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1. A chemical survey of exoplanets with ARIEL

Author

Tinetti, Giovanna, Drossart, Pierre, Eccleston, Paul, Hartogh, Paul, Heske, Astrid, Leconte, Jérémy, Micela, Giusi, Ollivier, Marc, Pilbratt, Göran, Puig, Ludovic, Turrini, Diego, Vandenbussche, Bart, Wolkenberg, Paulina, Beaulieu, Jean-Philippe, Buchave, Lars A., Ferus, Martin, Griffin, Matt, Guedel, Manuel, Justtanont, Kay, Lagage, Pierre-Olivier, Machado, Pedro, Malaguti, Giuseppe, Min, Michiel, Nørgaard-Nielsen, Hans Ulrik, Rataj, Mirek, Ray, Tom, Ribas, Ignasi, Swain, Mark, Szabo, Robert, Werner, Stephanie, Barstow, Joanna, Burleigh, Matt, Cho, James, du Foresto, Vincent Coudé, Coustenis, Athena, Decin, Leen, Encrenaz, Therese, Galand, Marina, Gillon, Michael, Helled, Ravit, Morales, Juan Carlos, Muñoz, Antonio García, Moneti, Andrea, Pagano, Isabella, Pascale, Enzo, Piccioni, Giuseppe, Pinfield, David, Sarkar, Subhajit, Selsis, Franck, Tennyson, Jonathan, Triaud, Amaury, Venot, Olivia, Waldmann, Ingo, Waltham, David, Wright, Gillian, Amiaux, Jerome, Auguères, Jean-Louis, Berthé, Michel, Bezawada, Naidu, Bishop, Georgia, Bowles, Neil, Coffey, Deirdre, Colomé, Josep, Crook, Martin, Crouzet, Pierre-Elie, Da Peppo, Vania, Sanz, Isabel Escudero, Focardi, Mauro, Frericks, Martin, Hunt, Tom, Kohley, Ralf, Middleton, Kevin, Morgante, Gianluca, Ottensamer, Roland, Pace, Emanuele, Pearson, Chris, Stamper, Richard, Symonds, Kate, Rengel, Miriam, Renotte, Etienne, Ade, Peter, Affer, Laura, Alard, Christophe, Allard, Nicole, Altieri, Francesca, André, Yves, Arena, Claudio, Argyriou, Ioannis, Aylward, Alan, Baccani, Cristian, Bakos, Gaspar, Banaszkiewicz, Marek, Barlow, Mike, Batista, Virginie, Bellucci, Giancarlo, Benatti, Serena, Bernardi, Pernelle, Bézard, Bruno, Blecka, Maria, Bolmont, Emeline, Bonfond, Bertrand, Bonito, Rosaria, Bonomo, Aldo S., Brucato, John Robert, Brun, Allan Sacha, Bryson, Ian, Bujwan, Waldemar, Casewell, Sarah, Charnay, Bejamin, Pestellini, Cesare Cecchi, Chen, Guo, Ciaravella, Angela, Claudi, Riccardo, Clédassou, Rodolphe, Damasso, Mario, Damiano, Mario, Danielski, Camilla, Deroo, Pieter, Di Giorgio, Anna Maria, Dominik, Carsten, Doublier, Vanessa, Doyle, Simon, Doyon, René, Drummond, Benjamin, Duong, Bastien, Eales, Stephen, Edwards, Billy, Farina, Maria, Flaccomio, Ettore, Fletcher, Leigh, Forget, François, Fossey, Steve, Fränz, Markus, Fujii, Yuka, García-Piquer, Álvaro, Gear, Walter, Geoffray, Hervé, Gérard, Jean Claude, Gesa, Lluis, Gomez, H., Graczyk, Rafał, Griffith, Caitlin, Grodent, Denis, Guarcello, Mario Giuseppe, Gustin, Jacques, Hamano, Keiko, Hargrave, Peter, Hello, Yann, Heng, Kevin, Herrero, Enrique, Hornstrup, Allan, Hubert, Benoit, Ida, Shigeru, Ikoma, Masahiro, Iro, Nicolas, Irwin, Patrick, Jarchow, Christopher, Jaubert, Jean, Jones, Hugh, Julien, Queyrel, Kameda, Shingo, Kerschbaum, Franz, Kervella, Pierre, Koskinen, Tommi, Krijger, Matthijs, Krupp, Norbert, Lafarga, Marina, Landini, Federico, Lellouch, Emanuel, Leto, Giuseppe, Luntzer, A., Rank-Lüftinger, Theresa, Maggio, Antonio, Maldonado, Jesus, Maillard, Jean-Pierre, Mall, Urs, Marquette, Jean-Baptiste, Mathis, Stephane, Maxted, Pierre, Matsuo, Taro, Medvedev, Alexander, Miguel, Yamila, Minier, Vincent, Morello, Giuseppe, Mura, Alessandro, Narita, Norio, Nascimbeni, Valerio, Nguyen Tong, N., Noce, Vladimiro, Oliva, Fabrizio, Palle, Enric, Palmer, Paul, Pancrazzi, Maurizio, Papageorgiou, Andreas, Parmentier, Vivien, Perger, Manuel, Petralia, Antonino, Pezzuto, Stefano, Pierrehumbert, Ray, Pillitteri, Ignazio, Piotto, Giampaolo, Pisano, Giampaolo, Prisinzano, Loredana, Radioti, Aikaterini, Réess, Jean-Michel, Rezac, Ladislav, Rocchetto, Marco, Rosich, Albert, Sanna, Nicoletta, Santerne, Alexandre, Savini, Giorgio, Scandariato, Gaetano, Sicardy, Bruno, Sierra, Carles, Sindoni, Giuseppe, Skup, Konrad, Snellen, Ignas, Sobiecki, Mateusz, Soret, Lauriane, Sozzetti, Alessandro, Stiepen, A., Strugarek, Antoine, Taylor, Jake, Taylor, William, Terenzi, Luca, Tessenyi, Marcell, Tsiaras, Angelos, Tucker, C., Valencia, Diana, Vasisht, Gautam, Vazan, Allona, Vilardell, Francesc, Vinatier, Sabrine, Viti, Serena, Waters, Rens, Wawer, Piotr, Wawrzaszek, Anna, Whitworth, Anthony, Yung, Yuk L., Yurchenko, Sergey N., Osorio, María Rosa Zapatero, Zellem, Robert, Zingales, Tiziano, and Zwart, Frans

Published
2018
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5. Cyclic GMP alters the firing rate and thermosensitivity of hypothalamic neurons

Author

Wright, Chadwick L., Burgoon, Penny W., Bishop, Georgia A., and Boulant, Jack A.

Subjects
Immunohistochemistry -- Research, Electrophysiology -- Research, Purine nucleotides -- Influence, Purine nucleotides -- Properties, Hypothalamus -- Properties, Neurons -- Properties, Biological sciences
Abstract

The rostral hypothalamus, especially the preoptic-anterior hypothalamus (POAH), contains temperature-sensitive and -insensitive neurons that form synaptic networks to control thermoregulatory responses. Previous studies suggest that the cyclic nucleotide cGMP is an important mediator in this neuronal network, since hypothalamic microinjections of cGMP analogs produce hypothermia in several species. In the present study, immunohistochemisty showed that rostral hypothalamic neurons contain cGMP, guanylate cyclase (necessary for cGMP synthesis), and CNG A2 (an important cyclic nucleotide-gated channel). Extracellular electrophysiological activity was recorded from different types of neurons in rat hypothalamic tissue slices. Each recorded neuron was classified according to its thermosensitivity as well as its firing rate response to 2-100 [micro]M 8-bromo-cGMP (a membrane-permeable cGMP analog), cGMP has specific effects on different neurons in the rostral hypothalamus. In the POAH, the cGMP analog decreased the spontaneous firing rate in 45% of temperature-sensitive and -insensitive neurons, an effect that is likely due to cGMP-enhanced hyperpolarizing [K.sup.+] currents. This decreased POAH activity could attenuate thermoregulatory responses and produce hypothermia during exposures to cool or neutral ambient temperatures. Although 8-bromo-cGMP did not affect the thermosensitivity of most POAH neurons, it did increase the warm sensitivity of neurons in other hypothalamic regions located dorsal, lateral, and posterior to the POAH. This increased thermosensitivity may be due to pacemaker currents that are facilitated by cyclic nucleotides, if some of these non-POAH thermosensitive neurons promote heat loss or inhibit heat production, then their increased thermosensitivity could contribute to cGMP-induced decreases in body temperature. guanosine monophosphate; neuronal activity: soluble guanylate cyclase; cyclic nucleotide-gated channel; immunohistochemistry: electrophysiology

Published
2008

6. Ionic channels and conductance-based models for hypothalamic neuronal thermosensitivity

Author

Wechselberger, Martin, Wright, Chadwick L., Bishop, Georgia A., and Boulant, Jack A.

Subjects
Potassium channels -- Research, Hypothalamus -- Research, Biological sciences
Abstract

Thermoregulatory responses are partially controlled by the preoptic area and anterior hypothalamus (PO/AH), which contains a mixed population of temperature-sensitive and insensitive neurons. Immunohistochemical procedures identified the extent of various ionic channels in rat PO/AH neurons. These included pacemaker current channels [i.e., hyperpolarization-activated cyclic nucleotide-gated channels (HCN)], background potassium leak channels (TASK-1 and TRAAK), and transient receptor potential channel (TRP) TRPV4. PO/AH neurons showed dense TASK-1 and HCN-2 immunoreactivity and moderate TRAAK and HCN-4 immunoreactivity. In contrast, the neuronal cell bodies did not label for TRPV4, but instead, punctate labeling was observed in traversing axons or their terminal endings. On the basis of these results and previous electrophysiological studies, Hodgkin-Huxley-like models were constructed. These models suggest that most PO/AH neurons have the same types of ionic channels, but different levels of channel expression can explain the inherent properties of the various types of temperature-sensitive and insensitive neurons. Hodgkin-Huxley formalism; cationic channels; potassium leak currents doi:10.1152/ajpregu.00039.2006.

Published
2006

13. First lab results of the WEAVE fibre positioner system

Author

Schallig, Ellen, Dalton, Gavin, Lewis, Ian, Brock, Matthew, Abrams, Don Carlos, Middleton, Kevin, Bishop, Georgia, L. Aguerri, J. Alfonso, Bonifacio, Piercarlo, Carrasco Licea, Esperanza, Trager, Scott, Vallenari, Antonella, Terrett, David, Takami, Hideki, Evans, Christopher, Simard, Luc, Cosmological Impact of the FIrst STars (CIFIST), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Department of Psychiatry and Biobehavioral Sciences, University of California [Los Angeles] (UCLA), University of California-University of California-Shirley and Stefan Hatos Center for Neuropharmacology, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, and University of California (UC)-University of California (UC)-Shirley and Stefan Hatos Center for Neuropharmacology

Subjects
[SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

17. An integrated payload design for the Atmospheric Remote-sensing Infrared Exoplanet Large-survey (ARIEL): Results from phase A and forward look to phase B1.

Author

Middleton, Kevin F., Tinetti, Giovanna, Beaulieu, Jean-Philippe, Güdel, Manuel, Hartogh, Paul, Eccleston, Paul, Micela, Giuseppina, Min, Michiel, Rataj, Miroslaw, Ray, Tom, Ribas, Ignasi, Vandenbussche, Bart, Auguères, Jean-Louis, Bishop, Georgia, Da Deppo, Vania, Sanz, Isabel Escudero, Focardi, Mauro, Hunt, Thomas, Malaguti, Giuseppe, and Morgante, Gianluca

Published
2019

28. Optimisation of the WEAVE target assignment algorithm.

Author

Hughes, Sarah, Dalton, Gavin, Smith, Daniel, Duncan, Kenneth, Terrett, David, Abrams, Don Carlos, Aguerri, J. Alfonso, Balcells, Marc, Bishop, Georgia, Bonifacio, Piercarlo, Carrasco, Esperanza, Jin, Shoko, Lewis, Ian, Trager, Scott, and Vallenari, Antonella

Published
2022
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30. Ground calibration of the Ariel space telescope: optical ground support equipment design and description.

Author

Bowles, Neil E., Abreu, Manuel, van Kempen, Tim A., Krijger, Matthijs, Spry, Robert, Evans, Rory, Watkins, Robert A., Pereira, Cédric, Pascale, E., Eccleston, Paul, Pearson, Chris, Desjonquères, Lucile, Bishop, Georgia, Caldwell, Andrew, Moneti, Andrea, Focardi, Mauro, Sarkar, Subhajit, Malaguti, Giuseppe, Argyriou, Ioannis, and Nowicki, Keith

Published
2022
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42. A chemical survey of exoplanets with ARIEL

Author

Tinetti, Giovanna, Drossart, Pierre, Eccleston, Paul, Hartogh, Paul, Heske, Astrid, Leconte, Jérémy, Micela, Giusi, Ollivier, Marc, Pilbratt, Göran, Puig, Ludovic, Turrini, Diego, Vandenbussche, Bart, Wolkenberg, Paulina, Beaulieu, Jean-Philippe, Buchave, Lars A., Ferus, Martin, Griffin, Matt, Guedel, Manuel, Justtanont, Kay, Lagage, Pierre-Olivier, Machado, Pedro, Malaguti, Giuseppe, Min, Michiel, Nørgaard-Nielsen, Hans Ulrik, Rataj, Mirek, Ray, Tom, Ribas, Ignasi, Swain, Mark, Szabo, Robert, Werner, Stephanie, Barstow, Joanna, Burleigh, Matt, Cho, James, Du Foresto, Vincent Coudé, Coustenis, Athena, Decin, Leen, Encrenaz, Therese, Galand, Marina, Gillon, Michael, Helled, Ravit, Morales, Juan Carlos, Muñoz, Antonio García, Moneti, Andrea, Pagano, Isabella, Pascale, Enzo, Piccioni, Giuseppe, Pinfield, David, Sarkar, Subhajit, Selsis, Franck, Tennyson, Jonathan, Triaud, Amaury, Venot, Olivia, Waldmann, Ingo, Waltham, David, Wright, Gillian, Amiaux, Jerome, Auguères, Jean-Louis, Berthé, Michel, Bezawada, Naidu, Bishop, Georgia, Bowles, Neil, Coffey, Deirdre, Colomé, Josep, Crook, Martin, Crouzet, Pierre-Elie, Da Peppo, Vania, Sanz, Isabel Escudero, Focardi, Mauro, Frericks, Martin, Hunt, Tom, Kohley, Ralf, Middleton, Kevin, Morgante, Gianluca, Ottensamer, Roland, Pace, Emanuele, Pearson, Chris, Stamper, Richard, Symonds, Kate, Rengel, Miriam, Renotte, Etienne, Ade, Peter, Affer, Laura, Alard, Christophe, Allard, Nicole, Altieri, Francesca, André, Yves, Arena, Claudio, Argyriou, Ioannis, Aylward, Alan, Baccani, Cristian, Bakos, Gaspar, Banaszkiewicz, Marek, Barlow, Mike, Batista, Virginie, Bellucci, Giancarlo, Benatti, Serena, Bernardi, Pernelle, Bézard, Bruno, Blecka, Maria, Bolmont, Emeline, Bonfond, Bertrand, Bonito, Rosaria, Bonomo, Aldo S., Brucato, John Robert, Brun, Allan Sacha, Bryson, Ian, Bujwan, Waldemar, Casewell, Sarah, Charnay, Bejamin, Pestellini, Cesare Cecchi, Chen, Guo, Ciaravella, Angela, Claudi, Riccardo, Clédassou, Rodolphe, Damasso, Mario, Damiano, Mario, Danielski, Camilla, Deroo, Pieter, Di Giorgio, Anna Maria, Dominik, Carsten, Doublier, Vanessa, Doyle, Simon, Doyon, René, Drummond, Benjamin, Duong, Bastien, Eales, Stephen, Edwards, Billy, Farina, Maria, Flaccomio, Ettore, Fletcher, Leigh, Forget, François, Fossey, Steve, Fränz, Markus, Fujii, Yuka, García-Piquer, Álvaro, Gear, Walter, Geoffray, Hervé, Gérard, Jean Claude, Gesa, Lluis, Gomez, H., Graczyk, Rafał, Griffith, Caitlin, Grodent, Denis, Guarcello, Mario Giuseppe, Gustin, Jacques, Hamano, Keiko, Hargrave, Peter, Hello, Yann, Heng, Kevin, Herrero, Enrique, Hornstrup, Allan, Hubert, Benoit, Ida, Shigeru, Ikoma, Masahiro, Iro, Nicolas, Irwin, Patrick, Jarchow, Christopher, Jaubert, Jean, Jones, Hugh, Julien, Queyrel, Kameda, Shingo, Kerschbaum, Franz, Kervella, Pierre, Koskinen, Tommi, Krijger, Matthijs, Krupp, Norbert, Lafarga, Marina, Landini, Federico, Lellouch, Emanuel, Leto, Giuseppe, Luntzer, A., Rank-Lüftinger, Theresa, Maggio, Antonio, Maldonado, Jesus, Maillard, Jean-Pierre, Mall, Urs, Marquette, Jean-Baptiste, Mathis, Stephane, Maxted, Pierre, Matsuo, Taro, Medvedev, Alexander, Miguel, Yamila, Minier, Vincent, Morello, Giuseppe, Mura, Alessandro, Narita, Norio, Nascimbeni, Valerio, Nguyen Tong, N., Noce, Vladimiro, Oliva, Fabrizio, Palle, Enric, Palmer, Paul, Pancrazzi, Maurizio, Papageorgiou, Andreas, Parmentier, Vivien, Perger, Manuel, Petralia, Antonino, Pezzuto, Stefano, Pierrehumbert, Ray, Pillitteri, Ignazio, Piotto, Giampaolo, Pisano, Giampaolo, Prisinzano, Loredana, Radioti, Aikaterini, Réess, Jean-Michel, Rezac, Ladislav, Rocchetto, Marco, Rosich, Albert, Sanna, Nicoletta, Santerne, Alexandre, Savini, Giorgio, Scandariato, Gaetano, Sicardy, Bruno, Sierra, Carles, Sindoni, Giuseppe, Skup, Konrad, Snellen, Ignas, Sobiecki, Mateusz, Soret, Lauriane, Sozzetti, Alessandro, Stiepen, A., Strugarek, Antoine, Taylor, Jake, Taylor, William, Terenzi, Luca, Tessenyi, Marcell, Tsiaras, Angelos, Tucker, C., Valencia, Diana, Vasisht, Gautam, Vazan, Allona, Vilardell, Francesc, Vinatier, Sabrine, Viti, Serena, Waters, Rens, Wawer, Piotr, Wawrzaszek, Anna, Whitworth, Anthony, Yung, Yuk L., Yurchenko, Sergey N., Osorio, María Rosa Zapatero, Zellem, Robert, Zingales, Tiziano, and Zwart, Frans

Subjects
13. Climate action, 530 Physics, 520 Astronomy, Astrophysics::Earth and Planetary Astrophysics, 500 Science, 7. Clean energy
Abstract

Thousands of exoplanets have now been discovered with a huge range of masses, sizes and orbits: from rocky Earth-like planets to large gas giants grazing the surface of their host star. However, the essential nature of these exoplanets remains largely mysterious: there is no known, discernible pattern linking the presence, size, or orbital parameters of a planet to the nature of its parent star. We have little idea whether the chemistry of a planet is linked to its formation environment, or whether the type of host star drives the physics and chemistry of the planet’s birth, and evolution. ARIEL was conceived to observe a large number (~1000) of transiting planets for statistical understanding, including gas giants, Neptunes, super-Earths and Earth-size planets around a range of host star types using transit spectroscopy in the 1.25–7.8 μm spectral range and multiple narrow-band photometry in the optical. ARIEL will focus on warm and hot planets to take advantage of their well-mixed atmospheres which should show minimal condensation and sequestration of high-Z materials compared to their colder Solar System siblings. Said warm and hot atmospheres are expected to be more representative of the planetary bulk composition. Observations of these warm/hot exoplanets, and in particular of their elemental composition (especially C, O, N, S, Si), will allow the understanding of the early stages of planetary and atmospheric formation during the nebular phase and the following few million years. ARIEL will thus provide a representative picture of the chemical nature of the exoplanets and relate this directly to the type and chemical environment of the host star. ARIEL is designed as a dedicated survey mission for combined-light spectroscopy, capable of observing a large and well-defined planet sample within its 4-year mission lifetime. Transit, eclipse and phase-curve spectroscopy methods, whereby the signal from the star and planet are differentiated using knowledge of the planetary ephemerides, allow us to measure atmospheric signals from the planet at levels of 10–100 part per million (ppm) relative to the star and, given the bright nature of targets, also allows more sophisticated techniques, such as eclipse mapping, to give a deeper insight into the nature of the atmosphere. These types of observations require a stable payload and satellite platform with broad, instantaneous wavelength coverage to detect many molecular species, probe the thermal structure, identify clouds and monitor the stellar activity. The wavelength range proposed covers all the expected major atmospheric gases from e.g. H₂O, CO₂, CH₄ NH₃, HCN, H₂S through to the more exotic metallic compounds, such as TiO, VO, and condensed species. Simulations of ARIEL performance in conducting exoplanet surveys have been performed – using conservative estimates of mission performance and a full model of all significant noise sources in the measurement – using a list of potential ARIEL targets that incorporates the latest available exoplanet statistics. The conclusion at the end of the Phase A study, is that ARIEL – in line with the stated mission objectives – will be able to observe about 1000 exoplanets depending on the details of the adopted survey strategy, thus confirming the feasibility of the main science objectives.

43. Role of hyperpolarization-activated currents in hypothalamic neuronal thermosensitivity.

Author

Unger, Nicholas T., Kaple, Mary L., Bishop, Georgia A., and Boulant, Jack A.

Subjects
HYPOTHALAMUS, NEURONS, CATIONS, CYCLIC nucleotides, TEMPERATURE, PACEMAKER cells
Abstract

The thermoregulatory preoptic-anterior hypothalamus (POAH) contains both temperature sensitive and insensitive neurons. Our previous studies predict that neuronal warm-sensitivity is due to thermosensitive pacemaker currents that include both the inactivation of transient outward K+ currents and the activation of Ih (cation currents activated by hyperpolarization). The latter include inward currents through hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. Our recent modeling study (Wechselberger et al, Am. J. Physiol. 2006) predicts that HCN channels contribute to neuronal warm-sensitivity, while K+ leak channels contribute to temperature insensitivity. Since POAH neurons show differences in their HCN immunoreactivity, the present study tested the models' predictions by measuring Ih in different types of POAH neurons recorded in rat hypothalamic tissue slices. During current-clamp recordings, each neuron was characterized by its spontaneous activity at 36°C and by its firing rate thermosensitivity (impulses/sec/°C) when the tissue slice was warmed and cooled. Voltage-clamp recordings measured Ih and the effects of temperature on this current. In support of the models' predictions, our experiments to date indicate that Ih is often associated with neurons displaying pacemaker activity and warm-sensitivity. [ABSTRACT FROM AUTHOR]

Published
2007
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