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3. Probing spin-dependent dark matter interactions with 6Li: CRESST Collaboration

Author

Angloher, G., Benato, G., Bento, A., Bertoldo, E., Bertolini, A., Breier, R., Bucci, C., Canonica, L., D’Addabbo, A., Di Lorenzo, S., Einfalt, L., Erb, A., Feilitzsch, F. v., Ferreiro Iachellini, N., Fichtinger, S., Fuchs, D., Fuss, A., Garai, A., Ghete, V. M., Gorla, P., Gupta, S., Hauff, D., Ješkovský, M., Jochum, J., Kaznacheeva, M., Kinast, A., Kluck, H., Kraus, H., Langenkämper, A., Mancuso, M., Marini, L., Mokina, V., Nilima, A., Olmi, M., Ortmann, T., Pagliarone, C., Palušová, V., Pattavina, L., Petricca, F., Potzel, W., Povinec, P., Pröbst, F., Pucci, F., Reindl , F., Rothe, J., Schäffner, K., Schieck, J., Schmiedmayer, D., Schönert, S., Schwertner, C., Stahlberg, M., Stodolsky, L., Strandhagen, C., Strauss, R., Usherov, I., Wagner, F., Willers, M., and Zema, V.

Published
2022
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8. Cryogenic characterization of a LiAlO2 crystal and new results on spin-dependent dark matter interactions with ordinary matter: CRESST Collaboration

Author

Abdelhameed, A. H., Angloher, G., Bauer, P., Bento, A., Bertoldo, E., Breier, R., Bucci, C., Canonica, L., D’Addabbo, A., Di Lorenzo, S., Erb, A., Feilitzsch, F. V., Iachellini, N. Ferreiro, Fichtinger, S., Fuchs, D., Fuss, A., Ghete, V. M., Garai, A., Gorla, P., Hauff, D., Ješkovský, M., Jochum, J., Kaizer, J., Kaznacheeva, M., Kinast, A., Kluck, H., Kraus, H., Langenkämper, A., Mancuso, M., Mokina, V., Mondragon, E., Olmi, M., Ortmann, T., Pagliarone, C., Palušová, V., Pattavina, L., Petricca, F., Potzel, W., Povinec, P., Pröbst, F., Reindl, F., Rothe, J., Schäffner, K., Schieck, J., Schipperges, V., Schmiedmayer, D., Schönert, S., Schwertner, C., Stahlberg, M., Stodolsky, L., Strandhagen, C., Strauss, R., Usherov, I., Wagner, F., Willers, M., Zema, V., Zeman, J., Brützam, M., and Ganschow, S.

Published
2020
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9. New limits on the resonant absorption of solar axions obtained with a 169Tm-containing cryogenic detector

Author

Abdelhameed, A. H., Bakhlanov, S. V., Bauer, P., Bento, A., Bertoldo, E., Canonica, L., Derbin, A. V., Drachnev, I. S., Iachellini, N. Ferreiro, Fuchs, D., Hauff, D., Laubenstein, M., Lis, D. A., Lomskaya, I. S., Mancuso, M., Muratova, V. N., Nagorny, S., Nisi, S., Petricca, F., Proebst, F., Rothe, J., Ryabchenkov, V. V., Sarkisov, S. E., Semenov, D. A., Subbotin, K. A., Trushin, M. V., Unzhakov, E. V., and Zharikov, E. V.

Published
2020
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10. Erratum to: Geant4-based electromagnetic background model for the CRESST dark matter experiment

Author

Abdelhameed, A. H., Angloher, G., Bauer, P., Bento, A., Bertoldo, E., Breier, R., Bucci, C., Canonica, L., D’Addabbo, A., Lorenzo, S. Di, Erb, A., Feilitzsch, F. v., Iachellini, N. Ferreiro, Fichtinger, S., Fuss, A., Gorla, P., Hauff, D., Jes̆kovský, M., Jochum, J., Kaizer, J., Kinast, A., Kluck, H., Kraus, H., Langenkämper, A., Mancuso, M., Mokina, V., Mondragón, E., Olmi, M., Ortmann, T., Pagliarone, C., Palus̆ová, V., Pattavina, L., Petricca, F., Potzel, W., Povinec, P., Pröbst, F., Reindl, F., Rothe, J., Schäffner, K., Schieck, J., Schipperges, V., Schmiedmayer, D., Schönert, S., Schwertner, C., Stahlberg, M., Stodolsky, L., Strandhagen, C., Strauss, R., Türkoğlu, C., Usherov, I., Willers, M., Zema, V., and Zeman, J.

Published
2019
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12. Geant4-based electromagnetic background model for the CRESST dark matter experiment

Author

Abdelhameed, A. H., Angloher, G., Bauer, P., Bento, A., Bertoldo, E., Breier, R., Bucci, C., Canonica, L., D’Addabbo, A., Lorenzo, S. Di, Erb, A., Feilitzsch, F. v., Iachellini, N. Ferreiro, Fichtinger, S., Fuss, A., Gorla, P., Hauff, D., Jes̆kovský, M., Jochum, J., Kaizer, J., Kinast, A., Kluck, H., Kraus, H., Langenkämper, A., Mancuso, M., Mokina, V., Mondragón, E., Olmi, M., Ortmann, T., Pagliarone, C., Palus̆ová, V., Pattavina, L., Petricca, F., Potzel, W., Povinec, P., Pröbst, F., Reindl, F., Rothe, J., Schäffner, K., Schieck, J., Schipperges, V., Schmiedmayer, D., Schönert, S., Schwertner, C., Stahlberg, M., Stodolsky, L., Strandhagen, C., Strauss, R., Türkoğlu, C., Usherov, I., Willers, M., Zema, V., and Zeman, J.

Published
2019
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13. First results on sub-GeV spin-dependent dark matter interactions with 7Li

Author

Abdelhameed, A. H., Angloher, G., Bauer, P., Bento, A., Bertoldo, E., Bucci, C., Canonica, L., D’Addabbo, A., Defay, X., Di Lorenzo, S., Erb, A., Feilitzsch, F. v., Iachellini, N. Ferreiro, Fichtinger, S., Fuss, A., Gorla, P., Hauff, D., Jochum, J., Kinast, A., Kluck, H., Kraus, H., Langenkämper, A., Mancuso, M., Mokina, V., Mondragon, E., Münster, A., Olmi, M., Ortmann, T., Pagliarone, C., Pattavina, L., Petricca, F., Potzel, W., Pröbst, F., Reindl, F., Rothe, J., Schäffner, K., Schieck, J., Schipperges, V., Schmiedmayer, D., Schönert, S., Schwertner, C., Stahlberg, M., Stodolsky, L., Strandhagen, C., Strauss, R., Türkoğlu, C., Usherov, I., Willers, M., Zema, V., (THE CRESST Collaboration), Chapellier, M., Giuliani, A., Nones, C., Poda, D. V., Shlegel, V. N., Velázquez, M., and Zolotarova, A. S.

Published
2019
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14. DarkSide-20k: A 20 tonne two-phase LAr TPC for direct dark matter detection at LNGS

Author

Aalseth, C. E., Acerbi, F., Agnes, P., Albuquerque, I. F. M., Alexander, T., Alici, A., Alton, A. K., Antonioli, P., Arcelli, S., Ardito, R., Arnquist, I. J., Asner, D. M., Ave, M., Back, H. O., Barrado Olmedo, A. I., Batignani, G., Bertoldo, E., Bettarini, S., Bisogni, M. G., Bocci, V., Bondar, A., Bonfini, G., Bonivento, W., Bossa, M., Bottino, B., Boulay, M., Bunker, R., Bussino, S., Buzulutskov, A., Cadeddu, M., Cadoni, M., Caminata, A., Canci, N., Candela, A., Cantini, C., Caravati, M., Cariello, M., Carlini, M., Carpinelli, M., Castellani, A., Catalanotti, S., Cataudella, V., Cavalcante, P., Cavuoti, S., Cereseto, R., Chepurnov, A., Cicalò, C., Cifarelli, L., Citterio, M., Cocco, A. G., Colocci, M., Corgiolu, S., Covone, G., Crivelli, P., D’Antone, I., D’Incecco, M., D’Urso, D., Da Rocha Rolo, M. D., Daniel, M., Davini, S., de Candia, A., De Cecco, S., De Deo, M., De Filippis, G., De Guido, G., De Rosa, G., Dellacasa, G., Della Valle, M., Demontis, P., Derbin, A., Devoto, A., Di Eusanio, F., Di Pietro, G., Dionisi, C., Dolgov, A., Dormia, I., Dussoni, S., Empl, A., Fernandez Diaz, M., Ferri, A., Filip, C., Fiorillo, G., Fomenko, K., Franco, D., Froudakis, G. E., Gabriele, F., Gabrieli, A., Galbiati, C., Garcia Abia, P., Gendotti, A., Ghisi, A., Giagu, S., Giampa, P., Gibertoni, G., Giganti, C., Giorgi, M. A., Giovanetti, G. K., Gligan, M. L., Gola, A., Gorchakov, O., Goretti, A. M., Granato, F., Grassi, M., Grate, J. W., Grigoriev, G. Y., Gromov, M., Guan, M., Guerra, M. B. B., Guerzoni, M., Gulino, M., Haaland, R. K., Hallin, A., Harrop, B., Hoppe, E. W., Horikawa, S., Hosseini, B., Hughes, D., Humble, P., Hungerford, E. V., Ianni, An., Jillings, C., Johnson, T. N., Keeter, K., Kendziora, C. L., Kim, S., Koh, G., Korablev, D., Korga, G., Kubankin, A., Kuss, M., Kuźniak, M., La Commara, M., Lehnert, B., Li, X., Lissia, M., Lodi, G. U., Loer, B., Longo, G., Loverre, P., Lussana, R., Luzzi, L., Ma, Y., Machado, A. A., Machulin, I. N., Mandarano, A., Mapelli, L., Marcante, M., Margotti, A., Mari, S. M., Mariani, M., Maricic, J., Martoff, C. J., Mascia, M., Mayer, M., McDonald, A. B., Messina, A., Meyers, P. D., Milincic, R., Moggi, A., Moioli, S., Monroe, J., Monte, A., Morrocchi, M., Mount, B. J., Mu, W., Muratova, V. N., Murphy, S., Musico, P., Nania, R., Navrer Agasson, A., Nikulin, I., Nosov, V., Nozdrina, A. O., Nurakhov, N. N., Oleinik, A., Oleynikov, V., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Palmas, S., Pandola, L., Pantic, E., Paoloni, E., Paternoster, G., Pavletcov, V., Pazzona, F., Peeters, S., Pelczar, K., Pellegrini, L. A., Pelliccia, N., Perotti, F., Perruzza, R., Pesudo, V., Piemonte, C., Pilo, F., Pocar, A., Pollmann, T., Portaluppi, D., Pugachev, D. A., Qian, H., Radics, B., Raffaelli, F., Ragusa, F., Razeti, M., Razeto, A., Regazzoni, V., Regenfus, C., Reinhold, B., Renshaw, A. L., Rescigno, M., Retière, F., Riffard, Q., Rivetti, A., Rizzardini, S., Romani, A., Romero, L., Rossi, B., Rossi, N., Rubbia, A., Sablone, D., Salatino, P., Samoylov, O., Sánchez García, E., Sands, W., Sanfilippo, S., Sant, M., Santorelli, R., Savarese, C., Scapparone, E., Schlitzer, B., Scioli, G., Segreto, E., Seifert, A., Semenov, D. A., Shchagin, A., Shekhtman, L., Shemyakina, E., Sheshukov, A., Simeone, M., Singh, P. N., Skensved, P., Skorokhvatov, M. D., Smirnov, O., Sobrero, G., Sokolov, A., Sotnikov, A., Speziale, F., Stainforth, R., Stanford, C., Suffritti, G. B., Suvorov, Y., Tartaglia, R., Testera, G., Tonazzo, A., Tosi, A., Trinchese, P., Unzhakov, E. V., Vacca, A., Vázquez-Jáuregui, E., Verducci, M., Viant, T., Villa, F., Vishneva, A., Vogelaar, B., Wada, M., Wahl, J., Walding, J., Wang, H., Wang, Y., Watson, A. W., Westerdale, S., Williams, R., Wojcik, M. M., Wu, S., Xiang, X., Xiao, X., Yang, C., Ye, Z., Yllera de Llano, A., Zappa, F., Zappalà, G., Zhu, C., Zichichi, A., Zullo, M., Zullo, A., and Zuzel, G.

Published
2018
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15. Probing spin-dependent dark matter interactions with $$^6$$ <math> <msup> <mrow></mrow> <mn>6</mn> </msup> </math> Li

Author

Angloher, G., Benato, G., Bento, A., Bertoldo, E., Bertolini, A., Breier, R., Bucci, C., Canonica, L., D’Addabbo, A., Lorenzo, S., Einfalt, L., Erb, A., Feilitzsch, F., Ferreiro Iachellini, N., Fichtinger, S., Fuchs, D., Fuss, A., Garai, A., Ghete, V., Gorla, P., Gupta, S., Hauff, D., Ješkovský, M., Jochum, J., Kaznacheeva, M., Kinast, A., Kluck, H., Kraus, H., Langenkämper, A., Mancuso, M., Marini, L., Mokina, V., Nilima, A., Olmi, M., Ortmann, T., Pagliarone, C., Palušová, V., Pattavina, L., Petricca, F., Potzel, W., Povinec, P., Pröbst, F., Pucci, F., Reindl , F., Rothe, J., Schäffner, K., Schieck, J., Schmiedmayer, D., Schönert, S., Schwertner, C., Stahlberg, M., Stodolsky, L., Strandhagen, C., Strauss, R., Usherov, I., Wagner, F., Willers, M., and Zema, V.

Abstract

CRESST is one of the most prominent direct detection experiments for dark matter particles with sub-GeV/c $$^2$$ 2 mass. One of the advantages of the CRESST experiment is the possibility to include a large variety of nuclides in the target material used to probe dark matter interactions. In this work, we discuss in particular the interactions of dark matter particles with protons and neutrons of $$^{6}$$ 6 Li. This is now possible thanks to new calculations on nuclear matrix elements of this specific isotope of Li. To show the potential of using this particular nuclide for probing dark matter interactions, we used the data collected previously by a CRESST prototype based on LiAlO $$_2$$ 2 and operated in an above ground test-facility at Max-Planck-Institut für Physik in Munich, Germany. In particular, the inclusion of $$^{6}$$ 6 Li in the limit calculation drastically improves the result obtained for spin-dependent interactions with neutrons in the whole mass range. The improvement is significant, greater than two order of magnitude for dark matter masses below 1 GeV/c $$^2$$ 2 , compared to the limit previously published with the same data.

Published
2022

16. Probing spin-dependent dark matter interactions with $^6$Li

Author

Angloher, G., Benato, G., Bento, A., Bertoldo, E., Bertolini, A., Breier, R., Bucci, C., Canonica, L., D???addabbo, A., Di Lorenzo, S., Einfalt, L., Erb, A., Feilitzsch, F. v., Ferreiro Iachellini, N., Fichtinger, S., Fuchs, D., Fuss, A., Garai, A., Ghete, V. M., Gorla, P., Gupta, S., Hauff, D., Je??kovsk??, M., Jochum, J., Kaznacheeva, M., Kinast, A., Kluck, H., Kraus, H., Langenk??mper, A., Mancuso, M., Marini, L., Mokina, V., Nilima, A., Olmi, M., Ortmann, T., Pagliarone, C., Palu??ov??, V., Pattavina, L., Petricca, F., Potzel, W., Povinec, P., Pr??bst, F., Pucci, F., Reindl, F., Rothe, J., Sch??ffner, K., Schieck, J., Schmiedmayer, D., Sch??nert, S., Schwertner, C., Stahlberg, M., Stodolsky, L., Strandhagen, C., Strauss, R., Usherov, I., Wagner, F., Willers, M., and Zema, V.

Subjects
Physics - Instrumentation and Detectors, Astrophysics - Instrumentation and Methods for Astrophysics, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), Nuclear Experiment, Instrumentation and Methods for Astrophysics (astro-ph.IM)
Abstract

CRESST is one of the most prominent direct detection experiments for dark matter particles with sub-GeV/c$^2$ mass. One of the advantages of the CRESST experiment is the possibility to include a large variety of nuclides in the target material used to probe dark matter interactions. In this work, we discuss in particular the interactions of dark matter particles with protons and neutrons of $^{6}$Li. This is now possible thanks to new calculations on nuclear matrix elements of this specific isotope of Li. To show the potential of using this particular nuclide for probing dark matter interactions, we used the data collected previously by a CRESST prototype based on LiAlO$_2$ and operated in an above ground test-facility at Max-Planck-Institut f\"ur Physik in Munich, Germany. In particular, the inclusion of $^{6}$Li in the limit calculation drastically improves the result obtained for spin-dependent interactions with neutrons in the whole mass range. The improvement is significant, greater than two order of magnitude for dark matter masses below 1 GeV/c$^2$, compared to the limit previously published with the same data.

Published
2022

17. Cryogenic characterization of a $$\hbox {LiAlO}_{2}$$ <math> <msub> <mtext>LiAlO</mtext> <mn>2</mn> </msub> </math> crystal and new results on spin-dependent dark matter interactions with ordinary matter

Author

Abdelhameed, A., Angloher, G., Bauer, P., Bento, A., Bertoldo, E., Breier, R., Bucci, C., Canonica, L., D’Addabbo, A., Lorenzo, S., Erb, A., Feilitzsch, F., Iachellini, N., Fichtinger, S., Fuchs, D., Fuss, A., Ghete, V., Garai, A., Gorla, P., Hauff, D., Ješkovský, M., Jochum, J., Kaizer, J., Kaznacheeva, M., Kinast, A., Kluck, H., Kraus, H., Langenkämper, A., Mancuso, M., Mokina, V., Mondragon, E., Olmi, M., Ortmann, T., Pagliarone, C., Palušová, V., Pattavina, L., Petricca, F., Potzel, W., Povinec, P., Pröbst, F., Reindl, F., Rothe, J., Schäffner, K., Schieck, J., Schipperges, V., Schmiedmayer, D., Schönert, S., Schwertner, C., Stahlberg, M., Stodolsky, L., Strandhagen, C., Strauss, R., Usherov, I., Wagner, F., Willers, M., Zema, V., Zeman, J., Brützam, M., and Ganschow, S.

Abstract

In this work, a first cryogenic characterization of a scintillating $$\hbox {LiAlO}_{2}$$ LiAlO 2 single crystal is presented. The results achieved show that this material holds great potential as a target for direct dark matter search experiments. Three different detector modules obtained from one crystal grown at the Leibniz-Institut für Kristallzüchtung (IKZ) have been tested to study different properties at cryogenic temperatures. Firstly, two 2.8 g twin crystals were used to build different detector modules which were operated in an above-ground laboratory at the Max Planck Institute for Physics (MPP) in Munich, Germany. The first detector module was used to study the scintillation properties of $$\hbox {LiAlO}_{2}$$ LiAlO 2 at cryogenic temperatures. The second achieved an energy threshold of ( $$213.02\pm 1.48$$ 213.02 ± 1.48 ) eV which allows setting a competitive limit on the spin-dependent dark matter particle-proton scattering cross section for dark matter particle masses between $$350\,\hbox {MeV/c}^{2}$$ 350 MeV/c 2 and $$1.50\,\hbox {GeV/c}^{2}$$ 1.50 GeV/c 2 . Secondly, a detector module with a 373 g $$\hbox {LiAlO}_{2}$$ LiAlO 2 crystal as the main absorber was tested in an underground facility at the Laboratori Nazionali del Gran Sasso (LNGS): from this measurement it was possible to determine the radiopurity of the crystal and study the feasibility of using this material as a neutron flux monitor for low-background experiments.

Published
2020

18. New limits on the resonant absorption of solar axions obtained with a $$^\mathbf {169}$$ <math><msup><mrow></mrow><mn>169</mn></msup></math> Tm-containing cryogenic detector

Author

Abdelhameed, A., Bakhlanov, S., Bauer, P., Bento, A., Bertoldo, E., Canonica, L., Derbin, A., Drachnev, I., Iachellini, N., Fuchs, D., Hauff, D., Laubenstein, M., Lis, D., Lomskaya, I., Mancuso, M., Muratova, V., Nagorny, S., Nisi, S., Petricca, F., Proebst, F., Rothe, J., Ryabchenkov, V., Sarkisov, S., Semenov, D., Subbotin, K., Trushin, M., Unzhakov, E., and Zharikov, E.

Abstract

A search for resonant absorption of solar axions by $$^{169}\mathrm {Tm}$$ 169Tm nuclei was carried out. A newly developed approach involving low-background cryogenic bolometer based on $$\mathrm {Tm}_{3} \mathrm {Al}_{5} \mathrm {O}_{12}$$ Tm3Al5O12 crystal was used that allowed for significant improvement of sensitivity in comparison with previous $$^{169}\mathrm {Tm}$$ 169Tm based experiments. The measurements performed with 8.18 g crystal during 6.6 days exposure yielded the following limits on axion couplings: $$|g_{A\gamma } (g_{AN}^0 + g_{AN}^3) \le 1.44 \times 10^{-14}\,{{\mathrm{GeV}}^{-1}}$$ |gAγ(gAN0+gAN3)≤1.44×10-14GeV-1 and $$|g_{Ae} (g_{AN}^0 + g_{AN}^3) \le 2.81 \times 10^{-16}$$ |gAe(gAN0+gAN3)≤2.81×10-16 .

Published
2020

19. Cryogenic characterization of a LiAlO$_{2}$ crystal and new results on spin-dependent dark matter interactions with ordinary matter

Author

Abdelhameed, A. H., Angloher, G., Bauer, P., Bento, A., Bertoldo, E., Breier, R., Bucci, C., Canonica, L., D'Addabbo, A., Di Lorenzo, S., Erb, A., Feilitzsch, F. v., Iachellini, N. Ferreiro, Fichtinger, S., Fuchs, D., Fuss, A., Ghete, V. M., Garai, A., Gorla, P., Hauff, D., Je��kovsk��, M., Jochum, J., Kaizer, J., Kaznacheeva, M., Kinast, A., Kluck, H., Kraus, H., Langenk��mper, A., Mancuso, M., Mokina, V., Mondragon, E., Olmi, M., Ortmann, T., Pagliarone, C., Palu��ov��, V., Pattavina, L., Petricca, F., Potzel, W., Povinec, P., Pr��bst, F., Reindl, F., Rothe, J., Sch��ffner, K., Schieck, J., Schipperges, V., Schmiedmayer, D., Sch��nert, S., Schwertner, C., Stahlberg, M., Stodolsky, L., Strandhagen, C., Strauss, R., Usherov, I., Wagner, F., Willers, M., Zema, V., Zeman, J., Br��tzam, M., and Ganschow, S.

Subjects
Physics - Instrumentation and Detectors, Physics::Instrumentation and Detectors, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), Nuclear Experiment, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM)
Abstract

In this work, a first cryogenic characterization of a scintillating LiAlO$_{2}$ single crystal is presented. The results achieved show that this material holds great potential as a target for direct dark matter search experiments. Three different detector modules obtained from one crystal grown at the Leibniz-Institut f\"ur Kristallz\"uchtung (IKZ) have been tested to study different properties at cryogenic temperatures. Firstly, two 2.8 g twin crystals were used to build different detector modules which were operated in an above-ground laboratory at the Max Planck Institute for Physics (MPP) in Munich, Germany. The first detector module was used to study the scintillation properties of LiAlO$_{2}$ at cryogenic temperatures. The second achieved an energy threshold of (213.02$\pm$1.48) eV which allows setting a competitive limit on the spin-dependent dark matter particle-proton scattering cross section for dark matter particle masses between 350 MeV/c$^{2}$ and 1.50 GeV/c$^{2}$. Secondly, a detector module with a 373 g LiAlO$_{2}$ crystal as the main absorber was tested in an underground facility at the Laboratori Nazionali del Gran Sasso (LNGS): from this measurement it was possible to determine the radiopurity of the crystal and study the feasibility of using this material as a neutron flux monitor for low-background experiments.

Published
2020

20. Racial differences in systemic sclerosis disease presentation: A European Scleroderma Trials and Research group study

Author

Jaeger, Veronika K, Tikly, Mohammed, Dong, Xu, Siegert, Elise, Hachulla, Eric, Airò, Paolo, Valentini, Gabriele, Matucci Cerinic, Marco, Distler, Oliver, Cozzi, Franco, Carreira, Patricia, Allanore, Yannick, Müller-Ladner, Ulf, Ananieva, Lidia P, Balbir-Gurman, Alexandra, Distler, Jörg H W, Czirják, Laszlo, Mengtao, Li, Henes, Jörg, Jimenez, Sergio A, Smith, Vanessa, Damjanov, Nemanja, Denton, Christopher P, Delgaldo, Francesco, Saketkoo, Lesley Ann, Walker, Ulrich, A, Randone, Sb, Bannert, B, Iannone, F, Maurer, B, Jordan, S, Dobrota, R, Becker, M, Mihai, C, Becvarare, R, Tomčík, M, Bielecka, Ok, Gindzienska-Sieskiewicz, E, Karaszewska, K, Cutolo, M, Pizzorni, C, Paolino, S, Sulli, A, Ruaro, B, Alessandri, E, Riccardi, A, Giacco, V, Messitini, V, Irace, R, Kedor, C, Casteleyn, V, Hilger, J, Hoeppner, J, Rednic, S, Szabo, I, Petcu, A, Avouac, J, Camelia, F, Desbas, C, Vlachoyiannopoulos, P, Montecucco, C, Caporali, R, Cavagna, L, Stork, J, Inanc, M, Joven, Be, Novak, S, Anic, F, Varju, C, Minier, T, Chizzolini, C, Allai, D, Kucharz, Ej, Kotulska, A, Kopec-Medrek, M, Widuchowska, M, Dolnicar, As, Coleiro, B, Gabrielli, A, Manfredi, L, Benfaremo, D, Ferrarini, A, Bancel, Df, Hij, A, Lansiaux, P, Lazzaroni, Mg, Hesselstrand, R, Wuttge, D, Andréasson, R, Martinovic, D, Bozic, I, Radic, M, Braun-Moscovici, Y, Monaco, Al, Furini, F, Hunzelmann, N, Moinzadeh, P, Pellerito, R, Caimmi, C, Bertoldo, E, Morovic-Vergles, J, Culo, Im, Pecher, Ac, Santamaria, Vo, Heitmann, S, Codagnone, M, Pflugfelder, J, Krasowska, D, Michalska-Jakubus, M, Seidel, M, Hasler, P, Kretschmar, S, Kohm, M, Bajocchi, G, Salvador, Mj, Silva, Japd, Stamenkovic, B, Stankovic, A, Selmi, Cf, Santis, M, Ceribelli, A, Garzanova, L, Koneva, O, Starovoytova, M, Herrick, A, Puppo, F, Negrini, S, Murdaca, G, Engelhart, M, Szücs, G, Szamosi, S, de la Puente, C, Grande, Cs, Villanueva, Mjg, Midtvedt, Sø, Hoffmann-Vold, Am, Launay, D, Sobanski, V, Riccieri, V, Vasile, M, Ionescu, Rm, Opris, D, Sha, A, Woods, A, Gheorghiu, Am, Bojinca, M, Sunderkötter, C, Ehrchen, J, Ingegnoli, F, Mouthon, L, Dunogue, B, Chaigne, B, Legendre, P, Cantatore, Fp, Corrado, A, Ullman, S, Iversen, L, von Mühlen CA, Pozzi, Mr, Eyerich, K, Lauffer, F, Wiland, P, Szmyrka-Kaczmarek, M, Sokolik, R, Morgiel, E, Madej, M, Vanthuyne, M, Frédéric, H, Alegre-Sancho, Jj, Aringer, M, Herrmann, K, Günther, C, Westhovens, R, Langhe, E, Lenaerts, J, Anic, B, Baresic, M, Mayer, M, Üprus, M, Otsa, K, Yavuz, S, Granel, B, Radominski, Sc, De, C, Müller, S, Azevedo, Vf, Mendoza, F, Busquets, J, Popa, S, Agachi, S, Zenone, T, Pileckyte, M, Stebbings, S, Mathieu, A, Vacca, A, Sampaio-Barros, Pd, Stamp, L, Solanki, K, Silva, C, Schollum, J, Barns-Graham, H, Veale, D, O'Rourke, M, Loyo, E, Tineo, C, Paulino, G, Mohamed, Waaa, Rosato, E, Gigante, A, Oksel, F, Yargucu, F, Tanaseanu, Cm, Popescu, M, Dumitrascu, A, Tiglea, I, Foti, R, Visalli, E, Benenati, A, Amato, G, Ancuta, C, Villiger, P, Adler, S, Fröhlich, J, Kayser, C, Eduardo, Al, Fathi, N, Alii, S, Ahmed, M, Hasaneen, S, Hakeem, Ee, de la PG, Lefebvre, P, Martin, Jjg, Sibilia, J, Chatelus, E, Gottenberg, Je, Chifflot, H, Litinsky, I, Galdo, Fd, Abignano, G, Eng, S, Seskute, G, Butrimiene, I, Rugiene, R, Karpec, D, Pascal, M, Kerzberg, E, Bianchi, W, Bianchi, Bv, Bianchi, Dv, Barcellos, Y, Castellví, I, Millan, M, Limonta, M, Rimar, D, Rosner, I, Slobodin, G, Couto, M, Spertini, F, Ribi, C, Buss, G, Marcoccia, A, Bondanini, F, Ciani, A, Kahl, S, Hsu, Vm, Martin, T, Poindron, V, Meghit, K, Moiseev, S, Novikov, P, Chung, L, Kolstad, K, Stark, M, Schmeiser, T, Thiele, A, Majewski, D, Zdrojewski, Z, Zaneta, S, Wierzba, K, Martínez-Barrio, J, López-Longo, Fj, Bernardino, V, Moraes-Fontes, Mf, Rodrigues, Ac, Riemekasten, G, Sommerlatte, S, Jendreck, S, Arnold, S, Levy, Y, Rezus, E, Cardoneanu, A, Burlui, Am, Pamuk, On, Puttini, Ps, Talotta, R, Bongiovanni, S, Poormoghim, H, Andalib, E, Almasi, S, Kötter, I, Krusche, M, Cuomo, G, Danzo, F, Masini, F, Gaches, F, Michaud, M, Cartos, F, Belloli, L, Casu, C, Sfikakis, P, Tektonidou, M, Furst, D, Feldman, Gr, Ramazan, Am, Nurmambet, E, Miroto, A, Suta, C, Andronache, I, Huizinga, Twj, de Vries-Bouwstra, J., Chizzolini, Carlo, Jaeger, Veronika K, Tikly, Mohammed, Xu, Dong, Siegert, Elise, Hachulla, Eric, Airò, Paolo, Valentini, Gabriele, Matucci Cerinic, Marco, Distler, Oliver, Cozzi, Franco, Carreira, Patricia, Allanore, Yannick, Müller-Ladner, Ulf, Ananieva, Lidia P, Balbir-Gurman, Alexandra, Distler, Jörg H W, Czirják, Laszlo, Li, Mengtao, Henes, Jörg, Jimenez, Sergio A, Smith, Vanessa, Damjanov, Nemanja, Denton, Christopher P, Delgaldo, Francesco, Saketkoo, Lesley Ann, Walker, Ulrich A, University of Zurich, Cerinic, Marco Matucci, Walker Ulrich, A, Randone, Silvia Bellando, Bannert, Bettina, Iannone, Florenzoaa, Maurer, Brittaab, Jordan, Suzanaab, Dobrota, Rucsandraab, Becker, Mikeab, Mihai, Carinaa, Becvarare, Radima, Tomcik, Michala, Bielecka, Otylia Kowala, Gindzienska-Sieskiewicz, Ewaa, Karaszewska, Katarzynaa, Cutolo, Maurizioa, Pizzorni, Carmena, Paolino, Sabrinaae, Sulli, Albertoa, Ruaro, Barbara, Alessandri, Elisa, Riccardi, Antonella, Giacco, Veronica, Messitini, Valentina, Irace, Rosaria, Kedor, Claudia, Casteleyn, Vincent, Hilger, Julia, Hoeppner, Jakob, Rednic, Simona, Szabo, Iulia, Petcu, Ana, Avouac, Jérome, Camelia, Frantz, Desbas, Carole, Vlachoyiannopoulos, Panayioti, Montecucco, Carlo Maurizio, Caporali, Roberto, Cavagna, Lorenzo, Stork, Jiri, Inanc, Murat, Joven, Beatriz E., Novak, Srdan, Anic, Felina, Varju, Cecilia, Minier, Tunde, Allai, Daniela, Kucharz, Eugene J., Kotulska, Anna, Kopec-Medrek, Magdalena, Widuchowska, Malgorzata, Dolnicar, Alenka Sipek, Coleiro, Bernard, Gabrielli, Armando, Manfredi, Lucia, Benfaremo, Devi, Ferrarini, Alessia, Bancel, Dominique Farge, Hij, Adrian, Lazzaroni, Maria Grazia, Hesselstrand, Roger, Wuttge, Dirk, Andréasson, Kristofer, Martinovic, Duska, Bozic, Ivona, Radic, Mislav, Braun-Moscovici, Yolanda, Monaco, Andrea Lo, Furini, Federica, Hunzelmann, Nicola, Moinzadeh, Pia, Pellerito, Raffaele, Caimmi, Cristian, Bertoldo, Eugenia, Morovic-Vergles, Jadranka, Culo, Ivana Melanie, Pecher, Ann-Christian, Santamaria, Vera Ortiz, Heitmann, Stefan, Codagnone, Medeleine, Pflugfelder, Johanne, Krasowska, Dorota, Michalska-Jakubus, Malgorzata, Seidel, Matthia, Hasler, Paul, Kretschmar, Samuel, Kohm, Michaela, Bajocchi, Gianluigi, Salvador, Maria João, Da Silva, JoséAntonio Pereira, Stamenkovic, Bojana, Stankovic, Aleksandra, Selmi, Carlo Francesco, De Santis, Maria, Ceribelli, Angela, Garzanova, Ludmila, Koneva, Olga, Starovoytova, Maya, Herrick, Ariane, Puppo, Francesco, Negrini, Simone, Murdaca, Giuseppe, Engelhart, Merete, Szücs, Gabriela, Szamosi, Szilvia, De La Puente, Carlo, Grande, Cristina Sobrino, Villanueva, Maria Jesus Garcia, Midtve, Øyvindbw, Hoffmann-Vold, Anna-Mariabw, Launay, Davidbx, Sobanski, Vincentbx, Riccieri, Valeriaby, Vasile, Massimilianoby, Stefantoni, Katia, Ionescu, Ruxandra Maria, Opris, Daniela, Sha, Ami, Woods, Adrianne, Gheorghiu, Ana Maria, Bojinca, Mihai, Sunderkötter, Cord, Ehrchen, Jan, Ingegnoli, Francesca, Mouthon, Luc, Dunogue, Bertrand, Chaigne, Benjamin, Legendre, Paul, Cantatore, Francesco Paolo, Corrado, Ada, Ullman, Susanne, Iversen, Line, Von Mühlen, Carlos Alberto, Pozzi, Maria Rosa, Eyerich, Kilian, Lauffer, Felix, Wiland, Piotr, Szmyrka-Kaczmarek, Magdalena, Sokolik, Renata, Morgiel, Ewa, Madej, Marta, Vanthuyne, Marie, Frédéric, Houssiau, Alegre-Sancho, Juan Jose, Aringer, Martin, Herrmann, Kristine, Günther, Claudia, Westhovens, Rene, De Langhe, Ellen, Lenaerts, Jan, Anic, Branimir, Baresic, Marko, Mayer, Miroslav, Üprus, Maria, Otsa, Kati, Yavuz, Sule, Granel, Brigitte, Radominski, Sebastião Cezar, De Souza Müller, Carolina, Feijóazevedo, Valderílio, Mendoza, Fabian, Busquets, Joanna, Popa, Sergei, Agachi, Svetlana, Zenone, Thierry, Pileckyte, Margarita, Stebbings, Simon, Jordan, Sarah, Mathieu, Alessandro, Vacca, Alessandra, Sampaio-Barros, Percival D., Stamp, Lisa, Solanki, Kamal, Silva, Cherumi, Schollum, Joanne, Barns-Graham, Helen, Veale, Dougla, O'Rourke, Marie, Loyo, Esthela, Tineo, Carmen, Paulino, Glenny, Mohamed, Walid Ahmed Abdel Atty, Rosato, Edoardo, Gigante, Antonietta, Oksel, Fahrettin, Yargucu, Figen, Tanaseanu, Cristina-Mihaela, Popescu, Monica, Dumitrascu, Alina, Tiglea, Isabela, Foti, Rosario, Visalli, Elisa, Benenati, Alessia, Amato, Giorgio, Ancuta, Codrina, Villiger, Peter, Adler, Sabine, Fröhlich, Johanne, Kayser, Cristiane, Eduardo, Andrade Lui, Fathi, Nihal, Alii, Safa, Ahmed, Marrow, Hasaneen, Samar, El Hakeem, Eman, De La Peña Lefebvre, Paloma García, Martin, Jorge Juan Gonzalez, Sibilia, Jean, Chatelus, Emmanuel, Gottenberg, Jacques Eric, Chifflot, Hélène, Litinsky, Ira, Del Galdo, Francesco, Abignano, Giuseppina, Eng, Sookho, Seskute, Goda, Butrimiene, Irena, Rugiene, Rita, Karpec, Diana, Pascal, Melanie, Kerzberg, Eduardo, Bianchi, Washington, Bianchi, Breno Valdetaro, Bianchi, Dante Valdetaro, Barcellos, Yeda, Castellví, Ivan, Millan, Milena, Limonta, Massimiliano, Rimar, Doron, Rosner, Itzhak, Slobodin, Gleb, Couto, Maura, Spertini, Françoi, Ribi, Camillo, Buss, Guillaume, Marcoccia, Antonella, Bondanini, Francesco, Ciani, Aldo, Kahl, Sarah, Hsu, Vivien M., Martin, Thierry, Poindron, Vincent, Meghit, Kilifa, Moiseev, Sergey, Novikov, Pavel, Chung, Lori, Kolstad, Kathleen, Stark, Marianna, Schmeiser, Tim, Thiele, Astrid, Majewski, Dominik, Zdrojewski, Zbigniew, Zaneta, Smolenska, Wierzba, Karol, Martínez-Barrio, Julia, López-Longo, Francisco Javier, Bernardino, Vera, Moraes-Fontes, Maria Francisca, Rodrigues, Ana Catarina, Riemekasten, Gabriela, Sommerlatte, Sabine, Jendreck, Sebastian, Arnold, Sabrina, Levy, Yair, Rezus, Elena, Cardoneanu, Anca, Burlui, Alexandra Maria, Pamuk, Omer Nuri, Puttini, Piercarlo Sarzi, Talotta, Rossella, Bongiovanni, Sara, Poormoghim, Hadi, Andalib, Elham, Almasi, Simin, Kötter, Ina, Krusche, Matrin, Cuomo, Giovanna, Danzo, Fiammetta, Masini, Francesco, Gaches, Franci, Michaud, Martin, Cartos, Florian, Belloli, Laura, Casu, Cinzia, Sfikakis, Petro, Tektonidou, Maria, Furst, Daniel, Feldman, Gary R., Ramazan, Ana-Maria, Nurmambet, Emel, Miroto, Amalia, Suta, Cristina, Andronache, Iulia, Huizinga, Tom W. J., De Vries-Bouwstra, Jeska, and Walker, Ulrich A.

Subjects
Male, Vital capacity, Organ manifestations, systemic sclerosis, Type I, race difference, Systemic scleroderma, Gastroenterology, Scleroderma, immunology, 0302 clinical medicine, Diffusing capacity, middle aged, pulmonary hypertension, Medicine, Pharmacology (medical), 030212 general & internal medicine, organ manifestations, races, skin and connective tissue diseases, Lung, race, pathophysiology, African Continental Ancestry Group, ddc:616, integumentary system, disease course, Hazard ratio, Races, 10051 Rheumatology Clinic and Institute of Physical Medicine, Pulmonary, Middle Aged, Blacks, cohort analysis, Autoantibodie, 3. Good health, Asians, female, priority journal, DNA Topoisomerases, Type I, Black, centromere, Cohort, Hypertension, organ manifestation, Systemic sclerosis, Female, systemic sclerosi, Human, Adult, Asian Continental Ancestry Group, medicine.medical_specialty, Hypertension, Pulmonary, European Continental Ancestry Group, Black People, 610 Medicine & health, complication, Caucasian, White People, Article, lung, 03 medical and health sciences, Black person, Rheumatology, Asian People, forced vital capacity, Internal medicine, geographic distribution, Humans, controlled study, human, DNA topoisomerase, Aged, Autoantibodies, 030203 arthritis & rheumatology, Scleroderma, Systemic, Asian, business.industry, Whites, Systemic, Odds ratio, medicine.disease, Pulmonary hypertension, major clinical study, mortality, clinical feature, business, DNA Topoisomerases, autoantibody
Abstract

Objectives Racial factors play a significant role in SSc. We evaluated differences in SSc presentations between white patients (WP), Asian patients (AP) and black patients (BP) and analysed the effects of geographical locations. Methods SSc characteristics of patients from the EUSTAR cohort were cross-sectionally compared across racial groups using survival and multiple logistic regression analyses. Results The study included 9162 WP, 341 AP and 181 BP. AP developed the first non-RP feature faster than WP but slower than BP. AP were less frequently anti-centromere (ACA; odds ratio (OR) = 0.4, P < 0.001) and more frequently anti-topoisomerase-I autoantibodies (ATA) positive (OR = 1.2, P = 0.068), while BP were less likely to be ACA and ATA positive than were WP [OR(ACA) = 0.3, P < 0.001; OR(ATA) = 0.5, P = 0.020]. AP had less often (OR = 0.7, P = 0.06) and BP more often (OR = 2.7, P < 0.001) diffuse skin involvement than had WP. AP and BP were more likely to have pulmonary hypertension [OR(AP) = 2.6, P < 0.001; OR(BP) = 2.7, P = 0.03 vs WP] and a reduced forced vital capacity [OR(AP) = 2.5, P < 0.001; OR(BP) = 2.4, P < 0.004] than were WP. AP more often had an impaired diffusing capacity of the lung than had BP and WP [OR(AP vs BP) = 1.9, P = 0.038; OR(AP vs WP) = 2.4, P < 0.001]. After RP onset, AP and BP had a higher hazard to die than had WP [hazard ratio (HR) (AP) = 1.6, P = 0.011; HR(BP) = 2.1, P < 0.001]. Conclusion Compared with WP, and mostly independent of geographical location, AP have a faster and earlier disease onset with high prevalences of ATA, pulmonary hypertension and forced vital capacity impairment and higher mortality. BP had the fastest disease onset, a high prevalence of diffuse skin involvement and nominally the highest mortality.

Published
2020

21. Cryogenic characterization of a $$\hbox {LiAlO}_{2}$$ crystal and new results on spin-dependent dark matter interactions with ordinary matter

Author

Abdelhameed, A. H., Angloher, G., Bauer, P., Bento, A., Bertoldo, E., Breier, R., Bucci, C., Canonica, L., D???addabbo, A., Di Lorenzo, S., Erb, A., Feilitzsch, F. V., Ferreiro Iachellini, N., Fichtinger, S., Fuchs, D., Fuss, A., Ghete, V. M., Garai, A., Gorla, P., Hauff, D., Je??kovsk??, M., Jochum, J., Kaizer, J., Kaznacheeva, M., Kinast, A., Kluck, H., Kraus, H., Langenk??mper, A., Mancuso, M., Mokina, V., Mondragon, E., Olmi, M., Ortmann, T., Pagliarone, C., Palu??ov??, V., Pattavina, L., Petricca, F., Potzel, W., Povinec, P., Pr??bst, F., Reindl, F., Rothe, J., Sch??ffner, K., Schieck, J., Schipperges, V., Schmiedmayer, D., Sch??nert, S., Schwertner, C., Stahlberg, M., Stodolsky, L., Strandhagen, C., Strauss, R., Usherov, I., Wagner, F., Willers, M., Zema, V., Zeman, J., Br??tzam, M., and Ganschow, S.

Subjects
Dark matter · Cryogenics · Spin-Dependent · Lithium · Neutrons
Published
2020

22. First results from the CRESST-III low-mass dark matter program

Author

CRESST Collaboration, Abdelhameed, A. H., Angloher, G., Bauer, P., Bento, A., Bertoldo, E., Bucci, C., Canonica, L., D'Addabbo, A., Defay, X., Di Lorenzo, S., Erb, A., Feilitzsch, F. v., Fichtinger, S., Iachellini, N. Ferreiro, Fuss, A., Gorla, P., Hauff, D., Jochum, J., Kinast, A., Kluck, H., Kraus, H., Langenkämper, A., Mancuso, M., Mokina, V., Mondragon, E., Münster, A., Olmi, M., Ortmann, T., Pagliarone, C., Pattavina, L., Petricca, F., Potzel, W., Pröbst, F., Reindl, F., Rothe, J., Schäffner, K., Schieck, J., Schipperges, V., Schmiedmayer, D., Schönert, S., Schwertner, C., Stahlberg, M., Stodolsky, L., Strandhagen, C., Strauss, R., Türkoglu, C., Usherov, I., Willers, M., and Zema, V.

Subjects
Physics, Scintillation, Cosmology and Nongalactic Astrophysics (astro-ph.CO), Dark Matter, Cryogeny, Calorimeter (particle physics), Phonon, Physics::Instrumentation and Detectors, Dark matter, Detector, Astrophysics::Instrumentation and Methods for Astrophysics, FOS: Physical sciences, Nuclear physics, Recoil, Particle, Dark Matter, Cryogeny, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Light dark matter, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

The CRESST experiment is a direct dark matter search which aims to measure interactions of potential dark matter particles in an earth-bound detector. With the current stage, CRESST-III, we focus on a low energy threshold for increased sensitivity towards light dark matter particles. In this manuscript we describe the analysis of one detector operated in the first run of CRESST-III (05/2016-02/2018) achieving a nuclear recoil threshold of 30.1eV. This result was obtained with a 23.6g CaWO$_4$ crystal operated as a cryogenic scintillating calorimeter in the CRESST setup at the Laboratori Nazionali del Gran Sasso (LNGS). Both the primary phonon/heat signal and the simultaneously emitted scintillation light, which is absorbed in a separate silicon-on-sapphire light absorber, are measured with highly sensitive transition edge sensors operated at ~15mK. The unique combination of these sensors with the light element oxygen present in our target yields sensitivity to dark matter particle masses as low as 160MeV/c$^2$., 9 pages, 9 figures

Published
2019

23. First results on sub-GeV spin-dependent dark matter interactions with $$^{7}$$ <math><msup><mrow></mrow><mn>7</mn></msup></math> Li

Author

Abdelhameed, A., Angloher, G., Bauer, P., Bento, A., Bertoldo, E., Bucci, C., Canonica, L., D’Addabbo, A., Defay, X., Lorenzo, S., Erb, A., Feilitzsch, F., Iachellini, N., Fichtinger, S., Fuss, A., Gorla, P., Hauff, D., Jochum, J., Kinast, A., Kluck, H., Kraus, H., Langenkämper, A., Mancuso, M., Mokina, V., Mondragon, E., Münster, A., Olmi, M., Ortmann, T., Pagliarone, C., Pattavina, L., Petricca, F., Potzel, W., Pröbst, F., Reindl, F., Rothe, J., Schäffner, K., Schieck, J., Schipperges, V., Schmiedmayer, D., Schönert, S., Schwertner, C., Stahlberg, M., Stodolsky, L., Strandhagen, C., Strauss, R., Türkoğlu, C., Usherov, I., Willers, M., Zema, V., Chapellier, M., Giuliani, A., Nones, C., Poda, D., Shlegel, V., Velázquez, M., and Zolotarova, A.

Abstract

In this work, we want to highlight the potential of lithium as a target for spin-dependent dark matter search in cryogenic experiments, with a special focus on the low-mass region of the parameter space. We operated a prototype detector module based on a $$\hbox {Li}_2\hbox {MoO}_4$$ Li2MoO4 target crystal in an above-ground laboratory. Despite the high background environment, the detector sets a competitive limit on spin-dependent interactions of dark matter particles with protons and neutrons for masses between $$0.8~\hbox {GeV/c}^2$$ 0.8GeV/c2 and $$1.5~\hbox {GeV/c}^2$$ 1.5GeV/c2 .

Published
2019

27. Lithium-Containing Crystals for Light Dark Matter Search Experiments.

Author

Bertoldo, E., Abdelhameed, A. H., Angloher, G., Bauer, P., Bento, A., Breier, R., Bucci, C., Canonica, L., D'Addabbo, A., Di Lorenzo, S., Erb, A., Feilitzsch, F. V., Ferreiro Iachellini, N., Fichtinger, S., Fuchs, D., Fuss, A., Gorla, P., Hauff, D., Ješkovský, M., and Jochum, J.

Subjects
*DARK matter, *NEUTRON flux, *DIRECT currents, *CRYSTALS, *NEUTRONS
Abstract

In the current direct dark matter search landscape, the leading experiments in the sub-GeV mass region mostly rely on cryogenic techniques which employ crystalline targets. One attractive type of crystals for these experiments is those containing lithium, due to the fact that 7 Li is an ideal candidate to study spin-dependent dark matter interactions in the low mass region. Furthermore, 6 Li can absorb neutrons, a challenging background for dark matter experiments, through a distinctive signature which allows the monitoring of the neutron flux directly on site. In this work, we show the results obtained with three different detectors based on LiAlO 2 , a target crystal never used before in cryogenic experiments. [ABSTRACT FROM AUTHOR]

Published
2020
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28. Searches for Light Dark Matter with the CRESST-III Experiment.

Author

Mancuso, M., Abdelhameed, A. H., Angloher, G., Breier, R., Bauer, P., Bento, A., Bertoldo, E., Bucci, C., Canonica, L., D'Addabbo, A., Di Lorenzo, S., Erb, A., von Feilitzsch, F., Ferreiro Iachellini, N., Fichtinger, S., Fuss, A., Gorla, P., Hauff, D., Jes̆kovský, M., and Jochum, J.

Subjects
DARK matter, NUCLEAR energy, THRESHOLD energy, DETECTORS
Abstract

Cryogenic Rare Event Search with Superconducting Thermometers (CRESST) is a long-standing direct dark matter detection experiment with cryogenic detectors located at the underground facility Laboratori Nazionali del Gran Sasso in Italy. CRESST-III, the third generation of CRESST, was specifically designed to have a world-leading sensitivity for low-mass dark matter (DM) (less than 2 GeV/ c 2 ) to probe the spin-independent DM-nucleus cross section. At present, a large part of the parameter space for spin-independent scattering off nuclei remains untested for dark matter particles with masses below few GeV/ c 2 although many motivated theoretical models having been proposed. The CRESST-III experiment employs scintillating CaWO 4 crystals of ∼ 25 g as target material for dark matter interactions operated as cryogenic scintillating calorimeters at ∼ 10 mK. CRESST-III first data taking was successfully completed in 2018, achieving an unprecedented energy threshold for nuclear recoils. This result extended the present sensitivity to DM particles as light as ∼ 160 MeV/ c 2 . In this paper, an overview of the CRESST-III detectors and results will be presented. [ABSTRACT FROM AUTHOR]

Published
2020
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31. Paradoxical Raynaud's phenomenon following iloprost infusion in a patient with systemic sclerosis.

Author

Bertelle, D, Bertoldo, E, Bixio, R, and Rossini, M

Subjects
*RAYNAUD'S disease, *SYSTEMIC scleroderma, *CYCLIC adenylic acid, *PULMONARY hypertension
Abstract

Here, we describe the case of a patient with systemic sclerosis (SSc) who developed paradoxical Raynaud's phenomenon (RP) following iloprost infusion. Intravenous therapy with iloprost is a mainstay of the treatment of systemic sclerosis-related Raynaud's phenomenon (SSc-RP), and it is currently advised by the European League Against Rheumatism (EULAR) recommendation ([1]). [Extracted from the article]

Published
2023
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34. Limits on dark matter effective field theory parameters with CRESST-II.

Author

Angloher, G., Bauer, P., Bento, A., Bertoldo, E., Bucci, C., Canonica, L., D'Addabbo, A., Defay, X., Lorenzo, S. Di, Erb, A., Feilitzsch, F. v., Ferreiro Iachellini, N., Gorla, P., Hauff, D., Jochum, J., Kiefer, M., Kluck, H., Kraus, H., Langenkämper, A., and Mancuso, M.

Subjects
PARTICULATE matter, CRYSTAL chemical bonds, DATA analysis, THEORY of constraints, INTERSTELLAR medium
Abstract

CRESST is a direct dark matter search experiment, aiming for an observation of nuclear recoils induced by the interaction of dark matter particles with cryogenic scintillating calcium tungstate crystals. Instead of confining ourselves to standard spin-independent and spin-dependent searches, we re-analyze data from CRESST-II using a more general effective field theory (EFT) framework. On many of the EFT coupling constants, improved exclusion limits in the low-mass region (< 3-4 GeV/c2) are presented. [ABSTRACT FROM AUTHOR]

Published
2019
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35. DarkSide-20k: A 20 tonne two-phase LAr TPC for direct dark matter detection at LNGS

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Craig E. Aalseth, P. F. Loverre, T. Viant, Fabrizio Giulio Luca Pilo, A. Vishneva, R. Perruzza, E. Segreto, P. Garcia Abia, T. N. Johnson, Manuel Colocci, Lelio Luzzi, R. Tartaglia, M. Bossa, S. Murphy, I. N. Machulin, M. Razeti, V. Pavletcov, M. Kuźniak, H. O. Back, N. Canci, P. D. Meyers, A.V. Shchagin, R. Cereseto, P. Skensved, Jocelyn Monroe, A. Buzulutskov, Davide Portaluppi, Giovanni Covone, G. Dellacasa, Vittorio Cataudella, P. Giampa, B. Rossi, D. Korablev, V. Pesudo, André Rubbia, Marco Pallavicini, Ivone F. M. Albuquerque, K. Fomenko, G. Fiorillo, G. Testera, K. Pelczar, A. Dolgov, F. Retiere, L. Shekhtman, George E. Froudakis, Mariano Cadoni, A. Moggi, L. Romero, M. La Commara, Aldo Ghisi, P. Cavalcante, S. Corgiolu, A. Oleinik, E. V. Hungerford, Cristiano Galbiati, Piero Salatino, D. D'Urso, M. Wada, Rosario Nania, M. Rescigno, Yuting Wang, T. Pollmann, Alan Watson, N. Rossi, C. J. Jillings, F. Gabriele, A. Empl, M. G. Boulay, S. Sanfilippo, A. Mandarano, S. J. M. Peeters, L. Pagani, M. D'Incecco, Alessandro Ferri, S. Westerdale, K. Keeter, R. Bunker, Claudio Piemonte, Andrea Alici, Federica Villa, D. Sablone, G. Di Pietro, Gilda Scioli, Allen Seifert, Marisa Gulino, P. Trinchese, G. Bonfini, S. Catalanotti, F. Granato, D. A. Semenov, M. Carlini, Luciano Pandola, A. Sotnikov, Min-Xin Guan, Alberto Tosi, H. Qian, M. D. Skorokhvatov, S. Bettarini, A. de Candia, An. Ianni, A. Sheshukov, W. Bonivento, V. Regazzoni, E. Pantic, F. Speziale, M. Mayer, Annalisa Vacca, X. Xiang, P. N. Singh, M. Gromov, S. Wu, A. G. Cocco, V. N. Muratova, B. Bottino, Andrea Gabrieli, Mario Giorgi, E. Sanchez Garcia, Jay W. Grate, Y. Suvorov, R. Milincic, G. Batignani, E. Bertoldo, M. Orsini, B. Radics, Giuseppe Longo, C. L. Kendziora, S. Bussino, M. Ave, V. Bocci, B. Reinhold, S. Dussoni, Eugenio Scapparone, A. L. Hallin, Richard M. Williams, S. Horikawa, B. Hosseini, S. Kim, D. Hughes, I. D'Antone, A. M. Goretti, A. S. Chepurnov, C. Giganti, I. J. Arnquist, Antonino Zichichi, A. Castellani, M. Fernandez Diaz, A. L. Renshaw, C. Filip, Silvia Arcelli, Fabio Acerbi, D. M. Asner, Monica Verducci, Marco Sant, Giovanni Paternoster, C. Dionisi, M. Da Rocha Rolo, S. Davini, C. J. Martoff, M. Marcante, M. Cadeddu, Paul H. Humble, E. Paoloni, Z. Ye, C. Cicalo, W. Mu, Laura A. Pellegrini, F. Pazzona, A. S. Kubankin, C. Savarese, G. Sobrero, Stefano Giagu, M. Caravati, A. A. Machado, Chung-Yao Yang, N. N. Nurakhov, G. Koh, Paolo Crivelli, M. Carpinelli, S. De Cecco, Fausto Ortica, G. De Rosa, I. Dormia, Federico Perotti, A. Yllera de Llano, Franco Zappa, J. Wahl, M. Guerzoni, Andrea Messina, Pietro Antonioli, Rudi Lussana, C. Cantini, Pierfranco Demontis, B. Vogelaar, O. Gorchakov, Angelo Rivetti, Simonetta Palmas, Hui Wang, Ben Loer, A. Devoto, J. Walding, Paolo Musico, Alberto Gola, G. Gibertoni, Thomas Alexander, I. Nikulin, D. A. Pugachev, R. Stainforth, A. Monte, A. V. Derbin, Andrey Sokolov, G. Zuzel, J. Maricic, A. B. McDonald, A. Zullo, L. Cifarelli, R. Santorelli, Giuseppe Baldovino Suffritti, Yanhui Ma, B. Schlitzer, Marino Simeone, Stefania Moioli, D. Franco, Michele Mascia, Mario Mariani, Raffaele Ardito, M. K. Daniel, C. Stanford, Mauro Citterio, A.E. Bondar, Caoxiang Zhu, O. Samoylov, Francesco Ragusa, R. K. Haaland, A. Gendotti, M. De Deo, G. Y. Grigoriev, A. Caminata, A. K. Alton, G. U. Lodi, G. Korga, Q. Riffard, M. Zullo, Xiujiang Li, Marco Grassi, M. Della Valle, C. Regenfus, Eric W. Hoppe, E. Vázquez-Jáuregui, L. Mapelli, Stefano Maria Mari, A. Tonazzo, A. Barrado Olmedo, V. Oleynikov, F. Di Eusanio, Maria Giuseppina Bisogni, B. J. Mount, Matteo Morrocchi, M. Kuss, E. Shemyakina, A. Candela, Aldo Romani, P. Agnes, G. K. Giovanetti, B. Lehnert, A. Razeto, Stefano Cavuoti, A. Navrer Agasson, V. Nosov, M. Cariello, N. Pelliccia, Simone Rizzardini, G. De Guido, M. Lissia, G. De Filippis, Marcin Wójcik, Anselmo Margotti, Xiang Xiao, Marcelo Braga Bueno Guerra, W. Sands, M. L. Gligan, A. O. Nozdrina, F. Raffaelli, G. Zappalà, A. Pocar, O. Smirnov, E. V. Unzhakov, B. Harrop, Istituto Nazionale di Fisica Nucleare, Sezione di Bologna (INFN, Sezione di Bologna), Istituto Nazionale di Fisica Nucleare (INFN), LVMH Recherche, LVMH Moët Hennessy Louis Vuitton, Dipartimento di Scienze Fisiche [Naples], Università degli studi di Napoli Federico II, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Dipartimento di Meccanica, Matematica e Management Politecnico di Bari, AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Istituto Nazionale di Fisica Nucleare [Pisa] (INFN), Department of Electrical Engineering, University of Pavia, Laboratorio de Instrumentaçao, Engenharia Biomédica e Fisica da Radiaçao (LIBPhys-UNL), Departamento de Fìsica [Lisboa] (DF), Faculdade de Ciências e Tecnologia = School of Science & Technology (FCT NOVA), Universidade Nova de Lisboa = NOVA University Lisbon (NOVA)-Universidade Nova de Lisboa = NOVA University Lisbon (NOVA)-Faculdade de Ciências e Tecnologia = School of Science & Technology (FCT NOVA), Universidade Nova de Lisboa = NOVA University Lisbon (NOVA)-Universidade Nova de Lisboa = NOVA University Lisbon (NOVA), Paul Scherrer Institute (PSI), Istituto Nazionale di Fisica Nucleare, Sezione di Napoli (INFN, Sezione di Napoli), Biochimie et Physiologie Moléculaire des Plantes (BPMP), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Laboratoire de Biochimie et Biologie Moléculaire Végétales - UMR6134, Université Pascal Paoli (UPP)-Centre National de la Recherche Scientifique (CNRS), Department of Geological Sciences, University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique (LERMA), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université de Cergy Pontoise (UCP), Université Paris-Seine-Université Paris-Seine-Centre National de la Recherche Scientifique (CNRS), Istituto Nazionale di Fisica Nucleare, Sezione di Torino (INFN, Sezione di Torino), Migration et différenciation des cellules souches hématopoiétiques = Migration and differentiation of hematopoietic stem cells (LBD-E06), Institut National de la Santé et de la Recherche Médicale (INSERM)-Laboratoire de Biologie du Développement (LBD), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Department of Microsystems Engineering [Freiburg] (IMTEK), University of Freiburg [Freiburg], Pondicherry Univrsity, Department of Earth Sciences, School of Physical, Chemical & Applied Sciences, Rhodes University, Grahamstown, inconnu, Inconnu, Key Lab of Computer System and Architecture, Institute of Computing Technology [Beijing] (ICT), Chinese Academy of Sciences [Beijing] (CAS), Centre for Ultrahigh Bandwidth Devices for Optical Systems (CUDOS), Macquarie University, Laboratoire Géophysique et évaluation non destructive (IFSTTAR/GERS/GeoEND), Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)-PRES Université Nantes Angers Le Mans (UNAM), Aalseth, C. E., Acerbi, F., Agnes, P., Albuquerque, I. F. M., Alexander, T., Alici, A., Alton, A. K., Antonioli, P., Arcelli, S., Ardito, R., Arnquist, I. J., Asner, D. M., Ave, M., Back, H. O., Barrado Olmedo, A. I., Batignani, G., Bertoldo, E., Bettarini, S., Bisogni, M. G., Bocci, V., Bondar, A., Bonfini, G., Bonivento, W., Bossa, M., Bottino, B., Boulay, M., Bunker, R., Bussino, S., Buzulutskov, A., Cadeddu, M., Cadoni, M., Caminata, A., Canci, N., Candela, A., Cantini, C., Caravati, M., Cariello, M., Carlini, M., Carpinelli, M., Castellani, A., Catalanotti, S., Cataudella, V., Cavalcante, P., Cavuoti, S., Cereseto, R., Chepurnov, A., Cicalò, C., Cifarelli, L., Citterio, M., Cocco, A. G., Colocci, M., Corgiolu, S., Covone, G., Crivelli, P., D’Antone, I., D’Incecco, M., D’Urso, D., Da Rocha Rolo, M. D., Daniel, M., Davini, S., de Candia, A., De Cecco, S., De Deo, M., De Filippis, G., De Guido, G., De Rosa, G., Dellacasa, G., Della Valle, M., Demontis, P., Derbin, A., Devoto, A., Di Eusanio, F., Di Pietro, G., Dionisi, C., Dolgov, A., Dormia, I., Dussoni, S., Empl, A., Fernandez Diaz, M., Ferri, A., Filip, C., Fiorillo, G., Fomenko, K., Franco, D., Froudakis, G. E., Gabriele, F., Gabrieli, A., Galbiati, C., Garcia Abia, P., Gendotti, A., Ghisi, A., Giagu, S., Giampa, P., Gibertoni, G., Giganti, C., Giorgi, M. A., Giovanetti, G. K., Gligan, M. L., Gola, A., Gorchakov, O., Goretti, A. M., Granato, F., Grassi, M., Grate, J. W., Grigoriev, G. Y., Gromov, M., Guan, M., Guerra, M. B. B., Guerzoni, M., Gulino, M., Haaland, R. K., Hallin, A., Harrop, B., Hoppe, E. W., Horikawa, S., Hosseini, B., Hughes, D., Humble, P., Hungerford, E. V., Ianni, An., Jillings, C., Johnson, T. N., Keeter, K., Kendziora, C. L., Kim, S., Koh, G., Korablev, D., Korga, G., Kubankin, A., Kuss, M., Kuźniak, M., La Commara, M., Lehnert, B., Li, X., Lissia, M., Lodi, G. U., Loer, B., Longo, G., Loverre, P., Lussana, R., Luzzi, L., Ma, Y., Machado, A. A., Machulin, I. N., Mandarano, A., Mapelli, L., Marcante, M., Margotti, A., Mari, S. M., Mariani, M., Maricic, J., Martoff, C. J., Mascia, M., Mayer, M., Mcdonald, A. B., Messina, A., Meyers, P. D., Milincic, R., Moggi, A., Moioli, S., Monroe, J., Monte, A., Morrocchi, M., Mount, B. J., Mu, W., Muratova, V. N., Murphy, S., Musico, P., Nania, R., Navrer Agasson, A., Nikulin, I., Nosov, V., Nozdrina, A. O., Nurakhov, N. N., Oleinik, A., Oleynikov, V., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Palmas, S., Pandola, L., Pantic, E., Paoloni, E., Paternoster, G., Pavletcov, V., Pazzona, F., Peeters, S., Pelczar, K., Pellegrini, L. A., Pelliccia, N., Perotti, F., Perruzza, R., Pesudo, V., Piemonte, C., Pilo, F., Pocar, A., Pollmann, T., Portaluppi, D., Pugachev, D. A., Qian, H., Radics, B., Raffaelli, F., Ragusa, F., Razeti, M., Razeto, A., Regazzoni, V., Regenfus, C., Reinhold, B., Renshaw, A. L., Rescigno, M., Retière, F., Riffard, Q., Rivetti, A., Rizzardini, S., Romani, A., Romero, L., Rossi, B., Rossi, N., Rubbia, A., Sablone, D., Salatino, P., Samoylov, O., Sánchez García, E., Sands, W., Sanfilippo, S., Sant, M., Santorelli, R., Savarese, C., Scapparone, E., Schlitzer, B., Scioli, G., Segreto, E., Seifert, A., Semenov, D. A., Shchagin, A., Shekhtman, L., Shemyakina, E., Sheshukov, A., Simeone, M., Singh, P. N., Skensved, P., Skorokhvatov, M. D., Smirnov, O., Sobrero, G., Sokolov, A., Sotnikov, A., Speziale, F., Stainforth, R., Stanford, C., Suffritti, G. B., Suvorov, Y., Tartaglia, R., Testera, G., Tonazzo, A., Tosi, A., Trinchese, P., Unzhakov, E. V., Vacca, A., Vázquez-Jáuregui, E., Verducci, M., Viant, T., Villa, F., Vishneva, A., Vogelaar, B., Wada, M., Wahl, J., Walding, J., Wang, H., Wang, Y., Watson, A. W., Westerdale, S., Williams, R., Wojcik, M. M., Wu, S., Xiang, X., Xiao, X., Yang, C., Ye, Z., Yllera de Llano, A., Zappa, F., Zappalà, G., Zhu, C., Zichichi, A., Zullo, M., Zullo, A., Zuzel, G., National Institute for Nuclear Physics (INFN), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Unité de Catalyse et de Chimie du Solide - Site Artois (UCCS Artois), Université d'Artois (UA)-Université de Lille, Sciences et Technologies-Ecole Centrale de Lille-Ecole Nationale Supérieure de Chimie de Lille (ENSCL)-Centre National de la Recherche Scientifique (CNRS), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Faculdade de Ciências e Tecnologia (FCT NOVA), Universidade Nova de Lisboa (NOVA)-Universidade Nova de Lisboa (NOVA)-Faculdade de Ciências e Tecnologia (FCT NOVA), Universidade Nova de Lisboa (NOVA)-Universidade Nova de Lisboa (NOVA), Université de Montpellier (UM)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS), Université de Corse, CNRS UMR6134 SPE, Laboratoire de Biochimie et Biologie Moléculaire Végétales, École normale supérieure - Paris (ENS Paris)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université de Cergy Pontoise (UCP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Department of Microsystems Engineering - IMTEK, Rhodes University, Aalseth, C, Acerbi, F, Agnes, P, Albuquerque, I, Alexander, T, Alici, A, Alton, A, Antonioli, P, Arcelli, S, Ardito, R, Arnquist, I, Asner, D, Ave, M, Back, H, Barrado Olmedo, A, Batignani, G, Bertoldo, E, Bettarini, S, Bisogni, M, Bocci, V, Bondar, A, Bonfini, G, Bonivento, W, Bossa, M, Bottino, B, Boulay, M, Bunker, R, Bussino, S, Buzulutskov, A, Cadeddu, M, Cadoni, M, Caminata, A, Canci, N, Candela, A, Cantini, C, Caravati, M, Cariello, M, Carlini, M, Carpinelli, M, Castellani, A, Catalanotti, S, Cataudella, V, Cavalcante, P, Cavuoti, S, Cereseto, R, Chepurnov, A, Cicalo', C, Cifarelli, L, Citterio, M, Cocco, A, Colocci, M, Corgiolu, S, Covone, G, Crivelli, P, D’Antone, I, D’Incecco, M, D’Urso, D, Da Rocha Rolo, M, Daniel, M, Davini, S, de Candia, A, De Cecco, S, De Deo, M, De Filippis, G, De Guido, G, De Rosa, G, Dellacasa, G, Della Valle, M, Demontis, P, Derbin, A, Devoto, A, Di Eusanio, F, Di Pietro, G, Dionisi, C, Dolgov, A, Dormia, I, Dussoni, S, Empl, A, Fernandez Diaz, M, Ferri, A, Filip, C, Fiorillo, G, Fomenko, K, Franco, D, Froudakis, G, Gabriele, F, Gabrieli, A, Galbiati, C, Garcia Abia, P, Gendotti, A, Ghisi, A, Giagu, S, Giampa, P, Gibertoni, G, Giganti, C, Giorgi, M, Giovanetti, G, Gligan, M, Gola, A, Gorchakov, O, Goretti, A, Granato, F, Grassi, M, Grate, J, Grigoriev, G, Gromov, M, Guan, M, Guerra, M, Guerzoni, M, Gulino, M, Haaland, R, Hallin, A, Harrop, B, Hoppe, E, Horikawa, S, Hosseini, B, Hughes, D, Humble, P, Hungerford, E, Ianni, A, Jillings, C, Johnson, T, Keeter, K, Kendziora, C, Kim, S, Koh, G, Korablev, D, Korga, G, Kubankin, A, Kuss, M, Kúzniak, M, La Commara, M, Lehnert, B, Li, X, Lissia, M, Lodi, G, Loer, B, Longo, G, Loverre, P, Lussana, R, Luzzi, L, Ma, Y, Machado, A, Machulin, I, Mandarano, A, Mapelli, L, Marcante, M, Margotti, A, Mari, S, Mariani, M, Maricic, J, Martoff, C, Mascia, M, Mayer, M, Mcdonald, A, Messina, A, Meyers, P, Milincic, R, Moggi, A, Moioli, S, Monroe, J, Monte, A, Morrocchi, M, Mount, B, Mu, W, Muratova, V, Murphy, S, Musico, P, Nania, R, Navrer Agasson, A, Nikulin, I, Nosov, V, Nozdrina, A, Nurakhov, N, Oleinik, A, Oleynikov, V, Orsini, M, Ortica, F, Pagani, L, Pallavicini, M, Palmas, S, Pandola, L, Pantic, E, Paoloni, E, Paternoster, G, Pavletcov, V, Pazzona, F, Peeters, S, Pelczar, K, Pellegrini, L, Pelliccia, N, Perotti, F, Perruzza, R, Pesudo, V, Piemonte, C, Pilo, F, Pocar, A, Pollmann, T, Portaluppi, D, Pugachev, D, Qian, H, Radics, B, Raffaelli, F, Ragusa, F, Razeti, M, Razeto, A, Regazzoni, V, Regenfus, C, Reinhold, B, Renshaw, A, Rescigno, M, Retière, F, Riffard, Q, Rivetti, A, Rizzardini, S, Romani, A, Romero, L, Rossi, B, Rossi, N, Rubbia, A, Sablone, D, Salatino, P, Samoylov, O, Sánchez García, E, Sands, W, Sanfilippo, S, Sant, M, Santorelli, R, Savarese, C, Scapparone, E, Schlitzer, B, Scioli, G, Segreto, E, Seifert, A, Semenov, D, Shchagin, A, Shekhtman, L, Shemyakina, E, Sheshukov, A, Simeone, M, Singh, P, Skensved, P, Skorokhvatov, M, Smirnov, O, Sobrero, G, Sokolov, A, Sotnikov, A, Speziale, F, Stainforth, R, Stanford, C, Suffritti, G, Suvorov, Y, Tartaglia, R, Testera, G, Tonazzo, A, Tosi, A, Trinchese, P, Unzhakov, E, Vacca, A, Vázquez-Jáuregui, E, Verducci, M, Viant, T, Villa, F, Vishneva, A, Vogelaar, B, Wada, M, Wahl, J, Walding, J, Wang, H, Wang, Y, Watson, A, Westerdale, S, Williams, R, Wojcik, M, Wu, S, Xiang, X, Xiao, X, Yang, C, Ye, Z, Yllera de Llano, A, Zappa, F, Zappalà, G, Zhu, C, Zichichi, A, Zullo, M, Zullo, A, Zuzel, G, University of Naples Federico II = Università degli studi di Napoli Federico II, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Pavia = University of Pavia (UNIPV), Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), École normale supérieure - Paris (ENS-PSL), Laboratoire de Biologie du Développement (LBD), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Kúzniak, M., Trinchese, Pasquale, Aalseth, C.E., Albuquerque, I.F.M., Alton, A.K., Arnquist, I.J., Asner, D.M., Back, H.O., Barrado Olmedo, A.I., Bisogni, M.G., Cocco, A.G., Da Rocha Rolo, M.D., Froudakis, G.E., Giorgi, M.A., Giovanetti, G.K., Gligan, M.L., Goretti, A.M., Grate, J.W., Grigoriev, G.Y., Guerra, M.B.B., Haaland, R.K., Hoppe, E.W., Hungerford, E.V., Johnson, T.N., Kendziora, C.L., Lodi, G.U., Machado, A.A., Machulin, I.N., Mari, S.M., Martoff, C.J., McDonald, A.B., Meyers, P.D., Mount, B.J., Muratova, V.N., Nozdrina, A.O., Nurakhov, N.N., Pellegrini, L.A., Pugachev, D.A., Renshaw, A.L., Semenov, D.A., Singh, P.N., Skorokhvatov, M.D., Suffritti, G.B., Unzhakov, E.V., Watson, A.W., Wojcik, M.M., Unité de Catalyse et Chimie du Solide - Equipes du Site Artois (UCCS Artois), Unité de Catalyse et Chimie du Solide - UMR 8181 (UCCS), Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Lille (ENSCL)-Ecole Centrale de Lille-Université d'Artois (UA)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Lille (ENSCL)-Ecole Centrale de Lille-Université d'Artois (UA), Universidade Nova de Lisboa = NOVA University of Lisboa (NOVA)-Universidade Nova de Lisboa = NOVA University of Lisboa (NOVA)-Faculdade de Ciências e Tecnologia (FCT NOVA), and Universidade Nova de Lisboa = NOVA University of Lisboa (NOVA)-Universidade Nova de Lisboa = NOVA University of Lisboa (NOVA)

Subjects
Particle physics, VAPOR-PRESSURE, Physics - Instrumentation and Detectors, Solar neutrino, Dark matter, General Physics and Astronomy, FOS: Physical sciences, Scintillator, SCINTILLATION EFFICIENCY, 01 natural sciences, PROPERTIES, Nuclear physics, Physics and Astronomy (all), Silicon photomultiplier, WIMP, LIQUID-ARGON, RADIOACTIVITY, DESIGN, SEARCH, 0103 physical sciences, ISOTOPIC LIQUIDS, 010306 general physics, Cherenkov radiation, ComputingMilieux_MISCELLANEOUS, Physics, [PHYS]Physics [physics], Time projection chamber, 010308 nuclear & particles physics, Detector, Instrumentation and Detectors (physics.ins-det), MODEL, THERMODYNAMIC, IONIZATION, Dark Matter – WIMP – Nobel Liquid Detector – Low-background Detectors – Liquid Scintillator – SiPM – Silicon Photomultiplier – Underground Argon – Low-radioactivity Argon, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract

Building on the successful experience in operating the DarkSide-50 detector, the DarkSide Collaboration is going to construct DarkSide-20k, a direct WIMP search detector using a two-phase Liquid Argon Time Projection Chamber (LAr TPC) with an active (fiducial) mass of 23 t (20 t). This paper describes a preliminary design for the experiment, in which the DarkSide-20k LAr TPC is deployed within a shield/veto with a spherical Liquid Scintillator Veto (LSV) inside a cylindrical Water Cherenkov Veto (WCV). This preliminary design provides a baseline for the experiment to achieve its physics goals, while further development work will lead to the final optimization of the detector parameters and an eventual technical design. Operation of DarkSide-50 demonstrated a major reduction in the dominant 39Ar background when using argon extracted from an underground source, before applying pulse shape analysis. Data from DarkSide-50, in combination with MC simulation and analytical modeling, shows that a rejection factor for discrimination between electron and nuclear recoils of $>3 \times 10^{9}$ is achievable. This, along with the use of the veto system and utilizing silicon photomultipliers in the LAr TPC, are the keys to unlocking the path to large LAr TPC detector masses, while maintaining an experiment in which less than $< 0.1$ events (other than $\nu$ -induced nuclear recoils) is expected to occur within the WIMP search region during the planned exposure. DarkSide-20k will have ultra-low backgrounds than can be measured in situ, giving sensitivity to WIMP-nucleon cross sections of $1.2 \times 10^{-47}$ cm2 ( $1.1 \times 10^{-46}$ cm2) for WIMPs of 1 TeV/c2 (10 TeV/c2) mass, to be achieved during a 5 yr run producing an exposure of 100 t yr free from any instrumental background.

Published
2018

36. Cryogenic Characterization of FBK RGB-HD SiPMs

Author

C. E. Aalseth, F. Acerbi, P. Agnes, I. F. M. Albuquerque, T. Alexander, A. Alici, A. K. Alton, P. Ampudia, P. Antonioli, S. Arcelli, R. Ardito, I. J. Arnquist, D. M. Asner, H. O. Back, G. Batignani, E. Bertoldo, S. Bettarini, M. G. Bisogni, V. Bocci, A. Bondar, G. Bonfini, W. Bonivento, M. Bossa, B. Bottino, R. Bunker, S. Bussino, A. Buzulutskov, M. Cadeddu, M. Cadoni, A. Caminata, N. Canci, A. Candela, C. Cantini, M. Caravati, M. Cariello, M. Carlini, M. Carpinelli, A. Castellani, S. Catalanotti, V. Cataudella, P. Cavalcante, R. Cereseto, Y. Chen, A. Chepurnov, A. Chiavassa, C. Cicalò, L. Cifarelli, M. Citterio, A. G. Cocco, M. Colocci, S. Corgiolu, G. Covone, P. Crivelli, I. D'Antone, M. D'Incecco, M. D. Da Rocha Rolo, M. Daniel, S. Davini, A. De Candia, S. De Cecco, M. De Deo, G. De Filippis, G. De Guido, G. De Rosa, G. Dellacasa, P. Demontis, A. V. Derbin, A. Devoto, F. Di Eusanio, G. Di Pietro, C. Dionisi, A. Dolgov, I. Dormia, S. Dussoni, A. Empl, A. Ferri, C. Filip, G. Fiorillo, K. Fomenko, D. Franco, G. E. Froudakis, F. Gabriele, A. Gabrieli, C. Galbiati, P. Garcia Abia, A. Gendotti, A. Ghisi, S. Giagu, G. Gibertoni, C. Giganti, M. Giorgi, G. K. Giovanetti, M. L. Gligan, A. Gola, O. Gorchakov, A. M. Goretti, F. Granato, M. Grassi, J. W. Grate, G. Y. Grigoriev, M. Gromov, M. Guan, M. B. B. Guerra, M. Guerzoni, M. Gulino, R. K. Haaland, B. Harrop, E. W. Hoppe, S. Horikawa, B. Hosseini, D. Hughes, P. Humble, E. V. Hungerford, An. Ianni, S. Jimenez Cabre, T. N. Johnson, K. Keeter, C. L. Kendziora, S. Kim, G. Koh, D. Korablev, G. Korga, A. Kubankin, R. Kugathasan, M. Kuss, X. Li, M. Lissia, G. U. Lodi, B. Loer, G. Longo, R. Lussana, L. Luzzi, Y. Ma, A. A. Machado, I. N. Machulin, L. Mais, A. Mandarano, L. Mapelli, M. Marcante, A. Margotti, S. M. Mari, M. Mariani, J. Maricic, M. Marinelli, D. Marras, C. J. Martoff, M. Mascia, A. Messina, P. D. Meyers, R. Milincic, A. Moggi, S. Moioli, S. Monasterio, J. Monroe, A. Monte, M. Morrocchi, W. Mu, V. N. Muratova, S. Murphy, P. Musico, R. Nania, J. Napolitano, A. Navrer Agasson, I. Nikulin, V. Nosov, A. O. Nozdrina, N. N. Nurakhov, A. Oleinik, V. Oleynikov, M. Orsini, F. Ortica, L. Pagani, M. Pallavicini, S. Palmas, L. Pandola, E. Pantic, E. Paoloni, G. Paternoster, V. Pavletcov, F. Pazzona, K. Pelczar, L. A. Pellegrini, N. Pelliccia, F. Perotti, R. Perruzza, C. Piemonte, F. Pilo, A. Pocar, D. Portaluppi, S. S. Poudel, D. A. Pugachev, H. Qian, B. Radics, F. Raffaelli, F. Ragusa, K. Randle, M. Razeti, A. Razeto, V. Regazzoni, C. Regenfus, B. Reinhold, A. L. Renshaw, M. Rescigno, Q. Riffard, A. Rivetti, A. Romani, L. Romero, B. Rossi, N. Rossi, A. Rubbia, D. Sablone, P. Salatino, O. Samoylov, W. Sands, M. Sant, R. Santorelli, C. Savarese, E. Scapparone, B. Schlitzer, G. Scioli, E. Sechi, E. Segreto, A. Seifert, D. A. Semenov, S. Serci, A. Shchagin, L. Shekhtman, E. Shemyakina, A. Sheshukov, M. Simeone, P. N. Singh, M. D. Skorokhvatov, O. Smirnov, G. Sobrero, A. Sokolov, A. Sotnikov, C. Stanford, G. B. Suffritti, Y. Suvorov, R. Tartaglia, G. Testera, A. Tonazzo, A. Tosi, P. Trinchese, E. V. Unzhakov, A. Vacca, M. Verducci, T. Viant, F. Villa, A. Vishneva, B. Vogelaar, M. Wada, J. Wahl, S. Walker, H. Wang, Y. Wang, A. W. Watson, S. Westerdale, J. Wilhelmi, R. Williams, M. M. Wojcik, S. Wu, X. Xiang, X. Xiao, C. Yang, Z. Ye, F. Zappa, G. Zappalà, C. Zhu, A. Zichichi, G. Zuzel, Aalseth, C. E., Acerbi, F., Agnes, P., Albuquerque, I. F. M., Alexander, T., Alici, A., Alton, A. K., Ampudia, P., Antonioli, P., Arcelli, S., Ardito, R., Arnquist, I. J., Asner, D. M., Back, H. O., Batignani, G., Bertoldo, E., Bettarini, S., Bisogni, M. G., Bocci, V., Bondar, A., Bonfini, G., Bonivento, W., Bossa, M., Bottino, B., Bunker, R., Bussino, S., Buzulutskov, A., Cadeddu, M., Cadoni, M., Caminata, A., Canci, N., Candela, A., Cantini, C., Caravati, M., Cariello, M., Carlini, M., Carpinelli, M., Castellani, A., Catalanotti, S., Cataudella, V., Cavalcante, P., Cereseto, R., Chen, Y., Chepurnov, A., Chiavassa, A., Cicalò, C., Cifarelli, L., Citterio, M., Cocco, A. G., Colocci, M., Corgiolu, S., Covone, G., Crivelli, P., D'Antone, I., D'Incecco, M., Rolo, M. D. Da Rocha, Daniel, M., Davini, S., Candia, A. De, Cecco, S. De, Deo, M. De, Filippis, G. De, De Guido, Giorgia, De Rosa, Gianfranca, Dellacasa, G., Demontis, P., Derbin, A. V., Devoto, A., Eusanio, F. Di, Pietro, G. Di, Dionisi, C., Dolgov, A., Dormia, I., Dussoni, S., Empl, A., Ferri, A., Filip, C., Fiorillo, G., Fomenko, K., Franco, D., Froudakis, G. E., Gabriele, F., Gabrieli, A., Galbiati, C., Abia, P. Garcia, Gendotti, A., Ghisi, A., Giagu, S., Gibertoni, G., Giganti, C., Giorgi, M., Giovanetti, G. K., Gligan, M. L., Gola, A., Gorchakov, O., Goretti, A. M., Granato, F., Grassi, M., Grate, J. W., Grigoriev, G. Y., Gromov, M., Guan, M., Guerra, M. B. B., Guerzoni, M., Gulino, M., Haaland, R. K., Harrop, B., Hoppe, E. W., Horikawa, S., Hosseini, B., Hughes, D., Humble, P., Hungerford, E. V., Ianni, An., Cabre, S. Jimenez, Johnson, T. N., Keeter, K., Kendziora, C. L., Kim, S., Koh, G., Korablev, D., Korga, G., Kubankin, A., Kugathasan, R., Kuss, M., Li, X., Lissia, M., Lodi, G. U., Loer, B., Longo, G., Lussana, R., Luzzi, L., Ma, Y., Machado, A. A., Machulin, I. N., Mais, L., Mandarano, A., Mapelli, L., Marcante, M., Margotti, A., Mari, S. M., Mariani, M., Maricic, J., Marinelli, M., Marras, D., Martoff, C. J., Mascia, M., Messina, A., Meyers, P. D., Milincic, R., Moggi, A., Moioli, S., Monasterio, S., Monroe, J., Monte, A., Morrocchi, M., Mu, W., Muratova, V. N., Murphy, S., Musico, P., Nania, R., Napolitano, J., Agasson, A. Navrer, Nikulin, I., Nosov, V., Nozdrina, A. O., Nurakhov, N. N., Oleinik, A., Oleynikov, V., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Palmas, S., Pandola, L., Pantic, E., Paoloni, E., Paternoster, G., Pavletcov, V., Pazzona, F., Pelczar, K., Pellegrini, L. A., Pelliccia, N., Perotti, F., Perruzza, R., Piemonte, C., Pilo, F., Pocar, A., Portaluppi, D., Poudel, S. S., Pugachev, D. A., Qian, H., Radics, B., Raffaelli, F., Ragusa, F., Randle, K., Razeti, M., Razeto, A., Regazzoni, V., Regenfus, C., Reinhold, B., Renshaw, A. L., Rescigno, M., Riffard, Q., Rivetti, A., Romani, A., Romero, L., Rossi, B., Rossi, N., Rubbia, A., Sablone, D., Salatino, P., Samoylov, O., Sands, W., Sant, M., Santorelli, R., Savarese, C., Scapparone, E., Schlitzer, B., Scioli, G., Sechi, E., Segreto, E., Seifert, A., Semenov, D. A., Serci, S., Shchagin, A., Shekhtman, L., Shemyakina, E., Sheshukov, A., Simeone, M., Singh, P. N., Skorokhvatov, M. D., Smirnov, O., Sobrero, G., Sokolov, A., Sotnikov, A., Stanford, C., Suffritti, G. B., Suvorov, Y., Tartaglia, R., Testera, G., Tonazzo, A., Tosi, A., Trinchese, P., Unzhakov, E. V., Vacca, A., Verducci, M., Viant, T., Villa, F., Vishneva, A., Vogelaar, B., Wada, M., Wahl, J., Walker, S., Wang, H., Wang, Y., Watson, A. W., Westerdale, S., Wilhelmi, J., Williams, R., Wojcik, M. M., Wu, S., Xiang, X., Xiao, X., Yang, C., Ye, Z., Zappa, F., Zappalà, G., Zhu, C., Zichichi, A., Zuzel, G., AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), DarkSide, Aalseth, C, Acerbi, F, Agnes, P, Albuquerque, I, Alexander, T, Alici, A, Alton, A, Ampudia, P, Antonioli, P, Arcelli, S, Ardito, R, Arnquist, I, Asner, D, Back, H, Batignani, G, Bertoldo, E, Bettarini, S, Bisogni, M, Bocci, V, Bondar, A, Bonfini, G, Bonivento, W, Bossa, M, Bottino, B, Bunker, R, Bussino, S, Buzulutskov, A, Cadeddu, M, Cadoni, M, Caminata, A, Canci, N, Candela, A, Cantini, C, Caravati, M, Cariello, M, Carlini, M, Carpinelli, M, Castellani, A, Catalanotti, S, Cataudella, V, Cavalcante, P, Cereseto, R, Chen, Y, Chepurnov, A, Chiavassa, A, Cicalò, C, Cifarelli, L, Citterio, M, Cocco, A, Colocci, M, Corgiolu, S, Covone, G, Crivelli, P, D'Antone, I, D'Incecco, M, Rolo, M, Daniel, M, Davini, S, Candia, A, Cecco, S, Deo, M, Filippis, G, Guido, G, Rosa, G, Dellacasa, G, Demontis, P, Derbin, A, Devoto, A, Eusanio, F, Pietro, G, Dionisi, C, Dolgov, A, Dormia, I, Dussoni, S, Empl, A, Ferri, A, Filip, C, Fiorillo, G, Fomenko, K, Franco, D, Froudakis, G, Gabriele, F, Gabrieli, A, Galbiati, C, Abia, P, Gendotti, A, Ghisi, A, Giagu, S, Gibertoni, G, Giganti, C, Giorgi, M, Giovanetti, G, Gligan, M, Gola, A, Gorchakov, O, Goretti, A, Granato, F, Grassi, M, Grate, J, Grigoriev, G, Gromov, M, Guan, M, Guerra, M, Guerzoni, M, Gulino, M, Haaland, R, Harrop, B, Hoppe, E, Horikawa, S, Hosseini, B, Hughes, D, Humble, P, Hungerford, E, Ianni, A, Cabre, S, Johnson, T, Keeter, K, Kendziora, C, Kim, S, Koh, G, Korablev, D, Korga, G, Kubankin, A, Kugathasan, R, Kuss, M, Li, X, Lissia, M, Lodi, G, Loer, B, Longo, G, Lussana, R, Luzzi, L, Ma, Y, Machado, A, Machulin, I, Mais, L, Mandarano, A, Mapelli, L, Marcante, M, Margotti, A, Mari, S, Mariani, M, Maricic, J, Marinelli, M, Marras, D, Martoff, C, Mascia, M, Messina, A, Meyers, P, Milincic, R, Moggi, A, Moioli, S, Monasterio, S, Monroe, J, Monte, A, Morrocchi, M, Mu, W, Muratova, V, Murphy, S, Musico, P, Nania, R, Napolitano, J, Agasson, A, Nikulin, I, Nosov, V, Nozdrina, A, Nurakhov, N, Oleinik, A, Oleynikov, V, Orsini, M, Ortica, F, Pagani, L, Pallavicini, M, Palmas, S, Pandola, L, Pantic, E, Paoloni, E, Paternoster, G, Pavletcov, V, Pazzona, F, Pelczar, K, Pellegrini, L, Pelliccia, N, Perotti, F, Perruzza, R, Piemonte, C, Pilo, F, Pocar, A, Portaluppi, D, Poudel, S, Pugachev, D, Qian, H, Radics, B, Raffaelli, F, Ragusa, F, Randle, K, Razeti, M, Razeto, A, Regazzoni, V, Regenfus, C, Reinhold, B, Renshaw, A, Rescigno, M, Riffard, Q, Rivetti, A, Romani, A, Romero, L, Rossi, B, Rossi, N, Rubbia, A, Sablone, D, Salatino, P, Samoylov, O, Sands, W, Sant, M, Santorelli, R, Savarese, C, Scapparone, E, Schlitzer, B, Scioli, G, Sechi, E, Segreto, E, Seifert, A, Semenov, D, Serci, S, Shchagin, A, Shekhtman, L, Shemyakina, E, Sheshukov, A, Simeone, M, Singh, P, Skorokhvatov, M, Smirnov, O, Sobrero, G, Sokolov, A, Sotnikov, A, Stanford, C, Suffritti, G, Suvorov, Y, Tartaglia, R, Testera, G, Tonazzo, A, Tosi, A, Trinchese, P, Unzhakov, E, Vacca, A, Verducci, M, Viant, T, Villa, F, Vishneva, A, Vogelaar, B, Wada, M, Wahl, J, Walker, S, Wang, H, Wang, Y, Watson, A, Westerdale, S, Wilhelmi, J, Williams, R, Wojcik, M, Wu, S, Xiang, X, Xiao, X, Yang, C, Ye, Z, Zappa, F, Zappalà, G, Zhu, C, Zichichi, A, Zuzel, G, Bussino, Severino Angelo Maria, Da Rocha Rolo, M. D., De Candia, A., De Cecco, S., De Deo, M., De Filippis, G., De Guido, G., De Rosa, G., Di Eusanio, F., Di Pietro, G., Garcia Abia, P., Ianni, A. n., Jimenez Cabre, S., Mari, Stefano Maria, Navrer Agasson, A., Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Cicalã², C., G. De, Filippi, Guido, G. De, G. De, Rosa, and Zappalã , G.

Subjects
visible and IR photons, Physics - Instrumentation and Detectors, data acquisition, SiPMs, 1ST PROTOTYPES, 01 natural sciences, Photon detectors forUV, visible and IR photons (solid-state) (PIN diodes, APDs, Si-PMTs, G-APDs, CCDs, EBCCDs, EMCCDs etc), etc), Data acquisition, EMCCDs etc), APDs, Photon detectors for UV, visible and IR photons (solid-state), Instrumentation, Mathematical Physics, Physics, EBCCDs, Si-PMTs, Instrumentation and Detectors (physics.ins-det), Cryogenic detectors, Photon detectors for UV, visible and IR photons (solid-state), G-APDs, Physics - Instrumentation and Detector, performance, Dark current, noise, ionization: yield, Dark matter, quenching, High density, Cryogenic detector, FOS: Physical sciences, DarkSide, Noise (electronics), programming, Optics, 0103 physical sciences, Analysis software, photomultiplier: silicon, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], (solid-state) (PIN diodes, visible and IR photons (solid-state) (PIN diodes, 010306 general physics, SILICON, 010308 nuclear & particles physics, business.industry, CCDs, dark matter: detector, ITC-IRST, (solid-state) (PIN diodes, APDs, Si-PMTs, G-APDs, CCDs, EBCCDs, EMCCDs, time projection chamber: liquid argon, (solid-state), Photon detectors forUV, EMCCDs, RGB color model, business
Abstract

International audience; We report on the cryogenic characterization of Red Green Blue - High Density (RGB-HD) SiPMs developed at Fondazione Bruno Kessler (FBK) as part of the DarkSide program of dark matter searches with liquid argon time projection chambers. A cryogenic setup was used to operate the SiPMs at varying temperatures and a custom data acquisition system and analysis software were used to precisely characterize the primary dark noise, the correlated noise, and the gain of the devices. We demonstrate that FBK RGB-HD SiPMs with low quenching resistance (RGB-HD-LRq) can be operated from 40 K to 300 K with gains in the range 10(5) to 10(6) and noise rates at a level of around 1 Hz/mm(2).

Published
2017

37. EULAR recommendations for the treatment of systemic sclerosis: 2023 update.

Author

Del Galdo F, Lescoat A, Conaghan PG, Bertoldo E, Čolić J, Santiago T, Suliman YA, Matucci-Cerinic M, Gabrielli A, Distler O, Hoffmann-Vold AM, Castellví I, Balbir-Gurman A, Vonk M, Ananyeva L, Rednic S, Tarasova A, Ostojic P, Boyadzhieva V, El Aoufy K, Farrington S, Galetti I, Denton CP, Kowal-Bielecka O, Mueller-Ladner U, and Allanore Y

Abstract

Objectives: To update the 2017 European Alliance of Associations for Rheumatology (EULAR) recommendations for treatment of systemic sclerosis (SSc), incorporating new evidence and therapies., Methods: An international task force was convened in line with EULAR standard operating procedures. A nominal group technique exercise was performed in two rounds to define questions underpinning a subsequent systematic literature review. The evidence derived was discussed and overarching principles, recommendations and future research agenda were iteratively developed with voting rounds., Results: The task force agreed on 22 recommendations covering 8 clinical/organ domains including Raynaud's phenomenon, digital ulcers, pulmonary arterial hypertension, scleroderma renal crisis, skin fibrosis, interstitial lung disease (ILD), gastrointestinal manifestations and arthritis. Most new recommendations are related to skin fibrosis and ILD. These included novel recommendations for the use of mycophenolate mofetil, nintedanib, rituximab and tocilizumab for the treatment of these crucial disease manifestations. The recommendations also included first-line and second-line interventions, providing increased utility for rheumatology practitioners. Important additions to the future research agenda included consideration of novel interventions for the management of vascular, musculoskeletal and gastrointestinal manifestations and calcinosis, as well as for the local management of digital ulcers., Conclusion: These updated recommendations include the first set of synthetic and biological targeted therapies recommended for key fibrotic manifestations of SSc as well as first-line combination treatment for newly diagnosed pulmonary artery hypertension and prioritise a new research agenda for the coming years., Competing Interests: Competing interests: Each author has signed a detailed ICMJE sent as online supplemental file 2., (© European Alliance of Associations for Rheumatology, EULAR 2024. Re-use permitted under CC BY-NC-ND. No commercial re-use. No derivatives. See rights and permissions. Published by BMJ on behalf of EULAR.)

Published
2024
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38. Expanding the VEXAS diagnostic workup: the role of peripheral blood cytological analysis.

Author

Baggio C, Oliviero F, Padoan R, Iorio L, Bixio R, Orsolini G, Bertoldo E, Bernardi C, Colavito D, Paiero B, Pregnolato G, Ramonda R, Doria A, Bindoli S, and Sfriso P

Subjects
Humans, Male, Female, Middle Aged, Adult, Aged, Young Adult, Hereditary Autoinflammatory Diseases diagnosis, Hereditary Autoinflammatory Diseases genetics, Hereditary Autoinflammatory Diseases pathology, Mutation, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis diagnosis, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis pathology, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis blood, Leukocytes, Ubiquitin-Activating Enzymes, Cytokines metabolism, Cytokines blood
Abstract

VEXAS syndrome is a newly described autoinflammatory entity characterized by somatic mutations in the UBA1 X-linked gene in hematopoietic progenitor cells. Several studies have demonstrated that the presence of vacuoles in progenitor cells from bone marrow aspirates is a hallmark finding for this syndrome. Therefore, this study aimed to characterize leukocytes from VEXAS patients versus patients with ANCA-associated vasculitis (AAV), familial Mediterranean fever (FMF), and healthy donors (HD) to define a specific cytological pattern that can support VEXAS diagnosis. Twelve VEXAS patients were included in the study. Blood samples from FMF (n = 16), AAV (n = 16) and HDs (n = 20) acted as controls. May-Grünwald Giemsa (MGG) staining was used for studying cellular morphology, including cytoplasm, granules, and vacuoles and to perform a cytogenic evaluation of leucocytes. Plasma IL-1β, IL-1α, TNFα, IL-18 and IL-8 were measured using ELISA assay. The cytological analysis from blood smears confirmed the presence of immature neutrophils in VEXAS patients. We found a greater number of vacuoles in VEXAS patients vs. FMF, AAV and HD. Micronuclei (MNi) and cell death rate were higher in VEXAS patients vs. HD. Cell death correlated with IL-1β and IL-8 levels. MNi were positively associated with IL-8 and IL-1β levels, and with the percentage of immature neutrophils and vacuoles. In conclusion, our findings suggested that cytological test may be supportive for VEXAS diagnosis, despite genetical analysis is mandatory for confirming the disease. Finally, we identified several cytological hallmarks that may distinguish the VEXAS "cytotype" not only from HD but also from other inflammatory diseases., Competing Interests: AD received consultancy fees from GSK, Eli Lilly, AstraZeneca, Otsuka. PS received grants from Novartis and Sobi. Authors DC, BP and GP were employed by R&I Genetics srl. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision., (Copyright © 2024 Baggio, Oliviero, Padoan, Iorio, Bixio, Orsolini, Bertoldo, Bernardi, Colavito, Paiero, Pregnolato, Ramonda, Doria, Bindoli and Sfriso.)

Published
2024
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39. The role of 18 FDG-PET imaging in VEXAS syndrome: a multicentric case series and a systematic review of the literature.

Author

Bixio R, Bindoli S, Morciano A, Padoan R, Aldegheri F, Mastropaolo F, Bertoldo E, Rotta D, Appoloni M, Orsolini G, Gatti D, Adami G, Viapiana O, Rossini M, Sfriso P, and Fassio A

Abstract

VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, and somatic) syndrome is characterized by heterogeneous clinical manifestations. Due to the inflammatory nature of this condition, 18-FDG-PET (18-fluorodeoxyglucose-positron emission tomography) might be used to diagnose and monitor the disease. However, no data are available about the most common findings of PET imaging in this disease. For this reason, we summarised all the available reports of patients with VEXAS who underwent at least one PET scan and described 8 additional patients' PET from our centres. Overall, we described 35 patients' PET findings. All patients were male, with a median age of 70 years. The most frequent hypermetabolic sites on PET scans were the bone marrow (77.1%), lymph nodes (35.3%), lungs (28.6%), spleen and large vessels (22.9%), and cartilage (20%). Six patients underwent a PET scan 2.7 ± 1.5 years before VEXAS diagnosis, showing nonspecific uptake in the bone marrow. Four patients had a follow-up PET scan, showing a decrease or a disappearance of the previously identified hypermetabolic areas. In conclusion, although no specific uptake site has been found for VEXAS syndrome, PET imaging could help detect inflammatory foci that are not clinically evident. In addition, high metabolic activity in bone marrow might precede the clinical onset of the disease, shedding light on the pathogenesis of VEXAS., (© 2024. The Author(s).)

Published
2024
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40. The potential pathogenic role of gut microbiota in rheumatic diseases: a human-centred narrative review.

Author

Bixio R, Bertelle D, Bertoldo E, Morciano A, and Rossini M

Subjects
Humans, Arthritis, Rheumatoid microbiology, Gastrointestinal Microbiome physiology, Rheumatic Diseases microbiology
Abstract

A growing amount of evidence suggests that gut microbiota plays an important role in human health, including a possible role in the pathogenesis of rheumatic and musculoskeletal diseases (RMD). We analysed the current evidence about the role of microbiota in rheumatoid arthritis (RA), spondyloarthritis (SpA), systemic lupus erythematosus (SLE) and systemic sclerosis (SSc). In RA, we found a general consensus regarding a reduction of diversity and a specific bacterial signature, with consistent changes according to the different ethnic and geographical areas. The major pathogenetic role in RA is recognised for P. copri, L. salivarius and Collinsella, even if findings become more heterogeneous when considering established disease. In SpA, we found a relative gut abundance of Akkermansia, Coprococcus, Ruminoccocus and a relative reduction in Bacterioides and Firmicutes spp. Human and preclinical data suggest loss of mucosal barrier, increased permeability and Th1- and Th17-mediated inflammation. Additionally, HLA-B27 seems to play a role in shaping the intestinal microbiota and the consequent inflammation. In SLE, the typical gut microbiota signature was characterised by a reduction in the Firmicutes/Bacteroidetes ratio and by enrichment of Rhodococcus, Eggerthella, Klebsiella, Prevotella, Eubacterium and Flavonifractor, even if their real pathogenic impact remains unclear. In SSc, gastrointestinal dysbiosis is well documented with an increase of pro-inflammatory species (Fusobacterium, Prevotella, Ruminococcus, Akkermansia, γ-Proteobacteria, Erwinia, Trabsulsiella, Bifidobacterium, Lactobacillus, Firmicutes and Actinobacteria) and a reduction of species as Faecalibacterium, Clostridium, Bacteroidetes and Rikenella. In conclusion, seems possible to recognise a distinct gut microbiota profile for each RMD, even if significant differences in bacterial species do exist between different studies and there is a high risk of bias due to the cross-sectional nature of such studies. Therefore longitudinal studies are needed, especially on patients with preclinical and early disease, to investigate the real role of gut microbiota in the pathogenesis of RMD., (© 2023. The Author(s), under exclusive licence to Società Italiana di Medicina Interna (SIMI).)

Published
2024
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41. JAK inhibitors for the treatment of VEXAS syndrome.

Author

Bindoli S, Baggio C, Doria A, Bertoldo E, and Sfriso P

Subjects
Male, Humans, Aged, Genes, X-Linked, Hematopoietic Stem Cells, Mutation, Janus Kinase Inhibitors therapeutic use, Myelodysplastic Syndromes
Abstract

Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome is a novel described autoinflammatory entity for which the diagnosis is defined by somatic mutations of the UBA1 X-linked gene in hematopoietic progenitor cells. The clinical manifestations are heterogeneous since they range from autoinflammatory symptoms to the presence of underlying hematologic disorders such as myelodysplastic syndromes. Response to treatment in VEXAS is very poor and to date, the therapeutic strategies adopted are only partially effective. However, recently described cohorts of subjects with VEXAS treated with Janus kinase inhibitors (JAK-I) proved that these drugs can be effective in the treatment of several manifestations related to the disease. Herein, we carried out a brief literature review that includes cohorts and single cases in which JAK-I were adopted as a promising strategy to manage VEXAS patients. Subsequently, we described our experience with JAK-I in VEXAS, illustrating the first case, to our knowledge, of a 65-year-old man who was successfully treated with the selective JAK-1 inhibitor filgotinib.

Published
2023
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42. Higher body mass index is associated with a lower iloprost infusion rate tolerance and higher iloprost-related adverse events in patients with systemic sclerosis.

Author

Bixio R, Adami G, Bertoldo E, Giollo A, Morciano A, Bertelle D, Orsolini G, Idolazzi L, Rossini M, and Viapiana O

Abstract

Background: Systemic sclerosis (SSc) is an autoimmune disease characterized by vasospasm and microvascular involvement. Iloprost (ILO), a prostaglandin analogous, is used for the treatment of SSc-related Raynaud's phenomenon and digital ulcers. The suggested dose is 0.5-2 ng/kg/min for 6-8 h, and the maximum dose is decided upon the patient's tolerance., Objectives: This study aims to analyze ILO infusion tolerance and possible predictive factors in patients with SSc., Design: This is a retrospective observational study., Method: We evaluated 113 patients with SSc beginning ILO intravenous (IV) infusion treatment between 2004 and 2021. We assessed the maximum tolerated ILO IV infusion rate, the incidence of adverse events (AEs), and the need for symptomatic therapy during the dose-finding sessions. We collected relevant demographic and medical and employed generalized linear models to assess possible predictors of maximum tolerated ILO infusion rate and AEs and logistic regression to assess predictors of AEs., Results: The median ILO infusion rate at the end of the dose-finding process was 0.88 ng/kg/min [interquartile range (IQR) = 0.37]. We found a significant inverse correlation between ILO infusion rate and body mass index (BMI) at the beginning of treatment. BMI was negatively associated with ILO infusion rate ( β  = -0.21, p  = 0.02) after correction for relevant confounding factors. Overweight patients (BMI >26) presented a 13-fold increased risk of developing AEs during ILO titration [adjusted odds ratio = 13.979, 95% confidence interval (CI) = 2.359-82.845]. AEs during ILO titration occurred in 47.8% of patients, of whom 22.2% presented hypotension. Other AEs were headache, nausea, vomiting, diarrhea, and edema. Symptomatic therapy was needed in half of the patients at least once., Conclusion: This study showed that higher BMI was statistically associated with lower ILO infusion rate tolerance and higher AEs rate, underlying a possible BMI-dependent endothelial dysfunction. Individual ILO regimens still need to be tailored to the patient., Plain Language Summary: Introduction: Systemic sclerosis is a rare a rheumatic disease characterized by skin thickening, vasospasm, and digital ulcers (DUs), as well as other organs involvement. Iloprost, which is administered as intravenous infusion, is one of the main treatments for this disease, and it is effective in reducing vasospasm and the frequency of DUs. Even if there is a suggested dose range, the exact dose must be tailored on each patient, because the tolerance to the drug is variable. Tolerance is limited by dose-dependent unwanted effects, as headache, low blood pressure, dizziness, and sickness. This study aimed to identify possible predictors of such tolerance. Materials and Methods: We collected data from our patients with systemic sclerosis beginning the treatment with iloprost between January 2004 and November 2021 at our hospital facility in Verona, Italy, and analyzed different factors that could be associated with a better tolerance, as age, sex, disease duration, smoking habit, body mass index (a measure of body fatness), blood pressure, concomitant medications, and different patterns of the disease. Results: We found that a higher body mass index was associated with lower iloprost tolerance and higher adverse events rate in patients with systemic sclerosis, while we did not find a correlation with other factors. We believe overweight and obese patients (who have a higher body mass index) have a defect in the vasodilatation mechanism and can therefore be more susceptible to the effect of this medication. Conclusions: While preliminary, our results could provide a good starting point to develop a predictive tool to limit adverse events during this therapy., Competing Interests: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. The Associate Editor of Therapeutic Advances in Musculoskeletal Disease (Giovanni A is an author of this paper, therefore, the peer review process was managed by alternative members of the Board and the submitting Editor was not involved in the decision-making process., (© The Author(s), 2022.)

Published
2022
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43. Correspondence on 'Characteristics associated with hospitalisation for COVID-19 in people with rheumatic disease: data from the COVID-19 Global Rheumatology Alliance physician-reported registry' by Gianfrancesco et al . Disease activity, rather than glucocorticoid therapy, may be associated with COVID-19 severity in patients with rheumatic musculoskeletal diseases.

Author

Giollo A, Bertoldo E, Adami G, Cybulski AJ, Fassio A, Orsolini G, Idolazzi L, Gatti D, Viapiana O, and Rossini M

Subjects
Glucocorticoids therapeutic use, Hospitalization, Humans, Registries, Antirheumatic Agents therapeutic use, COVID-19, Physicians, Rheumatic Diseases complications, Rheumatic Diseases drug therapy, Rheumatology
Abstract

Competing Interests: Competing interests: None declared.

Published
2022
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44. High plasma C5a and C5b-9 levels during quiescent phases are associated to severe antiphospholipid syndrome subsets.

Author

Ruffatti A, Tonello M, Calligaro A, Del Ross T, Favaro M, Zen M, Carletto A, Lotti V, Bertoldo E, Tedesco F, Hoxha A, and Biasi D

Subjects
Humans, Complement Membrane Attack Complex, Antibodies, Antiphospholipid, Anticoagulants therapeutic use, Antiphospholipid Syndrome complications, Antiphospholipid Syndrome diagnosis, Antiphospholipid Syndrome drug therapy, Thrombosis drug therapy, Thrombosis etiology
Abstract

Objectives: High plasma C5a and C5b-9 levels are considered a clear sign of complement activation. We aimed to evaluate the clinical significance of these two complement activation products during quiescent phases of thrombotic antiphospholipid syndrome (APS) by comparing their plasma levels in the different clinical subsets and relating them to the clinical characteristics and antiphospholipid antibody profile of the patients., Methods: The three patient subsets studied were: i) thrombotic patients responsive to anti-vitamin K therapy (TAPS); ii) patients with refractory to vitamin K antagonists recurrent thrombosis (RAPS); iii) patients diagnosed with catastrophic APS (CAPS). Plasma C5a and C5b-9 levels were assessed using commercial ELISA assays., Resulyts: Sixty-two quiescent APS patients were recruited: 40 were affected by TAPS, 13 by RAPS and 9 by CAPS. Data analysis showed that the TAPS patients had significantly lower levels of both complement activation products with respect to the RAPS and CAPS patients. In addition, C5a and/or C5b-9 significantly prevailed in the patients with small-vessel thrombosis, just as C5b-9 did in the triple antiphospholipid antibody positive patients. The ROC curve showed that the best cut-offs for C5a and C5b-9 levels had a higher sensitivity, specificity and likelihood ratio in the CAPS and RAPS groups than they did in the TAPS subset., Conclusions: These results suggest that the persistence of high plasma C5b-9 and C5a levels during quiescent phases identifies APS patients with more severe disease who may develop rethrombosis and benefit from complement inhibition treatment during an acute disease phase.

Published
2022
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46. Association between long-term exposure to air pollution and immune-mediated diseases: a population-based cohort study.

Author

Adami G, Pontalti M, Cattani G, Rossini M, Viapiana O, Orsolini G, Benini C, Bertoldo E, Fracassi E, Gatti D, and Fassio A

Subjects
Cohort Studies, Environmental Exposure adverse effects, Environmental Exposure analysis, Female, Humans, Male, Particulate Matter adverse effects, Particulate Matter analysis, Air Pollutants adverse effects, Air Pollutants analysis, Air Pollution adverse effects, Air Pollution analysis
Abstract

Objective: Environmental air pollution has been associated with disruption of the immune system at a molecular level. The primary aim of the present study was to describe the association between long-term exposure to air pollution and risk of developing immune-mediated conditions., Methods: We conducted a retrospective observational study on a nationwide dataset of women and men. Diagnoses of various immune-mediated diseases (IMIDs) were retrieved. Data on the monitoring of particulate matter (PM)10 and PM2.5 concentrations were retrieved from the Italian Institute of Environmental Protection and Research. Generalised linear models were employed to determine the relationship between autoimmune diseases prevalence and PM., Results: 81 363 subjects were included in the study. We found a positive association between PM10 and the risk of autoimmune diseases (ρ+0.007, p 0.014). Every 10 µg/m 3 increase in PM10 concentration was associated with an incremental 7% risk of having autoimmune disease. Exposure to PM10 above 30 µg/m3 and PM2.5 above 20 µg/m 3 was associated with a 12% and 13% higher risk of autoimmune disease, respectively (adjusted OR (aOR) 1.12, 95% CI 1.05 to 1.20, and aOR 1.13, 95% CI 1.06 to 1.20). Exposure to PM10 was associated with an increased risk of rheumatoid arthritis; exposure to PM2.5 was associated with an increased risk of rheumatoid arthritis, connective tissue diseases (CTDs) and inflammatory bowel diseases (IBD)., Conclusion: Long-term exposure to air pollution was associated with higher risk of developing autoimmune diseases, in particular rheumatoid arthritis, CTDs and IBD. Chronic exposure to levels above the threshold for human protection was associated with a 10% higher risk of developing IMIDs., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.)

Published
2022
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47. The clinical phenotype of systemic sclerosis patients with anti-PM/Scl antibodies: results from the EUSTAR cohort.

Author

Lazzaroni MG, Marasco E, Campochiaro C, DeVries-Bouwstra J, Gonzalez-Perez MI, Rojas-Serrano J, Hachulla E, Zanatta E, Barsotti S, Furini F, Triantafyllias K, Abignano G, Truchetet ME, De Luca G, De Langhe E, Hesselstrand R, Ingegnoli F, Bertoldo E, Smith V, Bellando-Randone S, Poormoghim H, Colombo E, Ceribelli A, Furloni A, Zingarelli S, Cavazzana I, Franceschini F, Del Galdo F, Denton CP, Cavagna L, Distler O, Allanore Y, and Airò P

Subjects
Adult, Autoantibodies, Europe epidemiology, Female, Humans, Male, Middle Aged, Phenotype, Retrospective Studies, Scleroderma, Systemic complications, Scleroderma, Systemic epidemiology, Exoribonucleases immunology, Exosome Multienzyme Ribonuclease Complex immunology, Registries, Scleroderma, Systemic immunology
Abstract

Objective: To evaluate clinical associations of anti-PM/Scl antibodies in patients with SSc in a multicentre international cohort, with particular focus on unresolved issues, including scleroderma renal crisis (RC), malignancies, and functional outcome of interstitial lung disease (ILD)., Methods: (1) Analysis of SSc patients from the EUSTAR database: 144 anti-PM/Scl+ without SSc-specific autoantibodies were compared with 7202 anti-PM/Scl-, and then to 155 anti-Pm/Scl+ with SSc-specific antibodies. (2) Case-control study: additional data were collected for 165 anti-PM/Scl+ SSc patients (85 from the EUSTAR registry) and compared with 257 anti-PM/Scl- SSc controls, matched for sex, cutaneous subset, disease duration and age at SSc onset., Results: Patients with isolated anti-PM/Scl+, as compared with anti-Pm/Scl-, had higher frequency of muscle involvement, ILD, calcinosis and cutaneous signs of DM, but similar frequency of SRC and malignancies (either synchronous with SSc onset or not). The presence of muscle involvement was associated with a more severe disease phenotype. Although very frequent, ILD had a better functional outcome in cases than in controls. In patients with both anti-PM/Scl and SSc-specific antibodies, a higher frequency of typical SSc features than in those with isolated anti-PM/Scl was observed., Conclusion: The analysis of the largest series of anti-PM/Scl+ SSc patients so far reported helps to delineate a specific clinical subset with muscle involvement, cutaneous DM, calcinosis and ILD characterized by a good functional outcome. SRC and malignancies do not seem to be part of this syndrome., (© The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)

Published
2021
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48. Association between environmental air pollution and rheumatoid arthritis flares.

Author

Adami G, Viapiana O, Rossini M, Orsolini G, Bertoldo E, Giollo A, Gatti D, and Fassio A

Subjects
Adult, Aged, Air Pollutants analysis, Air Pollution analysis, Arthritis, Rheumatoid blood, C-Reactive Protein analysis, Cross-Over Studies, Cross-Sectional Studies, Environmental Exposure analysis, Female, Humans, Italy, Longitudinal Studies, Male, Middle Aged, Registries, Air Pollutants adverse effects, Air Pollution adverse effects, Arthritis, Rheumatoid chemically induced, Environmental Exposure adverse effects, Symptom Flare Up
Abstract

Objectives: Environmental air pollution has been linked to the pathogenesis of RA. Nevertheless, evidence linking higher concentrations of air pollutants with the risk of RA reactivations is missing. The objective of the present study was to determine the association between RA flares and air pollution., Methods: We collected longitudinal data of patients affected by RA and of the daily concentration of air pollutants in the Verona area. We designed a case-crossover study. We compared the exposure to pollutants in the 30-day and 60-day periods preceding an arthritic flare referent to the 30-day and 60-day preceding a low-disease activity visit., Results: The study included 888 patients with RA with 3396 follow-up visits; 13 636 daily air pollution records were retrieved. We found an exposure-response relationship between the concentration of air pollutants and the risk of having abnormal CRP levels. Patients exposed to greater concentrations of air pollutants were at higher risk of having CRP levels ≥5 mg/l. Concentrations of CO, NO, NO2, NOx, PM10, PM2.5 and O3 were higher in the 60-day period preceding a flare., Conclusions: We found a striking association between air pollution and RA disease severity and reactivations in a cohort of patients followed over a 5-year period. The exposure to high levels of air pollutants was associated with increased CRP levels and a higher risk of experiencing a flare of arthritis. This excessive risk was evident at very low levels of exposure., (© The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)

Published
2021
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49. Pharmacodynamics of Oral Cholecalciferol in Healthy Individuals with Vitamin D Deficiency: A Randomized Open-Label Study.

Author

Fassio A, Gatti D, Rossini M, Benini C, Fracassi E, Bertoldo E, Viapiana O, Milleri S, Gatti M, and Adami G

Subjects
Adult, Biomarkers blood, Bone Remodeling drug effects, Calcium blood, Female, Fibroblast Growth Factor-23, Healthy Volunteers, Humans, Male, Middle Aged, Phosphates blood, Vitamin D Deficiency blood, Cholecalciferol administration & dosage, Vitamin D Deficiency drug therapy, Vitamins administration & dosage
Abstract

Comparative pharmacodynamic (PD) analyses on different dosing schedules for cholecalciferol supplementation are limited. This was an open-label, randomized, parallel-group study involving 75 healthy individuals deficient in vitamin D (baseline 25OHD < 20 ng/mL) receiving oral cholecalciferol with three different dosing regimens: Group A: 10,000 IU/day for 8 weeks followed by 1000 IU/day for 4 weeks; Group B: 50,000 IU/week for 12 weeks and Group C: 100,000 IU every other week for 12 weeks. Regulators of calcium and phosphate homeostasis, bone turnover markers and Wnt inhibitors were measured at baseline, Day 28, 53, 84, and 112. The 1,25OH2D increased at each time point. The increase was greater ( p < 0.05) for group A vs. B and C at Day 28, and vs. group B at Day 56. No significant difference among groups was observed for the other biomarkers. The 24,25OH2D remained stable over time. PTH decreased at Day 84 and FGF-23 increased at all time points. CTX-I and PINP increased slightly at Day 28. BALP decreased from Day 56 onward. Dkk-1 increased from Day 56 onward, while sclerostin did not show significant changes. In healthy individuals deficient in vitamin D, vitamin D supplementation exerted effects on multiple regulators of calcium, phosphate and bone metabolism, without marked differences using the three regimens.

Published
2021
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50. Association of anti-RNA polymerase III antibody with silicone breast implants rupture in a multicentre series of Italian patients with systemic sclerosis.

Author

Lazzaroni MG, Campochiaro C, Bertoldo E, De Luca G, Caimmi C, Tincani A, Franceschini F, and Airò P

Subjects
Autoantibodies, Female, Humans, Italy epidemiology, RNA Polymerase III, Retrospective Studies, Silicones, Breast Implants adverse effects, Scleroderma, Systemic diagnosis
Abstract

Objectives: Systemic sclerosis (SSc) is a heterogeneous systemic autoimmune disease with distinct subsets identified by specific autoantibodies. Some environmental agents might play a role in SSc pathogenesis, including silicone breast implants (SBI). This association has been controversial in previous literature and only few studies reported the auto-antibody status in these SSc women. The objective of this study was to evaluate the association of SBI with SSc in a large cohort of Italian patients, classified according to their SSc-related autoantibodies and to their history of breast cancer., Methods: Three Italian referral centres retrospectively collected clinical and laboratory data of consecutive SSc women, that were included when fulfilling the 2013 ACR/EULAR criteria and when SSc specific auto-antibodies status was available (anti-centromere (ACA), anti-Topoisomerase I (anti-Topo I) and anti-RNA Polymerase III antibodies (anti-RNAP3)). Data regarding history of SBI, SBI rupture and breast cancer were recorded., Results: Among 742 SSc women, a history of SBI was recorded in 12 patients (1.6%); in only 1 case the implantation occurred after SSc diagnosis. In SSc patients with anti- RNAP3+ a significantly higher frequency of SBI rupture and SBI rupture without breast cancer were observed, as compared to anti-RNAP3-negative patients. No association was noted for SBI without rupture., Conclusions: In this study we demonstrated a link between SBI rupture and induction of anti-RNAP3+ SSc; further studies are needed to better define the characteristics of this syndrome and the possible effects of SBI removal and immunosuppressive treatment.

Published
2021
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