105 results on '"Chopra, Chirag"'
Search Results
2. Eco-friendly and safe alternatives for the valorization of shrimp farming waste
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Wani, Atif Khurshid, Akhtar, Nahid, Mir, Tahir ul Gani, Rahayu, Farida, Suhara, Cece, Anjli, Anjli, Chopra, Chirag, Singh, Reena, Prakash, Ajit, El Messaoudi, Noureddine, Fernandes, Clara Dourado, Ferreira, Luiz Fernando Romanholo, Rather, Rauoof Ahmad, and Américo-Pinheiro, Juliana Heloisa Pinê
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- 2024
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3. Replication study identified EFEMP1 association with varicose vein predisposition among Indians
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Mehra, Rohit, Patra, Vikram, Dhillan, Rishi, Sharma, Anuka, Kashyap, Sonal, Rastogi, Garima, Gupta, Love, Singh, Reena, Chopra, Chirag, and Sharma, Varun
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- 2024
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4. Algae-Mediated Removal of Prevalent Genotoxic Antibiotics: Molecular Perspective on Algae-Bacteria Consortia and Bioreactor-Based Strategies
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Wani, Atif Khurshid, ul Gani Mir, Tahir, Akhtar, Nahid, Chopra, Chirag, Bashir, Showkeen Muzamil, Hassan, Shabir, Kumar, Vineet, Singh, Reena, and Américo-Pinheiro, Juliana Heloisa Pinê
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- 2024
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5. Characterization of thermostable carboxypeptidase from high-altitude hot spring metagenome
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Wani, Atif Khurshid, Chopra, Chirag, Ansari, Mushtaq Ahmad, Dar, Mudasir A., Américo-Pinheiro, Juliana Heloisa Pinê, and Singh, Reena
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- 2024
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6. Discovering untapped microbial communities through metagenomics for microplastic remediation: recent advances, challenges, and way forward
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Wani, Atif Khurshid, Akhtar, Nahid, Naqash, Nafiaah, Rahayu, Farida, Djajadi, Djajadi, Chopra, Chirag, Singh, Reena, Mulla, Sikandar I., Sher, Farooq, and Américo-Pinheiro, Juliana Heloisa Pinê
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- 2023
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7. Studies on the ameliorative potential of Rheum webbianum rhizome extracts on 1,2-dimethylhydrazine (DMH) induced colorectal cancer and associated hepatic and haematological abnormalities in swiss albino rats
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Khaja, Umer Majeed, Jabeen, Farhat, Ahmed, Maroof, Rafiq, Asma, Ansar, Ruhban, Javaid, Khushboo, Chopra, Chirag, Singh, Reena, and Ganie, Showkat Ahmad
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- 2024
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8. CRISPR/Cas12a-based biosensors for environmental monitoring and diagnostics
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Wani, Atif Khurshid, Akhtar, Nahid, Mir, Tahir ul Gani, Chopra, Chirag, Singh, Reena, Hong, Jong Chan, and Kadam, Ulhas Sopanrao
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- 2024
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9. Unraveling molecular signatures in rare bone tumors and navigating the cancer pathway landscapes for targeted therapeutics
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Wani, Atif Khurshid, Prakash, Ajit, Sena, Saikat, Akhtar, Nahid, Singh, Reena, Chopra, Chirag, Ariyanti, Esti Endah, Mudiana, Deden, Yulia, Nina Dwi, and Rahayu, Farida
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- 2024
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10. Gut-brain axis and Alzheimer's disease: Therapeutic interventions and strategies
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Singh, Hetender, Chopra, Chirag, Singh, Hemender, Malgotra, Vikas, Khurshid Wani, Atif, Singh Dhanjal, Daljeet, Sharma, Indu, Nepovimova, Eugenie, Alomar, Suliman, Singh, Reena, Sharma, Varun, and Kuca, Kamil
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- 2024
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11. Metagenomics in the fight against zoonotic viral infections: A focus on SARS-CoV-2 analogues
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Wani, Atif Khurshid, Chopra, Chirag, Dhanjal, Daljeet Singh, Akhtar, Nahid, Singh, Himanshu, Bhau, Poorvi, Singh, Anjuvan, Sharma, Varun, Pinheiro, Rafael Silvio Bonilha, Américo-Pinheiro, Juliana Heloisa Pinê, and Singh, Reena
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- 2024
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12. Genome centric engineering using ZFNs, TALENs and CRISPR-Cas9 systems for trait improvement and disease control in Animals
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Wani, Atif Khurshid, Akhtar, Nahid, Singh, Reena, Prakash, Ajit, Raza, Sayed Haidar Abbas, Cavalu, Simona, Chopra, Chirag, Madkour, Mahmoud, Elolimy, Ahmed, and Hashem, Nesrein M.
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- 2023
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13. Prospects of advanced metagenomics and meta-omics in the investigation of phytomicrobiome to forecast beneficial and pathogenic response
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Wani, Atif Khurshid, Akhtar, Nahid, Singh, Reena, Chopra, Chirag, Kakade, Prachi, Borde, Mahesh, Al-Khayri, Jameel M., Suprasanna, Penna, and Zimare, Saurabha B.
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- 2022
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14. Exploring the world hot springs: A bibliometric analysis of global trends in metagenomics research
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Khurshid Wani, Atif, ul Gani Mir, Tahir, Akhtar, Nahid, Chopra, Chirag, Heloisa Pinê Américo-Pinheiro, Juliana, Quadir, Munleef, Kumar Yadav, Krishna, Kumar, Pankaj, Indrayani, IGAA, Krismawati, Amik, Herwati, Anik, and Singh, Reena
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- 2023
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15. Mining microbial tapestry using high-throughput sequencing and In silico analysis of Trehalose synthase (TreS) derived from hot spring metagenome
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Wani, Atif Khurshid, Chopra, Chirag, Singh, Reena, Ahmad, Suhail, and Américo-Pinheiro, Juliana Heloisa Pinê
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- 2023
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16. Targeting eosinophils in chronic respiratory diseases using nanotechnology-based drug delivery
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Sharma, Parvarish, Dhanjal, Daljeet Singh, Chopra, Chirag, Tambuwala, Murtaza M., Sohal, Sukhwinder Singh, van der Spek, Peter J., Sharma, Hari S., and Satija, Saurabh
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- 2022
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17. Bioprospecting culturable and unculturable microbial consortia through metagenomics for bioremediation
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Wani, Atif Khurshid, Akhtar, Nahid, Naqash, Nafiaah, Chopra, Chirag, Singh, Reena, Kumar, Vineet, Kumar, Sunil, Mulla, Sikandar I., and Américo-Pinheiro, Juliana Heloisa Pinê
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- 2022
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18. Nanotechnology based vaccines: Cervical cancer management and perspectives
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Jasrotia, Ridhima, Dhanjal, Daljeet Singh, Bhardwaj, Sonali, Sharma, Parvarish, Chopra, Chirag, Singh, Reena, Kumar, Anupam, Mubayi, Anamika, Kumar, Deepak, Kumar, Raj, and Goyal, Abhineet
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- 2022
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19. Assessing knowledge and awareness levels regarding cervical cancer and HPV vaccination in the Jammu regions.
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Jasrotia, Ridhima, Kashyap, Isha, Suri, Jyotsna, Chopra, Chirag, Wani, Atif Khurshid, Tizro, Nazli, Goyal, Abhineet, and Singh, Reena
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MEDICAL personnel ,HUMAN papillomavirus ,EARLY detection of cancer ,CANCER vaccines ,CONSCIOUSNESS raising ,PAPILLOMAVIRUSES - Abstract
Background and Objectives: Cervical cancer global burden is highly skewed towards poor countries primarily due to lack of awareness, poor screening, and low uptake of prophylactic vaccines. The purpose of our study is to educate and raise awareness among young girls and women about the importance of cervical screening and HPV vaccination. Materials and Methods: The present study, conducted from January 2023 to December 2023, focused on students, teachers, housewives, and healthcare professionals in the Jammu region to assess their awareness of cervical cancer and the HPV vaccine. HPV DNA testing was carried out using the Truenat Real-Time PCR method at Swastik Diagnostic Laboratory, Jammu. Results: Knowledge of cervical cancer, awareness of the HPV virus, and the vaccination status of women were assessed in survey. In the HPV screening test, out of 2,400 women, 106 tested positive for HPV. Among these 106 women, 19% had a high viral load (Ct < 20), 11% had a low viral load (25 = Ct < 30), indicating a low relative concentration of HPV viruses, 40% had a medium viral load (20 = Ct < 25), and 30% had very low viral loads (Ct = 30). Conclusion: These findings highlight the importance of routine cervical screenings, such as Pap smears and HPV tests, for the early detection of cervical cancer. There is an urgent need to implement cervical cancer screening and vaccination programs in the Jammu region. [ABSTRACT FROM AUTHOR]
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- 2024
20. Gemmata obscuriglobus: A connecting link between prokaryotic and eukaryotic cell
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Singh, Saurabh, Rathva, Himanshu K., Sahay, Tulika, Dhanjal, Daljeet S., Chopra, Chirag, and Singh, Reena
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- 2020
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21. Chapter 11 - Revisiting metagenome of South-Asian hot springs for exploration of biomolecules
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Wani, Atif Khurshid, Dhanjal, Daljeet Singh, Chopra, Chirag, and Singh, Reena
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- 2024
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22. Chapter 20 - Nanotechnology at the forefront of liver cancer diagnosis
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Sawhney, Girish, Bhardwaj, Aditya Rattan, Sanu, Kumar, Bhattacharya, Diotima, Singh, Munendra, Dhanjal, Daljeet Singh, Ayub, Anjuman, Wani, Atif Khurshid, Suman, Shikha, Singh, Reena, and Chopra, Chirag
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- 2025
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23. Purification and characterization of CHpro1, a thermotolerant, alkali-stable and oxidation-resisting protease of Chumathang hotspring
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Singh, Reena, Chopra, Chirag, Gupta, Vishnu Kumar, Akhlaq, Bashir, Verma, Vijeshwar, and Rasool, Shafaq
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- 2015
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24. 7 - Insect peptides with antimicrobial effects
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Dhanjal, Daljeet Singh, Chopra, Chirag, Bhardwaj, Sonali, Sharma, Parvarish, Nepovimova, Eugenie, Singh, Reena, and Kuca, Kamil
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- 2023
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25. Chapter 33 - Bioprospecting microalgae for biofuel synthesis: a gateway to sustainable energy
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Akhtar, Nahid, Wani, Atif Khurshid, Singh, Reena, Chopra, Chirag, Mulla, Sikandar I., Sher, Farooq, and Américo-Pinheiro, Juliana Heloisa Pinê
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- 2023
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26. Mycology-Nanotechnology Interface: Applications in Medicine and Cosmetology
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Dhanjal,Daljeet Singh, Mehra,Parul, Bhardwaj,Sonali, Singh,Reena, Sharma,Parvarish, Nepovimova,Eugenie, Chopra,Chirag, and Kuca,Kamil
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International Journal of Nanomedicine - Abstract
Daljeet Singh Dhanjal,1,* Parul Mehra,2,* Sonali Bhardwaj,1,* Reena Singh,1 Parvarish Sharma,3 Eugenie Nepovimova,4 Chirag Chopra,1 Kamil Kuca4,5 1School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab, India; 2Central Research Institute, Kasauli, Himachal Pradesh, India; 3School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India; 4Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, 50003, Czech Republic; 5Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, 50005, Czech Republic*These authors contributed equally to this workCorrespondence: Kamil Kuca, Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, 50003, Czech Republic, Tel +420 603 289 166, Email kamil.kuca@uhk.cz Chirag Chopra, School of Bioengineering and Biosciences, Lovely Professional University, Jalandhar-Delhi GT Road, Phagwara, Punjab, 144411, India, +91-7837815676, Email chirag.18298@lpu.co.inAbstract: In todayâs time, nanotechnology is being utilized to develop efficient products in the cosmetic and pharmaceutical industries. The application of nanotechnology in transforming bioactive material into nanoscale products substantially improves their biocompatibility and enhances their effectiveness, even when used in lower quantities. There is a significant global market potential for these nanoparticles because of which research teams around the world are interested in the advancements in nanotechnology. These recent advances have shown that fungi can synthesize metallic nanoparticles via extra- and intracellular mechanisms. Moreover, the chemical and physical properties of novel metallic nanoparticles synthesised by fungi are improved by regulating the surface chemistry, size, and surface morphology of the nanoparticles. Compared to chemical synthesis, the green synthesis of nanoparticles offers a safe and sustainable approach for developing nanoparticles. Biosynthesised nanoparticles can potentially enhance the bioactivities of different cellular fractions, such as plant extracts, fungal extracts, and metabolites. The nanoparticles synthesised by fungi offer a wide range of applications. Recently, the biosynthesis of nanoparticles using fungi has become popular, and various ways are being explored to maximize nanoparticles synthesis. This manuscript reviews the characteristics and applications of the nanoparticles synthesised using the different taxa of fungi. The key focus is given to the applications of these nanoparticles in medicine and cosmetology.Keywords: fungi, biological application, biosynthesis, nanoparticles, nanotechnology
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- 2022
27. Biogenic Metallic Nanoparticles from Seed Extracts: Characteristics, Properties, and Applications
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Bhardwaj, Kanchan, Chopra, Chirag, Bhardwaj, Prerna, Dhanjal, Daljeet Singh, Singh, Reena, Najda, Agnieszka, Cruz-Martins, Natalia, Singh, Shubhangi, Sharma, Rohit, Kuča, Kamil, and Manickam, Sivakumar
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Article Subject - Abstract
Metal nanoparticles (MNPs) are popular in different research fields due to their unique physical and chemical properties and superior antimicrobial, anticancer, antioxidant, larvicidal, and catalytic potentials. Although conventional wet methods like colloidal synthesis, calcination, and spark ablation for synthesizing MNPs are effective, their synthesis uses an array of reducing and stabilizing agents and gases, making the process tedious. Additionally, metal nanoparticles induce oxidative stress through reactive oxygen species (ROS), showing high toxicity. Research and development in green chemistry have gained momentum and massive attention because of being efficient, clean, economical, environment-friendly, and free of hazardous byproducts. Recently, seed extracts in-lieu of chemical stabilizers and reducing agents have become popular because of the single-step green synthesis of MNPs. Seeds provide the researchers with a cost-effective alternate to other biological methods due to low maintenance costs, culture/growth independence for biomass, and diversity of phytochemicals as reducing and capping agents. Thus, effective green synthesis approaches are considered sustainable for MNP synthesis. This review depicts the literature on the challenges associated with metal and metal oxide nanoparticles and discusses their synthesis using seed extracts. The application section of the review discusses the antimicrobial, anticancer, and larvicidal activities of seed extracted-synthesized metallic nanoparticles. Furthermore, insights into the different biological potentials of the synthesized green MNPs have also been discussed.
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- 2022
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28. List of contributors
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Akhila, Dharnappa Sannejal, Akshaya, Korthusheril Ajayakumar, Amat, Dolamani, Ashajyothi, Mushineni, Bag, Sagar, Banik, Avishek, Behera, Dibyajyoti Uttameswar, Bhat, Mashooqa, Bijalwan, Shraddha, Biswas, Ishita, Chakdar, Hillol, Chopra, Chirag, Das, Abinash, Das, Anupam J., Das, Gargi, Das Mohapatra, Pradeep K., Dash, Stiti Prangya, De, Debjit, Dhal, Paltu Kumar, Dhanjal, Daljeet Singh, Dixit, Sangita, Dwivedi, Nidhi, Gaur, Mahendra, Ghosh, Dipankar, Giri, Abhinash Kumar, Goyal, Arvind Kumar, Gupta, Sanjay Kumar, Hemavathi, Kadabagere Narayanaswamy, Imchen, Madangchanok, Jayaswal, Deepanshu, Katiyar, Amit, Kaur, Punit, Kavitha, Guladahalli Manjunatha, Kerry, Rout George, Khaliq, Bilqueesa, Khatun, Irin, Kumar, Adarsh, Kumavath, Ranjith, Majhi, Sanatan, Mandal, Asit, Middha, Sushil Kumar, Milesh, Ligi, Mitra, Debanjan, Mohapatra, Madhusmita, Mondal, Anupam, Moopantakath, Jamseel, Nayak, Tilak, Patra, A.K., Pradhan, Dibyabhaba, Rajeshwari, Vittal, Ramesh, Nijalingappa, Ramya, Premnath, Rani, Khushboo, Rastogi, Gurdeep, Ravinath, Renuka, Reddy, Alla Devivaraprasad, Reddy, Kampati Kiran Kumar, Sahoo, Lakshman, Saoud, Joseph, Sen, Mitun, Sharma, Tanya, Singh, Harpreet, Singh, Jyoti Prakash, Singh, Reena, Sinha, Nilothpal, Sowmya, Raju, Sreevalsan, Aathira, Subudhi, Enketeswara, Thakur, J.K., Tilgam, Jyotsana, Trivedi, Ankita, Usha, Talambedu, Vasudevan, Karthick, and Wani, Atif Khurshid
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- 2024
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29. List of contributors
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Abutwaibe, K.A., Ayub, Anjuman, Bajhal, Sakshi, Batra, Sonali, Behera, Chittaranjan, Bhardwaj, Aditya Rattan, Bhattacharya, Diotima, Bosio, Gabriela N., Cabrera-Munguía, Denis A., Cai, Yu, Cancino-Bernardi, Juliana, Castillo-Rivera, F., Chavan, Sachin Ganpat, Chen, Haolin, Chopra, Chirag, Chourasia, Manish K., Claudio-Rizo, Jesús A., Costa, Clara Cardoso, de Camargo Tardio, Amanda, Dhanjal, Daljeet Singh, Díaz, Sandra Mendoza, Díaz-López, O., Dong, Xiaochen, Gao, Fan, Gupta, Prem N., Han, Hyo-Won, Jadav, Mahima, Jang, Eue-Soon, Javaid, Aaqib, Joe, Ara, Kakkar, Vandita, Kaur, Amanpreet, Koyappayil, Aneesh, Kulhari, Hitesh, Kumar, Lalit, Kumari, Parina, Kumari, Parveen, Laura Denise, Lopez-Barrera, Lee, Min-Ho, León-Campos, Maria I., Leung, Franco King-Chi, Li, Fang, Liang, Chen, Liu, Zhiming, López-Romero, José Mauricio, Maddheshiya, Shilpa, Manivasagan, Panchanathan, Manzano-Ramírez, Alejandro, Margatho, Júlia Mendonça, Marisetti, Arya Lakshmi, Mártire, Daniel O., Mendez, Nestor Efren, Mendoza-Villafaña, Juan J., Meza-Pardo, I.G., Mishra, Keerti, Mudavath, Shyam Lal, Mujahid, Haroon, Mujahid, Khizra, Nam, Jutaek, Nara, Seema, Nehru, Sangamithra, P, Prasanth, Patricia, Ramirez-Noguera, Ponpandian, Nagamony, Pooja, Deep, Rai, Divya Bharti, Ramamoorthy, Sharmiladevi, Rana, Isra, Rana, Rafquat, Ren, Yikun, Rivas Aiello, María Belén, Roberto, Diaz-Torres, Salado-Leza, D., Sánchez-Campos, D., Sandha, Kamalpreet Kaur, Sanu, Kumar, Saravanan, Nishakavya, Sawhney, Girish, Seo, Sun-Hwa, Sharma, Sumit, Singh, Manisha, Singh, Munendra, Singh, Reena, Sivaselvam, S., Soto, Karen, Suliman, Ivan Hardianto, Suman, Shikha, Sundaramurthy, Anandhakumar, Tewari, Devesh, Tiwari, Amrendra K., Toldo, Gustavo Silveira, Tripathi, Shourya, Veena, Mounasamy, Venkatesan, Jayachandran, Wani, Atif Khurshid, Wong, Wai-Ki, Xin, Junbo, Xu, Bo, Yadav, Pavan K., and Yadav, Pooja
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- 2025
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30. Chapter 15 - Novel Controlled Release Pulmonary Drug Delivery Systems: Current updates and Challenges
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Dhanjal, Daljeet S., Mehta, Meenu, Chopra, Chirag, Singh, Reena, Sharma, Parvarish, Chellappan, Dinesh K., Tambuwala, Murtaza M., Bakshi, Hamid A., Aljabali, Alaa A.A., Gupta, Gaurav, Nammi, Srinivas, Prasher, Parteek, Dua, Kamal, and Satija, Saurabh
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- 2021
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31. Detection of bacterial pathogens and antibiotic residues in chicken meat: a review
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Kumar, Harsh, Bhardwaj, Kanchan, Kaur, Talwinder, Nepovimova, Eugenie, Kuča, Kamil, Kumar, Vinod, Bhatia, Shashi Kant, Dhanjal, Daljeet Singh, Chopra, Chirag, Singh, Reena, Guleria, Shivani, Bhalla, Tek Chand, Verma, Rachna, and Kumar, Dinesh
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multidrug‐resistant bacteria ,chromatography‐based method ,immunology‐based method ,chicken ,molecular‐based methods ,biosensors ,antibiotics - Abstract
Detection of pathogenic microbes as well as antibiotic residues in food animals, especially in chicken, has become a matter of food security worldwide. The association of various pathogenic bacteria in different diseases and selective pressure induced by accumulated antibiotic residue to develop antibiotic resistance is also emerging as the threat to human health. These challenges have made the containment of pathogenic bacteria and early detection of antibiotic residue highly crucial for robust and precise detection. However, the traditional culture-based approaches are well-comprehended for identifying microbes. Nevertheless, because they are inadequate, time-consuming and laborious, these conventional methods are not predominantly used. Therefore, it has become essential to explore alternatives for the easy and robust detection of pathogenic microbes and antibiotic residue in the food source. Presently, different monitoring, as well as detection techniques like PCR-based, assay (nucleic acid)-based, enzyme-linked immunosorbent assays (ELISA)-based, aptamer-based, biosensor-based, matrix-assisted laser desorption/ionization-time of flight mass spectrometry-based and electronic nose-based methods, have been developed for detecting the presence of bacterial contaminants and antibiotic residues. The current review intends to summarize the different techniques and underline the potential of every method used for the detection of bacterial pathogens and antibiotic residue in chicken meat.
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- 2020
32. Phyto-Enrichment of Yogurt to Control Hypercholesterolemia: A Functional Approach.
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Kumar, Harsh, Bhardwaj, Kanchan, Cruz-Martins, Natália, Sharma, Ruchi, Siddiqui, Shahida Anusha, Dhanjal, Daljeet Singh, Singh, Reena, Chopra, Chirag, Dantas, Adriana, Verma, Rachna, Dosoky, Noura S., and Kumar, Dinesh
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YOGURT ,BLOOD cholesterol ,BLOOD circulation ,BETA-glucans ,HUMAN microbiota ,GUT microbiome ,VITAMINS - Abstract
Cholesterol is essential for normal human health, but elevations in its serum levels have led to the development of various complications, including hypercholesterolemia (HC). Cholesterol accumulation in blood circulation formsplaques on artery walls and worsens the individuals' health. To overcome this complication, different pharmacological and non-pharmacological approaches are employed to reduce elevated blood cholesterol levels. Atorvastatin and rosuvastatin are the most commonly used drugs, but their prolonged use leads to several acute side effects. In recent decades, the potential benefit of ingesting yogurt on lipid profile has attracted the interest of researchers and medical professionals worldwide. This review aims to give an overview of the current knowledge about HC and the different therapeutic approaches. It also discusses the health benefits of yogurt consumption and highlights the overlooked phyto-enrichment option to enhance the yogurt's quality. Finally, clinical studies using different phyto-enriched yogurts for HC management are also reviewed. Yogurt has a rich nutritional value, but its processing degrades the content of minerals, vitamins, and other vital constituents with beneficial health effects. The option of enriching yogurt with phytoconstituents has drawn a lot of attention. Different pre-clinical and clinical studies have provided new insights on their benefits on gut microbiota and human health. Thus, the yogurtphyto-enrichment with stanol and β-glucan have opened new paths in functional food industries and found healthy andeffective alternatives for HC all along with conventional treatment approaches. [ABSTRACT FROM AUTHOR]
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- 2022
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33. List of contributors
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Aishwarya, M.S., Ajesh, K., Arun, B., Balakrishnan, Anjali Jayasree, Bhardwaj, Sonali, Chandravarkar, Arunan, Chaudhary, Nitin, Chopra, Chirag, de Melo Franco, Bernadette Dora Gombossy, Dhanjal, Daljeet Singh, Fonseca, Gustavo Graciano, Francis, Feba, Gelinski, Jane Mary Lafayette Neves, George, Benu, Hemanth Kumar, N.K., Jagannath, Shobha, Janardhanan, Prajit, Krishnan, A. Anju, Kuca, Kamil, Kumar, K. Santhosh, Lakshmanan, M. Divya, Lipton, A.P., Megha Rani, N., Nair, Swapna M., Nepovimova, Eugenie, Pilankatta, Rajendra, Pooja, S., Poornachandra Rao, K., Prajosh, P., Rachanamol, R.S., Ramesan, C.K.V., Reiling, Scott, Rejeesh, E.P., Sarika, A.R., Sebastian, Denoj, Selvin, J., Shabeer Ali, H., Sharma, Parvarish, Shishupala, S., Singh, Reena, Skariyachan, Sinosh, Somashekaraiah, Rakesh, Somasundaran, Aswathi Kodenchery, Sreejith, K., Sreenivasa, M.Y., Suchithra, T.V., Swathi Prabhu, B.R., Tripathi, Renu, Verma, Atul, Vinod, N.V., and Wang, Guangshun
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- 2023
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34. List of contributors
- Author
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Aguilar, Cristóbal N., Akhtar, Nahid, Al-Tawaha, Abdel Rahman, Ali, Elham M., Ali, Omar Aweiss, Alves dos Santos, Angela, Alves Júnior, Sérgio Luiz, Américo-Pinheiro, Juliana Heloisa Pinê, Aransiola, S.A., Bastidas Barranco, Marlón José, Behera, Sudhanshu S., Bhattacharya, Sayan, Biswas, Protha, Boro, Manswama, Buitrón, Germán, Bursal, Ercan, Cabello-Galindo, Alejandra, Camargo, Aline Frumi, Chairez, Isaac, Chauhan, Indu, Chibani, Atef, Chopra, Muskaan, Chopra, Chirag, Chávez-González, Mónica L., Das, Pranjal P., Das, Urmimala, Das, Tuyelee, Dehane, Aissa, Dey, Shibam, Dey, Abhijit, Dey, Satarupa, Dhara, Simons, Dongare, Prajwal P., Duarah, Prangan, El-Chaghaby, Ghadir Aly, El-Sheekh, Mostafa M., Elshobary, Mostafa, Fawzy, Mustafa A., Ghorai, Mimosa, Ghosh, Sougata, Ghosh, Arabinda, Giraldo, Liliana, Gomaa, Mohamed, González-Fernández, Cristina, Gurav, Ranjit, Haldar, Dibyajyoti, Hansdah, Bishnupriya, Haq, Ikram ul, Helena dos Santos, Laura, Hwang, Sangchul, Jadhav, Rahul, Jadhav, Jyoti, Kamilya, Priyanka, Kumar, Kondragunta Prasanna, Kumar, Vineet, Kumar, Subrat, Leh-Togi Zobeashia, S.S., Machado-Cepeda, Samanta, Maddela, Naga Raju, Mandal, Sujata, Martínez Gil, José Manuel, Mazumder, Ishanee, Merouani, Slimane, Michelon, William, Moreno-Piraján, Juan Carlos, Mukhtar, Hamid, Mulla, Sikandar I., Nawaz, Ali, Nemdili, Leila, Nongdam, Potshangbam, Panda, Sandeep Kumar, Patel, Hiren K., Patel, Nidhi P., Pathak, Sagarjyoti, Pattnaik, Ritesh, Pawar, Hitesh S., Perarasu, V.T., Purkait, Mihir Kumar, Quijano, Guillermo, Quratulain, Ranjit, Pabbati, Rashad, Sayed, Ravinder, Palvi, Ray, Ramesh C., Reddy, Kondakindi Venkateswar, Rekha, Pawan, Remya, Neelancherry, Reyes, Ricardo Vivas, Rodríguez-Jasso, Rosa M., Rosero-Chasoy, Gilver, Roy, Chandrashish, Ruiz, Héctor A., Samanta, Niladri S., Saravanathamizhan, R., Sarkar, Bishwarup, Satya Sree, Nalam Renuka, Saxena, Rohit, Scapini, Thamarys, Shah, Maulin P., Shaheen, Falak, Shalaby, Emad A., Shanab, Sanaa M.M., Sharma, Vivek, Sharma, Indu, Sher, Farooq, Singh, Soumya, Singh, Shalini, Singh, Reena, Singh, Lovjeet, Sontakke, Ankush D., Taneja, Tanvi, Thongmee, Sirikanjana, Tiwari, Prashnasa, Treichel, Helen, Valekar, Navanath, Verma, Anil Kumar, Vetriselvan, K., Viancelli, Aline, Victor-Ekwebelem, M.O., Wani, Atif Khurshid, and Zambare, Vasudeo
- Published
- 2023
- Full Text
- View/download PDF
35. REVIEW ARTICLE: MICROORGANISMS-DIVERSITY ANALYSIS AND APPROACHES.
- Author
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Dhanjall, Daljeet Singh, Dholel, Shweta, Singh, Reena, and Chopra, Chirag
- Subjects
MICROBIAL communities ,MICROBIAL diversity ,SYMBIOSIS ,NANOTECHNOLOGY ,MINES & mineral resources - Abstract
As microbes are 3.5x10
9 years old dominant species prevailing on this earth in varied places even with temperatures ranging from 10-100°C. Soil life has a continuous interface between minerals and the organic life. The microorganisms regulate the physio-chemical and other biological properties of the ecosystem. The microbial community residing in the soil is, directly and indirectly, involved in various processes like the biogeochemical cycles, symbioses and nutrient recycling. Therefore, to understand the role of these minute creatures in the soil, their microbial diversity plays a critical role. Numerous techniques have been developed to unravel the information about the microbial community. The molecular techniques have made the identification of novel microorganisms convenient and robust. Hence, this review aims to highlight the importance of microbes and microbial diversity and discuss the molecular methods for gaining better insight into the microbes. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF
36. REVIEW ARTICLE: THE GINGER FAMILY: SPICING-UP THE ANTICANCER RESEARCH.
- Author
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Somani, Jigyasa, Dhanjal, Daljeet Singh, Singh, Reena, Satija, Saurabh, and Chopra, Chirag
- Subjects
GINGER ,MEDICINAL plants ,BIOACTIVE compounds ,ANTINEOPLASTIC agents ,CANCER research - Abstract
Cancer is a fatal and severe disease to the humankind. There are various potent and effective sources such as natural herbs which have various bioactive compounds to combat cancer. Zingiber officinale is a perennial herb of the Zingiberaceae family having various medicinal properties as well as anti-oxidant potential. The active secondary metabolites in the ginger contribute to its anti-oxidant and anti-cancer property. Various methods are used in detecting how ginger can be used as an agent to combat diseases. Cytotoxicity and antioxidant assays provide the idea about the cell-viability and anti-oxidant property of ginger. When the production of reactive oxygen species (ROSs) increases in the body, it can have various negative impacts. To nullify these impacts, ginger extract is effective on the cells. The cytotoxic nature and anti-proliferative properties of ginger directly contribute to various cellular mechanisms such as apoptosis which have a significant impact on cancer cells. The results also describe the effect of ginger on free radicals. It is concluded that ginger can be used as an alternative source of anti-cancer drugs as it has been proved to be effective in multiple studies. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
37. Potential Usage of Edible Mushrooms and Their Residues to Retrieve Valuable Supplies for Industrial Applications.
- Author
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Kumar, Harsh, Bhardwaj, Kanchan, Sharma, Ruchi, Nepovimova, Eugenie, Cruz-Martins, Natália, Dhanjal, Daljeet Singh, Singh, Reena, Chopra, Chirag, Verma, Rachna, Abd-Elsalam, Kamel A., Tapwal, Ashwani, Musilek, Kamil, Kumar, Dinesh, and Kuča, Kamil
- Subjects
EDIBLE mushrooms ,INDUSTRIAL applications ,AGRICULTURAL industries ,AGRICULTURAL wastes ,ENVIRONMENTAL protection - Abstract
Currently, the food and agricultural sectors are concerned about environmental problems caused by raw material waste, and they are looking for strategies to reduce the growing amount of waste disposal. Now, approaches are being explored that could increment and provide valueadded products from agricultural waste to contribute to the circular economy and environmental protection. Edible mushrooms have been globally appreciated for their medicinal properties and nutritional value, but during the mushroom production process nearly one-fifth of the mushroom gets wasted. Therefore, improper disposal of mushrooms and untreated residues can cause fungal disease. The residues of edible mushrooms, being rich in sterols, vitamin D2, amino acids, and polysaccharides, among others, makes it underutilized waste. Most of the published literature has primarily focused on the isolation of bioactive components of these edible mushrooms; however, utilization of waste or edible mushrooms themselves, for the production of value-added products, has remained an overlooked area. Waste of edible mushrooms also represents a disposal problem, but they are a rich source of important compounds, owing to their nutritional and functional properties. Researchers have started exploiting edible mushroom by-products/waste for value-added goods with applications in diverse fields. Bioactive compounds obtained from edible mushrooms are being used in media production and skincare formulations. Furthermore, diverse applications from edible mushrooms are also being explored, including the synthesis of biosorbent, biochar, edible films/coating, probiotics, nanoparticles and cosmetic products. The primary intent of this review is to summarize the information related to edible mushrooms and their valorization in developing value-added products with industrial applications. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
38. Contributors
- Author
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Aderibigbe, Blessing A., Ahmad, Wasim, Akbarzadeh, Abolfazl, Al-Dossary, Hanan A., Ali, Abuzar, Alibolandi, Mona, Aljabali, Alaa A.A., Amjad, Saima, Ansari, Mohammad Azam, Bagheri, Elnaz, Bakshi, Hamid A., Bernkop-Schnürch, Andreas, Bhansali, Mitesh, Castro, Guillermo R., Chellappan, Dinesh K., Chopra, Chirag, Cuestas, María L., Dabholkar, Neha, Danafar, Hossein, Davaran, Soodabeh, Devoto, Tomás Brito, Dhanjal, Daljeet S., Dua, Kamal, Dubey, Sunil Kumar, Ebrahimi, Nadereh Golshan, Eghtesad, Mohammad, Faridi, Pouria, Fatima, Zeeshan, Ghosh, Goutam, Govardhane, Sharayu, Gupta, Gaurav, Hameed, Saif, Heydari, Mahsa, Islán, Germán A., Jahanbakhshi, Mehdi, Jalil, Aamir, Jose, Jobin, Konkody, Kiran, Lagoa, Ricardo, Limeres, María J., Marques-da-Silva, Dorinda, Mehr, Javad K., Mehta, Meenu, Mir, Mohammad, Mohammadi, Marzieh, Nammi, Srinivas, Nezhad-Mokhtari, Parinaz, Nosrati, Hamed, Oliaie, Hadi, Prasher, Parteek, Preetha, H.S., Rahimi, Hossein, Ramezani, Mohammad, Rath, Goutam, Rehman, Suriya, Rodrigues, Iola Sandria, Sahu, Dipak Kumar, Salahpour-Anarjan, Fatemeh, Sameiyan, Elham, Satija, Saurabh, Serajuddin, M., Shahrousvand, Mohammad, Shahrousvand, Mohsen, Shariatinia, Zahra, Sharifi, Mojtaba, Sharma, Parvarish, Shende, Pravin, Silva, João S., Singh, Reena, Singhvi, Gautam, Swetha, P., Tambuwala, Murtaza M., Tangestanizadeh, Samaneh, Toscanini, María A., Vatankhah, Ramin, and Yaqoob, Muhammad
- Published
- 2021
- Full Text
- View/download PDF
39. Applications of Fruit Polyphenols and Their Functionalized Nanoparticles Against Foodborne Bacteria: A Mini Review.
- Author
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Kumar, Harsh, Bhardwaj, Kanchan, Cruz-Martins, Natália, Nepovimova, Eugenie, Oleksak, Patrik, Dhanjal, Daljeet Singh, Bhardwaj, Sonali, Singh, Reena, Chopra, Chirag, Verma, Rachna, Chauhan, Prem Parkash, Kumar, Dinesh, and Kuča, Kamil
- Subjects
FOOD preservatives ,POLYPHENOLS ,FRUIT ,FOODBORNE diseases ,NUTRITIONAL value ,FRUIT extracts ,FOOD contamination - Abstract
The ingestion of contaminated water and food is known to cause food illness. Moreover, on assessing the patients suffering from foodborne disease has revealed the role of microbes in such diseases. Concerning which different methods have been developed for protecting food from microbes, the treatment of food with chemicals has been reported to exhibit an unwanted organoleptic effect while also affecting the nutritional value of food. Owing to these challenges, the demand for natural food preservatives has substantially increased. Therefore, the interest of researchers and food industries has shifted towards fruit polyphenols as potent inhibitors of foodborne bacteria. Recently, numerous fruit polyphenols have been acclaimed for their ability to avert toxin production and biofilm formation. Furthermore, various studies have recommended using fruit polyphenols solely or in combination with chemical disinfectants and food preservatives. Currently, different nanoparticles have been synthesized using fruit polyphenols to curb the growth of pathogenic microbes. Hence, this review intends to summarize the current knowledge about fruit polyphenols as antibacterial agents against foodborne pathogens. Additionally, the application of different fruit extracts in synthesizing functionalized nanoparticles has also been discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
40. Plant Prebiotics and Their Role in the Amelioration of Diseases.
- Author
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Kaur, Amrit Pal, Bhardwaj, Sonali, Dhanjal, Daljeet Singh, Nepovimova, Eugenie, Cruz-Martins, Natália, Kuča, Kamil, Chopra, Chirag, Singh, Reena, Kumar, Harsh, Șen, Fatih, Kumar, Vinod, Verma, Rachna, Kumar, Dinesh, Furneri, Pio Maria, and Fuochi, Virginia
- Subjects
PREBIOTICS ,SHORT-chain fatty acids ,GUT microbiome ,FUNCTIONAL foods ,GARLIC ,FLAXSEED ,LARGE intestine ,DIETARY supplements - Abstract
Prebiotics are either natural or synthetic non-digestible (non-)carbohydrate substances that boost the proliferation of gut microbes. Undigested fructooligosaccharides in the large intestine are utilised by the beneficial microorganisms for the synthesis of short-chain fatty acids for their own growth. Although various food products are now recognized as having prebiotic properties, several others, such as almonds, artichoke, barley, chia seeds, chicory, dandelion greens, flaxseeds, garlic, and oats, are being explored and used as functional foods. Considering the benefits of these prebiotics in mineral absorption, metabolite production, gut microbiota modulation, and in various diseases such as diabetes, allergy, metabolic disorders, and necrotising enterocolitis, increasing attention has been focused on their applications in both food and pharmaceutical industries, although some of these food products are actually used as food supplements. This review aims to highlight the potential and need of these prebiotics in the diet and also discusses data related to the distinct types, sources, modes of action, and health benefits. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
41. Conifer-Derived Metallic Nanoparticles: Green Synthesis and Biological Applications.
- Author
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Bhardwaj, Kanchan, Dhanjal, Daljeet Singh, Sharma, Anirudh, Nepovimova, Eugenie, Kalia, Anu, Thakur, Shabnam, Bhardwaj, Sonali, Chopra, Chirag, Singh, Reena, Verma, Rachna, Kumar, Dinesh, Bhardwaj, Prerna, and Kuča, Kamil
- Subjects
BIOSYNTHESIS ,NANOPARTICLES ,PLANT extracts ,REDUCING agents ,CONIFERS ,SILVER nanoparticles - Abstract
The use of metallic nanoparticles in engineering and biomedicine disciplines has gained considerable attention. Scientists are exploring new synthesis protocols of these substances considering their small size and lucrative antimicrobial potential. Among the most economical techniques of synthesis of metallic nanoparticles via chemical routes, which includes the use of chemicals as metal reducing agents, is considered to generate nanoparticles possessing toxicity and biological risk. This limitation of chemically synthesized nanoparticles has engendered the exploration for the ecofriendly synthesis process. Biological or green synthesis approaches have emerged as an effective solution to address the limitations of conventionally synthesized nanoparticles. Nanoparticles synthesized via biological entities obtained from plant extracts exhibit superior effect in comparison to chemical methods. Recently, conifer extracts have been found to be effective in synthesizing metallic nanoparticles through a highly regulated process. The current review highlights the importance of conifers and its extracts in synthesis of metallic nanoparticles. It also discusses the different applications of the conifer extract mediated metallic nanoparticles. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
42. Plant Fortification of the Diet for Anti-Ageing Effects: A Review.
- Author
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Dhanjal, Daljeet Singh, Bhardwaj, Sonali, Sharma, Ruchi, Bhardwaj, Kanchan, Kumar, Dinesh, Chopra, Chirag, Nepovimova, Eugenie, Singh, Reena, and Kuca, Kamil
- Abstract
Ageing is an enigmatic and progressive biological process which undermines the normal functions of living organisms with time. Ageing has been conspicuously linked to dietary habits, whereby dietary restrictions and antioxidants play a substantial role in slowing the ageing process. Oxygen is an essential molecule that sustains human life on earth and is involved in the synthesis of reactive oxygen species (ROS) that pose certain health complications. The ROS are believed to be a significant factor in the progression of ageing. A robust lifestyle and healthy food, containing dietary antioxidants, are essential for improving the overall livelihood and decelerating the ageing process. Dietary antioxidants such as adaptogens, anthocyanins, vitamins A/D/C/E and isoflavones slow the ageing phenomena by reducing ROS production in the cells, thereby improving the life span of living organisms. This review highlights the manifestations of ageing, theories associated with ageing and the importance of diet management in ageing. It also discusses the available functional foods as well as nutraceuticals with anti-ageing potential. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
43. Non-edible fruit seeds: nutritional profile, clinical aspects, and enrichment in functional foods and feeds.
- Author
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Kumar, Harsh, Dhalaria, Rajni, Guleria, Shivani, Sharma, Ruchi, Kumar, Dinesh, Verma, Rachna, Cruz-Martins, Natália, Dhanjal, Daljeet Singh, Chopra, Chirag, Kaur, Talwinder, Kumar, Vijay, Siddiqui, Shahida Anusha, Manickam, Sivakumar, Cimler, Richard, and Kuca, Kamil
- Abstract
Abstract Nowadays, fruits are gaining high demand due to their promising advantages on human health. Astonishingly, their by-products, that is, seeds and peels, account for 10–35% of fruit weight and are usually thrown as waste after consumption or processing. But it is neglected that fruit seeds also have functional properties and nutritional value, and thus could be utilized for dietary and therapeutic purposes, ultimately reducing the waste burden on the environment. Owing to these benefits, researchers have started to assess the nutritional value of different fruits seeds, in addition to the chemical composition in various bioactive constituents, like carotenoids (lycopene), flavonoids, proteins (bioactive peptides), vitamins, etc., that have substantial health benefits and can be used in formulating different types of food products with noteworthy functional and nutraceutical potential. The current review aims to comprehend the known information of nutritional and phytochemical profiling of non-edible fruits seeds, viz. apple, apricot, avocado, cherry, date, jamun, litchi, longan, mango, and papaya. Additionally, clinical studies conducted on these selected non-edible fruit seed extracts, their safety issues and their enrichment in food products as well as animal feed has also been discussed. This review aims to highlight the potential applications of the non-edible fruit seeds in developing new food products and also provide a viable alternative to reduce the waste disposal issue faced by agro-based industries. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
44. Phytochemical Profiling and in-vivo assessment of Toxicity of Persea americana Seeds and Calotropis procera Roots in Rats.
- Author
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Usman, Yusuf Ado, Alhassan, Aj, Dhanjal, Daljeet Singh, Chopra, Chirag, and Singh, Reena
- Subjects
- *
CALOTROPIS procera , *SEEDS , *AVOCADO , *RATS , *SAPONINS , *TANNINS - Abstract
The phytochemical content and toxicity (mg/kg) of aqueous extracts of Calotropis procera and Persea americana,were evaluated. The roots of C. procera and seeds of P. americana were powdered and percolated in water for 24 hours for aqueous extract. The toxicity was evaluated in two phases (I and II) according to Lorke's method. Twenty-six Wistar rats were divided into two supergroups for two plants. For each extract thirteen rats were divided into, nine rats for phase I and the remaining four for phase II tests. In phase I, nine rats were placed into three groups, each of three ratsandadministered with 10,100, and 1000mg/kg of the extract. In phase II, the remaining four rats were each administered with 2000, 4000, 8000, and 16000mg/kg of the extract respectively. Results showed that the plant samples after a maximum equivalent dose of 16000mg/kg were relatively harmless. Phytochemical analysis of the aqueous seed and root extract showed the presence of flavonoids, cardiac glycoside and absence of tannins, alkaloids and saponins in Calotropis procera while resin was absent in both extracts. In conclusion the aqueous seed of P. americana and root of C. procera may be relatively safe and the acclaimed medicinal property associated with these plants may be due to the presence of this particular phytochemical. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
45. Eye Injuries and Visor Use in the National Football League.
- Author
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Dhoot, Arjan S., Koziarz, Alex, Lee, Yerin, Chopra, Chirag, and Micieli, Jonathan A.
- Subjects
- *
OCULAR injuries , *FOOTBALL , *PROTECTIVE eyeglasses , *EYE protection - Published
- 2021
- Full Text
- View/download PDF
46. Advances in Genetic Reprogramming: Prospects from Developmental Biology to Regenerative Medicine.
- Author
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Dhanjal DS, Singh R, Sharma V, Nepovimova E, Adam V, Kuca K, and Chopra C
- Subjects
- Humans, Animals, Developmental Biology, Genetic Engineering, Tissue Engineering, Induced Pluripotent Stem Cells metabolism, Induced Pluripotent Stem Cells cytology, Regenerative Medicine, Cellular Reprogramming
- Abstract
The foundations of cell reprogramming were laid by Yamanaka and co-workers, who showed that somatic cells can be reprogrammed into pluripotent cells (induced pluripotency). Since this discovery, the field of regenerative medicine has seen advancements. For example, because they can differentiate into multiple cell types, pluripotent stem cells are considered vital components in regenerative medicine aimed at the functional restoration of damaged tissue. Despite years of research, both replacement and restoration of failed organs/ tissues have remained elusive scientific feats. However, with the inception of cell engineering and nuclear reprogramming, useful solutions have been identified to counter the need for compatible and sustainable organs. By combining the science underlying genetic engineering and nuclear reprogramming with regenerative medicine, scientists have engineered cells to make gene and stem cell therapies applicable and effective. These approaches have enabled the targeting of various pathways to reprogramme cells, i.e., make them behave in beneficial ways in a patient-specific manner. Technological advancements have clearly supported the concept and realization of regenerative medicine. Genetic engineering is used for tissue engineering and nuclear reprogramming and has led to advances in regenerative medicine. Targeted therapies and replacement of traumatized , damaged, or aged organs can be realized through genetic engineering. Furthermore, the success of these therapies has been validated through thousands of clinical trials. Scientists are currently evaluating induced tissue-specific stem cells (iTSCs), which may lead to tumour-free applications of pluripotency induction. In this review, we present state-of-the-art genetic engineering that has been used in regenerative medicine. We also focus on ways that genetic engineering and nuclear reprogramming have transformed regenerative medicine and have become unique therapeutic niches., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
- Published
- 2024
- Full Text
- View/download PDF
47. Targeted Inhibition of the PI3K/Akt/mTOR Signaling Axis: Potential for Sarcoma Therapy.
- Author
-
Wani AK, Singh R, Akhtar N, Prakash A, Nepovimova E, Oleksak P, Chrienova Z, Alomar S, Chopra C, and Kuca K
- Subjects
- Humans, Phosphoinositide-3 Kinase Inhibitors pharmacology, Phosphoinositide-3 Kinase Inhibitors therapeutic use, Animals, MTOR Inhibitors pharmacology, MTOR Inhibitors therapeutic use, Protein Kinase Inhibitors pharmacology, Protein Kinase Inhibitors chemistry, Protein Kinase Inhibitors therapeutic use, TOR Serine-Threonine Kinases antagonists & inhibitors, TOR Serine-Threonine Kinases metabolism, Sarcoma drug therapy, Sarcoma metabolism, Sarcoma pathology, Signal Transduction drug effects, Proto-Oncogene Proteins c-akt metabolism, Proto-Oncogene Proteins c-akt antagonists & inhibitors, Phosphatidylinositol 3-Kinases metabolism, Antineoplastic Agents pharmacology, Antineoplastic Agents chemistry, Antineoplastic Agents therapeutic use
- Abstract
Sarcoma is a heterogeneous group of malignancies often resistant to conventional chemotherapy and radiation therapy. The phosphatidylinositol-3-kinase/ protein kinase B /mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway has emerged as a critical cancer target due to its central role in regulating key cellular processes such as cell growth, proliferation, survival, and metabolism. Dysregulation of this pathway has been implicated in the development and progression of bone sarcomas (BS) and soft tissue sarcomas (STS). PI3K/Akt/mTOR inhibitors have shown promising preclinical and clinical activity in various cancers. These agents can inhibit the activation of PI3K, Akt, and mTOR, thereby reducing the downstream signaling events that promote tumor growth and survival. In addition, PI3K/Akt/mTOR inhibitors have been shown to enhance the efficacy of other anticancer therapies, such as chemotherapy and radiation therapy. The different types of PI3K/Akt/mTOR inhibitors vary in their specificity, potency, and side effect profiles and may be effective depending on the specific sarcoma type and stage. The molecular targeting of PI3K/Akt/mToR pathway using drugs, phytochemicals, nanomaterials (NMs), and microbe-derived molecules as Pan-PI3K inhibitors, selective PI3K inhibitors, and dual PI3K/mTOR inhibitors have been delineated. While there are still challenges to be addressed, the preclinical and clinical evidence suggests that these inhibitors may significantly improve patient outcomes. Further research is needed to understand the potential of these inhibitors as sarcoma therapeutics and to continue developing more selective and effective agents to meet the clinical needs of sarcoma patients., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
- Published
- 2024
- Full Text
- View/download PDF
48. Advances in the concept of functional foods and feeds: applications of cinnamon and turmeric as functional enrichment ingredients.
- Author
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Kumar H, Dhalaria R, Guleria S, Sharma R, Cimler R, Dhanjal DS, Chopra C, Kumar V, Manickam S, Siddiqui SA, Kaur T, Verma N, Kumar Pathera A, and Kuča K
- Abstract
Spices are a rich source of vitamins, polyphenols, proteins, dietary fiber, and minerals such as calcium, magnesium, iron, and zinc, all of which play an important role in biological functions. Since ancient times, spices have been used in our kitchen as a food coloring agent. Spices like cinnamon and turmeric allegedly contain various functional ingredients, such as phenolic and volatile compounds. Therefore, this review aims to summarize the current knowledge about the nutritional profiles of cinnamon and turmeric, as well as to analyze the clinical studies on their extracts and essential oils in animals and humans. Furthermore, their enrichment applications for food products and animal feed have also been investigated in terms of safety and toxicity. Numerous studies have shown that cinnamon and turmeric have various health benefits, including the reduction of insulin resistance and insulin signaling pathways in diabetic patients, the reduction of inflammatory biomarkers, and the maintenance of gut microflora in both animals and humans. The food and animal feed industries have taken notice of these health benefits and have begun to promote cinnamon and turmeric as healthy foods. This has resulted in the development of new food products and animal feeds that contain cinnamon and turmeric as primary ingredients, which have been deemed an effective means of promoting cinnamon and turmeric's health benefits.
- Published
- 2023
- Full Text
- View/download PDF
49. Raloxifene, a SERM targets PD-L1: an in-silico study.
- Author
-
Chopra C, Yodun T, Singh H, Singh B, Singh SK, and Goutam U
- Abstract
Objectives: Immunotherapeutic interventions in cancer have been considerably successful and widely accepted for cancer treatment, but are costly and cannot be afforded by all patients. Because of the high cost, the pharmaceutical research groups across the world are sufficiently motivated to discover or design small molecule inhibitors to treat cancer through inhibition of the immune checkpoint proteins previously targeted with monoclonal antibodies. The presented study was designed with an aim to establish raloxifene, a selective estrogen receptor modulator (SERM) as a potential ligand of the immune checkpoint protein Programmed death ligand-1 (PD-L1)., Methods: In the presented study, the in-silico approach was used for identifying a lead molecule against PD-L1. The hits were screened using the similarity-search method, and drug-likeliness analysis, and the leads were identified through ligand-docking using Autodock. In-vitro cytotoxicity analysis was carried out using the standard sulphorhodamine B (SRB) assay and the wound healing analysis to show the inhibition of cellular migration was performed using the standard scratch assay., Results: The in-silico study revealed that raloxifene showed a high drug likelihood and higher binding affinity with PD-L1 as compared to the positive control ( BMS-1166 ; BMS is Bristol Myers Squibb). The binding of raloxifene was shown to occur in the same region as the FDA-approved monoclonal antibodies atezolizumab and durvalumab, indicating the potential of raloxifene for PD1/PD-L1 blockade. In the in-vitro studies, raloxifene showed a time-dependent reduction in IC
50 values for the cell line HCT116 (colon cancer). The scratch assay also revealed that raloxifene significantly reduced the migratory potential of HCT-116 cells in-vitro., Conclusions: PD-L1 is a potential target of the SERM raloxifene in-silico. Overall, this study is one step further towards immune checkpoint blockade using small-molecule inhibitors., Competing Interests: None., (AJTR Copyright © 2023.)- Published
- 2023
50. Antibiotics and Antibiotic Resistance- Flipsides of the Same Coin.
- Author
-
Bhardwaj S, Mehra P, Dhanjal DS, Sharma P, Sharma V, Singh R, Nepovimova E, Chopra C, and Kuča K
- Subjects
- Drug Resistance, Microbial, Humans, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents therapeutic use
- Abstract
One of the major global health care crises in the 21st century is antibiotic resistance. Almost all clinically used antibiotics have resistance emerging to them. Antibiotic Resistance can be regarded as the 'Faceless Pandemic' that has enthralled the entire world. It has become peremptory to develop treatment options as an alternative to antibiotic therapy for combating antibiotic-resistant pathogens. A clearer understanding of antibiotic resistance is required to prevent the rapid spread of antibiotic-resistant genes and the re-emergence of infections. The present review provides an insight into the different classifications and modes of action of antibiotics to understand how the hosts develop resistance to them. In addition, the association of genetics in the development of antibiotic resistance and environmental factors has also been discussed, emphasizing developing action plans to counter this "quiescent pandemic". It is also pertinent to create models that can predict the early resistance so that treatment strategies may build up in advance with the evolving resistance., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
- Published
- 2022
- Full Text
- View/download PDF
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