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7. STROCSS 2019 Guideline: Strengthening the reporting of cohort studies in surgery

Author

Beamishaj, Bashashati, Mohammad, Millham, Frederick H., Orgill, Dennis P., Noureldin, Ashraf, Nixon, Iain James, Alsawadi, Abdulrahman, Bradley, Patrick J., Giordano, Salvatore, Laskin, Daniel M., Basu, Somprakas, Johnston, Maximilian, Muensterer, Oliver J., Mukherjee, Indraneil, Ngu, James Chi-Yong, Valmasoni, Michele, Pagano, Duilio, Vasudevan, Baskaran, Rosin, Richard David, McCaul, James Anthony, Albrecht, Jörg, Hoffman, Jerome R., Thorat, Mangesh A., Massarut, Samuele, Thoma, Achilles, Kirshtein, Boris, Afifi, Raafat Yahia, Farooq, Naheed, Challacombe, Ben, Pai, Prathamesh S., Perakath, Benjamin, Kadioglu, Huseyin, Aronson, Jeffrey K., Raveendran, Kandiah, Machado-Aranda, David, Klappenbach, Roberto, Healy, Donagh, Miguel, Diana, Leles, Claudio Rodrigues, Ather, M. Hammad, Agha, Riaz, Abdall-Razak, Ali, Crossley, Eleanor, Dowlut, Naeem, Iosifidis, Christos, and Mathew, Ginimol

Published
2019
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13. The STROCSS statement: Strengthening the Reporting of Cohort Studies in Surgery

Author

Pagano, Duilio, Pai, Prathamesh S., Basu, Somprakas, McCaul, Jim, Millham, Frederick, Vasudevan, Baskaran, Leles, Cláudio Rodrigues, Rosin, Richard David, Klappenbach, Roberto, Machado-Aranda, David A., Perakath, Benjamin, Beamish, Andrew J., Thorat, Mangesh A., Ather, M. Hammad, Farooq, Naheed, Laskin, Daniel M., Raveendran, Kandiah, Albrecht, Joerg, Milburn, James, Miguel, Diana, Mukherjee, Indraneil, Valmasoni, Michele, Ngu, James, Kirshtein, Boris, Raison, Nicholas, Boscoe, Michael, Johnston, Maximilian J., Hoffman, Jerome, Bashashati, Mohammad, Thoma, Achilleas, Healy, Donagh, Orgill, Dennis P., Giordano, Salvatore, Muensterer, Oliver J., Kadioglu, Hüseyin, Alsawadi, Abdulrahman, Bradley, Patrick J., Nixon, Iain James, Massarut, Samuele, Challacombe, Ben, Noureldin, Ashraf, Chalkoo, Mushtaq, Afifi, Raafat Yahia, Agha, Riaz Ahmed, Aronson, Jeffrey K., Pidgeon, Thomas E., Borrelli, Mimi R., Vella-Baldacchino, Martinique, and Thavayogan, Rachel

Published
2017
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17. Lymph Node Metastases from Non-Melanoma Skin Cancer of the Head and Neck †.

Author

Civantos, Francisco, Helmen, Zachary M., Bradley, Patrick J., Coca-Pelaz, Andrés, De Bree, Remco, Guntinas-Lichius, Orlando, Kowalski, Luiz P., López, Fernando, Mäkitie, Antti A., Rinaldo, Alessandra, Robbins, K. Thomas, Rodrigo, Juan P., Takes, Robert P., and Ferlito, Alfio

Subjects
LYMPH node surgery, SENTINEL lymph node biopsy, NECK surgery, MELANOMA, HEAD & neck cancer, METASTASIS, LYMPH nodes, SKIN tumors
Abstract

Simple Summary: Skin cancer, particularly non-melanoma skin cancer, is the most common malignancy in the world. There are both common and uncommon types that receive treatment every day. Despite their commonality, the management of each is not perfectly defined in the scientific literature. Many require surgical removal, but the management of regional metastasis (such as lymph nodes in the neck) may or may not require surgical removal, or even anything beyond observation. Further complicating matters, some may have microscopic regional metastases that cannot be detected with a physical exam or imaging. This article seeks to summarize the current literature on this topic and to offer specific insight on how to manage non-melanoma skin cancer that has migrated away from the primary site to the regional lymph nodes. Non-melanoma skin cancer (NMSC) represents the most common malignancy in the world, comprising exceedingly common lesions such as basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) and rare lesions such as Merkel cell carcinoma. Risk factors are widely recognized and include ultraviolet (UV) light exposure, radiation exposure, immunosuppression, and many others. As a whole, survival and functional outcomes are favorable, but each histopathological subtype of NMSC behaves differently. Treatment regimens for the primary site usually include wide surgical excision and neck dissection in cases of clinically involved metastatic lymph nodes. The elective management of draining nodal basins, however, is a contested topic. Nearly all subtypes, excluding BCC, have a significant risk of lymphatic metastases, and have been studied with regard to sentinel lymph node biopsy (SLNB) and elective neck dissection. To date, no studies have definitively established a true single standard of care, as exists for melanoma, for any of the NMSCs. As a result, the authors have sought to summarize the current literature and identify indications and management options for the management of the cervical lymphatics for each major subtype of NMSC. Further research remains critically necessary in order to develop complete treatment algorithms. [ABSTRACT FROM AUTHOR]

Published
2023
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18. Novel Imaging-Based Biomarkers for Identifying Carotid Plaque Vulnerability †.

Author

Fernández-Alvarez, Verónica, Linares-Sánchez, Miriam, Suárez, Carlos, López, Fernando, Guntinas-Lichius, Orlando, Mäkitie, Antti A., Bradley, Patrick J., and Ferlito, Alfio

Subjects
ATHEROSCLEROTIC plaque, CAROTID artery diseases, INTRAVASCULAR ultrasonography, CAROTID intima-media thickness, CAROTID artery, OPTICAL coherence tomography, MAGNETIC resonance imaging, CAROTID artery stenosis
Abstract

Carotid artery disease has traditionally been assessed based on the degree of luminal narrowing. However, this approach, which solely relies on carotid stenosis, is currently being questioned with regard to modern risk stratification approaches. Recent guidelines have introduced the concept of the "vulnerable plaque," emphasizing specific features such as thin fibrous caps, large lipid cores, intraplaque hemorrhage, plaque rupture, macrophage infiltration, and neovascularization. In this context, imaging-based biomarkers have emerged as valuable tools for identifying higher-risk patients. Non-invasive imaging modalities and intravascular techniques, including ultrasound, computed tomography, magnetic resonance imaging, intravascular ultrasound, optical coherence tomography, and near-infrared spectroscopy, have played pivotal roles in characterizing and detecting unstable carotid plaques. The aim of this review is to provide an overview of the evolving understanding of carotid artery disease and highlight the significance of imaging techniques in assessing plaque vulnerability and informing clinical decision-making. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Adenoid cystic carcinoma of the head and neck – An update

Author

Coca-Pelaz, Andrés, Rodrigo, Juan P., Bradley, Patrick J., Vander Poorten, Vincent, Triantafyllou, Asterios, Hunt, Jennifer L., Strojan, Primož, Rinaldo, Alessandra, Haigentz, Missak, Jr., Takes, Robert P., Mondin, Vanni, Teymoortash, Afshin, Thompson, Lester D.R., and Ferlito, Alfio

Published
2015
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20. Efficacy of Larynx Preservation Surgery and Multimodal Adjuvant Therapy for Hypopharyngeal Cancer: A Case Series Study.

Author

Li, Wan-Xin, Dong, Yan-Bo, Lu, Cheng, Bradley, Patrick J., and Liu, Liang-Fa

Subjects
LARYNGEAL surgery, ACADEMIC medical centers, CONFIDENCE intervals, DEGLUTITION, CANCER chemotherapy, LOG-rank test, RETROSPECTIVE studies, HEALTH outcome assessment, ADJUVANT treatment of cancer, CHEMORADIOTHERAPY, PRESERVATION of organs, tissues, etc., SURVIVAL rate, TREATMENT effectiveness, FUNCTIONAL assessment, RESEARCH funding, COMBINED modality therapy, RADIOTHERAPY, HYPOPHARYNGEAL cancer, LONGITUDINAL method, INDUCTION chemotherapy
Abstract

Background: Larynx preservation surgery (LPS) combined with multimodal adjuvant therapy (MAT) is re-emerging as treatment option for hypopharyngeal cancer (HPC). This study aims to explore the survival and functional outcome of this combined approach. Methods: This is a retrospective cohort study. Selected patients with primary HPC treated by LPS and MAT at two large Beijing medical centers between 2005 and 2019 were included. In addition to LPS, patients received one or more of the following treatments: preoperative induction chemotherapy, postoperative intensity-modulated radiotherapy, chemotherapy, or targeted therapy. Results: In total, 64 patients were included (62 were men, and median age was 57.5 years). The disease in most patients was in stage III (28.1%) or IV (56.3%), or in stage T2 (34.4%) or T3 (45.3%), based on the TNM scale. Across all patients, the rate of overall survival (OS) was 60.7% at 3 yr and 47.3% at 5 yr. OS was significantly higher for patients with stage I or II disease than for those with stage III or IV disease (HR 8.64, 95% CI 3.69–20.2, log-rank P =.010). Decannulation was successful in 55 patients (85.9%), and swallowing function was satisfactory (stage 0–III, on Functional Outcome Swallowing Scale) for 50 (78.1%). Median Voice Handicap Index-10 score on voice performance was 19 (range 4–40), and median Functional Assessment of Cancer Therapy-General Questionnaire score for QoL was 75 (range 16–105). Conclusions: LPS and MAT can provide satisfactory oncologic control and good functional outcomes for selected patients with HPC, especially those with stage I or II disease. [ABSTRACT FROM AUTHOR]

Published
2023
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22. Cervical Lymph Node Metastasis in Adenoid Cystic Carcinoma of the Larynx: A Collective International Review

Author

Coca-Pelaz, Andrés, Barnes, Leon, Rinaldo, Alessandra, Cardesa, Antonio, Shah, Jatin P., Rodrigo, Juan P., Suárez, Carlos, Eloy, Jean Anderson, Bishop, Justin A., Devaney, Kenneth O., Thompson, Lester D. R., Wenig, Bruce M., Strojan, Primož, Hamoir, Marc, Bradley, Patrick J., Gnepp, Douglas R., Silver, Carl E., Slootweg, Pieter J., Triantafyllou, Asterios, Vander Poorten, Vincent, Williams, Michelle D., Skálová, Alena, Hellquist, Henrik, Teymoortash, Afshin, Medina, Jesus E., Robbins, K. Thomas, Pitman, Karen T., Kowalski, Luiz P., de Bree, Remco, Mendenhall, William M., Takes, Robert P., and Ferlito, Alfio

Published
2016
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23. Cervical Lymph Node Metastasis in High-Grade Transformation of Head and Neck Adenoid Cystic Carcinoma: A Collective International Review

Author

Hellquist, Henrik, Skálová, Alena, Barnes, Leon, Cardesa, Antonio, Thompson, Lester D. R., Triantafyllou, Asterios, Williams, Michelle D., Devaney, Kenneth O., Gnepp, Douglas R., Bishop, Justin A., Wenig, Bruce M., Suárez, Carlos, Rodrigo, Juan P., Coca-Pelaz, Andrés, Strojan, Primož, Shah, Jatin P., Hamoir, Marc, Bradley, Patrick J., Silver, Carl E., Slootweg, Pieter J., Vander Poorten, Vincent, Teymoortash, Afshin, Medina, Jesus E., Robbins, K. Thomas, Pitman, Karen T., Kowalski, Luiz P., de Bree, Remco, Mendenhall, William M., Eloy, Jean Anderson, Takes, Robert P., Rinaldo, Alessandra, and Ferlito, Alfio

Published
2016
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26. Causes of death of patients with laryngeal cancer

Author

Ferlito, Alfio, Haigentz, Jr., Missak, Bradley, Patrick J., Suárez, Carlos, Strojan, Primož, Wolf, Gregory T., Olsen, Kerry D., Mendenhall, William M., Mondin, Vanni, Rodrigo, Juan P., Boedeker, Carsten C., Hamoir, Marc, Hartl, Dana M., Hunt, Jennifer L., Devaney, Kenneth O., Thompson, Lester D. R., Rinaldo, Alessandra, and Takes, Robert P.

Published
2014
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27. Cervical lymph node metastases from remote primary tumor sites

Author

López, Fernando, Rodrigo, Juan P., Silver, Carl E., Haigentz, Missak, Jr, Bishop, Justin A., Strojan, Primož, Hartl, Dana M., Bradley, Patrick J., Mendenhall, William M., Suárez, Carlos, Takes, Robert P., Hamoir, Marc, Robbins, Thomas K., Shaha, Ashok R., Werner, Jochen A., Rinaldo, Alessandra, Ferlito, Alfio, and Eisele, David

Published
2016
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30. Survival and swallowing function outcome impact factors analysis of surgery-oriented comprehensive treatment for hypopharyngeal cancer in a series of 122 patients.

Author

Li, Wan-Xin, Dong, Yan-Bo, Lu, Cheng, Bradley, Patrick J., and Liu, Liang-Fa

Subjects
TRACHEOTOMY, SKIN diseases, DEGLUTITION, PHARYNGEAL diseases, FISTULA, FUNCTIONAL status, MULTIVARIATE analysis, RETROSPECTIVE studies, CANCER relapse, METASTASIS, TREATMENT effectiveness, CANCER patients, FEEDING tubes, QUALITY of life, SURVIVAL analysis (Biometry), LOGISTIC regression analysis, PROGRESSION-free survival, HYPOPHARYNGEAL cancer, LONGITUDINAL method, PROPORTIONAL hazards models, EVALUATION
Abstract

Objective: Under current standards of treating highly aggressive hypopharyngeal cancer (HPC), oncological control and functional outcome are still unsatisfactory worldwide. This study explored the surgery-oriented comprehensive treatment approach based on 15 years of practice. Methods: A retrospective cohort of HPC patients treated by the senior author at Chinese PLA General Hospital between Nov 2005 and Aug 2012 and Capital Medical University Beijing Friendship Hospital between May 2014 and Nov 2019 was studied. Oncological control, swallowing function, and quality of life (QoL) were assessed. Results: In total, 122 patients were included in this study, with 11 (9.0%) cases in the early stage and 111 (91.0%) cases in the advanced stage. Five-year overall survival (OS) and disease-free survival (DFS) were 40.0% and 36.1%, respectively. The swallowing outcome was satisfactory in 90 (73.8%) patients. Tracheostomy-free survival was achieved in 55 (45.1%) patients. Multivariate cox regression analysis showed that the size of the surgical defect, local-regional recurrence, and distant metastasis were independent impact factors for OS and DFS (P <.05). Multivariate analysis showed that the logistic regression coefficients (standard error) of pharyngo-cutaneous fistula and local-regional recurrence on swallowing function were 1.274 (.532) and 1.283 (.496), respectively (P <.05). In addition, the logistic regression coefficients (standard error) of the clinical stage, local-regional recurrence, decannulation, and feeding tube on QoL were −7.803 (3.593), −7.699 (3.151), 13.853 (3.494), and −20.243 (3.696), respectively (P <.05). Conclusions: Surgery-oriented comprehensive treatment can give rise to good swallowing function without jeopardizing oncological control. The size of the surgical defect, local-regional recurrence, and distant metastasis were independent factors impacting OS and DFS. Pharyngo-cutaneous fistula and local-regional recurrence were independent factors impacting swallowing function. Clinical stage, local-regional recurrence, decannulation, and feeding tube were independent factors impacting QoL. [ABSTRACT FROM AUTHOR]

Published
2022
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32. Limits They Can Live With

Author

Strum, Marie T., Bills, Gerald L., Dupuis, Thomas V., Cotnoir, David J., and Bradley, Patrick J.

Published
1998

45. Management of the N0 neck—reference or preference

Author

Wei, William I., Ferlito, Alfio, Rinaldo, Alessandra, Gourin, Christine G., Lowry, John, Ho, Wai Kuen, Leemans, C. René, Shaha, Ashok R., Suárez, Carlos, Clayman, Gary L., Robbins, K. Thomas, Bradley, Patrick J., and Silver, Carl E.

Published
2006
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