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3. Relative validity of the Planetary Health Diet Index by comparison with usual nutrient intakes, plasma food consumption biomarkers, and adherence to the Mediterranean diet among European adolescents: the HELENA study

Author

Cacau, Leandro Teixeira, Hanley-Cook, Giles T., Huybrechts, Inge, De Henauw, Stefaan, Kersting, Mathilde, Gonzalez-Gross, Marcela, Gottrand, Frederic, Ferrari, Marika, Nova, Esther, Castillo, Manuel J., Molnár, Dénes, Widhalm, Kurt, Androutsos, Odysseas, Manios, Yannis, Stehle, Peter, Lachat, Carl, Marchioni, Dirce Maria, and Moreno, Luis A.

Published
2023
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11. The Effects of High-Intensity Interval Training and Moderate Alcohol Consumption on Cognitive Performance—A Multidisciplinary Intervention in Young Healthy Adults.

Author

Molina-Hidalgo, Cristina, Amaro-Gahete, Francisco J., Peven, Jamie C., Erickson, Kirk I., Catena, Andres, and Castillo, Manuel J.

Abstract

Background. The main purpose of this study was to determine the effects of a high-intensity interval training (HIIT) intervention in the context of moderate alcohol consumption on cognitive performance in healthy young adults. Methods. We conducted a 10-week HIIT program along with four types of beverages with/without alcohol content. A total of 75 healthy adults (18–40 years old; 46% female) were allocated to either a control Non-Training group or an HIIT program group (2 days/week). Using block randomization, participants in the HIIT group were further allocated to an HIIT-Alcohol group (alcohol beer or sparkling water with vodka added, 5.4%) or an HIIT-NonAlcohol group (sparkling water or non-alcohol beer, 0.0%). The control group was instructed to maintain an active lifestyle but did not undergo any regular training. A comprehensive neuropsychological battery was used to evaluate cognitive performance (i.e., memory, working memory, processing speed, inhibitory control, and verbal fluency). Changes from baseline to week 10 were included in the main analyses. Results. All groups improved in all neuropsychological measures (all p ≤ 0.001), independent of sex and alcohol consumption, with no statistical differences between groups (all p > 0.05). Furthermore, larger increases in maximal oxygen uptake were associated with greater improvements in processing speed, inhibitory control, and verbal fluency (all p < 0.050). Conclusions. Although the improvements found in cognitive performance cannot be attributed to the HIIT intervention, no significant impairments in cognitive functions were noted due to moderate alcohol intake. Furthermore, our results confirmed that exercise-induced physical fitness improvements were associated with cognitive performance enhancements in young healthy adults. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Effect of Different Exercise Training Modalities on Fasting Levels of Oxylipins and Endocannabinoids in Middle-Aged Sedentary Adults: A Randomized Controlled Trial.

Author

Jurado-Fasoli, Lucas, Yang, Wei, Kohler, Isabelle, Dote-Montero, Manuel, Osuna-Prieto, Francisco J., Di, Xinyu, Hankemeier, Thomas, Krekels, Elke H.J., Harms, Amy C., Castillo, Manuel J., Amaro-Gahete, Francisco J., and Martinez-Tellez, Borja

Subjects
SEDENTARY lifestyles, FASTING, UNSATURATED fatty acids, BODY composition, STATISTICS, PHOTON absorptiometry, BLOOD plasma, EXERCISE physiology, NEUROTRANSMITTERS, BLOOD collection, FOOD diaries, RANDOMIZED controlled trials, PRE-tests & post-tests, PHYSICAL activity, EXERCISE, DRUGS, QUESTIONNAIRES, STATISTICAL sampling, HIGH-intensity interval training, DATA analysis, MIDDLE age, ADULTS
Abstract

This study aimed to investigate the effects of different exercise training programs on fasting plasma levels of oxylipins, endocannabinoids (eCBs), and eCBs-like molecules in middle-aged sedentary adults. A 12-week randomized controlled trial was conducted using a parallel group design. Sixty-five middle-aged adults (40–65 years old) were randomly assigned to: (a) no exercise (control group), (b) concurrent training based on international physical activity recommendations (PAR group), (c) high-intensity interval training (HIIT group), and (d) HIIT together with whole-body electromyostimulation (HIIT + EMS group). Plasma levels of oxylipins, eCBs, and eCBs-like molecules were determined in plasma samples before and after the intervention using targeted lipidomics. Body composition was assessed through dual-energy X-ray absorptiometry, and dietary intake through a food frequency questionnaire and three nonconsecutive 24-hr recalls. The physical activity recommendations, HIIT, and HIIT-EMS groups showed decreased plasma levels of omega-6 and omega-3-derived oxylipins, and eCBs and eCBs-like molecules after 12 weeks (all Δ ≤ −0.12; all p <.05). Importantly, after Bonferroni post hoc corrections, the differences in plasma levels of omega-6 and omega-3 oxylipins were not statistically significant compared with the control group (all p >.05). However, after post hoc corrections, plasma levels of anandamide and oleoylethanolamide were increased in the physical activity recommendations group compared with the control group (anandamide: Δ = 0.05 vs. −0.09; oleoylethanolamide: Δ = −0.12 vs. 0.013, all p ≤.049). In conclusion, this study reports that a 12-week exercise training intervention, independent of the modality applied, does not modify fasting plasma levels of omega-6 and omega-3 oxylipins, eCBs, and eCBs-like molecules in middle-aged sedentary adults. [ABSTRACT FROM AUTHOR]

Published
2022
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19. Do dietary patterns determine levels of vitamin B6, folate, and vitamin B12 intake and corresponding biomarkers in European adolescents? The Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study

Author

Moreno, Luis A., Fleta, Jesús, Casajús, José A., Rodríguez, Gerardo, Tomás, Concepción, Mesana, María I., Vicente-Rodríguez, Germán, Villarroya, Adoración, Gil, Carlos M., Ara, Ignacio, Alvira, Juan Fernández, Bueno, Gloria, Lázaro, Aurora, Bueno, Olga, León, Juan F., Garagorri, Jesús M.<ce:sup loc='post">a</ce:sup>, Bueno, Manuel, Labayen, Idoia, Iglesia, Iris, Bel, Silvia, Marco, Luis A. Gracia, Mouratidou, Theodora, Santaliestra-Pasías, Alba, González-Gil, Esther, De Miguel-Etayo, Pilar, Almárcegui, Cristina Julián, Miguel-Berges, Mary, Iguacel, Isabel, Marcos, Ascensión, Wärnberg, Julia, Nova, Esther, Gómez, Sonia, Díaz, Ligia Esperanza, Romeo, Javier, Veses, Ana, Zapatera, Belén, Pozo, Tamara, Martínez, David, Beghin, Laurent, Libersa, Christian, Gottrand, Frédéric, Iliescu, Catalina, Von Berlepsch, Juliana, Kersting, Mathilde, Sichert-Hellert, Wolfgang, Koeppen, Ellen, Molnár, Dénes, Erhardt, Eva, Csernus, Katalin, Török, Katalin, Bokor, Szilvia, Angster, Mrs, Nagy, Enikö, Kovács, Orsolya, Répasi, Judit, Kafatos, Anthony, Codrington, Caroline, Plada, María, Papadaki, Angeliki, Sarri, Katerina, Viskadourou, Anna, Hatzis, Christos, Kiriakakis, Michael, Tsibinos, George, Vardavas, Constantine, Sbokos, Manolis, Protoyeraki, Eva, Fasoulaki, Maria, Stehle, Peter, Pietrzik, Klaus, González-Gross, Marcela, Breidenassel, Christina, Spinneker, Andre, Al-Tahan, Jasmin, Segoviano, Miriam, Berchtold, Anke, Bierschbach, Christine, Blatzheim, Erika, Schuch, Adelheid, Pickert, Petra, Castillo, Manuel J., Gutiérrez, Ángel, Ortega, Francisco B., Ruiz, Jonatan R., Artero, Enrique G., España, Vanesa, Jiménez-Pavón, David, Chillón, Palma, Sánchez-Muñoz, Cristóbal, Cuenca, Magdalena, Arcella, Davide, Azzini, Elena, Barison, Emma, Bevilacqua, Noemi, Buonocore, Pasquale, Catasta, Giovina, Censi, Laura, Ciarapica, Donatella, D'Acapito, Paola, Ferrari, Marika, Galfo, Myriam, Donne, Cinzia Le, Leclercq, Catherine, Maiani, Giuseppe, Mauro, Beatrice, Mistura, Lorenza, Pasquali, Antonella, Piccinelli, Raffaela, Polito, Angela, Roccaldo, Romana, Spada, Raffaella, Sette, Stefania, Zaccaria, Maria, Scalfi, Luca, Vitaglione, Paola, Montagnese, Concetta, De Bourdeaudhuij, Ilse, De Henauw, Stefaan, De Vriendt, Tineke, Maes, Lea, Matthys, Christophe, Vereecken, Carine, de Maeyer, Mieke, Ottevaere, Charlene, Huybrechts, Inge, Widhalm, Kurt, Phillipp, Katharina, Dietrich, Sabine, Manios, Yannis, Grammatikaki, Eva, Bouloubasi, Zoi, Cook, Tina Louisa, Eleutheriou, Sofia, Consta, Orsalia, Moschonis, George, Katsaroli, Ioanna, Kraniou, George, Papoutsou, Stalo, Keke, Despoina, Petraki, Ioanna, Bellou, Elena, Tanagra, Sofia, Kallianoti, Kostalenia, Argyropoulou, Dionysia, Tsikrika, Stamatoula, Karaiskos, Christos, Dallongeville, Jean, Meirhaeghe, Aline, Sjöstrom, Michael, Hagströmer, María, Wennlöf, Anita Hurtig, Hallström, Lena, Patterson, Emma, Kwak, Lydia, Rizzo, Nico, Sánchez-Molero, Jackie, Castelló, Sara, Picó, Elena, Navarro, Maite, Viadel, Blanca, Carreres, José Enrique, Merino, Gema, Sanjuán, Rosa, Lorente, María, Sánchez, María José, Gilbert, Chantal, Thomas, Sarah, Allchurch, Elaine, Burgess, Peter, Hall, Gunnar, Astrom, Annika, Sverkén, Anna, Broberg, Agneta, Masson, Annick, Lehoux, Claire, Brabant, Pascal, Pate, Philippe, Fontaine, Laurence, Sebok, Andras, Kuti, Tunde, Hegyi, Adrienn, Maldonado, Cristina, Llorente, Ana, García, Emilio, von Fircks, Holger, Hallberg, Marianne Lilja, Messerer, Maria, Larsson, Mats, Fredriksson, Helena, Adamsson, Viola, Börjesson, Ingmar, Fernández, Laura, Smillie, Laura, Wills, Josephine, Pedrero-Chamizo, Raquel, Meléndez, Agustín, Valtueña, Jara, Albers, Ulrike, Benito, Pedro J., Lorente, Juan José Gómez, Cañada, David, Urzanqui, Alejandro, Torres, Rosa María, Navarro, Paloma, Santabárbara, Javier, Fernández-Alvira, Juan M., Santaliestra-Pasías, Alba M., De la O Puerta, Alejandro, and Plada, Maria

Published
2018
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21. Single nucleotide polymorphisms of ADIPOQ gene associated with cardiovascular disease risk factors in European adolescents: the Healthy Lifestyle in Europe by Nutrition in Adolescence study

Author

Salazar-Tortosa, Diego F., Pascual-Gamarra, Jose M., Labayen, Idoia, Rupérez, Azahara I., Censi, Laura, Béghin, Laurent, Michels, Nathalie, González-Gross, Marcela, Manios, Yannis, Lambrinou, Christina-Paulina, Moreno, Luis A., Meirhaeghe, Aline, Castillo, Manuel J., and Ruiz, Jonatan R.

Published
2020
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22. Fragmentation of daily rhythms associates with obesity and cardiorespiratory fitness in adolescents: The HELENA study

Author

Garaulet, Marta, Martinez-Nicolas, Antonio, Ruiz, Jonatan R., Konstabel, Kenn, Labayen, Idoia, González-Gross, Marcela, Marcos, Ascensión, Molnar, Dénes, Widhalm, Kurt, Casajús, Jose Antonio, De Henauw, Stefaan, Kafatos, Anthony, Breidenassel, Christina, Sjöström, Michael, Castillo, Manuel J., Moreno, Luis A., Madrid, Juan A., and Ortega, Francisco B.

Published
2017
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24. Prevalence of Metabolically Healthy but Overweight/Obese Phenotype and Its Association With Sedentary Time, Physical Activity, and Fitness

Author

Cadenas-Sanchez, Cristina, Ruiz, Jonatan R., Labayen, Idoia, Huybrechts, Inge, Manios, Yannis, González-Gross, Marcela, Breidenassel, Christina, Kafatos, Anthony, De Henauw, Stefaan, Vanhelst, Jeremy, Widhalm, Kurt, Molnar, Denes, Bueno, Gloria, Censi, Laura, Plada, María, Sjöström, Michael, Moreno, Luis A., Castillo, Manuel J., and Ortega, Francisco B.

Published
2017
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27. Physical exercise improves memory in sedentary middle‐aged adults: Are these exercise‐induced benefits associated with S‐Klotho and 1,25‐dihydroxivitamin D? The FIT‐AGEING randomized controlled trial.

Author

Vázquez‐Lorente, Héctor, De‐la‐O, Alejandro, Carneiro‐Barrera, Almudena, Molina‐Hidalgo, Cristina, Castillo, Manuel J., and Amaro‐Gahete, Francisco J.

Subjects
SEDENTARY lifestyles, EVALUATION of human services programs, CALCITRIOL, COGNITION, CELL receptors, EXERCISE physiology, PHYSICAL activity, RANDOMIZED controlled trials, COMPARATIVE studies, AGING, GLUCURONIDASE, DESCRIPTIVE statistics, EXERCISE intensity, RESEARCH funding, HIGH-intensity interval training, STATISTICAL sampling, BLOOD, MIDDLE age
Abstract

We aimed to investigate the effect of three types of exercise interventions on memory (i.e., immediate memory (IM), long‐term memory (LTM), and recognition). We also investigated whether exercise‐induced changes in circulating S‐Klotho and 1,25‐dihydroxivitamin D (1,25(OH)2D) levels were related to those observed in memory in healthy middle‐aged sedentary adults. A 12‐week randomized controlled trial was performed with a parallel‐group design. Seventy‐four participants (45–65 years old: 53% women) were randomly assigned to (1) no exercise (control) group, (2) concurrent training based on the international physical activity recommendations (PAR) group, (3) high‐intensity interval training (HIIT) group, or (4) HIIT plus whole‐body electromyostimulation (HIIT‐EMS) group. Memory outcomes were assessed using the Wechsler Memory Scale‐third edition. S‐Klotho plasma levels were determined according to a solid‐phase sandwich enzyme‐linked immunosorbent assay kit while 1,25(OH)2D plasma levels were measured using a DiaSorin‐Liaison immunochemiluminometric analyzer. IM‐Verbal Paired Associates (IM‐VPA) and IM‐Logical Memory (IM‐LM) were improved in both the HIIT and HIIT‐EMS groups compared with the control group (all p ≤ 0.045). Exercise‐induced changes in S‐Klotho plasma levels were positively associated with those observed in IM, LTM, and recognition (all p ≤ 0.007), whereas exercise‐induced changes in 1,25(OH)2D plasma levels were directly related to changes in IM and LTM (all p ≤ 0.048). In conclusion, a 12‐week HIIT intervention with or without WB‐EMS seems to be the most effective exercise program to improve IM. The significant and positive associations between exercise‐induced changes in S‐Klotho and 1,25(OH)2D levels with those observed in memory outcomes suggest that these factors may be potentially related to exercise‐induced improvements of memory in middle‐aged adults. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Intra-Assessment Resting Metabolic Rate Variability Is Associated with Cardiometabolic Risk Factors in Middle-Aged Adults.

Author

Alcantara, Juan M. A., Osuna-Prieto, Francisco J., Castillo, Manuel J., Plaza-Florido, Abel, and Amaro-Gahete, Francisco J.

Subjects
MIDDLE-aged persons, BODY composition, CARDIOPULMONARY fitness, OXYGEN consumption, CARBON dioxide
Abstract

The intra-assessment resting metabolic rate variability is related to cardiometabolic health, as suggested by previous literature. We studied whether that variability (expressed as coefficient of variation [CV; %]) for oxygen consumption (VO2), carbon dioxide production (VCO2), respiratory exchange ratio (RER), and resting energy expenditure (REE) is similar between men and women, and if is similarly associated with cardiometabolic risk factors. Gas exchange in 72 middle-aged adults was measured by indirect calorimetry. Anthropometrics and body composition, cardiorespiratory fitness, circulating cardiometabolic risk factors, and heart rhythm parameters were also determined. Men and women presented similar intra-assessment resting metabolic rate variability (all p > 0.05). Notably, in men, CV for RER was positively associated with BMI and adiposity (both standardized β = 0.35, Ps ≤ 0.048), while CVs for VO2, VCO2, and REE were negatively associated (standardized β ranged from −0.37 to −0.46, all p ≤ 0.036) with cardiometabolic risk factors. In women, CVs for VCO2 and REE were negatively associated with adiposity (both standardized β = −0.36, Ps ≤ 0.041) and cardiometabolic risk Z-score (standardized β = −0.40 and −0.38, respectively, Ps ≤ 0.05). In conclusion, intra-assessment resting metabolic rate variability could be considered an indicator of cardiometabolic health in middle-aged adults. [ABSTRACT FROM AUTHOR]

Published
2023
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29. Physical Activity Is Associated with Attention Capacity in Adolescents

Author

Moreno, Luis A., Gottrand, Fréderic, De Henauw, Stefaan, González-Gross, Marcela, Gilbert, Chantal, Kafatos, Anthony, Libersa, Christian, Sánchez, Jackie, Kersting, Mathilde, Sjöstrom, Michael, Molnár, Dénes, Dallongeville, Jean, Hall, Gunnar, Maes, Lea, Scalfi, Luca, Meléndez, Pilar, Fleta, Jesús, Casajús, José A., Rodríguez, Gerardo, Tomás, Concepción, Mesana, María I., Vicente-Rodríguez, Germán, Villarroya, Adoración, Gil, Carlos M., Ara, Ignacio, Revenga, Juan, Lachen, Carmen, Alvira, Juan Fernández, Bueno, Gloria, Lázaro, Aurora, Bueno, Olga, León, Juan F., Garagorri, Jesús Mª, Bueno, Manuel, Rey López, Juan Pablo, Iglesia, Iris, Velasco, Paula, Bel, Silvia, Marcos, Ascensión, Wärnberg, Julia, Nova, Esther, Gómez, Sonia, Díaz, Esperanza Ligia, Romeo, Javier, Veses, Ana, Puertollano, Mari Angeles, Zapatera, Belén, Pozo, Tamara, Martínez, David, Beghin, Laurent, Gottrand, Frédéric, Iliescu, Catalina, Von Berlepsch, Juliana, Sichert-Hellert, Wolfgang, Koeppen, Ellen, Molnar, Dénes, Erhardt, Eva, Csernus, Katalin, Török, Katalin, Bokor, Szilvia, Angster, Miklós, Nagy, Enikö, Kovács, Orsolya, Repásy, Judit, Codrington, Caroline, Plada, María, Papadaki, Angeliki, Sarri, Katerina, Viskadourou, Anna, Hatzis, Christos, Kiriakakis, Michael, Tsibinos, George, Vardavas, Constantine, Sbokos, Manolis, Protoyeraki, Eva, Fasoulaki, Maria, Stehle, Peter, Pietrzik, Klaus, Breidenassel, Christina, Spinneker, Andre, Al-Tahan, Jasmin, Segoviano, Miriam, Berchtold, Anke, Bierschbach, Christine, Blatzheim, Erika, Schuch, Adelheid, Pickert, Petra, Castillo, Manuel J., Gutiérrez, Ángel, Ortega, Francisco B., Ruiz, Jonatan R., Artero, Enrique G., España-Romero, Vanesa, Jiménez-Pavón, David, Chillón, Palma, Cuenca-García, Magdalena, Arcella, Davide, Azzini, Elena, Barrison, Emma, Bevilacqua, Noemi, Buonocore, Pasquale, Catasta, Giovina, Censi, Laura, Ciarapica, Donatella, D'Acapito, Paola, Ferrari, Marika, Galfo, Myriam, Le Donne, Cinzia, Leclercq, Catherine, Maiani, Giuseppe, Mauro, Beatrice, Mistura, Lorenza, Pasquali, Antonella, Piccinelli, Raffaela, Polito, Angela, Spada, Raffaella, Sette, Stefania, Zaccaria, Maria, Vitaglione, Paola, Montagnese, Concetta, De Bourdeaudhuij, Ilse, De Vriendt, Tineke, Matthys, Christophe, Vereecken, Carine, de Maeyer, Mieke, Ottevaere, Charlene, Huybrechts, Inge, Widhalm, Kurt, Phillipp, Katharina, Dietrich, Sabine, Kubelka, Birgit, Boriss-Riedl, Marion, Manios, Yannis, Grammatikaki, Eva, Bouloubasi, Zoi, Cook, Tina Louisa, Eleutheriou, Sofia, Consta, Orsalia, Moschonis, George, Katsaroli, Ioanna, Kraniou, George, Papoutsou, Stalo, Keke, Despoina, Petraki, Ioanna, Bellou, Elena, Tanagra, Sofia, Kallianoti, Kostalenia, Argyropoulou, Dionysia, Kondaki, Katerina, Tsikrika, Stamatoula, Karaiskos, Christos, Meirhaeghe, Aline, Bergman, Patrick, Hagströmer, María, Hallström, Lena, Hallberg, Mårten, Poortvliet, Eric, Rizzo, Nico, Beckman, Linda, Wennlöf, Anita Hurtig, Patterson, Emma, Kwak, Lydia, Cernerud, Lars, Tillgren, Per, Sörensen, Stefaan, Sánchez-Molero, Jackie, Picó, Elena, Navarro, Maite, Viadel, Blanca, Carreres, José Enrique, Merino, Gema, Sanjuán, Rosa, Lorente, María, Sánchez, María José, Castelló, Sara, Thomas, Sarah, Allchurch, Elaine, Burguess, Peter, Astrom, Annika, Sverkén, Anna, Broberg, Agneta, Masson, Annick, Lehoux, Claire, Brabant, Pascal, Pate, Philippe, Fontaine, Laurence, Sebok, Andras, Kuti, Tunde, Hegyi, Adrienn, Maldonado, Cristina, Llorente, Ana, García, Emilio, von Fircks, Holger, Hallberg, Marianne Lilja, Messerer, Maria, Larsson, Mats, Fredriksson, Helena, Adamsson, Viola, Börjesson, Ingmar, Fernández, Laura, Smillie, Laura, Wills, Josephine, Meléndez, Agustín, Benito, Pedro J., Calderón, Javier, Valtueña, Jara, Navarro, Paloma, Urzanqui, Alejandro, Albers, Ulrike, Pedrero, Raquel, Gómez Lorente, Juan José, Vanhelst, Jérémy, Béghin, Laurent, Duhamel, Alain, Molnar, Denes, De Henauw, Sefaan, and Sjöström, Michael

Published
2016
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30. Fit‐Fat Index is better associated with heart rate variability compared to fitness and fatness alone as indicators of cardiometabolic human health.

Author

Navarro‐Lomas, Ginés, Plaza‐Florido, Abel, De‐la‐O, Alejandro, Castillo, Manuel J., and Amaro‐Gahete, Francisco J.

Subjects
HEART beat, AEROBIC capacity, OBESITY, CARDIOPULMONARY fitness, AUTONOMIC nervous system, OXYGEN consumption
Abstract

Objectives: Cardiorespiratory fitness and fatness indicators have been related to heart rate variability (HRV) parameters. The Fit‐Fat Index (FFI) is a single index combining cardiorespiratory fitness and fatness indicators. To the best of our knowledge, no studies have previously analyzed whether FFI are related to cardiac autonomic nervous system activity assessed through HRV parameters. This study aimed (i) to examine the association of cardiorespiratory fitness, fatness indicators, and FFI with HRV parameters; and (ii) to report what of the different fatness indicators included in FFI is better associated with HRV parameters in sedentary adults. Methods: One hundred and fifty healthy adults (74 women; 76 men), aged between 18 and 65 years old, participated in this cross‐sectional study. We measured cardiorespiratory fitness (maximal oxygen consumption) and fatness indicators (waist‐to‐height ratio [WHR], fat mass percentage [FM%] and visceral adipose tissue [VAT]). Three FFIs were calculated as the quotient between cardiorespiratory fitness and one out of three possible fatness indicators: Fit‐Fat Index calculated waist‐to‐height ratio (FFIWHR), Fit‐Fat Index calculated with FM% (FFIFM%), and Fit‐Fat Index calculated with VAT (FFIVAT). HRV parameters were measured in resting conditions using a Polar RS800CX. Results: FFIWTHR, FFIFM% and FFIVAT were related to different HRV parameters (β ranges between −0.507 and 0.529; R2 ranges between 0.096 and 0.275; all p <.001) and the association was stronger with HRV parameters than the isolated fitness or fatness indicators (β ranges between −0.483 and 0.518; R2 ranges between 0.071 and 0.263; all p <.001). FFIVAT was the index more consistently associated with HRV parameters (β ranges between −0.507 and 0.529; R2 ranges between 0.235 and 0.275; all p <.001). Conclusion: Our study suggests that compound FFIs are better predictors of HRV parameters than either cardiorespiratory fitness or fatness indicators alone. The FFIVAT was the best index in terms of its association to HRV. [ABSTRACT FROM AUTHOR]

Published
2023
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31. Amino acids intake and physical fitness among adolescents

Author

Gracia-Marco, Luis, Bel-Serrat, Silvia, Cuenca-Garcia, Magdalena, Gonzalez-Gross, Marcela, Pedrero-Chamizo, Raquel, Manios, Yannis, Marcos, Ascensión, Molnar, Denes, Widhalm, Kurt, Polito, Angela, Vanhelst, Jeremy, Hagströmer, Maria, Sjöström, Michael, Kafatos, Anthony, de Henauw, Stefaan, Gutierrez, Ángel, Castillo, Manuel J., Moreno, Luis A., and On behalf of the HELENA Study Group

Published
2017
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32. Foods contributing to vitamin B6, folate, and vitamin B12 intakes and biomarkers status in European adolescents: The HELENA study

Author

Iglesia, Iris, Mouratidou, Theodora, González-Gross, Marcela, Huybrechts, Inge, Breidenassel, Christina, Santabárbara, Javier, Díaz, Ligia-Esperanza, Hällström, Lena, De Henauw, Stefaan, Gottrand, Frédéric, Kafatos, Anthony, Widhalm, Kurt, Manios, Yannis, Molnar, Denes, Stehle, Peter, Moreno, Luis A., Moreno, Luis A., Fleta, Jesús, Casajús, José A., Rodríguez, Gerardo, Tomás, Concepción, Mesana, María I., Vicente-Rodríguez, Germán, Villarroya, Adoración, Gil, Carlos M., Ara, Ignacio, Alvira, Juan Fernández, Bueno, Gloria, Lázaro, Aurora, Bueno, Olga, León, Juan F., Garagorri, Jesús Mª, Bueno, Manuel, Labayen, Idoia, Iglesia, Iris, Bel, Silvia, Gracia Marco, Luis A., Mouratidou, Theodora, Santaliestra-Pasías, Alba, Iglesia, Iris, González-Gil, Esther, De Miguel-Etayo, Pilar, Almárcegui, Cristina Julián, Miguel-Berges, Mary, Iguacel, Isabel, Marcos, Ascensión, Wärnberg, Julia, Nova, Esther, Gómez, Sonia, Díaz, Ligia Esperanza, Romeo, Javier, Veses, Ana, Zapatera, Belén, Pozo, Tamara, Martínez, David, Beghin, Laurent, Libersa, Christian, Gottrand, Frédéric, Iliescu, Catalina, Von Berlepsch, Juliana, Kersting, Mathilde, Sichert-Hellert, Wolfgang, Koeppen, Ellen, Molnar, Dénes, Erhardt, Eva, Csernus, Katalin, Török, Katalin, Bokor, Szilvia, Angster, Mrs., Nagy, Enikö, Kovács, Orsolya, Répasi, Judit, Kafatos, Anthony, Codrington, Caroline, Plada, María, Papadaki, Angeliki, Sarri, Katerina, Viskadourou, Anna, Hatzis, Christos, Kiriakakis, Michael, Tsibinos, George, Vardavas, Constantine, Sbokos, Manolis, Protoyeraki, Eva, Fasoulaki, Maria, Stehle, Peter, Pietrzik, Klaus, González-Gross, Marcela, Breidenassel, Christina, Spinneker, Andre, Al-Tahan, Jasmin, Segoviano, Miriam, Berchtold, Anke, Bierschbach, Christine, Blatzheim, Erika, Schuch, Adelheid, Pickert, Petra, Castillo, Manuel J., Gutiérrez, Ángel, Ortega, Francisco B., Ruiz, Jonatan R., Artero, Enrique G., España, Vanesa, Jiménez-Pavón, David, Chillón, Palma, Sánchez-Muñoz, Cristóbal, Cuenca, Magdalena, Arcella, Davide, Azzini, Elena, Barrison, Emma, Bevilacqua, Noemi, Buonocore, Pasquale, Catasta, Giovina, Censi, Laura, Ciarapica, Donatella, D’Acapito, Paola, Ferrari, Marika, Galfo, Myriam, Le Donne, Cinzia, Leclercq, Catherine, Maiani, Giuseppe, Mauro, Beatrice, Mistura, Lorenza, Pasquali, Antonella, Piccinelli, Raffaela, Polito, Angela, Roccaldo, Romana, Spada, Raffaella, Sette, Stefania, Zaccaria, Maria, Scalfi, Luca, Vitaglione, Paola, Montagnese lyName>, Concetta, De Bourdeaudhuij, Ilse, De Henauw, Stefaan, De Vriendt, Tineke, Maes, Lea, Matthys, Christophe, Vereecken, Carine, de Maeyer, Mieke, Ottevaere, Charlene, Huybrechts, Inge, Widhalm, Kurt, Phillipp, Katharina, Dietrich, Sabine, Kubelka, Birgit, Boriss-Riedl, Marion, Manios, Yannis, Grammatikaki, Eva, Bouloubasi, Zoi, Cook, Tina Louisa, Eleutheriou, Sofia, Consta, Orsalia, Moschonis, George, Katsaroli, Ioanna, Kraniou, George, Papoutsou, Stalo, Keke, Despoina, Petraki, Ioanna, Bellou, Elena, Tanagra, Sofia, Kallianoti, Kostalenia, Argyropoulou, Dionysia, Tsikrika, Stamatoula, Karaiskos, Christos, Dallongeville, Jean, Meirhaeghe, Aline, Sjöstrom, Michael, Ruiz, Jonatan R., Ortega, Francisco B., Hagströmer, María, Wennlöf, Anita Hurtig, Hallström, Lena, Patterson, Emma, Kwak, Lydia, Wärnberg, Julia, Rizzo, Nico, Sánchez-Molero, Jackie, Castelló, Sara, Picó, Elena, Navarro, Maite, Viadel, Blanca, Carreres, José Enrique, Merino, Gema, Sanjuán, Rosa, Lorente, María, Sánchez, María José, Gilbert, Chantal, Thomas, Sarah, Allchurch, Elaine, Burgess, Peter, Hall, Gunnar, Astrom, Annika, Sverkén, Anna, Broberg, Agneta, Masson, Annick, Lehoux, Claire, Brabant, Pascal, Pate, Philippe, Fontaine, Laurence, Sebok, Andras, Kuti, Tunde, Hegyi, Adrienn, Maldonado, Cristina, Llorente, Ana, García, Emilio, von Fircks, Holger, Hallberg, Marianne Lilja, Messerer, Maria, Larsson, Mats, Fredriksson, Helena, Adamsson, Viola, Börjesson, Ingmar, Fernández, Laura, Smillie, Laura, Wills, Josephine, González-Gross, Marcela, Pedrero-Chamizo, Raquel, Meléndez, Agustín, Valtueña, Jara, Jiménez-Pavón, David, Albers, Ulrike, Benito, Pedro J., Lorente, Juan José Gómez, Cañada, David, Urzanqui, Alejandro, Torres, Rosa María, Navarro, Paloma, and on the behalf of HELENA study group

Published
2017
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33. Comparison of definitions for the metabolic syndrome in adolescents. The HELENA study

Author

Vanlancker, Tine, Schaubroeck, Emmily, Vyncke, Krishna, Cadenas-Sanchez, Cristina, Breidenassel, Christina, González-Gross, Marcela, Gottrand, Frederic, Moreno, Luis A., Beghin, Laurent, Molnár, Denes, Manios, Yannis, Gunter, Marc J., Widhalm, Kurt, Leclercq, Catherine, Dallongeville, Jean, Ascensión, Marcos, Kafatos, Anthony, Castillo, Manuel J., De Henauw, Stefaan, Ortega, Francisco B., Huybrechts, Inge, and on behalf of the HELENA project group*

Published
2017
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37. Influence of sex, age, pubertal maturation and body mass index on circulating white blood cell counts in healthy European adolescents—the HELENA study

Author

Pérez-de-Heredia, Fátima, Gómez-Martínez, Sonia, Díaz, Ligia-Esperanza, Veses, Ana M., Nova, Esther, Wärnberg, Julia, Huybrechts, Inge, Vyncke, Krishna, Androutsos, Odysseas, Ferrari, Marika, Palacios, Gonzalo, Wastlund, Acki, Kovács, Éva, Gottrand, Frédéric, González-Gross, Marcela, Castillo, Manuel J., Sjöstrom, Michael, Manios, Yannis, Kafatos, Anthony, Molnár, Denes, Widhalm, Kurt, Moreno, Luis A., Marcos, Ascensión, and on behalf of the HELENA Study Group

Published
2015
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42. Developing a risk assessment tool for identifying individuals at high risk for developing insulin resistance in European adolescents: the HELENA-IR score.

Author

Kondakis, Katerina, Grammatikaki, Evangelia, Kondakis, Marios, Molnar, Denes, Gómez-Martínez, Sonia, González-Gross, Marcela, Kafatos, Anthony, Manios, Yannis, Pavón, David Jiménez, Gottrand, Frédéric, Beghin, Laurent, Kersting, Mathilde, Castillo, Manuel J., Moreno, Luis A., and De Henauw, Stefaan

Abstract

To develop and validate an easy-to-use screening tool for identifying adolescents at high-risk for insulin resistance (IR). Α total of 1,053 adolescents (554 females), aged 12.5 to 17.5 years with complete data on glucose and insulin levels were included. Body mass index (BMI), fat mass index (FMI) and the homeostasis model assessment for insulin resistance (HOMA-IR) were calculated. VO2max was predicted using 20 m multi-stage fitness test. The population was randomly separated into two cohorts for the development (n=702) and validation (n=351) of the index, respectively. Factors associated with high HOMA-IR were identified by Spearman correlation in the development cohort; multiple logistic regression was performed for all identified independent factors to develop a score index. Finally, receiver operating characteristic (ROC) analysis was performed in the validation cohort and was used to define the cut-off values that could identify adolescents above the 75th and the 95th percentile for HOMA-IR. BMI and VO2max significantly identified high HOMA-IR in males; and FMI, TV watching and VO2max in females. The HELENA-IR index scores range from 0 to 29 for males and 0 to 43 for females. The Area Under the Curve, sensitivity and specificity for identifying males above the 75th and 95th of HOMA-IR percentiles were 0.635 (95%CI: 0.542–0.725), 0.513 and 0.735, and 0.714 (95%CI: 0.499–0.728), 0.625 and 0.905, respectively. For females, the corresponding values were 0.632 (95%CI: 0.538–0.725), 0.568 and 0.652, and 0.708 (95%CI: 0.559–0.725), 0.667 and 0.617, respectively. Simple algorithms were created using the index cut-off scores. Paediatricians or physical education teachers can use easy-to-obtain and non-invasive measures to apply the HELENA-IR score and identify adolescents at high risk for IR, who should be referred for further tests. [ABSTRACT FROM AUTHOR]

Published
2022
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43. Sleep and Anabolic/Catabolic Hormonal Profile in Sedentary Middle-Aged Adults: The FIT-AGEING Study.

Author

Mochón-Benguigui, Sol, Carneiro-Barrera, Almudena, Dote-Montero, Manuel, Castillo, Manuel J., and Amaro-Gahete, Francisco J.

Subjects
MIDDLE-aged persons, SLEEP quality, SLEEP interruptions, SEX hormones, SLEEP hygiene, SLEEP, SLEEP deprivation
Abstract

Sleep quality plays an important role in the modulation of several aging markers. This influence could be explained by aging-induced hormonal changes. Indeed, poor sleep quality has been associated with the development of several endocrine-related health complications. This study examined the relationship of both subjective and objective sleep quantity and quality, with basal levels of selected plasma anabolic and catabolic hormones in sedentary middle-aged adults. A total of 74 volunteers (52.7% women; aged 53.7 ± 5.1) were recruited for this study. Subjective sleep quality was assessed by the Pittsburgh Sleep Quality Index (PSQI; higher scores indicate worse sleep quality), and objective sleep quality parameters (total sleep time [TST], wake after sleep onset [WASO], and sleep efficiency [SE]) were measured using a wrist-worn accelerometer. Basal levels of plasma dehydroepiandrosterone sulphate (DHEAS), total testosterone, sex hormone binding globulin (SHBG), somatotropin, and cortisol levels, were determined. Free testosterone was calculated from the total testosterone and SHBG levels. No associations of global PSQI score, TST, WASO, and SE with DHEAS, free testosterone, and somatotropin plasma levels were found, neither in men nor in women (all p ≥ 0.05). Global PSQI score was inversely related to cortisol plasma levels in women (p = 0.043). WASO was positively associated with cortisol plasma levels, while SE was negatively associated with cortisol plasma levels in women (all p ≤ 0.027). Sleep quality is not related to levels of plasma anabolic hormones, but to levels of catabolic hormones, in sedentary middle-aged adults. Therefore, these results suggest that potential changes in aging biomarkers associated with sleep disturbances, could be mediated by age-related changes in the catabolic endocrine system. [ABSTRACT FROM AUTHOR]

Published
2022
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46. Physical Activity Is Associated with Attention Capacity in Adolescents

Author

Vanhelst, Jérémy, Béghin, Laurent, Duhamel, Alain, Manios, Yannis, Molnar, Denes, De Henauw, Sefaan, Moreno, Luis A., Ortega, Francisco B., Sjöström, Michael, Widhalm, Kurt, Gottrand, Frédéric, De Henauw, Stefaan, González-Gross, Marcela, Gilbert, Chantal, Kafatos, Anthony, Libersa, Christian, Sánchez, Jackie, Kersting, Mathilde, Sjöstrom, Michael, Molnár, Dénes, Dallongeville, Jean, Hall, Gunnar, Maes, Lea, Scalfi, Luca, Meléndez, Pilar, Fleta, Jesús, Casajús, José A., Rodríguez, Gerardo, Tomás, Concepción, Mesana, María I., Vicente-Rodríguez, Germán, Villarroya, Adoración, Gil, Carlos M., Ara, Ignacio, Revenga, Juan, Lachen, Carmen, Alvira, Juan Fernández, Bueno, Gloria, Lázaro, Aurora, Bueno, Olga, León, Juan F., Garagorri, Jesús M, Bueno, Manuel, Rey López, Juan Pablo, Iglesia, Iris, Velasco, Paula, Bel, Silvia, Marcos, Ascensión, Wärnberg, Julia, Nova, Esther, Gómez, Sonia, Díaz, Esperanza Ligia, Romeo, Javier, Veses, Ana, Puertollano, Mari Angeles, Zapatera, Belén, Pozo, Tamara, Martínez, David, Beghin, Laurent, Iliescu, Catalina, Von Berlepsch, Juliana, Sichert-Hellert, Wolfgang, Koeppen, Ellen, Molnar, Dénes, Erhardt, Eva, Csernus, Katalin, Török, Katalin, Bokor, Szilvia, Angster, Miklós, Nagy, Enikö, Kovács, Orsolya, Repásy, Judit, Kafatos, Anthony, Codrington, Caroline, Plada, María, Papadaki, Angeliki, Sarri, Katerina, Viskadourou, Anna, Hatzis, Christos, Kiriakakis, Michael, Tsibinos, George, Vardavas, Constantine, Sbokos, Manolis, Protoyeraki, Eva, Fasoulaki, Maria, Stehle, Peter, Pietrzik, Klaus, Breidenassel, Christina, Spinneker, Andre, Al-Tahan, Jasmin, Segoviano, Miriam, Berchtold, Anke, Bierschbach, Christine, Blatzheim, Erika, Schuch, Adelheid, Pickert, Petra, Castillo, Manuel J., Gutiérrez, Ángel, Ruiz, Jonatan R., Artero, Enrique G., España-Romero, Vanesa, Jiménez-Pavón, David, Chillón, Palma, Cuenca-García, Magdalena, Arcella, Davide, Azzini, Elena, Barrison, Emma, Bevilacqua, Noemi, Buonocore, Pasquale, Catasta, Giovina, Censi, Laura, Ciarapica, Donatella, DʼAcapito, Paola, Ferrari, Marika, Galfo, Myriam, Le Donne, Cinzia, Leclercq, Catherine, Maiani, Giuseppe, Mauro, Beatrice, Mistura, Lorenza, Pasquali, Antonella, Piccinelli, Raffaela, Polito, Angela, Spada, Raffaella, Sette, Stefania, Zaccaria, Maria, Vitaglione, Paola, Montagnese, Concetta, De Bourdeaudhuij, Ilse, De Vriendt, Tineke, Matthys, Christophe, Vereecken, Carine, de Maeyer, Mieke, Ottevaere, Charlene, Huybrechts, Inge, Phillipp, Katharina, Dietrich, Sabine, Kubelka, Birgit, Boriss-Riedl, Marion, Manios, Yannis, Grammatikaki, Eva, Bouloubasi, Zoi, Cook, Tina Louisa, Eleutheriou, Sofia, Consta, Orsalia, Moschonis, George, Katsaroli, Ioanna, Kraniou, George, Papoutsou, Stalo, Keke, Despoina, Petraki, Ioanna, Bellou, Elena, Tanagra, Sofia, Kallianoti, Kostalenia, Argyropoulou, Dionysia, Kondaki, Katerina, Tsikrika, Stamatoula, Karaiskos, Christos, Meirhaeghe, Aline, Bergman, Patrick, Hagströmer, María, Hallström, Lena, Hallberg, Mårten, Poortvliet, Eric, Rizzo, Nico, Beckman, Linda, Wennlöf, Anita Hurtig, Patterson, Emma, Kwak, Lydia, Cernerud, Lars, Tillgren, Per, Sörensen, Stefaan, Sánchez-Molero, Jackie, Picó, Elena, Navarro, Maite, Viadel, Blanca, Carreres, José Enrique, Merino, Gema, Sanjuán, Rosa, Lorente, María, Sánchez, María José, Castelló, Sara, Thomas, Sarah, Allchurch, Elaine, Burguess, Peter, Astrom, Annika, Sverkén, Anna, Broberg, Agneta, Masson, Annick, Lehoux, Claire, Brabant, Pascal, Pate, Philippe, Fontaine, Laurence, Sebok, Andras, Kuti, Tunde, Hegyi, Adrienn, Maldonado, Cristina, Llorente, Ana, García, Emilio, von Fircks, Holger, Hallberg, Marianne Lilja, Messerer, Maria, Larsson, Mats, Fredriksson, Helena, Adamsson, Viola, Börjesson, Ingmar, Fernández, Laura, Smillie, Laura, Wills, Josephine, Meléndez, Agustín, Benito, Pedro J., Calderón, Javier, Valtueña, Jara, Navarro, Paloma, Urzanqui, Alejandro, Albers, Ulrike, Pedrero, Raquel, and Gómez Lorente, Juan José

Published
2016
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