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Three major attacks have previously been used on invasive carcinoma of the urinary bladder - surgical extirpation, irradiation therapy and chemotherapy. Of the chemotherapeutic agents, only systemic 5-fluorouracil has proved to possess merit. In a study of therapy with a judicious combination of these three therapeutic approaches in 32 cases, it appeared that tumor response was better and there were fewer major complications than with therapy by any one method. The report is preliminary, as the period of observation in not yet long enough.