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5. Correction to: The Intensive Care Global Study on Severe Acute Respiratory Infection (IC-GLOSSARI): a multicenter, multinational, 14-day inception cohort study

Author

Sakr, Yasser, Ferrer, Ricard, Reinhart, Konrad, Beale, Richard, Rhodes, Andrew, Moreno, Rui, Timsit, Jean Francois, Brochard, Laurent, Thompson, B. Taylor, Rezende, Ederlon, Chiche, Jean Daniel, Auer, J., Schatzl, G., Mach, K., Gruber, H., Schreurs, E., Vander Laenen, M., Ceunen, H., Wauters, J., Francois, G., Deschamps, P., Castanares, D., Debels, D., Pierrakos, C., Vincent, J. L., Taccone, F., Vymazal, T., Gornik, I., Vujiaklija Brajkovic, A., Medici, R., Nielsen, J., Bendtsen, A., Siegel, H., Suonsyrjä, T., Hraech, S., Daviaux, F., Guillot, M., Castelain, V., Losser, R-R., Novy, E., Bouadma, L., Misset, B., Philippart, F., Mallat, J., Zogheib, E., Miclo, M., Teboul, J-L., Anguel, N., Darmon, M., Pham, T., Barberet, G., Plantefeve, G., Floccard, B., Kheladze, Z., Bloos, F., Faltlhauser, A., Helmes, T., Zacharowski, K., Meybohm, P., Schwarzkopf, K., Christ, M., Baumgaertel, M., John, S., Nentwich, J., Deja, M., Goldmann, A., Gottschalk, A., Honig, F., Siepe, B., Goebel, U., Lehmke, J., Behrens, S., Fiedler, K., Sagoschen, I., Riessen, R., Haap, M., Simon, Ph., Kaisers, U., Behrens, S., Niesen, M., Jaschinski, U., Hoersch, S., Jung, A., Allgaeuer, S., Haake, H., Lange, A., Papanikolaou, M., Balla, M., Giannakou, M., Soultati, I., Nikos, G., Koulouras, V., Kyriazopoulos, G., Gkika, D., Vlachogianni, G., Psaroulis, K., Mouloudi, E., Massa, E., Nichol, A., Meany, E., Motherway, C., Bellani, G., Pota, V., Schiavone, V., Girardis, M., Busani, S., Petrucci, N., Di Pasquale, R., Mazzini, P., Molin, A., Pellerano, G., Volta, C., Spadaro, S., Guarracino, F., Savioli, M., Pellis, T., Chinellato, N., Gatta, A., Cecchini, F., Raineri, S. M., Cortegiani, A., Kekstas, G., Karosas, V., Anguseva, T., Mitrev, Z., Beck, O., Cimic, N., Janssen, G., Bormans, L., Kuiper, M., Koopmans, K., Den Boer, S., de Groot, M., Dennesen, P., van den Bosch, J., Kluge, G., Mikaszewska-Sokolewicz, M., Lazowski, T., Chruscikowski, M., Machon, J., Adamik, B., Kübler, A., Wieczorek, A., Afonso, S., Matos, R., Catorze, N., Araujo, A., Costa, Z., Pais-de-Lacerda, A., Martins, I., Cardiga, R., Fernandes, L., Serra, I., Martinho, A., Tomescu, D., Popescu, M., Scarlatescu, E., Stoica, R., Macri, A., Filipescu, D., Rupnik, E., Tomic, V., Sifrer, F., Sole Violan, J., Ferrer Agüero, J. M., Izura, J., Monedero, P., de Cabo, C. Muños, Aguilar, G., Belda, F. J., Blanquer, J., Nives Carbonell, E., Lopez-Delgado, J-C., Aragon, C., Joya, C., Ortiz-Leyba, C., Fernandez Gonzalez, C. J., de la Torre-Prados, M-V., Puerto-Morlan, A., Araujo Aguilar, P., Tomás Marsilla, J. I., Vera Aratcoz, P., Olmo, A., Ferrer Roca, R., Catalan, R. M., Garcia Olivares, P., Albis, A., Alvarez, M., Corcoles Gonzalez, V., Gutierrez Rubio, J. M., Montoiro Allue, R., Rubio Mateo-Sidron, J., Hobrok, M., Cecconi, M., Di Tomasso, N., Raj, A., Szakmany, T., Srinivasa, L., Mathew, S., Ferguson, A., Blahut-Zugaj, M., Watters, M., Henderson, S., Sim, M., Csabi, P., O’Neill, O., Nutt, C., Humphreys, S., Bhowmick, K., Donnelly, A., O’Kane, S., Garfield, M., Jha, R., Unni, N., Gordon, A., Rubulotta, F., Ravi, K., Lunch, G., Franco, F., Higgs, D., Strandvik, G., Jonas, A., Hopkins, Ph., Hurst, T., Bellini, A., Balogun, O., Srinivasan, R., Ostermann, M., Alexander, P., McCalman, K., Bedford, J., Fulop, M., Brescia, G., Strachan, J., Meyer, J., Stotz, M., Brett, S., Zand, F., Nikandish, R., Hashemian, S., Jamaati, H., Alsheikhly, A. S., Almekhlafi, G., Albarrak, M., Maghrabi, A., Salahuddin, N., Aisa, T., Atalan, H. K., Sungur, M., Hegazi, M., Bauer, P., Mukkera, S., Fried, J., Barger, M., Gueret, R., Gonzalez, C., Lovesio, C., Dellera, Ch., Barrios, D., Leite Mendes, C., Gottardo, P., Caser, E., Santos, C., Carvalho, A., Teixeira, C., Samaniego, W., Whittle, S., Molano, D., Rojas, A., Guerra, K., Villamagua, B., Salgado-Yepez, E., Morocho, D., Remache-Vargas, N., Ñamendys-Silva, S., Rodriguez, D., Dominguez, G., Barraza, G., Bermudez-Aceves, E., Sanchez-Hurtado, L. A., Baltazar-Torres, J. A., Quispe Sierra, R., Chavez, C., von Osten, I., Van Haren, C., Smalley, N., Kol, M., Wong, H., Smith, R., Yu, L., Wu, X., Chao, L., Zhai, Q., Wu, D., Zhang, X., Jing, X., Bigornia, R., Ikeda-Maquiling, Y., Robles, J., Palo, J. E., Nguyen, T., Dao, C., Dixit, S., Gurjar, M., Reddy, P., Pravin, A., Simran, S., Ramakrishnan, N., Shetty, R., Udwadia, F., Faraz, M., Indraratna, K., Rajasinhe, J., and IC-GLOSSARI Investigators and ESICM Trials Group

Published
2017
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8. Recoil imaging for directional detection of dark matter, neutrinos, and physics beyond the Standard Model

Author

O'Hare, C. A. J., Loomba, D., Altenmüller, K., Álvarez-Pol, H., Amaro, F. D., Araújo, H. M., Sierra, D. Aristizabal, Asaadi, J., Attié, D., Aune, S., Awe, C., Ayyad, Y., Baracchini, E., Barbeau, P., Battat, J. B. R., Bell, N. F., Biasuzzi, B., Bignell, L. J., Boehm, C., Bolognino, I., Brunbauer, F. M., Caamaño, M., Cabo, C., Caratelli, D., Carmona, J. M., Castel, J. F., Cebrián, S., Cogollos, C., Collison, D., Costa, E., Dafni, T., Dastgiri, F., Deaconu, C., De Romeri, V., Desch, K., Dho, G., Di Giambattista, F., Díez-Ibáñez, D., D'Imperio, G., Dutta, B., Eldridge, C., Elliott, S. R., Ezeribe, A. C., Fava, A., Felkl, T., Fernández-Domínguez, B., Ribas, E. Ferrer, Flöthner, K. J., Froehlich, M., Galán, J., Galindo, J., García, F., Pascual, J. A. García, Gelli, B. P., Ghrear, M., Giomataris, Y., Gnanvo, K., Gramellini, E., Di Cortona, G. Grilli, Hall-Wilton, R., Harton, J., Hedges, S., Higashino, S., Hill, G., Holanda, P. C., Ikeda, T., Irastorza, I. G., Jackson, P., Janssens, D., Jones, B., Kaminski, J., Katsioulas, I., Kelly, K., Kemmerich, N., Kemp, E., Korandla, H. B., Kraus, H., Lackner, A., Lane, G. J., Lewis, P. M., Lisowska, M., Luzón, G., Lynch, W. A., Maccarrone, G., Mack, K. J., Majewski, P. A., Mano, R. D. P., Margalejo, C., Markoff, D., Marley, T., Marques, D. J. G., Massarczyk, R., Mazzitelli, G., McCabe, C., McKie, L. J., McLean, A. G., McNamara, P. C., Mei, Y., Messina, A., Mills, A. F., Mirallas, H., Miuchi, K., Monteiro, C. M. B., Mosbech, M. R., Muller, H., da Luz, H. Natal, Nakamura, K. D., Natochii, A., Neep, T., Newstead, J. L., Nikolopoulos, K., Obis, L., Oliveri, E., Orlandini, G., de Solórzano, A. Ortiz, von Oy, J., Papaevangelou, T., Pérez, O., Perez-Gonzalez, Y. F., Pfeiffer, D., Phan, N. S., Piacentini, S., Olloqui, E. Picatoste, Pinci, D., Popescu, S., Prajapati, A., Queiroz, F. S., Raaf, J. L., Resnati, F., Ropelewski, L., Roque, R. C., Ruiz-Choliz, E., Rusu, A., Ruz, J., Samarati, J., Santos, E. M., Santos, J. M. F. dos, Sauli, F., Scharenberg, L., Schiffer, T., Schmidt, S., Scholberg, K., Schott, M., Schueler, J., Segui, L., Sekiya, H., Sengupta, D., Slavkovska, Z., Snowden-Ifft, D., Soffitta, P., van Stenis, M., Spooner, N. J. C., Strigari, L., Stuchbery, A. E., Sun, X., Torelli, S., Tilly, E. G., Thomas, A. W., Thorpe, T. N., Urquijo, P., Utrobičić, A., Vahsen, S. E., Veenhof, R., Vogel, J. K., Williams, A. G., Wood, M. H., and Zettlemoyer, J.

Subjects
High Energy Physics - Experiment (hep-ex), High Energy Physics - Phenomenology, Cosmology and Nongalactic Astrophysics (astro-ph.CO), High Energy Physics - Phenomenology (hep-ph), Physics - Instrumentation and Detectors, Physics::Instrumentation and Detectors, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Experiment
Abstract

Recoil imaging entails the detection of spatially resolved ionization tracks generated by particle interactions. This is a highly sought-after capability in many classes of detector, with broad applications across particle and astroparticle physics. However, at low energies, where ionization signatures are small in size, recoil imaging only seems to be a practical goal for micro-pattern gas detectors. This white paper outlines the physics case for recoil imaging, and puts forward a decadal plan to advance towards the directional detection of low-energy recoils with sensitivity and resolution close to fundamental performance limits. The science case covered includes: the discovery of dark matter into the neutrino fog, directional detection of sub-MeV solar neutrinos, the precision study of coherent-elastic neutrino-nucleus scattering, the detection of solar axions, the measurement of the Migdal effect, X-ray polarimetry, and several other applied physics goals. We also outline the R&D programs necessary to test concepts that are crucial to advance detector performance towards their fundamental limit: single primary electron sensitivity with full 3D spatial resolution at the $\sim$100 micron-scale. These advancements include: the use of negative ion drift, electron counting with high-definition electronic readout, time projection chambers with optical readout, and the possibility for nuclear recoil tracking in high-density gases such as argon. We also discuss the readout and electronics systems needed to scale-up such detectors to the ton-scale and beyond., 77 pages, 20 figures. Submitted to the Proceedings of the US Community Study on the Future of Particle Physics (Snowmass 2021)

Published
2022

9. Recoil imaging for dark matter, neutrinos, and physics beyond the Standard Model

Author

Ciaran O'Hare, Loomba, D., Altenmuller, K., Alvarez-Pol, H., Amaro, F. D., Araujo, H. M., Aristizabal Sierra, D., Asaadi, J., Attie, D., Aune, S., Awe, C., Ayyad, Y., Baracchini, e, Barbeau, P., Battat, J. B. R., Bell, N. F., Biasuzzi, B., Bignell, L. J., Boehm, C., Bolognino, I., Brunbauer, F. M., Caamano, M., Cabo, C., Caratelli, D., Carmona, J. M., Castel, J. F., Cebrián, S., Cogollos, C., Collison, D., Costa, E., Dafni, T., Dastgiri, F., Deaconu, C., Romeri, V., Desch, K., Dho, G., Di Giambattista, F., Dezibánez, D., D Imperio, G., Dutta, B., Eldridge, C., Elliott, S. R., Ezeribe, A. C., Fava, A., Felkl, T., Fernández-Domnguez, B., Ferrer Ribas, E., Flothner, K. J., Froehlich, M., Galán, J., Galindo, J., Garca, F., Garca Pascual, J. A., Gelli, B. P., Ghrear, M., Giomataris, Y., Gnanvo, K., Gramellini, E., Di Cortona, G. Grilli, Hall-Wilton, R., Harton, J., Hedges, S., Higashino, S., Hill, G., Holanda, P. C., Ikeda, T., Irastorza, I. G., Jackson, P., Janssens, D., Jones, B., Kaminski, J., Katsioulas, I., Kelly, K., Kemmerich, N., Kemp, E., Korandla, H. B., Kraus, H., Lackner, A., Lane, G. J., Lewis, P. M., Lisowska, M., Luzón, G., Lynch, W. A., Maccarrone, G., Mack, K. J., Majewski, P. A., Mano, R. D. P., Margalejo, C., Markoff, D., Marley, T., Marques, D. J. G., Massarczyk, R., Mazzitelli, G., Mccabe, C., Mckie, L. J., Mclean, A. G., Mcnamara, P. C., Mei, Y., Messina, A., Mills, A. F., Mirallas, H., Miuchi, K., Monteiro, C. M. B., Mosbech, M. R., Muller, H., Natal Da Luz, H., Nakamura, K. D., Natochii, A., Neep, T., Newstead, J. L., Nikolopoulos, K., Obis, L., Oliveri, E., Orlandini, G., Ortiz de Solórzano, A., Oy, J., Papaevangelou, T., Pérez, O., Perez-Gonzalez, Y. F., Pfeiffer, D., Phan, N. S., Piacentini, S., Picatoste Olloqui, E., Pinci, D., Popescu, S., Prajapati, A., Queiroz, F. S., Raaf, J. L., Resnati, F., Ropelewski, L., Roque, R. C., Ruiz-Choliz, E., Rusu, A., Ruz, J., Samarati, J., Santos, E. M., Dos Santos, J. M. F., Sauli, F., Scharenberg, L., Schiffer, T., Schmidt, S., Scholberg, K., Schott, M., Schueler, J., Segui, L., Sekiya, H., Sengupta, D., Slavkovska, Z., Snowden-Ifft, D., Soffitta, P., Stenis, M., Spooner, N. J. C., Strigari, L., Stuchbery, A. E., Sun, X., Torelli, S., Tilly, E. G., Thomas, A. W., Thorpe, T. N., Urquijo, P., Utrobicic, A., Vahsen, S. E., Veenhof, R., Vogel, J. K., Williams, A. G., Wood, M. H., and Zettlemoyer, J.

Subjects
Astrophysics and Astronomy, Physics::Instrumentation and Detectors, hep-ex, astro-ph.CO, hep-ph, Detectors and Experimental Techniques, physics.ins-det, Particle Physics - Experiment, Particle Physics - Phenomenology
Abstract

Recoil imaging entails the detection of spatially resolved ionization tracks generated by particle interactions. This is a highly sought-after capability in many classes of detector, with broad applications across particle and astroparticle physics. However, at low energies, where ionization signatures are small in size, recoil imaging only seems to be a practical goal for micro-pattern gas detectors. This white paper outlines the physics case for recoil imaging, and puts forward a decadal plan to advance towards the directional detection of low-energy recoils with sensitivity and resolution close to fundamental performance limits. The science case covered includes: the discovery of dark matter into the neutrino fog, directional detection of sub-MeV solar neutrinos, the precision study of coherent-elastic neutrino-nucleus scattering, the detection of solar axions, the measurement of the Migdal effect, X-ray polarimetry, and several other applied physics goals. We also outline the R&D programs necessary to test concepts that are crucial to advance detector performance towards their fundamental limit: single primary electron sensitivity with full 3D spatial resolution at the $\sim$100 micron-scale. These advancements include: the use of negative ion drift, electron counting with high-definition electronic readout, time projection chambers with optical readout, and the possibility for nuclear recoil tracking in high-density gases such as argon. We also discuss the readout and electronics systems needed to scale-up such detectors to the ton-scale and beyond.

Published
2022

13. Las revistas ante los datos de investigación. Análisis de las soluciones actuales

Author

Peset, Fernanda, Arroyo Guardeño, David, Aleixandre-Benavent, Rafael, Vidal Cabo, C., Ferrer-Sapena, Antonia, Garzón, F., Marín Campos, A., and Polanco, J

Subjects
Research data policies, author's rights, ownership, copyright, copyleft, open access. [ED. Intellectual property], Open research data, Políticas de datos, Datos abiertos, Tendencias, Scientific journals, Trends, HN. e-journals, Revistas científicas, IM. Open data
Abstract

En el ecosistema de la comunicación científica donde lo abierto va tomando posiciones cada vez más decididas (plan S sobre publicación en revistas OA para Europa, desuscripción de la colección electrónica de Elsevier por parte de Suecia…) las revistas se enfrentan a un nuevo reto: asumir la publicación de los datos de investigación que subyacen a un artículo. En la última encuesta de la Danish National Research Foundation (Open Access to data, 2017) el 32 % de los investigadores adjuntan sus datos como material suplementario del artículo; también corroborado por anteriores trabajos (Piwowar y Chapman, 2010). Este poster muestra las ventajas y desventajas. Los autores abogamos por una vía mixta: depositar los datos en un repositorio y establecer un enlace recíproco en el artículo. No tenemos constancia de ninguna revisión sistemática sobre las soluciones tecnológicas que se ofrecen a las revistas para afrontar este reto. Este trabajo tiene como objetivo ofrecer información comparativa sobre las soluciones más integradas con las revistas (como Dataverse, Figshare y Zenodo), con sus funcionalidades y precios a día de hoy. In the ecosystem of scholar communication where the openess is taking increasingly decisive positions (plan S on publication in OA journals for Europe, unsubscription of the electronic collection of Elsevier by Sweden ...) journals face a new challenge: take on the publication of the research data underlying an article. In the latest survey of the Danish National Research Foundation (Open Access to data, 2017) 32% of researchers attach their data as supplementary material to the article and also previous works corroborate this preference (Piwowar and Chapman, 2010). The poster shows pros and cons of the supplementary-material-road (NISO, 2013; Peset, 2018). To minimize the problems we advocate to deposit the data in a repository and establish a reciprocal link in the article. We are not aware of any systematic review of the technological solutions offered to journals to meet this challenge. The aim of this work is to offer comparative information on the solutions most integrated with journals (such as Dataverse, Figshare and Zenodo), with their functionalities and current prices. UCR::Vicerrectoría de Investigación

Published
2019

19. Erratum to: The Intensive Care Global Study on Severe Acute Respiratory Infection (IC‑GLOSSARI): a multicenter, multinational, 14-day inception cohort study (Intensive Care Medicine, (2016), 42, 5, (953), 10.1007/s00134-016-4317-4)

Author

Sakr, Yasser, Ferrer, Ricard, Reinhart, Konrad, Beale, Richard, Rhodes, Andrew, Moreno, Rui, Timsit, Jean Francois, Brochard, Laurent, Thompson, B. Taylor, Rezende, Ederlon, Chiche, Jean Daniel, Auer, J., Schatzl, G., Mach, K., Gruber, H., Schreurs, E., Vander Laenen, M., Ceunen, H., Wauters, J., Francois, G., Deschamps, P., Castanares, D., Debels, D., Pierrakos, C., Vincent, J. L., Taccone, F., Vymazal, T., Gornik, I., Vujiaklija Brajkovic, A., Medici, R., Nielsen, J., Bendtsen, A., Siegel, H., Suonsyrjä, T., Hraech, S., Daviaux, F., Guillot, M., Castelain, V., Losser, R. -R., Novy, E., Bouadma, L., Misset, B., Philippart, F., Mallat, J., Zogheib, E., Miclo, M., Teboul, J. -L., Anguel, N., Darmon, M., Pham, T., Barberet, G., Plantefeve, G., Floccard, B., Kheladze, Z., Bloos, F., Faltlhauser, A., Helmes, T., Zacharowski, K., Meybohm, P., Schwarzkopf, K., Christ, M., Baumgaertel, M., John, S., Nentwich, J., Deja, M., Goldmann, A., Gottschalk, A., Honig, F., Siepe, B., Goebel, U., Lehmke, J., Behrens, S., Fiedler, K., Sagoschen, I., Riessen, R., Haap, M., Simon, Ph., Kaisers, U., Niesen, M., Jaschinski, U., Hoersch, S., Jung, A., Allgaeuer, S., Haake, H., Lange, A., Papanikolaou, M., Balla, M., Giannakou, M., Soultati, I., Nikos, G., Koulouras, V., Kyriazopoulos, G., Gkika, D., Vlachogianni, G., Psaroulis, K., Mouloudi, E., Massa, E., Nichol, A., Meany, E., Motherway, C., Bellani, G., Pota, V., Schiavone, V., Girardis, M., Busani, S., Petrucci, N., Di Pasquale, R., Mazzini, P., Molin, A., Pellerano, G., Volta, C., Spadaro, S., Guarracino, F., Savioli, M., Pellis, T., Chinellato, N., Gatta, A., Cecchini, F., Raineri, S. M., Cortegiani, A., Kekstas, G., Karosas, V., Anguseva, T., Mitrev, Z., Beck, O., Cimic, N., Janssen, G., Bormans, L., Kuiper, M., Koopmans, K., Den Boer, S., de Groot, M., Dennesen, P., van den Bosch, J., Kluge, G., Mikaszewska-Sokolewicz, M., Lazowski, T., Chruscikowski, M., Machon, J., Adamik, B., Kübler, A., Wieczorek, A., Afonso, S., Matos, R., Catorze, N., Araujo, A., Costa, Z., Pais-de-Lacerda, A., Martins, I., Cardiga, R., Fernandes, L., Serra, I., Martinho, A., Tomescu, D., Popescu, M., Scarlatescu, E., Stoica, R., Macri, A., Filipescu, D., Rupnik, E., Tomic, V., Sifrer, F., Sole Violan, J., Ferrer Agüero, J. M., Izura, J., Monedero, P., de Cabo, C. Muños, Aguilar, G., Belda, F. J., Blanquer, J., Nives Carbonell, E., Lopez-Delgado, J. -C., Aragon, C., Joya, C., Ortiz-Leyba, C., Fernandez Gonzalez, C. J., de la Torre-Prados, M. -V., Puerto-Morlan, A., Araujo Aguilar, P., Tomás Marsilla, J. I., Vera Aratcoz, P., Olmo, A., Ferrer Roca, R., Catalan, R. M., Garcia Olivares, P., Albis, A., Alvarez, M., Corcoles Gonzalez, V., Gutierrez Rubio, J. M., Montoiro Allue, R., Rubio Mateo-Sidron, J., Hobrok, M., Cecconi, M., Di Tomasso, N., Raj, A., Szakmany, T., Srinivasa, L., Mathew, S., Ferguson, A., Blahut-Zugaj, M., Watters, M., Henderson, S., Sim, M., Csabi, P., O’Neill, O., Nutt, C., Humphreys, S., Bhowmick, K., Donnelly, A., O’Kane, S., Garfield, M., Jha, R., Unni, N., Gordon, A., Rubulotta, F., Ravi, K., Lunch, G., Franco, F., Higgs, D., Strandvik, G., Jonas, A., Hopkins, Ph., Hurst, T., Bellini, A., Balogun, O., Srinivasan, R., Ostermann, M., Alexander, P., McCalman, K., Bedford, J., Fulop, M., Brescia, G., Strachan, J., Meyer, J., Stotz, M., Brett, S., Zand, F., Nikandish, R., Hashemian, S., Jamaati, H., Alsheikhly, A. S., Almekhlafi, G., Albarrak, M., Maghrabi, A., Salahuddin, N., Aisa, T., Atalan, H. K., Sungur, M., Hegazi, M., Bauer, P., Mukkera, S., Fried, J., Barger, M., Gueret, R., Gonzalez, C., Lovesio, C., Dellera, Ch., Barrios, D., Leite Mendes, C., Gottardo, P., Caser, E., Santos, C., Carvalho, A., Teixeira, C., Samaniego, W., Whittle, S., Molano, D., Rojas, A., Guerra, K., Villamagua, B., Salgado-Yepez, E., Morocho, D., Remache-Vargas, N., Ñamendys-Silva, S., Rodriguez, D., Dominguez, G., Barraza, G., Bermudez-Aceves, E., Sanchez-Hurtado, L. A., Baltazar-Torres, J. A., Quispe Sierra, R., Chavez, C., von Osten, I., Van Haren, C., Smalley, N., Kol, M., Wong, H., Smith, R., Yu, L., Wu, X., Chao, L., Zhai, Q., Wu, D., Zhang, X., Jing, X., Bigornia, R., Ikeda-Maquiling, Y., Robles, J., Palo, J. E., Nguyen, T., Dao, C., Dixit, S., Gurjar, M., Reddy, P., Pravin, A., Simran, S., Ramakrishnan, N., Shetty, R., Udwadia, F., Faraz, M., Indraratna, K., Rajasinhe, J., Sakr, Yasser, Ferrer, Ricard, Reinhart, Konrad, Beale, Richard, Rhodes, Andrew, Moreno, Rui, Timsit, Jean Francoi, Brochard, Laurent, Thompson, B. Taylor, Rezende, Ederlon, Chiche, Jean Daniel, Auer, J., Schatzl, G., Mach, K., Gruber, H., Schreurs, E., Vander Laenen, M., Ceunen, H., Wauters, J., Francois, G., Deschamps, P., Castanares, D., Debels, D., Pierrakos, C., Vincent, J.L., Taccone, F., Vymazal, T., Gornik, I., Vujiaklija Brajkovic, A., Medici, R., Nielsen, J., Bendtsen, A., Siegel, H., Suonsyrjä, T., Hraech, S., Daviaux, F., Guillot, M., Castelain, V., Losser, R.-R., Novy, E., Bouadma, L., Misset, B., Philippart, F., Mallat, J., Zogheib, E., Miclo, M., Teboul, J.-L., Anguel, N., Darmon, M., Pham, T., Barberet, G., Plantefeve, G., Floccard, B., Kheladze, Z., Bloos, F., Faltlhauser, A., Helmes, T., Zacharowski, K., Meybohm, P., Schwarzkopf, K., Christ, M., Baumgaertel, M., John, S., Nentwich, J., Deja, M., Goldmann, A., Gottschalk, A., Honig, F., Siepe, B., Goebel, U., Lehmke, J., Behrens, S., Fiedler, K., Sagoschen, I., Riessen, R., Haap, M., Simon, Ph., Kaisers, U., Niesen, M., Jaschinski, U., Hoersch, S., Jung, A., Allgaeuer, S., Haake, H., Lange, A., Papanikolaou, M., Balla, M., Giannakou, M., Soultati, I., Nikos, G., Koulouras, V., Kyriazopoulos, G., Gkika, D., Vlachogianni, G., Psaroulis, K., Mouloudi, E., Massa, E., Nichol, A., Meany, E., Motherway, C., Bellani, G., Pota, V., Schiavone, V., Girardis, M., Busani, S., Petrucci, N., Di Pasquale, R., Mazzini, P., Molin, A., Pellerano, G., Volta, C., Spadaro, S., Guarracino, F., Savioli, M., Pellis, T., Chinellato, N., Gatta, A., Cecchini, F., Raineri, S.M., Cortegiani, A., Kekstas, G., Karosas, V., Anguseva, T., Mitrev, Z., Beck, O., Cimic, N., Janssen, G., Bormans, L., Kuiper, M., Koopmans, K., Den Boer, S., de Groot, M., Dennesen, P., van den Bosch, J., Kluge, G., Mikaszewska-Sokolewicz, M., Lazowski, T., Chruscikowski, M., Machon, J., Adamik, B., Kübler, A., Wieczorek, A., Afonso, S., Matos, R., Catorze, N., Araujo, A., Costa, Z., Pais-de-Lacerda, A., Martins, I., Cardiga, R., Fernandes, L., Serra, I., Martinho, A., Tomescu, D., Popescu, M., Scarlatescu, E., Stoica, R., Macri, A., Filipescu, D., Rupnik, E., Tomic, V., Sifrer, F., Sole Violan, J., Ferrer Agüero, J.M., Izura, J., Monedero, P., de Cabo, C. Muño, Aguilar, G., Belda, F.J., Blanquer, J., Nives Carbonell, E., Lopez-Delgado, J.-C., Aragon, C., Joya, C., Ortiz-Leyba, C., Fernandez Gonzalez, C.J., de la Torre-Prados, M.-V., Puerto-Morlan, A., Araujo Aguilar, P., Tomás Marsilla, J.I., Vera Aratcoz, P., Olmo, A., Ferrer Roca, R., Catalan, R.M., Garcia Olivares, P., Albis, A., Alvarez, M., Corcoles Gonzalez, V., Gutierrez Rubio, J.M., Montoiro Allue, R., Rubio Mateo-Sidron, J., Hobrok, M., Cecconi, M., Di Tomasso, N., Raj, A., Szakmany, T., Srinivasa, L., Mathew, S., Ferguson, A., Blahut-Zugaj, M., Watters, M., Henderson, S., Sim, M., Csabi, P., O’Neill, O., Nutt, C., Humphreys, S., Bhowmick, K., Donnelly, A., O’Kane, S., Garfield, M., Jha, R., Unni, N., Gordon, A., Rubulotta, F., Ravi, K., Lunch, G., Franco, F., Higgs, D., Strandvik, G., Jonas, A., Hopkins, Ph., Hurst, T., Bellini, A., Balogun, O., Srinivasan, R., Ostermann, M., Alexander, P., McCalman, K., Bedford, J., Fulop, M., Brescia, G., Strachan, J., Meyer, J., Stotz, M., Brett, S., Zand, F., Nikandish, R., Hashemian, S., Jamaati, H., Alsheikhly, A.S., Almekhlafi, G., Albarrak, M., Maghrabi, A., Salahuddin, N., Aisa, T., Atalan, H.K., Sungur, M., Hegazi, M., Bauer, P., Mukkera, S., Fried, J., Barger, M., Gueret, R., Gonzalez, C., Lovesio, C., Dellera, Ch., Barrios, D., Leite Mendes, C., Gottardo, P., Caser, E., Santos, C., Carvalho, A., Teixeira, C., Samaniego, W., Whittle, S., Molano, D., Rojas, A., Guerra, K., Villamagua, B., Salgado-Yepez, E., Morocho, D., Remache-Vargas, N., Ñamendys-Silva, S., Rodriguez, D., Dominguez, G., Barraza, G., Bermudez-Aceves, E., Sanchez-Hurtado, L.A., Baltazar-Torres, J.A., Quispe Sierra, R., Chavez, C., von Osten, I., Van Haren, C., Smalley, N., Kol, M., Wong, H., Smith, R., Yu, L., Wu, X., Chao, L., Zhai, Q., Wu, D., Zhang, X., Jing, X., Bigornia, R., Ikeda-Maquiling, Y., Robles, J., Palo, J.E., Nguyen, T., Dao, C., Dixit, S., Gurjar, M., Reddy, P., Pravin, A., Simran, S., Ramakrishnan, N., Shetty, R., Udwadia, F., Faraz, M., Indraratna, K., and Rajasinhe, J.

Subjects
Critical Care and Intensive Care Medicine
Abstract

In both the original publication (DOI 10.1007/s00134-015-4206-2) and the first erratum (DOI 10.1007/s00134-016-4317-4), the members of the IC-GLOSSARI Investigators and the ESICM Trials Group were provided in such a way that they could not be indexed as collaborators on PubMed. The publisher apologizes for these errors and is pleased to list the members of the groups here: (Table presented.).

Published
2018

40. FTIR study of gas-phase alcohols photocatalytic degradation with TiO2 and AC-TiO2

Author

Araña, J., Doña-Rodríguez, J.M., Cabo, C. Garriga i, González-Díaz, O., Herrera-Melián, J.A., and Pérez-Peña, J.

Subjects
*PHOTOCATALYSIS, *ACTIVATED carbon, *CHEMICAL inhibitors, *METHANOL
Abstract

In this paper the degradation of gaseous alcohols (methanol, ethanol, 1-propanol and 1-butanol) has been studied in a continuous reaction system. Methanol and ethanol, but not 1-propanol and 1-butanol, have caused the catalyst bare-TiO2 to become deactivated. The catalyst containing activated carbon, AC-TiO2, has not shown almost deactivation in any experiment.To explain this behaviour variation, a thorough FTIR study concerning the interaction of gaseous alcohols with the catalyst surface and the effect of light on the process was performed. Thus, the interaction of the different catalysts with the selected alcohols, the formed species and the hydroxyl group evolution under irradiation was studied. [Copyright &y& Elsevier]

Published
2004
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41. A new severe mutation in the SLC5A7 gene related to congenital myasthenic syndrome type 20.

Author

Pardal-Fernández, J.M., Carrascosa-Romero, M.C., Álvarez, S., Medina-Monzón, M.C., Caamaño, M. Bengoa, and de Cabo, C.

Subjects
*CONGENITAL myasthenic syndromes, *GENETIC mutation, *ELECTROPHYSIOLOGY, *HETEROZYGOSITY, *DIFFERENTIAL diagnosis
Abstract

Highlights • New case of congenital myasthenic syndrome type 20. Only 8 patients published. • New mutations not described previously, • Very severe form of disease, and poor response to therapy; diagnosis achieved early by repetitive stimulation. Abstract Congenital myasthenic syndromes are a group of genetically determined rare diseases resulting from ultrastructural alterations in synaptic proteins. Up to 32 genes are known to be involved in those syndromes and many mutations have been reported, of which less than 8% affect the presynaptic complex. One of these syndromes is caused by the impairment of the presynaptic sodium-dependent high-affinity choline transporter 1, as a result of a mutation of the SCL5A7 gene associated with congenital myasthenic syndrome type 20 (MIM # 617143). We present a new case of this syndrome, caused by a mutation not previously described. A full term infant presented with acute respiratory failure and generalized weakness. The genetic analysis revealed the patient to be compound heterozygous for a new mutation of the SCL5A7 gene. The genetic analysis of congenital myasthenic syndromes provide information on the ultrastructural underlying mechanisms, which is valuable for differential diagnosis and specific treatments. [ABSTRACT FROM AUTHOR]

Published
2018
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42. Relationship between serum levels of VIP, but not of CGRP, and cranial autonomic parasympathetic symptoms: A study in chronic migraine patients.

Author

Riesco, N., Cernuda-Morollón, E., Martínez-Camblor, P., Pérez-Alvarez, AI, Verano, L., García-Cabo, C., Serrano-Pertierra, E., Pascual, J., and Pérez-Alvarez, A I

Subjects
*SERUM, *PEPTIDES, *VASOACTIVE intestinal peptide, *NEUROTRANSMITTERS, *HEADACHE treatment, *MIGRAINE, *PATIENTS, *AUTONOMIC nervous system diseases, *NEUROPEPTIDES, MIGRAINE complications
Abstract

Background Cranial autonomic parasympathetic symptoms (CAPS) appear in at least half of migraine patients theoretically as a result of the release of peptides by the trigemino-vascular system (TVS). Cranial pain pathways become sensitised by repeated episodes of TVS activation, leading to migraine chronification. Objective The objective of this article is to correlate the presence of CAPS with serum levels of vasoactive intestinal peptides (VIP) and calcitonin gene-related peptide (CGRP). Patients and methods Patients with chronic migraine (CM) were asked about the presence - during migraine attacks - of five CAPS, which were scored from 0 to 10 by using a quantitative scale. Serum VIP and CGRP levels were determined by ELISA. Results We interviewed 87 CM patients (82 females; mean age 44.7 ± 10.6 years). Seventeen had no CAPS, while 70 reported at least one CAPS. VIP levels ranged from 20.8 to 668.2 pg/ml (mean 154.5 ± 123.2). There was a significant positive correlation between scores in the CAPS scale and VIP levels (Spearman correlation coefficient = 0.227; p = 0.035). VIP levels were significantly higher in CM patients by at least one point in the scale vs those with 0 points ( p = 0.002). Analysing symptoms individually, VIP levels were numerically higher in those patients with symptoms, though they were significantly higher only in those patients with lacrimation vs those without it ( p = 0.013). There was no significant correlation between CGRP levels and the score in the CAPS scale. Conclusions Serum VIP, but not CGRP, levels seem to reflect the rate of activation of the parasympathetic arm of the TVS in migraine. [ABSTRACT FROM AUTHOR]

Published
2017
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43. Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study

Author

Ana Vallejo de la Cueva, Pablo T. Aznar, Laura González Cubillo, Chiara Robba, Oriol Plans Galván, Nerea Aretxabala Cortajarena, Robert C. Hyzy, Imen Ben Saida, Jorge Rubio, María José Sánchez Carretero, Katie M. Vance, Blanca Furquet, Irene Patricia Barón Barrera, Sarah J. Peterson, Sara C. LaHue, Sergio Llorente Damas, Andrew R. Vogel, Nihal Patel, Alejandro Suarez-de-la-Rica, Cristina Álvarez, Ricard Molina Latorre, Günseli Orhun, Karen Shephard, Marta Martín Martínez, Paula Castello-Mora, Guillem Navarra-Ventura, Michelle Woodham, Carmen Andrea Sanchis-Veryser, Annachiara Marra, Kristine Nelson, Carolina Ferrer Gómez, Francisco Javier Morán Gallego, Muhammed Elhadi, Sarah Cohen, María Esther Rodriguez Delgado, Rafael Badenes, Isabel Reyes García, Christopher Berkey, Karla Núñez Vázquez, Beata-Gabriela K Simpson, Amaia Quintano Rodero, María Pilar Vicente-Fernández, María Luisa García Pérez, Vanja C. Douglas, María Elena Martínez Quintana, Silvia García de Castrillón i Ramal, Silvia Beretta, Mandeep Sing, Robert A Balk, Yolanda Poveda Hernández, Spencer Roberson, Martin Siegemund, Jordi Morillas Pérez, Rameela Raman, Giuseppe Servillo, João Manoel Silva, Brenda T. Pun, Aurélien Mazeraud, María Cruz Martín Delgado, Borja Hinojal Olmedillo, Gemma Gomà Fernández, Miguel Valente, Michael T. Kenes, Laura Galarza, Fabio Silvio Taccone, Wencong Chen, Rita Pereia, Álvaro Ortega Guerrero, Morgan H. Tandy, Alejandro Ruiz Perea, Stephanie Wilson-Linville, Meri Martin Cerezuela, Salvatore Lucio Cutuli, Carlos A. Calvo, María de las Nieves Noci Moreno, Ariadna Bellès, Elisa Govea Bogossian, Mario Dalorzo González, Eva Álvarez Torres, David Díaz Muñoz, Carla Margarida Teixeira, Emilio del Campo Molina, Sol Fernandez-Gonzalo, Christine Harb, Berta Monleón, Anna Teresa Mazzeo, Beatriz Del Moral Barbudo, Thomas Godet, Cristina Delgado Palacios, C. Adrian Austin, Hilde Wøien, Anselmo Caricato, Erik Roman-Pognuz, Bruno Gonçalves, Patricia Rodríguez Villamizar, Eloisa Sofia Tanzarella, Daniel A Godoy Torres, Robert E. Hosse, Lisa Smit, María Rosa Sanchis-Martin, Cristina Murcia Gubianas, Emily Sanders, Karen Herrera-Davis, Sara Torrico Sánchez, Isabel Peña Luna, David A Bennett, Irene Torres, Diana Gil-Castillejos, Laura Labrador Romero, Felipe González-Seguel, Carlos Muñoz De Cabo, Ellis Morgan, Itziar Insausti, Mónica García Simón, Patricia Piñeiro Otero, Genís Carrasco Gómez, M. Montero, Jose García Cantos, Ignacio Garutti, César Rodriguez Nuñez, Fernando Higuero, Sameep Sehgal, Catherine M. Kuza, Yago García Blanco-Traba, Juan Romeu Prieto, Ainhoa Serrano, Elena Abril Palomares, Perihan Ergin Özcan, Mathieu van der Jagt, Elena Gallego Curto, Berta Gallego Rodríguez, Rosalía Navarro Casado, Aaron Lerner, Myrto Tzimou, Sheila Moya Gutiérrez, Beatriz García Góngora, Eleonora Stival, Xavier Andorrà Sunyer, Susana Gallardo Sánchez, Anna Baró Serra, Filadelfo Bustos Molina, Rafael Zaragoza, Verónica Rojas, Paolo Pelosi, Aris Pérez Lucendo, Stéphane Legriel, Eduardo Tobar, Laura Lizama, Viviane Hidalgo-Calibin, Chiara Maria Concetta Massaro, Nekane Romero, Pablo García Domelo, Isabel Jesus Pereira, Kelly Drumright, Frank Rasulo, Mattia Marchesi, Jacques Creteur, Estefanía Carvajal Revuelta, Timothy D. Girard, Pablo Carreño-Montenegro, Ana Montero Feijoo, Ignacio Baeza Gómez, Alba Gonzalo Millán, Esteban Morcillo, Alice Santos, Pilar Leal Sanz, Dulce Morales, Gabriel Heras La Calle, Hollis R. O’Neal, Antonio Ramírez-Palma, Inés Pérez Francisco, Alberto Noto, Matilde González Serrano, Paola Valls, María Jesús Mármol Cubillo, Emilio Maseda, Anna Estermann, Andrés Pujol, E. Wesley Ely, Alexis Ferré, Lucia Chowdhury, Guillaume Lacave, Cristina Granja, Isabel de la Calle Gil, Onur M Orun, Mohamed Boussarsar, David Pestaña Lagunas, Denise Battaglini, Nathan E. Brummel, Rosa María Pérez Manrique, Núria Zellweger, Jaume Puig, Kiran Devulapally, Milagros Calizaya Vargas, Jesús Caballero, Theresa Olasveengen, Cristina Fuster, Aarti Sarwal, Pratik P. Pandharipande, Gabriele Pintaudi, Paula Ramirez, Blanca Fernández Tomás, Maria Claudia Giménez Santamarina, Francisco Luis Pérez Caballero, Enver Rodriguez-Martinez, David Martínez-Gascueña, Irene Paredes Borrachero, Ugo Fraisse, Paloma LaTorre Andreu, Ignacio Catalán-Monzón, Elena Gonzalez, Figen Esen, Lorenzo Peluso, Intensive Care, Pun, B. T., Badenes, R., Heras La Calle, G., Orun, O. M., Chen, W., Raman, R., Simpson, B. -G. K., Wilson-Linville, S., Hinojal Olmedillo, B., Vallejo de la Cueva, A., van der Jagt, M., Navarro Casado, R., Leal Sanz, P., Orhun, G., Ferrer Gomez, C., Nunez Vazquez, K., Pineiro Otero, P., Taccone, F. S., Gallego Curto, E., Caricato, A., Woien, H., Lacave, G., O'Neal, H. R., Peterson, S. J., Brummel, N. E., Girard, T. D., Ely, E. W., Pandharipande, P. P., Creteur, J., Bogossian, E. G., Peluso, L., Gonzalez-Seguel, F., Hidalgo-Cabalin, V., Carreno-Montenegro, P., Rojas, V., Tobar, E., Ramirez-Palma, A., Herrera-Davis, K., Ferre, A., Legriel, S., Godet, T., Fraisse, U., Goncalves, B., Mazeraud, A., Tzimou, M., Rasulo, F., Beretta, S., Marchesi, M., Robba, C., Battaglini, D., Pelosi, P., Mazzeo, A. T., Noto, A., Servillo, G., Marra, A., Cutuli, S. L., Pintaudi, G., Stival, E., Tanzarella, E. S., Roman-Pognuz, E., Concetta Massaro, C. M., Elhadi, M., Smit, L., Olasveengen, T., Pereira, I. J., Teixeira, C. M., Santos, A., Valente, M., Granja, C., Pereia, R., Silva, J., Furquet, B., Garcia Simon, M., Godoy Torres, D. A., Monleon, B., Morcillo, E., Romero, N., Serrano, A., Torrico Sanchez, S., Perez Caballero, F. L., Pena Luna, I., Baeza Gomez, I., Calizaya Vargas, M., Morillas Perez, J., Carrasco Gomez, G., Molina Latorre, R., Moya Gutierrez, S., Baron Barrera, I. P., Delgado Palacios, C., Garcia Gongora, B., Labrador Romero, L., Galarza, L., Catalan-Monzon, I., Rodriguez-Martinez, E., Murcia Gubianas, C., Belles, A., Rodriguez Delgado, M. E., Caballero, J., Morales, D., Pujol, A., Rubio, J., Alvarez Torres, E., Carvajal Revuelta, E., de la Calle Gil, I., Fernandez Tomas, B., Gallego Rodriguez, B., Gonzalez Serrano, M., LaTorre Andreu, P., Perez Lucendo, A., Abril Palomares, E., Gonzalez Gonzalez, E., Martin Delgado, M. C., Munoz De Cabo, C., Aznar, P. T., Calvo, C. A., Garutti, I., Higuero, F., Martinez-Gascuena, D., Maseda, E., Insausti, I., Montero Feijoo, A., Suarez-de-la-Rica, A., Del Moral Barbudo, B., Garcia Blanco-Traba, Y., Gimenez Santamarina, M. C., Gonzalo Millan, A., Llorente Damas, S., Pestana Lagunas, D., Reyes Garcia, I., Ruiz Perea, A., Ortega Guerrero, A., Marmol Cubillo, M. J., Diaz Munoz, D., Garcia de Castrillon i Ramal, S., Andorra Sunyer, X., Noci Moreno, M. D. L. N., Perez Manrique, R. M., del Campo Molina, E., Martinez Quintana, M. E., Fernandez-Gonzalo, S., Goma Fernandez, G., Navarra-Ventura, G., Baro Serra, A., Fuster, C., Plans Galvan, O., Gil-Castillejos, D., Dalorzo Gonzalez, M., Moran Gallego, F. J., Paredes Borrachero, I., Rodriguez Villamizar, P., Romeu Prieto, J., Sanchez Carretero, M. J., Gallardo Sanchez, S., Bustos Molina, F., Garcia Perez, M. L., Castello-Mora, P., Puig, J., Sanchis-Martin, M. R., Sanchis-Veryser, C. A., Vicente-Fernandez, M. P., Zaragoza, R., Lizama, L., Torres, I., Alvarez, C., Ramirez, P., Martin Cerezuela, M., Montero, M. J., Garcia Cantos, J., Valls, P., Aretxabala Cortajarena, N., Garcia Domelo, P., Gonzalez Cubillo, L., Martin Martinez, M., Perez Francisco, I., Poveda Hernandez, Y., Quintano Rodero, A., Rodriguez Nunez, C., Siegemund, M., Estermann, A., Zellweger, N., Ben Saida, I., Boussarsar, M., Esen, F., Ergin Ozcan, P., Berkey, C., Harb, C., Tandy, M. H., Morgan, E., Shephard, K., Hyzy, R. C., Kenes, M., Nelson, K., Hosse, R. E., Vance, K. M., Austin, C. A., Lerner, A., Sanders, E., Balk, R. A., Bennett, D. A., Vogel, A. R., Chowdhury, L., Devulapally, K., Woodham, M., Cohen, S., Patel, N., Kuza, C. M., Sing, M., Roberson, S., Drumright, K., Sehgal, S., Lahue, S. C., Douglas, V. C., and Sarwal, A.

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, medicine.medical_treatment, covid-19, delirium, Outcomes, Lower risk, Critical Ilness, Task-Force, 03 medical and health sciences, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Intensive-Care-Unit, Intensive care, Settore MED/41 - ANESTESIOLOGIA, medicine, Survivors, 030212 general & internal medicine, Simplified Acute Physiology Score, Mechaniically Ventilated Patients, Epitiomology, Mechanical ventilation, Coma, Intensive-Care-Unit, Mechaniically Ventilated Patients, Clinical practice Guidelines, Critical Ilness, Task-Force, Sedation, ICU, Survivors, Outcomes, Epitiomology, business.industry, covid, Retrospective cohort study, Articles, Clinical practice Guidelines, covid, delirium, 030228 respiratory system, Sedation, ICU, Emergency medicine, Delirium, medicine.symptom, business, Cohort study
Abstract

Background: To date, 750 000 patients with COVID-19 worldwide have required mechanical ventilation and thus are at high risk of acute brain dysfunction (coma and delirium). We aimed to investigate the prevalence of delirium and coma, and risk factors for delirium in critically ill patients with COVID-19, to aid the development of strategies to mitigate delirium and associated sequelae. Methods: This multicentre cohort study included 69 adult intensive care units (ICUs), across 14 countries. We included all patients (aged ≥18 years) admitted to participating ICUs with severe acute respiratory syndrome coronavirus 2 infection before April 28, 2020. Patients who were moribund or had life-support measures withdrawn within 24 h of ICU admission, prisoners, patients with pre-existing mental illness, neurodegenerative disorders, congenital or acquired brain damage, hepatic coma, drug overdose, suicide attempt, or those who were blind or deaf were excluded. We collected de-identified data from electronic health records on patient demographics, delirium and coma assessments, and management strategies for a 21-day period. Additional data on ventilator support, ICU length of stay, and vital status was collected for a 28-day period. The primary outcome was to determine the prevalence of delirium and coma and to investigate any associated risk factors associated with development of delirium the next day. We also investigated predictors of number of days alive without delirium or coma. These outcomes were investigated using multivariable regression. Findings: Between Jan 20 and April 28, 2020, 4530 patients with COVID-19 were admitted to 69 ICUs, of whom 2088 patients were included in the study cohort. The median age of patients was 64 years (IQR 54 to 71) with a median Simplified Acute Physiology Score (SAPS) II of 40·0 (30·0 to 53·0). 1397 (66·9%) of 2088 patients were invasively mechanically ventilated on the day of ICU admission and 1827 (87·5%) were invasively mechanical ventilated at some point during hospitalisation. Infusion with sedatives while on mechanical ventilation was common: 1337 (64·0%) of 2088 patients were given benzodiazepines for a median of 7·0 days (4·0 to 12·0) and 1481 (70·9%) were given propofol for a median of 7·0 days (4·0 to 11·0). Median Richmond Agitation–Sedation Scale score while on invasive mechanical ventilation was –4 (–5 to –3). 1704 (81·6%) of 2088 patients were comatose for a median of 10·0 days (6·0 to 15·0) and 1147 (54·9%) were delirious for a median of 3·0 days (2·0 to 6·0). Mechanical ventilation, use of restraints, and benzodiazepine, opioid, and vasopressor infusions, and antipsychotics were each associated with a higher risk of delirium the next day (all p≤0·04), whereas family visitation (in person or virtual) was associated with a lower risk of delirium (p

Published
2021

44. Estimation of surface roughness and stone cover in burnt soils using SAR images

Author

Menéndez Duarte, R., Wozniak, E., Recondo, C., Cabo, C., Marquínez, J., and Fernández, S.

Subjects
*SURFACE roughness, *SYNTHETIC aperture radar, *SOIL erosion, *FRICTION
Abstract

Abstract: In many quartzitic slopes in the NW of the Iberian Peninsula there is a high topsoil stoniness which produces a random surface roughness. The surface roughness is one of the control parameters in the signal of Synthetic Aperture Radar (SAR) images. In this work we test the use of the SAR images for distinguishing and mapping areas with different surface roughness which, in this study, correspond with areas with different surface stoniness. In accordance with the geographic location, the relief of the study area and the aims of the project JERS and ENVISAT SAR images were used. The images are characterized by the high view angles, between 33° and 42°, alternating polarization (HH/HV, VV/VH) data and ascending and descending passes. In order to describe the soil roughness various measuring methods were applied in plot parcels (direct measurements of height of clasts and laser scanning) and different roughness models were tested. The results show that there are relation between SAR signal (DN) and the soil roughness classes: DN = aθ b and the b parameter is correlated with the roughness. The best fit between roughness model and SAR data was found for mean standard deviation (rms) height of clasts. Once verified that the correlation between SAR signal and surface roughness exists, the ENVISAT images were classified into three successive surface roughness classes. In order to facilitate the classification Principal Components Analysis were carried out over all polarization bands and the object oriented classification was applied. To validate the accuracy of the SAR images classification we elaborated by photointerpretation a surface condition map for an area of 10,700 ha. The SAR classification and photointerpreted map were compared for three classes: surface without stones, surface with stones (low and medium stoniness) and total cover of loose clasts. The overall coincidence between the maps is about 70%. Besides, large areas located in the northwest of the Iberian Peninsula suffer soil degradation caused by wildfires and the increase of surface stoniness is one of the effects described in the postfire erosion. The influence of wildfires and the associated erosion is particularly important on quartzitic slopes partially covered by coarse grain-supported deposits, like the ones considered in this study. The available data for the area of study suggest the high correlation between the different classes of surface roughness and stoniness obtained from SAR imagery, and the gradual different status of postfire soil erosion. [Copyright &y& Elsevier]

Published
2008
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45. Nasal exudate for diagnosis of stroke: fundamental studies through iron fractionation, total iron, and targeted protein determinations.

Author

Marina-Latorre M, Lobo L, García-Cabo C, Benavente-Fernández L, Calleja-Puerta S, Fernández-Abedul MT, González-Iglesias H, and Pereiro R

Subjects
Humans, Male, Female, Chemical Fractionation methods, Enzyme-Linked Immunosorbent Assay methods, Lactoferrin analysis, Middle Aged, Aged, Transferrin analysis, Exudates and Transudates chemistry, Ferritins analysis, Mass Spectrometry methods, Cation Transport Proteins, Ferroportin, Iron analysis, Stroke diagnosis
Abstract

During the last years, there has been an increasing research interest in the analysis of biological fluids requiring non-invasive sampling for biomedical and clinical applications. In this work, we have focused on the nasal exudate with the aim of investigating the potential use of this fluid to know the role of iron in stroke and also for diagnosis. Potential differences in the nasal exudate, collected in swabs, from diagnosed hemorrhagic stroke, ischemic stroke, and control groups were investigated with regard to total iron by inductively coupled plasma-mass spectrometry, iron fractionation studies by size exclusion chromatography together with post-column isotope dilution analysis, and four proteins containing iron (ferritin, transferrin, lactoferrin, and ferroportin) with ELISA kits. All these analyses represent an analytical challenge, considering the rather limited amount of sample (10-40 mg) available, being the nasal exudate extracted from the swab with 300 µL 10 mM Tris/HCl, pH = 7.4. Studies to obtain reliable analytical information, such as the blank contribution of the sampling step, evaluation of the extraction efficiency of the nasal exudate from the swab, and normalization strategies for data treatment, have been carried out. Results showed that despite the limited number of investigated samples, fractionation studies as well as the concentrations of ferritin and ferroportin obtained with ELISA kits showed a differential behavior between the different cohorts., (© 2024. The Author(s).)

Published
2024
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46. Mediterranean Diet Prior to Ischemic Stroke and Potential Circulating Mediators of Favorable Outcomes.

Author

Castañón-Apilánez M, García-Cabo C, Martin-Martin C, Prieto B, Cernuda-Morollón E, Rodríguez-González P, Pineda-Cevallos D, Benavente L, Calleja S, and López-Cancio E

Subjects
Humans, Male, Female, Aged, Middle Aged, Adipokines blood, Endothelial Progenitor Cells metabolism, Prognosis, Resistin blood, Treatment Outcome, Diet, Mediterranean, Ischemic Stroke blood, Biomarkers blood, Olive Oil administration & dosage, Insulin Resistance
Abstract

Background/Objectives . A Mediterranean diet (MD) has been associated with neuroprotective effects. We aimed to assess the MD's association with stroke prognosis and the potential mediators involved. Methods . Seventy patients with acute anterior circulation ischemic stroke were included. Dietary patterns were evaluated using the MEDAS scale, a food-frequency questionnaire, and a 24 h recall. Circulating biomarkers including insulin resistance (HOMA index), adipokines (resistin, adiponectin, leptin), choline pathway metabolites (TMAO, betaine, choline), and endothelial progenitor cells (EPCs) were measured. Early neurological improvement (ENI) at 24 h, final infarct volume, and functional outcome at 3 months were assessed. Results . Adherence to MD and olive oil consumption were associated with a lower prevalence of diabetes and atherothrombotic stroke, and with lower levels of fasting glycemia, hemoglobinA1C, insulin resistance, and TMAO levels. Monounsaturated fatty acids and oleic acid consumption correlated with lower resistin levels, while olive oil consumption was significantly associated with EPC mobilization. Multivariate analysis showed that higher MD adherence was independently associated with ENI and good functional prognosis at 3 months. EPC mobilization, lower HOMA levels, and lower resistin levels were associated with ENI, a smaller infarct volume, and good functional outcome. Conclusions . MD was associated with better prognosis after ischemic stroke, potentially mediated by lower insulin resistance, increased EPC mobilization, and lower resistin levels, among other factors.

Published
2024
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47. General Direct Anticancer Effects of Deer Growing Antler Extract in Several Tumour Cell Lines, and Immune System-Mediated Effects in Xenograft Glioblastoma.

Author

Rossetti A, Chonco L, Alegría N, Zelli V, García AJ, Ramírez-Castillejo C, Tessitore A, de Cabo C, Landete-Castillejos T, and Festuccia C

Abstract

Deer antlers are the fastest growing tissue. Because they are based on proto-oncogenes, to avoid the risk of cancer, antlers evolved strong anticancer mechanisms, and thus their extract (DVA) is effective also against the few human tumours studied so far. We assessed whether DVA is a general anticancer compound by testing the direct effects in cells of different tumours: glioblastoma (GBM; lines U87MG and U251), colorectal (CRC; lines DLD-1, HT-29, SW480, and SW620), breast cancer (BRCA; lines MCF7, SKBR3, and PA00), and leukaemia (THP-1). DVA reduced the viability of tumours but not healthy cells (NHC; lines 293T and HaCaT). Mobility decreased at least for the longest test (72 h). Intraperitoneal/oral 200 mg DVA/kg administration in GBM xenograft mice for 28 d reduced tumour weight by 66.3% and 61.4% respectively, and it also reduced spleen weight (43.8%). In addition, tumours treated with DVA showed symptoms of liquefactive necrosis. Serum cytokines showed DVA up-regulated factors related to tumour fighting and down-regulated those related to inducing immune tolerance to the tumour. DVA shows general anticancer effects in the lines tested and, in GBM mice, also strong indirect effects apparently mediated by the immune system. DVA may contain a future anticancer medicine without secondary effects.

Published
2024
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48. A Handheld Laser-Scanning-Based Methodology for Monitoring Tree Growth in Chestnut Orchards.

Author

Pereira-Obaya D, Cabo C, Ordóñez C, and Rodríguez-Pérez JR

Subjects
Lasers, Light, Trees, Algorithms
Abstract

Chestnut and chestnut byproducts are of worldwide interest, so there is a constant need to develop faster and more accurate monitoring techniques. Recent advances in simultaneous localization and mapping (SLAM) algorithms and user accessibility have led to increased use of handheld mobile laser scanning (HHLS) in precision agriculture. We propose a tree growth monitoring methodology, based on HHLS point cloud processing, that calculates the length of branches through spatial discretization of the point cloud for each tree. The methodology was tested by comparing two point clouds collected almost simultaneously for each of a set of sweet chestnut trees. The results obtained indicated that our HHLS method was reliable and accurate in efficiently monitoring sweet chestnut tree growth. The same methodology was used to calculate the growth of the same set of trees over 37 weeks (from spring to winter). Differences in week 0 and week 37 scans showed an approximate mean growth of 0.22 m, with a standard deviation of around 0.16 m reflecting heterogeneous tree growth.

Published
2024
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49. Measurement of GFAP in Nasal Exudate in the Differential Diagnosis between Ischemic Stroke and Intracerebral Hemorrhage.

Author

García-Cabo C, Rioboó-Legaspi P, Benavente-Fernández L, Costa-Rama E, Fernández-Abedul MT, and Calleja-Puerta S

Subjects
Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Diagnosis, Differential, Exudates and Transudates chemistry, Predictive Value of Tests, Up-Regulation, Biomarkers blood, Cerebral Hemorrhage diagnosis, Cerebral Hemorrhage blood, Cerebral Hemorrhage diagnostic imaging, Glial Fibrillary Acidic Protein blood, Glial Fibrillary Acidic Protein analysis, Ischemic Stroke diagnosis, Ischemic Stroke blood, Ischemic Stroke metabolism
Abstract

Background: Differential diagnosis between ischemic stroke (IS) and intracerebral hemorrhage (ICH) is a great challenge. Recently, the discovery of cerebral lymphatic drainage toward the nostrils suggested nasal exudate (NE) as a new source for measuring biomarkers from neural damage., Objectives: In this study, we sought to confirm whether glial fibrillary acidic protein (GFAP) levels in NE could identify ICH., Methods: GFAP in nasal exudate (nGFAP) was studied in 5 IS and 5 ICH patients. All patients underwent neurological examination, brain computed tomography, laboratory tests, and measurement of nGFAP and serum GFAP., Results: We found higher concentrations in ICH patients (p = 0.02). The area under the ROC curve for IS/ICH discrimination was 0.840, with a cut-off point of 0.06 pg/mg for 100% sensitivity and 80% specificity., Conclusions: These findings suggest that nGFAP could be a useful biomarker for differential diagnosis between IS and ICH and opens a potential field of study for other biomarkers in NE in neurological disorders., (© 2023 S. Karger AG, Basel.)

Published
2024
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50. Palladium nanoclusters as a label to determine GFAP in human serum from donors with stroke by bimodal detection: inductively coupled plasma-mass spectrometry and linear sweep voltammetry.

Author

Rodríguez-Penedo A, Costa-Rama E, Fernández B, García-Cabo C, Benavente L, Calleja S, Fernández-Abedul MT, and Pereiro R

Subjects
Humans, Glial Fibrillary Acidic Protein, Enzyme-Linked Immunosorbent Assay, Mass Spectrometry, Palladium, Stroke diagnosis
Abstract

Water-soluble, stable, and monodisperse palladium nanoclusters (PdNCs) were synthesized using NaBH 4 as a reductant and lipoic acid as a ligand. PdNCs, measured by high-resolution transmission electron microscopy, showed a round shape and a diameter of 2.49 ± 0.02 nm. It was found that each PdNC contains 550 Pd atoms on average. These PdNCs offer high amplification as a label of biochemical reactions when inductively coupled plasma-mass spectrometry (ICP-MS) is used as a detector. In addition, PdNCs have catalytic activity on electrochemical reactions, allowing detection by linear sweep voltammetry (LSV). As a proof of applicability, a competitive immunoassay based on PdNC labels was developed for the determination of glial fibrillary acidic protein (GFAP) in human serum, comparing ICP-MS and LSV detection. GFAP is a biomarker for differentiating between patients with ischemic stroke (IS) and hemorrhagic stroke (HS). The limit of detection (LoD), corresponding to IC 10 (4-parameter logistic curve), was 0.03 pM of GFAP, both by ICP-MS and LSV, being lower than the 0.31 pM LoD provided by the ELISA commercial kit. Using the error profile method, 0.03 pM and 0.11 pM LoDs were obtained respectively by ICP-MS and LSV: LoD is lower by ICP-MS due to the better precision of the measurements. The analyses of human serum samples from IS, HS, and control (CT) donors using PdNC labels and detection by ICP-MS and LSV were validated with a commercial ELISA kit (for CT donors only ICP-MS provided enough sensitivity). Results point out toward the future use of PdNCs as a label in other immunoprobes for the determination of specific proteins requiring very low LoDs as well as the development of electrochemical decentralized methodologies., (© 2023. The Author(s).)

Published
2023
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