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1. A Prospective Cohort Analysis of the Prevalence and Predictive Factors of Delayed Discharge After Laparoscopic Cholecystectomy in Italy: The DeDiLaCo Study

Author

Cillara, Nicola, Podda, Mauro, Cicalò, Enrico, Sotgiu, Giovanni, Provenzano, Maria, Fransvea, Pietro, Poillucci, Gaetano, Sechi, Raffaele, Deserra, Antonello, DʼAgostino, Francesca, Margiani, Carla, Scabini, Stefano, Pertile, Davide, Rosa, Raffaele De, Prosperi, Paolo, Bruscino, Alessandro, Bella, Annamaria Di, Casati, Massimiliano, Laface, Letizia, Abate, Emmanuele, Frontali, Alice, Bonomi, Alessandro Michele, Ferrario, Luca, Mucilli, Felice, Barone, Mirko, Borghi, Felice, Sasia, Diego, Giraudo, Giorgio, Puzziello, Alessandro, Loffredo, Andrea, Steccanella, Francesca, Donnarumma, Elio, Galleano, Raffaele, Malerba, Michele, Runfola, Matteo, Agus, Marcello, Fortunato, Federica, Calò, Pietro Giorgio, Medas, Fabio, Canu, Gian Luigi, Stella, Marco, Ferrara, Francesco, Baldi, Caterina, Benuzzi, Laura, Pisanu, Adolfo, Saba, Alessandra, Gessa, Emanuela, Muratore, Andrea, Calabrò, Marcello, Cuzzola, Bruno, Garino, Mauro, Marafante, Chiara, Farfaglia, Roberto, Pandolfo, Gianpiero, Pata, Giacomo, Lantone, Giulio, Marino, Fabio, Perrone, Fabrizio, Scognamillo, Fabrizio, Delogu, Daniele, Tilocca, Pier Luigi, Frena, Antonio, Malpaga, Anna, Bertelli, Giacomo, Memeo, Riccardo, Ferraro, Valentina, Libia, Annarita, Sarro, Giuliano, Marconi, Matteo, Nava, Samuele, Pierpaolo, Bordoni, Fleres, Francesco, Clarizia, Guglielmo, Alfieri, Sergio, Rosa, Fausto, Longo, Fabio, Restini, Enrico, Cianci, Pasquale, Capuzzolo, Sabino, Anania, Gabriele, Bombardini, Cristina, Urbani, Alessia, Bona, Davide, Aiolfi, Alberto, Lastraioli, Caterina, Paola, Massimiliano Di, DallʼOglio, Anna, D’Eletto, Marco, Capelli, Patrizio, Conti, Luigi, Luzietti, Enrico, Banchini, Filippo, Manca, Giuseppe, Calo, Gabriele’, Centomze, Antonella, Andreano, Mauro, Sullo, Pasquale, Giuseppina, Oliva, Anastasi, Alessandro, Canonico, Giuseppe, Nelli, Tommaso, Trompetto, Mario, Gallo, Gaetano, Clerico, Giuseppe, Arganini, Marco, Palmeri, Matteo, Bonuso, Claudio, Mirabella, Antonello, Marino, Marco V., Vaccarella, Gianpaolo, Salzano, Francesco, Meccariello, Renato, Mastrorilli, Maurizio, Campanile, Fabio Cesare, Foti, Nicola, Angelis, Monica De, Palma, Giovanni Domenico De, Aprea, Giovanni, Palomba, Giuseppe, Milone, Marco, Capano, Mariana, Manigrasso, Michele, Baldazzi, Gianandrea, Cassini, Diletta, Epifani, Angelo Gabriele, Bottino, Vincenzo, Canfora, Alfonso, Ferronetti, Antonio, de Manzini, Nicolò, Biloslavo, Alan, Fracon, Stefano, Filauro, Marco, Barberis, Andrea, Azzinnaro, Antonio, Oliva, Alba, Razzore, Andrea, Maira, Lorenzo Di, Bima, Carlo, Gibin, Enrico, Peluso, Chiara, Perrotta, Nicola, Celiento, Marta, Scorzelli, Marco, Tuveri, Antonio, Madeddu, Francesco, Fois, Claudia, Russello, Domenico, Latteri, Saverio, Sofia, Maria, Rio, Paolo Del, Cozzani, Federico, Giuffrida, Mario, Mariani, Pierpaolo, Giussani, Martina, Ansaloni, Luca, Maestri, Marcello, Tartaglia, Giuseppe, Caricato, Marco, Capolupo, Gabriella Teresa, Carannante, Filippo, Gambino, Giovanni, Bertino, Vanessa, Bonilauri, Stefano, Frazzetta, Giuseppe, Amodio, Pietro Maria, Siena, Teresa De, Zanzi, Federico, Guariniello, Anna, Rocco, Giuseppe, Mancini, Stefano, Sagnotta, Andrea, Solinas, Luigi, Porta, Andrea, Sambucci, Daniele, Monti, Eleonora, Quaglino, Francesco, Mantova, Serena, Fiore, Alessia, Costi, Renato, Virgilio, Edoardo, Montali, Filippo, Catarci, Marco, Apa, Daniela, Bertoldi, Innocenzo, Camandona, Michele, Bossotti, Maurizio, Palagi, Silvia, Doria, Emaunele, Caltagirone, Alice, Balani, Alessandro, Petronio, Barbara, Terranova, Susanna, Martuzzi, Federica, Romeo, Carlo, Carluccio, Raffaele, Neri, Silvia, Auriemma, Pasquale Pio, Prestigiacomo, Giorgia, Sala, Stefano, Colli, Francesco, Marini, Pierluigi, Cosimo, Carla Di, Gattolin, Andrea, Rimonda, Roberto, Travaglio, Elisabetta, Cotsoglou, Christian, Granieri, Stefano, Chierici, Andrea Piero, Tamini, Nicolò, Pitoni, Ludovica, Vico, Eleonora, Altomare, Donato Francesco, Martines, Gennaro, Tomasicchio, Giovanni, Coppola, Massimiliano, Aprile, Giovanna, Sau, Paolo, Papa, Mauro Del, Manzi, Fulvio, DʼAmata, Gabriele, Cocorullo, Gianfranco, Venturelli, Paolina, Carollo, Giuseppe, Tondolo, Vincenzo, Dore, Andrea, Giorgio, Danilo Di, Gusai, Giovanni Pietro Paolo, Salaris, Claudia, Sanna, Silvia, Pignata, Giusto, Andreuccetti, Jacopo, DʼAlessio, Rossella, Massani, Marco, Tutino, Roberta, Viola, Vincenzo, Stella, Luigi Persico, Diana, Massimo, Sampietro, Gianluca Matteo, Merlini, David Alessio, Sica, Giuseppe, Bagaglini, Giulia, Manzia, Tommaso Maria, Siracusa, Leandro, Tisone, Giuseppe, Ercolani, Giorgio, DʼAcapito, Fabrizio, Pietrantonio, Daniela Di, Fiscon, Valentino, Portale, Giuseppe, Cipollari, Chiara, Sorrentino, Mario, Piccolo, Roberta, Cojutti, Alessandro, Canova, Gualtiero, Nicotera, Antonella, Zago, Marcello, Montis, Giorgio De, Castaldi, Fabio, Morelli, Maria Morena, Parma, Emilio, Paolini, Claudia, Marco, Giovanni De, Elter, Chiara, Feo, Carlo V., Fabbri, Nicolò, Severi, Silvia, Nasto, Aurelio, Patrone, Renato, Conti, Lorenzo, Rizzi, Andrea, Broggi, Luca, Danelli, Piergiorgio, Cammarata, Francesco, Fiore, Luigi, Grande, Michele, Campanelli, Michela, and Grande, Simona

Published
2023
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2. Predictive factors of intestinal necrosis in acute mesenteric ischemia

Author

Canfora Alfonso, Ferronetti Antonio, Marte Gianpaolo, Maio Vittorio Di, Mauriello Claudio, Maida Pietro, Bottino Vincenzo, Aprea Giovanni, and Amato Bruno

Subjects
acute mesenteric ischemia, irreversible transmural intestinal necrosis, explorative laparotomy, predictive factors, Medicine
Abstract

Acute mesenteric ischemia (AMI) is a gastrointestinal and vascular emergency in which the detection of patients requiring intestinal resection is mandatory.

Published
2019
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3. A prospective non-randomized controlled, multicenter trial comparing Appendectomy and Conservative Treatment for Patients with Uncomplicated Acute Appendicitis (the ACTUAA study)

Author

Podda, Mauro, Serventi, Fernando, Mortola, Lorenzo, Marini, Stefano, Sirigu, Danilo, Piga, Michela, Pisano, Marcello, Coppola, Massimiliano, Agresta, Ferdinando, Virdis, Francesco, Di Saverio, Salomone, Cillara, Nicola, Balestra, Francesco, Ottonello, Roberto, Lai, Antonio, Piro, Silverio, Argenio, Giulio, Gemini, Sergio, Pala, Miriam, Piras, Mario, Erdas, Enrico, Nicolosi, Angelo, Gordini, Luca, Podda, Francesco, Pisanu, Adolfo, Atzeni, Jenny, Poillucci, Gaetano, De Nisco, Carlo, Casciu, Luigi, Piano, Maurizio, Labate, Salvatore, Saba, Luca, Aresu, Simona, Azzinnaro, Antonio, Ioia, Giovanna, Turri, Luciano, Pulighe, Fabio, Anania, Marco, Canfora, Alfonso, Bottino, Vincenzo, Piazza, Diego, Luridiana, Gianluigi, Serra, Piergiorgio, Saba, Alessandra, Tuveri, Antonio, Pinna, Giovanni, Piredda, Antonella, Madeddu, Francesco, Caneva, Patrizia Dalla, Delogu, Daniele, Saliu, Antonella, Cogoni, Gianfranco, Deserra, Antonello, Pau, Renata, Cossu, Sergio, Canu, Luisa, Marcias, Gianni, Garau, Franco, Loi, Salvatore, Bellisano, Giulia, Presenti, Luigi, Maccioni, Antonio, Norcia, Giorgio, Piras, Emanuele, Fiume, Stefania, Pitzalis, Antonella, Bianco, Paola, Cappai, Mariangela, Cadeddu, Flavio Nicola, Manca, Alessandra, Occhioni, Giovanni, Rossi, Arianna Magoni, Rizzo, Salvatore, Centonze, Maurizio, Portolano, Vincenzo, Barbareschi, Mattia, Barrasi, Elena, Martorana, Martina, Ferro, Franca, Casarini, Claudia, Stella, Giorgio, Generoso, Paola, Rossi, Sabina, Abelli, Fabrizio, Casula, Laura, Gerardi, Chiara, Bertele’, Vittorio, and The ACTUAA Study Collaborative Working Group

Published
2017
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4. IPOD Study: Management of Acute Left Colonic Diverticulitis in Italian Surgical Departments

Author

Sartelli, Massimo, Binda, Gian Andrea, Brandara, Francesco, Borasi, Andrea, Feroci, Francesco, Vadalà, Salvatore, Labricciosa, Francesco M., Birindelli, Arianna, Luridiana, Gianluigi, Coccolini, Federico, Di Saverio, Salomone, Catena, Fausto, Ansaloni, Luca, Campanile, Fabio Cesare, Agresta, Ferdinando, Piazza, Diego, Anania, Gabriele, Caproli, Emanuele, Gasparrini, Marcello, Bordoni, Pierpaolo, Lucchi, Andrea, Scabini, Stefano, Picardi, Biagio, Sarro, Giuliano, Piccinini, Alice, Bedin, Natalino, Bussotti, Alessandro, De Angelis, Renato, Baiocchi, Gian Luca, Andreotti, Antonella, Cillara, Nicola, Petronio, Barbara, Grimaldi, Sergio, Biancafarina, Alessia, Somenzi, Dario, Costanzi, Andrea, Marvaso, Alberto, Canfora, Alfonso, Vasquez, Giorgio, Chiodo, Carlo, Nano, Mario, Cavicchi, Angelo, Ruffato, Alberto, Baccari, Paolo, Polastri, Roberto, Marsanic, Patrizia, Portale, Giuseppe, Gordini, Luca, Abongwa, Hariscine K, Pili, Michela, Turati, Luca, Nusca, Vittoria, Guercioni, Gianluca, Delogu, Leonardo Andrea, Robustelli, Umberto, Piras, Danilo, Serventi, Fernando, Prando, Daniela, Brunelli, Antonio, Zani, Bruno, Pintaldi, Salvatore, Verzelli, Augusto, Mulas, Silvia, Confalonieri, Gianmaria, Spagni, Giuditta, Crucitti, Antonio, Sagnotta, Andrea, Fiume, Stefania, Balestra, Francesco, Gatti, Matteo, Eugeni, Emilio, Carraro, Amedeo, Genna, Michele, Taglietti, Lucio, Azzinnaro, Antonio, Ferfoglia, Stefano, Miranda, Giuseppe, Tirone, Giuseppe, Luparello, Pietro, Berti, Stefano, Tutino, Roberta, De Manzoni Garberini, Andrea, Roscio, Francesco, Maglione, Valeria, Podda, Mauro, Ioia, Giovanna, Cantore, Fabrizio, Mazzalai, Franco, Cortesi, Francesco, Arcuri, Giacomo, Bellanova, Giovanni, Beltramo, Massimo, Chessa, Antonella, Coppola, Massimiliano, Gozzo, Davide, Harbi, Asaf, Minciotti, Edoardo, Pata, Francesco, Pinna, Giovanni, Testini, Mario, Vanella, Serafino, and IPOD study Collaborative Working Group

Published
2017
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6. Morpho-functional gastric pre-and post-operative changes in elderly patients undergoing laparoscopic cholecystectomy for gallstone related disease

Author

Aprea Giovanni, Canfora Alfonso, Ferronetti Antonio, Giugliano Antonio, Guida Francesco, Braun Antonio, Battaglini Ciciriello Melania, Tovecci Federica, Mastrobuoni Giovanni, Cardin Fabrizio, and Amato Bruno

Subjects
Surgery, RD1-811
Abstract

Abstract Background Cholecystectomy, gold standard treatment for gallbladder lithiasis, is closely associated with increased bile reflux into the stomach as amply demonstrated by experimental studies. The high prevalence of gallstones in the population and the consequent widespread use of surgical removal of the gallbladder require an assessment of the relationship between cholecystectomy and gastric mucosal disorders. Morphological evaluations performed on serial pre and post – surgical biopsies have provided new acquisitions about gastric damage induced by bile in the organ. Methods 62 elderly patients with gallstone related disease were recruited in a 30 months period. All patients were subjected to the most appropriate treatment (Laparoscopic cholecystectomy). The subjects had a pre-surgical evaluation with: • dyspeptic symptoms questionnaire, • gastric endoscopy with body, antrum, and fundus random biopsies, • histo-pathological analysis of samples and elaboration of bile reflux index (BRI). The same evaluation was repeated at a 6 months follow-up. Results In our series the duodeno-gastric reflux and the consensual biliary gastritis, assessed histologically with the BRI, was found in 58% of the patients after 6 months from cholecystectomy. The demonstrated bile reflux had no effect on H. pylori’s gastric colonization nor on the induction of gastric precancerous lesions. Conclusions Cholecystectomy, gold standard treatment for gallstone-related diseases, is practiced in a high percentage of patients with this condition. Such procedure, considered by many harmless, was, in our study, associated with a significant risk of developing biliary gastritis after 6 months during the postoperative period.

Published
2012
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7. GERD in elderly patients: surgical treatment with Nissen-Rossetti laparoscopic technique, outcome

Author

Aprea Giovanni, Ferronetti Antonio, Canfora Alfonso, Cardin Fabrizio, Giugliano Antonio, Guida Francesco, Braun Antonio, Battaglini Ciciriello Melania, Tovecci Federica, Mastrobuoni Giovanni, and Amato Bruno

Subjects
Surgery, RD1-811
Abstract

Abstract Background The gastro-esophageal reflux disease (GERD) is one of the most frequent disease of the upper gastro-entheric tract. Surgical treatment is reserved to selected patients, affected by severe forms of disease and/or without compliance to medical therapy. In 95%-60% of the patients submitted to surgical antireflux intervention, a notable improvement of the quality of life is observed. Functional evaluations performed on pre and post – surgical pHmetric and manometric examination have provided new acquisitions about improvements in the restoration of anatomical and functional integrity of the esophagus-gastric antireflux barrier. Methods 45 elderly patients with GERD were recruited in a 27 months period. All patients were subjected to laparoscopic Nissen-Rossetti 360° fundoplication. The subjects had a pre-surgical evaluation with: • 24 hours pHmetry, • esophageal manometry, The same evaluation was repeated 1 month and 6 months after surgical intervention. Results In our series all patients get benefit from surgical treatment, with an improvement of pHmetric and manometric parameters and a regression of complications of GERD such as Barrett's metaplasia. In 8.33% of patients a PPI therapy was necessary, after the surgical intervention, to control symptoms. Conclusions The role of surgery in GERD concerns selected patients. Nissen-Rossetti mini-invasive approach is performed with an acceptable percentage of complications (3%-10%). This technique is associated with a good control of GERD symptoms in a short and middle term and with an improvement of functional parameters, such as pHmetric and manometric.

Published
2012
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8. Diverticular disease hospital cost impact analysis: evaluation of testings and surgical procedures in inpatient and outpatient admissions

Author

Aprea Giovanni, Giugliano Antonio, Canfora Alfonso, Cardin Fabrizio, Ferronetti Antonio, Guida Francesco, Braun Antonio, Battaglini Ciciriello Melania, Tovecci Federica, Mastrobuoni Giovanni, and Amato Bruno

Subjects
Surgery, RD1-811
Abstract

Abstract Background Diverticular Disease (DD) is a common condition in Italy and in other western countries. There is not much data concerning DD’s impact on budget and activity in hospitals. Methods The aim is to detect the clinical workload and the financial impact of diverticular disease in hospitals. Retrospective observational study of all patients treated for diverticular disease during the period of seven years in AOU Federico II. Analysis of inpatient and outpatient investigations, treatment, hospitalization and financial refunds. Results A total of 738 patients were treated and 840 hospital discharge records were registered. There were a total number of 4101 hospitalization days and 753 outpatient accesses. The investigations generated were 416 endoscopies, 197 abdominal CT scans, 177 abdominal ultrasound scans, 109 X-rays tests. A total of 193 surgical operations were performed. The total cost of this activity was € 1.656.802 or 0.2% of the total budget of the hospital. € 1.346.218, were attributable to the department of general surgery, 0.9% of the department’s budget . Conclusions The limited impact of diverticular disease on the budget and activity of AOU Federico II of Naples is mainly due to the absence of an emergency department.

Published
2012
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9. Appendectomy versus conservative treatment with antibiotics for patients with uncomplicated acute appendicitis: a propensity score–matched analysis of patient-centered outcomes (the ACTUAA prospective multicenter trial).

Author

Podda, Mauro, Poillucci, Gaetano, Pacella, Daniela, Mortola, Lorenzo, Canfora, Alfonso, Aresu, Simona, Pisano, Marcello, Erdas, Enrico, Pisanu, Adolfo, Cillara, Nicola, The ACTUAA Study Collaborative Working Group, Serventi, Fernando, Marini, Stefano, Sirigu, Danilo, Piga, Michela, Coppola, Massimiliano, Balestra, Francesco, De Nisco, Carlo, Pazzona, Marco, and Anania, Marco

Abstract

Purpose: The aim of this prospective multicenter study was to compare antibiotic therapy and appendectomy as treatment for patients with uncomplicated appendicitis confirmed by ultrasound and/or computed tomography. Methods: The study was conducted from January 2017 to January 2018. Data regarding all patients discharged from the participating centers with a diagnosis of uncomplicated appendicitis were collected prospectively. Results: Of the 318 patients enrolled in the study, 27.4% underwent antibiotic-first therapy, and 72.6% underwent appendectomy. The matched group was composed of 87 patients in both study arms. Of the 87 patients available of 1-year follow-up in the antibiotic-first group, 64 (73.6%) did not require appendectomy. The complication-free treatment success in the antibiotic-first group was 64.4%. A statistically significant higher complication-free treatment success was found in the appendectomy group: 81.8% in the pre-matching sample and 83.9% in the post-matching sample. Patients in the antibiotic-first group reported lower VAS scores compared to those treated with an appendectomy, both at discharge (2.0 ± 1.7 vs 3.6 ± 2.3) and at 30-day follow-up (0.3 ± 0.6 vs 2.1 ± 1.7). The mean of the days of absence from work was higher in the appendectomy group (β 0.63; 95% CI 0.08–1.18). Conclusion: Although laparoscopic appendectomy remains the gold standard of treatment for uncomplicated appendicitis, conservative treatment with antibiotics is a safe option in most cases. Approximately 65% of patients treated with antibiotics are symptom-free at 1 year, without increased risk of adverse events should symptoms recur, and better outcomes in terms of less pain and shorter period of absence from work compared to patients undergoing an appendectomy. Trial registration: Clinicaltrials.gov identifier (NCT number): NCT03080103 [ABSTRACT FROM AUTHOR]

Published
2021
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10. Mesenteric cystic lymphangioma in adult: a case series and review of the literature.

Author

Aprea, Giovanni, Guida, Francesco, Canfora, Alfonso, Ferronetti, Antonio, Giugliano, Antonio, Ciciriello, Melania Battaglini, Savanelli, Antonio, and Amato, Bruno

Subjects
ABDOMINAL diseases, LYMPHANGIOGRAPHY, MEDICAL radiography, SURGICAL excision, ABDOMINAL pain, PERITONEUM
Abstract

The article presents five case studies of adult patients with mesenteric lymphangioma (ML) including a 67-year-old female with a dull abdominal pain, a 68-year-old male patient with a painless abdominal swelling, and an 80-year-old male patient complained of diffuse abdominal pain. The rare peritoneal cavity, unclear etiology, and the difficulty in the preoperative diagnosis of lymphangiomas are cited. The article discusses the ideal method of complete surgical resection in treating ML.

Published
2013
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11. Correction to: Appendectomy versus conservative treatment with antibiotics for patients with uncomplicated acute appendicitis: a propensity score–matched analysis of patient-centered outcomes (the ACTUAA prospective multicenter trial).

Author

Podda, Mauro, Poillucci, Gaetano, Pacella, Daniela, Mortola, Lorenzo, Canfora, Alfonso, Aresu, Simona, Pisano, Marcello, Erdas, Enrico, Pisanu, Adolfo, Cillara, Nicola, Serventi, Fernando, Marini, Stefano, Sirigu, Danilo, Piga, Michela, Coppola, Massimiliano, Balestra, Francesco, De Nisco, Carlo, Pazzona, Marco, Anania, Marco, and Pulighe, Fabio

Abstract

A Correction to this paper has been published: https://doi.org/10.1007/s00384-021-03862-5 [ABSTRACT FROM AUTHOR]

Published
2021
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12. Acute diverticulitis: surgery timing in elderly patients.

Author

Aprea, Giovanni, Giugliano, Antonio, Canfora, Alfonso, Ferronetti, Antonio, Guida, Francesco, Ciciriello, Melania Battaglini, Savanelli, Antonio, Cuomo, Rosario, Sarnelli, Giovanni, and Amato, Bruno

Subjects
DIVERTICULITIS, COLON diseases, GERIATRIC surgery
Abstract

An abstract of the article "Acute diverticulitis: surgery timing in elderly patients" by Giovanni Aprea, Antonio Giugliano, Alfonso Canfora, Antonio Ferronetti, Francesco Guida, Melania Battaglini Ciciriello, Antonio Savanelli, Rosario Cuomo, and Giovanni Sarnelli is presented.

Published
2013
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13. 7 years-delayed presentation of a traumatic diaphragmatic rupture: laparoscopic repair.

Author

Aprea, Giovanni, Canfora, Alfonso, Ferronetti, Antonio, Giugliano, Antonio, Guida, Francesco, Ciciriello, Melania Battaglini, Savanelli, Antonio, and Amato, Bruno

Subjects
LAPAROSCOPIC surgery, HERNIA, COMPUTED tomography, DYSPNEA, WOUNDS & injuries
Abstract

Post-traumatic diaphragmatic hernias(PDH) are possible complications of blunt and penetrating thoracic or abdominal trauma. These hernias may be diagnosed at the time of the initial trauma, but are sometimes recognized only after several months or years during examinations for their related symptoms. We here present the case of a patient in which diagnosis was obtained only after 7 years from the accident and for which a successful laparoscopic repair of the hernia was performed. [ABSTRACT FROM AUTHOR]

Published
2013
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14. Laparoscopic Toupet fundoplication: a alternative chance in elderly patients with GERD.

Author

Ferronetti, Antonio, Canfora, Alfonso, Giugliano, Antonio, Savanelli, Antonio, Guida, Francesco, Ciciriello, Melania Battaglini, Amato, Bruno, and Aprea, Giovanni

Subjects
FUNDOPLICATION, LAPAROSCOPIC surgery, GERIATRIC surgery
Abstract

An abstract of the article "Laparoscopic Toupet fundoplication: a alternative chance in elderly patients with GERD" by Antonio Ferronetti, Alfonso Canfora, Antonio Giugliano, Antonio Savanelli, Francesco Guida, Melania Battaglini Ciciriello, Bruno Amato, and Giovanni Aprea is presented.

Published
2013
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15. Bilateral benign multinodular goiter: What is the adequate surgical therapy? A review of literature.

Author

Mauriello, Claudio, Marte, Gianpaolo, Canfora, Alfonso, Napolitano, Salvatore, Pezzolla, Angela, Gambardella, Claudio, Tartaglia, Ernesto, Lanza, Michele, and Candela, Giancarlo

Subjects
CLINICAL trials, COST effectiveness, GOITER, HYPOPARATHYROIDISM, NECK surgery, PARALYSIS, REOPERATION, THYROIDECTOMY, VOCAL cord diseases
Abstract

Background: Benign multinodular goiter (BMNG) is the most common endocrine disease requiring surgery. During the last few years a more aggressive approach has become the trend for bilateral BMNG treatment.Method: Randomized clinical trials of any size that compared bilateral subtotal resection, Dunhill procedure and total thyroidectomy for benign multinodular goiter, published between January 2000 and the end of March 2015, were reviewed.Discussion: Total thyroidectomy can be considered the most reliable approach in preventing recurrence. The Dunhill procedure is related to a higher rate of recurrence, but rarely recurrences after Dunhill procedure lead to reoperation. Total thyroidectomy avoid completion thyroidectomy for incidental carcinoma and its related risks. Recurrent laryngeal nerve (RLN) palsy becomes less common as surgical experience increases. Transient and permanent hypoparathyroidism is strictly related to the extent of neck dissection. In the risk-cost analysis we must consider the type of patient candidated to surgery and the impact of the surgical protocol we apply. When thyroid surgery is taken in consideration, specific complication rates of different procedures in each hospital must be analyzed accordingly to patient-specific risk factors and local expertise.Conclusion: The Dunhill procedure seems to be a good compromise between radicality and prevention of complications, avoiding reoperation for recurrence or completion thyroidectomy for incidental thyroid carcinoma. More follow-up studies and prospective studies are necessary to better evaluate, definitively, whether to prefer total thyroidectomy or Dunhill procedure in case of benign goiter surgery. [ABSTRACT FROM AUTHOR]

Published
2016
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16. Appendectomy versus conservative treatment with antibiotics for patients with uncomplicated acute appendicitis: a propensity score-matched analysis of patient-centered outcomes (the ACTUAA prospective multicenter trial)

Author

Gaetano Poillucci, Nicola Cillara, Enrico Erdas, M. Pisano, Mauro Podda, S Aresu, Daniela Pacella, Lorenzo Mortola, Alfonso Canfora, Adolfo Pisanu, Podda, Mauro, Poillucci, Gaetano, Pacella, Daniela, Mortola, Lorenzo, Canfora, Alfonso, Aresu, Simona, Pisano, Marcello, Erdas, Enrico, Pisanu, Adolfo, and Cillara, Nicola

Subjects
medicine.medical_specialty, 03 medical and health sciences, 0302 clinical medicine, Multicenter trial, Internal medicine, medicine, Appendectomy, Prospective cohort study, Adverse effect, Uncomplicated appendicitis, business.industry, Clinical outcome, Patient-centered outcomes, Gold standard, Gastroenterology, Hepatology, medicine.disease, Antibiotic treatment, Appendicitis, Multicenter study, Surgery, 030220 oncology & carcinogenesis, Propensity score matching, 030211 gastroenterology & hepatology, business, Conservative treatment
Abstract

Purpose: The aim of this prospective multicenter study was to compare antibiotic therapy and appendectomy as treatment for patients with uncomplicated appendicitis confirmed by ultrasound and/or computed tomography. Methods: The study was conducted from January 2017 to January 2018. Data regarding all patients discharged from the participating centers with a diagnosis of uncomplicated appendicitis were collected prospectively. Results: Of the 318 patients enrolled in the study, 27.4% underwent antibiotic-first therapy, and 72.6% underwent appendectomy. The matched group was composed of 87 patients in both study arms. Of the 87 patients available of 1-year follow-up in the antibiotic-first group, 64 (73.6%) did not require appendectomy. The complication-free treatment success in the antibiotic-first group was 64.4%. A statistically significant higher complication-free treatment success was found in the appendectomy group: 81.8% in the pre-matching sample and 83.9% in the post-matching sample. Patients in the antibiotic-first group reported lower VAS scores compared to those treated with an appendectomy, both at discharge (2.0 ± 1.7 vs 3.6 ± 2.3) and at 30-day follow-up (0.3 ± 0.6 vs 2.1 ± 1.7). The mean of the days of absence from work was higher in the appendectomy group (β 0.63; 95% CI 0.08-1.18). Conclusion: Although laparoscopic appendectomy remains the gold standard of treatment for uncomplicated appendicitis, conservative treatment with antibiotics is a safe option in most cases. Approximately 65% of patients treated with antibiotics are symptom-free at 1 year, without increased risk of adverse events should symptoms recur, and better outcomes in terms of less pain and shorter period of absence from work compared to patients undergoing an appendectomy. Trial registration: Clinicaltrials.gov identifier (NCT number): NCT03080103.

Published
2021

17. Laparoscopic versus open gastrectomy with extended lymph node dissection for gastric carcinoma in a Western series: a Propensity Score Matching analysis.

Author

Maida P, Marte G, Spedicato GA, Ferronetti A, Mauriello C, Canfora A, Ciorra G, Barra L, and Di Maio V

Subjects
Adenocarcinoma secondary, Adult, Aged, Aged, 80 and over, Female, Humans, Lymphatic Metastasis, Male, Middle Aged, Propensity Score, Retrospective Studies, Stomach Neoplasms pathology, Adenocarcinoma surgery, Gastrectomy methods, Laparoscopy, Lymph Node Excision methods, Stomach Neoplasms surgery
Published
2019
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