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An innovative electroanalytical method has been described for the simultaneous determination of amlodipine besylate (AML) and atorvastatin calcium (ATOR) using the square-wave voltammetry and an anodically pretreated boron-doped diamond electrode. Two very well-resolved and reproducible oxidation peaks for AML and ATOR were obtained in Britton-Robinson buffer solution (pH 4.0). Under the optimum analytical experimental conditions, the method exhibits linear responses to AML and ATOR in the concentration ranges 2.0 – 28 and 1.0 – 50 µmol L−1, respectively, with detection limits of 0.028 and 0.38 µmol L−1, respectively. The proposed novel method was applied in the simultaneous determination of AML and ATOR content in combined dosage forms and the accuracy was attested by means of comparison with those data obtained from high performance liquid chromatography at a 95% confidence level (paired t-test). DOI: http://dx.doi.org/10.17807/orbital.v9i4.973

A simple procedure is described for the determination of scopolamine by square-wave voltammetry using a cathodically pretreated boron-doped diamond electrode. Cyclic voltammetry studies indicate that the oxidation of scopolamine is irreversible at a peak potential of 1.59 V (vs. Ag/AgCl (3.0 mol L-1 KCl)) in a 0.50 mol L-1 sulfuric acid solution. Under optimized conditions, the analytical curve obtained was linear (r = 0.9996) for the scopolamine concentration range of 1.0 to 110 µmol L-1, with a detection limit of 0.84 µmol L-1. The method was successfully applied to the determination of scopolamine in pharmaceutical formulations with minimum sample preparation.

The simultaneous voltammetric determination of antihypertensive drugs amlodipine besylate (AML) and atenolol (ATN) using a cathodically pretreated boron-doped diamond electrode (CP-BDDE) is reported for the first time. The anodic peak potentials of AML and ATN at a CP-BDDE were found to be 0.727 and 1.32 V (vs. Ag/AgCl (3.0 mol L-1 KCl)) in phosphate buffer (pH 7.0), respectively, by cyclic voltammetry. It was observed that the CP-BDDE possesses improved performance for the simultaneous determination of AML and ATN when compared to other carbon-based electrodes in these conditions. Using square-wave voltammetric technique, the obtained analytical curves were linear in the concentration range from 2.9-33 µmol L-1 for AML and 9.8-190 µmol L-1 for ATN, with limits of detection of 0.17 and 0.22 µmol L-1, respectively. The proposed method was successfully applied to the simultaneous determination of AML and ATN in pharmaceutical samples.