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1. A highly efficient transgene knock-in technology in clinically relevant cell types

Author

Allen, Alexander G., Khan, Samia Q., Margulies, Carrie M., Viswanathan, Ramya, Lele, Swarali, Blaha, Laura, Scott, Sean N., Izzo, Kaitlyn M., Gerew, Alexandra, Pattali, Rithu, Cochran, Nadire R., Holland, Carl S., Zhao, Amy H., Sherman, Stephen E., Jaskolka, Michael C., Wu, Meng, Wilson, Aaron C., Sun, Xiaoqi, Ciulla, Dawn M., Zhang, Deric, Nelson, Jacqueline D., Zhang, Peisheng, Mazzucato, Patrizia, Huang, Yan, Giannoukos, Georgia, Marco, Eugenio, Nehil, Michael, Follit, John A., Chang, Kai-Hsin, Shearman, Mark S., Wilson, Christopher J., and Zuris, John A.

Published
2024
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5. Light Induced Proton Coupled Charge Transfer Triggers Counterion Directional Translocation.

Author

Chang, Kai‐Hsin, Yang, Yu‐Hsuan, Su, Kuan‐Hsuan, Chen, Yi, Lin, Ta‐Chun, Li, Jian‐Liang, Liu, Zong‐Ying, Shi, Jing‐Han, Wang, Tzu‐Fang, Chang, Yi‐Tyng, Demchenko, Alexander P., Yang, Hsiao‐Ching, and Chou, Pi‐Tai

Subjects
*PROTONS, *TIME-resolved spectroscopy, *POLAR vortex, *FLUORESCENCE spectroscopy, *COMPUTER simulation, *CHARGE transfer
Abstract

We demonstrate directed translocation of ClO4− anions from cationic to neutral binding site along the synthetized BPym‐OH dye molecule that exhibits coupled excited‐state intramolecular proton‐transfer (ESIPT) and charge‐transfer (CT) reaction (PCCT). The results of steady‐state and time‐resolved spectroscopy together with computer simulation and modeling show that in low polar toluene the excited‐state redistribution of electronic charge enhanced by ESIPT generates the driving force, which is much stronger than by CT reaction itself and provides more informative gigantic shifts of fluorescence spectra signaling on ultrafast ion motion. The associated with ion translocation red‐shifted fluorescence band (at 750 nm, extending to near‐IR region) appears at the time ~83 ps as a result of electrochromic modulation of PCCT reaction. It occurs at substantial delay to PCCT that displayed fluorescence band at 640 nm and risetime of <200 fs. Thus, it becomes possible to visualize the manifestations of light‐triggered ion translocation and of its driving force by fluorescence techniques and to separate them in time and energy domains. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Long-Term Engraftment and Fetal Globin Induction upon BCL11A Gene Editing in Bone-Marrow-Derived CD34+ Hematopoietic Stem and Progenitor Cells

Author

Chang, Kai-Hsin, Smith, Sarah E., Sullivan, Timothy, Chen, Kai, Zhou, Qianhe, West, Jason A., Liu, Mei, Liu, Yingchun, Vieira, Benjamin F., Sun, Chao, Hong, Vu P., Zhang, Mingxuan, Yang, Xiao, Reik, Andreas, Urnov, Fyodor D., Rebar, Edward J., Holmes, Michael C., Danos, Olivier, Jiang, Haiyan, and Tan, Siyuan

Published
2017
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10. Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution

Author

Vierstra, Jeff, Rynes, Eric, Sandstrom, Richard, Zhang, Miaohua, Canfield, Theresa, Hansen, R. Scott, Stehling-Sun, Sandra, Sabo, Peter J., Byron, Rachel, Humbert, Richard, Thurman, Robert E., Johnson, Audra K., Vong, Shinny, Lee, Kristen, Bates, Daniel, Neri, Fidencio, Diegel, Morgan, Giste, Erika, Haugen, Eric, Dunn, Douglas, Wilken, Matthew S., Josefowicz, Steven, Samstein, Robert, Chang, Kai-Hsin, Eichler, Evan E., De Bruijn, Marella, Reh, Thomas A., Skoultchi, Arthur, Rudensky, Alexander, Orkin, Stuart H., Papayannopoulou, Thalia, Treuting, Piper M., Selleri, Licia, Kaul, Rajinder, Groudine, Mark, Bender, M. A., and Stamatoyannopoulos, John A.

Published
2014

15. A comparative encyclopedia of DNA elements in the mouse genome

Author

Yue, Feng, Cheng, Yong, Breschi, Alessandra, Vierstra, Jeff, Wu, Weisheng, Ryba, Tyrone, Sandstrom, Richard, Ma, Zhihai, Davis, Carrie, Pope, Benjamin D., Shen, Yin, Pervouchine, Dmitri D., Djebali, Sarah, Thurman, Robert E., Kaul, Rajinder, Rynes, Eric, Kirilusha, Anthony, Marinov, Georgi K., Williams, Brian A., Trout, Diane, Amrhein, Henry, Fisher-Aylor, Katherine, Antoshechkin, Igor, DeSalvo, Gilberto, See, Lei-Hoon, Fastuca, Meagan, Drenkow, Jorg, Zaleski, Chris, Dobin, Alex, Prieto, Pablo, Lagarde, Julien, Bussotti, Giovanni, Tanzer, Andrea, Denas, Olgert, Li, Kanwei, Bender, M. A., Zhang, Miaohua, Byron, Rachel, Groudine, Mark T., McCleary, David, Pham, Long, Ye, Zhen, Kuan, Samantha, Edsall, Lee, Wu, Yi-Chieh, Rasmussen, Matthew D., Bansal, Mukul S., Kellis, Manolis, Keller, Cheryl A., Morrissey, Christapher S., Mishra, Tejaswini, Jain, Deepti, Dogan, Nergiz, Harris, Robert S., Cayting, Philip, Kawli, Trupti, Boyle, Alan P., Euskirchen, Ghia, Kundaje, Anshul, Lin, Shin, Lin, Yiing, Jansen, Camden, Malladi, Venkat S., Cline, Melissa S., Erickson, Drew T., Kirkup, Vanessa M., Learned, Katrina, Sloan, Cricket A., Rosenbloom, Kate R., Lacerda de Sousa, Beatriz, Beal, Kathryn, Pignatelli, Miguel, Flicek, Paul, Lian, Jin, Kahveci, Tamer, Lee, Dongwon, James Kent, W., Ramalho Santos, Miguel, Herrero, Javier, Notredame, Cedric, Johnson, Audra, Vong, Shinny, Lee, Kristen, Bates, Daniel, Neri, Fidencio, Diegel, Morgan, Canfield, Theresa, Sabo, Peter J., Wilken, Matthew S., Reh, Thomas A., Giste, Erika, Shafer, Anthony, Kutyavin, Tanya, Haugen, Eric, Dunn, Douglas, Reynolds, Alex P., Neph, Shane, Humbert, Richard, Scott Hansen, R., De Bruijn, Marella, Selleri, Licia, Rudensky, Alexander, Josefowicz, Steven, Samstein, Robert, Eichler, Evan E., Orkin, Stuart H., Levasseur, Dana, Papayannopoulou, Thalia, Chang, Kai-Hsin, Skoultchi, Arthur, Gosh, Srikanta, Disteche, Christine, Treuting, Piper, Wang, Yanli, Weiss, Mitchell J., Blobel, Gerd A., Cao, Xiaoyi, Zhong, Sheng, Wang, Ting, Good, Peter J., Lowdon, Rebecca F., Adams, Leslie B., Zhou, Xiao-Qiao, Pazin, Michael J., Feingold, Elise A., Wold, Barbara, Taylor, James, Mortazavi, Ali, Weissman, Sherman M., Stamatoyannopoulos, John A., Snyder, Michael P., Guigo, Roderic, Gingeras, Thomas R., Gilbert, David M., Hardison, Ross C., Beer, Michael A., and Ren, Bing

Subjects
Man -- Genetic aspects, Genetic research, Human beings -- Genetic aspects, Genomes -- Comparative analysis, Mice -- Genetic aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The laboratory mouse shares the majority of its protein-coding genes with humans, making it the premier model organism in biomedical research, yet the two mammals differ in significant ways. To gain greater insights into both shared and species-specific transcriptional and cellular regulatory programs in the mouse, the Mouse ENCODE Consortium has mapped transcription, DNase I hypersensitivity, transcription factor binding, chromatin modifications and replication domains throughout the mouse genome in diverse cell and tissue types. By comparing with the human genome, we not only confirm substantial conservation in the newly annotated potential functional sequences, but also find a large degree of divergence of sequences involved in transcriptional regulation, chromatin state and higher order chromatin organization. Our results illuminate the wide range of evolutionary forces acting on genes and their regulatory regions, and provide a general resource for research into mammalian biology and mechanisms of human diseases., Author(s): Feng Yue [1, 2]; Yong Cheng [3]; Alessandra Breschi [4]; Jeff Vierstra [5]; Weisheng Wu [6]; Tyrone Ryba [7]; Richard Sandstrom [5]; Zhihai Ma [3]; Carrie Davis [8]; Benjamin [...]

Published
2014
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16. AsCas12a Gene Editing of HBG1/2 Promoters with Edit-301 Results in Early and Sustained Normalization of Hemoglobin and Increased Fetal Hemoglobin in Patients with Severe Sickle Cell Disease and Transfusion-Dependent Beta-Thalassemia

Author

Frangoul, Haydar, Hanna, Rabi, McKinney, Christopher, Pineiro, Luis, Mapara, Markus, Dalal, Jignesh, Chang, Kai-Hsin, Jaskolka, Michael, Kim, Keunpyo, Farrington, Daphne L., Wally, Maha, Mei, Baisong, Lawal, Adebayo, Afonja, Olubunmi, and Walters, Mark C.

Published
2024
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20. AsCas12a Gene Editing of HBG1/2 Promoters with EDIT-301 Results in Rapid and Sustained Normalization of Hemoglobin and Increased Fetal Hemoglobin in Patients with Severe Sickle Cell Disease and Transfusion-Dependent Beta-Thalassemia

Author

Hanna, Rabi, Frangoul, Haydar, McKinney, Christopher, Pineiro, Luis, Mapara, Markus, Dalal, Jignesh, Chang, Kai-Hsin, Jaskolka, Michael, Kim, Keunpyo, Farrington, Daphne L., Wally, Maha, Mei, Baisong, Lawal, Adebayo, Afonja, Olubunmi O., and Walters, Mark C.

Published
2023
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22. MOUSE GENOMICS: Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution

Author

Vierstra, Jeff, Rynes, Eric, Sandstrom, Richard, Zhang, Miaohua, Canfield, Theresa, Hansen, Scott R., Stehling-Sun, Sandra, Sabo, Peter J., Byron, Rachel, Humbert, Richard, Thurman, Robert E., Johnson, Audra K., Vong, Shinny, Lee, Kristen, Bates, Daniel, Neri, Fidencio, Diegel, Morgan, Giste, Erika, Haugen, Eric, Dunn, Douglas, Wilken, Matthew S., Josefowicz, Steven, Samstein, Robert, Chang, Kai-Hsin, Eichler, Evan E., De Bruijn, Marella, Reh, Thomas A., Skoultchi, Arthur, Rudensky, Alexander, Orkin, Stuart H., Papayannopoulou, Thalia, Treuting, Piper M., Selleri, Licia, Kaul, Rajinder, Groudine, Mark, Bender, M. A., and Stamatoyannopoulos, John A.

Published
2014
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32. Substituent Effects in Six(Anilido)‐Five(Thiazole) Membered Ring Boron Difluoride Dyes.

Author

Tseng, Sheng‐Ming, Chao, Chi‐Min, Chang, Kai‐Hsin, Wen, Chi‐Sheng, Chou, Tai‐Che, Tsai, Tsung‐Lun, Wu, Ting‐Wen, Haung, Xiao‐Ci, Liu, Jun‐Qi, Hung, Cheng‐Hsien, Liu, Kuan‐Miao, and Chou, Pi‐Tai

Subjects
BORON, BORON trifluoride, FLUORESCENCE yield, DYES & dyeing, FLUORESCENCE
Abstract

A series of new six (anilido)‐five (thiazole) membered ring boron difluoride dyes, namely BFs, have been synthesized from the corresponding para‐ and meta‐substituted 2‐(2'‐methylaminophenyl) benzothiazoles through complexation with boron trifluoride. Depending on the substituent effect, the derivatives can switch the emission properties from fluorescence with 100 % emission yield to slim fluorescence but >90 % triplet state population and peak wavelength tuning from 490 nm to 610 nm. Compared with non‐complexed precursors, the rigid, highly planar structure and significantly red‐shifted absorption and emission for BFs indicate that the boron center facilitates the formation of a bridge leading to increased rigidity, and is also involved in π‐conjugation, increasing the transition dipole and suppressing the non‐radiative internal conversion. Together with optical ∼100 % transparent window around 325–375 nm, BFs may find unique applications, among which the fluorescence up‐conversion via triplet‐triplet annihilation is demonstrated. [ABSTRACT FROM AUTHOR]

Published
2022
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33. Functionalizing Collagen with Vessel‐Penetrating Two‐Photon Phosphorescence Probes: A New In Vivo Strategy to Map Oxygen Concentration in Tumor Microenvironment and Tissue Ischemia.

Author

Wu, Cheng‐Ham, Kisel, Kristina S., Thangavel, Muthu Kumar, Chen, Yi‐Ting, Chang, Kai‐Hsin, Tsai, Ming‐Rung, Chu, Chia‐Yu, Shen, Yu‐Fang, Wu, Pei‐Chun, Zhang, Zhiming, Liu, Tzu‐Ming, Jänis, Janne, Grachova, Elena V., Shakirova, Julia R., Tunik, Sergey P., Koshevoy, Igor O., and Chou, Pi‐Tai

Subjects
TUMOR microenvironment, PHOSPHORESCENCE, OXYGEN detectors, COLLAGEN, ISCHEMIA, EXTRACELLULAR matrix
Abstract

The encapsulation and/or surface modification can stabilize and protect the phosphorescence bio‐probes but impede their intravenous delivery across biological barriers. Here, a new class of biocompatible rhenium (ReI) diimine carbonyl complexes is developed, which can efficaciously permeate normal vessel walls and then functionalize the extravascular collagen matrixes as in situ oxygen sensor. Without protective agents, ReI‐diimine complex already exhibits excellent emission yield (34%, λem = 583 nm) and large two‐photon absorption cross‐sections (σ2 = 300 GM @ 800 nm) in water (pH 7.4). After extravasation, remarkably, the collagen‐bound probes further enhanced their excitation efficiency by increasing the deoxygenated lifetime from 4.0 to 7.5 µs, paving a way to visualize tumor hypoxia and tissue ischemia in vivo. The post‐extravasation functionalization of extracellular matrixes demonstrates a new methodology for biomaterial‐empowered phosphorescence sensing and imaging. [ABSTRACT FROM AUTHOR]

Published
2021
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35. Cyano Derivatives of 7‐Aminoquinoline That Are Highly Emissive in Water: Potential for Sensing Applications.

Author

Chang, Kai‐Hsin, Chao, Wei‐Chih, Yang, Yu‐Hsuan, Wu, Cheng‐Ham, Li, Zhi‐Bin, Chen, Hung‐Che, Chou, Yi‐Te, Annie Ho, Ja‐an, Li, Xin‐Cheng, Peng, Yu‐Chiang, Liao, Yu‐Chan, Liu, Kuan‐Miao, Chao, Chi‐Min, and Chou, Pi‐Tai

Subjects
*FLUORESCENT probes, *FLUORESCENCE, *HYDROGEN sulfide
Abstract

6‐Cyano‐7‐aminoquinoline (6CN−7AQ) and 3‐cyano‐7‐aminoquinoline (3CN−7AQ) were synthesized and found to exhibit intense emission with quantum yield as high as 63 % and 85 %, respectively, in water. Conversely, their derivatives 6‐cyano‐7‐azidoquinoline (6CN−7N3Q) and 3‐cyano‐7‐azidoquinoline (3CN−7N3Q) show virtually no emission, which makes them suitable to be used as recognition agents in azide reactions based on fluorescence recovery. Moreover, conjugation of 6CN−7AQ with a hydrophobic biomembrane‐penetration peptide PFVYLI renders a nearly non‐emissive 6CN−7AQ‐PFVYLI composite, which can be digested by proteinase K, recovering the highly emissive 6CN−7AQ with ∼200‐fold enhancement. The result provides an effective early confirmation for RT‐qPCR in viral detection. [ABSTRACT FROM AUTHOR]

Published
2021
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39. Broadening the Horizon of the Bell–Evans–Polanyi Principle towards Optically Triggered Structure Planarization.

Author

Chen, Yi, Chang, Kai‐Hsin, Meng, Fan‐Yi, Tseng, Sheng‐Ming, and Chou, Pi‐Tai

Subjects
*DOUBLE bonds, *THERMODYNAMICS, *LUMINESCENCE, *DATA structures, *REFORMATION, *TRANSITION state theory (Chemistry)
Abstract

Finding a relationship between kinetics and thermodynamics may be difficult. However, semi‐empirical rules exist to compensate for this shortcoming, among which the Bell–Evans–Polanyi (B‐E‐P) principle is an example for reactions involving bond breakage and reformation. We expand the B‐E‐P principle to a new territory by probing photoinduced structure planarization (PISP) of a series of dibenz[b,f]azepine derivatives incorporating bent‐to‐planar and rotation motion. The latter involves twisting of the partial double bond character, thereby inducing a barrier that is substituent dependent at the para N‐phenyl position. The transition‐state structure and frequency data satisfy and broaden the B‐E‐P principle to PISP reactions without bond rearrangement. Together with dual emissions during PISP, this makes possible harnessing of the kinetics/thermodynamics relationship and hence ratiometric luminescence properties for excited‐state structural transformations. [ABSTRACT FROM AUTHOR]

Published
2021
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41. Delayed Charge Recombination by Open‐Shell Organics: Its Application in Achieving Superb Photodetectors with Broadband (400–1160 nm) Ultrahigh Sensitivity and Stability.

Author

Shen, Shin‐Wei, Chen, Deng‐Gao, Chen, I‐Tung, Chang, Kai‐Hsin, Lee, Chuan‐Wei, Fang, Chia‐Te, Chen, Yi‐Ting, Chuang, Wei‐Tsung, Lee, Yi‐Hsien, Wu, Yao‐Ting, Chou, Pi‐Tai, and Wu, Chih‐I

Subjects
PHOTODETECTORS, OPTOELECTRONIC devices, PHOTOEXCITATION, REACTION time, ABSORPTION coefficients, LIGHT absorption, SINGLET state (Quantum mechanics)
Abstract

Monolayer transition‐metal dichalcogenides have inspired worldwide efforts in optoelectronic devices but real applications are hindered with their reduced optical absorption due to their atomically ultrathin signature. In this study, by utilizing their biradical nature such as excellent absorption coefficient, broad bandwidth from the ultraviolet to near‐infrared region, and small triplet–singlet energy gap, a series of helicene 5,14‐diaryldiindeno[2,1‐f:1′,2′‐j]picene (DDP) derivatives (1ab, 1ac, and 1bb) are integrated with monolayer MoS2 for extraordinary photodetector performance and outstanding stability. Via comprehensive time‐resolved studies, the interfacial charge‐transfer process from the DDPs to the MoS2 layer is evidenced by the stabilized exciton property of the organics (1ac)/MoS2 heterostructure. Significantly, the 1ac/MoS2 photodetector exhibits an ultrahigh photoresponsivity of 5 × 107 A W−1 and a fast response speed of 45 ms due to the highly efficient photoexcited carrier separation and the matched type‐II energy band alignment. The biradical 1ac/MoS2 hybrid photodetector shows no sign of degradation after one‐month operation. The results pave a new avenue for biradical based high‐performance and super‐broadband optoelectronic devices. [ABSTRACT FROM AUTHOR]

Published
2020
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44. Mono‐Heteroatom Substitution for Harnessing Excited‐State Structural Planarization of Dihydrodibenzo[a,c]phenazines.

Author

Chen, Yi, Chen, Deng‐Gao, Chen, Yi‐An, Wu, Cheng‐Ham, Chang, Kai‐Hsin, Meng, Fan‐Yi, Chen, Meng‐Chi, Lin, Jia‐An, Huang, Chun‐Ying, Su, Jianhua, Tian, He, and Chou, Pi‐Tai

Subjects
SELENIUM, STOKES shift, NONBONDING electron pairs, ELECTRON pairs, EXCITED states
Abstract

With the aim of generalizing the structure–properties relationship of bending heterocyclic molecules that undergo prominent photoinduced structural planarization (PISP), a series of new dihydrodibenzo[ac]phenazine derivatives in which one nitrogen atom is replaced by oxygen (PNO), sulfur (PNS), selenium (PNSe), or dimethylmethanediyl (PNC) was strategically designed and synthesized. Compounds PNO, PNS, and PNSe have significantly nonplanar geometries in the ground state, which undergo PISP to give a planarlike conformer and hence a large emission Stokes shift. A combination of femtosecond early relaxation dynamics and computational approaches established an R*→I* (intermediate)→P* sequential kinetic pattern for PNS and PNSe, whereas PNO undergoes R*→P* one‐step kinetics. The polarization ability of the substituted heteroatoms, which is in the order O

Published
2019
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45. Catalytic‐Type Excited‐State N−H Proton‐Transfer Reaction in 7‐Aminoquinoline and Its Derivatives.

Author

Chang, Kai‐Hsin, Liu, Ying‐Hsuan, Liu, Jiun‐Chi, Peng, Yu‐Chiang, Yang, Yu‐Hsuan, Li, Zhi‐Bin, Jheng, Ren‐Hua, Chao, Chi‐Min, Liu, Kuan‐Miao, and Chou, Pi‐Tai

Subjects
*PROTOGENIC solvents, *RESONANCE effect, *CATALYSIS, *BASICITY, *PROTONS
Abstract

7‐Aminoquinoline (7AQ) and various amino derivatives thereof (‐NHR) have been strategically designed and synthesized to study their excited‐state proton‐transfer (ESPT) properties. Due to the large separation between the proton donor ‐NHR and the acceptor ‐N‐ site, ESPT in 7AQ derivatives, if available, should proceed under protic solvent catalysis. ESPT is found to be influenced by the acidity of ‐NHR and the basicity of the proton‐acceptor ‐N‐ in the quinoline moiety. The latter is varied by the resonance effect at the quinoline ‐N‐ site induced by the ‐NHR substituent. For those 7AQ derivatives undergoing ESPT, increased quinoline basicity results in a faster rate of ESPT, implying that proton donation from methanol to the quinoline moiety may serve as a key step in the process. Our studies also indicate the existence of an equilibrium between cis and trans arrangements of ‐NHR in terms of its hydrogen‐bond (H‐bond) configuration with methanol, whereby only the cis‐H‐bonded form undergoes methanol‐assisted ESPT. With one exception, the interconversion between cis and trans configurations is much faster than the rate of ESPT, yielding amino‐type (normal form) and imine‐type (proton‐transfer tautomer) emissions with distinct relaxation dynamics. [ABSTRACT FROM AUTHOR]

Published
2019
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46. Indeno[1,2‐b]fluorene‐Based [2,2]Cyclophanes with 4n/4n and 4n/[4n+2] π Electrons: Syntheses, Structural Analyses, and Excitonic Coupling Properties.

Author

Wang, Chi‐Shin, Wei, Yu‐Chen, Chang, Kai‐Hsin, Chou, Pi‐Tai, and Wu, Yao‐Ting

Subjects
CYCLOPHANES, ABSORPTION spectra, EXCITED states, ELECTRONS, SPECTRUM analysis, X-ray crystallography
Abstract

Indeno[1,2‐b]fluorene‐based [2,2]cyclophanes with 4n/4n and 4n/[4n+2] π‐electron systems were prepared, and their structures were identified by X‐ray crystallography. With short π–π distances around 3.0 Å, [2.2](5,11)indeno[1,2‐b]fluorenophane and its precursor [2.2](5,11)indeno[1,2‐b]fluorene‐6,12‐dionophane exhibit remarkable transannular interactions, leading to their unusual electrochemical and photophysical properties. With the aid of femtosecond transient absorption spectroscopy, the transition from the monomeric excited state to the redshifted H‐type dimeric state was first observed, correlating to the calculated excitonic energy splitting and the steady‐state absorption spectra induced by charge‐transfer‐mediated superexchange interaction. [ABSTRACT FROM AUTHOR]

Published
2019
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47. Diindeno‐Fused Dibenzo[a,h]anthracene and Dibenzo[c,l]chrysene: Syntheses, Structural Analyses, and Properties.

Author

Boominathan, Siva Senthil Kumar, Chang, Kai‐Hsin, Liu, Yu‐Chiao, Wang, Chi‐Shin, Wu, Cheng‐Feng, Chiang, Ming‐Hsi, Chou, Pi‐Tai, and Wu, Yao‐Ting

Subjects
*ANTHRACENE, *LIGHT absorption, *POLYCYCLIC aromatic hydrocarbons, *ISOMERS, *BIRADICALS, *ABSORPTION
Abstract

Diindeno‐fused dibenzo[a,h]anthracene 6 and diindeno‐fused dibenzo[c,l]chrysene 9 contain the key moieties 1,4‐quinodipropene (1,4‐QDP) and 2,6‐naphthoquinodipropene (2,6‐NQDP), respectively, and they both have an open‐shell singlet ground state. The latter compound exhibits a strong biradical character and interesting properties, including a low ΔET−S (2.44 kcal mol−1), a small HOMO–LUMO gap (1.06 eV), a wide photoabsorption range (250–1172 nm), and a large two‐photon absorption cross‐section (σ=1342±56 GM). This work verifies that 6 has a slightly larger HOMO–LUMO gap and ΔET−S than its helical isomer diindeno[2,1‐f:1′,2′‐j]picene (DIP), but is a much stronger two‐photon absorber, verifying the important effect of geometry on the photophysical properties. [ABSTRACT FROM AUTHOR]

Published
2019
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49. Comparative Studies Reveal Robust HbF Induction By Editing of HBG1/2 Promoters or BCL11A Erythroid-Enhancer in Human CD34+ Cells but That BCL11A Erythroid-Enhancer Editing Is Associated with Selective Reduction in Erythroid Lineage Reconstitution in a Xenotransplantation Model

Author

Chang, Kai-Hsin, Sanchez, Minerva, Heath, Jack, deDreuzy, Edouard, Haskett, Scott, Vogelaar, Abigail, Gogi, Kiran, Da Silva, Jen, Wang, Tongyao, Sadowski, Andrew, Gotta, Gregory, Siwak, Jamaica, Viswanathan, Ramya, Loveluck, Katherine, Chao, Hoson, Tillotson, Eric, Chalishazar, Aditi, Dass, Abhishek, Ta, Frederick, Brennan, Emily, Tabbaa, Diana, Marco, Eugenio, Zuris, John A, Reyon, Deepak, Isik, Meltem, Friedland, Ari, Ta, Terence, Harbinski, Fred, Giannoukos, Georgia, Teixeira, Sandra, Wilson, Christopher J, Albright, Charlie, and Jiang, Haiyan

Published
2018
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