1. Born from pre-eclamptic pregnancies predisposes infants to altered cortisol metabolism in the first postnatal year
- Author
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Jason Waugh, Markus G. Mohaupt, Lesia O. Kurlak, Hiten D. Mistry, Chandrima Roy, Rebecca Chikhi, Fiona Broughton Pipkin, and Bernhard Dick
- Subjects
medicine.medical_specialty ,pre-eclampsia ,steroid hormones ,Endocrinology, Diabetes and Metabolism ,610 Medicine & health ,Urine ,030204 cardiovascular system & hematology ,Excretion ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Cortisol metabolism ,Internal medicine ,Internal Medicine ,medicine ,Fetal organ ,030219 obstetrics & reproductive medicine ,infants ,business.industry ,Research ,medicine.disease ,urine ,Metabolic syndrome ,business ,Glucocorticoid ,medicine.drug - Abstract
Pre-eclampsia leads to disturbed fetal organ development, including metabolic syndrome, attributed to altered pituitary-adrenal feedback loop. We measured cortisol metabolites in infants born from pre-eclamptic and normotensive women and hypothesised that glucocorticoid exposure would be exaggerated in the former. Twenty-four hour urine was collected from infants at months 3 and 12. Cortisol metabolites and apparent enzyme activities were analysed by gas chromatography-mass spectrometry. From 3 to 12 months, excretion of THS, THF and pregnandiol had risen in both groups; THF also rose in the pre-eclamptic group. No difference was observed with respect to timing of the visit or to hypertensive status for THE or total F metabolites (P>0.05). All apparent enzymes activities, except 17α-hydroxylase, were lower in infants at 12 compared to 3 months in the normotensive group. In the pre-eclamptic group, only 11β-HSD activities were lower at 12 months.17α-hydroxylase and 11β-HSD activities of tetrahydro metabolites were higher in the pre-eclamptic group at 3 months (P
- Published
- 2015