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2. The impact of treatment with avacopan on health-related quality of life in antineutrophil cytoplasmic antibody-associated vasculitis: a post-hoc analysis of data from the ADVOCATE trial

Author

Au Peh, Chen, Chakera, Aron, Cooper, Bruce, Kurtkoti, Jagadeesh, Langguth, Daman, Levidiotis, Vicki, Luxton, Grant, Mount, Peter, Mudge, David, Noble, Euan, Phoon, Richard, Ranganathan, Dwarakanathan, Ritchie, Angus, Ryan, Jessica, Suranyi, Michael, Rosenkranz, Alexander, Lhotta, Karl, Kronbichler, Andreas, Demoulin, Nathalie, Bovy, Christophe, Hellemans, Rachel, Hougardy, Jean-Michel, Sprangers, Ben, Wissing, Karl Martin, Pagnoux, Christian, Barbour, Sean, Brachemi, Soumeya, Cournoyer, Serge, Girard, Louis-Philippe, Laurin, Louis-Philippe, Liang, Patrick, Philibert, David, Walsh, Michael, Tesar, Vladimir, Becvar, Radim, Horak, Pavel, Rychlik, Ivan, Szpirt, Wladimir, Dieperink, Hans, Gregersen, Jon Waarst, Ivarsen, Per, Krarup, Elizabeth, Lyngsoe, Cecilie, Rigothier, Claire, Augusto, Jean-Francois, Belot, Alexandre, Chauveau, Dominique, Cornec, Divi, Jourde-Chiche, Noemie, Ficheux, Maxence, Karras, Alexandre, Klein, Alexandre, Maurier, Francois, Mesbah, Rafik, Moranne, Olivier, Neel, Antoine, Quemeneur, Thomas, Saadoun, David, Terrier, Benjamin, Zaoui, Philippe, Schaier, Matthias, Benck, Urs Tobias, Bergner, Raoul, Busch, Martin, Floege, Juergen, Grundmann, Franziska, Haller, Hermann, Haubitz, Marion, Hellmich, Bernhard, Henes, Joerg Christoph, Hohenstein, Bernd, Hugo, Christian, Iking-Konert, Christof, Arndt, Fabian, Kubacki, T, Kotter, Ina, Lamprecht, Peter, Lindner, Tom, Halbritter, Jan, Mehling, Heidrun, Schönermarck, Ulf, Venhoff, Nils, Vielhauer, Volker, Witzke, Oliver, Szombati, Istvan, Szucs, Gabriella, Garibotto, Giacomo, Alberici, Federico, Brunetta, Enrico, Dagna, Lorenzo, De Vita, Salvatore, Emmi, Giacomo, Gabrielli, Armando, Manenti, Lucio, Pieruzzi, Federico, Roccatello, Dario, Salvarani, Carlo, Harigai, Masayoshi, Dobashi, Hiroaki, Atsumi, Tatsuya, Fujimoto, Shoichi, Hagino, Noboru, Ihata, Atsushi, Kaname, Shinya, Kaneko, Yuko, Katagiri, Akira, Katayama, Masao, Kirino, Yohei, Kitagawa, Kiyoki, Komatsuda, Atsushi, Kono, Hajime, Kurasawa, Takahiko, Matsumura, Ryutaro, Mimura, Toshihide, Morinobu, Akio, Murakawa, Yohko, Naniwa, Taio, Nanki, Toshihiro, Ogawa, Noriyoshi, Oshima, Hisaji, Sada, Kenei, Sugiyama, Eiji, Takeuchi, Tohru, Taki, Hirofumi, Tamura, Naoto, Tsukamoto, Tatsuo, Yamagata, Kunihiro, Yamamura, Masahiro, van Daele, Paulus Leon Arthur, Rutgers, Abraham, Teng, Y.K. Onno, Walker, Robert, Chua, Ignatius, Collins, Michael, Rabindranath, Kannaiyan, de Zoysa, Janak, Svensson, My Hanna Sofia, Grevbo, Bard-Waldum, Kalstad, Synove, Little, Mark, Clarkson, Michael, Molloy, Eamonn, Agraz Pamplona, Irene, Anton, Jordi, Barrio Lucia, Vicente, Ciggaran, Secundino, Cinta Cid, Maria, Diaz Encarnacion, Montserrat, Fulladosa Oliveras, Xavier, Jose Soler, Maria, Marco Rusinol, Helena, Praga, Manuel, Quintana Porras, Luis, Segarra, Alfons, Bruchfeld, Annette, Segelmark, Marten, Soveri, Inga, Thomaidi, Eleni, Westman, Kerstin, Neumann, Thomas, Burnier, Michel, Daikeler, Thomas, Dudler, Jean, Hauser, Thomas, Seeger, Harald, Vogt, Bruno, Burton, James, Al Jayyousi, Reem, Amin, Tania, Andrews, Jacqueline, Baines, Laura Anne, Brogan, Paul, Dasgupta, Bhaskar, Doulton, Timothy William Ronald, Flossmann, Oliver, Griffin, Sian V., Harper, Janice Marian, Harper, Lorraine, Kidder, Dana, Klocke, Rainer, Lanyon, Peter Charles, Luqmani, Raashid, McLaren, John Stuart, Makanjuola, David Osagie, McCann, Liza, Nandagudi, Anupama C., Selvan, Shilpa, O'Riordan, Edmond, Patel, Mumtaz, Patel, Rajan Kantilal, Pusey, Charles Dickson, Rajakariar, Ravindra, Robson, Joanna C., Robson, Michael, Salama, Alan David, Smyth, Lucy, Sznajd, Jan, Taylor, Joanne, Sreih, Antonie G., Belilos, Elise, Bomback, Andrew S., Carlin, Jeffrey, Chang Chen Lin, Yih, Derebail, Vimal K., Dragoi, Serban, Dua, Anisha, Forbess, Lindsy, Geetha, Duvuru, Gipson, Patrick, Gohh, Reginald, Greenwood, Gregory Todd, Hugenberg, Steven T., Jimenez, Richard A.H., Kaskas, Marwan Omar, Kermani, Tanaz, Kivitz, Alan J., Koening, Curry, Langford, Carol A., Marder, Galina, Mohamed, Amr Ahmed El-Huesseini, Monach, Paul, Neyra, Nilda Roxana, Niemer, Gregory W., Niles, John, Obi, Reginald, Owens, Charles, Parks, Deborah L., Podoll, Amber S., Rovin, Brad, Sam, R, Shergy, William Julius, Silva, Arnold Lawrence, Specks, Ulrich, Spiera, Robert, Springer, Jason M., Striebich, Christopher Charles, Swarup, Areena, Thakar, Surabhi, Tiliakos, Athan N., Tsai, Yong, Waguespack, Dia R., Chester Wasko, Mary, Strand, Vibeke, Jayne, David R W, Horomanski, Audra, Yue, Huibin, Bekker, Pirow, and Merkel, Peter A

Published
2023
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3. Editorial: Immune Monitoring Responses in Renal Autoimmune Diseases

Author

Teng, Y. K. Onno, Pusey, Charles Dickson, Vaglio, Augusto, Mok, Chi Chui, and van Kooten, Cees

Subjects
ANCA - associated vasculitis, Editorial, Monitoring, Immunologic, membranoproliferative glomerulonephritis (MPGN), Immunology, renal autoimmune diseases, Glomerulonefritis, Humans, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, Lupus Nephritis, Glomerulonephritis, Membranous
Published
2021

5. Experiments in Pharmaceutical Chemistry

Author

Charles Dickson and Charles Dickson

Subjects
Pharmaceutical chemistry--Laboratory manuals, Biochemistry--Laboratory manuals
Abstract

Written by an author with more than 40 years of teaching experience in the field, Experiments in Pharmaceutical Chemistry, Second Edition responds to a critical classroom need for material on directed laboratory investigations in biological and pharmaceutical chemistry. This new edition supplies 75 experiments, expanding the range of topics to 22 m

Published
2014

6. Prevention of Colds

Author

Charles Dickson

Subjects
medicine.medical_specialty, business.industry, Family medicine, Correspondence, General Engineering, medicine, General Earth and Planetary Sciences, General Medicine, business, Data science, General Environmental Science
Published
1954

7. Ischaemia reperfusion injury in islet and pancreas transplantation

Author

Sandhu, Bynvant, Papalois, Vassilios, and Pusey, Charles Dickson

Abstract

The global prevalence of diabetes continues to rise, leading to an obvious need for effective treatment strategies. Whole organ pancreas or isolated islet transplantation is currently offered to a small proportion of the diabetic population, based upon selective indications and fitness for the procedure. The use of both treatment modalities is in part limited due to the potential complications associated with transplantation and imperfect long-term outcomes. Ischaemia reperfusion injury affects both islet and pancreas transplantation and impacts upon the effectiveness and longevity of the graft. Activation of the coagulation cascade has been described as a common mediator of ischaemia reperfusion injury, in both islet and pancreas transplantation. Cytotopic anticoagulant peptides have been proposed as a treatment strategy in other solid organ transplants as an alternative to systemic anticoagulation. This approach offers a cell-binding therapy, reducing coagulation-associated injury whilst avoiding bleeding risks associated with systemic anticoagulation. The aims of my project were to examine the efficacy of cytotopic anticoagulation in the context of islet and pancreas transplantation and to design a model for examination of reperfusion injury in the human pancreas. I have explored the expression of Tissue Factor in donor pancreas grafts and shown an upregulation of TF expression in isolated human islets exposed to hypoxic, ischaemic conditions. Using a specialised coagulation assay I have confirmed the efficacy of the cytotopic anticoagulant in reducing Tissue Factor initiated coagulation. I have shown an improvement in endothelial viability and function using cytotopic anticoagulation in in vitro models of ischaemia reperfusion. My project also investigated the use of cytotopic anticoagulation in human islet reperfusion models. I demonstrated a reduction in the expression of Tissue Factor and activation of the coagulation cascade in islets treated with the cytotopic anticoagulation, I also explored the impact upon activation of associated mechanisms of injury in islet reperfusion. Finally, I have successfully developed a new model of ex vivo organ reperfusion for the examination of ischaemia reperfusion injury in the pancreas and other organs in the future.

Published
2020
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8. Th17-Immune Response in Patients With Membranous Nephropathy Is Associated With Thrombosis and Relapses

Author

Cremoni, Marion, Brglez, Vesna, Perez, Sandra, Decoupigny, Fabrice, Zorzi, Kévin, Andreani, Marine, Gérard, Alexandre, Boyer-Suavet, Sonia, Ruetsch, Caroline, Benzaken, Sylvia, Esnault, Vincent, Seitz-Polski, Barbara, Service de Néphrologie-Dialyse-Transplantation, CHU de Nice, Université Côte d'Azur, France, Unité de Recherche Clinique de la Côte d’Azur [Nice] (URRIS UR2CA), Université Côte d'Azur (UCA), Centre de Référence Maladies Rares Syndrome Néphrotique Idiopathique, CHU de Nice, Études des Structures, des Processus d’Adaptation et des Changements de l’Espace (ESPACE), Université Côte d'Azur (UCA)-Avignon Université (AU)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Laboratoire d’Immunologie [CHU Nice], Centre Hospitalier Universitaire de Nice (CHU Nice)-Université Côte d'Azur (UCA), Frontiers in Immunology, Y. K. O. Teng, Charles Dickson Pusey, Augusto Vaglio, Cees Van Kooten and Chi Chiu Mok, Unité de Recherche Clinique de la Côte d’Azur (URRIS UR2CA), Université Nice Sophia Antipolis (1965 - 2019) (UNS), and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Avignon Université (AU)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)

Subjects
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Exciting times for the field of renal autoimmune diseases have begun. In 2021, for the first time, two new drugs belimumab (1) and voclosporin ( 2) are approved for the treatment of lupus nephritis (LN) (1, 2). Other novel targeted therapies demonstrate clinical efficacy in large, randomized trials, such as avacopan for ANCA-associated vasculitis (AAV) (3), imlifidase for Goodpasture’s disease and iptacopan for IgA nephropathy (IgAN). Pathogenic molecules are specifically targeted by new drugs that help to uncover novel aspects of disease mechanisms leading to glomerulonephritis. Simultaneously, the field is boosted by novel big data technologies on the single cell levels such as high-sensitive multi-color flow cytometry, single-cell genomics (single-cell RNA sequencing - scRNAseq), single cell metabolomics and proteomics. The novel treatment options in renal autoimmune diseases almost simultaneously require new immunomonitoring tools. ‘Immunomonitoring’includes the wide range of approaches to monitoring immune responses by the cellular immune system (e.g. T-cells, B-cells, plasma cells, dendritic cells, neutrophils etc.), or by the humoral immune system (e.g. cytokines, (auto-)antibodies, urinary markers, etc.). Monitoring relevant immune responses in patients with renal autoimmune diseases helps us to better understand a) the underpinning immunological pathophysiology of these diseases; b) the beneficial effects of novel treatments on autoimmunity; and c) can potentially help doctors and patients guide a personalized treatment strategy, adding information on immunological (non-)response to a clinical (non-) response treatment and on disease prognosis. In the present Research Topic, we have been able to collect for you a vast amount of research addressing novel ways and the roleof immunomonitoring in the broad range of renal autoimmune disease including LN, AAV, IgAN, idiopathic membranous nephropathy (iMN) and complement-mediated disease (CMD).

Published
2021

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