496 results on '"Byrnes, J."'
Search Results
2. A New View of Shear Wavespeed and the Lithosphere‐Asthenosphere Boundary in the Southwestern United States.
- Author
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Golos, E. M., Brunsvik, B., Eilon, Z., Fischer, K. M., Byrnes, J., and Gaherty, J.
- Subjects
SEISMIC wave velocity ,SURFACE of the earth ,PLATE tectonics ,RAYLEIGH waves ,PHASE velocity - Abstract
The Southwestern United States experiences active deformation, seismicity, and magmatism, remarkable in an intraplate setting. The Basin and Range and Colorado Plateau (CP) are inferred to differ in lithospheric thickness, but modeling geophysical properties of the lithosphere, in particular the depth of the Lithosphere‐Asthenosphere Boundary (LAB), across the entirety of the region, has proved challenging. Here, we introduce a new model of 1‐D depth profiles in shear wavespeed, determined through a probabilistic joint inversion of information from Sp receiver functions and Rayleigh wave phase velocity. From these profiles we quantify the locations and Vs contrast of wavespeed gradients that represent boundaries such as the Moho, the LAB, and intralithospheric discontinuities. We infer a lithosphere that is thinner and lower in Vs in the Basin and Range. In the CP and farther north, the LAB is more gradual, deeper, and intermittently observed. We also observe Mid‐Lithospheric Discontinuities (MLDs) near the boundaries between the CP, Wyoming Craton, and Northern Basin and Range, as well as within the Craton. When both an MLD and LAB are observed, the Vs gradient associated with the LAB is narrower than expected. Finally, we image Positive Velocity Gradients beneath areas of thinner lithosphere, which are consistent with recent global observations that have been attributed to the base of a partially molten zone below the lithosphere. Overall, the picture of the lithosphere‐asthenosphere system that emerges is one of considerable structural complexity with a strong dependency on tectonic regime and geological history. Plain Language Summary: We examine the properties of, and processes that shape, the lithosphere—the rigid outermost layer of the Earth, which participates in plate tectonics. Our focus is the southwestern United States where in fact the lithosphere does not behave like a simple, homogeneous, plate. Instead, in the Basin and Range Province, widespread deformation, frequent earthquakes, and recent volcanic activity are observed, all of which are rare for a location removed from plate boundaries. In the neighboring Colorado Plateau and the regions north and west of it, the lithosphere behaves more rigidly but volcanism is also observed. To understand how the lithosphere and mantle below vary, we produce a model of seismic wavespeed using data from surface waves, which travel along the Earth's surface, and converted body waves, which interact with interior boundaries such as the bottom of the lithosphere. This model enables us to find the depths of major boundaries and understand how the speed of seismic waves changes across them. We consistently observe decreases in seismic wavespeed that we associate with the bottom of the lithosphere or structures within the lithosphere. We also note wavespeed increases below the lithosphere that might indicate partial melting of rocks deep within the Earth. Key Points: We perform a joint inversion for Vs in the upper mantle of the Southwestern U.S., using data from body wave scattering and surface wavesThe lithosphere varies regionally: it is flat and thin in the Basin and Range, thicker in the Colorado Plateau, and complex in cratonic regionsMid‐Lithospheric Discontinuities are observed in cratonic regions, associated with sharp Vs gradients at the base of the lithosphere [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
3. Thermoelectric performance of thermally aged nanostructured bulk materials—a case study of lead chalcogenides
- Author
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Byrnes, J., Mitchell, D.R.G., and Aminorroaya Yamini, S.
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- 2020
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4. International HTA Experience with Targeted Therapy Approvals for Lung Cancer
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Maraiki, Fatma, Byrnes, J., Tuffaha, H., and Hinder, M.
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- 2019
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5. Australian cardiac rehabilitation exercise parameter characteristics and perceptions of high-intensity interval training: a cross-sectional survey
- Author
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Hannan AL, Hing W, Climstein M, Coombes JS, Furness J, Jayasinghe R, and Byrnes J
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Coronary artery disease ,exercise ,interval training ,cardiovascular disease ,Sports medicine ,RC1200-1245 - Abstract
Amanda L Hannan,1 Wayne Hing,1 Mike Climstein,2 Jeff S Coombes,3 James Furness,1 Rohan Jayasinghe,4–6 Joshua Byrnes7 1Faculty of Health Sciences & Medicine, Bond University, Gold Coast, QLD, Australia; 2Exercise Health and Performance Faculty Research Group, Faculty of Health Sciences, The University of Sydney, Sydney, NSW, Australia; 3School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, QLD, Australia; 4Cardiology Department, Gold Coast University Hospital, Gold Coast, QLD, Australia; 5Griffith University, Gold Coast, QLD, Australia; 6Macquarie University, Sydney, NSW, Australia; 7Centre for Applied Health Economics, School of Medicine, Griffith University, Logan, QLD, Australia Purpose: This study explored current demographics, characteristics, costs, evaluation methods, and outcome measures used in Australian cardiac rehabilitation (CR) programs. It also determined the actual usage and perceptions of high-intensity interval training (HIIT).Methods: A cross-sectional observational web-based survey was distributed to 328 Australian CR programs nationally.Results: A total of 261 programs completed the survey (79.6% response rate). Most Australian CR programs were located in a hospital setting (76%), offered exercise sessions once a week (52%) for 6–8 weeks (49%) at moderate intensity (54%) for 46–60 min (62%), and serviced 101–500 clients per annum (38%). HIIT was reported in only 1% of programs, and 27% of respondents believed that it was safe while 42% of respondents were unsure. Lack of staff (25%), monitoring resources (20%), and staff knowledge (18%) were the most commonly reported barriers to the implementation of HIIT. Overall, Australian CR coordinators are unsure of the cost of exercise sessions.Conclusion: There is variability in CR delivery across Australia. Only half of programs reassess outcome measures postintervention, and cost of exercise sessions is unknown. Although HIIT is recommended in international CR guidelines, it is essentially not being used in Australia and clinicians are unsure as to the safety of HIIT. Lack of resources and staff knowledge were perceived as the biggest barriers to HIIT implementation, and there are inconsistent perceptions of prescreening and monitoring requirements. This study highlights the need to educate health professionals about the benefits and safety of HIIT to improve its usage and patient outcomes. Keywords: coronary artery disease, exercise, interval training, cardiovascular disease
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- 2018
6. High-intensity interval training versus moderate-intensity continuous training within cardiac rehabilitation: a systematic review and meta-analysis
- Author
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Hannan AL, Hing W, Simas V, Climstein M, Coombes JS, Jayasinghe R, Byrnes J, and Furness J
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coronary artery disease ,cardiac rehabilitation ,interval training ,exercise ,Sports medicine ,RC1200-1245 - Abstract
Amanda L Hannan,1 Wayne Hing,1 Vini Simas,1 Mike Climstein,2,3 Jeff S Coombes,4 Rohan Jayasinghe,5–7 Joshua Byrnes,8 James Furness1 1Faculty of Health Sciences & Medicine, Bond University, Gold Coast, QLD, Australia; 2Exercise Health and Performance Faculty Research Group, Faculty of Health Sciences, The University of Sydney, Sydney, NSW, Australia; 3Water Based Research Unit, Bond University, Gold Coast, QLD, Australia; 4School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, QLD, Australia; 5Cardiology Department, Gold Coast University Hospital, Gold Coast, QLD, Australia; 6Griffith University, Gold Coast, QLD, Australia; 7Macquarie University, Sydney, NSW, Australia; 8Centre for Applied Health Economics, School of Medicine, Griffith University, Logan, QLD, Australia Background: Aerobic capacity has been shown to be inversely proportionate to cardiovascular mortality and morbidity and there is growing evidence that high-intensity interval training (HIIT) appears to be more effective than moderate-intensity continuous training (MICT) in improving cardiorespiratory fitness within the cardiac population. Previously published systematic reviews in cardiovascular disease have neither investigated the effect that the number of weeks of intervention has on cardiorespiratory fitness changes, nor have adverse events been collated. Objective: We aimed to undertake a systematic review and meta-analysis of randomized controlled trials (RCTs) within the cardiac population that investigated cardiorespiratory fitness changes resulting from HIIT versus MICT and to collate adverse events. Methods: A critical narrative synthesis and meta-analysis was conducted after systematically searching relevant databases up to July 2017. We searched for RCTs that compared cardiorespiratory fitness changes resulting from HIIT versus MICT interventions within the cardiac population. Results: Seventeen studies, involving 953 participants (465 for HIIT and 488 for MICT) were included in the analysis. HIIT was significantly superior to MICT in improving cardiorespiratory fitness overall (SMD 0.34 mL/kg/min; 95% confidence interval [CI; 0.2–0.48]; p6-week duration. Programs of 7–12 weeks’ duration resulted in the largest improvements in cardiorespiratory fitness for patients with coronary artery disease. HIIT appears to be as safe as MICT for CR participants. Keywords: coronary artery disease, cardiac rehabilitation, interval training, exercise, intensity, physical therapy, cardiovascular disease
- Published
- 2018
7. Lateral Variations in Teleseismic Attenuation of the Conterminous U.S. and New Insights Derived From Its Relationship to Mantle Seismic Velocity.
- Author
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Bezada, M. J., Byrnes, J. S., Zhu, Z., and Lee, H.
- Subjects
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SEISMIC wave velocity , *SURFACE waves (Seismic waves) , *SHEAR waves , *IMAGING systems in seismology , *SEISMIC waves , *LITHOSPHERE , *GRAIN size - Abstract
Much of our knowledge of the North American lithosphere comes from imaging seismic velocities. Additional constraints on the subsurface can be gained by studying seismic attenuation, which has different sensitivity to physical properties. We produce a model of lateral variations in attenuation across the conterminous U.S. by analyzing data recorded by the EarthScope Transportable Array. We divide the study area into 12 overlapping tiles and differential attenuation is measured in each tile independently; and twice for four of the tiles. Measurements are combined into a smooth map using a set of linear inversions. Comparing results for adjacent tiles and for repeated tiles shows that the imaged features are robust. The final map shows generally higher attenuation west of the Rocky Mountain Front than east of it, with significant small length scale variations superimposed on that broad pattern. In general, there is a strong anticorrelation between differential attenuation and shear wave velocities at depths of 80–250 km. However, a given change in velocity may correspond to a large or small change in attenuation, depending on the area; suggesting that different physical mechanisms are operating. In the western and south‐central U.S., as well as the Appalachians, velocity variations are large compared to attenuation changes, while the opposite is true in the north‐central and southeastern U.S. Calculations with the Very Broadband Rheology calculator show that these results are consistent with the main source of heterogeneity being temperature and melt fraction in the former regions and grain size variability in the latter ones. Plain Language Summary: Seismic waves in the mantle propagate at lower speeds when temperatures are higher, rocks have higher water content, and small amounts of melt are present. These conditions also affect how much energy the wave loses as it passes through, which we call seismic attenuation. In this study we produce a map of seismic attenuation for the conterminous United States. We find that, in most places, where seismic velocities are low, attenuation is high, and vice versa. This is what we expect. Interestingly, the size of the change in attenuation that corresponds to a given change in velocity varies by region. In places with thicker lithosphere and without recent tectonic activity attenuation anomalies are large compared to velocity anomalies, the opposite is true in places with thin lithosphere and recent tectonic activity. Considering the results of lab experiments on velocity and attenuation, this suggests that in the regions with thick lithosphere and without recent tectonic activity the main cause of the anomalies is changes in the size of the mineral grains in the mantle, whereas in the regions with thin lithosphere and recent tectonic activity the main cause of the anomalies is changes in temperature and the amount of melt. Key Points: Teleseismic P attenuation is largely anti‐correlated with upper mantle seismic velocitySignificant lateral variations in attenuation are observed in the tectonically quiescent regionsThe ratio of attenuation to velocity anomaly amplitudes may be indicative of mantle conditions [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
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8. Vaginal salpingo-oophorectomy: Tips and tricks: 6
- Author
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Schmitt, J., Byrnes, J. N., Hokenstad, E. D., and Gebhart, J.
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- 2017
- Full Text
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9. (152) - Explantation of Durable Ventricular Assist Device for Myocardial Functional Recovery in Children: A Report from The Action Registry
- Author
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Langanecha, B., Jeewa, A., Adachi, I., Mavroudis, C., Shezad, M., Butts, R., Auerbach, S.R., VanderPluym, C., Zinn, M., Kindel, S., Sutcliffe, D., Khan, S., Byrnes, J., Lorts, A., Castleberry, C., Mettler, B., Absi, M., Rosenthal, D., Joong, A., Law, S., Nandi, D., May, L., Parent, J., Conway, J., Tunuguntla, H., Aljohani, O., Bleiweis, M., and Hope, K.
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- 2024
- Full Text
- View/download PDF
10. Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data
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Romagnoni, A., Jegou, S., Van Steen, K., Wainrib, G., Hugot, J. -P., Peyrin-Biroulet, L., Chamaillard, M., Colombel, J. -F., Cottone, M., D'Amato, M., D'Inca, R., Halfvarson, J., Henderson, P., Karban, A., Kennedy, N. A., Khan, M. A., Lemann, M., Levine, A., Massey, D., Milla, M., S. M. E., Ng, Oikonomou, I., Peeters, H., Proctor, D. D., Rahier, J. -F., Rutgeerts, P., Seibold, F., Stronati, L., Taylor, K. M., Torkvist, L., Ublick, K., Van Limbergen, J., Van Gossum, A., Vatn, M. H., Zhang, H., Zhang, W., Andrews, J. M., Bampton, P. A., Barclay, M., Florin, T. H., Gearry, R., Krishnaprasad, K., Lawrance, I. C., Mahy, G., Montgomery, G. W., Radford-Smith, G., Roberts, R. L., Simms, L. A., Hanigan, K., Croft, A., Amininijad, L., Cleynen, I., Dewit, O., Franchimont, D., Georges, M., Laukens, D., Theatre, E., Vermeire, S., Aumais, G., Baidoo, L., Barrie, A. M., Beck, K., Bernard, E. -J., Binion, D. G., Bitton, A., Brant, S. R., Cho, J. H., Cohen, A., Croitoru, K., Daly, M. J., Datta, L. W., Deslandres, C., Duerr, R. H., Dutridge, D., Ferguson, J., Fultz, J., Goyette, P., Greenberg, G. R., Haritunians, T., Jobin, G., Katz, S., Lahaie, R. G., Mcgovern, D. P., Nelson, L., S. M., Ng, Ning, K., Pare, P., Regueiro, M. D., Rioux, J. D., Ruggiero, E., Schumm, L. P., Schwartz, M., Scott, R., Sharma, Y., Silverberg, M. S., Spears, D., Steinhart, A. H., Stempak, J. M., Swoger, J. M., Tsagarelis, C., Zhang, C., Zhao, H., Aerts, J., Ahmad, T., Arbury, H., Attwood, A., Auton, A., Ball, S. G., Balmforth, A. J., Barnes, C., Barrett, J. C., Barroso, I., Barton, A., Bennett, A. J., Bhaskar, S., Blaszczyk, K., Bowes, J., Brand, O. J., Braund, P. S., Bredin, F., Breen, G., Brown, M. J., Bruce, I. N., Bull, J., Burren, O. S., Burton, J., Byrnes, J., Caesar, S., Cardin, N., Clee, C. M., Coffey, A. J., MC Connell, J., Conrad, D. F., Cooper, J. D., Dominiczak, A. F., Downes, K., Drummond, H. E., Dudakia, D., Dunham, A., Ebbs, B., Eccles, D., Edkins, S., Edwards, C., Elliot, A., Emery, P., Evans, D. M., Evans, G., Eyre, S., Farmer, A., Ferrier, I. N., Flynn, E., Forbes, A., Forty, L., Franklyn, J. A., Frayling, T. M., Freathy, R. M., Giannoulatou, E., Gibbs, P., Gilbert, P., Gordon-Smith, K., Gray, E., Green, E., Groves, C. J., Grozeva, D., Gwilliam, R., Hall, A., Hammond, N., Hardy, M., Harrison, P., Hassanali, N., Hebaishi, H., Hines, S., Hinks, A., Hitman, G. A., Hocking, L., Holmes, C., Howard, E., Howard, P., Howson, J. M. M., Hughes, D., Hunt, S., Isaacs, J. D., Jain, M., Jewell, D. P., Johnson, T., Jolley, J. D., Jones, I. R., Jones, L. A., Kirov, G., Langford, C. F., Lango-Allen, H., Lathrop, G. M., Lee, J., Lee, K. L., Lees, C., Lewis, K., Lindgren, C. M., Maisuria-Armer, M., Maller, J., Mansfield, J., Marchini, J. L., Martin, P., Massey, D. C., Mcardle, W. L., Mcguffin, P., Mclay, K. E., Mcvean, G., Mentzer, A., Mimmack, M. L., Morgan, A. E., Morris, A. P., Mowat, C., Munroe, P. B., Myers, S., Newman, W., Nimmo, E. R., O'Donovan, M. C., Onipinla, A., Ovington, N. R., Owen, M. J., Palin, K., Palotie, A., Parnell, K., Pearson, R., Pernet, D., Perry, J. R., Phillips, A., Plagnol, V., Prescott, N. J., Prokopenko, I., Quail, M. A., Rafelt, S., Rayner, N. W., Reid, D. M., Renwick, A., Ring, S. M., Robertson, N., Robson, S., Russell, E., Clair, D. S., Sambrook, J. G., Sanderson, J. D., Sawcer, S. J., Schuilenburg, H., Scott, C. E., Seal, S., Shaw-Hawkins, S., Shields, B. M., Simmonds, M. J., Smyth, D. J., Somaskantharajah, E., Spanova, K., Steer, S., Stephens, J., Stevens, H. E., Stirrups, K., Stone, M. A., Strachan, D. P., Su, Z., Symmons, D. P. M., Thompson, J. R., Thomson, W., Tobin, M. D., Travers, M. E., Turnbull, C., Vukcevic, D., Wain, L. V., Walker, M., Walker, N. M., Wallace, C., Warren-Perry, M., Watkins, N. A., Webster, J., Weedon, M. N., Wilson, A. G., Woodburn, M., Wordsworth, B. P., Yau, C., Young, A. H., Zeggini, E., Brown, M. A., Burton, P. R., Caulfield, M. J., Compston, A., Farrall, M., Gough, S. C. L., Hall, A. S., Hattersley, A. T., Hill, A. V. S., Mathew, C. G., Pembrey, M., Satsangi, J., Stratton, M. R., Worthington, J., Hurles, M. E., Duncanson, A., Ouwehand, W. H., Parkes, M., Rahman, N., Todd, J. A., Samani, N. J., Kwiatkowski, D. P., Mccarthy, M. I., Craddock, N., Deloukas, P., Donnelly, P., Blackwell, J. M., Bramon, E., Casas, J. P., Corvin, A., Jankowski, J., Markus, H. S., Palmer, C. N., Plomin, R., Rautanen, A., Trembath, R. C., Viswanathan, A. C., Wood, N. W., Spencer, C. C. A., Band, G., Bellenguez, C., Freeman, C., Hellenthal, G., Pirinen, M., Strange, A., Blackburn, H., Bumpstead, S. J., Dronov, S., Gillman, M., Jayakumar, A., Mccann, O. T., Liddle, J., Potter, S. C., Ravindrarajah, R., Ricketts, M., Waller, M., Weston, P., Widaa, S., Whittaker, P., Romagnoni, A., Jegou, S., Van Steen, K., Wainrib, G., Hugot, J. -P., Peyrin-Biroulet, L., Chamaillard, M., Colombel, J. -F., Cottone, M., D'Amato, M., D'Inca, R., Halfvarson, J., Henderson, P., Karban, A., Kennedy, N. A., Khan, M. A., Lemann, M., Levine, A., Massey, D., Milla, M., Ng, S. M. E., Oikonomou, I., Peeters, H., Proctor, D. D., Rahier, J. -F., Rutgeerts, P., Seibold, F., Stronati, L., Taylor, K. M., Torkvist, L., Ublick, K., Van Limbergen, J., Van Gossum, A., Vatn, M. H., Zhang, H., Zhang, W., Andrews, J. M., Bampton, P. A., Barclay, M., Florin, T. H., Gearry, R., Krishnaprasad, K., Lawrance, I. C., Mahy, G., Montgomery, G. W., Radford-Smith, G., Roberts, R. L., Simms, L. A., Hanigan, K., Croft, A., Amininijad, L., Cleynen, I., Dewit, O., Franchimont, D., Georges, M., Laukens, D., Theatre, E., Vermeire, S., Aumais, G., Baidoo, L., Barrie, A. M., Beck, K., Bernard, E. -J., Binion, D. G., Bitton, A., Brant, S. R., Cho, J. H., Cohen, A., Croitoru, K., Daly, M. J., Datta, L. W., Deslandres, C., Duerr, R. H., Dutridge, D., Ferguson, J., Fultz, J., Goyette, P., Greenberg, G. R., Haritunians, T., Jobin, G., Katz, S., Lahaie, R. G., Mcgovern, D. P., Nelson, L., Ng, S. M., Ning, K., Pare, P., Regueiro, M. D., Rioux, J. D., Ruggiero, E., Schumm, L. P., Schwartz, M., Scott, R., Sharma, Y., Silverberg, M. S., Spears, D., Steinhart, A. H., Stempak, J. M., Swoger, J. M., Tsagarelis, C., Zhang, C., Zhao, H., Aerts, J., Ahmad, T., Arbury, H., Attwood, A., Auton, A., Ball, S. G., Balmforth, A. J., Barnes, C., Barrett, J. C., Barroso, I., Barton, A., Bennett, A. J., Bhaskar, S., Blaszczyk, K., Bowes, J., Brand, O. J., Braund, P. S., Bredin, F., Breen, G., Brown, M. J., Bruce, I. N., Bull, J., Burren, O. S., Burton, J., Byrnes, J., Caesar, S., Cardin, N., Clee, C. M., Coffey, A. J., MC Connell, J., Conrad, D. F., Cooper, J. D., Dominiczak, A. F., Downes, K., Drummond, H. E., Dudakia, D., Dunham, A., Ebbs, B., Eccles, D., Edkins, S., Edwards, C., Elliot, A., Emery, P., Evans, D. M., Evans, G., Eyre, S., Farmer, A., Ferrier, I. N., Flynn, E., Forbes, A., Forty, L., Franklyn, J. A., Frayling, T. M., Freathy, R. M., Giannoulatou, E., Gibbs, P., Gilbert, P., Gordon-Smith, K., Gray, E., Green, E., Groves, C. J., Grozeva, D., Gwilliam, R., Hall, A., Hammond, N., Hardy, M., Harrison, P., Hassanali, N., Hebaishi, H., Hines, S., Hinks, A., Hitman, G. A., Hocking, L., Holmes, C., Howard, E., Howard, P., Howson, J. M. M., Hughes, D., Hunt, S., Isaacs, J. D., Jain, M., Jewell, D. P., Johnson, T., Jolley, J. D., Jones, I. R., Jones, L. A., Kirov, G., Langford, C. F., Lango-Allen, H., Lathrop, G. M., Lee, J., Lee, K. L., Lees, C., Lewis, K., Lindgren, C. M., Maisuria-Armer, M., Maller, J., Mansfield, J., Marchini, J. L., Martin, P., Massey, D. C., Mcardle, W. L., Mcguffin, P., Mclay, K. E., Mcvean, G., Mentzer, A., Mimmack, M. L., Morgan, A. E., Morris, A. P., Mowat, C., Munroe, P. B., Myers, S., Newman, W., Nimmo, E. R., O'Donovan, M. C., Onipinla, A., Ovington, N. R., Owen, M. J., Palin, K., Palotie, A., Parnell, K., Pearson, R., Pernet, D., Perry, J. R., Phillips, A., Plagnol, V., Prescott, N. J., Prokopenko, I., Quail, M. A., Rafelt, S., Rayner, N. W., Reid, D. M., Renwick, A., Ring, S. M., Robertson, N., Robson, S., Russell, E., Clair, D. S., Sambrook, J. G., Sanderson, J. D., Sawcer, S. J., Schuilenburg, H., Scott, C. E., Seal, S., Shaw-Hawkins, S., Shields, B. M., Simmonds, M. J., Smyth, D. J., Somaskantharajah, E., Spanova, K., Steer, S., Stephens, J., Stevens, H. E., Stirrups, K., Stone, M. A., Strachan, D. P., Su, Z., Symmons, D. P. M., Thompson, J. R., Thomson, W., Tobin, M. D., Travers, M. E., Turnbull, C., Vukcevic, D., Wain, L. V., Walker, M., Walker, N. M., Wallace, C., Warren-Perry, M., Watkins, N. A., Webster, J., Weedon, M. N., Wilson, A. G., Woodburn, M., Wordsworth, B. P., Yau, C., Young, A. H., Zeggini, E., Brown, M. A., Burton, P. R., Caulfield, M. J., Compston, A., Farrall, M., Gough, S. C. L., Hall, A. S., Hattersley, A. T., Hill, A. V. S., Mathew, C. G., Pembrey, M., Satsangi, J., Stratton, M. R., Worthington, J., Hurles, M. E., Duncanson, A., Ouwehand, W. H., Parkes, M., Rahman, N., Todd, J. A., Samani, N. J., Kwiatkowski, D. P., Mccarthy, M. I., Craddock, N., Deloukas, P., Donnelly, P., Blackwell, J. M., Bramon, E., Casas, J. P., Corvin, A., Jankowski, J., Markus, H. S., Palmer, C. N., Plomin, R., Rautanen, A., Trembath, R. C., Viswanathan, A. C., Wood, N. W., Spencer, C. C. A., Band, G., Bellenguez, C., Freeman, C., Hellenthal, G., Pirinen, M., Strange, A., Blackburn, H., Bumpstead, S. J., Dronov, S., Gillman, M., Jayakumar, A., Mccann, O. T., Liddle, J., Potter, S. C., Ravindrarajah, R., Ricketts, M., Waller, M., Weston, P., Widaa, S., Whittaker, P., Daly, Mark J. [0000-0002-0949-8752], Apollo - University of Cambridge Repository, Hugot, Jean-Pierre [0000-0002-8446-6056], UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - (MGD) Service de gastro-entérologie, Romagnoni, A, Jegou, S, VAN STEEN, Kristel, Wainrib, G, Hugot, JP, Peyrin-Biroulet, L, Chamaillard, M, Colombel, JF, Cottone, M, D'Amato, M, D'Inca, R, Halfvarson, J, Henderson, P, Karban, A, Kennedy, NA, Khan, MA, Lemann, M, Levine, A, Massey, D, Milla, M, Ng, SME, Oikonomou, I, Peeters, H, Proctor, DD, Rahier, JF, Rutgeerts, P, Seibold, F, Stronati, L, Taylor, KM, Torkvist, L, Ublick, K, Van Limbergen, J, Van Gossum, A, Vatn, MH, Zhang, H, Zhang, W, Andrews, JM, Bampton, PA, Barclay, M, Florin, TH, Gearry, R, Krishnaprasad, K, Lawrance, IC, Mahy, G, Montgomery, GW, Radford-Smith, G, Roberts, RL, Simms, LA, Hanigan, K, Croft, A, Amininijad, L, Cleynen, I, Dewit, O, Franchimont, D, Georges, M, Laukens, D, Theatre, E, Vermeire, S, Aumais, G, Baidoo, L, Barrie, AM, Beck, K, Bernard, EJ, Binion, DG, Bitton, A, Brant, SR, Cho, JH, Cohen, A, Croitoru, K, Daly, MJ, Datta, LW, Deslandres, C, Duerr, RH, Dutridge, D, Ferguson, J, Fultz, J, Goyette, P, Greenberg, GR, Haritunians, T, Jobin, G, Katz, S, Lahaie, RG, McGovern, DP, Nelson, L, Ng, SM, Ning, K, Pare, P, Regueiro, MD, Rioux, JD, Ruggiero, E, Schumm, LP, Schwartz, M, Scott, R, Sharma, Y, Silverberg, MS, Spears, D, Steinhart, AH, Stempak, JM, Swoger, JM, Tsagarelis, C, Zhang, C, Zhao, HY, AERTS, Jan, Ahmad, T, Arbury, H, Attwood, A, Auton, A, Ball, SG, Balmforth, AJ, Barnes, C, Barrett, JC, Barroso, I, Barton, A, Bennett, AJ, Bhaskar, S, Blaszczyk, K, Bowes, J, Brand, OJ, Braund, PS, Bredin, F, Breen, G, Brown, MJ, Bruce, IN, Bull, J, Burren, OS, Burton, J, Byrnes, J, Caesar, S, Cardin, N, Clee, CM, Coffey, AJ, Mc Connell, J, Conrad, DF, Cooper, JD, Dominiczak, AF, Downes, K, Drummond, HE, Dudakia, D, Dunham, A, Ebbs, B, Eccles, D, Edkins, S, Edwards, C, Elliot, A, Emery, P, Evans, DM, Evans, G, Eyre, S, Farmer, A, Ferrier, IN, Flynn, E, Forbes, A, Forty, L, Franklyn, JA, Frayling, TM, Freathy, RM, Giannoulatou, E, Gibbs, P, Gilbert, P, Gordon-Smith, K, Gray, E, Green, E, Groves, CJ, Grozeva, D, Gwilliam, R, Hall, A, Hammond, N, Hardy, M, Harrison, P, Hassanali, N, Hebaishi, H, Hines, S, Hinks, A, Hitman, GA, Hocking, L, Holmes, C, Howard, E, Howard, P, Howson, JMM, Hughes, D, Hunt, S, Isaacs, JD, Jain, M, Jewell, DP, Johnson, T, Jolley, JD, Jones, IR, Jones, LA, Kirov, G, Langford, CF, Lango-Allen, H, Lathrop, GM, Lee, J, Lee, KL, Lees, C, Lewis, K, Lindgren, CM, Maisuria-Armer, M, Maller, J, Mansfield, J, Marchini, JL, Martin, P, Massey, DCO, McArdle, WL, McGuffin, P, McLay, KE, McVean, G, Mentzer, A, Mimmack, ML, Morgan, AE, Morris, AP, Mowat, C, Munroe, PB, Myers, S, Newman, W, Nimmo, ER, O'Donovan, MC, Onipinla, A, Ovington, NR, Owen, MJ, Palin, K, Palotie, A, Parnell, K, Pearson, R, Pernet, D, Perry, JRB, Phillips, A, Plagnol, V, Prescott, NJ, Prokopenko, I, Quail, MA, Rafelt, S, Rayner, NW, Reid, DM, Renwick, A, Ring, SM, Robertson, N, Robson, S, Russell, E, St Clair, D, Sambrook, JG, Sanderson, JD, Sawcer, SJ, Schuilenburg, H, Scott, CE, Seal, S, Shaw-Hawkins, S, Shields, BM, Simmonds, MJ, Smyth, DJ, Somaskantharajah, E, Spanova, K, Steer, S, Stephens, J, Stevens, HE, Stirrups, K, Stone, MA, Strachan, DP, Su, Z, Symmons, DPM, Thompson, JR, Thomson, W, Tobin, MD, Travers, ME, Turnbull, C, Vukcevic, D, Wain, LV, Walker, M, Walker, NM, Wallace, C, Warren-Perry, M, Watkins, NA, Webster, J, Weedon, MN, Wilson, AG, Woodburn, M, Wordsworth, BP, Yau, C, Young, AH, Zeggini, E, Brown, MA, Burton, PR, Caulfield, MJ, Compston, A, Farrall, M, Gough, SCL, Hall, AS, Hattersley, AT, Hill, AVS, Mathew, CG, Pembrey, M, Satsangi, J, Stratton, MR, Worthington, J, Hurles, ME, Duncanson, A, Ouwehand, WH, Parkes, M, Rahman, N, Todd, JA, Samani, NJ, Kwiatkowski, DP, McCarthy, MI, Craddock, N, Deloukas, P, Donnelly, P, Blackwell, JM, Bramon, E, Casas, JP, Corvin, A, Jankowski, J, Markus, HS, Palmer, CNA, Plomin, R, Rautanen, A, Trembath, RC, Viswanathan, AC, Wood, NW, Spencer, CCA, Band, G, Bellenguez, C, Freeman, C, Hellenthal, G, Pirinen, M, Strange, A, Blackburn, H, Bumpstead, SJ, Dronov, S, Gillman, M, Jayakumar, A, McCann, OT, Liddle, J, Potter, SC, Ravindrarajah, R, Ricketts, M, Waller, M, Weston, P, Widaa, S, Whittaker, P, and Kwiatkowski, D
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Male ,692/4020/1503/257/1402 ,Genotype ,Genotyping Techniques ,LOCI ,45/43 ,lcsh:Medicine ,Polymorphism, Single Nucleotide ,Crohn's disease, genetics, genome wide association ,Article ,Deep Learning ,Crohn Disease ,INDEL Mutation ,Genetics research ,Humans ,genetics ,Genetic Predisposition to Disease ,129 ,lcsh:Science ,Alleles ,Science & Technology ,genome wide association ,RISK PREDICTION ,45 ,Models, Genetic ,lcsh:R ,Decision Trees ,692/308/2056 ,ASSOCIATION ,Multidisciplinary Sciences ,Crohn's disease ,Logistic Models ,Nonlinear Dynamics ,ROC Curve ,Area Under Curve ,Science & Technology - Other Topics ,lcsh:Q ,Female ,Neural Networks, Computer ,INFLAMMATORY-BOWEL-DISEASE ,Genome-Wide Association Study - Abstract
Crohn Disease (CD) is a complex genetic disorder for which more than 140 genes have been identified using genome wide association studies (GWAS). However, the genetic architecture of the trait remains largely unknown. The recent development of machine learning (ML) approaches incited us to apply them to classify healthy and diseased people according to their genomic information. The Immunochip dataset containing 18,227 CD patients and 34,050 healthy controls enrolled and genotyped by the international Inflammatory Bowel Disease genetic consortium (IIBDGC) has been re-analyzed using a set of ML methods: penalized logistic regression (LR), gradient boosted trees (GBT) and artificial neural networks (NN). The main score used to compare the methods was the Area Under the ROC Curve (AUC) statistics. The impact of quality control (QC), imputing and coding methods on LR results showed that QC methods and imputation of missing genotypes may artificially increase the scores. At the opposite, neither the patient/control ratio nor marker preselection or coding strategies significantly affected the results. LR methods, including Lasso, Ridge and ElasticNet provided similar results with a maximum AUC of 0.80. GBT methods like XGBoost, LightGBM and CatBoost, together with dense NN with one or more hidden layers, provided similar AUC values, suggesting limited epistatic effects in the genetic architecture of the trait. ML methods detected near all the genetic variants previously identified by GWAS among the best predictors plus additional predictors with lower effects. The robustness and complementarity of the different methods are also studied. Compared to LR, non-linear models such as GBT or NN may provide robust complementary approaches to identify and classify genetic markers. Tis work was supported by Fondation pour la Recherche Médical (ref DEI20151234405) and Investissements d’Avenir programme ANR-11-IDEX-0005-02, Sorbonne Paris Cite, Laboratoire d’excellence INFLAMEX. Te authors thank the students that participated to the wisdom of the crowd exercise.
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- 2019
11. Patient-led, technology-assisted malnutrition risk screening in hospital
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Roberts, S., Hopper, Z., Bromiley, L., Kelly, J., Byrnes, J., Ball, L., Collins, P., and Marshall, A.
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- 2023
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12. Fibrinogen, red blood cells, and factor XIII in venous thrombosis
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WALTON, B. L., BYRNES, J. R., and WOLBERG, A. S.
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- 2015
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13. Development of a preference-based heart disease-specific health state classification system using MacNew heart disease-related quality of life instrument
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Kularatna, S., Rowen, D., Mukuria, C., McPhail, S., Chen, G., Mulhern, B., Whitty, J.A., Byrnes, J., Scuffham, P., Atherton, J., Höfer, S., and Parsonage, W.
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1117 Public Health and Health Services, 1701 Psychology ,Health Policy & Services - Abstract
Purpose:\ud The MacNew Heart Disease Health Related Quality of Life Instrument (MacNew) is a validated, clinically sensitive, 27-item disease-specific questionnaire. This study aimed to develop a new heart-disease-specific classification system for the MacNew amenable for use in health-state valuation.\ud \ud \ud Methods:\ud Patients with heart-disease attending outpatient clinics and inpatient wards in Brisbane, Australia, completed MacNew.The development of the new disease-specific classification system included three stages. First, a principal component analysis (PCA) established dimensionality. Second, Rasch analysis was used to select items for each dimension. Third, Rasch analysis was used to explore response-level reduction. In addition, clinician and patient judgement informed item selection.\ud \ud \ud Results:\ud Participants included 685 patients (acute coronary 6%, stable coronary 41%, chronic heart failure 20%). The PCA identified 4 dimensions (restriction, emotion, perception of others, and symptoms). The restriction dimension was divided into physical and social dimensions. One item was selected from each to be included in the classification system. Three items from the emotional dimension and two symptom items were also selected. The final classification system had seven dimensions with four severity levels in each: physical restriction; excluded from doing things with other people; worn out or low in energy; frustrated, impatient or angry; unsure and lacking in self-confidence; shortness of breath; and chest pain.\ud \ud \ud Conclusion:\ud This study generated a brief heart disease-specific classification system, consisting of seven dimensions with four severity levels in each. The classification system is amenable to valuation to enable the generation of utility value sets to be developed for use in economic evaluation.
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- 2021
14. The L 4 Norm of a Polynomial with Coefficients ± 1
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Newman, Donald J. and Byrnes, J. S.
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- 1990
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15. Case Study: Management of an Infected Mid Dermal Friction Burn
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Byrnes, J
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- 2006
16. Complete Multipliers
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Byrnes, J. S.
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- 1972
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17. Uniqueness Theorems for Convolution-Type Equations
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Byrnes, J. S. and Newman, D. J.
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- 1969
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18. Completeness Preserving Multipliers
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Byrnes, J. S. and Newman, D. J.
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- 1969
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19. Autologous transplantation for relapsed non-Hodgkin's lymphoma using intravenous busulfan and cyclophosphamide as conditioning regimen: a single center experience
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Escalón, M P, Stefanovic, A, Venkatraman, A, Pereira, D, Santos, E S, Goodman, M, Byrnes, J J, and Fernandez, H F
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- 2009
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20. Valuation study for a preference-based quality of life measure for dental caries (Dental Caries Utility Index - DCUI) among Australian adolescents - study protocol
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Hettiarachchi R, Kularatna S, Byrnes J, Mulhern B, Chen G, and Scuffham PA
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1103 Clinical Sciences, 1117 Public Health and Health Services, 1199 Other Medical and Health Sciences - Abstract
IntroductionA new health state classification system has been developed for dental caries - Dental Caries Utility Index (DCUI) to facilitate the assessment of oral health interventions in the cost-utility analysis (CUA). This paper reports the protocol for a valuation study, which aims to generate a preference-based algorithm for the classification system for the DCUI.Methods and analysisDiscrete choice experiments (DCEs) will be conducted to value health states generated by the DCUI classification system and preferences for these health states will be modelled to develop a utility algorithm. DCEs produce utility values on a latent scale and these values will be anchored into the full health-dead scale to calculate the quality-adjusted life years in CUA. There is no previous evidence for the most suitable anchoring method for dental caries health state valuation. Hence, we will first conduct pilot studies with two anchoring approaches; DCE including duration attribute and DCE anchoring to worst heath state in Visual Analogue Scale. Based on the pilot studies, the most suitable anchoring method among two approaches will be used in the main valuation survey, which will be conducted as an online survey among a representative sample of 2000 adults from the Australian general population. Participants will be asked to complete a set of DCE choice tasks along with anchoring tasks, basic social-demographic questions, DCUI, a generic preference-based measure and oral health quality of life instrument.Ethics and disseminationEthical approval for this study was obtained from the Human Research Ethics Committee, Griffith University (reference number HREC/2019/550). The generated algorithm will facilitate the use of the new dental caries preference-based measure in economic evaluations of oral health interventions. The results will be disseminated through journal articles and professional conferences.
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- 2020
21. Health Technology Assessment in Australia: The Pharmaceutical Benefits Advisory Committee and Medical Services Advisory Committee
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Kim, H, Byrnes, J, Goodall, S, and committee, ISPORACE
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Technology Assessment, Biomedical ,Pharmaceutical Preparations ,Cost-Benefit Analysis ,parasitic diseases ,education ,Advisory Committees ,Australia ,Humans ,1115 Pharmacology and Pharmaceutical Sciences, 1117 Public Health and Health Services, 1402 Applied Economics - Abstract
Health technology assessment (HTA) was introduced in Australia for the reimbursement of pharmaceuticals in 1992 and in the following years for procedures, diagnostic tests, and devices. The Australian health system is largely funded by the government. The Pharmaceutical Benefits Scheme is a national list of prescription pharmaceuticals for which the patient pays a small copayment. HTA submissions to the Pharmaceutical Benefits Scheme are assessed by the Pharmaceutical Benefits Advisory Committee. The Medical Benefits Scheme provides ambulatory medical services and HTA submissions are assessed by the Medical Services Advisory Committee. This article describes the processes of reimbursement in Australia as well as the special case of codependent technologies (eg, diagnostic test and a therapeutic drug) where a combined Medical Services Advisory Committee and Pharmaceutical Benefits Advisory Committee application is required. There are many future challenges for HTA in Australia, with growing pressure to provide early access to promising treatments and high cost personalized medicines looming on the horizon. However, Australia is well placed to deal with these issues as the early adoption of HTA and coexistence between industry, academia and the payer has proven to be a fertile environment for developing capacity to undertake and evaluate HTA.
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- 2020
22. EE468 The Cost-Effectiveness and Budget Impact of Itopride Hydrochloride for the Treatment of Functional Dyspepsia in Vietnam
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Kim, K., Kim, H., Byrnes, J., Bian, A.R., and Nguyen Thi Thu, C.
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- 2023
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23. Does facility type and location impact upon patient experiences in emergency departments? Secondary analysis of a state-wide, cross-sectional survey
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Bull, C, Crilly, J, Chaboyer, W, Spain, D, Mulhern, B, Fitzgerald, G, Scuffham, P, and Byrnes, J
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1103 Clinical Sciences, 1117 Public Health and Health Services ,Emergency & Critical Care Medicine - Abstract
OBJECTIVE:To identify the extent to which patient experiences in the ED differ depending on facility type (based on bed numbers, services available and annual separations), and location (level of remoteness). METHODS:Data from a 2015 state-wide (Queensland, Australia) public ED patient experience survey were linked to sociodemographic and presentation-related characteristics data. Survey items were individually scored (from 0 to 100), and averaged across 13 pre-determined patient experience topic areas. Descriptive statistics were used to report on patient sociodemographic and presentation-related characteristics. One-way analysis of variance tests were used to identify associations between patient-reported experience scores, facility types and location. RESULTS:A total of 10 553 patients over the age of 16 years completed the survey. All patients reported scores above 75 for 7 of the 13 patient experience topic areas (0 = lowest score, 100 = highest score). Patients from very remote and outer regional EDs reported the highest scores for the topic Environment and facilities, and remote facility patients reported the highest scores for the topic Leaving the ED - Delays. The same two topic areas were scored most highly by patients from smaller facilities in comparison to principal referral hospital EDs. CONCLUSIONS:Patients attending smaller and more rurally located EDs reported more positive experiences than those attending larger, metropolitan EDs on two of the 13 topic areas. However, these differences were marginal. Future research should aim to determine what constitutes clinically meaningful differences between groups when comparing patient-reported experience scores, and understand the characteristics of small and rural EDs that may be associated with better patient experiences.
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- 2019
24. Elevated prothrombin promotes venous, but not arterial, thrombosis in mice: implications for investigating vascular bed-specific mechanisms in humans: OC 49.3
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Aleman, M, Walton, B L, Byrnes, J R, Wang, J-G, Heisler, M J, Machlus, K R, Cooley, B C, and Wolberg, A S
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- 2013
25. Smooth PONS
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Byrnes, J. S., Moran, W., and Saffari, B.
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- 2000
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26. Sex ratio of multiple sclerosis and clinical phenotype
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Ramagopalan, S. V., Byrnes, J. K., Orton, S.-M., Dyment, D. A., Guimond, C., Yee, I. M., Ebers, G. C., and Sadovnick, A. D.
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- 2010
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27. EE342 Pancreatic Exocrine Insufficiency in Patients Who Have Undergone Surgery Due to Pancreatic Cancer: A Chinese Cost-Utility Analysis
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Kim, H, Byrnes, J, Jiang, K, Liao, Z, Kim, K, Fragkogianni, D, and Roberts, K
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- 2022
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28. The cost of hospitalisation for youth self-harm: differences across age groups, sex, Indigenous and non-Indigenous populations
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Kinchin I, Russell AMT, Byrnes J, McCalman J, Doran CM, and Hunter E
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Psychiatry ,Adult ,Male ,Adolescent ,Episode of Care ,Australia ,Health Care Costs ,Length of Stay ,Hospitalization ,Oceanic Ancestry Group ,Suicide ,Young Adult ,Age Distribution ,Cost of Illness ,Humans ,Female ,Sex Distribution ,1103 Clinical Sciences, 1701 Psychology, 1702 Cognitive Sciences ,Self-Injurious Behavior - Abstract
Objective To report the comparative rates, average length of stay and cost per episode of hospital management for self-harm in three age cohorts: 15–19 years, 20–24 years and 25–29 years; by sex and indigeneity. Design, setting, participants A secondary data analysis of the Australian Institute of Health and Welfare (AIHW) dataset between 1st January 2014 and 31st December 2014 inclusive. Main outcome measures Cost per episode of hospitalised self-harm and rates by age group, sex and Indigenous status. Results The rate of hospitalised self-harm among Australian youth was 254.0 per 100,000 population. This rate resulted in an annual cost to the healthcare system of AU$55 million or an average cost per episode of $4649 (95% CI $4488:$4810). Hospitalised self-harm was 21 times higher than the rate of suicide (11,820 episodes of hospitalised self-harm/564 suicides). Indigenous youth had on average a 1.4 times higher rate of hospitalised self-harm and 2.2 times higher rate of suicide than non-Indigenous counterparts. When controlling for age and sex, the average cost per episode was significantly lower for Indigenous youth compared to non-Indigenous youth, estimated marginal means $4538 and $4954, respectively (p
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- 2019
29. The WIND magnetic field investigation
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Lepping, R. P., Acũna, M. H., Burlaga, L. F., Farrell, W. M., Slavin, J. A., Schatten, K. H., Mariani, F., Ness, N. F., Neubauer, F. M., Whang, Y. C., Byrnes, J. B., Kennon, R. S., Panetta, P. V., Scheifele, J., and Worley, E. M.
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- 1995
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30. The Massivity of the Square
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Byrnes, J. S.
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- 1971
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31. A Complete Set Which is not a Basis
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Byrnes, J. S.
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- 1972
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32. Body Wave Tomography of the Cascadia Subduction Zone and Juan de Fuca Plate System: Identifying Challenges and Solutions for Shore‐Crossing Data.
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Bodmer, M., Toomey, D. R., VanderBeek, B., Hooft, E. E., and Byrnes, J. S.
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HETEROGENEITY ,OCEAN ,SUBDUCTION ,VELOCITY ,CASCADIA subduction zone - Abstract
Recent seismic results from the Cascadia Initiative indicate that heterogeneity in the oceanic asthenosphere affects subduction dynamics. Accurate characterization of the oceanic upper mantle is thus necessary to fully understand subduction processes, including the behavioral segmentation of the megathrust. A key challenge is integrating onshore and offshore datasets, which span large variations in near‐surface features that teleseismic body wave tomography is ill‐posed to resolve. Here, we perform a series of P and S forward modeling predictions to better understand the relative contribution of elevation, crustal thickness, offshore sedimentation, and near‐surface velocity structure to teleseismic delay times. Crustal thickness and elevation variations dominate the signal, contributing ∼1 s of delay time difference for P‐waves (roughly double for S). We test several inversion strategies to account for near‐surface features, identifying potential artifacts and causes of imaging errors. Undamped station statics are found to absorb mantle structures and introduce low‐velocity artifacts beneath the forearc. Our preferred inversion strategy utilizes a three‐dimensional starting model (including elevation) of the upper 50 km and heavily damped station statics, which we find leads to better resolution of mantle structure, particularly at asthenospheric depths. These insights guide inversions of observed delay times from the Cascadia subduction zone and Juan de Fuca plate system. We present a new onshore‐offshore S model and an updated P model. Major features are common to both models, including localized subslab low‐velocity anomalies, along‐strike variations in slab structure, and offshore heterogeneity, while regional differences may reflect changes in Vp/Vs. Key Points: Isotropic onshore‐offshore teleseismic body wave tomography of the Cascadia subduction zone; Updated P‐ and new S‐wave modelsForward modeling quantifies the effects of crustal thickness, elevation, sediments, and velocity variations on the shore‐crossing datasetWe explore the impacts of inversion strategy choices, identify imaging artifacts, and outline a preferred methodology [ABSTRACT FROM AUTHOR]
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- 2020
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33. Catalog of solar wind events identified from observations by ISTP spacecraft
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Peredo, M, Berdichevsky, D, Byrnes, J, Lepping, R. P, Ogilvie, K, Lazarus, A. J, Paularena, K. I, and Steinberg, J. T
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Solar Physics - Abstract
The ISTP Science Planning and Operations Facility (SPOF), in collaboration with ISTP investigators, is developing a catalog of solar wind events and features. The catalog is primarily based on plasma and magnetic field observations from the WIND and IMP-8 spacecraft. Interplanetary events that may trigger magnetospheric activity are included as well as features of interest for using the solar wind as a plasma laboratory. Catalog coverage begins on September 8, 1992, the start of ISTP science data collection. The catalog is based on Key Parameter data sets (preliminary summary data at approximately 1 min time resolution produced quickly for survey purposes) and as such has limited citability in formal scientific work. Its primary intent is to serve as a reference for identifying candidate periods for further study, such as may be the focus of coordinated data analysis efforts during ISTP and/or IACG Science Campaigns. To facilitate access by members of the ISTP and wider space physics communities, the catalog will be available on the World Wide Web. The contents of the catalog will be described, and samples of catalog information will be presented.
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- 1995
34. WIND measurements of proton and alpha particle flow and number density
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Steinberg, J. T, Lazarus, A. J, Ogilvie, J. T, Lepping, R, Byrnes, J, Chornay, D, Keller, J, Torbert, R. B, Bodet, D, and Needell, G. J
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Solar Physics - Abstract
We propose to review measurements of the solar wind proton and alpha particle flow velocities and densities made since launch with the WIND SWE instrument. The SWE Faraday cup ion sensors are designed to be able to determine accurately flow vector directions, and thus can be used to detect proton-alpha particle differential flow. Instances of differential flow, and the solar wind features with which they are associated will be discussed. Additionally, the variability of the percentage of alpha particles as a fraction of the total solar wind ion density will be presented.
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- 1995
35. PRO2 Economic Evaluation of Reproductive Carrier Screening for Recessive Genetic Conditions: A Systematic Review
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Wang, T., Bahrampour, M., Byrnes, J., Scuffham, P., and Downes, M.
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- 2020
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36. PNS69 Measuring and Valuing Patient Experience
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Byrnes, J.
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- 2020
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37. PND27 Valuing Health States Using Discrete Choice Experiment: Case of Cerebral Palsy
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Bahrampour, M., Norman, R., Byrnes, J., Downes, M., and Scuffham, P.
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- 2020
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38. 750 Secondary Prevention of Coronary Heart Disease and the Role of Predicted Risks
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Huynh, Q., Nghiem, S., Byrnes, J., Scuffham, P., and Marwick, T.
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- 2020
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39. Cost-effectiveness of volumetric alcohol taxation in Australia
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Byrnes, J. M., Cobiac, L. J., Doran, C. M., Vos, T., and Anthony Shakeshaft
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health care economics and organizations - Abstract
OBJECTIVE: To estimate the potential health benefits and cost savings of an alcohol tax rate that applies equally to all alcoholic beverages based on their alcohol content (volumetric tax) and to compare the cost savings with the cost of implementation. DESIGN AND SETTING: Mathematical modelling of three scenarios of volumetric alcohol taxation for the population of Australia: (i) no change in deadweight loss, (ii) no change in tax revenue, and (iii) all alcoholic beverages taxed at the same rate as spirits. MAIN OUTCOME MEASURES: Estimated change in alcohol consumption, tax revenue and health benefit. RESULTS: The estimated cost of changing to a volumetric tax rate is $18 million. A volumetric tax that is deadweight loss-neutral would increase the cost of beer and wine and reduce the cost of spirits, resulting in an estimated annual increase in taxation revenue of $492 million and a 2.77% reduction in annual consumption of pure alcohol. The estimated net health gain would be 21 000 disability-adjusted life-years (DALYs), with potential cost offsets of $110 million per annum. A tax revenue-neutral scenario would result in an 0.05% decrease in consumption, and a tax on all alcohol at a spirits rate would reduce consumption by 23.85% and increase revenue by $3094 million [corrected]. All volumetric tax scenarios would provide greater health benefits and cost savings to the health sector than the existing taxation system, based on current understandings of alcohol-related health effects. CONCLUSIONS: An equalized volumetric tax that would reduce beer and wine consumption while increasing the consumption of spirits would need to be approached with caution. Further research is required to examine whether alcohol-related health effects vary by type of alcoholic beverage independent of the amount of alcohol consumed to provide a strong evidence platform for alcohol taxation policies.
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- 2016
40. On the robustness of attenuation measurements on teleseismic P waves: insights from micro-array analysis of the 2017 North Korean nuclear test.
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Bezada, M J, Byrnes, J, and Eilon, Z
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SEISMIC waves , *NUCLEAR weapons testing , *MOLE fraction , *TIME series analysis , *SIGNAL processing , *MEASUREMENT , *TESTING - Abstract
Despite their importance as a fundamental constraint on Earth properties, regional-scale measurements of body-wave seismic attenuation are scarce. This is partially a result of the difficulty in producing robust estimates of attenuation. In this paper, we focus on measuring differential attenuation on records of teleseismic P waves. We examine a unique data set of five records of the North Korean nuclear test of 2017 measured at five broad-band seismic stations deployed within a few metres of each other but using different installation procedures. Given their extreme proximity, we expect zero differential intrinsic attenuation between the different records. However, we find that different attenuation measurement methods and implementation parameters in fact produce significant apparent differential attenuation (Δ t *). Frequency-domain methods yield a wide range of Δ t * estimates between stations, depending on measurement bandwidth and nuances of signal processing. This measurement instability increases for longer time windows. Time domain methods are largely insensitive to the frequency band being considered but are sensitive to the time window that is chosen. We determine that signal-generated noise can affect measurements in both the frequency and time domain. In some cases, the range of results amounts to a significant fraction of the range of differential attenuation across the conterminous United States as determined by a recent study. We suggest some approaches to manage the inherent instability in these measurements and recommend best practices to confidently estimate body wave attenuation. [ABSTRACT FROM AUTHOR]
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- 2019
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41. Andrew Thompson, 1773-1810. 1. To the arrival of Macquarie; 2. Macquarie and the Thompson legacy
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Byrnes, J. V.
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- 1962
42. PRM41 - Development of an Online Time Trade off Methods for Health State Valuation
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Kularatna, S, Byrnes, J, Chen, G, and Scuffham, P
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- 2018
- Full Text
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43. Elevated Prothrombin Promotes Venous, but Not Arterial, Thrombosis in Mice
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Machlus, K. R., Aleman, M. M., Byrnes, J. R., Wolberg, A. S., Walton, B. L., Wang, J.-G., Heisler, M. J., and Cooley, B. C.
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hemic and lymphatic diseases ,circulatory and respiratory physiology - Abstract
Individuals with elevated prothrombin, including those with the prothrombin G20210A mutation, have increased risk of venous thrombosis. Although these individuals do not have increased circulating prothrombotic biomarkers, their plasma demonstrates increased tissue factor-dependent thrombin generation in vitro. The objectives of this study were to determine the pathologic role of elevated prothrombin in venous and arterial thrombosis in vivo, and distinguish thrombogenic mechanisms in these vessels.
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- 2013
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44. Assessing phase discrimination via the segmentation of an elemental energy dispersive X-ray spectroscopy map: a case study of Bi2Te3 and Bi2Te2S.
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Byrnes, J. B., Gazder, A. A., and Aminorroaya Yamini, S.
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- 2018
- Full Text
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45. Bayesian refinement of association signals for 14 loci in 3 common diseases
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Maller, JB, McVean, G, Byrnes, J, Vukcevic, D, Palin, K, Su, Z, Howson, JMM, Auton, A, Myers, S, Morris, A, Pirinen, M, Brown, MA, Burton, PR, Caulfield, MJ, Compston, A, Farrall, M, Hall, AS, Hattersley, AT, Hill, AVS, Mathew, CG, Pembrey, M, Satsangi, J, Stratton, MR, Worthington, J, Craddock, N, Hurles, M, Ouwehand, W, Parkes, M, Rahman, N, Duncanson, A, Todd, JA, Kwiatkowski, DP, Samani, NJ, Gough, SCL, McCarthy, MI, Deloukas, P, and Donnelly, P
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endocrine system diseases ,Posterior probability ,Alpha-Ketoglutarate-Dependent Dioxygenase FTO ,Single-nucleotide polymorphism ,Genome-wide association study ,Coronary Artery Disease ,Biology ,FTO gene ,Polymorphism, Single Nucleotide ,Article ,Bayes' theorem ,Genetics ,Humans ,CTLA-4 Antigen ,Genetic Predisposition to Disease ,Genetic association ,Cyclin-Dependent Kinase Inhibitor p15 ,Homeodomain Proteins ,tRNA Methyltransferases ,Genes, p16 ,Proteins ,nutritional and metabolic diseases ,Bayes Theorem ,Cyclin-Dependent Kinase 5 ,Graves Disease ,TRNA Methyltransferases ,Diabetes Mellitus, Type 2 ,Genetic Loci ,TCF7L2 ,Transcription Factor 7-Like 2 Protein ,Genome-Wide Association Study ,Transcription Factors - Abstract
To further investigate susceptibility loci identified by genome-wide association studies, we genotyped 5,500 SNPs across 14 associated regions in 8,000 samples from a control group and 3 diseases: type 2 diabetes (T2D), coronary artery disease (CAD) and Graves' disease. We defined, using Bayes theorem, credible sets of SNPs that were 95% likely, based on posterior probability, to contain the causal disease-associated SNPs. In 3 of the 14 regions, TCF7L2 (T2D), CTLA4 (Graves' disease) and CDKN2A-CDKN2B (T2D), much of the posterior probability rested on a single SNP, and, in 4 other regions (CDKN2A-CDKN2B (CAD) and CDKAL1, FTO and HHEX (T2D)), the 95% sets were small, thereby excluding most SNPs as potentially causal. Very few SNPs in our credible sets had annotated functions, illustrating the limitations in understanding the mechanisms underlying susceptibility to common diseases. Our results also show the value of more detailed mapping to target sequences for functional studies. © 2012 Nature America, Inc. All rights reserved.
- Published
- 2012
46. Ethylene Injury to Cut Flowers in Cold Storage Rooms
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Lumsden, D. Victor, Wright, R. C., Whiteman, T. M., and Byrnes, J. Wise
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- 1940
47. A Lower Jackson Bound on (- ∞, ∞)
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Byrnes, J. S. and Newman, D. J.
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- 1970
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48. PCN252 - International HTA Experience With Targeted Therapy Approvals For Lung Cancer
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Maraiki, F, Byrnes, J, Tuffaha, H, and Hider, M
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- 2017
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49. Predator diversity strengthens trophic cascades in kelp forests by modifying herbivore behaviour
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Byrnes, J, Stachowicz, J J, Hultgren, K M, Hughes, A R, Olyarnik, S V, and Thornber, C S
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trophic cascade ,multiple predator effects ,trait-mediated indirect interactions ,behaviourally modified interaction ,biodiversity ecosystem function ,kelp forest ,predator diversity ,human activities - Abstract
Although human-mediated extinctions disproportionately affect higher trophic levels, the ecosystem consequences of declining diversity are best known for plants and herbivores. We combined field surveys and experimental manipulations to examine the consequences of changing predator diversity for trophic cascades in kelp forests. In field surveys we found that predator diversity was negatively correlated with herbivore abundance and positively correlated with kelp abundance. To assess whether this relationship was causal, we manipulated predator richness in kelp mesocosms, and found that decreasing predator richness increased herbivore grazing, leading to a decrease in the biomass of the giant kelp Macrocystis. The presence of different predators caused different herbivores to alter their behaviour by reducing grazing, such that total grazing was lowest at highest predator diversity. Our results suggest that declining predator diversity can have cascading effects on community structure by reducing the abundance of key habitat-providing species.
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- 2006
50. PHP81 - EQ-5D Utility Value Sets for Sri Lanka: A Case For Economic Evaluations in South Asia
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Kularatna, S, Byrnes, J, Chen, G, and Scuffham, P
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- 2016
- Full Text
- View/download PDF
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