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696 results on '"Bartz-Schmidt, Karl-Ulrich"'

7. LASER FLARE PHOTOMETRY IN PRIMARY RHEGMATOGENOUS RETINAL DETACHMENT: An Evaluation of 2,487 Cases

Author

Gietzelt, Caroline, Hoerster, Robert, Schiller, Petra, Hermann, Saskia, Kraus, Daria, Holz, Frank G., Guthoff, Rainer, Agostini, Hansjürgen, Spitzer, Martin S., Wiedemann, Peter, Lommatzsch, Albrecht, Boden, Karl T., Bartz-Schmidt, Ulrich, Bemme, Sebastian, Tamm, Svenja, Maier, Mathias, Roider, Johann, Kirchhof, Bernd, Fauser, Sascha, Schaub, Friederike, Altay, Lebriz, Bartz-Schmidt, Karl Ulrich, Callizo, Josep, Dahlke, Claudia, Dimopoulos, Spyridon, Eberwein, Philipp, Ehlken, Christoph, Enders, Philip, Feltgen, Nicolas, Gamulescu, Andreea, Gelisken, Faik, Gutfleisch, Matthias, Haus, Arno, Helbig, Horst, Hermann, Manuel, Januschowski, Kai, Jochmann, Claudia, Kaya, Sema, Kirchhof, Bernd, Krohne, Tim, Lagrèze, Wolf, Lange, Clemens, Lohmann, Chris, Lommatzsch, Albrecht, Macek, Marc Andrej, Maier, Mathias, Märker, David, Mayer, Christian, Meier, Petra, Menzel-Severing, Johannes, Molnar, Fanni, Müther, Philipp, Prahs, Philipp, Purtskhvanidze, Konstantine, Rehak, Matus, Rickmann, Annekatrin, Schick, Tina, Schmitz-Valckenberg, Steffen, Schultheiß, Maximilian, Schweig, Alexandra, Skevas, Christos, Stahl, Andreas, Szurman, Peter, Unterlauft, Jan Darius, Wakili, Philip, and Wozar, Fabian

Published
2024
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10. Intravitreal 5-Fluorouracil and Heparin to Prevent Proliferative Vitreoretinopathy: Results from a Randomized Clinical Trial

Author

Pfeiffer, Andrea, Willms, Sandra, Binder, Susanne, Le Mer, Yannik, Stützer, Hartmut, Lemmen, Klaus-Dieter, Heimke-Brinck, Ralph, Borst, Tobias, Bartz-Schmidt, Karl Ulrich, Callizo, Josep, Dahlke, Claudia, Eberwein, Philipp, Ehlken, Christoph, Feltgen, Nicolas, Gamulescu, Andreea, Gelisken, Faik, Gutfleisch, Matthias, Haus, Arno, Helbig, Horst, Hermann, Manuel, Januschowski, Kai, Jochmann, Claudia, Krohne, Tim, Lagrèze, Wolf, Lange, Clemens, Lohmann, Chris, Macek, Marc Andrej, Märker, David, Mayer, Christian, Meier, Petra, Müther, Philipp, Prahs, Philipp, Purtskhvanidze, Konstantine, Rehak, Matus, Schaub, Friederike, Schick, Tina, Schmitz-Valckenberg, Steffen, Schultheiß, Maximilian, Skevas, Christos, Stahl, Andreas, Szurman, Peter, Unterlauft, Jan Darius, Hellmich, Martin, Kuhr, Katrin, Schiller, Petra, Hoerster, Robert, Kraus, Daria, Holz, Frank G., Guthoff, Rainer, Agostini, Hansjürgen, Spitzer, Martin S., Wiedemann, Peter, Lommatzsch, Albrecht, Boden, Karl T., Dimopoulos, Spyridon, Bemme, Sebastian, Tamm, Svenja, Maier, Mathias, Roider, Johann, Enders, Philip, Altay, Lebriz, Fauser, Sascha, and Kirchhof, Bernd

Published
2022
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14. Analysis of retinal detachment resulted from post-operative endophthalmitis treated with 23G pars Plana Vitrectomy

Author

Zheng Ying, Casagrande Maria, Dimopoulos Spyridon, Bartz-Schmidt Karl-Ulrich, Spitzer Matin Stephan, and Skevas Christos

Subjects
Endophthalmitis, Retinal detachment, Pars Plana vitrectomy, 23 gauge, Ophthalmology, RE1-994
Abstract

Abstract Background To evaluate the rate, risk factors, functional outcome and prognosis in eyes with retinal detachment after post-operative endophthalmitis treated with 23G Pars Plana Vitrectomy. Methods Electronic patient files from 2009 until 2018 were screened for the presence of an endophthalmitis. Included were 116 eyes of 116 patients. This population was evaluated for the rate of retinal detachment after 23G Pars Plana Vitrectomy for endophthalmitis following cataract surgery or intravitreal injection. The main outcome measures were retinal detachment and visual acuity. Results The reasons for endophthalmitis were previous cataract surgery in 78 patients and following intravitreal injection in 38 patients. The first clinical evidence of endophthalmitis was present in median 5 days after the triggering intervention. Twenty-five eyes (21.55%) developed a retinal detachment an average of 25 days after endophthalmitis. RD is significantly associated with preoperative visual acuity (p = 0.001). Conclusions We emphasize the prognostic role of preoperative visual acuity in RD development of the endophthalmitis treated with 23G Pars Plana Vitrectomy.

Published
2021
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27. Incidence of central retinal artery occlusion peaks in winter season.

Author

Gassel, Caroline J., Andris, Wolfgang, Poli, Sven, Bartz-Schmidt, Karl Ulrich, Dimopoulos, Spyridon, and Wenzel, Daniel A.

Subjects
RETINAL artery, RETINAL artery occlusion, SEASONAL variations of diseases, AIR pollutants, ATMOSPHERIC temperature, SPRING, WINTER
Abstract

Introduction: Stroke incidence exhibits seasonal trends, with the highest occurrences observed during winter. This study investigates the incidence of central retinal artery occlusion (CRAO), a stroke equivalent of the retina, and explores its monthly and seasonal variations, as well as potential associations with weather and ambient air pollutants. Methods: A retrospective search of medical records spanning 15 years (January 2008-December 2022) was conducted at the University Eye Hospital Tübingen, Germany, focusing on diagnosed cases of CRAO. Incidences were evaluated on amonthly and seasonal basis (winter, spring, summer, fall). Weather data (temperature, precipitation, atmospheric pressure) and concentrations of ambient air pollutants [fine particulate matter (PM2.5), coarse particulate matter (PM10), nitrogen dioxide (NO2), and ozone (O3)], were analyzed for a potential association with CRAO incidence. Results: Out of 432 patients diagnosed with CRAO between 2008 and 2022, significantly varying incidences were observed monthly (p = 0.025) and seasonally (p = 0.008). The highest rates were recorded in February and winter, with the lowest rates in June and summer. Concentrations of NO2, PM2.5 and lower ambient air temperature (average, minimum, maximum) showed significant correlations with CRAO incidence. Discussion: This comprehensive 15-year analysis reveals a pronounced winter peak in CRAO incidence, with the lowest occurrences in summer. Potential associations between CRAO incidence and ambient air pollutants and temperature underscore the importance of considering seasonal trends and call for further investigations to elucidate contributing factors, potentially leading to targeted preventive strategies and public health interventions. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Pupillotonia after endolaser retinopexy during vitrectomy for retinal detachment: a prospective cohort study comparing circumferential and focal retinopexy.

Author

Skevas, Christos, Thiwa, David, Bartz-Schmidt, Karl-Ulrich, Katz, Toam, Spitzer, Martin, and Dimopoulos, Spyridon

Abstract

Purpose To determine differences in postoperative pupil diameter in eyes that undergo pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD) with endolaser retinopexy (ELR), comparing 360° vs focal ELR. Methods Patients with uncomplicated RRD who underwent PPV were prospectively analysed regarding the postoperative pupil diameter difference (PDD) between the affected eye and the partner eye. Group 1 underwent 360° ELR and group 2 received focal ELR. Postoperative vision and complications, including redetachment rate, macular oedema and epiretinal membrane formation, were also compared. Results A total of 72 patients, 42 in group 1 and 30 in group 2, were analysed. PDD, as observed at 6 weeks, was significantly greater than the preoperative values in both groups 1 and 2. It increased by a mean of 1±1.11 mm in group 1 and by 0.5±0.78 in group 2. This initial increase in PDD receded over time, but remained statistically significant in both groups, even at 6 months. The top 20% of patients with the largest PDD change comprised 13 out of 15 eyes from group 1, which was a statistically significant overrepresentation (p=0.0435). Conclusions Moderate pupillotonia was induced post-ELR in vitrectomy and correlated to the extent of ELR. The pupillotonia effect of ELR was significantly less marked in pseudophakic eyes. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Subretinal Visual Implant Alpha IMS – Clinical trial interim report

Author

Stingl, Katarina, Bartz-Schmidt, Karl Ulrich, Besch, Dorothea, Chee, Caroline K., Cottriall, Charles L., Gekeler, Florian, Groppe, Markus, Jackson, Timothy L., MacLaren, Robert E., Koitschev, Assen, Kusnyerik, Akos, Neffendorf, James, Nemeth, Janos, Naeem, Mohamed Adheem Naser, Peters, Tobias, Ramsden, James D., Sachs, Helmut, Simpson, Andrew, Singh, Mandeep S., Wilhelm, Barbara, Wong, David, and Zrenner, Eberhart

Published
2015
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38. A Case Study from the Past: "The RGC-5 vs. the 661W Cell Line: Similarities, Differences and Contradictions—Are They Really the Same?".

Author

Hurst, José, Attrodt, Gesine, Bartz-Schmidt, Karl-Ulrich, Mau-Holzmann, Ulrike Angelika, Spitzer, Martin Stephan, and Schnichels, Sven

Subjects
RETINAL ganglion cells, RETINAL degeneration, TUBULINS
Abstract

In the pursuit of identifying the underlying pathways of ocular diseases, the use of cell lines such as (retinal ganglion cell-5) RGC-5 and 661W became a valuable tool, including pathologies like retinal degeneration and glaucoma. In 2001, the establishment of the RGC-5 cell line marked a significant breakthrough in glaucoma research. Over time, however, concerns arose about the true nature of RGC-5 cells, with conflicting findings in the literature regarding their identity as retinal ganglion cells or photoreceptor-like cells. This study aimed to address the controversy surrounding the RGC-5 cell line's origin and properties by comparing it with the 661W cell line, a known cone photoreceptor model. Both cell lines were differentiated according to two prior published redifferentiation protocols under the same conditions using 500 nM of trichostatin A (TSA) and investigated for their morphological and neuronal marker properties. The results demonstrated that both cell lines are murine, and they exhibited distinct morphological and neuronal marker properties. Notably, the RGC-5 cells showed higher expression of the neuronal marker β-III tubulin and increased Thy-1-mRNA compared with the 661W cells, providing evidence of their different properties. The findings emphasize the importance of verifying the authenticity of cell lines used in ocular research and highlight the risks of contamination and altered cell properties. [ABSTRACT FROM AUTHOR]

Published
2023
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39. Development of retinal atrophy after subretinal gene therapy with voretigene neparvovec.

Author

Reichel, Felix Friedrich, Seitz, Immanuel, Wozar, Fabian, Dimopoulos, Spyridon, Jung, Ronja, Kempf, Melanie, Kohl, Susanne, Kortüm, Friederike Charlotte, Ott, Saskia, Pohl, Lisa, Stingl, Krunoslav, Bartz-Schmidt, Karl Ulrich, Stingl, Katarina, and Fischer, M. Dominik

Abstract

Background/aims Voretigene neparvovec (VN) is the first and only subretinal gene therapy approved by the Food and Drug Administration and European Medicines Agency. Real-world application has started in 2018 in patients with vision impairment due to biallelic retinal pigment epithelium (RPE) 65 mutation-associated inherited retinal degenerations. Herein, we evaluated the development of retinal atrophy within in a single-centre patient cohort treated with VN. Methods 13 eyes of eight patients treated with VN were retrospectively analysed for areas of retinal atrophy over a period of 6-24 months following surgery. Ultrawide field images were used to measure the area of atrophy. Fundus autofluorescence imaging is presented as an instrument for early detection of signs of retinal atrophy in these patients. Results Atrophic changes beyond the retinotomy site were observed in all eyes. Areas of atrophy developed within the area of detachment (bleb) in all eight patients and outside the bleb in three patients. Changes in autofluorescence preceded the development of retinal atrophy and were already evident 2weeks after surgery in the majority of patients. The areas of atrophy increase with time and progression continued over year 1. Functional outcomes remained stable (VA, FST, visual field). Conclusion Subretinal injection of VN can lead to RPE atrophy with consequent photoreceptor loss in and outside of the bleb area. Fundus autofluorescence is an important tool to monitor atrophic changes in patients after gene therapy. Interestingly, while areas of atrophy also included central areas, the functional benefits of the treatment did not appear to be affected and remained stable. [ABSTRACT FROM AUTHOR]

Published
2023
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44. Two Methods for the Isolation and Cultivation of Porcine Primary Corneal Cells.

Author

Netto, Alice Rocha Teixeira, Hrusa, Marc Dieter, Bartz-Schmidt, Karl-Ulrich, Schnichels, Sven, and Hurst, José

Subjects
LIMBAL stem cells, CORNEA, DRY eye syndromes, CELL separation, COLLAGENASES
Abstract

In ophthalmic research, there is a strong need for in vitro corneal cell models. Here, we describe different protocols for the cultivation of primary corneal cells that were isolated from porcine eyes. This primary cell culture can be used to test new therapeutic options for corneal diseases, such as dry eye disease, traumatic injuries, or corneal infections, and to study limbal epithelial stem cell (LESC) expansion. Two different isolation methods were performed: the outgrowth and the collagenase method. To perform the outgrowth protocol, small explants of the corneal limbus were generated and incubated in culture flasks in an incubator for 4–5 weeks. Regarding the collagenase method, to extract corneal cells, porcine corneas were removed, cut into small pieces, and incubated with collagenase. After incubation and centrifugation, the cells were seeded in 6- or 12-well plates and incubated in an incubator for 2–3 weeks. The differences between corneal cell cultivation with fetal bovine serum (FBS) and without it are also discussed. Therefore, the main advantages of the outgrowth method are that it requires fewer porcine eyes, and it takes less time to be performed compared to the collagenase method. On the other hand, with the collagenase method, mature cells are obtained earlier, at about 2 to 3 weeks. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Management of double-head pterygium with conjunctival autograft and primary closure

Author

Röck, Tobias, Bartz-Schmidt, Karl Ulrich, and Röck, Daniel

Subjects
primary closure, conjunctival autograft transplantation, double-head pterygium, Case Report, sense organs, eye diseases, reconstructive surgical procedures, one-time intervention
Abstract

Purpose Double-headed pterygia are rare and present the surgeon with challenges. This case report illustrates the surgical management and the course of healing in a double-head pterygium patient. Case report A 53-year-old man was referred to our eye hospital with a double-head pterygium of the right eye. During the follow-up examinations, 1 and 3 years later stable findings were found. Five years after initial referral we saw a progression of the double-head pterygium and the patient explained a worse visual acuity. The nasal and temporal pterygium was resected and conjunctival autograft transplantation, and a primary closure was performed, respectively, for the bulbar conjunctival reconstruction. After the surgery, a reduction in the inflammation and healing of the conjunctival lesion could be seen. At the 12-month follow-up, there was no sign of recurrence or any postoperative complication. Conclusion A surgical excision combined with conjunctival autograft transplantation and primary closure in a one-time intervention seems to be effective and economical for the treatment of double-head pterygium.

Published
2020

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