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245 results on '"Bergamini, Ettore"'

9. Effect of aging and anti-aging caloric restriction on the endocrine regulation of rat liver autophagy

Author

Donati, Alessio, Recchia, Gianluca, Cavallini, Gabriella, and Bergamini, Ettore

Subjects
Aging -- Health aspects, Aging -- Physiological aspects, Liver -- Properties, Insulin -- Properties, Insulin -- Control, Metabolism -- Research, Glucagon -- Properties, Glucagon -- Influence, Health, Seniors
Abstract

Autophagy is a process that sequesters and degrades altered organelles and macromolecular cytoplasmic constituents for cellular restructuring and repair, and as a source of nutrients for metabolic use in early starvation it may be involved in anti-aging mechanisms of caloric restriction. The effects of 40% daily dietary restriction (DR) and intermittent feeding (EOD) on the age-related changes in the endocrine regulation of autophagic proteolysis were studied by monitoring the rate of valine release from isolated rat liver cells. Results show that in ad libitumfed rats sensitivity of autophagy to glucagon and insulin declines by one order of magnitude in older rats. Both DR and EOD maintain the sensitivity to glucagon at juvenile levels, whereas only EOD can fully maintain response to insulin. It is concluded that changes in the sensitivity to glucagon may have a role in the aging process. Key Words: Autophagy--Caloric restriction--Aging--Insulin--Glucagon.

Published
2008

13. Accumulation of dolichol in older tissues satisfies the proposed criteria to be qualified a biomarker of aging

Author

Parentini, Ilaria, Cavallini, Gabriella, Donati, Alessio, Gori, Zina, and Bergamini, Ettore

Subjects
Tissues, Biological markers, Aging, Health, Seniors
Abstract

Criteria for defining biomarkers have been suggested. Accumulation of dolichol in tissues of older animals meets the following criteria: (a) levels of dolichol exhibit a quantitative correlation with age in all tissues and are not altered by several age-dependent diseases in the same direction as that of aging; (b) accumulation is not secondary to metabolic changes of aging and is altered appropriately by factors that modulate the aging rate like caloric restriction and physical exercise; (c) biomarker is applicable to different tissues across mammalian species, including humans, and to trisomy 21 and its hypothalamic digoxin-mediated model. Reliable changes in tissue dolichol levels are seen in relatively short intervals of time compared to over a life span, and levels can be tested on a small amount of tissue without causing death of the animal. In this article, we show applications to the study of host-graft interaction and detection of gender-related differences in biological age, and we discuss mechanism(s) of accumulation.

Published
2005

34. Prolonged Exposure to Free Fatty Acids Has Cytostatic and Pro-Apoptotic Effects on Human Pancreatic Islets: Evidence that β-Cell Death Is Caspase Mediated, Partially Dependent on Ceramide Pathway, and Bcl-2 Regulated

Author

Lupi, Roberto, Dotta, Francesco, Marselli, Lorella, Del Guerra, Silvia, Masini, Matilde, Santangelo, Carmela, Patané, Giovanni, Boggi, Ugo, Piro, Salvatore, Anello, Marcello, Bergamini, Ettore, Mosca, Franco, Di Mario, Umberto, Del Prato, Stefano, and Marchetti, Piero

Published
2002

36. Insulin secretory function is impaired in isolated human islets carrying the [Gly.sup.972] → Arg IRS-1 polymorphism. (Brief Genetics Report)

Author

Marchetti, Piero, Lupi, Roberto, Federici, Massimo, Marselli, Lorella, Masini, Matilde, Boggi, Ugo, Del Guerra, Silvia, Patane, Giovanni, Piro, Salvatore, Anello, Marcello, Bergamini, Ettore, Purrello, Francesco, Lauro, Renato, Mosca, Franco, Sesti, Giorgio, and Del Prato, Stefano

Subjects
Islands of Langerhans -- Physiological aspects -- Genetic aspects, Genetic polymorphisms -- Physiological aspects -- Genetic aspects, Type 2 diabetes -- Genetic aspects, Health, Physiological aspects, Genetic aspects
Abstract

Type 2 (non-insulin-dependent) diabetes results from decreased insulin action in peripheral target tissues (insulin resistance) and impaired pancreatic β-cell function. These defects reflect both genetic components and environmental risk factors. [...]

Published
2002

38. Primary Prevention of Alzheimer’s Disease (AD)

Author

Bergamini, Ettore and Cavallini, Gabriella

Subjects
Medical
Abstract

Alzheimer dementia (AD) is a complex, aging-associated disease whose effects on the brain (an organ made up by nonreplaceable cells) are devastating. Disease is not curable, but progress in pathobiology shows that intervention on aging can make primary prevention of AD feasible. According to the amyloid-cascade hypothesis, mechanisms of AD include: an age-related alteration of free radical metabolism in membranes, leading to a higher yield in the toxic Aβ1-42 peptide and an overwhelming impact on the weaker repair mechanisms of the aging cells. The proposed intervention on aging with anti-AD effects includes a daily assumption of antioxidants (red wine polyphenols enriched with resveratrol), a reinforcement of membrane antioxidant defenses by the assumption of polyunsaturated fatty acids at the first meal after fasting, and an enhancement of cell repair function (at the proteasome and autophagy level by an intermittent feeding regimen and physical exercise plus the assumption of antilipolytic agents during time of fasting). The beneficial effects of diet and physical activity on the endogenous production of protective nerve growth factors are magnified by an enriched environment. Treatment has already been started on healthy individuals at a higher risk of AD in the city of Volterra.

Published
2018

48. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

Author

Klionsky, Daniel J., Abeliovich, Hagai, Agostinis, Patrizia, Agrawal, Devendra K., Aliev, Giumrakch, Askew, David S., Baba, Misuzu, Baehrecke, Eric H., Bahr, Ben A., Ballabio, Andrea, Bamber, Bruce A., Bassham, Diane C., Bergamini, Ettore, Bi, Xiaoning, Biard-Piechaczyk, Martine, Blum, Janice S., Breclesen, Dale E., Brodsky, Jeffrey, Brumell, John H., Brunk, Ulf T., Bursch, Wilfried, Camougrand, Nadine, Cebollero, Eduardo, Cecconi, Francesco, Chen, Yingyu, Chin, Lih-Shen, Choi, Augustine, Chu, Charleen T., Chung, Jongkyeong, Clarke, Peter G. H., Clark, Robert S. B., Clarke, Steven G., Clavé, Corinne, Cleveland, John L., Codogno, Patrice, Colombo, Maria I., Coto-Montes, Ana, Cregg, James M., Cuervo, Ana Maria, Debnath, Jayanta, Demarchi, Francesca, Dennis, Patrick B., Dennis, Phillip A., Deretic, Vojo, Devenish, Rodney J., Di Sano, Federica, Dice, J. Fred, Difiglia, Marian, Dinesh-Kumar, Savithramma, Distelhorst, Clark W., Djavaheri-Mergny, Mojgan, Dorsey, Frank C., Dröge, Wulf, Dron, Michel, Dunn Jr., William A., Duszenko, Michael, Eissa, N. Tony, Elazar, Zvulun, Esclatine, Audrey, Eskelinen, Eeva-Liisa, Fesus, Laszlo, Finley, Kim D., Fuentes, José M., Fueyo, Juan, Fujisaki, Kozo, Galliot, Brigitte, Gao, Fen-Biao, Gewirtz, David A., Gibson, Spencer B., Gohla, Antje, Goldberg, Alfred L., Gonzalez, Ramon, González-Estévez, Cristina, Gorski, Sharon, Gottlieb, Roberta A., Häussinger, Dieter, He, You-Wen, Heidenreich, Kim, Hill, Joseph A., Hoyer-Hansen, Maria, Hu, Xun, Huang, Wei-Pang, Iwasaki, Akiko, Jäättelä, Marja, Jackson, William T., Jiang, Xuejun, Jin, Shengkan, Johansen, Terje, Jung, Jae U., Kadowaki, Motoni, Kang, Chanhee, Kelekar, Ameeta, Kessel, David H., Kiel, Jan A.K.W., Kim, Hong Pyo, Kimchi, Adi, Kinsella, Timothy J., Kiselyov, Kirill, Kitamoto, Katsuhiko, Knecht, Erwin, Komatsu, Masaaki, Kominami, Eiki, Konclo, Seiji, University of Michigan [Ann Arbor], University of Michigan System, Hebrew University of Jerusalem, Université Catholique de Louvain = Catholic University of Louvain (UCL), Creighton University, The University of Texas Health Science Center at Houston (UTHealth), University of Cincinnati (UC), Department of Chemical and Biological Sciences, University of Huddersfield, University of Massachusetts Medical School [Worcester] (UMASS), University of Massachusetts System (UMASS), University of Connecticut (UCONN), Telethon Institute of Genetics and Medicine, University of Toledo, Department of Genetics, Development, and Cell Biology, Iowa State University (ISU), Universita degli studi di Pisa, Basic Medical Sciences, Western University of Health Sciences, Centre National de la Recherche Scientifique (CNRS), Indiana University, Indiana University System, Buck Institute for Research on Aging, Department of Biological Sciences, University of Pittsburgh (PITT), Pennsylvania Commonwealth System of Higher Education (PCSHE)-Pennsylvania Commonwealth System of Higher Education (PCSHE), Massachusetts General Hospital [Boston], Cell Biology Program, Utrecht University [Utrecht], Linköping University (LIU), Medizinische Universität Wien = Medical University of Vienna, Institut de biochimie et génétique cellulaires (IBGC), Université Bordeaux Segalen - Bordeaux 2-Centre National de la Recherche Scientifique (CNRS), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Università degli Studi di Roma Tor Vergata [Roma], Peking University, School of Medicine / Department of Pharmacology, University of California, Harvard University [Cambridge], Pennsylvania Commonwealth System of Higher Education (PCSHE), Korea Advanced Institute of Science and Technology (KAIST), Université de Lausanne (UNIL), Department of Chemistry and Biochemistry, University of California [Los Angeles] (UCLA), University of California-University of California, Molecular Biology Institute, Université de Bordeaux Ségalen [Bordeaux 2], Scripps Research Institute, Université Paris-Sud - Paris 11 (UP11), Signalisation et physiopathologie des cellules épithéliales, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de Oviedo [Oviedo], Keck Graduate Institute [Claremont, Californie] (KGI), Albert Einstein College of Medicine [New York], University of California [San Francisco] (UCSF), Consorzio Interuniversitario, National Cancer Institute, The University of New Mexico [Albuquerque], Monash University, Dipartimento Biol, University of Naples Federico II, Tufts University, Dept Neurol, Syngenta, Yale University, Partenaires INRAE, Case Western Reserve University [Cleveland], University Hospitals of Cleveland, Immunotec Research Ltd., Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892)), Institut National de la Recherche Agronomique (INRA), University of Florida [Gainesville] (UF), Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen, Baylor College of Medicine (BCM), Department of Biological Chemistry, Weizmann Institute of Science [Rehovot, Israël], University of Helsinki, University of Debrecen, Hungarian Academy of Sciences (MTA), Salk Institute for Biological Studies, Plant Molecular and Cellular Biology Laboratory, Universidad de Extremadura (UEX), University of Texas, Kagoshima University, Department of Zoology and Animal Biology, University of Geneva [Switzerland], Virginia Commonwealth University (VCU), University of Manitoba, University of Manitoba [Winnipeg], Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf], Department of Cell Biology, Charles University [Prague] (CU), University of Nottingham, UK (UON), British Columbia Cancer Agency, San Diego State University (SDSU), Duke University [Durham], University of Colorado [Boulder], University of Texas Southwestern Medical Center, Danish Cancer Society, Zhejiang University, National Taiwan Normal University (NTNU), Yale University [New Haven], Medical College of Wisconsin, Memorial Sloan Kettering Cancer Center, The University of Texas M.D. Anderson Cancer Center [Houston], University of Medecine and Dentistry of New Jersey, and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], phagophore, stress, [SDV]Life Sciences [q-bio], autophagosome, autolysosome
Abstract

La liste complète des auteurs est disponible sur la notice WOS : http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=INRA&SrcApp=INRA&DestLinkType=FullRecord&DestApp=WOS&KeyUT=ISI:000253008800003; International audience

Published
2008

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