle, C., Durodié, F., Firdaouss, M., Ferlay, F., Giacalone, J.C., Hillairet, J., Jacquot, J., Keller, D., Milanesio, D., Missirlian, M., Shannon, M., and Simonetto, A.

Published
2013
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47. Status of the ITER Ion Cyclotron H&CD system

Author

Lamalle, P., Beaumont, B., Kazarian, F., Gassmann, T., Agarici, G., Ajesh, P., Alonzo, T., Arambhadiya, B., Argouarch, A., Bamber, R., Berger-By, G., Bernard, J.-M., Brun, C., Carpentier, S., Clairet, F., Colas, L., Courtois, X., Davis, A., Dechelle, C., Doceul, L., Dumortier, P., Durodié, F., Ferlay, F., Firdaouss, M., Fredd, E., Giacalone, J.-C., Goulding, R., Greenough, N., Grine, D., Hancock, D., Hari, J.V.S., Hillairet, J., Hosea, J., Huygen, S., Jacquinot, J., Jacquot, J., Kaye, A.S., Keller, D., Kyrytsya, V., Lockley, D., Louche, F., Machchhar, H., Manon, E., Mantel, N., Martin, R., McCarthy, M., Messiaen, A., Meunier, L., Milanesio, D., Missirlian, M., Mohan, K., Mukherjee, A., Nightingale, M., Patadia, D., Patel, A.M., Perrollaz, G., Peters, B., Pitts, R., Porton, M., Rajnish, K., Rasmussen, D., Rathi, D., Sanabria, R., Sartori, R., Shannon, M., Simonetto, A., Singh, R., Suthar, G., Swain, D., Thomas, P., Tigwell, P., Trivedi, R.G., Vervier, M., Vrancken, M., Wilson, D., and Winkler, K.

Published
2013
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48. Persistent Coronavirus Disease 2019 (COVID-19) in an Immunocompromised Host Treated by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-Specific Monoclonal Antibodies

Author

Anne Laure Clairet, Ana Berceanu, Laurie Spehner, Etienne Daguindau, Solène Marty-Quinternet, Karine Lacombe, Benoit Bailly, Kevin Bouiller, Jean-Laurent Casanova, Julien Puech, Sandrine Imbeaud, Quentin Lepiller, Marie Kroemer, Pauline Roux, Brigitte Autran, Catherine Chirouze, Xavier de Lamballerie, David Veyer, Paul Bastard, Fanny Angelot Delettre, Olivier Hermine, Hélène Péré, Nicolas Robillard, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Génomique fonctionnelle des tumeurs solides = Functional Genomics of Solid Tumors [CRC] (FunGeST), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Service d'Hématologie [CHRU Besançon], Hôpital JeanMinjoz, LITTORAL (LITTORAL), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Unité des Virus Emergents (UVE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Human genetics of infectious diseases : Mendelian predisposition (Equipe Inserm U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Rockefeller University [New York], Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre d'Immunologie et des Maladies Infectieuses (CIMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), CHU Pitié-Salpêtrière [AP-HP], Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) (RIGHT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS BFC)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (UR 3181) (CEF2P / CARCINO), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Laboratoire Chrono-environnement (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Centre hospitalier Lons le Saunier, Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), Etablissement français du sang [Bourgogne-Franche-Comté] (EFS BFC), and Howard Hughes Medical Institute (HHMI)

Subjects
Microbiology (medical), 0303 health sciences, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), 030306 microbiology, business.industry, Host (biology), medicine.drug_class, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), [SDV]Life Sciences [q-bio], Monoclonal antibody, Virology, 03 medical and health sciences, 0302 clinical medicine, Infectious Diseases, Medicine, 030212 general & internal medicine, business
Abstract

International audience; No abstract available

Published
2022

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