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1. Postbariatric hypoglycemia: symptom patterns and associated risk factors in the Longitudinal Assessment of Bariatric Surgery study

Author

Berk, Paul D., Bessler, Marc, Daud, Amna, Lobdell, Harrison, IV, Mwelu, Jemela, Schrope, Beth, Ude, Akuezunkpa, Honohan, Jamie, Capasso, Michelle, Costa, Ricardo, Dakin, Greg, Ebel, Faith, Gagner, Michel, Hsieh, Jane, Pomp, Alfons, Strain, Gladys, Bowden, Rita, Chapman, William, Cundiff, Blair, Ball, Mallory, Cunningham, Emily, Dohm, Lynis, Pender, John, Pories, Walter, Barker, Jennifer, Howell, Michael, Garcia, Luis, Lancaster, Kathy, Lovaas, Erika, Mitchell, James E., Monson, Tim, Cassady, Chelsea, Coburn, Emily, Moher, Emily, Deveney, Clifford, Elder, Katherine, Greene, Stefanie, Purnell, Jonathan, O’Rourke, Robert, Sorenson, Chad, Wolfe, Bruce M., Patterson, Emma, Raum, William, VanDerWerff, Lisa, Kwiatkowski, Jason, Courcoulas, Anita P., Gourash, William, McCloskey, Carol A., Ramanathan, Ramesh, Kalarchian, Melissa, Marcus, Marsha, Shirley, Eleanor, Turo, Angela, Flum, David R., Dellinger, E. Patchen, Khandelwal, Saurabh, Stewart, Skye D., Cooley, Morgan M., Blissell, Rebecca, Miller, Megan J., Thirlby, Richard, Chang, Lily, Hunter, Jeffrey, Moonka, Ravi, Ng, Debbie, Belle, Steven H., King, Wendy C., Martin, Debbie, Mercurio, Rocco, Wahed, Abdus, Averbach, Frani, Horlick, Mary, Miles, Carolyn W., Staten, Myrlene A., Yanovski, Susan Z., Kleiner, David E., Fischer, Laura E., Fino, Nora, Elman, Miriam R., Pories, Walter J., Purnell, Jonathan Q., and Patti, Mary-Elizabeth

Published
2021
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8. Post-transcriptional activation of PPAR alpha by KLF6 in hepatic steatosis

Author

Bechmann, Lars P., Vetter, Diana, Ishida, Junichi, Hannivoort, Rebekka A., Lang, Ursula E., Kocabayoglu, Peri, Fiel, M. Isabel, Muñoz, Ursula, Patman, Gillian L., Ge, Fengxia, Yakar, Shoshana, Li, Xiaosong, Agius, Loranne, Lee, Young-Min, Zhang, Weijia, Hui, Kei Yiu, Televantou, Despina, Schwartz, Gary J., LeRoith, Derek, Berk, Paul D., Nagai, Ryozo, Suzuki, Toru, Reeves, Helen L., and Friedman, Scott L.

Published
2013
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15. Thirty-day Mortality After Bariatric Surgery: Independently Adjudicated Causes of Death in the Longitudinal Assessment of Bariatric Surgery

Author

Smith, Mark D., Patterson, Emma, Wahed, Abdus S., Belle, Steven H., Berk, Paul D., Courcoulas, Anita P., Dakin, Gregory F., Flum, David R., Machado, Laura, Mitchell, James E., Pender, John, Pomp, Alfons, Pories, Walter, Ramanathan, Ramesh, Schrope, Beth, Staten, Myrlene, Ude, Akuezunkpa, and Wolfe, Bruce M.

Published
2011
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17. Insulin- and leptin-regulated fatty acid uptake plays a key causal role in hepatic steatosis in mice with intact leptin signaling but not in ob/ob or db/db mice

Author

Ge, Fengxia, Zhou, Shengli, Hu, Chunguang, Lobdell, Harrison, IV., and Berk, Paul D.

Subjects
Insulin -- Physiological aspects, Gene expression -- Research, Fatty acids -- Synthesis, Fatty acids -- Physiological aspects, Biological sciences
Abstract

Hepatic steatosis results from several processes. To assess their relative roles, hepatocellular long-chain fatty acid (LCFA) uptake was assayed in hepatocytes from C57BL/6J control mice, mice with steatosis from a high-fat diet (HFD) or 10%, 14%, or 18% ethanol (EtOH) in drinking water [functioning leptin-signaling groups (FLSGs)], and ob/ob and db/db mice. [V.sub.max] for uptake was increased vs. controls (P < 0.001) and correlated significantly with liver weight and triglycerides (TGs) in all FLSG mice but was minimally or not increased in ob/ob and db/db mice, in which liver weights and TGs greatly exceeded projections from regressions in FLSG animals. Coefficients of determination ([R.sup.2]) for these FLSG regressions suggest that increased LCFA uptake accounts for ~80% of the increase in hepatic TGs within these groups, but increased lipogenic gene expression data suggest that enhanced LCFA synthesis is the major contributor in ob/ob and db/db. Got2, Cd36, Slc27a2, and Slc27a5 gene expression ratios were significantly upregulated in the EtOH groups, correlating with sterol regulatory element binding protein 1c (SREBP1c) and [V.sub.max], but only Cd36 expression was increased in HFD, ob/ob, and db/db mice. Comparison of [V.sub.max] with serum insulin and leptin suggests that both hormones contribute to upregulation of uptake in the FLSG animals. Thus, increased LCFA uptake, reflecting SREBPlc-mediated upregulation of four distinct transporters, is the dominant cause of steatosis in EtOH-fed mice. In ob/ob and db/db mice, increased LCFA synthesis appears more important. In FLSG animals, insulin upregulates hepatocellular LCFA uptake. Leptin appears to upregulate LCFA uptake or to be essential for full expression of upregulation by insulin. ethanol; fatty acid transport; fatty acid synthesis; gene expression; obesity doi: 10.1152/ajpgi.00434.2009.

Published
2010

22. Leptin and insulin modulate nutrient partitioning and weight loss in ob/ob mice through regulation of long-chain fatty acid uptake by adipocytes

Author

Fan, Xinqing, Bradbury, Michael W., and Berk, Paul D.

Subjects
Weight loss -- Physiological aspects, Obesity -- Health aspects, Leptin -- Health aspects, Food/cooking/nutrition
Abstract

Leptin treatment of ob/ob mice leads to weight loss appreciably greater than that in pair-fed mice. To test whether this 'extra' weight loss is mediated by leptin-induced alterations in nutrient partitioning, the effects in ob/ob mice of subcutaneous leptin infusion (500 ng/h for [less than or equal to] 21 d) on adipocyte fatty acid uptake and transporter gene expression were examined. Mice were initially hyperinsulinemic (5.25 [+ r or -] 1.57 nmol/L). Plasma insulin decreased by 55 [+ or -] 10% within 8 h of leptin infusion, declining progressively to normal by d 14. The [V.sub.max] for saturable adipocyte fatty acid uptake fell from 31.1 [+ or -] 5.6 to 25.2 [+ r or -] 4.0 pmol/(s * 50,000 cells) (P < 0.05) by 24 h, and to a normal rate (8.0 [+ or -] 0.8 pmol/(s * 50,000 cells) by d 21 (P > 0.5 vs. normal C57BL/6J controls). Adipocyte mRNA levels for plasma membrane fatty acid binding protein and fatty acid translocase, putative fatty acid transporters that are up-regulated three- to fourfold in adipocytes from ob/ob mice, had also normalized by d 21. The initial changes in [V.sub.max] preceded decreases in food intake and body weight by at least 24 h. In pair-fed mice, insulin levels, [V.sub.max] and body weight all declined more slowly than in leptin-treated mice, and all remained significantly elevated compared with normal values at d 21. The data suggest that insulin up-regulates and leptin down-regulates adipocyte fatty acid uptake, leading to alterations in fatty acid partitioning that affect adiposity. KEY WORDS: * obesity * nutrient partitioning * animal models * membrane transport

Published
2003

41. Facilitated Long Chain Fatty Acid Uptake by Adipocytes Remains Upregulated Relative to BMI for More Than a Year After Major Bariatric Surgical Weight Loss*

Author

Ge, Fengxia, Walewski, José L, Torghabeh, Mehyar Hefazi, Lobdell, Harrison, Hu, Chunguang, Zhou, Shengli, Dakin, Greg, Pomp, Alfons, Bessler, Marc, Schrope, Beth, Ude-Welcome, Aku, Inabnet, William B, Feng, Tianshu, Carras-Terzian, Elektra, Anglade, Dieunine, Ebel, Faith E., and Berk, Paul D.

Subjects
Adult, Male, obesity, bariatric surgery, adipocytes, Fatty Acids, Subcutaneous Fat, Middle Aged, Article, fatty acid uptake, Body Mass Index, Up-Regulation, spexin, Gastrectomy, Weight Loss, Humans, Female, Omentum, Follow-Up Studies
Abstract

This study examined whether changes in adipocyte long chain fatty acid (LCFA) uptake kinetics explain the weight regain increasingly observed following bariatric surgery.Three groups (10 patients each) were studied: patients without obesity (NO: BMI 24.2 ± 2.3 kg m(-2) ); patients with obesity (O: BMI 49.8 ± 11.9); and patients classified as super-obese (SO: BMI 62.6 ± 2.8). NO patients underwent omental and subcutaneous fat biopsies during clinically indicated abdominal surgeries; O were biopsied during bariatric surgery, and SO during both a sleeve gastrectomy and at another bariatric operation 16 ± 2 months later, after losing 113 ± 13 lbs. Adipocyte sizes and [(3) H]-LCFA uptake kinetics were determined in all biopsies.Vmax for facilitated LCFA uptake by omental adipocytes increased exponentially from 5.1 ± 0.95 to 21.3 ± 3.20 to 68.7 ± 9.45 pmol/sec/50,000 cells in NO, O, and SO patients, respectively, correlating with BMI (r = 0.99, P0.001). Subcutaneous results were virtually identical. By the second operation, the mean BMI (SO patients) fell significantly (P0.01) to 44.4 ± 2.4 kg m(-2) , similar to the O group. However, Vmax (40.6 ± 11.5) in this weight-reduced group remained ~2X that predicted from the BMI:Vmax regression among NO, O, and SO patients.Facilitated adipocyte LCFA uptake remains significantly upregulated ≥1 year after bariatric surgery, possibly contributing to weight regain.

Published
2015

44. Contributors

Author

Abrams, Charles S., Adler, Ronald S., Akin, Cem, Aksamit, Allen J., Jr., Al-Awqati, Qais, Allos, Ban Mishu, Anderson, Jeffrey L., Angus, Derek C., Appel, Gerald B., Appelbaum, Frederick R., Armitage, James O., Armstrong, Deborah K., Arnaout, M. Amin, Arnold, Robert M., Atkins, David, Atkinson, John P., Ayanian, John Z., Baddour, Larry M., Bagby, Grover C., Bain, Barbara J., Bajorin, Dean F., Baloh, Robert W., Bangham, Charles R.M., Barasch, Jonathan, Barbano, Richard L., Barrett, Bruce, Bartholomew, John R., Bartleson, J.D., Barton, Mary, Basner, Robert C., Bass, Anne R., Baum, Stephen G., Bauman, Julie E., Bausch, Daniel G., Bayer, Arnold S., Bazari, Hasan, Bazarian, Jeffrey J., Beigel, John H., Bel, Elisabeth H., Beller, George A., Berger, Joseph R., Berk, Paul D., Berliner, Nancy, Bernat, James L., Bierman, Philip J., Biesecker, Leslie G., Bishop, Michael R., Biundo, Joseph J., Blankson, Joel N., Blattner, William A., Bleck, Thomas P., Bloch, Karen C., Blom, Henk J., Bodamer, Olaf A., Boden, William E., Boivin, Guy, Bolognia, Jean, Bonnez, William, Bonomo, Robert A., Booth, Sarah L., Bosque, Patrick J., Breakwell, Lucy, Brenner, David J., Brochard, Laurent, Brook, Itzhak, Brunetti, Enrico, Bryant, Amy E., Buchner, David M., Buffet, Pierre A., Bushinsky, David A., Bykerk, Vivian P., Byrd, John C., Calabresi, Peter A., Calfee, David P., Camaschella, Clara, Camilleri, Michael, Cappellini, Maria Domenica, Carabello, Blase A., Carvalho, Edgar M., Catherino, William H., Cauley, Jane A., Chalasani, Naga P., Chambers, Henry F., Chang, Larry W., Chen, Lin H., Chen, Sharon C-A, Cheshire, William P., Jr., Chockalingam, Arun, Christiani, David C., Chu, Edward, Cieslak, Theodore J., Cioffi, George A., Clancy, Carolyn M., Clauss, Heather E., Clauw, Daniel J., Clemmons, David R., Cohen, David, Cohen, Jeffrey, Cohen, Myron S., Cohen, Steven P., Cohn, Steven L., Connors, Joseph M., Cook, Deborah J., Cooper, David S., Craft, Joseph, Crandall, Jill P., Croft, Simon L., Crow, Mary K., Crump, John A., Cudkowicz, Merit E., Cullen, Mark R., Cunningham-Rundles, Charlotte, Damon, Inger K., Daniels, Troy E., Dart, Richard, Davidson, Nancy E., DeAngelis, Lisa M., DeCamp, Malcolm M., Rio, Carlos Del, DeLuca, Gabriele C., Denning, David W., Deuster, Patricia A., Diasio, Robert B., Diemert, David J., Digre, Kathleen B., Doroshow, James. H., Douglas, John M., Jr., Drazen, Jeffrey M., Drekonja, Dimitri, Dreskin, Stephen C., Drew, W. Lawrence, Drusano, George L., DuBose, Thomas D., Jr., Dumler, J. Stephen, DuPont, Herbert L., Duvic, Madeleine, Edwards, Kathryn M., Edwards, N. Lawrence, Einhorn, Lawrence H., Eliopoulos, George M., Elliott, Perry M., Ellner, Jerrold J., Emanuel, Ezekiel J., Ernst, Joel D., Everson, Gregory T., Evoli, Amelia, Falagas, Matthew E., Falk, Gary W., Fang, James C., Feder, Gene, Feller-Kopman, David J., File, Thomas McDonald, Jr., Firestein, Gary S., Fishman, Glenn I., Fleisher, Lee A., Flint, Paul W., Fogel, Evan L., Forsmark, Chris E., Fournier, Pierre-Edouard, Fowler, Vance G., Jr., Franco, Manuel A., Freedman, David O., French, Martyn A., Freund, Karen M., Galgiani, John N., Gallagher, Patrick G., Ganz, Leonard, Garan, Hasan, Garcia-Tsao, Guadalupe, Geisler, William M., George, Tony P., Gepstein, Lior, Gerber, Susan I., Gerding, Dale N., Gertz, Morie A., Ghanem, Khalil G., Gill, Christopher J., Ginsberg, Jeffrey S., Ginsburg, Geoffrey S., Glesby, Marshall J., Gnann, John W., Jr., Golden, Matthew R., Goldman, David L., Goldman, Lee, Goldstein, Larry B., Gore, Richard M., Gotlib, Jason, Gotuzzo, Eduardo, Grammer, Leslie C., Grasemann, Hartmut, Grayson, M. Lindsay, Greenberg, Harry B., Greenberg, Steven A., Greer, David M., Griggs, Robert C., Grinberg, Lev M., Grossman, Daniel, Guay-Woodford, Lisa M., Gulick, Roy M., Gupta, Rajesh, Hadigan, Colleen, Hagman, Melissa M., Hagspiel, Klaus D., Handsfield, H. Hunter, Harris, Raymond C., Hayden, Frederick G., Hecht, Frederick M., Heimburger, Douglas C., Hensrud, Donald D., Hewlett, Erik L., Hift, Richard J., Hill, David R., Hill, Nicholas S., Hillyer, Christopher D., Hoit, Brian D., Holland, Steven M., Hollenberg, Steven M., Hook, Edward W., III, Howard, Jo, Hunter, David J., Hussain, Khalid, Iannuzzi, Michael C., Inman, Robert D., Inouye, Sharon K., Ison, Michael G., Jacobson, Karen R., Jaff, Michael R., Jen, Joanna C., Jensen, Dennis M., Jensen, Michael D., Jensen, Robert T., Joffe, Alain, Johnson, Stuart, Jones, Robin L., Jones, Sian, Jonklaas, Jacqueline, Jordan, Richard C., Kahi, Charles J., Kamya, Moses R., Kao, Louise W., Kaplan, Steven A., Kastner, Daniel L., Katzka, David A., Katzman, Debra K., Kauffman, Carol A., Kaushansky, Kenneth, Kaye, Keith S., Keating, Armand, Kelley, Robin K., Kern, Morton J., Keusch, Gerald T., Khuri, Fadlo R., Kirchhoff, Louis V., Kirtane, Ajay J., Klion, Amy D., Knopman, David S., Ko, Christine J., Kontoyiannis, Dimitrios P., Koppel, Barbara S., Korenblat, Kevin M., Korf, Bruce R., Kortepeter, Mark G., Kottilil, Shyamasundaran, Kovacs, Joseph A., Kovacs, Thomas O., Kowdley, Kris V., Kraft, Monica, Kramer, Christopher M., Krasnewich, Donna M., Kratz, Alexander, Kraus, Virginia Byers, Kraus, William E., Krause, Peter J., Kroshinsky, Daniela, Kuemmerle, John F., Kuipers, Ernst J., Laheru, Daniel, Landry, Donald W., Lang, Anthony E., Lange, Richard A., Lederle, Frank A., Lee, William M., Leggett, James E., Levine, Glenn N., Levine, Marc S., Levine, Stephanie M., Lichtenstein, Gary R., Liebmann, Jeffrey M., Lim, Henry W., Lima, Aldo A.M., Ling, Geoffrey S.F., Link, Mark S., Lloyd-Jones, Donald M., Lorber, Bennett, Louie, Arnold, Lucey, Daniel R., Lyness, Jeffrey M., MacKenzie, C. Ronald, MacMillan, Harriet L., Madoff, Robert D., Maldarelli, Frank, Malhotra, Atul, Manary, Mark J., Manu, Peter, Marcos, Luis A., Marelli, Ariane J., Mariette, Xavier, Marks, Andrew R., Marr, Kieren A., Marrie, Thomas J., Martin, Paul, Martinez, Fernando J., Mason, Joel B., Masur, Henry, Mathers, Amy J., Matteson, Eric L., Matthay, Michael A., Mayer, Emeran A., Mayer, Stephan A., McCool, F. Dennis, McInnes, Iain, McKenna, William J., McLaughlin, Vallerie, McMurray, John J.V., McQuaid, Kenneth R., Mead, Paul S., Means, Robert T., Jr., Meintjes, Graeme, Melton-Meaux, Genevieve B., Merrick, Samuel T., Michel, Marc, Mink, Jonathan W., Mitch, William E., Molitoris, Bruce A., Montoya, José G., Moy, Ernest, Mukherjee, Debabrata, Murr, Andrew H., Musher, Daniel M., Myerburg, Robert J., Nadeau, Kari C., Naides, Stanley J., Nash, Theodore E., Nath, Avindra, Neal-Perry, Genevieve, Neff, Anne T., Neilson, Eric G., Nelson, Christina A., Nelson, Lewis S., Nestler, Eric J., Newman, Anne B., Nicolle, Lindsay E., Nieman, Lynnette K., Nocturne, Gaetane, O’Connor, Christopher M., O’Connor, Francis G., O’Connor, Patrick G., O'Dell, James R., O'Donnell, Anne E., Oh, Jae K., Okhuysen, Pablo C., Okun, Michael S., Olgin, Jeffrey E., Olsen, Nancy J., Orenstein, Walter A., O'Shea, John J., Osmon, Douglas R., Otto, Catherine M., Ottolini, Martin G., Pappas, Peter G., Park, Ben Ho, Pasricha, Pankaj Jay, Patel, Manisha, Patel, Robin, Paterson, David L., Pawlotsky, Jean-Michel, Payne, Thomas H., Pearson, Richard D., Perl, Trish M., Pesce, Michael A., Petersen, Brett W., Petri, William A., Jr., Pfeffer, Marc A., Pisetsky, David S., Powell, Frank, Pyeritz, Reed E., Quinn, Thomas C., Racaniello, Vincent R., Radhakrishnan, Jai, Radich, Jerald, Rafailidis, Petros I., Raghu, Ganesh, Ragni, Margaret V., Raja, Srinivasa N., Rajkumar, S. Vincent, Ralston, James D., Ralston, Stuart H., Raoult, Didier, Ratner, Adam J., Reboli, Annette C., Reddy, K. Rajender, Redelmeier, Donald A., Reef, Susan E., Reilly, John, Reller, Megan E., Resnick, Neil M., Reuben, David B., Robinson, Jennifer G., Rogatsky, Inez, Rogers, Joseph G., Rolain, Jean-Marc, Rollins, Barrett J., Romero, José R., Rosene-Montella, Karen, Rosenthal, Philip J., Russell, James A., Rustgi, Anil K., Rusyniak, Daniel E., Sakoulas, George, Salata, Robert A., Salmon, Jane E., Salvana, Edsel Maurice T., Santoro, Nanette, Santos, Renato M., Santucci, Peter A., Savard, Patrice, Sawka, Michael N., Scanlon, Paul D., Schafer, Andrew I., Schaffner, William, Scheld, W. Michael, Schiff, Manuel, Schilsky, Michael L., Schooley, Robert T., Schriger, David L., Schuchter, Lynn M., Schulman, Sam, Schwartz, Lawrence B., Seas, Carlos, Seifert, Steven A., Seifter, Julian Lawrence, Selcen, Duygu, Semrad, Carol E., Shamoon, Harry, Shaw, Pamela J., Shaz, Beth H., Sheridan, Robert L., Sherman, Stuart, Shieh, Wun-Ju, Shy, Michael E., Sidransky, Ellen, Siegel, Richard M., Sifri, Costi D., Siliciano, Robert F., Simberkoff, Michael S., Simel, David L., Skorecki, Karl, Slutsky, Arthur S., Small, Eric J., Smetana, Gerald W., Smith, Gordon, Sobieszczyk, Magdalena E., Southwick, Frederick S., Spiegel, Allen M., Spiera, Robert, Spinola, Stanley M., Stabler, Sally P., Stanford, Stephanie M., Stark, Paul, Steensma, David P., Steiner, Theodore S., Stephens, David S., Stevens, David A., Stevens, Dennis L., Stoller, James K., Stone, John H., Stone, Richard M., Strikas, Raymond A., Su, Edwin P., Sutter, Roland W., Swerdloff, Ronald S., Swygard, Heidi, Sykes, Megan, Talbot, H. Keipp, Tanofsky-Kraff, Marian, Tarlo, Susan M., Teirstein, Paul S., Telford, Sam R., III, Thakker, Rajesh V., Therrien, Judith, Thompson, George R., III, Tosti, Antonella, Trehan, Indi, Turner, Ronald B., Valeri, Anthony Michael, Varga, John, Vaughn, Bradley V., Venook, Alan P., Verbalis, Joseph G., Victor, Ronald G., Vincent, Angela, Vincent, Tonia L., Wachter, Robert M., Wagner, Edward H., Walsh, Edward E., Walsh, Thomas J., Walston, Jeremy D., Walter, Roland B., Wang, Christina, Ware, Lorraine B., Warren, Cirle A., Watson, John T., Weber, Thomas J., Weinberg, Geoffrey A., Weinstein, David A., Weinstein, Robert S., Weiss, Roger D., Weiss, Roy E., Weitz, Jeffrey I., Wenzel, Richard P., Werth, Victoria P., West, Sterling G., White, A. Clinton, Jr., White, Christopher J., White, Julian, White, Perrin C., Whitley, Richard J., Whyte, Michael P., Wiebe, Samuel, Wiener-Kronish, Jeanine P., Wilber, David J., Winikoff, Beverly, Winter, Jane N., Wolin, Edward M., Wormser, Gary P., Young, Neal S., Young, Vincent B., Young, William F., Jr., Yu, Alan S.L., Zaidi, Anita K.M., Zaki, Sherif, Ziegler, Thomas R., and Zimetbaum, Peter

Published
2020
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47. Increased Hepatocellular Uptake of Long Chain Fatty Acids Occurs by Different Mechanisms in Fatty Livers Due to Obesity or Excess Ethanol Use, Contributing to Development of Steatohepatitis in Both Settings

Author

Berk, Paul D, Zhou, Shengli, and Bradbury, Michael W

Subjects
Male, Fatty Acids, Biological Transport, Active, Rats, Inbred Strains, In Vitro Techniques, Article, Rats, Mutant Strains, Rats, Fatty Liver, Mice, Hepatocytes, Animals, Humans, lipids (amino acids, peptides, and proteins), Obesity, Fatty Liver, Alcoholic
Abstract

Long chain fatty acids (LCFA) enter cells by both facilitated transport and diffusion, the former accounting foror = 90%. Facilitated LCFA transport is up-regulated in adipocytes from obese rats, mice, and humans. To clarify the role of hepatocellular LCFA uptake in hepatic steatosis (fatty liver), [3H]-oleic acid (OA) uptake was studied in hepatocytes isolated from Zucker fatty(Z) and control(C) and ethanol-fed(E) Wistar rats, and demonstrated both saturable and non-saturable components, each a function of the unbound OA concentration ([OAu]). The uptake Vmax was identical in C and Z animals, but was increased 2.4-fold in E animals (p0.01). The non-saturable uptake rate constant did not differ between groups. Plasma LCFAs averaged 600 microM in C and E and 1,200 microM in Z animals. Total LCFA uptake averaged 1.35, 2.78 and 3.54 pmol/sec/50,000 cells in C, Z, and E animals, respectively. A 2-fold uptake increase in Z animals, in which Vmax was unaltered, entirely reflected the increased plasma LCFA concentration, whereas the 2.6-fold increase in E animals, in which plasma LCFA were not increased, resulted from up-regulation of facilitated transport. Thus, while increased hepatic LCFA uptake contributes to pathogenesis of hepatic steatosis in both obesity and excessive ethanol consumption, the mechanisms differ.

Published
2005

48. Contributors

Author

Abrams, Charles S., Accurso, Frank J., Adler, Ronald S., Akin, Cem, Aksamit, Allen J., Jr., Al-Awqati, Qais, Allos, Ban Mishu, Altshuler, David, Aminoff, Michael, Anderson, Jeffrey L., Anderson, Larry J., Antony, Aśok C., Appel, Gerald B., Appelbaum, Frederick R., Apte, Suneel S., Armitage, James O., Arnaout, M. Amin, Arnold, Robert M., Atkins, David, Atkinson, John P., Bacon, Bruce R., Baddour, Larry M., Bagby, Grover C., Bain, Barbara J., Bajorin, Dean F., Baloh, Robert W., Barasch, Jonathan, Barbano, Richard L., Barrett-Connor, Elizabeth, Bartholomew, John R., Barton, Mary, Basner, Robert C., Baum, Stephen G., Bausch, Daniel G., Bayer, Arnold S., Bazari, Hasan, Beigel, John H., Beller, George A., Bennett, Robert M., Berger, Joseph R., Berk, Paul D., Berliner, Nancy, Bernat, James L., Bierman, Philip J., Bishop, Michael R., Bistrian, Bruce R., Biundo, Joseph J., Black, Adrian R., Blanke, Charles D., Blankson, Joel N., Blaser, Martin J., Blattner, William A., Bleck, Thomas P., Block, Joel A., Blom, Henk, Bodamer, Olaf A., Boden, William E., Bolognia, Jean, Bonomo, Robert A., Borish, Larry, Bosque, Patrick J., Brenner, David J., Brook, Itzhak, Brunetti, Enrico, Buchner, David M., Buffet, Pierre A., Bunn, H. Franklin, Bushinsky, David A., Bykerk, Vivian P., Calabresi, Peter A., Calfee, David P., Cameron, Douglas, Camilleri, Michael, Cannon, Grant W., Cappellini, Maria Domenica, Carabello, Blase A., Carvalho, Edgar M., Catherino, William H., Cauley, Jane A., Chalasani, Naga P., Chambers, Henry F., Cheshire, William P., Jr., Cho, Ilseung, Chockalingam, Arun, Christiani, David C., Chu, David H., Cieslak, Theodore J., Clancy, Carolyn, Clemmons, David R., Cohen, David, Cohen, Jeffrey, Cohen, Myron S., Cohen, Steven P., Cohn, Steven L., Colebunders, Robert, Connors, Joseph M., Cook, Deborah J., Cowan, Kenneth H., Craft, Joseph, Crandall, Jill Patricia, Croft, Simon L., Crothers, Kristina, Crow, Mary K., Crump, John A., Cullen, Mark R., Cunningham-Rundles, Charlotte, Damon, Inger K., Daniels, Troy E., Davidson, Nancy E., DeAngelis, Lisa M., DeCamp, Malcolm M., del Rio, Carlos, Deuster, Patricia A., Diasio, Robert B., Diemert, David J., Digre, Kathleen B., Doroshow, James H., Douglas, John M., Jr., Drazen, Jeffrey M., Dreskin, Stephen C., Drew, W. Lawrence, Drusano, George L., DuBose, Thomas D., Jr., Duffy, F. Daniel, DuPont, Herbert L., Duvic, Madeleine, Edwards, Kathryn M., Edwards, N. Lawrence, Einhorn, Lawrence H., Elin, Ronald J., Eliopoulos, George M., Elliott, Perry, Ellner, Jerrold J., Elston, Dirk M., Emanuel, Ezekiel J., Ernst, Joel D., Everson, Gregory T., Evoli, Amelia, Faigel, Douglas O., Falagas, Matthew E., Falk, Gary W., Feder, Gene, Feller-Kopman, David J., Firestein, Gary S., Fishman, Glenn I., Fleisher, Lee A., Flint, Paul W., Fogel, Evan L., Ford, Marsha D., Forsmark, Chris E., Fowler, Vance G., Jr., Franco, Manuel A., Freedman, David O., French, Martyn A., Freund, Karen, Gabay, Cem, Gage, Kenneth L., Galgiani, John N., Gallagher, Patrick G., Ganz, Leonard, Garan, Hasan, Garcia-Tsao, Guadalupe, Geisler, William M., George, Tony P., Gepstein, Lior, Gerber, Susan I., Gerding, Dale N., Gertz, Morie A., Ginder, Gordon D., Ginsberg, Jeffrey S., Ginsburg, Geoffrey S., Glogauer, Michael, Gnann, John W., Jr., Golden, Matthew R., Goldman, Lee, Goldstein, Larry B., Goodnough, Lawrence T., Gotuzzo, Eduardo H., Grady, Deborah, Grammer, Leslie C., Greco, F. Anthony, Greenberg, Harry B., Greenberg, Steven A., Griggs, Robert C., Grinberg, Lev M., Grossman, Daniel, Guay-Woodford, Lisa M., Guerrant, Richard L., Gulick, Roy M., Hagspiel, Klaus D., Hainsworth, John D., Hamsten, Anders, Hande, Kenneth R., Handsfield, H. Hunter, Hansson, Göran K., Harris, Raymond C., Hauser, Stephen Crane, Hayden, Frederick G., Healey, Letha M., Heimburger, Douglas C., Hewlett, Erik L., Hift, Richard J., Hill, David R., Hill, Nicholas S., Hillis, L. 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Published
2016
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49. Facilitated long chain fatty acid uptake by adipocytes remains upregulated relative to BMI for more than a year after major bariatric surgical weight loss.

Author

Ge, Fengxia, Walewski, José L., Torghabeh, Mehyar Hefazi, Lobdell, Harrison, Hu, Chunguang, Zhou, Shengli, Dakin, Gregory, Pomp, Alfons, Bessler, Marc, Schrope, Beth, Ude‐Welcome, Aku, Inabnet, William B., Feng, Tianshu, Carras‐Terzian, Elektra, Anglade, Dieunine, Ebel, Faith E., and Berk, Paul D.

Subjects
FATTY acids, FAT cells, BARIATRIC surgery, BODY mass index, GASTRECTOMY, BIOPSY, STATISTICAL correlation, ADIPOSE tissue surgery, ADIPOSE tissues, BIOCHEMISTRY, LONGITUDINAL method, PHENOMENOLOGY, OBESITY, OMENTUM, RESEARCH funding, WEIGHT loss
Abstract

Objective: This study examined whether changes in adipocyte long chain fatty acid (LCFA) uptake kinetics explain the weight regain increasingly observed following bariatric surgery.Methods: Three groups (10 patients each) were studied: patients without obesity (NO: BMI 24.2 ± 2.3 kg m(-2) ); patients with obesity (O: BMI 49.8 ± 11.9); and patients classified as super-obese (SO: BMI 62.6 ± 2.8). NO patients underwent omental and subcutaneous fat biopsies during clinically indicated abdominal surgeries; O were biopsied during bariatric surgery, and SO during both a sleeve gastrectomy and at another bariatric operation 16 ± 2 months later, after losing 113 ± 13 lbs. Adipocyte sizes and [(3) H]-LCFA uptake kinetics were determined in all biopsies.Results: Vmax for facilitated LCFA uptake by omental adipocytes increased exponentially from 5.1 ± 0.95 to 21.3 ± 3.20 to 68.7 ± 9.45 pmol/sec/50,000 cells in NO, O, and SO patients, respectively, correlating with BMI (r = 0.99, P < 0.001). Subcutaneous results were virtually identical. By the second operation, the mean BMI (SO patients) fell significantly (P < 0.01) to 44.4 ± 2.4 kg m(-2) , similar to the O group. However, Vmax (40.6 ± 11.5) in this weight-reduced group remained ~2X that predicted from the BMI:Vmax regression among NO, O, and SO patients.Conclusions: Facilitated adipocyte LCFA uptake remains significantly upregulated ≥1 year after bariatric surgery, possibly contributing to weight regain. [ABSTRACT FROM AUTHOR]

Published
2016
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