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WOS:000329790100028 PubMed: 25536747 Aim: To evaluate the role of 99m-technetium methylene diphosphonate (Tc-99m MDP) bone scintigraphy on the detection of joint damage in asymptomatic alpine ski racers. Materials and methods: This study included 20 male asymptomatic alpine ski racers (age range: 18-21 years). None of the skiers had a history of ski crashes. Bone scan findings of the racers were examined with Tc-99m MDP bone scintigraphy during the active racing season and the inactive training season. Planar anterior and posterior images of hip, knee, and ankle joints were obtained 4 h after intravenous injection of 20 mCi Tc-99m MDP. All images were interpreted visually by 2 experienced nuclear medicine physicians. Free regions of interest were drawn on hip, knee, and ankle joints, as well as background regions. Joint-to-background ratios were calculated for each joint, and the uptake ratios of both right and left joints during active ski season were compared to those during the inactive training period. Results: Uptake ratios of the right and left hip, knee, and ankle joints were significantly higher during the active racing period than those calculated during the inactive period (P < 0.005). Conclusion: Bone scintigraphy may have an important role in detecting joint injuries of hip, knee, and ankle joints in asymptomatic alpine ski racers and can be used successfully when MRI is unavailable.

Objective: Melatonin is a powerful endogenous antioxidant and it may play a role in preventionof radiation-induced damage. The aim of this study was to investigate the effect ofmelatonin on bone mineral density in rats receiving radiation.Materials and Methods: Sprague Dawley rats were divided into four groups. Group 1(control group) received neither melatonin nor radiation (control group). Group 2 (Melgroup) was administered intraperitoneal injections of 5mg/kg melatonin daily for ten days.Group 3 (RT group) and Group 4 were exposed to total cranium radiation of 5 Gy in a singledose by using a cobalt-60 teletherapy unit. In addition to irradiation, group 4 (RT + Melgroup) was administered 5mg/kg of melatonin intraperitoneally. At the end of the 10th day,the rats' cranium and vertebrae bone mineral densities (BMDs) were measured.Results: When cranial BMDs were evaluated, statistically more significant BMD increaseswere seen in the Mel group and the RT + Mel groups than in the control group. No significantdifference was seen in the Mel group versus the RT + Mel group; however, there wasa significant difference between RT and RT + Mel groups. When vertebral BMDs wereevaluated, the only significant difference was found between the control and Mel groups.Conclusion: We think that melatonin is a radioprotective agent. However, we would liketo emphasize that further studies are needed before clinical trials with melatonin are initiated.

The present study gives a detailed report of a patient with atypical Cogan's syndrome with uveitis and sensorineural hearing loss. Cogan's syndrome is characterized by nonsyphilitic interstitial keratitis and audiovestibular dysfunction. This syndrome can be divided into two groups, typical and atypical, based on the presence of interstitial keratitis. It may sometimes be associated with systemic vasculitis. Fluoro-D-glucose-positron emission tomography/computed tomography (FDG-PET/CT) scanning was used to investigate the presence of vasculitis. With FDG-PET/CT scanning, there is no pathological involvement in the walls of the arteries; thus the patient is protected from aggressive and long term immunosuppressive treatment's side effects. Hence, we can conclude that FDG-PET/CT may play an important role in excluding the presence of vasculitis.Çalışmamızda sensorinöral işitme kaybı ve üveiti olan atipik Cogan sendromlu bir hastayı detaylı bir şekilde ele aldık. Cogan sendromu nonsifilitik interstisyel keratit ve odiovestibuler disfonksiyon ile karakterize bir hastalıktır. Interstisyel keratitin varlığına göre Cogan sendromu tipik ve atipik olmak üzere iki gruba ayrılabilir. Bu sendroma bazen sistemik vaskülit eşlik edebilir. Fluoro-D-glucose-positron emission tomografi/bilgisayarlı tomografi (FDG-PET/BT) taraması sistemik vaskülit varlığının araştırılması amacı ile kullanılabilir. Bu amaçla hastaya yapılan FDG-PET/BT taraması ile arter duvarlarında patolojik bulgu saptanmadı. Böylece hasta uzun süreli ve agresif immünsüpresif tedavinin yan etkilerinden korunmuş oldu. Vaskülit varlığını dışlamada FDG-PET/BT taramasının önemli bir yeri olduğunu söyleyebiliriz.

We report a case of a patient with hepatocellular carcinoma (HCC) who presented with back pain related to bone metastasis. HCC metastasizes by hematogenous and lymphatic routes commonly to the lungs, regional lymph nodes, kidney, bone marrow and adrenals. In this extremely rare case, the patient had no known liver disease, but presented with liver lesions and multiple bone lesions involving vertebrae, ribs, pelvic bones and left femur with associated expansile soft-tissue components. These bone lesions were first detected from a positron emission tomography scan. Pathological examination of biopsy material taken from the left eighth rib confirmed metastatic HCC. In conclusion, if a patient has expansile osteolytic bone lesions, bone metastasis from HCC should be included in the differential diagnosis.

OP-048 Percutaneous coronary intervention (PCI) does not often have optimal results despite restoration of coronary blood flow at myocardial recovery because of impaired microvascular perfusion. Previous studies have focused on the starting time and dosage of tirofiban. This study aimed to