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11. The impact of ethnicity on lipoproteins in coronary artery disease

Author

Bhandari, Sanjay, Ng, Leong, and Jones, Don

Subjects
616.1
Abstract

Coronary artery disease (CAD) is a leading cause of mortality in the UK, with individuals of South Asian origin at intensified risk, owing to a higher prevalence of diabetes, culminating in an atherogenic phenotype. The epidemiological evidence supporting a protective role for high density lipoprotein-cholesterol in CAD, has failed to be realised in the ILLUMINATE/AIM-high trials. The paradigm has shifted towards an appreciation of the quality of the lipoprotein particles, rather than arbitrary levels. Lipoproteins contain unique protein cargoes, mediating roles in coagulation, redox and inflammation. The objective of this study was to explore differences in the low abundant protein cargo of lipoproteins between South Asian and Caucasian patients with CAD, to further understand the differential risk. A novel lipoaffinity resin was explored and optimised for efficient and reliable lipoprotein pull-down from plasma. Samples were analysed using a label-free bottom-up proteomic approach on an ion-mobility enabled mass spectrometer. Statins remain the cornerstone for prevention of CAD. In a sub-study, statin therapy was associated with the modulation of proteins concerned with the cytoskeletal architecture, cell proliferation and inflammation, in patients with hypercholesterolemia. The controversial link between statin use and new onset diabetes may be explained a depletion of adipsin, a potent insulin secretagogue. In a further sub-study, lipoproteins of CAD patients were enriched with pro-inflammatory mediators compared with age and sex matched controls. A model comprising of 7 proteins accurately predicted CAD status. In the discovery study, lipoproteins of South Asians were enriched with pro-thrombotic and pro-inflammatory mediators, compared with sex-matched Caucasians with stable CAD. Plasma carboxypeptidase B2 was significantly higher in South Asians compared to Caucasians with CAD in verification studies, contributing to impaired fibrinolysis and potentially to their excess risk. The lipoproteomic cargo undergoes subtle changes in CAD, with various dysregulated proteins independently influenced by ethnicity.

Published
2017

13. Understanding the Relationship Between Wealth and Cognitive Function by Race/Ethnicity Among Older United States Adults with Diabetes.

Author

Papadimitriou, Amelia, Dawson, Aprill Z., Thorgerson, Abigail, Bhandari, Sanjay, Martinez, Martin, and Egede, Leonard E.

Subjects
RACE, COGNITIVE ability, ETHNICITY, ALZHEIMER'S disease, GENERALIZED estimating equations, MILD cognitive impairment
Abstract

Background: The prevalence of type 2 diabetes is increasing with the burden disproportionately falling on older adults and racial/ethnic minorities. Older adults with diabetes show greater cognitive decline and there are disparities in cognitive function by race/ethnicity that can be explained by social determinants such as wealth. Objective: To understand whether there is a differential relationship between wealth and cognitive function by race/ethnicity among older U.S. adults with diabetes. Methods: Data on 9,006 adults aged 50+ with diabetes from the Health and Retirement Study (2006–2016) were analyzed. The primary outcome, cognitive function, was a score ranging from range 0–27 categorized as: normal [12–27], mild cognitive impairment (MCI) [7–11], and dementia including Alzheimer's disease [0–6]. Three modeled outcomes were: 1) normal versus MCI, 2) normal versus dementia, 3) MCI versus dementia. Wealth was log transformed and used as continuous and binary (≥median,

Published
2024
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14. Strategies to promote scholarship among academic hospitalists.

Author

Jha, Pinky, Bhandari, Sanjay, and Slawski, Barbara

Abstract

Academic hospitalists play an integral role in the day-to-day care of hospitalized patients, education and research. They are well-positioned to engage in scholarly and research activities and inform clinical practice. Hospital medicine also offers a compelling career path for those seeking to maintain a broad clinical focus while also pursuing opportunities in quality improvement (QI), clinical research, and medical education (MedEd) projects. Participation in these endeavors not only foster scholarly growth but also enhances career satisfaction for hospitalists. Therefore, there is a need to explore and implement feasible strategies to equip hospitalists with the knowledge and resources necessary to generate scholarship and promote academic growth within the field. [ABSTRACT FROM AUTHOR]

Published
2024
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37. The impact of learning‐curve‐experience on transcatheter aortic valve replacement outcomes: Insights from the United Kingdom and Ireland all‐comers second‐generation ACURATE neo™ transcatheter aortic heart valve registry.

Author

Gunarathne, Ashan, Tan, Joon, Varcoe, Richard, Bhandari, Sanjay, Faour, Amir, Tanseco, Kristoffer, Mylotte, Darren, Mitchell, Andrew, Armario, Xavier, Owens, Colum, Spence, Mark, Cunnington, Michael, Casserly, Ivan, Kovac, Jan, Hildick‐Smith, David, and Baig, Kamran

Published
2022
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43. Waving, not drowning.

Author

Bhandari, Sanjay and Rees, Matthew

Subjects
Discovery (Law) -- Laws, regulations and rules, Electronic records -- Access control, Computer files -- Access control, Government regulation
Published
2005

45. Recent trends in cyclic vomiting syndrome‐associated hospitalisations with liberalisation of cannabis use in the state of Colorado.

Author

Bhandari, Sanjay, Jha, Pinky, Lisdahl, Krista M., Hillard, Cecilia J., and Venkatesan, Thangam

Subjects
*CANNABIS (Genus), *HOSPITAL care, *HOSPITAL admission & discharge, *PATIENTS, *SYNDROMES, *VOMITING, *LOGISTIC regression analysis
Abstract

Background: Currently, 33 states in the United States along with the District of Columbia have legalised cannabis in some forms. There is a paucity of data on the impact of legalisation of cannabis use on hospitalisations due to cyclic vomiting syndrome (CVS). Aim: To study the trends in CVS‐related hospitalisations and cannabis use in CVS in relation to legalisation of recreational cannabis use in Colorado. Methods: All hospital admissions in Colorado between 2010 and 2014 with the diagnosis of CVS were identified using the Colorado State Inpatient Database. Five‐year trends in CVS‐related hospitalisations along with the cannabis use were analysed. Multivariate logistic regression analysis was performed to determine predictors of cannabis use in CVS. Results: There was a significant increase in CVS‐related hospitalisations by 46% from 806 in 2010 to 1180 in 2014 when CVS was included as all‐listed diagnoses (P < 0.001). The overall prevalence of cannabis use in CVS (13% with CVS as primary diagnosis and 17% with CVS as all‐listed diagnoses) was much higher than non‐CVS‐related hospitalisations (1.7%) (P < 0.001 for both comparisons). Cannabis use increased dramatically in both CVS and non‐CVS‐related hospitalisations following legalisation of cannabis for recreational use in 2012. Conclusion: Our study shows a significant increase in CVS‐related hospitalisations concomitant with an increase in cannabis use with its liberalisation in Colorado. Future studies on the relationship between cannabis use and hyperemesis are warranted, especially with its ongoing legalisation in the United States. [ABSTRACT FROM AUTHOR]

Published
2019
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47. Temporomandibular joint (TMJ) dislocation after LMA insertion

Author

Bhandari, Sanjay, Bhanu, Sarkar, Manju, and Dewoolkar, L.V.

Subjects
Temporomandibular joint disorders -- Case studies, Temporomandibular joint disorders -- Causes of, Respirators -- Complications and side effects, Health
Abstract

Table of Contents Abstract Introduction Case Discussion References Abstract We report a case of temporomandibular joint dislocation during LMA insertion under general anaesthesia, in a 30-years old female patient who [...]

Published
2008

48. Endobronchial intubation: a method for confirmation of endotracheal intubation in infants

Author

Thota, Raghu S., Bhandari, Sanjay, Jedge, Prashant, Gaitonde, Kalpesh, and Dewoolkar, L.V.

Subjects
Anesthesia -- Methods, Trachea -- Properties, Bronchi -- Properties, Infants -- Health aspects, Chest -- Intubation, Chest -- Methods, Health
Abstract

Table of Contents Abstract Introduction Case report Discussion References Abstract Tracheal intubation to secure a patients airway is a fundamental skill in anaesthesia practice. Confirmation of endotracheal intubation in neonates [...]

Published
2007

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