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2 results on '"Brendan Tarrier"'

1. Genome sequencing elucidates Sardinian genetic architecture and augments association analyses for lipid and blood inflammatory markers

Author

Nicholas J. Timpson, George Dedoussis, Brendan Tarrier, Alan Kwong, Gonçalo R. Abecasis, Charleston W. K. Chiang, Serena Sanna, Riccardo Berutti, Chris Jones, Andrea Angius, Eleftheria Zeggini, Ramaiah Nagaraja, Giorgio Pistis, Hyun Min Kang, Andrea Maschio, Maristella Steri, Paolo Gasparini, Eleonora Porcu, Silvia Naitza, Christine Brennan, Magdalena Zoledziewska, Carlo Sidore, Christian Fuchsberger, Francesco Cucca, Giovanni Malerba, Vicente Diego Ortega Del Vecchyo, Nicole Soranzo, Sergio Uzzau, Rossano Atzeni, Robert H. Lyons, Antonella Mulas, Jie Huang, John Novembre, Frederic Reinier, David Schlessinger, Jennifer L. Bragg-Gresham, Fabio Busonero, Fabrice Danjou, Daniela Toniolo, Maristella Pitzalis, Sidore, Carlo, Busonero, Fabio, Maschio, Andrea, Porcu, Eleonora, Naitza, Silvia, Zoledziewska, Magdalena, Mulas, Antonella, Pistis, Giorgio, Steri, Maristella, Danjou, Fabrice, Kwong, Alan, Del Vecchyo, Vicente Diego Ortega, Chiang, Charleston W. K., Bragg Gresham, Jennifer, Pitzalis, Maristella, Nagaraja, Ramaiah, Tarrier, Brendan, Brennan, Christine, Uzzau, Sergio, Fuchsberger, Christian, Atzeni, Rossano, Reinier, Frederic, Berutti, Riccardo, Huang, Jie, Timpson, Nicholas J., Toniolo, Daniela, Gasparini, Paolo, Malerba, Giovanni, Dedoussis, George, Zeggini, Eleftheria, Soranzo, Nicole, Jones, Chri, Lyons, Robert, Angius, Andrea, Kang, Hyun M., Novembre, John, Sanna, Serena, Schlessinger, David, Cucca, Francesco, Abecasis, Gonçalo R., Faculteit Medische Wetenschappen/UMCG, and Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI)

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Biomarkers, Female, Founder Effect, Gene Frequency, Genetics, Population, Genome, Human, Genome-Wide Association Study, Genotype, Geography, Haplotypes, Humans, Inflammation Mediators, Italy, Lipids, Male, Middle Aged, Polymorphism, Single Nucleotide, Sequence Analysis, DNA, Young Adult, Genetic Variation, Genetics, Haplotype, 80 and over, Non-U.S. Gov't, Inflammation Mediator, Exome sequencing, Genome, Research Support, Non-U.S. Gov't, Single Nucleotide, Lipid, Inflammatory biomarkers, Sequence Analysis, Human, Population, Biology, Research Support, DNA sequencing, Article, N.I.H, Research Support, N.I.H., Extramural, Journal Article, 1000 Genomes Project, Polymorphism, Genetic variants, Extramural, Biomarker, DNA, Genetic architecture, Founder effect
Abstract

We report similar to 17.6 million genetic variants from whole-genome sequencing of 2,120 Sardinians; 22% are absent from previous sequencing-based compilations and are enriched for predicted functional consequences. Furthermore, similar to 76,000 variants common in our sample (frequency >5%) are rare elsewhere (

Published
2015

2. Low pass DNA sequencing of 1,200 Sardinians reconstructs European Y chromosome phylogeny

Author

Rosella Pilu, Manuela Oppo, Carlo Sidore, Santos Alonso, Antonella Mulas, Antonella Useli, Gonçalo R. Abecasis, Mariano Dei, Magdalena Zoledziewska, Brendan Tarrier, Marco Marcelli, Sandra Lai, Roberto Cusano, Chris Jones, Bingshan Li, Francesca Deidda, Ilenia Zara, Sergio Uzzau, Serena Sanna, Eleonora Porcu, Fausto Pier'Angelo Poddie, Maria Francesca Urru, Rossano Atzeni, Andrea Angius, Michael B. Whalen, Andrea Maschio, Sergio Tofanelli, David Schlessinger, Paolo Francalacci, Jennifer Bragg Gresham, Laura Cornelia Clotilde Morelli, Fabio Busonero, Francesco Cucca, Robert H. Lyons, Maristella Pitzalis, Frederic Reinier, Hyun Min Kang, Daria Sanna, and Riccardo Berutti

Subjects
Male, Genetics, education.field_of_study, Mitochondrial DNA, Chromosomes, Human, Y, Multidisciplinary, Phylogenetic tree, Population, Haplotype, Genetic Variation, Biology, Y chromosome, Article, White People, Haplogroup, DNA sequencing, Evolution, Molecular, Genetic variation, Humans, Female, education
Abstract

Examining Y The evolution of human populations has long been studied with unique sequences from the nonrecombining, male-specific Y chromosome (see the Perspective by Cann ). Poznik et al. (p. 562 ) examined 9.9 Mb of the Y chromosome from 69 men from nine globally divergent populations—identifying population and individual specific sequence variants that elucidate the evolution of the Y chromosome. Sequencing of maternally inherited mitochondrial DNA allowed comparison between the relative rates of evolution, which suggested that the coalescence, or origin, of the human Y chromosome and mitochondria both occurred approximately 120 thousand years ago. Francalacci et al. (p. 565 ) investigated the sequence divergence of 1204 Y chromosomes that were sampled within the isolated and genetically informative Sardinian population. The sequence analyses, along with archaeological records, were used to calibrate and increase the resolution of the human phylogenetic tree.

Published
2013

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