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Pulmonary arterial hypertension has evolved from a fatal disease with few treatment options to a chronic condition with improved survival. This improvement is possible through development of effective therapies as well as the expansion of risk stratification scores to assist clinical decision making. Despite improved disease control, quality of life, and overall prognosis, many challenges remain. The treatment itself is burdensome, with significant impact on quality of life. Many patients with pulmonary arterial hypertension still present with advanced, often end‐stage disease. Increased use of mechanical circulatory support and catheter‐based interventions have expanded use of extracorporeal life support and right ventricle assist devices. For these reasons as well as the long‐term relationships pulmonary hypertension physicians have with patients and their families, navigating the course of the illness in a considered, proactive way is essential. Understanding individual goals and revisiting them as they change over time requires comfort with the conversation itself. There are many barriers and challenges to having effective, compassionate conversations in the clinical setting with time constraints being the most often cited. Compressed visits are necessarily focused on the clinical aspects, therapy and medication adherence and tolerance. Clinicians are sometimes wary of diminishing hope in the face of ongoing treatment. Having sufficient experience and comfort with these discussions can be empowering. In this paper, we discuss the challenges involved and propose a framework to assist in incorporating these discussions into clinical care.

The concept of returning to sport for a professional athlete is still under debate for the professional athlete in today’s sports environment. It is critical for the professional athlete to be able to return to sport at a highly competitive level but also to return in a safe and timely measure. With no “gold standard” of sport testing, it is difficult to determine what the right progression or testing regimen should be. The Return to Sport Clearance Continuum does not look at one moment in time, but looks throughout the continuum of healing to determine readiness for sport. The purpose of this article is to explore the concept of RTS being part of an evolving continuum rather than the traditional notion that RTS is a single decision made at a discrete point in time. The principles of progressive but regular testing procedures including qualitative and quantitative movement are presented to help the professional athlete return to sport at their maximal performance level. Level of Evidence: V, expert opinion.

We described insulin glargine (originator) and insulin glargine-yfgn (biosimilar) treatment patterns, assessed effectiveness and safety outcomes, and identified reasons for switching back to the originator product from the biosimilar. This retrospective study included 328,463 Veterans 18 years of age and older who received one or more outpatient prescriptions for insulin glargine and/or insulin glargine-yfgn between 1 June 2021 and 31 December 2022. Patients were assigned to subgroups based on the initial prescription during the study period, prevalent versus incident use for originator insulin glargine, and prior versus no prior use of the originator before the biosimilar (i.e., prevalent originator non-switcher (n = 189,734), originator switch to biosimilar (n = 81,010), incident originator non-switcher (n = 49,401), and incident biosimilar (n = 8318)). There were no differences in the outcome of mean HbA1c (7.9% for all subgroups). There were also no differences in the unadjusted rates of hospitalization and/or emergency room visits for hyper- and hypoglycemia between the prevalent originator non-switcher and originator switched to biosimilar subgroups (p = 0.09 and 0.38, respectively) or the incident originator non-switcher and incident biosimilar subgroups (p = 0.054 and 0.61, respectively). Finally, none of the HbA1c or hyperglycemia outcomes adjusted for baseline characteristics were statistically different. Adjusted analyses for rates of hospitalization and/or emergency room visits for hypoglycemia could not be performed due to the low number of events. Overall, patients who received insulin glargine-yfgn had similar effectiveness and safety outcomes as patients who received the originator. [ABSTRACT FROM AUTHOR]

We investigated the influence of postglacial population expansion on the genetic structure of reproductively isolated populations that come into secondary contact and produce hybrid zones. We tested migratory behaviour to explain geographical patterns of genetic diversity and phylogeographical structure in migratory and sedentary populations of hummingbirds in the Chihuahuan Desert. We assessed genetic structure, demographic expansion and introgression in Calothorax hummingbirds using mitochondrial DNA (mtDNA) and nuclear microsatellites and used ecological niche modelling to predict where migratory and sedentary populations resided during Pleistocene climate events. Bayesian analysis yielded three clusters. However, only two clusters matched mtDNA haplogroups, one parental in the south (C. pulcher) and a cluster with two admixed taxa (sedentary and migratory C. lucifer) that cannot be attributed to any pure parental population. Demographic expansion, gene flow and admixture in the C. lucifer range, postglacial northern expansion predicted by ecological niche modelling, and approximate Bayesian computation strongly supported a scenario of divergence with gene flow: a Pleistocene basal split separating C. pulcher ; and the other two clades are derived from a second split (migratory and sedentary C. lucifer). Population genetic admixture was higher in localities with lower inferred stability of habitat suitability. The genetic differentiation of Calothorax may be explained by the combined effects of the following factors: (1) gene flow and recent postglacial northern expansion from southern sedentary populations; (2) increased genetic admixture with lower stability of habitat suitability; and (3) the evolution of long-distance seasonal migration during glacial–interglacial cycles, suggesting a role for diversification through the divergence of migratory subpopulations that become sedentary. [ABSTRACT FROM AUTHOR]

The article presents a study focusing on courtship displays and sonations of a hybrid male Broad-taled x Black-chinned Hummingbird. It showed that the hybrid performed shuttle and dive displays similar to the displays of parental species and his wing and tail morphology were intermediate between those of the parental species. It concludes that snmall changes in morphology can lead to comparatively large changes in sound production.

The article presents information on the Convention for the Conservation of Anadromous Stocks in the North Pacific Ocean signed by the U.S. in 1992. This international agreement prohibits fishing for salmon in the North Pacific Ocean. It is informed that salmon are an anadromous species. It is observed that the fishing industry has played an important role in the economies of states such as Alaska, Idaho, and Oregon in the U.S. The U.S. government had always advocated for a ban on high seas salmon fishing. It is observed that the actual enforcement provisions of this treaty need some improvement.

Introduction: Outcomes in colorectal cancer treatment are historically worse in Black people and residents of rural areas. Purported reasons include factors such as systemic racism, poverty, lack of access to care, and social determinants of health. We sought to determine whether outcomes worsened when race and rural residence intersected. Methods: The National Cancer Database was queried for individuals with stage II–III colorectal cancer (2004-2018). To examine the intersectionality of race/rurality on outcomes, race (Black/White) and rurality (based on county) were combined into a single variable. Main outcome of interest was 5-year survival. Cox hazard regression analysis was performed to determine variables independently associating with survival. Control variables included age at diagnosis, sex, race, Charlson-Deyo score, insurance status, stage, and facility type. Results: Of 463 948 patients, 5717 were Black-Rural, 50 742 were Black-Urban, 72 241 were White-Rural, and 33 5271 were White-Urban. Five-year mortality rate was 31.6%. Univariate Kaplan-Meier survival analysis demonstrated race-rurality was associated with overall survival (P <.001), with White-Urban having the greatest mean survival length (47.9 months) and Black-Rural with the lowest (46.7 months). Multivariable analysis found that Black-Rural (1.26, 95% confidence interval [1.20-1.32]), Black-Urban (1.16, [1.16-1.18]), and White-Rural (HR: 1.05; (1.04-1.07) had increased mortality when compared to White-Urban individuals (P <.001). Conclusion: Although White-Rural individuals fared worse than White-Urban, Black individuals fared worst of all, with the poorest outcomes observed in Black individuals in rural areas. This suggests that both Black race and rurality negatively affect survival, and act synergistically to further worsen outcomes. [ABSTRACT FROM AUTHOR]

Background: Laparoendoscopic transhiatal esophagectomy (THE) provides advantages over traditional THE by not only avoiding laparotomy but by also allowing more precise esophageal mobilization. Occasionally, the length of the gastric conduit is insufficient to allow delivery into the neck after laparoscopic mobilization and requires laparotomy to complete the procedure. We hypothesize that the need for laparotomy will correlate with the measurement of mediastinal height (distance from thoracic vertebrae T1-T12) on chest CT.Methods: Medical records of all patients who underwent attempted laparoendoscopic-assisted THE at a tertiary referral center between March 1, 2003 and January 31, 2019 were reviewed. Patients' mediastinal height was measured using computed tomography (CT) imaging of the chest by investigators and analyzed for correlation between mediastinal height and successful completion of a totally laparoendoscopic procedure.Results: A total of 21 cases met inclusion criteria: 9 successful laparoendoscopic THE procedures and 12 failed laparoendoscopic THE procedures (those requiring addition of a mini-laparotomy or thoracotomy). The mean mediastinal length for successful laparoendoscopic surgery was 23.5 cm, whereas the mean mediastinal length for failed laparoscopic surgeries was 24.8 cm (P = .03). Patient's overall height was not found to correlate with the need for conversion.Conclusions: Shorter mediastinal length is associated with successful laparoendoscopic or laparoscopic THE. This information is readily available to clinicians from routine preoperative staging studies (chest CT) and may be used to potentially predict the success rate of a totally laparoendoscopic approach and aid in patient selection. Further prospective evaluation of these findings is warranted. [ABSTRACT FROM AUTHOR]

Background: Laparoendoscopic transhiatal esophagectomy (THE) provides advantages over traditional THE by not only avoiding laparotomy but by also allowing more precise esophageal mobilization. Occasionally, the length of the gastric conduit is insufficient to allow delivery into the neck after laparoscopic mobilization and requires laparotomy to complete the procedure. We hypothesize that the need for laparotomy will correlate with the measurement of mediastinal height (distance from thoracic vertebrae T1-T12) on chest CT., Methods: Medical records of all patients who underwent attempted laparoendoscopic-assisted THE at a tertiary referral center between March 1, 2003 and January 31, 2019 were reviewed. Patients' mediastinal height was measured using computed tomography (CT) imaging of the chest by investigators and analyzed for correlation between mediastinal height and successful completion of a totally laparoendoscopic procedure., Results: A total of 21 cases met inclusion criteria: 9 successful laparoendoscopic THE procedures and 12 failed laparoendoscopic THE procedures (those requiring addition of a mini-laparotomy or thoracotomy). The mean mediastinal length for successful laparoendoscopic surgery was 23.5 cm, whereas the mean mediastinal length for failed laparoscopic surgeries was 24.8 cm (P = .03). Patient's overall height was not found to correlate with the need for conversion., Conclusions: Shorter mediastinal length is associated with successful laparoendoscopic or laparoscopic THE. This information is readily available to clinicians from routine preoperative staging studies (chest CT) and may be used to potentially predict the success rate of a totally laparoendoscopic approach and aid in patient selection. Further prospective evaluation of these findings is warranted.

Aim: We aim to study DNA methylation (DNAm) variations associated with childhood asthma., Methods: Nasal DNAm was compared between sibling pairs discordant for asthma, 29 sib pairs for genome-wide association studies and 54 sib pairs for verification by pyrosequencing. Associations of methylation with asthma symptoms, allergy and environmental exposures were evaluated. In vitro experiments and functional genomic analyses were performed to explore biologic relevance., Results: Three CpGs were associated with asthma. cg14830002 was associated with allergies in nonasthmatics. cg23602092 was associated with asthma symptoms. cg14830002 and cg23602092 were associated with traffic-related air pollution exposure. Nearby genes were transcriptionally regulated by diesel exhaust, house dust mite and 5-aza-2'-deoxycytidine. Active chromatin marks and transcription factor binding were found around these sites., Conclusion: We identified novel DNAm variations associated with childhood asthma and suggested new disease-contributing epigenetic mechanisms.