20 results on '"Best, Kate E."'
Search Results
2. Projected number of children with isolated spina bifida or down syndrome in England and Wales by 2020
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Best, Kate E., Glinianaia, Svetlana V., Lingam, Raghu, Morris, Joan K., and Rankin, Judith
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- 2018
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3. Maternal obesity classes, preterm and post-term birth: a retrospective analysis of 479,864 births in England
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Slack, Emma, Best, Kate E., Rankin, Judith, and Heslehurst, Nicola
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- 2019
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4. The Tyneside Pegboard Test: development, validation, and observations in unilateral cerebral palsy
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Basu, Anna P, Kirkpatrick, Emma V, Wright, Blythe, Pearse, Janice E, Best, Kate E, and Eyre, Janet A
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- 2018
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5. Survival adjusted cancer risks attributable to radiation exposure from cardiac catheterisations in children
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Harbron, Richard W, Chapple, Claire-Louise, OʼSullivan, John J, Best, Kate E, Berrington de González, Amy, and Pearce, Mark S
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- 2017
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6. Epidemiology of congenital diaphragmatic hernia in Europe: a register-based study
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McGivern, Mark R, Best, Kate E, Rankin, Judith, Wellesley, Diana, Greenlees, Ruth, Addor, Marie-Claude, Arriola, Larraitz, de Walle, Hermien, Barisic, Ingeborg, Beres, Judit, Bianchi, Fabrizio, Calzolari, Elisa, Doray, Berenice, Draper, Elizabeth S, Garne, Ester, Gatt, Miriam, Haeusler, Martin, Khoshnood, Babak, Klungsoyr, Kari, Latos-Bielenska, Anna, OʼMahony, Mary, Braz, Paula, McDonnell, Bob, Mullaney, Carmel, Nelen, Vera, Queisser-Luft, Anette, Randrianaivo, Hanitra, Rissmann, Anke, Rounding, Catherine, Sipek, Antonin, Thompson, Rosie, Tucker, David, Wertelecki, Wladimir, and Martos, Carmen
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- 2015
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7. Epidemiology of small intestinal atresia in Europe: a register-based study
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Best, Kate E, Tennant, Peter W G, Addor, Marie-Claude, Bianchi, Fabrizio, Boyd, Patricia, Calzolari, Elisa, Dias, Carlos Matias, Doray, Berenice, Draper, Elizabeth, Garne, Ester, Gatt, Miriam, Greenlees, Ruth, Haeusler, Martin, Khoshnood, Babak, McDonnell, Bob, Mullaney, Carmel, Nelen, Vera, Randrianaivo, Hanitra, Rissmann, Anke, Salvador, Joaquin, Tucker, David, Wellesly, Diana, and Rankin, Judith
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- 2012
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8. Long-term survival of children born with congenital anomalies: A systematic review and meta-analysis of population-based studies.
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Glinianaia, Svetlana V., Morris, Joan K., Best, Kate E., Santoro, Michele, Coi, Alessio, Armaroli, Annarita, and Rankin, Judith
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CONGENITAL disorders ,HUMAN abnormalities ,CONGENITAL heart disease ,BILIARY atresia ,META-analysis ,PUBLICATION bias - Abstract
Background: Following a reduction in global child mortality due to communicable diseases, the relative contribution of congenital anomalies to child mortality is increasing. Although infant survival of children born with congenital anomalies has improved for many anomaly types in recent decades, there is less evidence on survival beyond infancy. We aimed to systematically review, summarise, and quantify the existing population-based data on long-term survival of individuals born with specific major congenital anomalies and examine the factors associated with survival.Methods and Findings: Seven electronic databases (Medline, Embase, Scopus, PsycINFO, CINAHL, ProQuest Natural, and Biological Science Collections), reference lists, and citations of the included articles for studies published 1 January 1995 to 30 April 2020 were searched. Screening for eligibility, data extraction, and quality appraisal were performed in duplicate. We included original population-based studies that reported long-term survival (beyond 1 year of life) of children born with a major congenital anomaly with the follow-up starting from birth that were published in the English language as peer-reviewed papers. Studies on congenital heart defects (CHDs) were excluded because of a recent systematic review of population-based studies of CHD survival. Meta-analysis was performed to pool survival estimates, accounting for trends over time. Of 10,888 identified articles, 55 (n = 367,801 live births) met the inclusion criteria and were summarised narratively, 41 studies (n = 54,676) investigating eight congenital anomaly types (spina bifida [n = 7,422], encephalocele [n = 1,562], oesophageal atresia [n = 6,303], biliary atresia [n = 3,877], diaphragmatic hernia [n = 6,176], gastroschisis [n = 4,845], Down syndrome by presence of CHD [n = 22,317], and trisomy 18 [n = 2,174]) were included in the meta-analysis. These studies covered birth years from 1970 to 2015. Survival for children with spina bifida, oesophageal atresia, biliary atresia, diaphragmatic hernia, gastroschisis, and Down syndrome with an associated CHD has significantly improved over time, with the pooled odds ratios (ORs) of surviving per 10-year increase in birth year being OR = 1.34 (95% confidence interval [95% CI] 1.24-1.46), OR = 1.50 (95% CI 1.38-1.62), OR = 1.62 (95% CI 1.28-2.05), OR = 1.57 (95% CI 1.37-1.81), OR = 1.24 (95% CI 1.02-1.5), and OR = 1.99 (95% CI 1.67-2.37), respectively (p < 0.001 for all, except for gastroschisis [p = 0.029]). There was no observed improvement for children with encephalocele (OR = 0.98, 95% CI 0.95-1.01, p = 0.19) and children with biliary atresia surviving with native liver (OR = 0.96, 95% CI 0.88-1.03, p = 0.26). The presence of additional structural anomalies, low birth weight, and earlier year of birth were the most commonly reported predictors of reduced survival for any congenital anomaly type. The main limitation of the meta-analysis was the small number of studies and the small size of the cohorts, which limited the predictive capabilities of the models resulting in wide confidence intervals.Conclusions: This systematic review and meta-analysis summarises estimates of long-term survival associated with major congenital anomalies. We report a significant improvement in survival of children with specific congenital anomalies over the last few decades and predict survival estimates up to 20 years of age for those born in 2020. This information is important for the planning and delivery of specialised medical, social, and education services and for counselling affected families. This trial was registered on the PROSPERO database (CRD42017074675). [ABSTRACT FROM AUTHOR]- Published
- 2020
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9. Multilevel analyses of related public health indicators: The European Surveillance of Congenital Anomalies (EUROCAT) Public Health Indicators.
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Best, Kate E., Rankin, Judith, Dolk, Helen, Loane, Maria, Haeusler, Martin, Nelen, Vera, Verellen‐Dumoulin, Christine, Garne, Ester, Sayers, Gerardine, Mullaney, Carmel, O'Mahony, Mary T., Gatt, Miriam, De Walle, Hermien, Klungsoyr, Kari, Carolla, Olatz Mokoroa, Cavero‐Carbonell, Clara, Kurinczuk, Jennifer J., Draper, Elizabeth S., Tucker, David, and Wellesley, Diana
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PUBLIC health , *PERINATAL death , *POISSON regression , *CONGENITAL disorders , *HUMAN abnormalities - Abstract
Background: Public health organisations use public health indicators to guide health policy. Joint analysis of multiple public health indicators can provide a more comprehensive understanding of what they are intended to evaluate.Objective: To analyse variaitons in the prevalence of congenital anomaly-related perinatal mortality attributable to termination of pregnancy for foetal anomaly (TOPFA) and prenatal diagnosis of congenital anomaly prevalence.Methods: We included 55 363 cases of congenital anomalies notified to 18 EUROCAT registers in 10 countries during 2008-12. Incidence rate ratios (IRR) representing the risk of congenital anomaly-related perinatal mortality according to TOPFA and prenatal diagnosis prevalence were estimated using multilevel Poisson regression with country as a random effect. Between-country variation in congenital anomaly-related perinatal mortality was measured using random effects and compared between the null and adjusted models to estimate the percentage of variation in congenital anomaly-related perinatal mortality accounted for by TOPFA and prenatal diagnosis.Results: The risk of congenital anomaly-related perinatal mortality decreased as TOPFA and prenatal diagnosis prevalence increased (IRR 0.79, 95% confidence interval [CI] 0.72, 0.86; and IRR 0.88, 95% CI 0.79, 0.97). Modelling TOPFA and prenatal diagnosis together, the association between congenital anomaly-related perinatal mortality and TOPFA prevalence became stronger (RR 0.70, 95% CI 0.61, 0.81). The prevalence of TOPFA and prenatal diagnosis accounted for 75.5% and 37.7% of the between-country variation in perinatal mortality, respectively.Conclusion: We demonstrated an approach for analysing inter-linked public health indicators. In this example, as TOPFA and prenatal diagnosis of congenital anomaly prevalence decreased, the risk of congenital anomaly-related perinatal mortality increased. Much of the between-country variation in congenital anomaly-related perinatal mortality was accounted for by TOPFA, with a smaller proportion accounted for by prenatal diagnosis. [ABSTRACT FROM AUTHOR]- Published
- 2020
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10. Assessing the deprivation gap in stillbirths and neonatal deaths by cause of death: a national population-based study.
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Best, Kate E., Seaton, Sarah E., Draper, Elizabeth S., Field, David J., Kurinczuk, Jennifer J., Manktelow, Bradley N., and Smith, Lucy K.
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STILLBIRTH ,CAUSES of death ,SUDDEN infant death syndrome - Abstract
Objective: To investigate socioeconomic inequalities in cause-specific stillbirth and neonatal mortality to identify key areas of focus for future intervention strategies to achieve government ambitions to reduce mortality rates.Design: Retrospective cohort study.Setting: England, Wales, Scotland and the UK Crown Dependencies.Participants: All singleton births between 1 January 2014 and 31 December 2015 at ≥24 weeks' gestation.Main Outcome Measure: Cause-specific stillbirth or neonatal death (0-27 days after birth) per 10 000 births by deprivation quintile.Results: Data on 5694 stillbirths (38.1 per 10 000 total births) and 2368 neonatal deaths (15.9 per 10 000 live births) were obtained from Mothers and Babies: Reducing Risk through Audits and Confidential Enquiries across the UK (MBRRACE-UK). Women from the most deprived areas were 1.68 (95% CI 1.56 to 1.81) times more likely to experience a stillbirth and 1.67 (95% CI 1.48 to 1.87) times more likely to experience a neonatal death than those from the least deprived areas, equating to an excess of 690 stillbirths and 231 neonatal deaths per year associated with deprivation. Small for gestational age (SGA) unexplained antepartum stillbirth was the greatest contributor to excess stillbirths accounting for 33% of the deprivation gap in stillbirths. Congenital anomalies accounted for the majority (59%) of the deprivation gap in neonatal deaths, followed by preterm birth not SGA (24-27 weeks, 27%).Conclusions: Cause-specific mortality rates at a national level allow identification of key areas of focus for future intervention strategies to reduce mortality. Despite a reduction in the deprivation gap for stillbirths and neonatal deaths, public health interventions should primarily focus on socioeconomic determinants of SGA stillbirth and congenital anomalies. [ABSTRACT FROM AUTHOR]- Published
- 2019
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11. Socio-economic inequalities in mortality in children with congenital heart disease: A systematic review and meta-analysis.
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Best, Kate E., Vieira, Rute, Glinianaia, Svetlana V., and Rankin, Judith
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POVERTY areas , *CONGENITAL heart disease , *META-analysis , *RESEARCH funding , *SYSTEMATIC reviews , *SOCIOECONOMIC factors , *HEALTH equity - Abstract
Background: The impact of socio-economic status (SES) on congenital heart disease (CHD)-related mortality in children is not well established.Objectives: We aimed to systematically review and appraise the existing evidence on the association between SES (including poverty, parental education, health insurance, and income) and mortality among children with CHD.Data Sources: Seven electronic databases (Medline, Embase, Scopus, PsycINFO, CINAHL, ProQuest Natural, and Biological Science Collections), reference lists, citations, and key journals were searched.Study Selection and Data Extraction: We included articles reporting original research on the association between SES and mortality in children with CHD if they were full papers published in the English language and regardless of (a) timing of mortality; (b) individual or area-based measures of SES; (c) CHD subtype; (d) age at ascertainment; (e) study period examined. Screening for eligibility, data extraction, and quality appraisal were performed in duplicate.Synthesis: Meta-analyses were performed to estimate pooled ORs for in-hospital mortality according to health insurance status.Results: Of 1388 identified articles, 28 met the inclusion criteria. Increased area-based poverty was associated with increased odds/risk of postoperative (n = 1), neonatal (n = 1), post-discharge (n = 1), infant (n = 1), and long-term mortality (n = 2). Higher parental education was associated with decreased odds/risk of neonatal (n = 1) and infant mortality (n = 5), but not with long-term mortality (n = 1). A meta-analysis of four US articles showed increased unadjusted odds of in-hospital mortality in those with government/public versus private health insurance (OR 1.40, 95% CI 1.24, 1.56). The association between area-based income and CHD-related mortality was conflicting, with three of eight articles reporting significant associations.Conclusion: This systematic review provides evidence that children of lower SES are at increased risk of CHD-related mortality. As these children are over-represented in the CHD population, interventions targeting socio-economic inequalities could have a large impact on improving CHD survival. [ABSTRACT FROM AUTHOR]- Published
- 2019
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12. Predicting the prevalence of cerebral palsy by severity level in children aged 3 to 15 years across England and Wales by 2020.
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Glinianaia, Svetlana V, Best, Kate E, Lingam, Raghu, and Rankin, Judith
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PEOPLE with cerebral palsy , *CEREBRAL palsy , *CHILDREN'S health , *JUVENILE diseases , *HEALTH planning , *DIAGNOSIS , *RESEARCH funding , *SURVIVAL analysis (Biometry) , *DISEASE prevalence , *SEVERITY of illness index - Abstract
Aim: To estimate the number of children living with cerebral palsy (CP) in England and Wales in 2013 by severity, and to extrapolate this figure to 2020.Method: Data from the North of England Collaborative Cerebral Palsy Survey for births during the period 1991 to 2000 were restricted to individuals aged at or above 3 years to estimate the prevalence of CP and to calculate 15-year survival by severity according to the number of severe impairments and lifestyle assessment score. The number of 3- to 15-year-olds with CP of different severity in England and Wales was estimated in 2013 and 2019 using actual and nationally projected births.Results: Cumulative survival estimates up to the age of 16 years in children with CP differ significantly by severity, ranging between 97 per cent and 100 per cent for children with non-severe CP, and between 64 per cent and 67 per cent for those with the most severe CP. By the end of 2013, the estimated number of children aged 3 to 15 years living with CP in England and Wales will be about 20 500 rising to approximately 22 100 by 2020, a 7.5 per cent increase.Interpretation: Owing to an increasing population, the number of children living with CP in England and Wales will increase by 2020. This will have significant implications for health and social care service planning. [ABSTRACT FROM AUTHOR]- Published
- 2017
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13. Survival, by Birth Weight and Gestational Age, in Individuals With Congenital Heart Disease: A Population-Based Study.
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Best, Kate E., Tennant, Peter W. G., and Rankin, Judith
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- 2017
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14. Is advanced maternal age a risk factor for congenital heart disease?
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Best, Kate E. and Rankin, Judith
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Background Studies have reported that advanced maternal age is a risk factor for congenital heart disease (CHD), but none of these have been performed in the United Kingdom. Currently, women in the United Kingdom are not referred for specialist fetal echocardiography based on maternal age alone. The aim of this study is to examine the association between maternal age at delivery and CHD prevalence in the North of England. Methods Singleton cases of CHD notified to the Northern Congenital Abnormality Survey and born between January 1, 1998, to December 31, 2013, were included. Cases with chromosomal anomalies were excluded. The relative risk (RR) of CHD according to maternal age at delivery was estimated using Poisson regression. Results There were 4024 singleton cases of nonchromosomal CHD, giving a prevalence of 8.1 (95% confidence interval [CI], 7.8-8.3) per 1000 live and stillbirths. There was no association between maternal age at delivery and CHD prevalence ( p = 0.97), with no evidence of an increased risk of CHD in mothers aged ≥35 compared to aged 25 to 29 (RR = 0.99; 95% CI, 0.89-1.09). There were no significant associations between maternal age at delivery and severity III CHD ( p = 0.84), severity II CHD ( p = 0.74), or severity I CHD ( p = 0.66), although there was a slight increased risk of severity I CHD in mothers aged ≥35 (RR = 1.27; 95% CI, 0.83-1.95). Conclusion We found little evidence that advanced maternal age is a risk factor for CHD. There is no evidence that women in the United Kingdom should be referred for specialist prenatal cardiac screening based on their age. Birth Defects Research (Part A) 106:461-467, 2016. © 2016 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]
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- 2016
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15. Register based study of anorectal anomalies over 26 years: Associated anomalies, prevalence, and trends.
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Godse, Alok S., Best, Kate E., Lawson, Anne, Rosby, Lucy, and Rankin, Judith
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BACKGROUND Anorectal anomalies are atresias or stenoses of the anal canal and rectum with or without fistulous connections with the bladder, urethra, perineum, or vestibule. The aim of this study was to describe the epidemiology of anorectal anomalies, including associated anomalies, prevalence, and temporal trends. METHODS Anorectal anomalies occurring in late miscarriages (>20 gestation weeks), terminations of pregnancy for fetal anomaly (any gestation), stillbirths (≥24 gestation weeks) and live births, delivered from 1985 to 2010, notified to the Northern Congenital Abnormality Survey (NorCAS) were included in this population-based case series. RESULTS There were 278 cases among 892,194 live births. Twenty (7.2%) cases occurred in twin pregnancies and 24 (8.7%) with chromosomal anomalies/genetic syndromes were excluded. There were 234 cases (total prevalence = 2.7, 95% confidence interval [CI]: 2.4, 3.1 per 10,000 live and stillbirths). There was no evidence of a trend in prevalence over time (Chi
2 test for trend: p = 0.789). There was a male predominance (70.9%). Of the 234 cases, 167 (71.4%) were live born, two (0.9%) were late miscarriages, seven (3.0%) were stillbirths, and 58 (24.8%) were terminations of pregnancy for fetal anomaly. There was no significant association with maternal age at delivery ( p = 0.095). 7.2% of isolated cases (cases with no other congenital anomalies) were diagnosed prenatally. CONCLUSION The prevalence of anorectal anomalies in this study is comparable to other case series. There was no evidence of a temporal increase in prevalence. We confirmed a male predominance of anorectal anomalies and no significant association with maternal age. Birth Defects Research (Part A) 103:597-602, 2015. © 2015 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]- Published
- 2015
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16. Hirschsprung's Disease Prevalence in Europe: A Register Based Study.
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Best, Kate E., Addor, Marie‐Claude, Arriola, Larraitz, Balku, Eszter, Barisic, Ingeborg, Bianchi, Fabrizio, Calzolari, Elisa, Curran, Rhonda, Doray, Berenice, Draper, Elizabeth, Garne, Ester, Gatt, Miriam, Haeusler, Martin, Bergman, Jorieke, Khoshnood, Babak, Klungsoyr, Kari, Martos, Carmen, Materna‐Kiryluk, Anna, Matias Dias, Carlos, and McDonnell, Bob
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Background: Hirschsprung's disease is a congenital gut motility disorder, characterised by the absence of the enteric ganglion cells along the distal gut. The aim of this study was to describe the epidemiology of Hirschsprung's disease, including additional congenital anomalies, total prevalence, trends, and association with maternal age. Methods: Cases of Hirschsprung's disease delivered during 1980 to 2009 notified to 31 European Surveillance of Congenital Anomaly registers formed the population-based case-series. Prevalence rates and 95% confidence intervals were calculated as the number of cases per 10,000 births. Multilevel Poisson regression was performed to investigate trends in prevalence, geographical variation and the association with maternal age. Results: There were 1,322 cases of Hirschsprung's disease among 12,146,210 births. The total prevalence was 1.09 (95% confidence interval, 1.03-1.15) per 10,000 births and there was a small but significant increase in prevalence over time (relative risk=1.01; 95% credible interval, 1.00-1.02; p=0.004). There was evidence of geographical heterogeneity in prevalence (p<0.001). Excluding 146 (11.0%) cases with chromosomal anomalies or genetic syndromes, there were 1,176 cases (prevalence=0.97; 95% confidence interval, 0.91-1.03 per 10,000 births), of which 137 (11.6%) had major structural anomalies. There was no evidence of a significant increased risk of Hirschsprung's disease in cases born to women aged ≥35 years compared with those aged 25 to 29 (relative risk=1.09; 95% credible interval, 0.91-1.31; p=0.355). Conclusion: This large population-based study found evidence of a small increasing trend in Hirschsprung's disease and differences in prevalence by geographic location. There was also no evidence of an association with maternal age. [ABSTRACT FROM AUTHOR]
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- 2014
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17. Hirschsprung's disease in the North of England: Prevalence, associated anomalies, and survival.
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Best, Kate E., Glinianaia, Svetlana V., Bythell, Mary, and Rankin, Judith
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INTRODUCTION Hirschsprung's disease is the commonest congenital gut motility disorder, characterized by the absence of the enteric ganglion cells along the distal gut, which causes intestinal obstruction. Few publications report its epidemiology and temporal trends. METHODS Cases of Hirschsprung's disease delivered during 1990 to 2008 in the North of England reported to the Northern Congenital Abnormality Survey (NorCAS) formed this population-based case series. RESULTS Of 612,916 live births, 105 cases were reported to NorCAS. After excluding one diabetic and four multiple pregnancies, the live birth prevalence was 1.63 (95% confidence interval [CI], 1.33-1.98) per 10,000 live births. There was a significant temporal increase in the prevalence of Hirschsprung's disease ( p = 0.020), from 1.26 (95% CI, 0.80-1.89) in 1990 to 1994 to 2.29 (95% CI, 1.53-3.29) in 2005 to 2008. The ratio of male to female cases was 2:1. Ten (10.0%) cases occurred with Down syndrome, one with Smith-Lemli-Opitz Syndrome, and six (6.0%) with associated structural anomalies. The remaining 83 (83.0%) cases were isolated. All cases were live born, but nine (9.0%) died in the first year of life. Hirschsprung's disease was not prenatally suspected in any case. Half the cases were diagnosed within 5 days postpartum, but time of diagnosis ranged from birth to 5 years of age. CONCLUSION This study confirmed a male predominance and an association with Down syndrome, but also founda temporal increase in Hirschsprung's disease prevalence. No cases were suspected prenatally, but half were diagnosed within 5 days of life. Birth Defects Research (Part A), 2012. © 2012 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]
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- 2012
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18. Diet, Physical Activity and Gestational Weight Gain Patterns among Pregnant Women Living with Obesity in the North East of England: The GLOWING Pilot Trial.
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Heslehurst, Nicola, Flynn, Angela C., Ngongalah, Lem, McParlin, Catherine, Dalrymple, Kathryn V., Best, Kate E., Rankin, Judith, and McColl, Elaine
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Maternal diet, physical activity (PA) behaviours, and gestational weight gain (GWG) are important for optimum health of women and their babies. This secondary analysis of the GLOWING pilot cluster trial explored these among women living with obesity in high deprivation. Pregnant women completed food frequency, PA and psychosocial questionnaires. Weights were retrieved from medical records and measured during routine appointments with midwives. Descriptive and regression analyses were stratified by obesity class. A total of 163 women were recruited; 54.0% had class 1 obesity, 25.8% class 2, 20.2% class 3, and 76.1% lived in the two most deprived quintiles. Women had suboptimal dietary intake, particularly for oily fish, fruit and vegetables. PA was predominantly light intensity, from household, care and occupational activities. Most women gained weight outside of Institute of Medicine (IOM) guideline recommendations (87.8%); women in class 3 obesity were most likely to have inadequate GWG below IOM recommendations (58.3%, p < 0.01) and reduced odds of excessive GWG compared with class 1 (AOR 0.13, 95% 0.04–0.45). Deprived women with obesity have a double inequality as both increase pregnancy risks. This population requires support to meet guideline recommendations for diet, PA and GWG. Further research exploring obesity classes would inform policies and care to achieve the best pregnancy outcomes. [ABSTRACT FROM AUTHOR]
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- 2021
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19. Long-Term Survival of Individuals Born With Congenital Heart Disease: A Systematic Review and Meta-Analysis.
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Best, Kate E. and Rankin, Judith
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- 2016
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20. The Improved Prognosis of Hypoplastic Left Heart: A Population-Based Register Study of 343 Cases in England and Wales.
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Best KE, Miller N, Draper E, Tucker D, Luyt K, and Rankin J
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Background: Hypoplastic Left Heart Syndrome (HLHS) is a severe congenital heart defect (CHD) characterised by the underdevelopment of the left side of the heart with varying levels of hypoplasia of the left atrium, mitral valve, left ventricle, aortic valve and aortic arch. In the UK, age 12 survival for cases born between 1991 and 1993 was 21%. UK survival estimates corresponding to cases born between 2000 and 2015 were improved at 56%, but survival was examined up to age five only. Contemporary long-term survival estimates play a crucial role in counselling parents following diagnosis. The aim of this study was to report survival estimates up to age 15 for children born with HLHS or hypoplastic left ventricle with additional CHD in England and Wales between 1998 and 2012. Methods: Cases of HLHS notified to four congenital anomaly registers in England and Wales during 1998-2012, matched to Office for National Statistics mortality information, were included. Kaplan-Meier survival estimates to age 15 were reported. Cox regression models were fitted to examine risk factors for mortality. Results: There were 244 cases of HLHS and 99 cases of hypoplastic left ventricle co-occurring with other CHD, with traced survival status. Kaplan-Meier survival estimates for HLHS were 84.4% at age 1 week, 76.2% at 1 month, 63.5% at age 1 year, 58.6% at age 5 years, 54.6% at age 10 years, and 32.6% to age 15 years. The Kaplan-Meier survival estimates for cases of hypoplastic left ventricle co-occurring with additional CHD were 90.9% at age 1 week, 84.9% at 1 month, 73.7% at age 1 year, 67.7% to age 5 years, 59.2% to age 10 years, and 40.3% to age 15 years. Preterm birth ( p = 0.007), low birth weight ( p = 0.005), and female sex ( p = 0.01) were associated with mortality. Conclusions: We have shown that prognosis associated with HLHS in the twenty first century exceeds that of many previous population-based studies, likely due to improvements in intensive care technologies and advances in surgical techniques over the last few decades., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling Editor declared a past co-authorship with the authors KB, JR., (Copyright © 2021 Best, Miller, Draper, Tucker, Luyt and Rankin.)
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- 2021
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