15 results on '"Bellaaj H"'
Search Results
2. Patterns of gastrointestinal hemorrhage in hemophilia: PO-WE-010
- Author
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AJMI, N., KASSAR, O., MEDHAFFAR, M., KAMMOUN, R., BELLAAJ, H., KAMMOUN, L., HDIJI, S., and ELLOUMI, M.
- Published
- 2012
3. Interest of Thin Skin Flaps in the Treatment of Postburn Cervical Contractures: About Five Cases.
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Ghorbel, I., Bouaziz, F., Bellaaj, H., Moaalla, S., and Ennouri, Kh.
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THERAPEUTICS ,SURGICAL flaps ,SKIN ,PLASTIC surgery ,YOUNG adults - Abstract
Objectives. The use of thin skin flaps in the reconstruction of postburn cervical contractures associated with functional impacts. Material and Methods. We conducted a descriptive observational study on about five patients who had reconstruction of postburn cervical contractures using various thin skin flaps in a plastic surgery department. The follow-up period was ranged from 12 to 18 months. We determined the characteristics of the retraction according to the Vandenbussche classification, the indications of the flaps, and the functional and aesthetic results. Results. Most of our patients were young adults presenting segmental retraction of the neck associated with moderate functional impact. The occipito-cervico-dorsal flap was used in three cases. The occipito-cervico-shoulder flap was used in two cases. The aesthetic and functional results were satisfactory for all patients, but a "neck-collar" aspect of the cervical-chin angle was noticed. Conclusion. Postburn cervical contractures remain frequent. Their reconstruction is a difficult process as it is ideally done with a skin similar to the original one. The use of thin skin flaps seems to be an excellent option. [ABSTRACT FROM AUTHOR]
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- 2019
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4. GAUCHER'S DISEASE TYPE 1, ABOUT AN UNICENTRIC STUDY OF 4 PATIENTS OF LATE ONSET
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Mseddi, S., Kallel, F., Ben Rhouma, F., Jedidi, I., Ben Amar, Martine, Bellaaj, H., Mdhaffar, M., Ajmi, N., Kassar, O., Kallel, C., Boudawara, T., Beyrouti, I., Elloumi, M., Pasteur Tunis, Institut, Laboratory of Hematology, Hopital Habib Bourguiba - Habib Bourguiba Hospital [Sfax], Unité de recherche en Technologies de l'Information et de la Communication (UTIC), and Ecole Supérieure des Sciences et Techniques [Tunis] (ESSTT)
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[SDV] Life Sciences [q-bio] ,[SDV]Life Sciences [q-bio] ,health services administration ,education ,population characteristics ,health care economics and organizations ,geographic locations - Abstract
15th Annual Meeting of the European-Hematology-Association, Barcelona, SPAIN, jun-13, 2010; International audience; no abstract
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- 2010
5. Acute myeloid leukemia after one month of azathioprine therapy in a Crohn's disease patient.
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Kallel L, Naijaa N, Fekih M, Frikha I, Boubaker J, Bellaaj H, Romdhane NB, and Filali A
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- 2010
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6. Clinical utility and prognostic value of galactomannan in neutropenic patients with invasive aspergillosis
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Hadrich, I., Makni, F., Cheikhrouhou, F., Neji, S., Amouri, I., Sellami, H., Trabelsi, H., Bellaaj, H., Elloumi, M., and Ayadi, A.
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GALACTOMANNANS , *NEUTROPENIA , *ASPERGILLOSIS , *ETIOLOGY of diseases , *CAUSES of death , *HEALTH outcome assessment , *PROGNOSIS , *PATIENTS - Abstract
Abstract: Invasive aspergillosis (IA) is a major cause of morbidity and mortality in profoundly neutropenic patients. Delayed diagnosis and therapy may lead to poor outcomes. Aims: The objective of this study was to assess the performance characteristics of the galactomannan (GM) assay in serum and bronchoalveolar lavage specimens for the diagnosis of IA in neutropenic patients with hematological malignancies. We also evaluated the prognostic outcome. Patients and methods: A total of 1198 serum samples and 42 BAL from 235 neutropenic patients were tested with a GM elisa platelia test. We used Cox modeling of time to 6- and 12-week mortality for GM level at the time of diagnosis (GM0) and GM decay in the week following diagnosis in proven and probable IA patients with more than two GM values. Results: There were three proven, 55 probable, and four possible cases of IA. The sensitivity and specificity of the GM test were 96.8% and 82.4% respectively. In BAL samples, sensitivity was 86% and the specificity 93%. BAL GM was more sensitive than microscopy (22.2%) and BAL culture (38.9%). Among patients with proven/probable IA, serum and BAL GM were in agreement for 92.8% of paired samples. The hazard ratio (HR) of GM0 and 1-week GM decay per unit increase in Aspergillus enzyme immunoassay (EIA) was 1.044 (95% CI, 0.738 to 1.476) and 0.709 (95% CI, 0.236 to 2.130) respectively. Conclusion: We found good correlation between the GM0 and GM decay combination and outcome of IA patients. The GM is a useful tool for diagnosis and monitoring of IA. [Copyright &y& Elsevier]
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- 2012
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7. UIdataGB: Multi-Class ultrasound images dataset for gallbladder disease detection.
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Turki A, Obaid AM, Bellaaj H, Ksantini M, and AlTaee A
- Abstract
Artificial Intelligence (AI) allows computers to self-develop decision-making algorithms through huge data analysis. In medical investigations, using computers to automatically diagnose diseases is a promising area of research that could change healthcare strategies worldwide. However, it can be challenging to reproduce or/and compare various approaches due to the often-limited datasets comprising medical images. Since there is no open access dataset for the Gallbladder (GB) organ, we introduce, in this study, a large dataset that includes 10,692 GB Ultrasound Images (UI) acquired at high resolution from 1,782 individuals. These UI include many disease types related to the GB, and they are organized around nine important anatomical landmarks. The data in this collection can be used to train machine learning (ML) and deep learning (DL) models for computer-aided detection of GB diseases. It can also help academics conduct comparative studies and test out novel techniques for analyzing UI to explore the medical domain of GB diseases. The objective is then to help move medical imaging forward so that patients get better treatment., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors.)
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- 2024
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8. Detection of Gallbladder Disease Types Using Deep Learning: An Informative Medical Method.
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Obaid AM, Turki A, Bellaaj H, Ksantini M, AlTaee A, and Alaerjan A
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Nowadays, despite all the conducted research and the provided efforts in advancing the healthcare sector, there is a strong need to rapidly and efficiently diagnose various diseases. The complexity of some disease mechanisms on one side and the dramatic life-saving potential on the other side raise big challenges for the development of tools for the early detection and diagnosis of diseases. Deep learning (DL), an area of artificial intelligence (AI), can be an informative medical tomography method that can aid in the early diagnosis of gallbladder (GB) disease based on ultrasound images (UI). Many researchers considered the classification of only one disease of the GB. In this work, we successfully managed to apply a deep neural network (DNN)-based classification model to a rich built database in order to detect nine diseases at once and to determine the type of disease using UI. In the first step, we built a balanced database composed of 10,692 UI of the GB organ from 1782 patients. These images were carefully collected from three hospitals over roughly three years and then classified by professionals. In the second step, we preprocessed and enhanced the dataset images in order to achieve the segmentation step. Finally, we applied and then compared four DNN models to analyze and classify these images in order to detect nine GB disease types. All the models produced good results in detecting GB diseases; the best was the MobileNet model, with an accuracy of 98.35%.
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- 2023
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9. Chronic myeloid leukemia patients in Tunisia: epidemiology and outcome in the imatinib era (a multicentric experience).
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Ben Lakhal R, Ghedira H, Bellaaj H, Ben Youssef Y, Menif S, Manai Z, Bedoui M, Lakhal A, M'Sadek F, Elloumi M, Khélif A, Ben Romdhane N, Laatiri MA, Ben Othmen T, and Meddeb B
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- Adolescent, Adult, Aged, Aged, 80 and over, Antineoplastic Agents adverse effects, Child, Child, Preschool, Female, Follow-Up Studies, Humans, Imatinib Mesylate adverse effects, Leukemia, Myeloid, Accelerated Phase diagnosis, Leukemia, Myeloid, Accelerated Phase epidemiology, Leukemia, Myeloid, Accelerated Phase pathology, Leukemia, Myeloid, Chronic-Phase diagnosis, Leukemia, Myeloid, Chronic-Phase epidemiology, Leukemia, Myeloid, Chronic-Phase pathology, Male, Middle Aged, Practice Patterns, Physicians', Prognosis, Protein Kinase Inhibitors adverse effects, Retrospective Studies, Splenomegaly etiology, Splenomegaly pathology, Splenomegaly prevention & control, Survival Analysis, Tumor Burden drug effects, Tunisia epidemiology, Young Adult, Antineoplastic Agents therapeutic use, Imatinib Mesylate therapeutic use, Leukemia, Myeloid, Accelerated Phase drug therapy, Leukemia, Myeloid, Chronic-Phase drug therapy, Protein Kinase Inhibitors therapeutic use
- Abstract
Data are limited in developing countries regarding the clinicopathologic features and response to therapy of chronic myeloid leukemia (CML) in the era of imatinib (IM). The objective of this study is to report on the clinicoepidemiologic features of CML in Tunisia, to evaluate the long-term outcome of patients in chronic (CP) or accelerated phase (AP) treated with IM 400 mg daily as frontline therapy, and to determine imatinib's efficacy and safety. From October 2002 to December 2014, 410 CML patients were treated with IM in six Tunisian departments of hematology. Response (hematologic, cytogenetic, and molecular responses) and outcome-overall survival (OS), event-free survival (EFS), and progression-free survival (PFS)-were evaluated. The following prognostic factors were analyzed for their impact on the European leukemia net (ELN) response, OS, EFS, and PFS at 5 years: age, sex, leukocyte count, Sokal score, European Treatment and Outcome Study (EUTOS) score, CML phase, time to starting IM, and impact of adverse events. The median age was 45 years (3-85 years). Two hundred ten (51.2%) patients were male. Splenomegaly was present in 322 of the 410 (79%). Additional cytogenetic abnormalities were encountered in 25 (6.3%) patients. At diagnosis, 379 (92.4%) patients were in CP, 31 (7.6%) were in AP. The Sokal risk was low in 87 (22.5%), intermediate in 138 (35.7%), and high in 164 patients (41.9%). The EUTOS risk was low in 217 (74%), and high in 77 (26%) patients. The rates of cumulative complete cytogenetic response (CCyR), major molecular response (MMR), and molecular response 4/5 log (MR4.5) in CP/AP-CML patients were 72, 68.4, and 46.4%, respectively. The median time to reach CCyR, MMR, and MR4.5 was 6 months (3-51), 18 months (3-72), and 24 months (3-100), respectively. According to the ELN criteria, optimal, suboptimal response, and failure were noted in 206 (51.8%), 61 (15.3%), and 125 (31.4%) patients, respectively. Five-year event-free survival (EFS), progression-free survival (PFS), and overall survival (OS) were 81, 90, and 90%, respectively. By multivariate analysis, AP, high EUTOS risk, and baseline WBC ≥ 150G/l remained independent predictive factors of non-optimal response to IM. The adverse events (AE) of IM were moderate and tolerable. With the caveats that the monitoring of the disease was not optimal, response rates were similar to those reported in previous studies. It is clear to us that improvements should be made in treatment of AP-CML and high Sokal risk group of CP-CML. The frontline use of second-generation tyrosine kinase inhibitor (TKI) is expected to improve the results of the first-line treatment of these high-risk Tunisian patients, but cost and accessibility of this therapy remain the problems in developing countries.
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- 2018
- Full Text
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10. Molecular monitoring of Tunisian patients with chronic myeloid leukemia.
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Menif S, Ben Youssef Y, Bellaaj H, Ben Lakhal R, and Laatiri A
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- Adolescent, Adult, Aged, Biomarkers, Pharmacological analysis, Biomarkers, Tumor genetics, Drug Monitoring methods, Female, Humans, Leukemia, Myelogenous, Chronic, BCR-ABL Positive genetics, Leukemia, Myelogenous, Chronic, BCR-ABL Positive pathology, Male, Middle Aged, Neoplasm, Residual, Retrospective Studies, Treatment Outcome, Tunisia, Young Adult, Leukemia, Myelogenous, Chronic, BCR-ABL Positive diagnosis, Leukemia, Myelogenous, Chronic, BCR-ABL Positive drug therapy, Molecular Diagnostic Techniques methods, Monitoring, Physiologic methods, Protein Kinase Inhibitors therapeutic use, Real-Time Polymerase Chain Reaction
- Abstract
Background: bcr-abl fusion gene is the hallmark of chronic myeloid leukemia (CML). RQ-PCR provides an accurate measure of the total leukemia cell mass and the degree to which bcr-abl transcripts are reduced by therapy correlates with progression free survival., Aim: We report molecular assessment of residual disease in CML Tunisian patients., Methods: Between June 2003 and December 2014 we measured bcr-abl mRNA levels in peripheral blood from all Tunisian patients by quantitative real time polymerase chain reaction (RQ-PCR)., Results: A total of 708 patients with a mean age of 42 years were included in this study. Based on European Leukemia Net 2013, 80% of the patients achieved an optimal response 20% were in treatment failure. 38% of the patients achieved RM4 which corresponds to a bcr-abl/abl ratio <0.01%, 13% of the patients achieved RM4.5corresponding to bcr-abl/abl ratio of 0.0032%., Conclusion: CML patients had a good response to tyrosine kinase inhibitors treatment. RQ-PCR is helpful in detecting any residual disease and determining the depth of the treatment response.
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- 2017
11. hOCT1 gene expression predict for optimal response to Imatinib in Tunisian patients with chronic myeloid leukemia.
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Ben Hassine I, Gharbi H, Soltani I, Teber M, Farrah A, Ben Hadj Othman H, Amouri H, Bellaaj H, Lakhal RB, Romdhane NB, Abbes S, and Menif S
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- Adolescent, Adult, Aged, Alleles, Biomarkers, Tumor blood, Down-Regulation drug effects, Exons genetics, Female, Genotype, Humans, Male, Middle Aged, Octamer Transcription Factor-1 genetics, Polymorphism, Genetic genetics, Polymorphism, Single Nucleotide genetics, RNA, Messenger biosynthesis, RNA, Messenger genetics, Tunisia, Young Adult, Antineoplastic Agents therapeutic use, Imatinib Mesylate therapeutic use, Leukemia, Myelogenous, Chronic, BCR-ABL Positive drug therapy, Leukemia, Myelogenous, Chronic, BCR-ABL Positive genetics, Octamer Transcription Factor-1 biosynthesis, Protein Kinase Inhibitors therapeutic use
- Abstract
Purpose: Imatinib mesylate (IM) is considered as a highly effective therapy for chronic myeloid leukemia (CML) patients. However, a minority of patients fail to achieve optimal response due to impaired bioavailability of IM. The human organic cation transporter 1 (OCT1; SLC22A1) has been reported to be the main influx transporter involved in IM uptake into CML cells. Genetic variants and/or hOCT1 expression changes may influence IM response. In this study, we aimed to investigate the impact of both hOCT1 polymorphisms located in exon 7 and hOCT1 mRNA levels on the clinical outcome in CML patients., Methods: hOCT1 expression profile was determined using the quantitative real-time polymerase chain reaction in 69 CML patients treated with IM (35 responders to IM patients and 34 IM-resistant patients), while genotyping of 69 cases and 51 controls for hOCT1 polymorphisms was performed by direct sequencing after amplification of exon7., Results: Our results showed that the hOCT1 gene was significantly downregulated in the samples of the IM-resistant group when compared with the IM-responder group (p = 0.0211). Moreover, sequencing data show an association in all cases between the SNP 408V>M (g.1222G>A) and an intronic 8 bp (base pairs) insertion of GTAAGTTG (rs36056065) at the 3' end of exon 7. The genotype and allele distribution of the different SNPs did not differ significantly between the two groups of patients., Conclusions: hOCT1 mRNA expression may serve as a clinical biomarker of response to imatinib and could be useful to predict IM therapy outcome of CML patients.
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- 2017
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12. Chronic myeloid leukemia following the treatment of nasopharyngeal carcinoma.
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Kassar O, Mseddi S, Mdhaffer M, Bellaaj H, Mnif S, Ghorbel M, Sennena H, and Elloumi M
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- Adult, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Cisplatin administration & dosage, Cisplatin adverse effects, Combined Modality Therapy, Female, Fluorouracil administration & dosage, Fluorouracil adverse effects, Humans, Radiotherapy, Adjuvant, Leukemia, Myelogenous, Chronic, BCR-ABL Positive diagnosis, Nasopharyngeal Carcinoma therapy, Nasopharyngeal Neoplasms therapy, Neoplasms, Second Primary diagnosis
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- 2017
13. Acute acalculous cholecystitis complicating chemotherapy for acute myeloblastic leukemia.
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Kassar O, Kallel F, Ghorbel M, Bellaaj H, Mnif Z, and Elloumi M
- Abstract
Acute acalculous cholecystitis is a rare complication in the treatment of acute myeloblastic leukemia. Diagnosis of acute acalculous cholecystitis remains difficult during neutropenic period. We present two acute myeloblastic leukemia patients that developed acute acalculous cholecystitis during chemotherapy-induced neutropenia. They suffered from fever, vomiting and acute pain in the epigastrium. Ultrasound demonstrated an acalculous gallbladder. Surgical management was required in one patient and conservative treatment was attempted in the other patient. None treatment measures were effective and two patients died. Acute acalculous cholecystitis is a serious complication in neutropenic patients. Earlier diagnosis could have expedited the management of these patients.
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- 2015
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14. [Primary manifestation of small Lymphocytic Lymphoma in the Prostate: A case report].
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Kassar O, Gouiaa N, Mdhaffar M, Bellaaj H, Mseddi S, Boudawara T, Mhiri N, and Elloumi M
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- Aged, 80 and over, Antineoplastic Agents, Alkylating therapeutic use, Chlorambucil therapeutic use, Humans, Leukemia, Lymphocytic, Chronic, B-Cell drug therapy, Leukemia, Lymphocytic, Chronic, B-Cell pathology, Male, Prostatic Neoplasms drug therapy, Prostatic Neoplasms pathology, Leukemia, Lymphocytic, Chronic, B-Cell diagnosis, Prostatic Neoplasms diagnosis, Urinary Retention etiology
- Abstract
We report a case of Lymphocytic Lymphoma presenting with primary manifestation in the prostate. A 82 year-old man presented to emergency department with acute urinary retention. Digital rectal examination revealed a voluminous and firm prostate. Histology confirmed involvement of the prostate by small B Lymphocytic Lymphoma. The patient was treated with chlorambucil. Lymphocytic infiltration of prostate is a rare manifestation. However this may also be the first sign of an undiagnosed lymphoma. This observation shows that the prostatic lymphoma must be considered among the causes of low urinary retention.
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- 2015
15. Amphotericin B in vitro resistance is associated with fatal Aspergillus flavus infection.
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Hadrich I, Makni F, Neji S, Cheikhrouhou F, Bellaaj H, Elloumi M, Ayadi A, and Ranque S
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- Adolescent, Adult, Amphotericin B therapeutic use, Antifungal Agents therapeutic use, Aspergillus flavus isolation & purification, Cohort Studies, Female, Hematologic Neoplasms complications, Humans, Invasive Pulmonary Aspergillosis drug therapy, Male, Microbial Sensitivity Tests, Middle Aged, Survival Analysis, Treatment Outcome, Young Adult, Amphotericin B pharmacology, Antifungal Agents pharmacology, Aspergillus flavus drug effects, Drug Resistance, Fungal, Invasive Pulmonary Aspergillosis microbiology, Invasive Pulmonary Aspergillosis mortality
- Abstract
Whether in vitro antifungal susceptibility findings correlate with the outcome of patients with invasive aspergillosis (IA) remains debated. This study aimed to test whether IA patients' outcomes were associated with in vitro susceptibility results. To do so, we determined the in vitro susceptibility to amphotericin B (AMB) of 37 Aspergillus flavus isolates from 14 patients with haematological malignancies diagnosed with proven or probable IA, of which 13 were treated with AMB deoxycholate. Minimal inhibitory concentrations (MICs) were determined by Etest with the isolates classified as in vitro sensitive (AMB-S) or resistant (AMB-R) if their MICs were < 2 or ≥ 2 mg/l, respectively. The association of the patients' death with primary disease, administered antifungal treatment, and infection with AMB-R A. flavus was tested using generalized estimating equations logistic regression. We assessed AMB-R in 31/37 (84%) isolates. In the patients treated with AMB, the survival rate was 2/3 (67%) and 2/9 (22%) for those infected with AMB-S or AMB-R A. flavus, respectively. Both infection with AMB-R A. flavus (P = 0.014) strain and acute myelocytic leukaemia as the underlying primary disease (P = 0.036) were independent predictors of death. Our findings indicate that in vitro resistance predicts a poor outcome in patients with A. flavus invasive disease treated with AMB. Recent advances in non-culture-based microbiological methods should not discourage efforts to obtain in vitro antifungal susceptibility results, which are critical for the choice of antifungal therapy in patients with IA.
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- 2012
- Full Text
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