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The second edition of this essential work presents how to diagnose, treat and develop an appropriate management plan for patients with chronic kidney disease (CKD). Significantly updated chapters cover the fundamental sciences associated with CKD, its clinical assessment, evaluation, management of risk factors, along with cardiovascular disease in the context of CKD. Detailed insight is provided on how to assess for and manage a variety of CKD complications and special circumstances in CKD patients. The path to renal replacement therapy is also thoroughly described. New topics featured include associated rheumatic and electrolyte disorders. Furthermore, diagnostic and therapeutic approaches are presented according to the latest staging system for CKD, with patient care being discussed separately for each disease stage. The book also recognizes the needs of busy clinicians by including helpful boxes summarizing the evidence on diagnostic and therapeutic issues and practice pearls based upon the latest guidelines.Management of Chronic Kidney Disease: A Clinician's Guide is a comprehensive practically applicable guide to the management of patients with CKD. Its didactic features enable the reader to quickly identify the key points covered and disseminate the information they require, making it a valuable resource for all practicing and trainee medical practitioners who encounter these patients..

Chronic Failures: Kidneys, Regimes of Care and the Mexican State is about Chronic Kidney Disease (CKD) and the relentless search for renal care lived out in the context of poverty, inequality and uneven welfare arrangements. Based on ethnographic research conducted in the state of Jalisco, this book documents the routes uninsured Mexican patients take in order to access resource intensive biotechnical treatments, that is, different modes of dialysis and organ transplantation. It argues that these routes are normalized, bureaucratically, socially and epidemiologically, and turned into a locus for exploitation and profit. Without a coherent logic of healthcare access, negotiating regimes of renal care has catastrophic consequences for those with the least resources to expend in that effort. In carrying both the costs and the burden of care, the practices of patients without entitlement offer a critical vantage point on the interplay between the state, markets in healthcare and the sick body.

Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Offering authoritative coverage of all aspects of diagnosing, treating, and preventing the progression of chronic kidney disease (CKD), this highly regarded handbook is an invaluable resource for nephrologists, internists, nurse practitioners, physician assistants, and other healthcare professionals who care for early-stage CKD patients. Incorporating the considerable advances in the field since the previous edition, Handbook of Chronic Kidney Disease Management, 2nd Edition, provides a truly global perspective on managing patients with mild to moderate CKD.

This book presents a comprehensive and instructive management plan for physicians who care for CKD patients. Basic aspects of CKD, clinical assessment, evaluation and management of risk factors, cardiovascular disease in the context of CKD, assessment and management of CKD complications, special circumstances in CKD patients, and the path to renal replacement therapy are all thoroughly covered. Diagnostic and therapeutic approaches are presented according to the latest staging system for CKD, with patient care being discussed separately for each disease stage. The proposed management plan is both “best available evidence based” and “practice based”. The book also recognizes the needs of busy clinicians by including helpful boxes summarizing the evidence on diagnostic and therapeutic issues and practice pearls based on guidelines. The authors are recognized experts from across the world, ensuring global coverage of the problem, and most have participated in writing guidelines on CKD.

Despite significant accomplishments to date, kidney transplantation is a relatively young field in medicine. The shortage of deceased donor organs available for transplantation has led to the need to identify novel strategies to increase the organ donor pool. Due to the armamentarium of agents available to effectively suppress the immune system, this past decade has seen a shift in focus from prevention of rejection to a focus on extending the life of the allograft, with much focus on developing agents and immunosuppression combinations that are less toxic to the transplanted kidney. These concepts provide the framework for this textbook. For the first time in years, agents with novel mechanisms of action are beginning to come to market for use in kidney transplantation, and novel concepts to increase both deceased and living donor organ availability have been adapted by progressive transplant centers. Within the field of living donation, kidney paired donation and single site laparoendoscopic donor nephrectomy are important methods of increasing access to living donor transplantation. Utilization of expanded criteria, donation after cardiac death, hepatitis C positive, and pediatric donor organs are discussed as methods to increase deceased donor transplant opportunities for the more than 90,000 patients currently on the kidney transplant waiting list in the United States alone.

More than 50 years after Haas'first human dialysis, and second edition by incorporating chapters on its history 40 years after Kolfrs pioneering work, a book on the and on the practical aspects. present state of the art cannot be written by one person: The size of the book has almost doubled, partly by obviously it had to be a multi-authored volume. There­ using more illustrations. The inclusion of a number of fore some overlap between chapters and even a few con­ colour reproductions has been made possible by a sup­ troversies between authors became unavoidable. porting grant • of the National Kidney Foundation of we deliberately avoided editorial streamlin­ the Netherlands, which the editors gratefully acknow­ However ing of manuscripts, leaving the authors'personal style ledge. We considered asking several authors to shorten their and personal opinions unaltered as much as possible. We resisted this as it would have delayed the This may make the book more vivid to read and may chapters. sometimes stimulate readers to study a subject in greater publishing date and would possibly have removed much detail from the literature. Additionally, both British and material besides being a painful task for our collea­ American spellings have been kept because of the inter­ gues.

Reviews all the latest basic and clinical research findings With contributions from leading international experts in the field, this book is dedicated to all facets of uremic toxins research, including low molecular weight solutes, protein-bound solutes, and middle molecules. Moreover, it covers everything from basic mass spectrometry research to the latest clinical findings and practices. Uremic Toxins is divided into three sections: Section One, Uremic Toxins, explores the definition, classification, listing, and mass spectrometric analysis of uremic toxins Section Two, Selected Uremic Toxins, describes key uremic toxins, explaining chemical structures, metabolism, analytical methods, plasma levels, toxicity, clinical implications, and removal methods. Among the uremic toxins covered are indoxyl sulfate, asymmetric dimethylarginine, PTH, ß2-microglobulin, and AGEs Section Three, Therapeutic Removal of Uremic Toxins, describes how uremic toxins can be removed by hemodialysis, peritoneal dialysis, and oral sorbent All chapters are based on the authors'thorough review of the literature as well as their own personal laboratory and clinical experience. References at the end of each chapter provide a gateway to the literature in the field. Reviewing all the latest basic and clinical research findings, Uremic Toxins will help bench scientists in nephrology advance their own investigations. It will also help clinicians take advantage of the latest tested and proven treatments for the management of chronic kidney disease.

developed. When I did not identify European colleagues In this rapidly evolving field it is appropriate to update frequently our state of the art knowledge of uremia therapy. who had the expertise who could expend the time and with Hence, this third edition of Replacement of Renal Function whom I could work so smoothly, I began alone. by Dialysis appears before many of its predecessors have Although I was tempted to ask all the same authors as had been destroyed by normal wear and tear over 11 and 6 years written so well previously to contribute again, I realized that the new edition must be revitalized. Accordingly a fraction of use, respectively. The first two editions of this book were designed to be of the authors changed, some new topics have been added integrated comprehensive reviews of the pertinent aspects and others have been deleted. The multinational character of dialysis and related fields with sufficient clarity for the of authorship has been maintained. Existing chapters have novice to learn, yet adequate depth for the expert to rely on been rewritten thoroughly, and new authors have provided them as encyclopedic desk references on renal replacement as requested a full discussion and bibliography in keeping therapy. Based on the favorable readers'comments and with the previous editions.

BELDING H. SCRIBNER The year was 1942 and Will em Kolff was hard at 60's, we encountered exactly the same kind of work perfecting the device that would not only resistance to the concept of chronic dialysis. But revolutionize the treatment of renal failure, but as has happened over and over again in all of more importantly point the way to the develop­ science, the heresy of one decade becomes the ment of the entire field of extracorporeal devices practice of the next - a phenomenon that the in general and cardiac bypass devices in particular. young heretics among the third generation readers The enormity of the impact that Kolffs con­ of this volume should not forget. tribution was to have on medicine was revealed And so, today Drukker, Parsons and Maher retrospectively to me when I recalled that in that have successfully undertaken the very difficult same year, 1942, I was a second year medical task of bringing together in one volume all the student at Stanford University, taking among diverse elements of dialysis therapy. The size of other things, P. J. Hanzlik's required course in the volume reflects not only the magnitude ofthe pharmacology. I have two memories of that interdisciplinary effort that brought about the course. One was the requirement that we students technical and clinical advances, but also the learn to recognize 64 old time drugs by appear­ many clinical and other ramifications of dialysis ance, smell and taste. For better or worse, almost therapy.

The presence of Chronic Kidney Disease (CKD) increases the risk of death from cardiovascular causes and makes the management of heart failure difficult. The coexistence of CKD and heart failure is increasing in prevalence worldwide and requires a unique and subtle approach to patient management. Managing the Kidney in Heart Failure focuses on the therapeutic management of cardio renal patients. Common heart and kidney failure conditions are presented along with treatment scenarios aimed to reduce cardiovascular mortality and preserve kidney function. Co-authored by a Nephrologist and Cardiologist, each chapter of this concise and practical handbook offers a unified perspective to these chronic conditions.

The initial observations of dialytic support were brought from the laboratory and confined to patients with reversible acute renal failure. The thought at that time was one of short term maintenance. It was theorized that removal of waste products from the blood, albeit incomplete and inefficient, might allow these patients time to regenerate damaged tubules and regain renal function. After a dis­ appointing earlier experience in survival, greater sophisti­ cation and broader practice refined the dialysis skills and reduced mortality. It also became apparent that long periods of support were possible and successful attempts were then made in utilizing this technology in patients with chronic renal failure. These early young patients were a very select group who possessed only renal dysfunction and no other systemic involvement. Nonetheless, they demonstrated a one year survival of only 55-64%. There are presently over 80,000 patients on dialytic support in the United States and over 250,000 patients worldwide dependent on artificial replace­ ment. Mortality statistics vary but despite a 20-30% systemic disease involvement and a fifth decade average age in the North American experience, the one year survival has risen to apparently 90%.

Written by an interdisciplinary team of experts, this book contains historical information as well as current update on renal replacement therapy. New technology and techniques are presented in a concise, easy-to-read style that keeps the reader interested.The contributors include physicians who practise uremia therapy since its conception to more recent graduates, along with surgeons, pioneers and physicians who are patients themselves, thus giving readers the broadest perspective.The aim of the book is to update the reader on renal replacement therapy as of 2009. It is a textbook that can be read cover to cover and still serve as a fine reference guide. The book is targeted at anyone interested in kidney replacement therapy, from students and patients to the professorial level.

Chronic kidney disease (CKD) is rapidly becoming a global healthcare problem, with an estimated 10% of the general population affected. As a result, it is becoming increasingly important that primary care physicians and general physicians as well as aspiring nephrologists, have a firm understanding of CKD as well as access to the key information. Practical and highly-accessible, this book provides a comprehensive guide to the understanding and management of patients with CKD. It offers both primary care physicians and non-nephrology specialists an introduction to and insights into the disease. The emphasis is on practical guidance and a focused approach to a number of key topics in the field including epidemiology, diagnosis and management, and the impact of CKD on chronic, non-communicable disease. This is a unique contribution by internationally-renowned experts in the CKD field to update primary care physicians and non-specialists on major issues in this growing global healthcare problem.