96,000 results on '"Carcinogenesis"'
Search Results
2. Improvements in Thyroid Tumor Surgery and the Prognosis, Diagnosis, Recurrence and Metastasis of Patients
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- 2024
3. Changes Associated With H. Pylori and Gastric Carcinogenesis (IIT H pylori)
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- 2024
4. Role of Sodium-glucose Linked Transporter 2 (SGLT2) and Its Inhibitor Over CARdiotoxicity Induced by Anthracyclines and Breast Cancer Tumorigenesis SCARA-B (SCARA-B)
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- 2024
5. An Integrative Multi-Omic Characterization of Head and Neck Carcinogenesis, Progression and Recurrence
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National Cancer Institute (NCI)
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- 2024
6. Evaluating Obesity-Mediated Mechanisms of Pancreatic Carcinogenesis in Minority Populations
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United States Department of Defense
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- 2024
7. Switching to Potential Reduced Exposure Products in Adult Smokers (ZYN)
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- 2024
8. Chemoprevention of Gastric Carcinogenesis
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National Cancer Institute (NCI), Cancer Prevention Pharmaceuticals, Inc., and Douglas Morgan, Director, Latin America sites, Vanderbilt Institute for Global Health
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- 2024
9. HPV Immunological Markers of Cervical Persistent Infection and Oncogenesis (HPVImmuno)
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Daniele Lilleri, Principal Investigator
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- 2024
10. Inhibition of Oral Tumorigenesis by Antitumor B
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Stuart Wong, Professor
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- 2024
11. Study on the Probiotics Regulating miRNA in H. Pylori-induced Wnt/β-catenin Gastric Carcinogenesis.
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Yao-Jong Yang, professor
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- 2024
12. Abnormal Food Timing and Circadian Dyssynchrony in Alcohol Induced Colon Carcinogenesis (AFT)
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Faraz Bishehsari, MD, PhD, Assistan Professor
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- 2024
13. Microplastics: an often-overlooked issue in the transition from chronic inflammation to cancer.
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Cheng, Yicong, Yang, Yang, Bai, Ling, and Cui, Jiuwei
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CARCINOGENESIS , *TUMOR microenvironment , *MICROPLASTICS , *INFLAMMATION , *CANCER invasiveness - Abstract
The presence of microplastics within the human body has raised significant concerns about their potential health implications. Numerous studies have supported the hypothesis that the accumulation of microplastics can trigger inflammatory responses, disrupt the microbiome, and provoke immune reactions due to their physicochemical properties. Chronic inflammation, characterized by tissue damage, angiogenesis, and fibrosis, plays a crucial role in cancer development. It influences cancer progression by altering the tumor microenvironment and impairing immune surveillance, thus promoting tumorigenesis and metastasis. This review explores the fundamental properties and bioaccumulation of microplastics, as well as their potential role in the transition from chronic inflammation to carcinogenesis. Additionally, it provides a comprehensive overview of the associated alterations in signaling pathways, microbiota disturbances, and immune responses. Despite this, the current understanding of the toxicity and biological impacts of microplastics remains limited. To mitigate their harmful effects on human health, there is an urgent need to improve the detection and removal methods for microplastics, necessitating further research and elucidation. [ABSTRACT FROM AUTHOR]
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- 2024
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14. Environment and gynaecologic cancers.
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Chandra, Rudrika and Kumari, Sarita
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GYNECOLOGIC cancer , *BREAST cancer , *LUNG cancer , *CARCINOGENESIS , *INFECTION - Abstract
In the current era, environmental factors are well established as major causative agents for all cancers especially lung and breast cancer. We sought to review the current available literature on the topic pertaining to gynaecologic cancers. Although a few factors are well established in literature, others need more research to conclude. [ABSTRACT FROM AUTHOR]
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- 2024
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15. A critical review to identify data gaps and improve risk assessment of bisphenol A alternatives for human health.
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Mhaouty-Kodja, Sakina, Zalko, Daniel, Tait, Sabrina, Testai, Emanuela, Viguié, Catherine, Corsini, Emanuela, Grova, Nathalie, Buratti, Franca Maria, Cabaton, Nicolas J., Coppola, Lucia, De la Vieja, Antonio, Dusinska, Maria, El Yamani, Naouale, Galbiati, Valentina, Iglesias-Hernández, Patricia, Kohl, Yvonne, Maddalon, Ambra, Marcon, Francesca, Naulé, Lydie, and Rundén-Pran, Elise
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SYNTHETIC gums & resins , *ENDOCRINE disruptors , *EPOXY resins , *GENETIC toxicology , *IMMUNOTOXICOLOGY , *BISPHENOL A , *BISPHENOLS - Abstract
AbstractBisphenol A (BPA), a synthetic chemical widely used in the production of polycarbonate plastic and epoxy resins, has been associated with a variety of adverse effects in humans including metabolic, immunological, reproductive, and neurodevelopmental effects, raising concern about its health impact. In the EU, it has been classified as toxic to reproduction and as an endocrine disruptor and was thus included in the candidate list of substances of very high concern (SVHC). On this basis, its use has been banned or restricted in some products. As a consequence, industries turned to bisphenol alternatives, such as bisphenol S (BPS) and bisphenol F (BPF), which are now found in various consumer products, as well as in human matrices at a global scale. However, due to their toxicity, these two bisphenols are in the process of being regulated. Other BPA alternatives, whose potential toxicity remains largely unknown due to a knowledge gap, have also started to be used in manufacturing processes. The gradual restriction of the use of BPA underscores the importance of understanding the potential risks associated with its alternatives to avoid regrettable substitutions. This review aims to summarize the current knowledge on the potential hazards related to BPA alternatives prioritized by European Regulatory Agencies based on their regulatory relevance and selected to be studied under the European Partnership for the Assessment of Risks from Chemicals (PARC): BPE, BPAP, BPP, BPZ, BPS-MAE, and TCBPA. The focus is on data related to toxicokinetic, endocrine disruption, immunotoxicity, developmental neurotoxicity, and genotoxicity/carcinogenicity, which were considered the most relevant endpoints to assess the hazard related to those substances. The goal here is to identify the data gaps in BPA alternatives toxicology and hence formulate the future directions that will be taken in the frame of the PARC project, which seeks also to enhance chemical risk assessment methodologies using new approach methodologies (NAMs). [ABSTRACT FROM AUTHOR]
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- 2024
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16. Ultraviolet (UV) radiation: a double-edged sword in cancer development and therapy.
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Yu, Zhen-wei, Zheng, Min, Fan, Hua-yang, Liang, Xin-hua, and Tang, Ya-ling
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MERKEL cell carcinoma ,CANCER cell growth ,CONTROLLED release drugs ,ULTRAVIOLET radiation ,BASAL cell carcinoma ,SKIN cancer - Abstract
It has long been widely acknowledged that ultraviolet (UV) light is an environment risk factor that can lead to cancer, particularly skin cancer. However, it is worth noting that UV radiation holds potential for cancer treatment as a relatively high-energy electromagnetic wave. With the help of nanomaterials, the role of UV radiation has caught increasing attention in cancer treatment. In this review, we briefly summarized types of UV-induced cancers, including malignant melanoma, squamous cell carcinoma, basal cell carcinoma, Merkel cell carcinoma. Importantly, we discussed the primary mechanisms underlying UV carcinogenesis, including mutations by DNA damage, immunosuppression, inflammation and epigenetic alterations. Historically limited by its shallow penetration depth, the introduction of nanomaterials has dramatically transformed the utilization of UV light in cancer treatment. The direct effect of UV light itself generally leads to the suppression of cancer cell growth and the initiation of apoptosis and ferroptosis. It can also be utilized to activate photosensitizers for reactive oxygen species (ROS) production, sensitize radiotherapy and achieve controlled drug release. Finally, we comprehensively weigh the significant risks and limitations associated with the therapeutic use of UV radiation. And the contradictory effect of UV exposure in promoting and inhibiting tumor has been discussed. This review provides clues for potential clinical therapy as well as future study directions in the UV radiation field. The precise delivery and control of UV light or nanomaterials and the wavelength as well as dose effects of UV light are needed for a thorough understanding of UV radiation. [ABSTRACT FROM AUTHOR]
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- 2024
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17. RABIF promotes hepatocellular carcinoma progression through regulation of mitophagy and glycolysis.
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Feng, Ning, Zhang, Rui, Wen, Xin, Wang, Wei, Zhang, Nie, Zheng, Junnian, Zhang, Longzhen, and Liu, Nianli
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GUANINE nucleotide exchange factors , *REACTIVE oxygen species , *HEPATOCELLULAR carcinoma , *CARCINOGENESIS , *CELL growth - Abstract
The RAB interacting factor (RABIF) is a putative guanine nucleotide exchange factor that also functions as a RAB-stabilizing holdase chaperone. It has been implicated in pathogenesis of several cancers. However, the functional role and molecular mechanism of RABIF in hepatocellular carcinoma (HCC) are not entirely known. Here, we demonstrate an upregulation of RABIF in patients with HCC, correlating with a poor prognosis. RABIF inhibition results in decreased HCC cell growth both in vitro and in vivo. Our study reveals that depleting RABIF attenuates the STOML2-PARL-PGAM5 axis-mediated mitophagy. Consequently, this reduction in mitophagy results in diminished mitochondrial reactive oxygen species (mitoROS) production, thereby alleviating the HIF1α-mediated downregulation of glycolytic genes HK1, HKDC1, and LDHB. Additionally, we illustrate that RABIF regulates glucose uptake by controlling RAB10 expression. Importantly, the knockout of RABIF or blockade of mitophagy sensitizes HCC cells to sorafenib. This study uncovers a previously unrecognized role of RABIF crucial for HCC growth and identifies it as a potential therapeutic target. RABIF upregulation promotes HCC growth, mitophagy, and glycolysis, and enhances sorafenib resistance, suggesting it as a potential therapeutic target. [ABSTRACT FROM AUTHOR]
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- 2024
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18. Decreased Nuclear Immunoexpression of ING3 is a Frequent Event in Lip Carcinogenesis.
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de Barros, Joyce Magalhães, de Farias Morais, Hannah Gil, de Oliveira Costa, Carla Samily, Rolim, Larissa Santos Amaral, de Sousa Lopes, Maria Luiza Diniz, Guedes Queiroz, Lélia Maria, de Souza, Lélia Batista, and Pinto, Leão Pereira
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Purpose: Evaluate the immunohistochemical expression of the ING3 in actinic cheilitis and squamous cell carcinoma of the lower lip. Methods: Forty-five specimens of actinic cheilitis and 48 specimens of squamous cell carcinoma of the lower lip were submitted to immunohistochemical detection of ING3. The protein expression in different cellular sublocations was compared between the two groups, and associations with the clinicopathological variables were analyzed. A significance level of 5% was adopted for all tests. Results: Deaths were significantly more frequent in tumors with a high histopathological risk score (p < 0.05). In actinic cheilitis, significant differences were found in the nucleus-cytoplasmic expression of ING3 and expression restricted to the cytoplasm with binary histopathological grading (p < 0.05). In squamous cell carcinoma of the lower lip, there was no statistically significant difference when comparing ING3 expressions with clinical and morphological parameters (p > 0.05). Nucleo-cytoplasmic ING3 expression was significantly lower in squamous cell carcinoma of the lower lip when compared to actinic cheilitis (p < 0.05) and the expression restricted to the cytoplasm was significantly higher in squamous cell carcinoma of the lower lip (p < 0.05). Conclusion: The results of this study suggest that there is a marked decrease in the nuclear expression of ING3 as malignant progression occurs, indicating an impaired tumor suppressor function of this protein in actinic cheilitis and squamous cell carcinoma of the lower lip. [ABSTRACT FROM AUTHOR]
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- 2024
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19. Antitumor and chemopreventive role of major phytochemicals against breast cancer development.
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Schwarztrauber, Matthew, Edwards, Nathaniel, Hiryak, James, Chandrasekaran, Ritesh, Wild, Jayson, and Bommareddy, Ajay
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BREAST cancer ,CELL proliferation ,CARCINOGENESIS ,CELL cycle ,CELL death - Abstract
Breast cancer continues to be one of the most commonly diagnosed cancers around the world. Despite the decrease in mortality, there has been a steady increase in its incidence. There is much evidence that naturally occurring phytochemicals could prove to be safer alternatives aimed at prevention and development of breast cancer. In the present review, we discuss important phytochemicals, namely capsaicin, alpha-santalol and diallyl trisulphide that are shown to have chemopreventive and anti-tumour properties against breast cancer development. We examined current knowledge of their bioavailability, safety and modulation of molecular mechanisms including their ability to induce apoptotic cell death, promote cell cycle arrest, and inhibit cellular proliferation in different breast cancer cell lines and in vivo models. This review emphasises the importance of these naturally occurring phytochemicals and their potential of becoming therapeutic options in the arsenal against breast cancer development provided further scientific and clinical validation. [ABSTRACT FROM AUTHOR]
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- 2024
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20. The interplay of dietary mycotoxins and oncogenic viruses toward human carcinogenesis: a scoping review.
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Mouchtaris Michailidis, Thanos, De Saeger, Sarah, Khoueiry, Rita, Odongo, Grace A., Bader, Yasmine, Dhaenens, Maarten, Herceg, Zdenko, and De Boevre, Marthe
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ONCOGENIC viruses , *HUMAN papillomavirus , *HUMAN carcinogenesis , *HEPATITIS B virus , *PUBLIC health , *EPSTEIN-Barr virus , *PAPILLOMAVIRUSES - Abstract
AbstractBackgroundObjectivesMethodsResultsConclusionsMycotoxins, fungal metabolites prevalent in many foods, are recognized for their role in carcinogenesis, especially when interacting with oncogenic viruses.This scoping review synthesizes current evidence on the human cancer risk associated with mycotoxin exposure and oncogenic virus infections.Searches were conducted on PubMed, Embase, and Web of Science. Studies were selected based on the PECOS framework. Data extraction involved narrative and qualitative presentation of findings, with meta-analysis where feasible. Risk of bias and outcome quality were assessed using the OHAT tool and GRADE approach.From 25 included studies, 18 focused on aflatoxins and hepatitis viruses in hepatocellular carcinoma (HCC). Four studies examined aflatoxin B1 (AFB1) and human papilloma virus (HPV) in cervical cancer, while three investigated AFB1 with Epstein-Barr virus (EBV) in lymphomagenesis. The review highlights a significant synergistic effect between AFB1 and hepatitis B and C viruses in HCC development. Significant interactions between AFB1 and HPV, as well as AFB1 and EBV, were observed, but further research is needed.The synergistic impact of mycotoxins and oncogenic viruses is a critical public health concern. Future research, especially prospective cohort studies and investigations into molecular mechanisms, is essential to address this complex issue. [ABSTRACT FROM AUTHOR]
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- 2024
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21. Do professional painters comprise a high risk group for genotoxicity? A systematic review.
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Guedes Pinto, Thiago, Dias, Thayza Aires, and Ribeiro, Daniel Araki
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INDUSTRIAL toxicology , *DNA damage , *CARCINOGENESIS , *PAINTERS , *CANCER research , *GENETIC toxicology - Abstract
AbstractProfessional painters represent an occupational population group that deserves attention for study in the field of occupational toxicology due to the wide range of complex chemical mixtures they are exposed to. It is imperative to underscore that the International Agency for Research on Cancer has classified commercial painting as a high-risk occupation for the development of cancer. Given this context, the primary objective of the present study was to conduct a systematic review aimed at addressing the following question: are car painters at occupational risk regarding potential genotoxicity? To address this question, a selection process was undertaken, with three reviewers carefully selecting, reading, and analyzing full manuscripts from 26 studies included in this review. The technical rigor of these studies underwent meticulous scrutiny, culminating in the classification of six studies as Strong, eight as Moderate, and 12 as Weak, predicated on the extent of confounders considered. Taken together, the findings suggest that chemical substances from paints may indeed pose a risk of genotoxicity for professionals in this field, as all studies indicated genotoxicity among professional painters through various tests. [ABSTRACT FROM AUTHOR]
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- 2024
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22. Potential Role of APC Mutations in the Prognosis and Targeted Therapy of Gastric Adenocarcinoma.
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Zhang, Cao, Qin, Jingjing, Zhou, Wenjuan, Huang, Zexuan, Ye, Jingjing, He, Yaqin, and Sahgal, Pranshu
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ADENOCARCINOMA , *STOMACH tumors , *GENOMICS , *KILLER cells , *RESEARCH funding , *T cells , *CELL proliferation , *CANCER patients , *GENE expression , *ONCOGENES , *METABOLISM , *ADENOMATOUS polyposis coli , *GENETIC mutation , *HUMAN genome , *CARCINOGENESIS , *MOLECULAR biology , *DISEASE progression , *EOSINOPHILS - Abstract
Background: Adenomatous polyposis coli (APC) gene, an oncogene, has been implicated in stomach adenocarcinoma (STAD), which is a common type of gastric cancer (GC). Although the relationship between APC gene mutations and gastric adenocarcinoma has been comprehensively studied, the potential role of these mutations in the prognosis and targeted therapy remains known. Methods: We utilized The Cancer Genome Atlas (TCGA) database to obtain gene expression matrices, clinical information, and mutation data from patients with STAD. The mutation status of the APC gene was analyzed, and its correlation with tumor mutational burden (TMB), microsatellite instability (MSI), and clinical prognosis in STAD was investigated. Gene set enrichment analysis (GSEA) was conducted to explore the pathological role of APC gene mutations in STAD metabolic pathways. Drug sensitivity analysis was conducted to identify potential targeted antitumor drugs for patients with APC gene mutations in gastric adenocarcinoma. Results: The results revealed that 88% (46/52) of STAD samples had nonsynonymous mutations. The mutation group exhibited a significantly higher TMB than the wild‐type group (p < 0.001), and the percentage of high MSI (MSI‐H) was significantly higher in the mutation group than in the wild‐type group (p < 0.001). Patients with APC mutations had a worse prognosis than those with APC wild‐type (p = 0.009). The APC gene mutation group displayed significant enrichment in amino acids, RNA, and several pathways (|NES| > 1 and nominal p value < 0.01). Compared to the wild‐type group, the mutation group exhibited a higher infiltration proportion of natural killer (NK) cells resting and eosinophils, whereas a lower infiltration proportion of monocytes and resting mast cells (p value < 0.05). AZD5991 exhibited significant sensitivity in patients with STAD carrying APC mutations (p = 0.028). Conclusion:APC gene mutations play a crucial role in the prognosis, molecular characteristics, and potential therapeutic strategies for gastric adenocarcinoma. [ABSTRACT FROM AUTHOR]
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- 2024
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23. Don't fear the reaper: The role of regulated cell death in tumorigenesis and BH3-mimetics for cancer therapy.
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La Marca, John E., Kelly, Gemma L., Strasser, Andreas, and Diepstraten, Sarah T.
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APOPTOSIS , *CELL death , *CANCER cells , *CARCINOGENESIS , *CELLULAR therapy - Abstract
From its earliest characterization, it has been recognized that there is a role for regulated (programmed) cell death in cancer. As our understanding of the different types of programmed cell death processes and their molecular control has advanced, so have the technologies that allow us to manipulate these processes to, for example, fight against cancer. In this review, we describe the roles of the different forms of regulated cell death in the development of cancer as well as their potential therapeutic exploitation. In that vein, we explore the development and use of BH3-mimetics, a unique class of drugs that can directly activate the apoptotic cell death machinery to treat cancer. Finally, we address key challenges that face the field to improve the use of these therapeutics and the efforts that are being undertaken to do so. In this review, La Marca et al. delve into the role of cell death in tumorigenesis; particularly apoptosis, but also touching on emerging roles for other cell death variants. The review also discusses the development, limitations, and future of BH3-mimetics, the most clinically advanced class of compounds for direct apoptosis induction. [ABSTRACT FROM AUTHOR]
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- 2024
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24. Role of SEL1L in the progression of solid tumors, with a special focus on its recent therapeutic potential.
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Darmadi, Darmadi, Saleh, Raed Obaid, Oghenemaro, Enwa Felix, Shakir, Maha Noori, Hjazi, Ahmed, Hassan, Zahraa F., Zwamel, Ahmed Hussein, Matlyuba, Sanoeva, Deorari, Mahamedha, and Oudah, Shamam Kareem
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UNFOLDED protein response , *PROTEOLYSIS , *NEOPLASTIC cell transformation , *ETIOLOGY of cancer , *CARCINOGENESIS , *ENDOPLASMIC reticulum - Abstract
Since suppressor/enhancer of Lin‐12‐like (SEL1L) was cloned in 1997, various pieces of evidence from lower species suggest it plays a significant role in protein degradation via the ubiquitin‐proteasome system. The relevance of SEL1L in many aspects of malignant transformation and tumorigenic events has been the subject of research, which has shown compelling in vitro and in vivo findings relating its altered expression to changes in tumor aggressiveness. The Endoplasmic Reticulum (ER) in tumor cells is crucial for preserving cellular proteostasis by inducing the unfolded protein response (UPR), a stress response. A crucial component of the UPR is ER‐associated degradation (ERAD), which guards against ER stress‐induced apoptosis and the removal of unfolded or misfolded proteins by the ubiquitin‐proteasome system. As a protein stabilizer of HMG‐CoA reductase degradation protein 1 (HRD1), one of the main components of ERAD, SEL1L plays an important role in ER homeostasis. Notably, the expression levels of these two proteins fluctuate independently in various cancer types, yet changes in their expression affect the levels of other associated proteins during cancer pathogenesis. Recent studies have also outlined the function of SEL1L in cancer medication resistance. This review explores the value of targeting SEL1L as a novel treatment approach for cancer, focusing on the molecular processes of SEL1L and its involvement in cancer etiology. [ABSTRACT FROM AUTHOR]
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- 2024
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25. Oncogenic plasmid DNA and liver injury agent dictates liver cancer development in a mouse model.
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Chiu, Vincent, Yee, Christine, Main, Nathan, Stevanovski, Igor, Watt, Matthew, Wilson, Trevor, Angus, Peter, Roberts, Tara, Shackel, Nicholas, and Herath, Chandana
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LIVER cancer , *INTRAPERITONEAL injections , *LIVER injuries , *CARCINOGENESIS , *SMOOTH muscle - Abstract
Primary liver cancer is an increasing problem worldwide and is associated with significant mortality. A popular method of modeling liver cancer in mice is plasmid hydrodynamic tail vein injection (HTVI). However, plasmid-HTVI models rarely recapitulate the chronic liver injury which precedes the development of most human liver cancer. We sought to investigate how liver injury using thioacetamide contributes to the pathogenesis and progression of liver cancer in two oncogenic plasmid-HTVI-induced mouse liver cancer models. Fourteen-week-old male mice received double-oncogene plasmid-HTVI (SB/AKT/c-Met and SB/AKT/NRas) and then twice-weekly intraperitoneal injections of thioacetamide for 6 weeks. Liver tissue was examined for histopathological changes, including fibrosis and steatosis. Further characterization of fibrosis and inflammation was performed with immunostaining and real-time quantitative PCR. RNA sequencing with pathway analysis was used to explore novel pathways altered in the cancer models. Hepatocellular and cholangiocellular tumors were observed in mice injected with double-oncogene plasmid-HTVI models (SB/AKT/c-Met and SB/AKT/NRas). Thioacetamide induced mild fibrosis and increased alpha smooth muscle actin-expressing cells. However, the combination of plasmids and thioacetamide did not significantly increase tumor size, but increased multiplicity of small neoplastic lesions. Cancer and/or liver injury up-regulated profibrotic and proinflammatory genes while metabolic pathway genes were mostly down-regulated. We conclude that the liver injury microenvironment can interact with liver cancer and alter its presentation. However, the effects on cancer development vary depending on the genetic drivers with differing active oncogenic pathways. Therefore, the choice of plasmid-HTVI model and injury agent may influence the extent to which injury promotes liver cancer development. [ABSTRACT FROM AUTHOR]
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- 2024
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26. The Effects of Severe Symptoms of SARS-CoV-2 Infections on the Anti/Proapoptotic Molecules: A 6-Month Cohort Study.
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Karimi-Googheri, Masoud, Madjd, Zahra, Kiani, Jafar, Shabani, Ziba, Kazemi Arababadi, Mohammad, and Gholipourmalekabadi, Mazaher
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APOPTOSIS inhibition , *IRANIANS , *CARCINOGENESIS , *CELL survival , *HOSPITAL patients - Abstract
The plausible effects of SARS-CoV-2 infection on the expression of anti/proapoptotic molecules have been suspected. This cohort study examined the expression of p53, Bcl-2, Bid, Bak, and Bax molecules, the genes associated with induction or inhibition of apoptosis, in the SARS-CoV-2-infected patients with severe and mild symptoms in an Iranian population. In this 6-month cohort study, the expression of p53, Bcl-2, Bid, Bak, and Bax molecules was evaluated at onset of diagnosis, 24 h after symptom onset, and 6 months later in the nasopharyngeal cells of SARS-CoV-2-infected hospitalized patients and outpatients in comparison with healthy controls using the real-time PCR technique. At the onset of the study, the relative expression of p53, Bcl-2, Bid, Bak, and Bax significantly increased in the SARS-CoV-2-infected hospitalized patients and decreased after 6 months. The healthy controls showed potential positive correlations among the molecules, but the patients did not show these correlations. Since SARS-CoV-2 needs host cell survival, it appears that the virus induces the expression of Bcl-2 as an antiapoptotic molecule, and the host cells upregulate the proapoptotic molecules to neutralize the effects. Dysregulation of correlation expression of the molecules among the patients proved that SARS-CoV-2 affects the expression of the molecules involved in apoptosis. SARS-CoV-2 could be considered an important factor that regulates the expression of several molecules participating in cancer pathogenesis. [ABSTRACT FROM AUTHOR]
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- 2024
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27. Unraveling TRPV1's Role in Cancer: Expression, Modulation, and Therapeutic Opportunities with Capsaicin.
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Chinreddy, Subramanyam R., Mashozhera, Nicole Tendayi, Rashrash, Badraldeen, Flores-Iga, Gerardo, Nimmakayala, Padma, Hankins, Gerald R., Harris, Robert T., and Reddy, Umesh K.
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TRPV cation channels , *CELL communication , *CANCER pain , *CARCINOGENESIS , *PEPPERS , *HOT peppers - Abstract
Cancer is a global health challenge with rising incidence and mortality rates, posing significant concerns. The World Health Organization reports cancer as a leading cause of death worldwide, contributing to nearly one in six deaths. Cancer pathogenesis involves disruptions in cellular signaling pathways, resulting in uncontrolled cell growth and metastasis. Among emerging players in cancer biology, Transient Receptor Potential (TRP) channels, notably TRPV1, have garnered attention due to their altered expression in cancer cells and roles in tumorigenesis and progression. TRPV1, also known as the capsaicin receptor, is pivotal in cancer cell death and pain mediation, offering promise as a therapeutic target. Activation of TRPV1 triggers calcium influx and affects cell signaling linked to growth and death. Additionally, TRPV1 is implicated in cancer-induced pain and chemo-sensitivity, with upregulation observed in sensory neurons innervating oral cancers. Also, when capsaicin, a compound from chili peppers, interacts with TRPV1, it elicits a "hot" sensation and influences cancer processes through calcium influx. Understanding TRPV1's multifaceted roles in cancer may lead to novel therapeutic strategies for managing cancer-related symptoms and improving patient outcomes. The current review elucidates the comprehensive role of capsaicin in cancer therapy, particularly through the TRPV1 channel, highlighting its effects in various cells via different signaling pathways and discussing its limitations. [ABSTRACT FROM AUTHOR]
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- 2024
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28. Circulating RKIP and pRKIP in Early-Stage Lung Cancer: Results from a Pilot Study.
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Gasparri, Roberto, Papale, Massimo, Sabalic, Angela, Catalano, Valeria, Deleonardis, Annamaria, De Luca, Federica, Ranieri, Elena, and Spaggiari, Lorenzo
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PROTEIN kinase inhibitors , *COMPUTED tomography , *TUMOR markers , *LUNG cancer , *CARCINOGENESIS - Abstract
Background: Lung cancer (LC) is the leading cause of cancer-related deaths. Although low-dose computed tomography (LD-CT) reduces mortality, its clinical use is limited by cost, radiation, and false positives. Therefore, there is an urgent need for non-invasive and cost-effective biomarkers. The Raf Kinase Inhibitor Protein (RKIP) plays a crucial role in cancer development and progression and may also contribute to regulating the tumor–immune system axis. This protein has recently been described in biological fluids. Therefore, we conducted a pilot case–control study to assess RKIP and phosphorylated RKIP (pRKIP) levels in the urine and blood of LC patients. Methods: A novel enzyme linked immunosorbent assay (ELISA) assay was used to measure RKIP and pRKIP levels in urine and blood samples of two cohorts of LC patients and healthy controls (HSs). Furthermore, the biomarkers levels were correlated with tumor characteristics. Results: Serum, but not urine, levels of RKIP were significantly elevated in LC patients, distinguishing them from low- and high-risk healthy subjects with 93% and 74% accuracy, respectively. The RKIP/pRKIP ratio (RpR score) showed an accuracy of 90% and 79% in distinguishing LC patients from HS and HR-HS, respectively. Additionally, the RpR score correlated better with dimension, stage, and lymph node involvement in the tumor group. Conclusions: The serum RKIP and pRKIP profile may be a promising novel biomarker for early-stage LC. [ABSTRACT FROM AUTHOR]
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- 2024
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29. The Clinical Significance of Pancreatic Steatosis in Pancreatic Cancer: A Hospital-Based Study.
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Chan, Chia-Hao, Chang, Chia-Chen, and Peng, Yen-Chun
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MAGNETIC resonance imaging , *PANCREATIC cancer , *FATTY liver , *DISEASE risk factors , *CARCINOGENESIS - Abstract
Background/Objectives: Pancreatic cancer remains one of the deadliest malignancies worldwide with a pressing need for early detection and intervention strategies. Emerging evidence has suggested a potential link between pancreas steatosis, characterized by excessive pancreatic fat accumulation, and an increased risk of pancreatic cancer development. This retrospective imaging study aims to elucidate the association between pancreatic steatosis and the subsequent development of pancreatic cancer. In the study, we aimed to determine the characteristics of pancreatic cancer with pancreatic steatosis. Methods: During the period of January 2022 to December 2022, we conducted a retrospective study, collecting 101 newly diagnosed pancreas cancer cases from the available image datasets. A comprehensive database of retrospective abdominal imaging studies, comprising computed tomography (CT) and magnetic resonance imaging (MRI), was established from a diverse patient population and subsequently analyzed. Inclusion criteria encompassed patients having available baseline imaging data, allowing for the assessment of pancreatic fat content. Pancreatic fat content was quantified using validated radiological techniques, while demographic, clinical, and histopathological data were all collected. The clinical data and patient characteristics were collected from medical records and analyzed. Results: Preliminary analysis revealed a significant correlation between elevated pancreatic fat content and an increased incidence of subsequent pancreatic cancer. Moreover, subgroup analysis based on age, gender, and comorbidities provided valuable insight into potential risk factors associated with this progression. Additionally, the study identified novel radiological markers that may serve as early indicators of pancreatic cancer development in individuals with pancreatic steatosis. Conclusions: In the imaging study, approximately 30% (30/101) of pancreatic cancer patients presented with pancreatic steatosis. Chronic pancreatitis emerged as the primary factor contributing to pancreatic steatosis in these patients. Importantly, pancreatic steatosis did not significantly impact the prognosis of pancreatic cancer. Follow-up data revealed no significant differences in survival duration between patients with or without pancreatic steatosis. Additionally, no association was found between pancreatic steatosis and hepatic steatosis. [ABSTRACT FROM AUTHOR]
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- 2024
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30. Exploring DIX-DIX Homo- and Hetero-Oligomers in Wnt Signaling with AlphaFold2.
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Wen, Zehua, Wang, Lei, Liu, Shi-Wei, Fan, Hua-Jun Shawn, Song, Jong-Won, and Lee, Ho-Jin
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WNT signal transduction , *CELLULAR signal transduction , *HOMODIMERS , *CARCINOGENESIS , *SIGNALS & signaling - Abstract
Wnt signaling is involved in embryo development and cancer. The binding between the DIX domains of Axin1/2, Dishevelled1/2/3, and Coiled-coil-DIX1 is essential for Wnt/β-catenin signaling. Structural and biological studies have revealed that DIX domains are polymerized through head-to-tail interface interactions, which are indispensable for activating β-catenin Wnt signaling. Although different isoforms of Dvl and Axin proteins display both redundant and specific functions in Wnt signaling, the specificity of DIX-mediated interactions remains unclear due to technical challenges. Using AlphaFold2(AF2), we predict the structures of 6 homodimers and 22 heterodimers of DIX domains without templates and compare them with the reported X-ray complex structures. PRODIGY is used to calculate the binding affinities of these DIX complexes. Our results show that the Axin2 DIX homodimer has a stronger binding affinity than the Axin1 DIX homodimer. Among Dishevelled (Dvl) proteins, the binding affinity of the Dvl1 DIX homodimer is stronger than that of Dvl2 and Dvl3. The Coiled-coil-DIX1(Ccd1) DIX homodimer shows weaker binding than the Axin1 DIX homodimer. Generally, heterodimer interactions tend to be stronger than those of homodimers. Our findings provide insights into the mechanism of the Wnt signaling pathway and highlight the potential of AF2 and PRODIGY for studying protein–protein interactions in signaling pathways. [ABSTRACT FROM AUTHOR]
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- 2024
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31. From Cancer to Immune Organoids: Innovative Preclinical Models to Dissect the Crosstalk between Cancer Cells and the Tumor Microenvironment.
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Picca, Francesca, Giannotta, Claudia, Tao, Jiahao, Giordanengo, Lucia, Munir, H. M. Waqas, Botta, Virginia, Merlini, Alessandra, Mogavero, Andrea, Garbo, Edoardo, Poletto, Stefano, Bironzo, Paolo, Doronzo, Gabriella, Novello, Silvia, Taulli, Riccardo, and Bersani, Francesca
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MICROPHYSIOLOGICAL systems , *MEDICAL research , *TUMOR classification , *TUMOR microenvironment , *CARCINOGENESIS - Abstract
Genomic-oriented oncology has improved tumor classification, treatment options, and patient outcomes. However, genetic heterogeneity, tumor cell plasticity, and the ability of cancer cells to hijack the tumor microenvironment (TME) represent a major roadblock for cancer eradication. Recent biotechnological advances in organotypic cell cultures have revolutionized biomedical research, opening new avenues to explore the use of cancer organoids in functional precision oncology, especially when genomics alone is not a determinant. Here, we outline the potential and the limitations of tumor organoids in preclinical and translational studies with a particular focus on lung cancer pathogenesis, highlighting their relevance in predicting therapy response, evaluating treatment toxicity, and designing novel anticancer strategies. Furthermore, we describe innovative organotypic coculture systems to dissect the crosstalk with the TME and to test the efficacy of different immunotherapy approaches, including adoptive cell therapy. Finally, we discuss the potential clinical relevance of microfluidic mini-organ technology, capable of reproducing tumor vasculature and the dynamics of tumor initiation and progression, as well as immunomodulatory interactions among tumor organoids, cancer-associated fibroblasts (CAFs) and immune cells, paving the way for next-generation immune precision oncology. [ABSTRACT FROM AUTHOR]
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- 2024
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32. SSCI: Self-Supervised Deep Learning Improves Network Structure for Cancer Driver Gene Identification.
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Xu, Jialuo, Hao, Jun, Liao, Xingyu, Shang, Xuequn, and Li, Xingyi
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CANCER genes , *RECEIVER operating characteristic curves , *EARLY detection of cancer , *DEEP learning , *CARCINOGENESIS , *BIOLOGICAL networks - Abstract
The pathogenesis of cancer is complex, involving abnormalities in some genes in organisms. Accurately identifying cancer genes is crucial for the early detection of cancer and personalized treatment, among other applications. Recent studies have used graph deep learning methods to identify cancer driver genes based on biological networks. However, incompleteness and the noise of the networks will weaken the performance of models. To address this, we propose a cancer driver gene identification method based on self-supervision for graph convolutional networks, which can efficiently enhance the structure of the network and further improve predictive accuracy. The reliability of SSCI is verified by the area under the receiver operating characteristic curves (AUROC), the area under the precision-recall curves (AUPRC), and the F1 score, with respective values of 0.966, 0.964, and 0.913. The results show that our method can identify cancer driver genes with strong discriminative power and biological interpretability. [ABSTRACT FROM AUTHOR]
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- 2024
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33. Interplay of Cardiometabolic Syndrome and Biliary Tract Cancer: A Comprehensive Analysis with Gender-Specific Insights.
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Di Stasi, Vincenza, Contaldo, Antonella, Birtolo, Lucia Ilaria, and Shahini, Endrit
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LIVER disease diagnosis , *TREATMENT of diabetes , *LIVER disease prevention , *RISK assessment , *NON-alcoholic fatty liver disease , *WEIGHT loss , *CARDIOVASCULAR diseases , *CHOLANGIOCARCINOMA , *SEX distribution , *CARDIOVASCULAR diseases risk factors , *CHRONIC diseases , *METABOLIC syndrome , *TYPE 2 diabetes , *EARLY diagnosis , *VIRUS diseases , *DISEASE progression , *COMORBIDITY , *OBESITY , *BIOMARKERS , *SEQUENCE analysis , *DISEASE risk factors ,BILE duct tumors - Abstract
Simple Summary: Metabolic syndrome (MetS), metabolic dysfunction-associated steatotic liver disease (MASLD), and diabetes are all linked to Cholangiocarcinoma (CCA) in various ways. MASLD may have an increased risk of intrahepatic-CCA, whereas untreated patients with shorter diabetes durations were more likely to develop biliary tract cancer (BTC). More research is needed to understand how reproductive hormones cause BTC. BTC patients may be at increased intrinsic cardiovascular risk of neoplastic/non-neoplastic cardiac complications. Therefore, early detection/prevention of chronic liver disease, as well as intervention studies, will almost certainly be required to determine whether improvements in MetS, weight loss, and diabetes therapy can reduce CCA risk and progression. BTC overall incidence is globally increasing. CCA, including its subtypes, is a form of BTC. MetS, obesity, MASLD, and diabetes are all linked to CCA in interconnected ways. The link between obesity and CCA is less well-defined in Eastern countries as compared to Western. Although more research is needed to determine the relationship between MASLD and extrahepatic CCA (eCCA), MASLD may be a concurrent risk factor for intrahepatic CCA, particularly in populations with established or unidentified underlying liver disease. Interestingly, the risk of biliary tract cancer (BTC) seemed to be higher in patients with shorter diabetes durations who were not treated with insulin. Therefore, early detection and prevention of chronic liver disease, as well as additional intervention studies, will undoubtedly be required to determine whether improvements to MetS, weight loss, and diabetes therapy can reduce the risk and progression of BTC. However, further studies are needed to understand how reproductive hormones are involved in causing BTC and to develop consistent treatment for patients. Finally, it is critical to carefully assess the cardiological risk in BTC patients due to their increased intrinsic cardiovascular risk, putting them at risk for thrombotic complications, cardiovascular death, cardiac metastasis, and nonbacterial thrombotic endocarditis. This review aimed to provide an updated summary of the relation between the abovementioned cardio-metabolic conditions and BTC. [ABSTRACT FROM AUTHOR]
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- 2024
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34. Altered Microbiome Promotes Pro-Inflammatory Pathways in Oesophago-Gastric Tumourigenesis.
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Patel, Nikhil Manish, Patel, Pranav Harshad, Bhogal, Ricky Harminder, Harrington, Kevin Joseph, Singanayagam, Aran, and Kumar, Sacheen
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STOMACH tumors , *NEOPLASTIC cell transformation , *GENOMICS , *EARLY detection of cancer , *ESOPHAGEAL tumors , *HUMAN microbiota , *CELLULAR signal transduction , *AGE distribution , *INFLAMMATION , *CARCINOGENESIS , *NATURAL immunity , *GASTROESOPHAGEAL reflux , *DRUG utilization , *DISEASE risk factors - Abstract
Simple Summary: Cancer of the upper digestive system is associated with poor survival due to difficulties in diagnosing the disease early, before it has spread around the body. Previous research has shown that the healthy bacteria within the body changes in response to medications, diet and infection. Some of these changes are associated with a greater risk of developing cancers of the oesophagus (gullet) and stomach. This occurs, at least in part, through inflammation. This process is the body's natural response to infection, injury and exposure to potentially harmful substances, which, if uncontrolled can lead to diseases including cancer. This review article aims to explain the ways in which this happens. By developing a deeper understanding of these processes, advances in early diagnosis of this disease can be made, which may lead to better survival. Introduction: The upper gastrointestinal microbiome is a dynamic entity that is involved in numerous processes including digestion, production of vitamins and protection against pathogens. Many external and intrinsic factors may cause changes in the proportions of bacteria within the microbial community, termed 'dysbiosis'. A number of these have been identified as risk factors for a range of diseases, including oesophago-gastric carcinoma. Materials and Methods: A narrative review was conducted to elucidate the current evidence on the role of the microbiome in promoting oesophago-gastric tumourigenesis. Significant causes of dysbiosis including age, medications and GORD were examined and key pro-inflammatory pathways implicated in tumourigenesis and their interaction with the microbiome were described. Results and Discussion: An association between microbial dysbiosis and development of oesophago-gastric cancer may be mediated via activation of pro-inflammatory pathways, the inflammasome and the innate immune system. Advances in sequencing technology allow microbial communities to be fingerprinted by sequencing the 16S rRNA gene, enabling a deeper understanding of the genera that may be implicated in driving tumourigenesis. Conclusions: Developing a greater understanding of the influence of the microbiota on oesophago-gastric tumourigenesis may enable advances to be made in the early detection of malignancy and in the development of novel systemic therapies, leading to improved rates of survival. [ABSTRACT FROM AUTHOR]
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- 2024
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35. Role of Exosomes in Salivary Gland Tumors and Technological Advances in Their Assessment.
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Nieszporek, Artur, Wierzbicka, Małgorzata, Labedz, Natalia, Zajac, Weronika, Cybinska, Joanna, and Gazinska, Patrycja
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BIOPSY , *MEDICAL technology , *CELL physiology , *SALIVARY gland tumors , *CELLULAR signal transduction , *METASTASIS , *CARCINOGENESIS , *EXOSOMES , *DISEASE progression - Abstract
Simple Summary: Salivary gland tumors (SGTs) are rare and complex, making them difficult to diagnose and treat. This work focuses on the role of exosomes, extracellular vesicles secreted by almost all cell types, in the development and progression of SGT. Exosomes are crucial in cell-to-cell communication and play significant roles in tumor biology, including modulating the tumor environment, aiding metastasis, and affecting immune responses. A better understanding of exosome biology can lead to their use as biomarkers for diagnosis and prognosis, as well as targets for treatment, potentially transforming SGT management and improving patient outcomes. Exosome-based liquid biopsies could offer non-invasive, real-time diagnostics and enhance patient care through precision medicine. This review explores the advancements in salivary exosome analysis, highlighting its potential for non-invasive cancer detection and the development of innovative diagnostic techniques. Backgroud: Salivary gland tumors (SGTs) are rare and diverse neoplasms, presenting significant challenges in diagnosis and management due to their rarity and complexity. Exosomes, lipid bilayer vesicles secreted by almost all cell types and present in all body fluids, have emerged as crucial intercellular communication agents. They play multifaceted roles in tumor biology, including modulating the tumor microenvironment, promoting metastasis, and influencing immune responses. Results: This review focuses on the role of exosomes in SGT, hypothesizing that novel diagnostic and therapeutic approaches can be developed by exploring the mechanisms through which exosomes influence tumor occurrence and progression. By understanding these mechanisms, we can leverage exosomes as diagnostic and prognostic biomarkers, and target them for therapeutic interventions. The exploration of exosome-mediated pathways contributing to tumor progression and metastasis could lead to more effective treatments, transforming the management of SGT and improving patient outcomes. Ongoing research aims to elucidate the specific cargo and signaling pathways involved in exosome-mediated tumorigenesis and to develop standardized techniques for exosome-based liquid biopsies in clinical settings. Conclusions: Exosome-based liquid biopsies have shown promise as non-invasive, real-time systemic profiling tools for tumor diagnostics and prognosis, offering significant potential for enhancing patient care through precision and personalized medicine. Methods like fluorescence, electrochemical, colorimetric, and surface plasmon resonance (SPR) biosensors, combined with artificial intelligence, improve exosome analysis, providing rapid, precise, and clinically valid cancer diagnostics for difficult-to-diagnose cancers. [ABSTRACT FROM AUTHOR]
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- 2024
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36. Clinical Aspects and Significance of β-Chemokines, γ-Chemokines, and δ-Chemokines in Molecular Cancer Processes in Acute Myeloid Leukemia (AML) and Myelodysplastic Neoplasms (MDS).
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Korbecki, Jan, Bosiacki, Mateusz, Stasiak, Piotr, Snarski, Emilian, Brodowska, Agnieszka, Chlubek, Dariusz, and Baranowska-Bosiacka, Irena
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MYELODYSPLASTIC syndromes , *CHEMOKINES , *CELL communication , *DRUG resistance in cancer cells , *MACROPHAGES , *T cells , *CELL proliferation , *ANTINEOPLASTIC agents , *MESENCHYMAL stem cells , *CARCINOGENESIS , *CHEMOKINE receptors - Abstract
Simple Summary: This article examines the significance of β-chemokines, γ-chemokines, and δ-chemokines in acute myeloid leukemia (AML). It focuses on the effects of these chemotactic cytokines on both leukemic cells and non-leukemic cells within the tumor niche in the bone marrow. This article emphasizes the substantial impact of certain chemokines on tumorigenic processes in AML, highlighting the correlation between chemokine expression and patient prognosis. However, the mechanisms underlying this relationship remain poorly understood. The lack of comprehensive understanding of the role of chemokines in AML impedes the development of new anti-leukemic drugs targeting these chemokines and their receptors. Background/Objectives: Acute myeloid leukemia (AML) is a type of leukemia with a very poor prognosis. Consequently, this neoplasm is extensively researched to discover new therapeutic strategies. One area of investigation is the study of intracellular communication and the impact of the bone marrow microenvironment on AML cells, with chemokines being a key focus. The roles of β-chemokines, γ-chemokines, and δ-chemokines in AML processes have not yet been sufficiently characterized. Methods: This publication summarizes all available knowledge about these chemotactic cytokines in AML and myelodysplastic neoplasm (MDS) processes and presents potential therapeutic strategies to combat the disease. The significance of β-chemokines, γ-chemokines, and δ-chemokines is detailed, including CCL2 (MCP-1), CCL3 (MIP-1α), CCL5 (RANTES), CCL23, CCL28, and CX3CL1 (fractalkine). Additionally, the importance of atypical chemokine receptors in AML is discussed, specifically ACKR1, ACKR2, ACKR4, and CCRL2. Results/Conclusions: The focus is on the effects of these chemokines on AML cells, particularly their influence on proliferation and resistance to anti-leukemic drugs. Intercellular interactions with non-AML cells, such as mesenchymal stem cells (MSC), macrophages, and regulatory T cells (Treg), are also characterized. The clinical aspects of chemokines are thoroughly explained, including their effect on overall survival and the relationship between their blood levels and AML characteristics. [ABSTRACT FROM AUTHOR]
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- 2024
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37. Metabolic Dysregulation and Cancer Risk Program (MeDOC): a transdisciplinary approach to obesity-associated cancers.
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Lam, Tram Kim, Daschner, Phil, Ishibe, Naoko, Wali, Anil, Hall, Kara, Czajkowski, Susan, Mahabir, Somdat, Watson, Joanna M, Nebeling, Linda, Ross, Sharon, and Sauter, Edward
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DISEASE risk factors , *PUBLIC health , *INSULIN resistance , *SMOKING , *CARCINOGENESIS - Abstract
With the escalating prevalence of obesity, the association between obesity and cancer is a growing public health concern. Obesity will soon surpass tobacco smoking as the most important preventable cause of cancer. Obesity-driven mechanisms can alter cell functions to induce metabolic changes, chronic inflammation, and insulin resistance that are believed to contribute to cancer risk and development; yet the specific underlying biological mechanisms of obesity-related cancer development are largely unknown. The Metabolic Dysregulation and Cancer Risk Program: a transdisciplinary approach to obesity-associated cancers (MeDOC) is a trans–National Cancer Institute research initiative supported by the Division of Cancer Control and Population Sciences, the Division of Cancer Biology, the Division of Cancer Prevention, and the Center to Reduce Cancer Health Disparities. The overall purpose of the MeDOC Program is to advance our understanding of the underlying mechanisms that connect obesity, metabolic dysregulation, and increased obesity cancer risk as well as identify markers that will enhance cancer risk prediction, improve screening for high-risk individuals, and identify targets for preventive and therapeutic interventions for cancer interception or treatment. This report describes the funded research projects, the Coordinating Center, and the goals of the MeDOC program. [ABSTRACT FROM AUTHOR]
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- 2024
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38. Human Endogenous Retroviruses in Breast Cancer: Altered Expression Pattern Implicates Divergent Roles in Carcinogenesis.
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Záveský, Luděk, Jandáková, Eva, Weinberger, Vít, Minář, Luboš, Kohoutová, Milada, and Slanař, Ondřej
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BREAST tumor risk factors , *RISK assessment , *RESEARCH funding , *POLYMERASE chain reaction , *TUMOR markers , *DESCRIPTIVE statistics , *GENE expression , *TUMOR suppressor genes , *RETROVIRUSES , *CARCINOGENESIS , *SENSITIVITY & specificity (Statistics) - Abstract
Introduction: Breast cancer is the most common cancer and the leading cause of cancer death in women. Recent research indicates that human endogenous retroviruses (HERVs) may be linked to carcinogenesis, but the data remain controversial. Methods: HERVs' expression was evaluated to show the differences between breast cancer and control samples, and their associations with clinicopathological parameters. Gene expression of 12 HERVs, i.e., ERVE-4, ERVW-1, ERVFRD-1, ERVV-1, ERV3-1, ERVH48-1, ERVMER34-1, ERVK-7, ERVK13-1, ERVK11-1, ERVK3-1, and HCP5, was analyzed by qPCR and/or TCGA datasets for breast cancer. Results: ERV3-1, ERVFRD-1, ERVH48-1, and ERVW-1 provided data to support their tumor suppressor roles in breast cancer. ERV3-1 evinced the best performing diagnostic data based on qPCR, i.e., AUC: 0.819 (p < 0.0001), sensitivity of 72.41%, and specificity of 89.66%. Lower levels of ERV3-1 were noted in advanced stage and higher grades, and significant negative association was found in relation to Ki-67 levels. Oncogenic roles may be inferred for ERVK13-1, ERVV-1, and ERVMER34-1. Data for ERVK-7, ERVE-4, ERVK11-1, and HCP5 remain inconclusive. Conclusion: Differential HERV expression may be applicable to evaluate novel biomarkers for breast cancer. However, more research is needed to reveal their real clinical impact, the biological roles, and regulatory mechanisms in breast carcinogenesis. [ABSTRACT FROM AUTHOR]
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- 2024
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39. In Vivo Chemosuppressive Effects of Kolaviron on 7,12-Dimethylbenzanthracene-Induced Mammary Lesions are Associated with Changes in Levels of Estrogen Receptor-α, CYP 1A1, Proinflammatory Cytokines, and Alterations to Metabolic Pathways Implicated in Mammary Carcinogenesis
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Attah, Catherine Ojebbah, Alhaji, Umar Ismail, Ameh, Danladi Amodu, Forcados, Gilead Ebiegberi, Muhammad, Aliyu, Bashir, Musa, and Ibrahim, Sani
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TYROSINE metabolism , *RESEARCH funding , *ANTINEOPLASTIC agents , *BREAST tumors , *CELLULAR signal transduction , *IN vivo studies , *PLANT extracts , *ESTROGEN receptors , *RATS , *DOSE-effect relationship in pharmacology , *SULFONAMIDES , *CYTOCHROME P-450 , *ANIMAL experimentation , *CYTOKINES , *PHARMACODYNAMICS , *BLOOD ,BREAST tumor prevention - Abstract
Garcinia kola is a medicinal food commonly consumed in Sub-Sahara Africa, for which Kolaviron (KV) is the active portion. As a follow-up to our earlier chemopreventive studies, we investigated the chemotherapeutic effects of KV on experimentally induced mammary carcinogenesis in female Wistar rats. Mammary carcinogenesis was induced using 80 mg/kg of 7,12-dimethylbenzanthracene (DMBA) administered by oral gavage. One hundred-fifty days post-DMBA induction, estrogen receptor-α (ER-α) levels were determined in the experimental rats before treatment with KV commenced. Treatment was done using 50, 100, and 200 mg/kg KV thrice a week for 4 weeks, after which the experiment was terminated. Significantly higher levels of estrogen receptor-α, CYP 1A1, malondialdehyde, formation of lobular neoplastic cells, epithelial hyperplasia, lymphocyte infiltration, and increased cytokine (interleukin-6 and tumor necrosis factor-α) activity were observed in DMBA-induced rats, which were attenuated in KV-treated rats. Tyrosine metabolism was exclusively enriched in DMBA-induced rats in contrast to KV-treated rats. Collectively, the results point to the chemotherapeutic potential of KV. [ABSTRACT FROM AUTHOR]
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- 2024
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40. Molecular impact of mutations in RNA splicing factors in cancer.
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Zhang, Qian, Ai, Yuxi, and Abdel-Wahab, Omar
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RNA splicing , *CARCINOGENESIS , *GENETIC mutation , *INTRONS , *RNA , *SMALL nuclear RNA - Abstract
Somatic mutations in genes encoding components of the RNA splicing machinery occur frequently in multiple forms of cancer. The most frequently mutated RNA splicing factors in cancer impact intronic branch site and 3′ splice site recognition. These include mutations in the core RNA splicing factor SF3B1 as well as mutations in the U2AF1/2 heterodimeric complex, which recruits the SF3b complex to the 3′ splice site. Additionally, mutations in splicing regulatory proteins SRSF2 and RBM10 are frequent in cancer, and there has been a recent suggestion that variant forms of small nuclear RNAs (snRNAs) may contribute to splicing dysregulation in cancer. Here, we describe molecular mechanisms by which mutations in these factors alter splice site recognition and how studies of this process have yielded new insights into cancer pathogenesis and the molecular regulation of splicing. We also discuss data linking mutant RNA splicing factors to RNA metabolism beyond splicing. Mutations in genes encoding components of the RNA splicing machinery occur frequently in multiple cancers. This review describes the molecular mechanisms by which cancer-associated mutations in splicing factors alter splice site recognition and how studies of this process have yielded new insights into cancer pathogenesis and the molecular regulation of splicing. [ABSTRACT FROM AUTHOR]
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- 2024
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41. Pooled Rate of Pseudoprogression, Patterns of Response, and Tumor Burden Analysis in Patients Undergoing Immunotherapy Oncologic Trials for Different Malignancies.
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Morrissey, S., Vasconcelos, A.G., Wang, C.L., Wang, S., and Cunha, G.M.
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TUMOR treatment , *IMMUNOTHERAPY , *FISHER exact test , *LOGISTIC regression analysis , *CANCER patients , *RETROSPECTIVE studies , *CHI-squared test , *DESCRIPTIVE statistics , *LONGITUDINAL method , *TUMORS , *CARCINOGENESIS , *CONFIDENCE intervals - Abstract
Assess rates of true pseudoprogression in unconfirmed progressive disease (iUPD) in a pool of immunotherapy clinical trials for different cancers, analyze tumor characteristics that drive iUPD classification, and investigate potentials predictors of pseudoprogression. Retrospective interpretation of prospectively acquired data. Patients from 18 immunotherapy clinical trials with two arms (RECIST 1.1, iRECIST), of 10 cancer types were selected. Pooled rate of true pseudoprogression among iUPD was estimated using a common effect meta-analysis. Target, Non-target, and new lesions as the trigger of confirmed-vs pseudo-progression were compared using Chi-Square and Fisher exact tests. Conditional logistic regression was used to investigate the association between age, sex, tumor burden at baseline, and number of follow ups and pseudoprogression. 60/287 (21%) patients (17 women) were classified as iUPD with at least one subsequent confirmatory timepoint. The overall pooled estimate of pseudoprogression was 15% (95%CI: 8%–-26%). Nontarget lesions were significantly more frequent the cause of iUPD than change in Target lesions size (p < 0.001). Most observations of true pseudoprogression occurred in the first follow-up (77%), whereas confirmed progression occurred in later time points during the trial. Pseudoprogression was not significantly associated with age, sex, tumor burden at baseline, or number of timepoints. In a pool of immunotherapy trials, the rate of true pseudoprogression was 15%, most often in the first timepoint after baseline than later in treatment. iUPD categorization was mostly driven by changes in NT lesions rather than objective changes in measurements of target lesions. • Considering trials size and proportions, the pooled estimate of true pseudoprogression was 15% (95%CI: 8%–26%). • Confirmed progression and pseudoprogression were mainly driven by change in Non-target lesions than size of target lesions. • Pseudoprogression occurred most often in the first follow-up after baseline than true progression. [ABSTRACT FROM AUTHOR]
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- 2024
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42. Regular exercise suppresses steatosis‐associated liver cancer development by degrading E2F1 and c‐Myc via circadian gene upregulation.
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Huyen, Vu Thuong, Echizen, Kanae, Yamagishi, Ryota, Kumagai, Miho, Nonaka, Yoshiki, Kodama, Takahiro, Ando, Tatsuya, Yano, Megumu, Takada, Naoki, Takasugi, Masaki, Kamachi, Fumitaka, and Ohtani, Naoko
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LIVER cancer , *GENE expression profiling , *CARCINOGENESIS , *CELL proliferation , *CANCER prevention , *CIRCADIAN rhythms - Abstract
Regular exercise is believed to suppress cancer progression. However, the precise molecular mechanisms by which exercise prevents cancer development remain unclear. In this study, using a steatosis‐associated liver cancer mouse model, we found that regular exercise at a speed of 18 m/min for 20 min daily suppressed liver cancer development. To explore the underlying mechanisms, we examined the gene expression profiles in the livers of the exercise and non‐exercise groups. The expressions of circadian genes, such as Per1 and Cry2, were upregulated in the exercise group. As circadian rhythm disruption is known to cause various diseases, including cancer, improving circadian rhythm through exercise could contribute to cancer prevention. We further found that the expression of a series of E2F1 and c‐Myc target genes that directly affect the proliferation of cancer cells was downregulated in the exercise group. However, the expression of E2F1 and c‐Myc was transcriptionally unchanged but degraded at the post‐translational level by exercise. Cry2, which is regulated by the Skp1‐Cul1‐FBXL3 (SCFFBXL3) ubiquitin ligase complex by binding to FBXL3, can form a complex with E2F1 and c‐Myc, which we think is the mechanism to degrade them. Our study revealed a previously unknown mechanism by which exercise prevents cancer development. [ABSTRACT FROM AUTHOR]
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- 2024
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43. A Single-Center Retrospective Analysis of Kaposi's Sarcoma: Is There a Relationship Between Emmprin/CD147 Expression and Biological Behavior?
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Yusifli, Zarifa, Ismayilov, Rashad, Kosemehmetoglu, Kemal, and Gedikoglu, Gokhan
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KAPOSI'S sarcoma-associated herpesvirus , *KAPOSI'S sarcoma , *DISEASE relapse , *CELL migration , *CARCINOGENESIS - Abstract
Objectives. Emmprin (CD147/BSG) protein is estimated to play a key role in cell migration and chemoresistance in viral carcinogenesis. However, there are very limited studies investigating the CD147 in the oncogenesis of Kaposi's sarcoma-associated herpesvirus. This study aims to reveal the relationship between CD147 expression with histopathological parameters, disease pattern, and recurrence in Kaposi's sarcoma (KS). Methods. The study included 67 patients diagnosed with KS between January 1982 and September 2023. Clinical and histopathological features were analyzed retrospectively. HHV-8, CD31, and CD147 expressions were evaluated by immunohistochemistry. Results. Sixteen (24%) female and 51 (76%) male patients with median age of 64 (10-86) were included in the study. CD147 was positive in 57 (85%) cases and associated with nodular pattern (P =.001), presence of solid/fibrosarcomatous area (P =.005), and high mitotic activity (P =.035). The disease relapsed in 17 (27%) of the 63 patients with median 2 (0-12) years follow-up. While a 5-year relapse-free survival was 48.5% in the CD147 diffuse positive group, it was 83.4% in focal positive and 100% in negative cases (P =.029). Conclusion. Our study exhibited the relationship between CD147 overexpression and recurrence in KS, but the inhomogeneity of the treatment groups and the small number of patients should also be considered. These findings may provide insight into the pathogenesis of KS and the development of targeted therapies in the future. [ABSTRACT FROM AUTHOR]
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- 2024
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44. Vitamin D-Regulated miR-589-3p in Patients with Cervical Cancer Predicts Patient Prognosis and is Involved in Tumor Progression.
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Wu, Qi, Zhang, Lin, Sun, Youmeng, and Ying, Jinhong
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CELL migration , *PREDICTIVE tests , *PREDICTION models , *COLORIMETRY , *RESEARCH funding , *MICRORNA , *CELL proliferation , *CANCER patients , *DESCRIPTIVE statistics , *CELL motility , *REVERSE transcriptase polymerase chain reaction , *CALCITRIOL , *CELL lines , *KAPLAN-Meier estimator , *GENE expression , *CELL culture , *MICROBIOLOGICAL assay , *COMPARATIVE studies , *CONFIDENCE intervals , *CARCINOGENESIS , *PROPORTIONAL hazards models , *OVERALL survival , *DISEASE progression ,CERVIX uteri tumors - Abstract
The study aims to evaluate the performance of Vitamin D/calcitriol-induced miR-589-3p in predicting the prognosis of cervical cancer patients and its role in cancer cell function. To identify differentially expressed miRNAs (DEMs) related to calcitriol treatment, the GSE61829 dataset was analyzed. MiR-589-3p expression levels were verified in cervical cancer patients. The association of miR-589-3p with overall survival was investigated using Kaplan-Meier survival analyses and the multi-variate Cox proportional hazards model analysis. The effects of miR-589-3p on cervical cancer cells and calcitriol-treated cells were examined using the MTT assay and Transwell migration/invasion assay. From GSE61829 dataset, a total of eleven DEMs were identified, including miR-589-3p. MiR-589-3p was found to be decreased in cervical cancer but increased after one-year intake of Vitamin D. Low miR-589-3p after one-year intake of Vitamin D was identified as a predictive factor for low survival probability (p = 0.0059) with a significant impact on the death risk (HR: 3.04; 95%CI: 1.47-6.29; p = 0.003). MiR-589-3p overexpression inhibited the proliferation and migration/invasion of cervical cancer cells and calcitriol-treated cervical cancer cells. In conclusion, miR-589-3p can be induced by Vitamin D/calcitriol treatment and inhibit cervical cancer progression. MiR-589-3p has the potential to predict overall survival in patients with cervical cancer. [ABSTRACT FROM AUTHOR]
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- 2024
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45. Regulation of Fuzheng Huayu capsule on inhibiting the fibrosis-associated hepatocellular carcinogenesis.
- Author
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Zhang, Wen-Qi, Sun, Jia-Xin, Lan, Shu-Ting, Sun, Xiao-Mei, Guo, Yi-Jing, Wen, Bi-Chao, Chen, Jie, and Liu, Gang
- Subjects
- *
LIVER tumors , *CHINESE medicine , *RISK assessment , *CIRRHOSIS of the liver , *ARACHIDONIC acid , *HERBAL medicine , *HYDROCARBONS , *IN vivo studies , *QUALITY control , *CELLULAR signal transduction , *DESCRIPTIVE statistics , *BIOINFORMATICS , *QUERCETIN , *GENES , *EXPERIMENTAL design , *IMMUNOHISTOCHEMISTRY , *ANIMAL experimentation , *MOLECULAR structure , *ONE-way analysis of variance , *CARCINOGENESIS , *LIVER , *COMPARATIVE studies , *DATA analysis software , *HEPATOCELLULAR carcinoma , *PHARMACEUTICAL encapsulation , *NITROSOAMINES , *TUMOR necrosis factors , *ALGORITHMS , *DISEASE progression , *SEQUENCE analysis , *LIVER function tests , *NONPARAMETRIC statistics - Abstract
In the current study, bioinformatics analysis of the hepatocellular carcinoma (HCC) dataset was conducted with the hepatoprotective effect of the Fuzheng Huayu (FZHY) capsule against the diethylnitrosamine-induced HCC progression analyzed. Eight cell clusters were defined and tanshinone IIA, arachidonic acid, and quercetin, compounds of the FZHY capsule, inhibit HCC progression-related fibrosis by regulating the expression of PLAU and IGFBP3. Combined with the ameliorative effect of the FZHY capsule against liver dysfunctions and expression of PLAU and IGFBP3, our study confirmed the effect of the FZHY capsule on inhibiting the fibrosis-associated HCC progression via regulating the expression of PLAU and IGFBP3. [ABSTRACT FROM AUTHOR]
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- 2024
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46. Vitamin D Significantly Inhibits Carcinogenesis in the Mogp-TAg Mouse Model of Fallopian Tube Ovarian Cancer.
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Nelson, Omar L., Rosales, Rebecca, Turbov, Jane, Thaete, Larry G, Balamayooran, Gayathriy, Cline, J Mark, Pike, J. Wesley, and Rodriguez, Gustavo C.
- Abstract
Epidemiological and observational studies suggest that vitamin D has potential for the chemoprevention of ovarian cancer. The anticancer effect of vitamin D in the fallopian tube epithelium (FTE), which is now thought to harbor the precursor cells for high grade ovarian cancer, is not known. The purpose of this study was to investigate whether vitamin D can inhibit carcinogenesis in the mogp-TAg fallopian tube (FT) ovarian cancer mouse model and examine underlying mechanisms. To test this hypothesis, 3 groups of 40 5-week-old female mogp-TAg mice were divided equally into two cohorts of 20 mice, treated with either vehicle (vitamin D solvent) or the active 1,25(OH)2D3 analogue EB1089, delivered via mini-pump or IP injection or cholecalciferol delivered in the feed. The FTs were characterized histologically and pathologically after 3 and 7 weeks of treatment. The effect of vitamin D on cultured human FTE cells was also examined. After 3 weeks, vitamin D, delivered as either cholecalciferol or EB1089 significantly inhibited FT carcinogenesis. After 7 weeks, cholecalciferol significantly reduced p53 signatures, serous tubal epithelial carcinoma, FT cancer, and plasma CA125 while increasing apoptosis in the FTE. EB1089 had no significant effect on FT carcinogenesis at 7 weeks. Cholecalciferol significantly reduced proliferation and increased apoptosis in vitro in p53-altered FTE cells. In conclusion, vitamin D inhibited FT carcinogenesis by clearing cells with p53 alterations. These data suggest that vitamin D has merit for the chemoprevention of fallopian tube/ovarian cancer. The optimal chemopreventive effect may be dependent on the route of vitamin D administration [ABSTRACT FROM AUTHOR]
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- 2024
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47. Association between inflammatory factors and melanoma: a bidirectional Mendelian randomization study.
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Lu, Jiamin, Feng, Yuqian, Guo, Kaibo, Sun, Leitao, and Zhang, Kai
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C-reactive protein ,INTERLEUKIN-1 ,CLINICAL medicine ,SENSITIVITY analysis ,INTERLEUKIN-6 ,MELANOMA - Abstract
Purpose: This study performed a bidirectional Mendelian randomization (MR) analysis to elucidate the causal relationships of C-reactive protein and 41 inflammatory regulators with melanoma, including data from UK Biobank, Cardiovascular Risk in Young Finns Study, and Cohorts for Inflammation Work Group. Methods: We selected the inverse variance weighting (IVW) to merge the estimated causal effects of multiple SNPs into a weighted average. To evaluate the heterogeneities of IVW, the Cochran Q statistic, and I
2 index were used. What's more, several sensitivity analyses were employed, including IVW, MR-Egger, weighted median, and Mendelian Randomization Pleiotropy RESidual Sum and Outlier (MR-PRESSO). Results: With SNPs reaching P < 5 × 10−8 , the analyses findings revealed that IL-16 had a significant positively association with genetically risk of melanoma (ORIVW : 1.05; 95% CI: 1.03–1.07; P < 0.001), and high levels of MCP1 (ORIVW : 1.13; 95% CI: 1.03–1.23; P = 0.01) were suggestively associated with melanoma susceptibility. What's more, TNF-β (ORIVW : 1.07; 95% CI: 1.01–1.13; P = 0.02) and IL-8 (ORIVW : 1.08, 95% CI: 1.01–1.16; P = 0.03) were demonstrated a positive association with the risk of melanoma under a less stringent cut-off (P < 5 × 10−6 ). Conversely, we found a facilitative effect of melanoma susceptibility on IP-10 and inhibitory effects on IL-6, IL-1b, and GRO-α. Conclusion: The genetic evidence that we have uncovered indicates a potential association between the levels of specific inflammatory markers (IL-16, IL-8, MCP-1, and TNF-β) and the risk of melanoma. Further research is imperative to translate these findings into clinical applications. [ABSTRACT FROM AUTHOR]- Published
- 2024
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48. The Influence of Removable Complete Denture on Pro‐Oxidant Antioxidant Balance and Redox‐Sensitive Inflammation Biomarker NF‐ĸB in the Oral Cavity: An Interventional Follow‐Up Study.
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Bošković, Mirjana, Sokolović, Dušan, Stanković, Saša, Ristić, Ivan, Popović, Jordan, and Kocić, Gordana
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COMPLETE dentures ,TRANSCRIPTION factors ,CLINICAL trials ,INFLAMMATORY mediators ,REACTIVE oxygen species ,ORAL lichen planus - Abstract
Objectives: Oxidative stress, an imbalance between the body's natural antioxidant defenses and the production of reactive oxygen species (ROS), can result in serious oral diseases, including oral cancer, periodontal diseases, and oral lichen planus, through the activation of the redox‐sensitive transcription factors and inflammation. The purpose of this study was to assess the potential effects of a removable complete denture on the levels of oxidative stress markers, such as lipid peroxidation (MDA), advanced oxidation protein products (AOPP), and catalase, and the quantitative expression of the redox‐sensitive transcription factor NF‐κB p65 subunit. Materials and Methods: This interventional follow‐up study enrolled 40 participants of both sexes aged 28–78 years, with a median age of 56 years, where unstimulated saliva was collected before denture placement, immediately after the denture placement, and 24 h, 7 days, and 30 days after the denture placement. The most prominent ROS overproduction was reported on the seventh day (p < 0.05), followed by a significant fall in antioxidative defense. Results: The NF‐κB p65 subunit, whose expression pattern was highest in the same time period on the seventh day, serves as a signaling molecule for redox imbalance due to ROS production. Over the next 30 days, its levels remained moderately increased compared to the basal value, which may influence pro‐inflammatory pathways and the integrity of oral tissue components. These alterations may be induced by the dentures, which can produce high pressures on the supporting tissues or by the synthetic materials used for producing the dentures. Conclusion: Our research may help to clarify the potential pathways by which oxidative stress and redox‐sensitive inflammatory mediators, as well as mechanical and chemical irritants, may serve as risk factors for premalignant lesions in the mouth. Further research on this topic is required to understand the molecular mechanisms behind the relationship between inflammation and oral premalignant lesions caused by mechanical and chemical irritation. [ABSTRACT FROM AUTHOR]
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- 2024
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49. Gut bacteria, host immunity, and colorectal cancer: From pathogenesis to therapy.
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Li, Yuyi, Peng, Jinjin, and Meng, Xiangjun
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GUT microbiome ,COLORECTAL cancer ,CARCINOGENESIS ,IMMUNE response ,DYSBIOSIS - Abstract
The emergence of 16S rRNA and metagenomic sequencing has gradually revealed the close relationship between dysbiosis and colorectal cancer (CRC). Recent studies have confirmed that intestinal dysbiosis plays various roles in the occurrence, development, and therapeutic response of CRC. Perturbation of host immunity is one of the key mechanisms involved. The intestinal microbiota, or specific bacteria and their metabolites, can modulate the progression of CRC through pathogen recognition receptor signaling or via the recruitment, polarization, and activation of both innate and adaptive immune cells to reshape the protumor/antitumor microenvironment. Therefore, the administration of gut bacteria to enhance immune homeostasis represents a new strategy for the treatment of CRC. In this review, we cover recent studies that illuminate the role of gut bacteria in the progression and treatment of CRC through orchestrating the immune response, which potentially offers insights for subsequent transformative research. [ABSTRACT FROM AUTHOR]
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- 2024
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50. Exposure to polycyclic aromatic hydrocarbons promotes the progression of low‐grade cervical intraepithelial neoplasia: A population‐based cohort study in China.
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Cui, Meng, Song, Li, Mao, Rui, Lyu, Yuanjing, Ding, Ling, Wang, Zhilian, Pei, Ruixin, Yan, Jiaxin, Wu, Caihong, Li, Xiaoxue, Jia, Haixia, Zhang, Le, Zhang, Mingxuan, Wang, Jiahao, and Wang, Jintao
- Subjects
HUMAN papillomavirus ,POLYCYCLIC aromatic hydrocarbons ,PRECANCEROUS conditions ,CARCINOGENESIS ,CERVICAL cancer ,CERVICAL intraepithelial neoplasia - Abstract
Low‐grade cervical intraepithelial neoplasia (CIN1) is an early stage of cervical cancer development. Previously, we reported that exposure to polycyclic aromatic hydrocarbons (PAHs) increases the risk of cervical precancerous lesions, especially in females with a high‐risk human papillomavirus (HR‐HPV) infection. However, the effects of PAHs on CIN1 progression remain unclear. A community‐based prospective cohort study was conducted to evaluate the role of exposure to PAHs in the progression of CIN1. A total of 564 patients diagnosed with CIN1 were followed‐up at 6, 12, and 24 months, post‐diagnosis, to determine CIN1 reversion, persistence, and progression. Exposure to PAHs was determined by the urine 1‐hydroxipayrene (1‐OHP) level. Our results showed that the 1‐OHP level was significantly higher in patients with CIN1 persistence/progression than in those with reversion (P <.05). High exposure to PAHs increased the risk of CIN1 persistence/progression, with hazard ratios (HR), 95% confidence intervals (CI) of (1.62, 1.24–2.67), (1.98, 1.42–2.75), and (2.37, 1.61–3.49) at 6, 12, and 24 months, post‐diagnosis, respectively. The effect was enhanced with HR‐HPV positivity, as determined at 6 (1.82, 1.24–2.67), 12 (3.02, 1.74–5.23), and 24 (2.51, 1.48–4.26) months, post‐diagnosis. Moreover, the predictive value of exposure to PAHs for CIN1 persistence/progression was higher in HR‐HPV‐positive patients than in HR‐HPV‐negative patients. The results revealed that exposure to PAHs facilitated the malignant progression of CIN1 and hindered its reversal, particularly in patients with HR‐HPV infection. Our findings provide novel insights into early prevention and intervention targeting the initiation and progression of cervical neoplasia. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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