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2. Tract-specific spinal damage in SCA2, SCA3 and SCA6

Author

de Borba, Fabrício Castro, Fernandes, Joyce Macedo Sanches, de Rezende, Thiago Junqueira Ribeiro, González-Salazar, Carelis, de Melo Teixeira Branco, Lucas, Wolmer, Paulo Schneider, Pedroso, José Luiz, Barsottini, Orlando Graziani Povoas, and França Junior, Marcondes Cavalcante

Published
2025
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3. Further description of the phenotypic spectrum of neuronal ceroid lipofuscinosis type 11

Author

Nóbrega, Paulo Ribeiro, Paiva, Anderson Rodrigues Brandão, Amorim Junior, Antonio Duarte, Lima, Pedro Lucas Grangeiro Sá Barreto, Cabral, Katiane Sayão Souza, Barcelos, Isabella Peixoto, Pessoa, André Luis Santos, Souza-Lima, Carlos Frederico Leite, Castro, Matheus Augusto Araújo, Freua, Fernando, Santos, Emerson de Santana, Rocha, Margleice Marinho Vieira, Maia, Rayana Elias, Araújo, Rodrigo Santos, Ramos, Juan David Guevara, Resende, Rosane Guazi, Carvalho, Gerson da Silva, Valença, Luciana Patrizia Andrade, Lima de Carvalho, José Ronaldo, Jr., Melo, Eduardo Sousa, Pedroso, José Luiz, Barsottini, Orlando Graziani Povoas, Houlden, Henry, Kok, Fernando, and Lynch, David S.

Published
2025
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4. Frequency of anti-MOG antibodies in serum and CSF of patients with possible autoimmune encephalitis: Results from a Brazilian multicentric study

Author

de Freitas Dias, Bruna, Toso, Fabio Fieni, Barreto, Maria Eduarda Slhessarenko Fraife, Dellavance, Alessandra, Thomaz, Rodrigo Barbosa, Kowacs, Pedro André, Teive, Hélio, Spitz, Mariana, Juliano, Aline Freire Borges, Rocha, Letícia Januzi de Almeida, Granja, Valéria Nogueira Tobias, Braga-Neto, Pedro, Nóbrega, Paulo Ribeiro, Oliveira-Filho, Jamary, Dias, Ronaldo Maciel, Amoras, Jaene Andrade Pacheco, Pereira, Renata Brasileiro Reis, Júnior, Clécio de Oliveira Godeiro, Maia, Fernanda Martins, Santos, Mara Lúcia, de Melo, Eduardo Sousa, Júnior, Adaucto Wanderley da Nóbrega, Lin, Katia, Paolilo, Renata Barbosa, Krueger, Mariana Braatz, Barsottini, Orlando Graziani Povoas, Endmayr, Verena, Andrade, Luís Eduardo Coelho, Hoftberger, Romana, and Dutra, Lívia Almeida

Published
2024
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6. Translation, Cross-Cultural Adaptation, and Validation to Brazilian Portuguese of the Cerebellar Cognitive Affective/Schmahmann Syndrome Scale

Author

de Oliveira Scott, Stephanie Suzanne, Pedroso, José Luiz, Elias, Victor Vitalino, Nóbrega, Paulo Ribeiro, Sobreira, Emmanuelle Silva Tavares, de Almeida, Marcela Patrícia, Gama, Maria Thereza Drumond, Massuyama, Breno Kazuo, Barsottini, Orlando Graziani Povoas, Frota, Norberto Anizio Ferreira, and Braga-Neto, Pedro

Published
2023
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9. Combined assessment by transcranial sonography and Sniffin’ Sticks test has a similar diagnostic accuracy compared to brain SPECT for Parkinson's disease diagnosis.

Author

Almeida, Kelson James, Bor-Seng-Shu, Edson, Pedroso, José Luiz, Felicio, Andre Carvalho, de-Lima-Oliveira, Marcelo, Barsottini, Orlando Graziani Povoas, de Carvalho Nogueira, Ricardo, Paschoal-Júnior, Fernando Mendes, Borges, Vanderci, Batista, Ilza Rosa, Teixeira, Manoel Jacobsen, Ferraz, Henrique Ballalai, and Walter, Uwe

Published
2022
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11. Ataxias in Brazil: 17 years of experience in an ataxia center.

Author

Massuyama, Breno Kazuo, Gama, Maria Thereza Drumond, Silva, Thiago Yoshinaga Tonholo, Braga-Neto, Pedro, Pedroso, José Luiz, and Barsottini, Orlando Graziani Povoas

Abstract

Copyright of Arquivos de Neuro-Psiquiatria is the property of Thieme Medical Publishing Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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12. Correction to: Translation, Cross-Cultural Adaptation, and Validation to Brazilian Portuguese of the Cerebellar Cognitive Affective/Schmahmann Syndrome Scale

Author

de Oliveira Scott, Stephanie Suzanne, Pedroso, José Luiz, Elias, Victor Vitalino, Nóbrega, Paulo Ribeiro, Sobreira, Emmanuelle Silva Tavares, de Almeida, Marcela Patrícia, Gama, Maria Thereza Drumond, Massuyama, Breno Kazuo, Barsottini, Orlando Graziani Povoas, Frota, Norberto Anizio Ferreira, and Braga-Neto, Pedro

Published
2023
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16. Clinical and molecular characterization of a large cohort of childhood onset hereditary spastic paraplegias

Author

Giordani, Gabriela Marchisio, Diniz, Fabrício, Fussiger, Helena, Gonzalez-Salazar, Carelis, Donis, Karina Carvalho, Freua, Fernando, Ortega, Roberta Paiva Magalhães, de Freitas, Julian Letícia, Barsottini, Orlando Graziani Povoas, Rosemberg, Sergio, Kok, Fernando, Pedroso, José Luiz, França, Jr, Marcondes Cavalcante, and Saute, Jonas Alex Morales

Published
2021
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18. Cerebrovascular disease in patients with antiphospholipid antibody syndrome: a transcranial Doppler and magnetic resonance imaging study.

Author

Ricarte, Irapuá Ferreira, Dutra, Lívia Almeida, Rodrigues, Daniela Laranja Gomes, Barsottini, Orlando Graziani Povoas, Souza, Alexandre Wagner de, Carrete, Henrique, Massaud, Ana Paula Scalzaretto, Andrade, Danieli, Mangueira, Cristóvão Luís Pitangueira, and Silva, Gisele Sampaio

Subjects
CEREBROVASCULAR disease, PHOSPHOLIPID antibodies, MAGNETIC resonance imaging
Abstract

Objective Transcranial Doppler (TCD) and brain MRI may be useful in evaluating patients with APS, helping to stratify the risk of cerebrovascular ischaemic events in this population. This study aimed to assess the frequency of brain MRI abnormalities in patients with primary antiphospholipid syndrome, secondary antiphospholipid syndrome and SLE and correlate to TCD findings. Methods The study, conducted over four years at two autoimmune disease referral centres, included 22 primary antiphospholipid syndrome patients, 24 secondary antiphospholipid syndrome patients, 27 SLE patients without APS and 21 healthy controls. All participants underwent TCD to assess cerebral haemodynamics, detect microembolic signals and evaluate right-to-left shunts, followed by brain MRI and magnetic resonance angiography. MRI scans were reviewed for acute microembolism, localized cortical infarctions, border infarctions, lacunar infarctions, ischaemic lesions, white matter hyperintensity, micro and macro haemorrhages and arterial stenosis ≥50% of the cervical carotid artery, by two neuroradiologists blinded to the clinical data. Results Brain MRI findings were similar between the groups, except for lacunar infarction, more frequent in patients with secondary antiphospholipid syndrome (P  = 0.022). Patients with intracranial stenosis detected by TCD had a higher frequency of territorial infarction (40% vs 7.5%, P  = 0.02), lacunar (40% vs 11.3%, P  = 0.075) and border zone infarcts (20% vs 1.9%, P  = 0.034). Conclusions Patients with intracranial stenosis presented a higher frequency of territorial, lacunar and border zone infarcts, suggesting that evaluating the intracranial vasculature should not be neglected in patients with APS and stroke. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Metabolic studies of a patient harbouring a novel S487L mutation in the catalytic subunit of AMPK

Author

Arita, Juliana Harumi, Barros, Mário H., Ravagnani, Felipe Gustavo, Ziosi, Marcello, Sanches, Lívia Rentas, Picosse, Fabíola Rosa, Lopes, Tania Oliveira, de Carvalho Aguiar, Patrícia, Macabelli, Carolina Habermann, Chiaratti, Marcos R., Pedroso, José Luiz, Quinzii, Catarina M., Barsottini, Orlando Graziani Póvoas, and Ferreiro-Barros, Claudia Cristina

Published
2018
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20. SPG11 mutations cause widespread white matter and basal ganglia abnormalities, but restricted cortical damage

Author

Faber, Ingrid, Martinez, Alberto Rolim Muro, de Rezende, Thiago Junqueira Ribeiro, Martins, Carlos Roberto, Jr., Martins, Melina Pazian, Lourenço, Charles Marques, Marques, Wilson, Jr., Montecchiani, Celeste, Orlacchio, Antonio, Pedroso, Jose Luiz, Barsottini, Orlando Graziani Povoas, Lopes-Cendes, Íscia, and França, Marcondes Cavalcante, Jr.

Published
2018
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23. Functional ataxia in a specialized ataxia center

Author

Corazza, Luíza Alves, Reis Rosa, Augusto Bragança, Tonholo Silva, Thiago Yoshinaga, Rezende Filho, Flávio Moura, Maranhão-Filho, Péricles Andrade, Pedroso, José Luiz, Barsottini, Orlando Graziani Povoas, and Espay, Alberto J.

Published
2024
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29. What General Neurologists Should Know about Autoinflammatory Syndromes?

Author

de Moraes, Marianna Pinheiro Moraes, do Nascimento, Renan Rodrigues Neves Ribeiro, Abrantes, Fabiano Ferreira, Pedroso, José Luiz, Perazzio, Sandro Félix, and Barsottini, Orlando Graziani Povoas

Subjects
ACUTE phase proteins, NEUROLOGISTS, SYMPTOMS, SYNDROMES, NEUROLOGICAL disorders, AUTOIMMUNE diseases
Abstract

Autoinflammatory disorders encompass a wide range of conditions with systemic and neurological symptoms, which can be acquired or inherited. These diseases are characterized by an abnormal response of the innate immune system, leading to an excessive inflammatory reaction. On the other hand, autoimmune diseases result from dysregulation of the adaptive immune response. Disease flares are characterized by systemic inflammation affecting the skin, muscles, joints, serosa, and eyes, accompanied by unexplained fever and elevated acute phase reactants. Autoinflammatory syndromes can present with various neurological manifestations, such as aseptic meningitis, meningoencephalitis, sensorineural hearing loss, and others. Early recognition of these manifestations by general neurologists can have a significant impact on the prognosis of patients. Timely and targeted therapy can prevent long-term disability by reducing chronic inflammation. This review provides an overview of recently reported neuroinflammatory phenotypes, with a specific focus on genetic factors, clinical manifestations, and treatment options. General neurologists should have a good understanding of these important diseases. [ABSTRACT FROM AUTHOR]

Published
2023
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39. Neurophysiological Studies and Non-Motor Symptoms Prior to Ataxia in a Patient with Machado–Joseph Disease: Trying to Understand the Natural History of Brain Degeneration

Author

Pedroso, José Luiz, Bor-Seng-Shu, Edson, Braga-Neto, Pedro, Ribeiro, Rodrigo Souza, Bezerra, Márcio Luiz Escorcio, do Prado, Lucila B. F., Batista, Ilza Rosa, Alessi, Helena, Teixeira, Manoel Jacobsen, Manzano, Gilberto Mastrocola, do Prado, Gilmar Fernandes, and Barsottini, Orlando Graziani Povoas

Published
2014
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40. History and national survey on reflex hammers: which is the chosen one of Brazilian neurologists?

Author

Dissero, Caio César Diniz, Meira, Alex Tiburtino, Schramm, Carla Caroline, Kondo, Gustavo Koiti, Franklin, Gustavo Leite, Pedroso, José Luiz, Barsottini, Orlando Graziani Povoas, and Teive, Hélio Afonso Ghizoni

Abstract

Background Percussion is an important part of the neurological examination and reflex hammers are necessary to obtain it properly. Objective We aimed to review the historical aspects of the main reflex hammers and to define the favorite one of Brazilian neurologists. Methods We searched original and review articles about historical aspects of the reflex hammers in Scielo and Pubmed and conducted an online survey to investigate the favorite reflex hammer of Brazilian neurologists. Results In the first part, we describe the major milestones in the creation of the reflex hammers. Following, we exhibit the results of the online survey: Babinski-Rabiner was the most voted. Conclusions The origins of the reflex hammers goes back long before their creation, from a basic clinical examination method: percussion. Since the description of deep tendon reflexes and the creation of percussion hammers, much has been improved in this technique. Among all the hammers surveyed, the Babinski-Rabiner was the chosen one by a significant portion of Brazilian neurologists. [ABSTRACT FROM AUTHOR]

Published
2023
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44. Paroxysmal Tonic Upward Gaze: A Clinical Clue for CACNA1A‐Related Disorders.

Author

Massuyama, Breno Kazuo, Tonholo Silva, Thiago Yoshinaga, Gambirasio, Bruna Gutierres, Pedroso, José Luiz, and Barsottini, Orlando Graziani Povoas

Subjects
EPILEPSY, GAZE, NUCLEOTIDE sequencing, MIGRAINE aura, NEUROLOGICAL disorders, SINGLE nucleotide polymorphisms
Abstract

CACNA1A, ataxias, DEE42, epilepsy, neurogenetics In contrast, cryptogenic PTU may have only coordination difficulties during its ictal phase.[10] In conclusion, CACNA1A sequencing should also be considered in the settings of early epilepsy and/or developmental delay when chronic cerebellar signs are present. Keywords: CACNA1A; ataxias; DEE42; epilepsy; neurogenetics EN CACNA1A ataxias DEE42 epilepsy neurogenetics 1225 1227 3 08/29/23 20230801 NES 230801 The gene CACNA1A encodes the a1A pore-forming subunit of the neuronal calcium channel P/Q.[1] CACNA1A-related disorders include the allelic episodic neurological disorders, familial hemiplegic migraine type 1 and episodic ataxia type 2, and the spinocerebellar ataxia type 6, which is a late-onset and progressive cerebellar ataxia. [Extracted from the article]

Published
2023
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50. Neurological complications in patients with SARS-CoV-2 infection: a systematic review

Author

MUNHOZ, Renato Puppi, PEDROSO, José Luiz, NASCIMENTO, Fábio Augusto, ALMEIDA, Sergio Monteiro de, BARSOTTINI, Orlando Graziani Povoas, CARDOSO, Francisco Eduardo C, and TEIVE, Hélio A Ghizoni

Subjects
Stroke, Neurologia, Neurology, Síndrome de Guillain-Barré, Acidente Vascular Cerebral, Guillain-Barré Syndrome, Infecções por Coronavírus, Mialgia, COVID-19, Encephalitis, Encefalopatias, Coronavirus Infections
Abstract

Background: As the COVID-19 pandemic unfolds worldwide, different forms of reports have described its neurologic manifestations. Objective: To review the literature on neurological complications of SARS-CoV-2 infection. Methods: Literature search performed following systematic reviews guidelines, using specific keywords based on the COVID-19 neurological complications described up to May 10th, 2020. Results: A total of 43 articles were selected, including data ranging from common, non-specific symptoms, such as hyposmia and myalgia, to more complex and life-threatening conditions, such as cerebrovascular diseases, encephalopathies, and Guillain-Barré syndrome. Conclusion: Recognition of neurological manifestations of SARS-CoV-2 should be emphasized despite the obvious challenges faced by clinicians caring for critical patients who are often sedated and presenting other concurrent systemic complications. RESUMO Introdução: À medida que a pandemia da COVID-19 se desenvolve em todo o mundo, diferentes tipos de publicações descreveram suas manifestações neurológicas. Objetivo: Revisar a literatura sobre complicações neurológicas da infecção por SARS-CoV-2. Métodos: A pesquisa bibliográfica foi realizada seguindo diretrizes de revisões sistemáticas, usando palavras-chave específicas baseadas nas complicações neurológicas da COVID-19 descritas até 10 de maio de 2020. Resultados: Foram selecionados 43 artigos, incluindo descrições que variam de sintomas comuns e inespecíficos, como hiposmia e mialgia, a condições mais complexas e com risco de vida, como doenças cerebrovasculares, encefalopatias e síndrome de Guillain-Barré. Conclusão: O reconhecimento das manifestações neurológicas da SARS-CoV-2 deve ser enfatizado apesar dos óbvios desafios enfrentados pelos clínicos que cuidam de pacientes críticos, muitas vezes sedados e apresentando outras complicações sistêmicas concomitantes.

Published
2020

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