11 results on '"Cavalcante, Bruno Raphael Ribeiro"'
Search Results
2. Exercise-linked consequences on epilepsy
- Author
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Cavalcante, Bruno Raphael Ribeiro, Improta-Caria, Alex Cleber, Melo, Victor Hugo de, and De Sousa, Ricardo Augusto Leoni
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- 2021
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3. Is there a place for mesenchymal stromal cell-based therapies in the therapeutic armamentarium against COVID-19?
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da Silva, Kátia Nunes, Gobatto, André Luiz Nunes, Costa-Ferro, Zaquer Suzana Munhoz, Cavalcante, Bruno Raphael Ribeiro, Caria, Alex Cleber Improta, de Aragão França, Luciana Souza, Nonaka, Carolina Kymie Vasques, de Macêdo Lima, Fernanda, Lopes-Pacheco, Miquéias, Rocco, Patricia Rieken Macêdo, and de Freitas Souza, Bruno Solano
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- 2021
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4. Arsenic Trioxide Triggers Apoptosis of Metastatic Oral Squamous Cells Carcinoma with Concomitant Downregulation of GLI1 in Hedgehog Signaling.
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Nogueira, Raphael Luís Rocha, de Araújo, Taís Bacelar Sacramento, Valverde, Ludmila Faro, Silva, Viviane Aline Oliveira, Cavalcante, Bruno Raphael Ribeiro, Rossi, Erik Aranha, Allahdadi, Kyan James, dos Reis, Mitermayer Galvão, Pereira, Thiago Almeida, Coletta, Ricardo D., Bezerra, Daniel Pereira, de Freitas Souza, Bruno Solano, Dias, Rosane Borges, and Rocha, Clarissa A. Gurgel
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ARSENIC trioxide ,HEDGEHOG signaling proteins ,SQUAMOUS cell carcinoma ,CELL morphology ,NUCLEAR fragmentation ,APOPTOSIS - Abstract
Given the lack of advances in Oral Squamous Cell Carcinoma (OSCC) therapy in recent years, pharmacological strategies to block OSCC-related signaling pathways have gained prominence. The present study aimed to evaluate the therapeutic potential of Arsenic Trioxide (ATO) concerning its antitumoral effects and the inhibition of the Hedgehog (HH) pathway in OSCC. Initially, ATO cytotoxicity was assessed in a panel of cell lines. Cell viability, cell cycle, death patterns, and cell morphology were analyzed, as well as the effect of ATO on the expression of HH pathway components. After the cytotoxic assay, HSC3 cells were chosen for all in vitro assays. ATO increased apoptotic cell death and nuclear fragmentation in the sub-G1 cell cycle phase and promoted changes in cell morphology. In addition, the reduced expression of GLI1 indicated that ATO inhibits HH activity. The present study provides evidence of ATO as an effective cytotoxic drug for oral cancer treatment in vitro. [ABSTRACT FROM AUTHOR]
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- 2022
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5. In silico approaches for drug repurposing in oncology: Protocol for a scoping review of existing evidence.
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Cavalcante, Bruno Raphael Ribeiro, Freitas, Raíza Dias, Siquara da Rocha, Leonardo de Oliveira, Rocha, Gisele Vieira, de Carvalho Pachêco, Túlio Cosme, Pereira Ramos, Pablo Ivan, and Gurgel Rocha, Clarissa Araújo
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DRUG repositioning , *ANTINEOPLASTIC agents , *SCIENCE databases , *WEB databases , *GREY literature - Abstract
Drug repurposing has been applied in the biomedical field to optimize the use of existing drugs, leading to a more efficient allocation of research resources. In oncology, this approach is particularly interesting, considering the high cost related to the discovery of new drugs with therapeutic potential. Computational methods have been applied to predict associations between drugs and their targets. However, drug repurposing has not always been promising and its efficiency has yet to be proven. Therefore, the present scoping review protocol was developed to screen the literature on how in silico strategies can be implemented in drug repurposing in oncology. The scoping review will be conducted according to the Arksey and O'Malley framework (2005) and the Joanna Briggs Institute recommendations. We will search the PubMed/MEDLINE, Embase, Scopus, and Web of Science databases, as well as the grey literature. We will include peer-reviewed research articles involving in silico strategies applied to drug repurposing in oncology, published between January 1, 2003, and December 31, 2021. Data will be charted and findings described according to review questions. We will report the scoping review using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Review guidelines (PRISMA-ScR). [ABSTRACT FROM AUTHOR]
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- 2022
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6. Physical exercise consequences on memory in obesity: A systematic review.
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De Sousa, Ricardo Augusto Leoni, Santos, Letícia Gomes, Lopes, Paulo Maurício, Cavalcante, Bruno Raphael Ribeiro, Improta‐Caria, Alex Cleber, and Cassilhas, Ricardo Cardoso
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OBESITY ,RESISTANCE training ,COGNITION disorders ,MEMORY loss ,EXERCISE intensity ,ANIMAL-assisted therapy - Abstract
Summary: Obesity is associated with changes in memory. Thus, the aim of this systematic review was to investigate the physical exercise consequences on memory in obesity. A search was carried out in the PubMed, Lilacs, and Scielo databases with the following descriptors: "physical exercise," "memory," and "obesity." A total of 16 studies were analyzed in this review. Low, moderate, and high intensity exercise training showed positive effects on memory in patients with obesity (100%). The animal models of obesity used in their physical exercise protocols: treadmill (72.7%) or wheel running (27.3%). Most of the animal studies (81.8%) revealed positive effects of the physical exercise protocol on memory in obesity. Mouse was the most commonly used animal (54.5%), and a 60% high‐fat diet (HFD) was the most commonly method used to induce obesity (82%). We did not identify any knockout model of obesity that was used to evaluate memory and used physical exercise as the main intervention. Thus, exercise training, independently if it is resistance or endurance training, seems to be an excellent intervention to prevent and inhibit cognitive impairment and memory loss on obese patients and animal models of obesity. [ABSTRACT FROM AUTHOR]
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- 2021
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7. Generation of integration-free iPS cell lines from three sickle cell disease patients from the state of Bahia, Brazil.
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Martins, Gabriele Louise Soares, Paredes, Bruno Diaz, Azevedo, Carine Machado, Sampaio, Gabriela Louise De Almeida, Nonaka, Carolina Kymie Vasques, Cavalcante, Bruno Raphael Ribeiro, Da Silva, Katia Nunes, Pereira, Ciro Silveira E., Soares, Milena Botelho Pereira, Dos Santos, Ricardo Ribeiro, and Souza, Bruno Solano De Freitas
- Abstract
Copyright of Stem Cell Research is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2018
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8. Modulation of MicroRNAs as a Potential Molecular Mechanism Involved in the Beneficial Actions of Physical Exercise in Alzheimer Disease.
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Improta-Caria, Alex Cleber, Nonaka, Carolina Kymie Vasques, Cavalcante, Bruno Raphael Ribeiro, De Sousa, Ricardo Augusto Leoni, Aras Júnior, Roque, and Souza, Bruno Solano de Freitas
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MICRORNA ,EXERCISE ,ALZHEIMER'S disease ,GENETIC regulation ,NON-coding RNA ,NEUROFIBRILLARY tangles ,MIDDLE-aged persons - Abstract
Alzheimer disease (AD) is one of the most common neurodegenerative diseases, affecting middle-aged and elderly individuals worldwide. AD pathophysiology involves the accumulation of beta-amyloid plaques and neurofibrillary tangles in the brain, along with chronic neuroinflammation and neurodegeneration. Physical exercise (PE) is a beneficial non-pharmacological strategy and has been described as an ally to combat cognitive decline in individuals with AD. However, the molecular mechanisms that govern the beneficial adaptations induced by PE in AD are not fully elucidated. MicroRNAs are small non-coding RNAs involved in the post-transcriptional regulation of gene expression, inhibiting or degrading their target mRNAs. MicroRNAs are involved in physiological processes that govern normal brain function and deregulated microRNA profiles are associated with the development and progression of AD. It is also known that PE changes microRNA expression profile in the circulation and in target tissues and organs. Thus, this review aimed to identify the role of deregulated microRNAs in the pathophysiology of AD and explore the possible role of the modulation of microRNAs as a molecular mechanism involved in the beneficial actions of PE in AD. [ABSTRACT FROM AUTHOR]
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- 2020
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9. Circulating miRNAs as Potential Biomarkers Associated with Cardiac Remodeling and Fibrosis in Chagas Disease Cardiomyopathy.
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Nonaka, Carolina Kymie Vasques, Macêdo, Carolina Thé, Cavalcante, Bruno Raphael Ribeiro, Alcântara, Adriano Costa de, Silva, Daniela Nascimento, Bezerra, Milena da Rocha, Caria, Alex Cleber Improta, Tavora, Fábio Rocha Fernandes, Neto, João David de Souza, Noya-Rabelo, Márcia Maria, Rogatto, Silvia Regina, Ribeiro dos Santos, Ricardo, Souza, Bruno Solano de Freitas, and Soares, Milena Botelho Pereira
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CHAGAS' disease ,HEART fibrosis ,CARDIOMYOPATHIES ,MICRORNA ,CARDIAC hypertrophy ,BIOMARKERS - Abstract
Chagas disease (CD) affects approximately 6–7 million people worldwide, from which 30% develop chronic Chagas cardiomyopathy (CCC), usually after being asymptomatic for years. Currently available diagnostic methods are capable of adequately identifying infected patients, but do not provide information regarding the individual risk of developing the most severe form of the disease. The identification of biomarkers that predict the progression from asymptomatic or indeterminate form to CCC, may guide early implementation of pharmacological therapy. Here, six circulating microRNAs (miR-19a-3p, miR-21-5p, miR-29b-3p, miR-30a-5p, miR-199b-5p and miR-208a-3p) were evaluated and compared among patients with CCC (n = 28), CD indeterminate form (n = 10) and healthy controls (n = 10). MiR-19a-3p, miR-21-5p, and miR-29b-3p were differentially expressed in CCC patients when compared to indeterminate form, showing a positive correlation with cardiac dysfunction, functional class, and fibrosis, and a negative correlation with ejection fraction and left ventricular strain. Cardiac tissue analysis confirmed increased expression of microRNAs in CCC patients. In vitro studies using human cells indicated the involvement of these microRNAs in the processes of cardiac hypertrophy and fibrosis. Our study suggests that miRNAs are involved in the process of cardiac fibrosis and remodeling presented in CD and indicate a group of miRNAs as potential biomarkers of disease progression in CCC. [ABSTRACT FROM AUTHOR]
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- 2019
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10. In silico approaches for drug repurposing in oncology: a scoping review.
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Cavalcante BRR, Freitas RD, Siquara da Rocha LO, Santos RSBD, Souza BSF, Ramos PIP, Rocha GV, and Gurgel Rocha CA
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Introduction: Cancer refers to a group of diseases characterized by the uncontrolled growth and spread of abnormal cells in the body. Due to its complexity, it has been hard to find an ideal medicine to treat all cancer types, although there is an urgent need for it. However, the cost of developing a new drug is high and time-consuming. In this sense, drug repurposing (DR) can hasten drug discovery by giving existing drugs new disease indications. Many computational methods have been applied to achieve DR, but just a few have succeeded. Therefore, this review aims to show in silico DR approaches and the gap between these strategies and their ultimate application in oncology. Methods: The scoping review was conducted according to the Arksey and O'Malley framework and the Joanna Briggs Institute recommendations. Relevant studies were identified through electronic searching of PubMed/MEDLINE, Embase, Scopus, and Web of Science databases, as well as the grey literature. We included peer-reviewed research articles involving in silico strategies applied to drug repurposing in oncology, published between 1 January 2003, and 31 December 2021. Results: We identified 238 studies for inclusion in the review. Most studies revealed that the United States, India, China, South Korea, and Italy are top publishers. Regarding cancer types, breast cancer, lymphomas and leukemias, lung, colorectal, and prostate cancer are the top investigated. Additionally, most studies solely used computational methods, and just a few assessed more complex scientific models. Lastly, molecular modeling, which includes molecular docking and molecular dynamics simulations, was the most frequently used method, followed by signature-, Machine Learning-, and network-based strategies. Discussion: DR is a trending opportunity but still demands extensive testing to ensure its safety and efficacy for the new indications. Finally, implementing DR can be challenging due to various factors, including lack of quality data, patient populations, cost, intellectual property issues, market considerations, and regulatory requirements. Despite all the hurdles, DR remains an exciting strategy for identifying new treatments for numerous diseases, including cancer types, and giving patients faster access to new medications., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Cavalcante, Freitas, Siquara da Rocha, Santos, Souza, Ramos, Rocha and Gurgel Rocha.)
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- 2024
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11. The Epigenetic Role of MiRNAs in Endocrine Crosstalk Between the Cardiovascular System and Adipose Tissue: A Bidirectional View.
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Soci UPR, Cavalcante BRR, Improta-Caria AC, and Roever L
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Overweight and obesity (OBT) is a serious health condition worldwide, and one of the major risk factors for cardiovascular disease (CVD), the main reason for morbidity and mortality worldwide. OBT is the proportional increase of Adipose Tissue (AT) compared with other tissue and fluids, associated with pathological changes in metabolism, hemodynamic overload, cytokine secretion, systemic inflammatory profile, and cardiac metabolism. In turn, AT is heterogeneous in location, and displays secretory capacity, lipolytic activation, insulin sensitivity, and metabolic status, performing anatomic, metabolic, and endocrine functions. Evidence has emerged on the bidirectional crosstalk exerted by miRNAs as regulators between the heart and AT on metabolism and health conditions. Here, we discuss the bidirectional endocrine role of miRNAs between heart and AT, rescuing extracellular vesicles' (EVs) role in cell-to-cell communication, and the most recent results that show the potential of common therapeutic targets through the elucidation of parallel and ⁄or common epigenetic mechanisms., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Soci, Cavalcante, Improta-Caria and Roever.)
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- 2022
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