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2. COMPETENCE Trial: The EVAHEART 2 continuous flow left ventricular assist device

Author

Allen, Steven R., Slaughter, Mark S., Ahmed, Mustafa M., Bartoli, Carlo R., Dhingra, Ravi, Egnaczyk, Gregory F., Gulati, Sanjeev K., Kiernan, Michael S., Mahr, Claudius, Meyer, Dan M., Motomura, Tadashi, Ono, Masahiro, Ravichandran, Ashwin, Shafii, Alexis, Smith, Jason, Soleimani, Behzad, Toyoda, Yoshiya, Yarboro, Leora T., and Dowling, Robert D.

Published
2023
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11. Clustering of educational building load data for defining healthy and energy-efficient management solutions of integrated HVAC systems

Author

Testi Daniele, Franco Alessandro, Conti Paolo, and Bartoli Carlo

Subjects
Environmental sciences, GE1-350
Abstract

The COVID-19 pandemic is changing the way individuals, worldwide, feel about staying in public indoor spaces. A strict control of indoor air quality and of people’s presence in buildings will be the new normal, to ensure a healthy and safe environment. Higher ventilation rates with fresh air are expected to be a requirement, especially in educational buildings, due to their high crowding index and social importance. Yet, in this framework, an increased use of primary energy may be overlooked. This paper offers a methodology to efficiently manage complex HVAC systems in educational buildings, concurrently considering the fundamental goals of occupants’ health and energy sustainability. The proposed fourstep procedure includes: dynamic simulation of the building, to generate synthetic energy loads; clustering of the energy data, to identify and predict typical building use profiles; day-ahead planning of energy dispatch, to optimize energy efficiency; dynamic adjustment of air changes, to guarantee a safe indoor air quality. Clustering and forecasting energy needs are expected to become particularly effective in a highly regulated context. The technique has been tested on two university classroom buildings, considering pre-lockdown attendance. This notwithstanding, quality and significance of the obtained thermal energy clusters push towards a benchmark post-pandemic application.

Published
2020
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38. Reply to the Editor

Author

Bartoli, Carlo R., Wead, William B., Giridharan, Guruprasad A., Prabhu, Sumanth D., and Koenig, Steven C.

Published
2012
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46. Toward a Standard Practice to Quantify von Willebrand Factor Degradation During Left Ventricular Assist Device Support.

Author

Hennessy-Strahs, Samson, Bermudez, Christian A., Acker, Michael A., and Bartoli, Carlo R.

Abstract

Continuous-flow left ventricular assist devices (LVADs) cause degradation of von Willebrand factor (VWF) multimers and bleeding. Multiple techniques exist to characterize VWF deficiency. However, a standard methodology has not been established in LVAD patients. Toward this goal, we evaluated 4 methods to quantify VWF multimers. We collected paired blood samples from patients (n = 48) before and after 1 week of LVAD support. After 652 ± 59 days of support, patients were classified as bleeders (≥1 bleeding episode) or nonbleeders. VWF multimers were resolved with electrophoresis and immunoblotting, the gold-standard to evaluate VWF multimers. We evaluated 4 quantification methods. Each method demonstrated significant VWF degradation during LVAD support vs a paired, pre-LVAD sample (method 1, VWF length: 48 of 48 patients, –10% ± 1%, P <.0001; method 2, VWF density: 40 of 48, –34% (interquartile range, –46% to -8%), P <.0001; method 3, pre-LVAD to LVAD ratio: 46 of 48, 17 ± 5: 10 ± 1, P <.0001; method 4, LVAD/pre-LVAD index: 46 of 48, 57% (interquartile range, 50% to 73%), P <.0001). Bleeding occurred in 27 of 48 patients. Method 1 demonstrated significantly fewer VWF multimers in bleeders compared with nonbleeders (–11% ± 1% vs –8% ± 1%; P =.01). Other methods did not demonstrate this potentially important clinical relationship. A standardized methodology is needed to quantify VWF multimer degradation with mechanical circulatory support devices. Novel method 1 successfully quantified the patient-specific change in VWF multimer length during LVAD support and demonstrated a difference in VWF multimers between bleeders and nonbleeders. Adoption of consensus methodology will assist to standardize patient-specific bleeding risk, inform anticoagulation and antiplatelet therapy, and evaluate LVAD hemocompatibility. [ABSTRACT FROM AUTHOR]

Published
2021
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49. Start-up of a large diameter Pulsating Heat Pipe on ground and on board a sounding rocket

Author

Stefano, Piacquadio, Andrea, Catarsi, Nannipieri, Pietro, Martina, Anichini, Lorenzo, Barsocchi, Becatti, Giulia, Luca, Buoni, Federico, Celi, Paolo Di Giorgio, Fattibene, Paolo, Ferrato, Eugenio, Pietro, Guardati, Edoardo, Mancini, Gabriele, Meoni, Federico, Nesti, Edoardo, Pratelli, Lorenzo, Quadrelli, Alessandro Simone Viglione, Francesco, Zanaboni, Mameli, Mauro, Baronti, Federico, Fanucci, Luca, Marcuccio, Salvo, Bartoli, Carlo, DI MARCO, Paolo, Filippeschi, Sauro, Marco La Foresta, Lorenzo, Caporale, Nicola, Bianco, and Marco, Marengo

Subjects
Pulsating Heat Pipe, Start-up, Space, Sounding rocket
Published
2018

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