170 results on '"Che, Jinxin"'
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2. Discovery of a potent CDKs/FLT3 PROTAC with enhanced differentiation and proliferation inhibition for AML
3. Discovery of orally bioavailable phenyltetrazolium derivatives for the acute treatment and the secondary prevention of ischemic stroke
4. Unveiling the protective role of sevoflurane in video-assisted thoracoscopic surgery associated-acute lung injury: Inhibition of ferroptosis
5. A Microenvironment-responsive small-molecule probe and application in quick acute myocardial infarction imaging
6. Integration of covalent organic frameworks and molecularly imprinted polymers for selective extraction of flavonoid naringenin from grapefruit (Citrus × paradisi Macf.) peels
7. Discovery of novel, potent, selective and orally bioavailable HPK1 inhibitor for enhancing the efficacy of anti-PD-L1 antibody
8. Recent progress and applications of small molecule inhibitors of Keap1–Nrf2 axis for neurodegenerative diseases
9. Discovery of a potent and selective PARP1 degrader promoting cell cycle arrest via intercepting CDC25C-CDK1 axis for treating triple-negative breast cancer
10. Structure-based identification of new orally bioavailable BRD9-PROTACs for treating acute myelocytic leukemia
11. Targeted delivery of cathepsin-activatable near-infrared fluorescence probe for ultrahigh specific imaging of peritoneal metastasis
12. Advances of targeting the YAP/TAZ-TEAD complex in the hippo pathway for the treatment of cancers
13. Discovery of new macrophage M2 polarization modulators as multiple sclerosis treatment agents that enable the inflammation microenvironment remodeling
14. Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation
15. Altered pathways and targeted therapy in double hit lymphoma
16. Nitrogen and sulfur co-doped carbon dots derived from granatums and ammonium persulfate to detect tetracyclines in milk
17. Log P analyzation-based discovery of GSH activated biotin-tagged fluorescence probe for selective colorectal cancer imaging
18. Structure-based rational design enables efficient discovery of a new selective and potent AKT PROTAC degrader
19. Design, synthesis and biological evaluation of new dihydropyridine derivatives as PD-L1 degraders for enhancing antitumor immunity
20. Molecular dynamics insights into the selectivity toward CXCR1 and CXCR2 antagonists
21. Design, synthesis and biological evaluation of sulfonamides inhibitors of XPO1 displaying activity against multiple myeloma cells
22. Design, synthesis, and biological evaluation of quinazoline derivatives with covalent reversible warheads as potential FGFR4 inhibitors
23. Discovery of seneciobipyrrolidine derivatives for the amelioration of glucose homeostasis disorders through 4E-BP1/Akt/AMPK signaling activation
24. Fabrication of γ-cyclodextrin-Based metal-organic frameworks as a carrier of cinnamaldehyde and its application in fresh-cut cantaloupes
25. Discovery of New Phenyltetrazolium Derivatives as Ferroptosis Inhibitors for Treating Ischemic Stroke: An Example Development from Free Radical Scavengers.
26. Discovery of a Highly Potent and Selective BRD9 PROTAC Degrader Based on E3 Binder Investigation for the Treatment of Hematological Tumors.
27. Design, synthesis and biological evaluation of quinazoline derivatives as potent and selective FGFR4 inhibitors
28. Discovery of phenyl-linked symmetric small molecules as inhibitors of the programmed cell death-1/programmed cell death-ligand 1 interaction
29. Inhibiting ferroptosis: A novel approach for stroke therapeutics
30. Development of differentiation modulators and targeted agents for treating neuroblastoma
31. Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells
32. Rational Identification of Novel Antibody‐Drug Conjugate with High Bystander Killing Effect against Heterogeneous Tumors.
33. Targeting CXCR1/2: The medicinal potential as cancer immunotherapy agents, antagonists research highlights and challenges ahead
34. Discovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors
35. Discovery of novel indoleaminopyrimidine NIK inhibitors based on molecular docking-based support vector regression (SVR) model
36. Discovery of N‑(1-(6-Oxo-1,6-dihydropyrimidine)-pyrazole) Acetamide Derivatives as Novel Noncovalent DprE1 Inhibitors against Mycobacterium tuberculosis.
37. ADCdb: the database of antibody–drug conjugates.
38. Genomic sequencing, genome-scale metabolic network reconstruction, and in silico flux analysis of the grape endophytic fungus Alternaria sp. MG1
39. Discovery of Novel Oxazepine Derivatives as Akt/ROCK Inhibitors for Growth Arrest and Differentiation Induction in Neuroblastoma Treatment.
40. TransFoxMol: predicting molecular property with focused attention.
41. Integrating docking scores, interaction profiles and molecular descriptors to improve the accuracy of molecular docking: Toward the discovery of novel Akt1 inhibitors
42. ClusterX: a novel representation learning-based deep clustering framework for accurate visual inspection in virtual screening.
43. AKT inhibitor Hu7691 induces differentiation of neuroblastoma cells.
44. Production of pinoresinol diglucoside, pinoresinol monoglucoside, and pinoresinol by Phomopsis sp. XP-8 using mung bean and its major components
45. Screening of Oxygenated Aromatic Compounds for Potential Antifungal Activity against Geotrichum citri-aurantii through Structure–Activity Relationship Analysis.
46. Structural Feature Analyzation Strategies toward Discovery of Orally Bioavailable PROTACs of Bruton's Tyrosine Kinase for the Treatment of Lymphoma.
47. Identification of Novel Covalent XPO1 Inhibitors Based on a Hybrid Virtual Screening Strategy.
48. Antofine inhibits postharvest green mold due to imazalil‐resistant Penicillium digitatum strain Pdw03 by triggering oxidative burst.
49. Identification of new IDH2R140Q inhibitors by discriminatory analysis‐based molecular docking and biological evaluation.
50. Design, Synthesis and Pharmacokinetic Study of Deuterated Ticagrelor Derivatives.
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