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211 results on '"Carmody, Thomas J."'

5. Neural substrates of emotional conflict with anxiety in major depressive disorder: Findings from the Establishing Moderators and biosignatures of Antidepressant Response in Clinical Care (EMBARC) randomized controlled trial

Author

Trombello, Joseph M., Cooper, Crystal M., Fatt, Cherise Chin, Grannemann, Bruce D., Carmody, Thomas J., Jha, Manish K., Mayes, Taryn L., Greer, Tracy L., Yezhuvath, Uma, Aslan, Sina, Pizzagalli, Diego A., Weissman, Myrna M., Webb, Christian A., Dillon, Daniel G., McGrath, Patrick J., Fava, Maurizio, Parsey, Ramin V., McInnis, Melvin G., Etkin, Amit, and Trivedi, Madhukar H.

Published
2022
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9. Anxiety and anhedonia in depression: Associations with neuroticism and cognitive control

Author

Liao, Allen, Walker, Robrina, Carmody, Thomas J., Cooper, Crystal, Shaw, Meredith A., Grannemann, Bruce D., Adams, Phil, Bruder, Gerard E., McInnis, Melvin G., Webb, Christian A., Dillon, Daniel G., Pizzagalli, Diego A., Phillips, Mary L., Kurian, Benji T., Fava, Maurizio, Parsey, Ramin V., McGrath, Patrick J., Weissman, Myrna M., and Trivedi, Madhukar H.

Published
2019
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11. Characterizing anxiety subtypes and the relationship to behavioral phenotyping in major depression: Results from the EMBARC study

Author

Trombello, Joseph M., Pizzagalli, Diego A., Weissman, Myrna M., Grannemann, Bruce D., Cooper, Crystal M., Greer, Tracy L., Malchow, Ashley L., Jha, Manish K., Carmody, Thomas J., Kurian, Benji T., Webb, Christian A., Dillon, Daniel G., McGrath, Patrick J., Bruder, Gerard, Fava, Maurizio, Parsey, Ramin V., McInnis, Melvin G., Adams, Phil, and Trivedi, Madhukar H.

Published
2018
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13. Establishing moderators and biosignatures of antidepressant response in clinical care (EMBARC): Rationale and design

Author

Trivedi, Madhukar H., McGrath, Patrick J., Fava, Maurizio, Parsey, Ramin V., Kurian, Benji T., Phillips, Mary L., Oquendo, Maria A., Bruder, Gerard, Pizzagalli, Diego, Toups, Marisa, Cooper, Crystal, Adams, Phil, Weyandt, Sarah, Morris, David W., Grannemann, Bruce D., Ogden, R. Todd, Buckner, Randy, McInnis, Melvin, Kraemer, Helena C., Petkova, Eva, Carmody, Thomas J., and Weissman, Myrna M.

Published
2016
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16. A Psychometric Evaluation of the CDRS and MADRS in Assessing Depressive Symptoms in Children

Author

Jain, Shailesh, Carmody, Thomas J., and Trivedi, Madhukar H.

Abstract

Objective: This study compared the psychometric properties of the Children's Depression Rating Scale-Revised (CDRS-R) and the Montgomery-Asberg Depression Rating Scale (MADRS) in children with major depressive disorder. Method: Children (N = 96; ages 8 to 11 years inclusive) with nonpsychotic major depressive disorder were enrolled. Participants were part of a multisite, outpatient, randomized, placebo-controlled, 9-week trial of fluoxetine (10 mg/day for the first week and 20 mg/day thereafter). The CDRS-R and MADRS were completed based on clinician interviews with both parents and children. Classic test theory and item response theory analyses were conducted. Results: The MADRS and CDRS-R total scores were correlated at baseline (r = 0.51) and at study exit (r = 0.85). Cronbach's [alpha] was 0.86 (CDRS-R) and 0.82 (MADRS) at exit. The effect sizes for change from baseline to exit between the fluoxetine and placebo groups were 0.78 (CDRS-R) and 0.61 (MADRS). There was agreement between the CDRS-R and MADRS in the declaration of treatment response (50% improvement from baseline to exit) in 84.2% of children. Test information function favored the CDRS-R. Conclusions: The CDRS-R showed greater effect size for differentiating drug and placebo and better test information than the MADRS in this study of depressed children. (Contains 1 figure and 6 tables.)

Published
2007

17. The Concise Health Risk Tracking ‐ Self‐Report (CHRT‐SR)—A measure of suicidal risk: Performance in adolescent outpatients.

Author

Nandy, Karabi, Rush, A. John, Carmody, Thomas J., Kulikova, Alexandra, Mayes, Taryn L., Emslie, Graham, and Trivedi, Madhukar H.

Subjects
CLASSICAL test theory, ITEM response theory, SELF-evaluation, PSYCHOMETRICS, CONFIRMATORY factor analysis
Abstract

Objectives: The Concise Health Risk Tracking Self‐Report (CHRT‐SR) assesses the risk of suicidal behavior. We report its psychometric properties in a representative sample of adolescent outpatients. Methods: A sample (n = 657) of adolescents (<18 years of age) in primary or psychiatric care completed the 14‐item version of CHRT‐SR at both baseline and within 3 months. To identify an optimal brief solution for the scale, we evaluated the factor structure of CHRT‐SR using multigroup confirmatory factor analysis, and testing measurement invariance across age and gender. The item response theory and classical test theory characteristics of the optimal solution were evaluated. Concurrent validity (both cross‐sectional and as a change measure over time) of the optimal solution was assessed by comparing it to another suicide measure. Results: Confirmatory factor analysis identified the 9‐item CHRT‐SR (CHRT‐SR9) as the optimal solution. Classical test theory and item response theory indicated excellent fit. Concurrent validity analyses revealed that it can measure both improvement/worsening of suicidality over time. Conclusion: The CHRT‐SR9 is a brief self‐report with excellent psychometric properties in a sample of adolescents that is sensitive to changes in suicidality over time. Its performance in other populations and ability to predict future suicidal events deserves study. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Improvements in psychosocial functioning and health-related quality of life following exercise augmentation in patients with treatment response but non-remitted major depressive disorder: Results from the TREAD study

Author

Greer, Tracy L., Trombello, Joseph M., Rethorst, Chad D., Carmody, Thomas J., Jha, Manish K., Liao, Allen, Grannemann, Bruce D., Chambliss, Heather O., Church, Timothy S., and Trivedi, Madhukar H.

Subjects
Adult, Male, Depressive Disorder, Major, Adolescent, Middle Aged, Combined Modality Therapy, Article, Antidepressive Agents, Exercise Therapy, Depressive Disorder, Treatment-Resistant, Young Adult, Quality of Life, Humans, Female, Social Adjustment, Aged, Follow-Up Studies
Abstract

Functional impairments often remain despite symptomatic improvement with antidepressant treatment, supporting the need for novel treatment approaches. The present study examined the extent to which exercise augmentation improved several domains of psychosocial functioning and quality of life (QoL) among depressed participants.Data were collected from 122 partial responders to antidepressant medication. Participants were randomized to either high- (16 kcal/kg of weight/week [KKW]) or low-dose (4-KKW) exercise. Participants completed a combination of supervised and home-based exercise for 12 weeks. The Short-Form Health Survey, Work and Social Adjustment Scale, Social Adjustment Scale, Quality of Life Enjoyment and Satisfaction Questionnaire, and Satisfaction with Life Scale were collected at 6 and 12 weeks. Participants with data for at least one of the two follow-up time points (n = 106) were analyzed using a linear mixed model to assess change from baseline within groups and the difference between groups for each psychosocial outcome measure. All analyses controlled for covariates, including baseline depressive symptomatology.Participants experienced significant improvements in functioning across tested domains, and generally fell within a healthy range of functioning on all measures at Weeks 6 and 12. Although no differences were found between exercise groups, improvements were observed across a variety of psychosocial and QoL domains, even in the low-dose exercise group.These findings support exercise augmentation of antidepressant treatment as a viable intervention for treatment-resistant depression to improve function in addition to symptoms.

Published
2016

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