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1. Virologic and Immunologic Characterization of Coronavirus Disease 2019 Recrudescence After Nirmatrelvir/Ritonavir Treatment.

Author

Carlin, Aaron F, Clark, Alex E, Chaillon, Antoine, Garretson, Aaron F, Bray, William, Porrachia, Magali, Santos, AsherLev T, Rana, Tariq M, and Smith, Davey M

Subjects
*COVID-19, *GENETIC mutation, *ANTIVIRAL agents, *DRUG resistance, *DISEASE relapse, *TREATMENT effectiveness, *RITONAVIR, *DISEASE susceptibility, *RESEARCH funding, *VIROLOGY, *VIRAL antibodies
Abstract

We isolated a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) BA.2 variant from a person with coronavirus disease 2019 recrudescence after nirmatrelvir/ritonavir treatment. Antiviral sensitivity and neutralizing antibody testing were performed with both parental SARS-CoV-2 and multiple variants of concern. We found that neither nirmatrelvir resistance nor absence of neutralizing immunity was a likely cause of the recrudescence. [ABSTRACT FROM AUTHOR]

Published
2023
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