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1,363 results on '"CHENG Xiaodong"'

1. Human papillomavirus 16E6/E7 activates autophagy via Atg9B and LAMP1 in cervical cancer cells

Author

Chen Tingting, Yang Shizhou, Zhang Songfa, Xu Junfen, Lu Weiguo, Cheng Xiaodong, and Xie Xing

Subjects
Atg9B, autophagy, cervical cancer, HPV, LAMP1, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Backgrounds Although the role of high‐risk human papillomavirus (HPV) E6 and E7 in cellular malignant transformation has been elucidated， the function of both genes in cellular homeostasis is still unknown. Autophagy functions in maintenance of cellular homeostasis play a key role in the initiation and development of cancer and infectious disease. Methods Cervical cancer cell lines SiHa and CaSki were utilized in this study. Results We found that HPV 16E6/E7 (16E6/E7) downregulation inhibited autophagy, and consequently suppressed cell proliferation and promoted early apoptosis. Transcriptome sequencing demonstrated that Atg9B and LAMP1 were downregulated in 16E6/E7 knockdown cells. Gene function experiments revealed that 16E6/E7 downregulation depressed Atg9B and LAMP1, and Atg9B and LAMP1 overexpression compensated, at least partially, autophagy blockage induced by 16E6/E7 knockdown. Immunoprecipitation assay showed that 16E7 interacted with Atg9B and dual‐luciferase reporter system revealed that 16E6 most likely regulated −1750 to −2000 nt in Atg9B and −1800 to −2000 nt in LAMP1 promoter region. Conclusions Our findings verified that 16E6/E7 activated autophagy via accelerating autophagosome formation and degradation, and Atg9B and LAMP1 were involved in the process of 16E6/E7 modulating autophagy, suggesting that targeting autophagy may be a potential approach in cervical cancer therapeutics.

Published
2019
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3. Research on the regulation of Three Gorges Reservoir in response to saltwater intrusion in the Yangtze River Estuary

Author

Cheng Xiaodong and Xu Tao

Subjects
Environmental sciences, GE1-350
Abstract

With the changes of economic society and human activities to the natural environment, the impact of saltwater intrusion becomes more frequent and the degree of harm becomes more serious. The Yangtze River Estuary is a densely populated and economically developed area in China, but in terms of water resources utilization, the Yangtze River Estuary is often suffering from saltwater intrustion in dry season. As the backbone of the cascade reservoirs in the Yangtze River Basin, the scientific operation of the Three Gorges Reservoir plays an active role in reducing the saltwater intrusion in the Yangtze River Estuary. Therefore, based on the analysis of the characteristics of Yangtze River Estuary, this paper sums up the variations of saltwater intrusion and discusses the main dynamic factors of saltwater intrusion. In addition, it explores the internal relationship between the upstream water volume and the saltwater intrusion. It takes the allocation of the fresh water resources by the water resources regulation of the Three Gorges Reservoir as a main discussing point. In the end, this paper focuses on the countermeasures and effect of emergency water replenishment on the saltwater intrusion in the Yangtze River Estuary.

Published
2022
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29. A ribosomal gene panel predicting a novel synthetic lethality in non-BRCAness tumors

Author

Zhang, Chao, Guo, Qiang, Chen, Lifeng, Wu, Zheming, Yan, Xiao-Jian, Zou, Chengyang, Zhang, Qiuxue, Tan, Jiahong, Fang, Tian, Rao, Qunxian, Li, Yang, Shen, Shizhen, Deng, Min, Wang, Liewei, Gao, Huanyao, Yu, Jia, Li, Hu, Zhang, Cheng, Nowsheen, Somaira, Kloeber, Jake, Zhao, Fei, Yin, Ping, Teng, Chunbo, Lin, Zhongqiu, Song, Kun, Yao, Shuzhong, Yao, Liangqing, Wu, Lingying, Zhang, Yong, Cheng, Xiaodong, Gao, Qinglei, Yuan, Jian, Lou, Zhenkun, and Zhang, Jin-San

Published
2023
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35. Prevalence and risk profile of cervical human papillomavirus infection in Zhejiang Province, southeast China: a population-based study

Author

Lü Weiguo, Ye Feng, Chen Xiaojing, Cheng Xiaodong, Ye Jing, and Xie Xing

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Benign or malignant lesions caused by Human papillomavirus (HPV) produce considerable health burden worldwide. Since limited cross-protection would be offered between HPV types, heterogeneity in HPV type-specific distribution should be taken into account when predicting the effect of current prophylactic vaccines and forming the basic for the second-generation vaccines targeted to specific regions. Here, we investigated the prevalence of cervical HPV infection, as well as predictors concerned, in Zhejiang Province, southeast China. Results Totally 4987 cervical samples from five randomly chosen counties in Zhejiang Province were detected. The overall HPV prevalence was 13.3%. Established high-risk (HR) HPV prevalence was 10.2%. HPV-52 was the most prevalent type (3.1%), followed by HPV-16 (2.5%), -58 (2.1%), -68 (1.0%) and -81 (0.9%). HPV-16 or -18 were present in 3.1% of the detected samples, while 174 specimens (3.5%) were positive for any of HPV-6, -11, -16 and -18. The prevalence of HPV vaccine types was consistently low across age groups. Bimodal age distribution in HR-HPV, including established HR and probably HR-HPV, was observed, with a clear second peak in perimenopausal women. Multivariate unconditional logistic regression models revealed that partner's lifetime number of partners was the only common independent predictor of overall, established HR, established low-risk, single-type and multiple-type HPV infection in current study. Conclusions We have observed low prevalence of HPV vaccine types and relatively high prevalence of HPV-52 and -58 in our population. Our findings support universal "catch-up" vaccination of sexual experienced young women in Zhejiang Province, as well as enhance the hypothesis that the second-generation HPV prophylactic vaccines including HPV-52 and -58 may offer higher protection for women in China and other Asian areas. Furthermore, our data support close surveillance of perimenopausal women with HR-HPV infection.

Published
2010
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39. Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervical cancer: a randomized, non-inferiority, multicenter trial

Author

Weng, Danhui, Xiong, Huihua, Zhu, Changkun, Wan, Xiaoyun, Chen, Yaxia, Wang, Xinyu, Zhang, Youzhong, Jiang, Jie, Zhang, Xi, Gao, Qinglei, Chen, Gang, Xing, Hui, Wang, Changyu, Li, Kezhen, Chen, Yaheng, Mao, Yuyan, Hu, Dongxiao, Pan, Zimin, Chen, Qingqin, Cui, Baoxia, Song, Kun, Yi, Cunjian, Peng, Guangcai, Han, Xiaobing, An, Ruifang, Fan, Liangsheng, Wang, Wei, Xiong, Tingchuan, Chen, Yile, Tang, Zhenzi, Li, Lin, Yang, Xingsheng, Cheng, Xiaodong, Lu, Weiguo, Wang, Hui, Kong, Beihua, Xie, Xing, and Ma, Ding

Published
2023
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