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219 results on '"CUOMO, O."'

4. miR135a administration ameliorates brain ischemic damage by preventing TRPM7 activation during brain ischemia.

Author

Cepparulo, P., Brancaccio, P., Sirabella, R., Anzilotti, S., Guida, N., Laudati, G., Valsecchi, V., Vinciguerra, A., Viscardi, V., D'Esposito, L., Formisano, L., Annunziato, L., Pignataro, G., and Cuomo, O.

Subjects
CEREBRAL ischemia, BRAIN damage, ARTERIAL occlusions, CEREBRAL arteries, THERAPEUTICS
Abstract

Background: miRNA‐based strategies have recently emerged as a promising therapeutic approach in several neurodegenerative diseases. Unregulated cation influx is implicated in several cellular mechanisms underlying neural cell death during ischemia. The brain constitutively active isoform of transient receptor potential melastatin 7 (TRPM7) represents a glutamate excitotoxicity‐independent pathway that significantly contributes to the pathological Ca2+ overload during ischemia. Aims: In the light of these premises, inhibition of TRPM7 may be a reasonable strategy to reduce ischemic injury. Since TRPM7 is a putative target of miRNA135a, the aim of the present paper was to evaluate the role played by miRNA135a in cerebral ischemia. Therefore, the specific objectives of the present paper were: (1) to evaluate miR135a expression in temporoparietal cortex of ischemic rats; (2) to investigate the effect of the intracerebroventricular (icv) infusion of miR135a on ischemic damage and neurological functions; and (3) to verify whether miR135a effects may be mediated by an alteration of TRPM7 expression. Methods: miR135a expression was evaluated by RT‐ PCR and FISH assay in temporoparietal cortex of ischemic rats. Ischemic volume and neurological functions were determined in rats subjected to transient middle cerebral artery occlusion (tMCAo) after miR135a intracerebroventricular perfusion. Target analysis was performed by Western blot. Results: Our results demonstrated that, in brain cortex, 72 h after ischemia, miR135a expression increased, while TRPM7 expression was parallelly downregulated. Interestingly, miR135a icv perfusion strongly ameliorated the ischemic damage and improved neurological functions, and downregulated TRPM7 protein levels. Conclusions: The early prevention of TRPM7 activation is protective during brain ischemia. [ABSTRACT FROM AUTHOR]

Published
2024
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6. A Bayesian methodology to improve prediction of early graft loss after liver transplantation derived from the Liver Match study

Author

Angelico, M., Cillo, U., Fagiuoli, S., Strazzabosco, M., Caraceni, P., Toniutto, P.L., Nanni Costa, A., Salizzoni, Torino M., Romagnoli, R., Bertolotti, G., Patrono, D., De Carlis, L., Slim, A., Mangoni, J.M.E., Rossi, G., Caccamo, L., Antonelli, B., Mazzaferro, V., Regalia, E., Sposito, C., Colledan, M., Corno, V., Tagliabue, F., Marin, S., Vitale, A., Gringeri, E., Donataccio, M., Donataccio, D., Baccarani, U., Lorenzin, D., Bitetto, D., Valente, U., Gelli, M., Cupo, P., Gerunda, G.E., Rompianesi, G., Pinna, A.D., Grazi, G.L., Cucchetti, A., Zanfi, C., Risaliti, A., Faraci, M.G., Tisone, G., Anselmo, A., Lenci, I., Sforza, D., Agnes, S., Di Mugno, M., Avolio, A.W., Ettorre, G.M., Miglioresi, L., Vennarecci, G., Berloco, P., Rossi, M., Ginanni Corradini, S., Molinaro, A., Calise, F., Scuderi, V., Cuomo, O., Migliaccio, C., Lupo, L., Notarnicola, G., Gridelli, B., Volpes, R., Li Petri, S., Zamboni, F., Carbotta, G., Dedola, S., Nardi, A., Marianelli, T., Gavrila, C., Ricci, A., Vespasiano, F., Angelico, Mario, Nardi, Alessandra, Romagnoli, Renato, Marianelli, Tania, Corradini, Stefano Ginanni, Tandoi, Francesco, Gavrila, Caius, Salizzoni, Mauro, Pinna, Antonio D., Cillo, Umberto, Gridelli, Bruno, De Carlis, Luciano G., Colledan, Michele, Gerunda, Giorgio E., Costa, Alessandro Nanni, and Strazzabosco, Mario

Published
2014
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13. GATA3 (GATA-binding protein 3)/KMT2A (lysine-methyltransferase-2A) complex by increasing H3K4-3me (trimethylated lysine-4 of histone-3) upregulates NCX3 (Na+-Ca2+exchanger 3) transcription and contributes to ischemic preconditioning neuroprotection

Author

Guida N., Mascolo L., Serani A., Cuomo O., Anzilotti S., Brancaccio P., Pignataro G., Molinaro P., Annunziato L., Formisano L., Guida, N., Mascolo, L., Serani, A., Cuomo, O., Anzilotti, S., Brancaccio, P., Pignataro, G., Molinaro, P., Annunziato, L., and Formisano, L.

Subjects
Histone, Ischemic preconditioning, Neuroprotection oxygen, Methyltransferase
Abstract

BACKGROUND AND PURPOSE: NCX3 (Na+-Ca2+ exchanger 3) plays a relevant role in stroke; indeed its pharmacological blockade or its genetic ablation exacerbates brain ischemic damage, whereas its upregulation takes part in the neuroprotection elicited by ischemic preconditioning. To identify an effective strategy to induce an overexpression of NCX3, we examined transcription factors and epigenetic mechanisms potentially involved in NCX3 gene regulation. METHODS: Brain ischemia and ischemic preconditioning were induced in vitro by exposure of cortical neurons to oxygen and glucose deprivation plus reoxygenation (OGD/Reoxy) and in vivo by transient middle cerebral artery occlusion. Western blot and quantitative real-time polymerase chain reaction were used to evaluate transcripts and proteins of GATA3 (GATA-binding protein 3), KMT2A (lysine-methyltransferase-2A), and NCX3. GATA3 and KMT2A binding on NCX3 gene was evaluated by chromatin immunoprecipitation and Rechromatin immunoprecipitation experiments. RESULTS: Among the putative transcription factors sharing a consensus sequence on the ncx3 brain promoter region, GATA3 was the only able to up-regulate ncx3. Interestingly, GATA3 physically interacted with KMT2A, and their overexpression or knocking-down increased or downregulated NCX3 mRNA and protein, respectively. Notably, site-direct mutagenesis of GATA site on ncx3 brain promoter region counteracted GATA3 and KMT2A binding on NCX3 gene. More importantly, we found that in the perischemic cortical regions of preconditioned rats GATA3 recruited KMT2A and the complex H3K4-3me (trimethylated lysine-4 of histone-3) on ncx3 brain promoter region, thus reducing transient middle cerebral artery occlusion–induced damage. Consistently, in vivo silencing of either GATA3 or KMT2A prevented NCX3 upregulation and consequently the neuroprotective effect of preconditioning stimulus. The involvement of GATA3/KMT2A complex in neuroprotection elicited by ischemic preconditioning was further confirmed by in vitro experiments in which the knocking-down of GATA3 and KMT2A reverted the neuroprotection induced by NCX3 overexpression in cortical neurons exposed to anoxic preconditioning followed by oxygen and glucose deprivation plus reoxygenation. CONCLUSIONS: Collectively, our results revealed that GATA3/KMT2A complex epigenetically activates NCX3 gene transcription during ischemic preconditioning.

Published
2021

21. Worse Graft Survival in HCV-Infected Transplanted Females Receiving a Male Donor Graft. The Liver Match Study.: Abstract# O-164

Author

Romagnoli, R., Rossi, M., Gerunda, G. E., Pinna, A. D., Agnes, S., Spada, M., Colledan, M., Tisone, G., De Carlis, L., Baccarani, U., Ettorre, G. M., Cillo, U., Calise, F., Caccamo, L., Cuomo, O., Lupo, L., Corradini, S., Zamboni, F, Marianelli, T., Risaliti, A., Patrono, D., Petri, S. Li, Tagliabue, F., Mangoni, J. M.E., Antonelli, B., Sposito, C., Gringeri, E., Rompianesi, G., Sforza, D., Cucchetti, A., Miglioresi, L., Donataccio, M., Gelli, M., Gavrila, C., Nardi, A., and Angelico, M.

Published
2012

22. The UN-SUSTAINABLE Match in HCV Recipients. Evidences from the Italian D-MELD Study on Balancing Donor-Recipient Risk Factors.: Abstract# O-162

Author

Avolio, A. W., Agnes, S., Lirosi, M., Salizzoni, M., Pinna, A., Gridelli, B., De Carlis, L., Colledan, M., Gerunda, G., Rossi, G., Ettorre, G., Risaliti, A., Mazzaferro, V., Rossi, M., Tisone, G., Zamboni, F., Lupo, L., Cuomo, O., Calise, F., Donataccio, M., Nicolotti, N., Romagnoli, R., Vitale, A., Cucchetti, A., Gruttadauria, S., Baccarani, U., Caccamo, L., Mangoni, I., Pinelli, D., Montalti, R., Morelli, N., Vennarecci, G., Nicolini, D., Regalia, E., Lai, Q., Anselmo, A., Tondolo, E., Perrella, A., Burra, P., and Cillo, U.

Published
2012

23. Behind D-MELD: The Role of Primary Indication (HCV or HBV) as Significant Covariate in the Outcome Prediction after Liver Transplants.: Abstract# 1672: Poster Board #-Session: P234-IV

Author

Avolio, A. W., Agnes, S., Lirosi, M. C., Salizzoni, M., Pinna, A., Gridelli, B., De Carlis, L., Colledan, M., Gerunda, G., Valente, U., Rossi, G., Ettorre, G., Risaliti, A., Mazzaferro, V., Rossi, M., Tisone, G., Zamboni, F., Lupo, L., Cuomo, O., Calise, F., Nicolotti, N., Vitale, A., Romagnoli, R., Cucchetti, A., Gruttadauria, S., Mangoni, I., Pinelli, D., Montalti, R., Gelli, M., Caccamo, L., Vennarecci, G., Nicolini, D., Regalia, E., Baccarani, U., Lai, Q., Manzia, T., Tondolo, E., Rendina, M., Perrella, A., Scuderi, E., Burra, P., Gasbarrini, A., and Cillo, U.

Published
2012

24. www.D-MELD.com. THE ONLINE PROGNOSTIC CALCULATOR TO OPTIMIZE DONOR-RECIPIENT MATCH: O-123

Author

Avolio, A. W., Agnes, S., Lirosi, M. C., Salizzoni, M., Pinna, A. D., Gridelli, B., De Carlis, L., Colledan, M., Gerunda, G. E., Valente, U., Rossi, G., Ettorre, G. M., Risaliti, A., Mazzaferro, V., Bresadola, F., Rossi, M., Tisone, G., Zamboni, F., Lupo, L., Cuomo, O., Calise, F., Donataccio, M., Nicolotti, N., Vitale, A., Romagnoli, R, Lupo, F., Cucchetti, A., Gruttadauria, S., Mangoni, I., Pinelli, D., Montalti, R, Gelli, M., Caccamo, L., Vennarecci, G., Nicolini, D., Regalia, E., Baccarani, U., Lai, Q., Manzia, T, Tondolo, E., Rendina, M., Perrella, A., Scuderi, E., Antonelli, B., de Waure, C., De Feo, T, Burra, P., Gasbarrini, A., and Cillo, U.

Published
2011

25. List of contributors

Author

Arbitrio, M., Badalamenti, G., Barraco, N., Bazan, V., Bono, M., Brando, C., Busuito, G., Buttitta, F., Calcara, K., Cancelliere, D., Capoluongo, E., Caracciolo, D., Castiglia, M., Cordua, A., Cuomo, O., Cusenza, S., Cutaia, S., Del Re, M., Di Martino, M.T., D’Apolito, M., Fanale, D., Felicioni, L., Fiorillo, L., Fiorino, A., Galvano, A., Giordano, A., Giurintano, A., Greco, M., Gristina, V., Iacono, F., Incorvaia, L., La Mantia, M., Lianidou, E., Malapelle, U., Marchetti, A., Navicella, A., Pedone, E., Perez, A., Pisapia, P., Pivetti, A., Rolfo, C., Rossetti, R., Russo, A., Scalia, R., Spinnato, V., Staropoli, N., Tagliaferri, P., Tassone, P., Taverna, S., Troncone, G., and Uppolo, V.

Published
2023
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31. D-MELD, a Powerful Instrument To Optimize Donor-2-Recipient Match. Differences between US and Italy

Author

Avolio A, Halldorson J, Lirosi M, Agnes S, Salizzoni M, Pinna A, Spada M, De Carlis L, Colledan M, Gerunda G, Andorno E, Rossi G, Ettorre G, Risaliti A, Mazzaferro V, Rossi M, Tisone G, Zamboni F, Vivarelli M, Lupo L, Cuomo O, Calise F, Nicolotti N, Vitale A, Romagnoli R, Cucchetti A, Bonsignore P, Mangoni I, Pinelli D, Montalti R, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Perrella A, Santaniello W, Bottino G, Spagnoletti G, Mariano G, Gasbarrini A, Burra P, Cillo U, Avolio, A, Halldorson, J, Lirosi, M, Agnes, S, Salizzoni, M, Pinna, A, Spada, M, De Carlis, L, Colledan, M, Gerunda, G, Andorno, E, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Rossi, M, Tisone, G, Zamboni, F, Vivarelli, M, Lupo, L, Cuomo, O, Calise, F, Nicolotti, N, Vitale, A, Romagnoli, R, Cucchetti, A, Bonsignore, P, Mangoni, I, Pinelli, D, Montalti, R, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Santaniello, W, Bottino, G, Spagnoletti, G, Mariano, G, Gasbarrini, A, Burra, P, and Cillo, U

Subjects
Transplantation, Surgery
Published
2013

32. The UN-SUSTAINABLE Match in HCV Recipients. Evidences from the Italian D-MELD Study on Balancing Donor-Recipient Risk Factors

Author

Avolio, A. W., Agnes, S., Lirosi, M., Salizzoni, M., Pinna, A., Gridelli, B., Carlis, L., Colledan, M., Gerunda, G., Rossi, G., Ettorre, G., Risaliti, A., Mazzaferro, V., Rossi, M., Tisone, G., Zamboni, F., Lupo, L., Cuomo, O., Calise, F., Donataccio, M., Nicolotti, N., Romagnoli, R., Vitale, A., Cucchetti, A., Gruttadauria, S., Baccarani, U., Caccamo, L., Mangoni, I., Pinelli, D., Montalti, R., Morelli, N., Vennarecci, G., Nicolini, D., Regalia, E., Lai, Q., Alessandro Anselmo, Tondolo, E., Perrella, A., Burra, P., Cillo, U., Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Donataccio, M, Nicolotti, N, Romagnoli, R, Vitale, A, Cucchetti, A, Gruttadauria, S, Baccarani, U, Caccamo, L, Mangoni, I, Pinelli, D, Montalti, R, Morelli, N, Vennarecci, G, Nicolini, D, Regalia, E, Lai, Q, Anselmo, A, Tondolo, E, Perrella, A, Burra, P, and Cillo, U

Subjects
Transplantation, D-MELD, donor-recipient match, liver transplantation, Hepatology, Gastroenterology, Surgery
Published
2012

33. Worse Graft Survival in HCV-Infected Transplanted Females Receiving a Male Donor Graft. The Liver Match Study

Author

Romagnoli, R., Rossi, M., Gerunda, G. E., Pinna, A. D., Agnes, S., Marco Spada, Colledan, M., Tisone, G., Carlis, L., Baccarani, U., Ettorre, G. M., Cillo, U., Calise, F., Caccamo, L., Cuomo, O., Lupo, L., Corradini, S., Zamboni, F., Marianelli, T., Risaliti, A., Patrono, D., Petri, S. Li, Tagliabue, F., Mangoni, J. M. E., Antonelli, B., Sposito, C., Gringeri, E., Rompianesi, G., Sforza, D., Cucchetti, A., Miglioresi, L., Donataccio, M., Gelli, M., Gavrila, C., Nardi, A., Angelico, M., Romagnoli, R, Rossi, M, Gerunda, G, Pinna, A, Agnes, S, Spada, M, Colledan, M, Tisone, G, De Carlis, L, Baccarani, U, Ettorre, G, Cillo, U, Calise, F, Caccamo, L, Cuomo, O, Lupo, L, Corradini, S, Zamboni, F, Marianelli, T, Risaliti, A, Patrono, D, Petri, S, Tagliabue, F, Mangoni, J, Antonelli, B, Sposito, C, Gringeri, E, Rompianesi, G, Sforza, D, Cucchetti, A, Miglioresi, L, Donataccio, M, Gelli, M, Gavrila, C, Nardi, A, and Angelico, M

Subjects
HCV infection, liver transplantation, Transplantation, Hepatology, HCV-infected transplanted females, Gastroenterology, Surgery
Published
2012

34. The Un-sustainable Match In Hcv Liver Transplant Patients

Author

Avolio, Aw, Agnes, S, Lirosi, Mc, Salizzoni, Mauro, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Vitale, A, Nicolotti, N, Romagnoli, Renato, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scuderi, E, Antonelli, B, de Waure, C, Angelico, M, Burra, P, Gasbarrini, A, Cillo, U., Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Vitale, A, Nicolotti, N, Romagnoli, R, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scuderi, E, Antonelli, B, de Waure, C, Angelico, M, Burra, P, Gasbarrini, A, and Cillo, U

Subjects
Liver transplantation, donor-recipient match, liver transplantation
Published
2012

35. Behind D-MELD: The Role of Primary Indication (HCV or HBV) as Significant Covariate in the Outcome Prediction after Liver Transplants

Author

Avolio AW, Agnes S, Lirosi MC, Salizzoni M, Pinna A, Gridelli B, De Carlis L, Colledan M, Gerunda G, Valente U, Rossi G, Ettorre G, Risaliti A, Mazzaferro V, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Nicolotti N, Vitale A, Romagnoli R, Cucchetti A, Gruttadauria S, Mangoni I, Pinelli D, Montalti R, Gelli M, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Perrella A, Scuderi E, Burra P, Gasbarrini A, Cillo U, Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Nicolotti, N, Vitale, A, Romagnoli, R, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scuderi, E, Burra, P, Gasbarrini, A, and Cillo, U

Subjects
liver transplantation, D-MELD
Published
2012

36. www.D-MELD.com. THE ONLINE PROGNOSTIC CALCULATOR TO OPTIMIZE DONOR-RECIPIENT MATCH

Author

Avolio, A. W., Agnes, S., Lirosi, M. C., Salizzoni, M., Pinna, A. D., Gridelli, B., Carlis, L. D., Colledan, M., Gerunda, G. E., Valente, U., Rossi, G., Ettorre, G. M., Risaliti, A., Mazzaferro, V., Bresadola, F., Rossi, M., Tisone, G., Zamboni, F., Lupo, L., Cuomo, O., Calise, F., Donataccio, M., Nicolotti, N., Vitale, A., Romagnoli, R., Lupo, F., Cucchetti, A., Gruttadauria, S., Mangoni, I., Pinelli, D., Montalti, R., Gelli, M., Caccamo, L., Vennarecci, G., Nicolini, D., Regalia, E., Baccarani, U., Lai, Q., Manzia, T., Tondolo, E., Rendina, M., Perrella, A., Scuderi, E., Antonelli, B., Waure, C. d., Feo, T. D., Burra, Patrizia, Gasbarrini, A., Cillo, Umberto, Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Donataccio, M, Nicolotti, N, Vitale, A, Romagnoli, R, Lupo, F, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scuderi, E, Antonelli, B, de Waure, C, De Feo, T, Burra, P, Gasbarrini, A, and Cillo, U

Subjects
Transplantation, liver transplantation, Surgery, D-MELD
Published
2011

37. Www.d-meld.com the Prognostic Calculator To Balance Donor and Recipient Liver Transplant Factors Using D-meld and Covariates

Author

Avolio, Aw, Agnes, S, Lirosi, Mc, Salizzoni, Mauro, Pinna, Ad, Gridelli, B, Decarlis, L, Colledan, M, Gerunda, Ge, Valente, U, Rossi, G, Ettorre, Gm, Risaliti, A, Mazzaferro, V, Rossi, M, Tisone, G, Zamboni, F, Cuomo, O, Calise, F, Nicolotti, N, Vitale, A, Romagnoli, Renato, Cucchetti, A, Gruttadauria, S, Montalti, R, Caccamo, L, Vennarecci, G, Nicolini, D, Baccarani, U, Lai, Q, Manzia, Tm, Tondolo, V, Rendina, M, Scuderi, V, Perrella, A, Angelico, M, Burra, P, Fagiuoli, S, Gasbarrini, A, Cillo, U., Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Rossi, M, Tisone, G, Zamboni, F, Cuomo, O, Calise, F, Nicolotti, N, Vitale, A, Romagnoli, R, Cucchetti, A, Gruttadauria, S, Montalti, R, Caccamo, L, Vennarecci, G, Nicolini, D, Baccarani, U, Lai, Q, Manzia, T, Tondolo, V, Rendina, M, Scuderi, V, Perrella, A, Angelico, M, Burra, P, Fagiuoli, S, Gasbarrini, A, and Cillo, U

Subjects
liver transplantation, WWW.D-MELD.COM, D-MELD, LIVER TRANSPLANT
Published
2011

38. Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis

Author

Mazzaferro, V, Llovet, Jm, Miceli, R, Bhoori, S, Schiavo, M, Mariani, L, Camerini, T, Roayaie, S, Schwartz, Me, Grazi, Gl, Adam, R, Neuhaus, P, Salizzoni, M, Bruix, J, Forner, A, De Carlis, L, Cillo, U, Burroughs, Ak, Troisi, R, Rossi, M, Gerunda, Ge, Lerut, J, Belghiti, J, Boin, I, Gugenheim, J, Rochling, F, Van Hoek, B, Majno, P, Graziadei, I, Vogel, W, Lucidi, V, de Hemptinne, B, Leopardi, L, Cotsoglou, C, Iannelli, A, Staccini, A, Koenigsrainer, A, Steurer, W, Cautero, N, Risaliti, A, Lupo, L, Colledan, M, De Giorgio, M, Fagiuoli, S, Pinna, Ad, Ravaioli, M, Battiston, C, Coppa, J, Regalia, E, Romito, R, Giacomoni, A, Mangoni, J, Maggi, U, Rossi, G, Masetti, M, Montalti, R, Calise, F, Cuomo, O, Scuderi, E, Bridda, A, Vitale, A, Tisone, G, Berloco, P, Paraluppi, G, Patrono, D, Adani, Gl, Baccarani, U, Lorenzin, D, Zieniewicz, K, Ribeiro, V, Soderdahl, G, Giostra, E, Mentha, G, Morel, P, Marelli, L, Patch, D, Muiesan, P, Heaton, N, Schwartz, M, Rossaro, L, Khatri, V, Hsieh, Cb., Mazzaferro, V, Llovet, J, Miceli, R, Bhoori, S, Schiavo, M, Mariani, L, Camerini, T, Roayaie, S, Schwartz, M, Grazi, G, Adam, R, Neuhaus, P, Salizzoni, M, Bruix, J, Forner, A, De Carlis, L, Cillo, U, Burroughs, A, Troisi, R, Rossi, M, Gerunda, G, Lerut, J, Belghiti, J, Boin, I, Gugenheim, J, Rochling, F, Van Hoek, B, Majno, P, Colledan, M, Fagiuoli, S, Mazzaferro V., Llovet J.M., Miceli R., Bhoori S., Schiavo M., Mariani L., Camerini T., Roayaie S., Schwartz M.E., Grazi G.L., Adam R., Neuhaus P., Salizzoni M., Bruix J., Forner A., De Carlis L., Cillo U., Burroughs A.K., Troisi R., Rossi M., Gerunda G.E., Lerut J., Belghiti J., Boin I., Gugenheim J., Rochling F., Van Hoek B., Majno P., Graziadei I., Vogel W., Lucidi V., de Hemptinne B., Leopardi L., Cotsoglou C., Iannelli A., Staccini A., Koenigsrainer A., Steurer W., Cautero N., Risaliti A., Lupo L., Colledan M., De Giorgio M., Fagiuoli S., Pinna A.D., Ravaioli M., Battiston C., Coppa J., Regalia E., Romito R., Giacomoni A., Mangoni J., Maggi U., Rossi G., Masetti M., Montalti R., Calise F., Cuomo O., Scuderi E., Bridda A., Vitale A., Tisone G., Berloco P., Paraluppi G., Patrono D., Adani G.L., Baccarani U, Lorenzin D, Zieniewicz K, Ribeiro V, Soderdahl G., Giostra E., Mentha G., Morel P., Marelli L., Patch D., Muiesan P., Heaton N., Rossaro L., Khatri V., Hsieh C.B., Mazzaferro, Vincenzo, Llovet, Josep M, Miceli, Rosalba, Bhoori, Sherrie, Schiavo, Marcello, Mariani, Luigi, Camerini, Tiziana, Roayaie, Sasan, Schwartz, Myron E, Grazi, Gian Luca, Adam, René, Neuhaus, Peter, Salizzoni, Mauro, Bruix, Jordi, Forner, Alejandro, De Carlis, Luciano, Cillo, Umberto, Burroughs, Andrew K, Troisi, Roberto, Rossi, Massimo, Gerunda, Giorgio E, Lerut, Jan, Belghiti, Jacque, Boin, Ilka, Gugenheim, Jean, Rochling, Fedja, Van Hoek, Bart, and Majno, Pietro

Subjects
Oncology, Adult, medicine.medical_specialty, Carcinoma, Hepatocellular, Adolescent, medicine.medical_treatment, education, Liver transplantation, Milan criteria, Retrospective Studie, Liver Neoplasms/mortality/*surgery, Internal medicine, Liver Transplantation, Carcinoma, medicine, Humans, HEPATOCELLULAR CARCINOMA, Child, Aged, Retrospective Studies, mortality/surgery, ddc:617, Proportional hazards model, business.industry, Hazard ratio, Liver Neoplasms, SELECTION CRITERIA, Retrospective cohort study, Hepatocellular, Middle Aged, medicine.disease, digestive system diseases, Surgery, Carcinoma, Hepatocellular/mortality/*surgery, Transplantation, Settore MED/18 - Chirurgia Generale, Liver Neoplasm, Hepatocellular carcinoma, Adolescent, Adult, Aged, Carcinoma, mortality/surgery, Child, Humans, Liver Neoplasms, mortality/surgery, Liver Transplantation, Middle Aged, Retrospective Studies, business, Human
Abstract

Background: Patients undergoing liver transplantation for hepatocellular carcinoma within the Milan criteria (single tumour ≤5 cm in size or ≤3 tumours each ≤3 cm in size, and no macrovascular invasion) have an excellent outcome. However, survival for patients with cancers that exceed these criteria remains unpredictable and access to transplantation is a balance of maximising patients' chances of cure and organ availability. The aim of this study was to explore the survival of patients with tumours that exceed the Milan criteria, to assess whether the criteria could be less restrictive, enabling more patients to qualify as transplant candidates, and to derive a prognostic model based on objective tumour characteristics, to see whether the Milan criteria could be expanded. Methods: Data on patients who underwent transplantation for hepatocellular carcinoma despite exceeding Milan criteria at different centres were recorded via a web-based survey completed by specialists from each centre. The survival of these patients was correlated retrospectively with the size of the largest tumour nodule, number of nodules, and presence or absence of microvascular invasion detected at pathology. Contoured multivariable regression Cox models produced survival estimates by means of different combinations of the covariates. The primary aim of this study was to derive a prognostic model of overall survival based on tumour characteristics, according to the main parameters used in the Tumour Node Metastasis classification. The secondary aim was the identification of a subgroup of patients with hepatocellular carcinoma exceeding the Milan criteria, who achieved a 5-year overall survival of at least 70%-ie, similar to the outcome expected for patients who meet the Milan criteria. Findings: Over a 10-month period, between June 25, 2006, and April 3, 2007, data for 1556 patients who underwent transplantation for hepatocellular carcinoma were entered on the database by 36 centres. 1112 patients had hepatocellular carcinoma exceeding Milan criteria and 444 patients had hepatocellular carcinoma shown not to exceed Milan criteria at post-transplant pathology review. In the group of patients with hepatocellular carcinomas exceeding the criteria, the median size of the largest nodule was 40 mm (range 4-200) and the median number of nodules was four (1-20). 454 of 1112 patients (41%) had microvascular invasion and, for those transplanted outside the Milan criteria, 5-year overall survival was 53·6% (95% CI 50·1-57·0), compared with 73·3% (68·2-77·7) for those that met the criteria. Hazard ratios (HR) associated with increasing values of size and number were 1·34 (1·25-1·44) and 1·51 (1·21-1·88), respectively. The effect was linear for size, whereas for number of tumours, the effect tended to plateau above three tumours. The effect of tumour size and number on survival was mediated by recurrence (b=0·08, SE=0·12, p=0·476). The presence of microvascular invasion doubled HRs in all scenarios. The 283 patients without microvascular invasion, but who fell within the Up-to-seven criteria (hepatocellular carcinomas with seven as the sum of the size of the largest tumour [in cm] and the number of tumours) achieved a 5-year overall survival of 71·2% (64·3-77·0). Interpretation: More patients with hepatocellular carcinoma could be candidates for transplantation if the current dual (yes/no) approach to candidacy, based on the strict Milan criteria, were replaced with a more precise estimation of survival contouring individual tumour characteristics and use of the up-to-seven criteria. Funding: Specific funding was not used to do this study. © 2009 Elsevier Ltd. All rights reserved

Published
2009

39. Characteristics at presentation and outcome of hepatocellular carcinoma (HCC) in the elderly. A study of the Cancer of the Liver Italian Program (CLIP)

Author

PIGNATA S, GALLO C, DANIELE B, ELBA S, GIORGIO A, ADINOLFI LE, SIO I, IZZO F, FARINATI F, DEL NAJA C, STANZIONE M, MARONE G, CUOMO O, FELDER M, GAETA GB, DE MAIO E, DI MAIO M, SIGNORIELLO G, PERRONE F, CLIP INVESTIGATORS, CAPUANO, GAETANO, CASTIGLIONE, FABIANA, Pignata, S, Gallo, C, Daniele, B, Elba, S, Giorgio, A, Capuano, Gaetano, Adinolfi, Le, De, Sio, I, Izzo, F, Farinati, F, DEL NAJA, C, Stanzione, M, Castiglione, Fabiana, Marone, G, Cuomo, O, Felder, M, Gaeta, Gb, DE MAIO, E, DI MAIO, M, Signoriello, G, Perrone, F, and Clip, Investigators

Published
2006

40. D-MELD, a Powerful Instrument To Optimize Donor-2-Recipient Match. Differences between US and Italy

Author

Avolio, A., Halldorson, J., Lirosi, M., Agnes, S., Salizzoni, Mauro, Pinna, A., Spada, M., De Carlis, L., Colledan, M., Gerunda, G., Andorno, E., Rossi, G., Ettorre, G., Risaliti, A., Mazzaferro, V., Rossi, M., Tisone, G., Zamboni, F., Vivarelli, M., Lupo, L., Cuomo, O., Calise, F., Nicolotti, N., Vitale, A., Romagnoli, Renato, Cucchetti, A., Bonsignore, P., Mangoni, I., Pinelli, D., Montalti, R., Caccamo, L., Vennarecci, G., Nicolini, D., Regalia, E., Baccarani, U., Lai, Q., Manzia, T., Tondolo, E., Rendina, M., Perrella, A., Santaniello, W., Bottino, G., Spagnoletti, G., Mariano, G., Gasbarrini, A., Burra, P., Cillo, U., and Donor to Recipient, Italian Liver Transplant Study Group

Subjects
Liver transplantation, Liver transplantation, D-MELD, D-MELD
Published
2013

41. Behind D-MELD: the role of primary indication (HCV or HBV) as significant covariate in the outcome prediction after liver transplants

Author

Avolio, A., Agnes, S., Lirosi, M., Salizzoni, Mauro, Pinna, Ad, Gridelli, B., Decarlis, L., Colledan, M., Gerunda, G., Valente, U., Rossi, G., Ettorre, G., Risaliti, A., Mazzaferro, V., Rossi, M., Tisone, G., Zamboni, F., Lupo, L., Cuomo, O., Calise, F., Vitale, A., Nicolotti, N., Romagnoli, Renato, Cucchetti, A., Gruttadauria, S., Mangoni, I., Pinelli, D., Montalti, F., Gelli, M., Caccamo, L., Vennarecci, G., Nicolini, D., Regalia, E., Baccarani, U., Lai, Q., Manzia, T., Tondolo, E., Rendina, M., Perrella, A., Scuderi, E., Antonelli, B., de Waure, C., Angelico, M., Burra, P., Fagiuoli, S., Toniutto, P., Gasbarrini, A., and Cillo, U.

Subjects
liver transplantation, D-MELD
Published
2012

42. Graft survival is worse in HCV positive females transplanted with male donor grafts

Author

Belli, L., Romagnoli, Renato, Rossi, M., Gerunda, Ge, Pinna, Ad, Agnes, S., Spada, M., Colledan, M., Tisone, G., Decarlis, L., Baccarani, U., Mazzaferro, V., Ettorre, Gm, Cillo, U., Calise, F., Cuomo, O., Lupo, L., Ginanni Corradini, S., Zamboni, F., Marianelli, T., Risaliti, A., Patrono, Damiano, Li Petri, S., Tagliabue, F., Jme, Mangoni, Antonelli, B., Sposito, C., Gringeri, E., Rompianesi, G., Sforza, D., Cucchetti, A., Miglioresi, L., Donataccio, M., Gelli, M., Gavrila, C., Nardi, A., and Angelico, M.

Subjects
HCV infection, liver transplantation
Published
2012

47. Results of a multicenter, randomized, open-label, controlled clinical trial comparing basiliximab versus steroids in Hepatitis C positive liver transplant patients

Author

Search De Simone, P., Search De Carlis, L., Search Filipponi, F., Search Grazi, G. L., Search Cuomo, O., Search Santaniello, W., Search Magalini, S. C., Search Valente, U., Search Salizzoni, M., Search Bresadola, F., Rossi, Massimo, Search, M., Search Burra, P., Massimo, Rossi, Search, G., Search Cillo, U., Search Ferrara, R., and Corbetta, G.

Subjects
basiliximab, steroids
Published
2007

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