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2. May 2023 Critical Care Case of the Month: Not a Humerus Case

Author

Carli S. Ogle DO, Billie Bixby MD, and Janet Campion MD

Subjects
osteogenesis imperfecta, scoliosis, pneumonia, ct scan, bone density, intubation, endotracheal intubation, hyperthermia, fracture risk, fiberoptic intubation, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9, Diseases of the respiratory system, RC705-779
Abstract

No abstract available. Article truncated after 150 words. History of Present Illness: A 57-year-old woman with history of bone disease presented with a 3-day history of cough with thick yellow phlegm and progressive shortness of breath. No fever, chest pain or abdominal pain was noted. In the emergency department, she had SpO2 of 55% on room air, and then 90% on 15L NRB. Past Medical History/Social History/Family History • Bone disease since birth • Asthma • Severe scoliosis • Gastrointestinal reflux disease • Cholecystectomy • Spinal growth rods • Lives in adult care home, supportive family • No smoking or alcohol use • No illicit drug use • There is no family history of any bone disease Home Medications: • Albuterol MDI PRN • Alendronate 10mg daily • Budesonide nebulizer BID • Calcium carbonate BID • MVI daily • Lisinopril 10mg daily • Loratadine 10mg daily • Metformin 500mg BID • Metoprolol 12.5mg BID • Montelukast 10mg daily • Naprosyn PRN • Omeprazole 20mg daily • Simvastatin 10mg daily • Tizanidine PRN • Vitamin D 2000 IU daily Allergies: Cefazolin, PCN, Sulfa …

Published
2023
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7. Numerical implications of including drifts in SOLPS-ITER simulations of EAST.

Author

Boeyaert, D., Carli, S., Dekeyser, W., Wiesen, S., and Baelmans, M.

Subjects
*PLASMA potentials, *DEUTERIUM
Abstract

The inclusion of drifts in plasma edge codes like SOLPS-ITER is required to match simulation data with experimental profiles. However, this remains numerically challenging. In this paper, the effect of some numerical factors on the final plasma solution is investigated. This study is performed on three EAST simulations in the upper single null configuration: an attached purely deuterium case, an attached case with limited Ne-seeding, and a detached Ne-seeded case. The effects of the anomalous conductivity and anomalous thermo-electric coefficient on the plasma potential are investigated. Next, the effect of the employed grids is shown. In order to investigate these effects, accurate drift simulations are needed. Therefore, the employed time step and numerical parameters are discussed for the three studied simulations. For all presented simulations, it is verified that the restriction of the grid to the first flux surface tangent to the main chamber wall is sufficient within the context of non-extended simulations. This means that the main power dissipation takes place inside the simulated domain, and only a small fraction of the power is leaving the B2.5 grid through the grid boundary closest to the first wall. Finally, the effect of drifts on the asymmetry between the inner and outer target for EAST simulations is demonstrated. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Overview of the TCV tokamak experimental programme

Author

Reimerdes, H. Agostini, M. Alessi, E. Alberti, S. and Andrebe, Y. Arnichand, H. Balbin, J. Bagnato, F. and Baquero-Ruiz, M. Bernert, M. Bin, W. Blanchard, P. and Blanken, T. C. Boedo, J. A. Brida, D. Brunner, S. Bogar, C. Bogar, O. Bolzonella, T. Bombarda, F. Bouquey, F. and Bowman, C. Brunetti, D. Buermans, J. Bufferand, H. and Calacci, L. Camenen, Y. Carli, S. Carnevale, D. and Carpanese, F. Causa, F. Cavalier, J. Cavedon, M. and Cazabonne, J. A. Cerovsky, J. Chandra, R. Jayalekshmi, A. Chandrarajan Chellai, O. Chmielewski, P. Choi, D. and Ciraolo, G. Classen, I. G. J. Coda, S. Colandrea, C. Dal Molin, A. David, P. de Baar, M. R. Decker, J. Dekeyser, W. de Oliveira, H. Douai, D. Dreval, M. Dunne, M. G. and Duval, B. P. Elmore, S. Embreus, O. Eriksson, F. and Faitsch, M. Falchetto, G. Farnik, M. Fasoli, A. and Fedorczak, N. Felici, F. Fevrier, O. Ficker, O. Fil, A. and Fontana, M. Fransson, E. Frassinetti, L. Furno, I and Gahle, D. S. Galassi, D. Galazka, K. Galperti, C. and Garavaglia, S. Garcia-Munoz, M. Geiger, B. Giacomin, M. and Giruzzi, G. Gobbin, M. Golfinopoulos, T. Goodman, T. and Gorno, S. Granucci, G. Graves, J. P. Griener, M. Gruca, M. Gyergyek, T. Haelterman, R. Hakola, A. Han, W. and Happel, T. Harrer, G. Harrison, J. R. Henderson, S. and Hogeweij, G. M. D. Hogge, J-P Hoppe, M. Horacek, J. and Huang, Z. Iantchenko, A. Innocente, P. Bjork, K. Insulander and Ionita-Schrittweiser, C. Isliker, H. Jardin, A. Jaspers, R. J. E. Karimov, R. Karpushov, A. N. Kazakov, Y. Komm, M. Kong, M. Kovacic, J. Krutkin, O. Kudlacek, O. and Kumar, U. Kwiatkowski, R. Labit, B. Laguardia, L. and Lammers, J. T. Laribi, E. Laszynska, E. Lazaros, A. and Linder, O. Linehan, B. Lipschultz, B. Llobet, X. Loizu, J. Lunt, T. Macusova, E. Marandet, Y. Maraschek, M. and Marceca, G. Marchetto, C. Marchioni, S. Marmar, E. S. and Martin, Y. Martinelli, L. Matos, F. Maurizio, R. and Mayoral, M-L Mazon, D. Menkovski, V Merle, A. Merlo, G. and Meyer, H. Mikszuta-Michalik, K. Cabrera, P. A. Molina and Morales, J. Moret, J-M Moro, A. Moulton, D. Muhammed, H. and Myatra, O. Mykytchuk, D. Napoli, F. Nem, R. D. and Nielsen, A. H. Nocente, M. Nowak, S. Offeddu, N. Olsen, J. Orsitto, F. P. Pan, O. Papp, G. Pau, A. Perek, A. and Pesamosca, F. Peysson, Y. Pigatto, L. Piron, C. and Poradzinski, M. Porte, L. Putterich, T. Rabinski, M. and Raj, H. Rasmussen, J. J. Ratta, G. A. Ravensbergen, T. and Ricci, D. Ricci, P. Rispoli, N. Riva, F. and Rivero-Rodriguez, J. F. Salewski, M. Sauter, O. Schmidt, B. S. Schrittweiser, R. Sharapov, S. Sheikh, U. A. Sieglin, B. Silva, M. Smolders, A. Snicker, A. Sozzi, C. and Spolaore, M. Stagni, A. Stipani, L. Sun, G. Tala, T. and Tamain, P. Tanaka, K. Biwole, A. Tema Terranova, D. and Terry, J. L. Testa, D. Theiler, C. Thornton, A. Thrysoe, A. Torreblanca, H. Tsui, C. K. Vaccaro, D. Vallar, M. and van Berkel, M. Van Eester, D. van Kampen, R. J. R. Van Mulders, S. Verhaegh, K. Verhaeghe, T. Vianello, N. and Villone, F. Viezzer, E. Vincent, B. Voitsekhovitch, I and Vu, N. M. T. Walkden, N. Wauters, T. Weisen, H. Wendler, N. Wensing, M. Widmer, F. Wiesen, S. Wischmeier, M. and Wijkamp, T. A. Wunderlich, D. Wuthrich, C. Yanovskiy, V and Zebrowski, J. EUROfusion MST1 Team

Abstract

The tokamak a configuration variable (TCV) continues to leverage its unique shaping capabilities, flexible heating systems and modern control system to address critical issues in preparation for ITER and a fusion power plant. For the 2019-20 campaign its configurational flexibility has been enhanced with the installation of removable divertor gas baffles, its diagnostic capabilities with an extensive set of upgrades and its heating systems with new dual frequency gyrotrons. The gas baffles reduce coupling between the divertor and the main chamber and allow for detailed investigations on the role of fuelling in general and, together with upgraded boundary diagnostics, test divertor and edge models in particular. The increased heating capabilities broaden the operational regime to include T (e)/T (i) similar to 1 and have stimulated refocussing studies from L-mode to H-mode across a range of research topics. ITER baseline parameters were reached in type-I ELMy H-modes and alternative regimes with `small' (or no) ELMs explored. Most prominently, negative triangularity was investigated in detail and confirmed as an attractive scenario with H-mode level core confinement but an L-mode edge. Emphasis was also placed on control, where an increased number of observers, actuators and control solutions became available and are now integrated into a generic control framework as will be needed in future devices. The quantity and quality of results of the 2019-20 TCV campaign are a testament to its successful integration within the European research effort alongside a vibrant domestic programme and international collaborations.

Published
2022

16. The neutrophil/lymphocyte ratio as a prognostic factor in COVID-19 patients: a case-control study

Author

LA TORRE, Giuseppe, Marte, M., Massetti, A. P., Carli, S. M., Romano, F., Mastroianni, C. M., Minorenti, M., Alessandri, F., Ajassa, C., Fusconi, M., DE VINCENTIIS, M., DE MEO, D., Villani, C., Cardi, M., Pugliese, F., Aronica, Raissa, Mauro, Vera, Casali, Elena, Di Bari Silvia, Gavaruzzi, Francesca, Romani, FRANCESCO EUGENIO, Fassari, Alessia, Filippi, Valeria, Ambrogio, Curtolo, Piero Giuseppe Meliante, and Roger, Altomari

Subjects
Male, Neutrophils, Critical Illness, COVID-19, Middle Aged, Prognosis, Severity of Illness Index, Intensive Care Units, Leukocyte Count, Logistic Models, Italy, ROC Curve, Risk Factors, Case-Control Studies, Humans, Female, neutrophil to lymphocyte ratio, case-control, Lymphocytes, Biomarkers, Aged, Retrospective Studies
Abstract

SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) has been identified in China as responsible for viral pneumonia, now called COVID-19 (Coronavirus Disease 2019). Patients infected can develop common symptoms like cough and sore throat, and, in severe cases, acute respiratory syndrome and even death. To optimize the available resources, it is necessary to identify in advance the subjects that will develop a more serious illness, therefore requiring intensive care.The neutrophil / lymphocyte ratio (NLR) parameter, resulting from the blood count, could be a significant marker for the diagnosis and management of risk stratification.A retrospective, single-center case-control observational study was conducted. The differential cell count of leukocytes, the NLR and the clinical course of patients hospitalized in intensive care with COVID-19 were analyzed, comparing them with other patients (COVID-19 and non-COVID-19) and healthy individuals selected among workers of the Teaching Hospital Policlinico Umberto I in Rome.370 patients (145 cases and 225 controls) were included in the case-control study, 211 males (57%) and 159 females (43%). The average age of the population was 63 years (SD 16.35). In the group of cases, out of 145 patients, 57 deaths and 88 survivors were recorded, with a lethality rate of 39.3%. The group of cases has an NLR of 7.83 (SD = 8.07), a much higher value than the control group where an NLR of 2.58 was recorded (SD = 1.93) (p0.001). The Neutrophils / Lymphocytes ratio may prove to be a diagnostic factor for COVID-19, an NLR3.68 revealed an OR 10.84 (95% CI = 6.47 - 18.13) (p0.005).The value of NLR considered together with the age variable allows a risk stratification and allows the development of diagnostic and treatment protocols for patients affected by COVID-19. A high neutrophil to lymphocyte ratio suggests worse survival. Risk stratification and management help alleviate the shortage of medical resources and reduce the mortality of critically ill patients.

Published
2022

24. The neutrophil/lymphocyte ratio as a prognostic factor in COVID-19 patients: a case-control study.

Author

LA TORRE, G., MARTE, M., MASSETTI, A. P., CARLI, S. M., ROMANO, F., MASTROIANNI, C. M., MINORENTI, M., ALESSANDRI, F., AJASSA, C., FUSCONI, M., DE VINCENTIIS, M., DE MEO, D., VILLANI, C., CARDI, M., and PUGLIESE, F.

Abstract

OBJECTIVE: SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) has been identified in China as responsible for viral pneumonia, now called COVID-19 (Coronavirus Disease 2019). Patients infected can develop common symptoms like cough and sore throat, and, in severe cases, acute respiratory syndrome and even death. To optimize the available resources, it is necessary to identify in advance the subjects that will develop a more serious illness, therefore requiring intensive care. The neutrophil / lymphocyte ratio (NLR) parameter, resulting from the blood count, could be a significant marker for the diagnosis and management of risk stratification. PATIENTS AND METHODS: A retrospective, single-center case-control observational study was conducted. The differential cell count of leukocytes, the NLR and the clinical course of patients hospitalized in intensive care with COVID-19 were analyzed, comparing them with other patients (COVID-19 and non-COVID-19) and healthy individuals selected among workers of the Teaching Hospital Policlinico Umberto I in Rome. RESULTS: 370 patients (145 cases and 225 controls) were included in the case-control study, 211 males (57%) and 159 females (43%). The average age of the population was 63 years (SD 16.35). In the group of cases, out of 145 patients, 57 deaths and 88 survivors were recorded, with a lethality rate of 39.3%. The group of cases has an NLR of 7.83 (SD = 8.07), a much higher value than the control group where an NLR of 2.58 was recorded (SD = 1.93) (p <0.001). The Neutrophils / Lymphocytes ratio may prove to be a diagnostic factor for COVID-19, an NLR> 3.68 revealed an OR 10.84 (95% CI = 6.47 - 18.13) (p <0.005). CONCLUSIONS: The value of NLR considered together with the age variable allows a risk stratification and allows the development of diagnostic and treatment protocols for patients affected by COVID-19. A high neutrophil to lymphocyte ratio suggests worse survival. Risk stratification and management help alleviate the shortage of medical resources and reduce the mortality of critically ill patients. [ABSTRACT FROM AUTHOR]

Published
2022

32. Non‐lactose‐fermenting uropathogenic Escherichia coli from dogs: virulence profile characterization.

Author

Siqueira, F.M., De Carli, S., Lopes, C.E., Machado, L., Vieira, T.R., Pöppl, Á.G., Cardoso, M.R.I., and Zaha, A.

Subjects
*ESCHERICHIA coli, *MULTIDRUG resistance, *EXTRACELLULAR matrix, *BIOFILMS, *DRUG resistance in bacteria
Abstract

Non‐lactose‐fermenting Escherichia coli (NLFEC) has a few descriptive studies restricted to human infections. In the present study, isolates of NLFEC obtained from urine samples of dogs with hyperadrenocorticism were characterized regarding their virulence ability, biofilm formation capacity and antimicrobial susceptibility profile. Escherichia coli lactose‐fermenting strains from urinary infection in dogs with the same conditions were analysed to provide comparisons. The non‐lactose‐fermenting E. coli strains were classified as belonging to clade I E. coli, whereas the lactose‐fermenting strains were classified in phylogroup B2. All strains presented virulence markers to adhesion, iron acquisition, toxins, colicin and cytotoxin production, and biofilm regulation. Components of the extracellular matrix in addition to the in vitro biofilm formation ability were observed in the strains. Multidrug resistance (MDR) profiles were observed by in vitro susceptibility tests to all NLFEC strains. In summary, non‐lactose‐fermenting uropathogenic E. coli from dogs behaves similar to lactose‐fermenting E. coli, exhibiting MDR profile, and pathogenic potential of promote animal infections. [ABSTRACT FROM AUTHOR]

Published
2021
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34. Molecular Detection and Characterization of Salmonella Gallinarum From Poultry Farms in Brazil.

Author

Zanetti, N S, Carli, S De, Souza, M N, Lehmann, F K M, Kipper, D, Dias, K K R, Fonseca, A S K, Lunge, V R, and Ikuta, N

Subjects
*POULTRY farms, *SALMONELLA detection, *CHICKEN diseases, *ENVIRONMENTAL sampling, *TYPHOID fever, *POULTRY
Abstract

Salmonella is a bacterium usually associated with mild gastroenteritis in chickens, but strains of the serotype Gallinarum can result in 2 severe systemic chicken diseases: fowl typhoid (by biovar Gallinarum) and pullorum disease (by biovar Pullorum). These diseases can be controlled by immunization with a specific vaccine (SG 9R). The aim of this study was to characterize recent Salmonella Gallinarum isolates by molecular analyses, as well as detect field and vaccine strains in clinical and environmental samples from poultry flocks. Field isolates of S. Gallinarum (n = 18) and other serotypes (n = 117) were obtained from Brazilian poultry farms between 2012 and 2015. In addition, clinical and environmental samples of poultry flocks (vaccinated or not) with fowl typhoid were obtained in a 3-year period (2013 to 2015). The results demonstrated that specific PCR targeted on speC and glgC genes and PCR-restriction fragment length polymorphisms based on fliC and sefA genes detected all the 18 isolates, 10 identified as field isolates of biovar Gallinarum and 8 as biovar Pullorum. All isolates of other serotypes presented negative results. In addition, PCR tests were performed directly from the pre-enrichment broth of the bacteriological procedures. Vaccine SG 9R and field S. Gallinarum strains were detected in samples with (n = 19) and without (n = 59) vaccination. These results demonstrate the use of PCR tests for detection of S. Gallinarum in clinical and environmental Brazilian poultry samples. [ABSTRACT FROM AUTHOR]

Published
2019
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36. Clinical features and follow-up in patients with 22q11.2 deletion syndrome

Author

Cancrini, C, Puliafito, P, Digilio, M, Soresina, A, Martino, S, Rondelli, R, Consolini, R, Ruga, E, Cardinale, F, Finocchi, A, Romiti, Ml, Martire, B, Bacchetta, R, Albano, V, Carotti, A, Specchia, F, Montin, D, Cirillo, E, Cocchi, G, Trizzino, A, Bossi, G, Milanesi, O, Azzari, C, Corsello, G, Pignata, C, Aiuti, A, Pietrogrande, M, Marino, B, Ugazio, A, Plebani, A, Rossi, P, Pierani, P, Gabrielli, A, Danieli, M, De Mattia, D, Sisto, C, Dammacco, F, Ranieri, G, Pession, A, Ricci, G, Minelli, P, Lougaris, V, Badolato, R, Cattaneo, R, Airò, P, Mura, R, Cossu, F, Del Giacco, S, Manconi, P, Consarino, C, Dello Russo, A, Miniero, R, Anastasio, E, Marino, S, Russo, G, Paganelli, R, Sperlì, D, Carpino, L, Aricò, M, Gambineri, E, Lippi, F, Canessa, C, Maggi, E, Romagnani, S, Matucci, A, Vultaggio, A, Gattorno, M, Castagnola, E, Nigro, G, Presta, G, Civino, A, Buzi, F, Gambaretto, G, Fasoli, S, Salpietro, C, Gallizzi, R, Dellepiane, R, Panisi, C, Fabio, G, Carrabba, M, Roncarolo, M, Biondi, A, Vallinoto, C, Poggi, V, Menna, G, Di Nardo, R, Sottile, R, Marone, G, Spadaro, G, Carli, M, Basso, G, Putti, C, Semenzato, G, Agostini, C, D'Angelo, P, Izzi, G, Bertolini, P, Zecca, M, Marseglia, G, Maccario, R, Felici, L, Favre, C, Vecchi, V, Sacchini, P, Rinaldi, G, Livadiotti, S, Simonetti, A, Stabile, A, Duse, M, Iacobini, M, Quinti, I, Fiorilli, M, Moschese, V, Cecere, F, D'Ambrosio, A, De Zan, G, Strafella, S, Tamaro, P, Rabusin, M, Tommasini, A, Tovo, P, De Carli, M, De Carli, S, Nespoli, L, Marinoni, M, Porcellini, A, Lunardi, C, Patuzzo, G, Boner, A, Degani, D, Cancrini, C, Puliafito, P, Digilio, Mc, Soresina, A, Martino, S, Rondelli, R, Consolini, R, Ruga, Em, Cardinale, F, Finocchi, A, Romiti, Ml, Martire, B, Bacchetta, R, Albano, V, Carotti, A, Specchia, F, Montin, D, Cirillo, E, Cocchi, G, Trizzino, A, Bossi, G, Milanesi, O, Azzari, C, Corsello, G, Pignata, C, Aiuti, Alessandro, Pietrogrande, Mc, Marino, B, Ugazio, Ag, Plebani, A, Rossi, P., Cancrini, Caterina, Puliafito, Pamela, Digilio, Maria Cristina, Soresina, Annarosa, Martino, Silvana, Rondelli, Roberto, Consolini, Rita, Ruga, Ezia Maria, Cardinale, Fabio, Finocchi, Andrea, Romiti, Maria Luisa, Martire, Baldassarre, Bacchetta, Rosa, Albano, Veronica, Carotti, Adriano, Specchia, Fernando, Montin, Davide, Cirillo, Emilia, Cocchi, Guido, Trizzino, Antonino, Bossi, Grazia, Milanesi, Ornella, Azzari, Chiara, Corsello, Giovanni, Pignata, Claudio, Pietrogrande, Maria Cristina, Marino, Bruno, Ugazio, Alberto Giovanni, Plebani, Alessandro, Rossi, Paolo, Aiuti, A, Rossi, P, Pierani, P, Gabrielli, A, Danieli, Mg, De Mattia, D, Sisto, C, Dammacco, F, Ranieri, G, Pession, A, Ricci, G, Minelli, P, Lougaris, V, Badolato, R, Cattaneo, R, Airò, P, Mura, Rm, Cossu, F, Del Giacco, S, Manconi, Pe, Consarino, C, Dello Russo, Am, Miniero, R, Anastasio, E, Marino, S, Russo, G, Paganelli, R, Sperlì, D, Carpino, L, Aricò, M, Gambineri, E, Lippi, F, Canessa, C, Maggi, E, Romagnani, S, Matucci, A, Vultaggio, A, Gattorno, M, Castagnola, E, Nigro, G, Presta, G, Civino, A, Buzi, F, Gambaretto, G, Fasoli, S, Salpietro, C, Gallizzi, R, Dellepiane, Rm, Panisi, C, Fabio, G, Carrabba, M, Pietrogrande, M, Roncarolo, Mg, Biondi, A, Vallinoto, C, Poggi, V, Menna, G, Di Nardo, R, Sottile, R, Marone, G, Spadaro, G, Carli, M, Basso, G, Putti, C, Semenzato, G, Agostini, C, D'Angelo, P, Izzi, G, Bertolini, P, Zecca, M, Marseglia, G, Maccario, R, Felici, L, Favre, C, Vecchi, V, Sacchini, P, Rinaldi, G, Livadiotti, S, Simonetti, A, Stabile, A, Duse, M, Iacobini, M, Quinti, I, Fiorilli, M, Moschese, V, Cecere, F, D'Ambrosio, A, De Zan, G, Strafella, S, Tamaro, Paolo, Rabusin, M, Tommasini, A, Tovo, P, De Carli, M, De Carli, S, Nespoli, L, Marinoni, M, Porcellini, A, Lunardi, C, Patuzzo, G, Boner, A, Degani, D., Cancrini, C., Pulisfito, P., Digilio, M. C., Soresina, A., Martino, S., Rondelli, R., Consolini, R., Ruga, E. M., C. a. r. d. i. n. a. l. e., F., Finocchi, A., Romiti, M. L., Martire, B., Bacchetta, R., Albano, V., Carotti, A., Specchia, F., Montin, D., Cocchi, G., Trizzino, A., Bossi, G., Milanesi, O., Azzari, C., Corsello, G., Aiuti, A., Pietrogrande, M. C., Marino, B., Ugazio, A. G., Plebani, A., Digilio, MC, Ruga, EM, Romiti, ML, trizzino, A, Aiuti, Pietrogrande, MC, and Ugazio, AG

Subjects
Male, Pediatrics, 22q11.2 deletion, Delayed Diagnosis, Time Factors, Chromosomes, Human, Pair 22, Developmental Disabilities, digeorge syndrome, Sex Factor, Severity of Illness Index, Retrospective Studie, DiGeorge syndrome, Early Diagnosi, Age Factor, Prospective Studies, Neonatal hypocalcemia, Prospective cohort study, Child, medicine.diagnostic_test, Delayed Diagnosi, Primary immune disorders, Age Factors, del 22q, MIM, Abnormalities, Multiple, Adolescent, Adult, Child, Preschool, DiGeorge Syndrome, Early Diagnosis, Female, Follow-Up Studies, Genetic Testing, Humans, Infant, Infant, Newborn, Monitoring, Physiologic, Retrospective Studies, Risk Assessment, Sex Factors, Young Adult, Disease Progression, Cohort, Abnormalities, Multiple, Pediatrics, Perinatology and Child Health, Human, medicine.medical_specialty, Time Factor, Monitoring, Developmental Disabilitie, Italian Association of Pediatric Haematology and Oncology, Context (language use), Chromosomes, Follow-Up Studie, Severity of illness, medicine, 22q11DS, 22q11.2 deletion syndrome, AIEOP, Mendelian Inheritance in Man, Preschool, Physiologic, Genetic testing, Settore MED/38 - Pediatria Generale e Specialistica, business.industry, Retrospective cohort study, medicine.disease, Newborn, Prospective Studie, Pair 22, business
Abstract

Objective To investigate the clinical manifestations at diagnosis and during follow-up in patients with 22q11.2 deletion syndrome to better define the natural history of the disease. Study design A retrospective and prospective multicenter study was conducted with 228 patients in the context of the Italian Network for Primary Immunodeficiencies. Clinical diagnosis was confirmed by cytogenetic or molecular analysis. Results The cohort consisted of 112 males and 116 females; median age at diagnosis was 4 months (range 0 to 36 years 10 months). The diagnosis was made before 2 years of age in 71% of patients, predominantly related to the presence of heart anomalies and neonatal hypocalcemia. In patients diagnosed after 2 years of age, clinical features such as speech and language impairment, developmental delay, minor cardiac defects, recurrent infections, and facial features were the main elements leading to diagnosis. During follow-up (available for 172 patients), the frequency of autoimmune manifestations ( P = .015) and speech disorders ( P = .002) increased. After a median follow-up of 43 months, the survival probability was 0.92 at 15 years from diagnosis. Conclusions Our data show a delay in the diagnosis of 22q11.2 deletion syndrome with noncardiac symptoms. This study provides guidelines for pediatricians and specialists for early identification of cases that can be confirmed by genetic testing, which would permit the provision of appropriate clinical management.

Published
2014

39. Molecular detection of Salmonella serovars Enteritidis, Heidelberg and Typhimurium directly from pre-enriched poultry samples.

Author

Souza, M. N., Lehmann, F. K. M., De Carli, S., Kipper, D., Fonseca, A. S. K., Ikuta, N., and Lunge, V. R.

Subjects
SALMONELLA enteritidis, SALMONELLA detection, POULTRY, SALMONELLA enterica, FOODBORNE diseases, POULTRY products, SALMONELLA
Abstract

1. Salmonella is one of the most important pathogens in public health and it is usually associated with food-borne diseases. Salmonella serovars Enteritidis and Typhimurium are widespread in the world with outbreaks frequently associated with consumption of poultry products; furthermore, there is an increasing public health concern with the wide dissemination of the serovar Heidelberg in poultry flocks. 2. The aim of the experiment was to develop and to validate rapid methods to detect Salmonella serovars Enteritidis, Typhimurium, and Heidelberg by real-time PCRs and test isolates from pre-enriched poultry samples. 3. Three real-time PCRs were developed and used in combination to detect the serovars Enteritidis, Typhimurium and Heidelberg. These assays were validated by the analysis of 126 Salmonella isolates, eight other enteric bacterial species and 34 naturally contaminated poultry samples after pre-enrichment with buffered peptone water (BPW). 4. Real-time PCRs detected the isolates of the most important poultry serovars (Enteritidis, Typhimurium and Heidelberg) with 100% inclusivity and exclusivity in each assay. The PCR identified monophasic variants of the serovars Typhimurium and Heidelberg. All PCRs were validated in detecting these specific serovars directly from pre-enriched poultry samples. The whole analytical procedure was performed in less than 24 h in a veterinary diagnostic laboratory. [ABSTRACT FROM AUTHOR]

Published
2019
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40. Palatal obturators in patients after maxillectomy

Author

CARDELLI, P., BIGELLI, E., VERTUCCI, V., BALESTRA, F., MONTANI, M., DE CARLI, S., and ARCURI, C.

Subjects
Bulb, Settore MED/28 - Malattie Odontostomatologiche, Obturator, Case Report, Maxillectomy, Prosthesis, Oral-nasal communication
Abstract

Prosthodontic management of palatal defects is fundamental to improve patient’s life undergoing to a maxillary surgical treatment. A lot of maxillary defects are a direct consequence of surgical treatment of malformations, neoplasms or trauma. The obturators are prosthesis used to close palatal defects after maxillectomy, to restore masticatory function and to improve speech. The primary goals of the obturator prosthesis are to preserve the remaining teeth and tissue and to provide comfort, function, and aesthetics to the patients. Different materials and retention methods are a characteristic of new types of obturators.

Published
2014

41. A new ruthenium black dye design with improved optical properties for transparent dye sensitized solar devices.

Author

Boaretto, R., Carli, S., Caramori, S., Bignozzi, C. A., Saccone, D., Magistris, C., Barolo, C., and Viscardi, G.

Subjects
*RUTHENIUM, *DYE-sensitized solar cells, *CARBOXYLIC acids
Abstract

We report here on the preparation and on the electronic properties of a panchromatic Ru(ii) sensitizer based on a new ligand which allows for higher molar extinction coefficients in the visible and better performances (32% efficiency improvement) over conventional “black dye” in transparent DSSC. [ABSTRACT FROM AUTHOR]

Published
2017
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42. Scaling Up of Dye Solar Cells for Building Integrated PhotoVoltaics (BIPV)

Author

Artuso, Emma, Barbero, Nadia, Bignozzi, C., Boaretto, R., Brown, T. M., Bonandini, Luca, Busatto, E., Carli, S., Colonna, D., De Angelis, G., Di Carlo, A., Giordano, F., Guglielmotti, A., Guidobaldi, A., Lanuti, A., Lembo, A., Mastroianni, S., Mirruzzo, V., Penna, S., Petrolati, E., Reale, A., Riccitelli, R., Soscia, G., Vesce, L., and Viscardi, Guido

Published
2012

44. Pharmacokinetics of tramadol in horse

Author

Zonca, A., Cagnardi, P., Carli, S., Scrollavezza, P., and Villa, R.

Subjects
Settore VET/07 - Farmacologia e Tossicologia Veterinaria
Published
2006

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