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1. Citizen science in environmental health research: A comparison with conventional approaches and creation of a guidance tool issued from the LILAS initiative

Author

Laurent, Olivier, Gironza, Yara Carrejo, Ancelet, Sophie, Armant, Olivier, Bard, Denis, Baumgartner, Katia, Bortoli, Sylvie, Boudet, Céline, Chamaret, Philippe, Cormier, Stéphanie, David, Arthur, Desqueyroux, Hélène, Gerber, Mariette, Grimbuhler, Sonia, Mougin, Christian, Payrastre, Laurence, Schraub, Simon, Trousse, Brigitte, Reaud, Cynthia, and Charron, Sylvie

Published
2024
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2. Le projet LILAS : analyse de l’application des approches participatives sur les multi-expositions environnementales et les risques chroniques

Author

Laurent, Olivier, Carrejo Gironza, Yara, Ancelet, Sophie, Armant, Olivier, Bard, Denis, Baumgartner, Katia, Bortoli, Sylvie, Boudet, Céline, Chamaret, Philippe, Chartier, Michel, Cormier, Stéphanie, David, Arthur, Desqueyroux, Hélène, Gerber, Mariette, Gilbin, Rodolphe, Grimbuhler, Sonia, Grison, Stephane, Larqué, Lionel, Laurier, Dominique, Mougin, Christian, Gamet-Payrastre, Laurence, Rannou, Alain, Vanzemberg, Arnaud, Schraub, Simon, Supervil, Sylvie, Thybaud, Eric, Trousse, Brigitte, Charron, Sylvie, Laboratoire d épidémiologie des rayonnements ionisants (IRSN/PSE-SANTE/SESANE/LEPID), Service de recherche sur les effets biologiques et Sanitaires des rayonnements ionisants (IRSN/PSE-SANTE/SESANE), Institut de Radioprotection et de Sûreté Nucléaire (IRSN)-Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Laboratoire d'écotoxicologie des radionucléides (IRSN/PSE-ENV/SRTE/LECO), Service de recherche sur les transferts et les effets des radionucléides sur les écosystèmes (IRSN/PSE-ENV/SRTE), Société francophone de santé environnement (SFSE), France Nature Environnement (FNE), Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire (T3S - UMR_S 1124), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut National de l'Environnement Industriel et des Risques (INERIS), Institut Ecocitoyen pour la Connaissance des Pollutions [Fos-sur-Mer], Service d'expertise et d'étude en radioprotection des populations et de la radioactivité dans l'environnement (IRSN/PSE-ENV/SEREN), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Centre Permanent d'Initiatives pour l'Environnement des Pays de l'Aisne (CPIE des Pays de l'Aisne), EHESP-Irset (EHESP-Irset), École des Hautes Études en Santé Publique [EHESP] (EHESP), Agence de l'Environnement et de la Maîtrise de l'Energie (ADEME), Association nationale des comités et commissions locales d'information [Teteghem] (ANCCLI), Technologies et Méthodes pour les Agricultures de demain (UMR ITAP), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Alliance Sciences-Société, Ecologie fonctionnelle et écotoxicologie des agroécosystèmes (ECOSYS), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Toxicologie Intégrative & Métabolisme (ToxAlim-TIM), ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Pôle Santé Environnement - Direction Santé (IRSN/PSE-SANTE), Service des politiques d’ouverture à la société (IRSN/DST/SPOS), Direction de la Stratégie (IRSN/DST), Service de la programmation, des partenariats, de la prospective et de l’appui à l’innovation (IRSN/DST/SP3IN), Ligue Nationale Contre le Cancer (LNCC), Direction des Risques et de la Performance (IRSN/DRP), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria), IRSN2030, Université de Toulouse (UT)-Ecole d'Ingénieurs de Purpan (INP - PURPAN), Laboratoire d'écotoxicologie des radionucléides (IRSN/PRP-ENV/SERIS/LECO), Service de Recherche et d'Expertise sur les Risques environnementaux (IRSN/PRP-ENV/SERIS), Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Département des sciences en santé environnementale (DEESSE), Information – Technologies – Analyse Environnementale – Procédés Agricoles (UMR ITAP), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro - Montpellier SupAgro, Laboratoire de radiotoxicologie et radiobiologie expérimentale (IRSN/PSE-SANTE/SESANE/LRTOX), ALLISS Sciences Sociétés [Paris], and Ligue Nationale Contre le Cancer - Paris

Subjects
méthodes en santé-environ- multiple exposure, Laboratoire viavant, Méthodes en santé-environnement, multi-expositions, Methods in environmental health research, Analysis tools, co-construction, Multiple exposures, analysis tool, [SDE]Environmental Sciences, participatory research, Living Lab, Grille d'analyse, methods in environmental health, recherches participatives
Abstract

International audience; Context: Participatory research in environmental health remains rare in France. The objectives of environmental health research projects can, like their methods, be very diverse. Opportunities for greater involvement of civil society, as well as its challenges, differ at each step of such research activities. All these aspects need to be widely shared. As a preparatory step toward the development of concrete new participatory research projects on multiple environmental exposures, the LILAS project aimed to (1) favor the mutual understanding of the main issues and research methods in environmental health and their stakes for different participants, but also the requirements, strengths, and limitations of these methods, and (2) identify the expected benefits and points to watch out for related to stronger civic participation in these projects.Methods: The LILAS project identified and gathered together institutional researchers, academics and civil society participants (mainly from nongovernmental organizations) interested in multiple exposures (chemical and radiological). The relevant literature was searched to learn from previous participatory research projects in this broad field. Several meetings enabled the group to collectively identify different types of studies and analyze the benefits, limitations and methods related to the introduction of such participation. An analysis matrix was co-constructed and completed by study participants, as in a Living Lab approach.Results: The matrix lists for different types of studies (assessment of environmental exposures, identification of their determinants, interventions on these exposures, quantitative risk assessment, epidemiological studies, experimental research, ecosystem health, etc.) the expected benefits for several categories of stakeholders, the fundamental principles of research methods, and their related practical constraints, advantages and limitations related to the use of participatory or more standard approaches.Conclusion: The LILAS project enabled the development of a solid basis for the co-construction of participatory research projects to study multiple environmental exposures.; Contexte : Les recherches participatives en santé-environnement restent encore peu développées en France. Les objectifs poursuivis par les recherches en santé-environnement (par exemple : estimer des expositions et/ou des effets, tester des actions préventives) et les méthodes employées à ces fins sont variées. Les opportunités d’une plus grande implication de la société civile et les défis associés diffèrent à chaque étape de ces recherches. Ces aspects demandent à être mieux appréhendés collectivement. Le projet LILAS visait, en amont du développement de futurs projets concrets de recherches participatives sur les multi-expositions environnementales, à (1) favoriser une bonne compréhension commune des principales problématiques et méthodes de recherche en santé-environnement, de leurs enjeux, prérequis, forces et limites, et à (2) identifier les bénéfices et points de vigilance liés à l’introduction de plus fortes dimensions participatives dans ces recherches.Méthode adoptée : Le projet LILAS a identifié et rassemblé des chercheurs institutionnels, académiques et acteurs de la société civile (associations loi 1901) intéressés par les multi-expositions (chimiques, radiologiques). Cinq réunions ont permis d’identifier collectivement différents types d’études et de réfléchir sur les apports, limites et prérequis méthodologiques relatifs à l’introduction de différents degrés de participation dans celles-ci. Une matrice résumant ces aspects a été co-construite puis alimentée par les participants, en s’inspirant des approches Living Lab (soit laboratoire vivant).Résultats : Pour différents types d’études (études d’estimations d’expositions, d’interventions sur celles-ci, évaluations de risques sanitaires, études épidémiologiques, expérimentales, études sur la santé des écosystèmes, etc.), la matrice élaborée en commun liste les bénéfices attendus pour différentes parties prenantes, les principes fondamentaux des méthodes employées et contraintes pratiques associées, les avantages et limites relatifs à l’emploi d’approches participatives (notamment les Living Labs) ou plus « classiques ».Conclusion : Le projet LILAS a permis de poser des bases consolidées pour la co-construction de projets de recherches participatives sur les multi-expositions environnementales.

Published
2022

11. Influence of socioeconomic deprivation on the relation between air pollution and (beta)-agonist sales for asthma

Author

Laurent, Olivier, Pedrono, Gaelle, Filleul, Laurent, Segala, Claire, Lefranc, Agnes, Schillinger, Charles, Riviere, Emmanuel, and Bard, Denis

Subjects
Air pollution -- Health aspects, Air pollution -- Demographic aspects, Asthma -- Demographic aspects, Asthma -- Prognosis, Asthma -- Risk factors, Social economics -- Influence, Social economics -- Health aspects, Health
Published
2009

15. Short-term exposure to ambient air pollution and occurrence of multiple sclerosis relapses

Author

Jeanjean, M., Bind, M. -A., Roux, Jonathan, Ongagna, J. -C., De Seze, J., Bard, Denis, Leray, Emmanuelle, Harvard University [Cambridge], École des Hautes Études en Santé Publique [EHESP] (EHESP), Recherche en Pharmaco-épidémiologie et Recours aux Soins (REPERES), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP), Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), CIC Strasbourg (Centre d’Investigation Clinique Plurithématique (CIC - P) ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Strasbourg (UNISTRA)-Hôpital de Hautepierre [Strasbourg]-Nouvel Hôpital Civil de Strasbourg, EHESP French School of Public Health, Office Of The Director, National Institutes Of Health [DP5OD021412], Novartis, Roche SAS, French ARSEP Foundation, French National Security Agency of Medicines and Health Products, EDMUS Foundation, Jonchère, Laurent, Harvard University, Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nouvel Hôpital Civil de Strasbourg-Hôpital de Hautepierre [Strasbourg]

Subjects
[SDV] Life Sciences [q-bio], Sclerosis, [SDV]Life Sciences [q-bio], Air pollution, ComputingMilieux_MISCELLANEOUS, Exposure
Abstract

International audience

Published
2017

16. Estimating the short-term health impacts of air pollution in populations of divergent socioeconomic deprivation levels: A methodological challenge

Author

Laurent, Olivier, Benichou, Jacques, Pedrono, Gaëlle, Segala, Claire, Filleul, Laurent, Deguen, Séverine, Schillinger, Charles, Rivière, Emmanuel, Bard, Denis, SEPIA-Santé, SEPIA Santé, Cellule Interrégionale d'Epidémiologie (CIRE), Cellule Interregionale d'Epidemiologie (CIRE), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), Association pour la Surveillance et l'Etude la Pollution Atmosphérique en Alsace, Groupe de spectrométrie moléculaire et atmosphérique (GSMA), Université de Reims Champagne-Ardenne (URCA)-Centre National de la Recherche Scientifique (CNRS), Université d'Angers (UA)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
Méthodologie, Evaluation du risque, Exposition environnementale, [SDV]Life Sciences [q-bio], Facteurs socioéconomiques, Methodology, Socioeconomic factors, Environmental exposure, Risk assessment
Abstract

International audience; It is increasingly suspected that the health impact of air pollution may be greateramong socioeconomically disadvantaged populations than among those who are betteroff. However, health impact assessments of air pollution generally do not takesocioeconomic status into account. In this paper, we propose an approach to thequantitative estimation of the short-term impacts of environmental risk factors such as airpollution among socioeconomically contrasted populations. We do so through anillustrative case study of ambient air pollution and emergency calls for asthma attacks inStrasbourg (France). Next, we discuss the potential advantages of this approach as well asits current limitations, and then look at the research needs that must be addressed toimprove its applicability. Among these, the most urgent appear to be the needs forimproved exposure estimates and for large-scale epidemiological studies that useharmonized methods to investigate the modification by socioeconomic status and otherfactors of the effects of air pollution. Case-crossover designs offer promisingperspectives for that purpose, especially as more accurate and individualized estimatesof air pollution exposure become available for epidemiological studies; On suspecte de plus en plus que l’ampleur des impacts sanitaires de la pollution atmosphérique augmente à mesure que le niveau socio-économique des populations décroît. Cependant, à ce jour, les évaluations d’impacts sanitaires de la pollution atmosphérique n’intègrent en général pas la dimension socio-économique. Dans cet article, une approche est proposée pour estimer quantitativement les effets à court terme de la pollution atmosphérique au sein de populations présentant des niveaux socio-économiques contrastés. Cette approche est illustrée par une application aux appels d’urgence pour crises d’asthme dans la communauté urbaine de Strasbourg. Les avantages de l’approche proposée y sont discutés, ainsi que les limites actuelles à son application. Des axes de recherche à développer pour améliorer son applicabilité sont identifiés. Parmi ceux-ci, l’amélioration de l’estimation des expositions à la pollution atmosphérique ainsi que la réalisation d’études multicentriques de grande ampleur, employant des méthodologies harmonisées afin d’étudier simultanément les interactions par le niveau socio-économique et par d’autres facteurs apparaissent de première importance. Le schéma d’étude cas-croisés offre des perspectives prometteuses pour répondre à cet objectif. Il permettra en particulier de prendre en compte à l’échelle individuelle des indicateurs d’exposition de plus en plus fins, au fur et à mesure que ceux-ci deviendront disponibles pour des études épidémiologiques.

Published
2012

18. Human exposure to lifestyle-related ultrafine particles in domestic environment

Author

Ji, Xiaolin, Mandin, Corinne, Le Bihan, Olivier, Ramalho, Olivier, Martinon, Laurent, Larbre, Juliette, Bard, Denis, Pairon, Jean-Claude, Institut National de l'Environnement Industriel et des Risques (INERIS), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-IFR10, Centre Scientifique et Technique du Bâtiment (CSTB), École des Hautes Études en Santé Publique [EHESP] (EHESP), Civs, Gestionnaire, and Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)

Subjects
[SDE] Environmental Sciences, Ultrafine particles, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDE]Environmental Sciences, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Domestic environment
Published
2010

19. Measuring levels of ultrafine particle concentrations in residential environment - NANOP Projet

Author

Ji, Xiaolin, Le Bihan, Olivier, Mandin, Corinne, Ramalho, Olivier, Martinon, Laurent, Larbre, Juliette, Bard, Denis, Pairon, Jean-Claude, Institut National de l'Environnement Industriel et des Risques (INERIS), Centre Scientifique et Technique du Bâtiment (CSTB), École des Hautes Études en Santé Publique [EHESP] (EHESP), Faculté de Médecine, Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), and Civs, Gestionnaire

Subjects
[SDE] Environmental Sciences, Ultrafine particle concentrations, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDE]Environmental Sciences, Residential environment, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, NANOP Projet
Published
2010

20. A novel approach for characterizing neighbourhood deprivation

Author

Kihal, Wahida, Pédrono, Gaëlle, Weber, Christiane, Bard, Denis, Laboratoire Image, Ville, Environnement [Strasbourg] (LIVE), Université de Strasbourg (UNISTRA), Epidémiologie et Biostatistique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), ENSP, École des Hautes Études en Santé Publique [EHESP] (EHESP), and Schlumberger, Rosine

Subjects
[SHS.GEO] Humanities and Social Sciences/Geography, neighbourhood deprivation, [SHS.GEO]Humanities and Social Sciences/Geography
Published
2010

21. Ambient Air Pollution, Social Inequalities and Asthma Exacerbation in Greater Strasbourg (France) Metropolitan Area: the PAISA Study

Author

Bard, Denis, Laurent, Olivier, Havard, Sabrina, Deguen, Séverine, Pedrono, Gaelle, Filleul, Laurent, Segala, Claire, Lefranc, Agnes, Schillinger, Charles, Riviere, Emmanuel, École des Hautes Études en Santé Publique [EHESP] (EHESP), Laboratoire Magmas et Volcans (LMV), Institut national des sciences de l'Univers (INSU - CNRS)-Université Jean Monnet [Saint-Étienne] (UJM)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Observatoire de Physique du Globe de Clermont-Ferrand (OPGC), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'étude et de recherche en environnement et santé (LERES), Institut de recherche en santé, environnement et travail (Irset), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA), Département Méthodes quantitatives en santé publique (METIS), SEPIA-Santé, Cellule Interrégionale d'Epidémiologie (CIRE), Cellule Interregionale d'Epidemiologie (CIRE), SEPIA Santé, Association pour la Surveillance et l'Etude la Pollution Atmosphérique en Alsace, Groupe de spectrométrie moléculaire et atmosphérique (GSMA), Université de Reims Champagne-Ardenne (URCA)-Centre National de la Recherche Scientifique (CNRS), Vanda Villanyi, Jonchère, Laurent, Observatoire de Physique du Globe de Clermont-Ferrand (OPGC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), and Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
[SDV] Life Sciences [q-bio], [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, immune system diseases, Social Inequalities, Air Pollution, Strasbourg, [SDV]Life Sciences [q-bio], PAISA Study, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Asthma, respiratory tract diseases
Abstract

International audience; The socio-economic status (SES) of populations has an influence on the incidence or mortality rates of numerous health outcomes, among which respiratory diseases (Prescott et al., 2003; Ellison-Loschmann et al., 2007). Considering asthma, the possible contribution of SES to overall prevalence –regardless of asthma severity-, remains controversial in industrialized countries. Several studies indicate that allergic asthma is more prevalent in more well-off populations whereas the non-allergic forms of asthma are more common in the deprived ones (Cesaroni et al., 2003; Blanc et al., 2006). On the other hand, severe asthma whatever its etiology appears to be more frequent in the latter populations, as compared to the more affluent (Basagana et al., 2004). Risk factors for exacerbations (e.g., passive smoking (Wright Subramanian, 2007), psychosocial stress (Gold & Wright, 2005), cockroach allergens (Kitch et al., 2000), and suboptimal compliance with anti-inflammatory medication (Gottlieb et al., 1995)) are generally more common among people with asthma and low SES than their better-off counterparts. These observations support the hypothesis that some factors more present in deprived populations contribute to asthma exacerbation (Mielck et al., 1996).

Published
2010

22. Air Pollution and Myocardial Infarction - a Small-Area Case Crossover in Strasbourg, France Influence of Individual and Area Characteristics

Author

Havard, Sabrina, Pédrono, Gaëlle, Deguen, Séverine, Schillinger, Charles, Segala, Claire, Rivière, Emmanuel, Arveiler, Dominique, Bard, Denis, Groupe d'Etude de la Reproduction Chez l'Homme et les Mammiferes (GERHM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Epidémiologie et Biostatistique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Association pour la Surveillance et l'Étude de la Pollution atmosphérique en Alsace (ASPA), Agence de surveillance de la qualité de l’air (ASPA), Faculté de médecine (EA1801), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), and ENSP Rennes

Subjects
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2008

23. Exposure to nanoparticles in residential environment

Author

Ji, Xiaolin, Mandin, Corinne, Ramalho, Olivier, Le Bihan, Olivier, Martinon, Laurent, Bard, Denis, Pairon, Jean-Claude, Institut National de l'Environnement Industriel et des Risques (INERIS), Centre Scientifique et Technique du Bâtiment (CSTB), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Laboratoire d'Etude des Particules Inhalées (LEPI), Ville de Paris, ENSP, École des Hautes Études en Santé Publique [EHESP] (EHESP), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Pneumologie et Pathologie Professionnelle, CHI Créteil, Institut Interuniversitaire de Médecine du Travail de Paris-Ile de France, Université Biomédicale des Saints-Pères, and Ramalho, Olivier

Subjects
[SDE] Environmental Sciences, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDE]Environmental Sciences, Residential environment, Nanoparticles, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, ComputingMilieux_MISCELLANEOUS, Exposure
Abstract

International audience

Published
2008

24. Measuring levels, assessing determinants and variabilities of nanoparticle concentrations in residential environment, the NANOP project

Author

Ji, Xiaolin, Mandin, Corinne, Ramalho, Olivier, Le Bihan, Olivier, Martinon, Laurent, Pairon, Jean-Claude, Bard, Denis, Ramalho, Olivier, Institut National de l'Environnement Industriel et des Risques (INERIS), Institut Mondor de recherche biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Centre Scientifique et Technique du Bâtiment (CSTB), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Laboratoire d'Etude des Particules Inhalées (LEPI), Ville de Paris, ENSP, and École des Hautes Études en Santé Publique [EHESP] (EHESP)

Subjects
[SDE] Environmental Sciences, Nanoparticle concentrations, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDE]Environmental Sciences, Residential environment, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, NANOP project
Abstract

International audience; Non engineered nanoparticles (NP), also called ultrafine particles (∅ < 100 nm), have numerous sources in the atmosphere as well as indoors (e.g. traffic, cooking...). To date studies on NP levels in ambient and indoor air are scarce. The NANOP project aims at assessing nanoparticle levels and their spatial and temporal variation in a domestic environment. The study is carried out in an experimental and fully controlled house.

Published
2008

25. Exploring the joint effect of atmospheric pollution and socioeconomic status on selected health outcomes: the PAISARC Project

Author

Bard, Denis, Laurent, O., Filleul, Laurent, Havard, Sabrina, Deguen, Séverine, Segala, Claire, Pédrono, Gaëlle, Riviére, E., Schillinger, Charles, Rouil, L., Arveiler, D., Eilstein, D., École des Hautes Études en Santé Publique [EHESP] (EHESP), Cire Aquitaine, Institut de Veille Sanitaire (INVS), Groupe d'Etude de la Reproduction Chez l'Homme et les Mammiferes (GERHM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Epidémiologie et Biostatistique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Association pour la Surveillance et l'Étude de la Pollution atmosphérique en Alsace (ASPA), Agence de surveillance de la qualité de l’air (ASPA), Institut National de l'Environnement Industriel et des Risques (INERIS), and Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, Myocardial infarction, Small area, Air pollution, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Socioeconomic factors, Asthma, Analysis
Abstract

International audience; Health socioeconomic gradients are well documented in developed countries, but incompletely explained. A portion of these health inequalities may be explained by environmental exposures. The objective of PAISARC is to explore the relations between socioeconomic status, air pollution exposure and two selected health outcomes--asthma exacerbations and myocardial infarction--at the level of a small area. The study design is ecological, using data available from the national census, with the residential block (French IRIS, 2000 people on average, National Institute of Statistics--INSEE) as the statistical unit. The setting is the Greater Strasbourg metropolitan area (450 000 inhabitants) in eastern France. We first constructed a socioeconomic status index, using 1999 national census data and principal component analysis at the resolution of these census blocks. Air pollution data were then modeled at the same resolution on an hourly basis for the entire study period (2000-2005). Health data were obtained from various sources (local emergency networks, the local population-based coronary heart disease registry, health insurance funds) according to the health outcome. We present here the initial results and discuss the methodological approaches best suited for the forthcoming steps of our project.

Published
2007

26. Measuring levels, assessing determinants and variabilities of nanoparticles concentrations in residential environment, The NANOP Project

Author

Mandin, Corinne, Ramalho, Olivier, Le Bihan, Olivier, Pairon, Jean-Claude, Martinon, Laurent, Bard, Denis, Institut National de l'Environnement Industriel et des Risques (INERIS), Centre Scientifique et Technique du Bâtiment (CSTB), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Pneumologie et Pathologie Professionnelle, CHI Créteil, Institut Interuniversitaire de Médecine du Travail de Paris-Ile de France, Université Biomédicale des Saints-Pères, Laboratoire d'Etude des Particules Inhalées (LEPI), Ville de Paris, ENSP, École des Hautes Études en Santé Publique [EHESP] (EHESP), and Ramalho, Olivier

Subjects
[SDE] Environmental Sciences, [SDE]Environmental Sciences
Abstract

International audience; The NANOP project aims at assessing nanoparticle levels and their spatial and temporal variation in domestic environment simulated within an experimental house (MARIA) based at the Building Technical and Scientific Center (CSTB), i.e. a fully controlled domestic environment (as regards air exchange, heating...). Possible relations between different metrics such as particle number, mass, specific surface, size distribution should be identified. Respective contributions of indoor sources to exposure, but also from outdoor air will be determined.

Published
2007

27. Qualité de l'air à Nouméa et santé respiratoire des écoliers Une étude de panel.

Author

BARD, DENIS, LAUMOND, SYLVIE, LE PLOMB, ERIC, HATTERMANN, LOÏC, SEGALA, CLAIRE, and RIVIÈRE, EMMANUEL

Abstract

Copyright of Environnement, Risques & Santé is the property of John Libbey Eurotext Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2017
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28. Air pollution by particulate matter PM10 may trigger multiple sclerosis relapses.

Author

Roux, Jonathan, Bard, Denis, Le Pabic, Estelle, Segala, Claire, Reis, Jacques, Ongagna, Jean-Claude, de Sèze, Jérôme, and Leray, Emmanuelle

Subjects
*MULTIPLE sclerosis, *AIR pollution, *PARTICULATE matter, *OXIDATIVE stress, *CONFIDENCE intervals, *PATIENTS
Abstract

Background Seasonal variation of relapses in multiple sclerosis (MS) suggests that season-dependent factors, such as ambient air pollution, may trigger them. However, only few studies have considered possible role of air pollutants as relapse's risk factor. Objective We investigated the effect of particulate matter of aerodynamic diameter smaller than 10 µm (PM 10 ) on MS relapses. Methods In total, 536 relapsing MS patients from Strasbourg city (France) were included, accounting for 2052 relapses over 2000–2009 period. A case-crossover design was used with cases defined as the days of relapse and controls being selected in the same patient at plus and minus 35 days. Different lags from 0 to 30 days were considered. Conditional logistic regressions, adjusted on meteorological parameters, school and public holidays, were used and exposure was considered first as a quantitative variable and second, as a binary variable. Results The natural logarithm of the average PM 10 concentration lagged from 1 to 3 days before relapse onset was significantly associated with relapse risk (OR =1.40 [95% confidence interval 1.08–1.81]) in cold season. Consistent results were observed when considering PM 10 as a binary variable, even if not significant. Conclusion With an appropriate study design and robust ascertainment of neurological events and exposure, the present study highlights the effect of PM 10 on the risk of relapse in MS patients, probably through oxidative stress mechanisms. [ABSTRACT FROM AUTHOR]

Published
2017
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29. Developing a data-driven spatial approach to assessment of neighbourhood influences on the spatial distribution of myocardial infarction.

Author

Kihal-Talantikite, Wahida, Weber, Christiane, Pedrono, Gaelle, Segala, Claire, Arveiler, Dominique, Sabel, Clive E., Deguen, Séverine, and Bard, Denis

Subjects
SPATIAL distribution (Quantum optics), MYOCARDIAL infarction treatment, SOCIOECONOMIC factors, MEDICAL geography, SOCIAL cohesion
Abstract

Background: There is a growing understanding of the role played by 'neighbourhood' in influencing health status. Various neighbourhood characteristics—such as socioeconomic environment, availability of amenities, and social cohesion, may be combined—and this could contribute to rising health inequalities. This study aims to combine a data-driven approach with clustering analysis techniques, to investigate neighbourhood characteristics that may explain the geographical distribution of the onset of myocardial infarction (MI) risk. Methods: All MI events in patients aged 35–74 years occurring in the Strasbourg metropolitan area (SMA), from January 1, 2000 to December 31, 2007 were obtained from the Bas-Rhin coronary heart disease register. All cases were geocoded to the census block for the residential address. Each areal unit, characterized by contextual neighbourhood profile, included socioeconomic environment, availability of amenities (including leisure centres, libraries and parks, and transport) and psychosocial environment as well as specific annual rates standardized (per 100,000 inhabitants). A spatial scan statistic implemented in SaTScan was then used to identify statistically significant spatial clusters of high and low risk of MI. Result: MI incidence was non-randomly spatially distributed, with a cluster of high risk of MI in the northern part of the SMA [relative risk (RR) = 1.70, p = 0.001] and a cluster of low risk of MI located in the first and second periphery of SMA (RR 0.04, p value = 0.001). Our findings suggest that the location of low MI risk is characterized by a high socioeconomic level and a low level of access to various amenities; conversely, the location of high MI risk is characterized by a high level of socioeconomic deprivation—despite the fact that inhabitants have good access to the local recreational and leisure infrastructure. Conclusion: Our data-driven approach highlights how the different contextual dimensions were inter-combined in the SMA. Our spatial approach allowed us to identify the neighbourhood characteristics of inhabitants living within a cluster of high versus low MI risk. Therefore, spatial data-driven analyses of routinely-collected data georeferenced by various sources may serve to guide policymakers in defining and promoting targeted actions at fine spatial level. [ABSTRACT FROM AUTHOR]

Published
2017
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30. Avantages pour la santé publique de la conformité aux normes d'émissions actuelles de l'UE pour un incinérateur de déchets municipaux

Author

Glorennec, Philippe, Bard, Denis, Zmirou, Denis, Groupe d'Etude de la Reproduction Chez l'Homme et les Mammiferes (GERHM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), ENSP Rennes, Brébion, Alice, and Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Dioxin, Health risk assessment, Waste incineration, E.U. emissions standards, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Public Health, Multimedia model, Benefits, Compliance
Published
2004

31. Current lead exposure of French infants and toddlers may put them at risk of impaired neurobehavioural and cognitive development

Author

Bard, Denis, Savy, O., Hivert, G., Coquet, S., Glorennec, Philippe, ENSP Rennes, Groupe d'Etude de la Reproduction Chez l'Homme et les Mammiferes (GERHM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Brébion, Alice, and Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, Lead exposure, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.EE.SANT] Life Sciences [q-bio]/Ecology, environment/Health, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, Children
Published
2002

32. Traffic-Related Air Pollution and the Onset of Myocardial Infarction: Disclosing Benzene as a Trigger? A Small-Area Case-Crossover Study.

Author

Bard, Denis, Kihal, Wahida, Schillinger, Charles, Fermanian, Christophe, Ségala, Claire, Glorion, Sophie, Arveiler, Dominique, and Weber, Christiane

Subjects
*MYOCARDIAL infarction, *AIR pollution, *BENZENE, *POLLUTION, *PARTICULATE matter, *GASOLINE, *PUBLIC health
Abstract

Background and Objectives: Exposure to traffic is an established risk factor for the triggering of myocardial infarction (MI). Particulate matter, mainly emitted by diesel vehicles, appears to be the most important stressor. However, the possible influence of benzene from gasoline-fueled cars has not been explored so far. Methods and Results: We conducted a case-crossover study from 2,134 MI cases recorded by the local Coronary Heart Disease Registry (2000–2007) in the Strasbourg Metropolitan Area (France). Available individual data were age, gender, previous history of ischemic heart disease and address of residence at the time of the event. Nitrogen dioxide, particles of median aerodynamic diameter <10 µm (PM10), ozone, carbon monoxide and benzene air concentrations were modeled on an hourly basis at the census block level over the study period using the deterministic ADMS-Urban air dispersion model. Model input data were emissions inventories, background pollution measurements, and meteorological data. We have found a positive, statistically significant association between concentrations of benzene and the onset of MI: per cent increase in risk for a 1 µg/m3 increase in benzene concentration in the previous 0, 0–1 and 1 day was 10.4 (95% confidence interval 3–18.2), 10.7 (2.7–19.2) and 7.2 (0.3–14.5), respectively. The associations between the other pollutants and outcome were much lower and in accordance with the literature. Conclusion: We have observed that benzene in ambient air is strongly associated with the triggering of MI. This novel finding needs confirmation. If so, this would mean that not only diesel vehicles, the main particulate matter emitters, but also gasoline-fueled cars –main benzene emitters–, should be taken into account for public health action. [ABSTRACT FROM AUTHOR]

Published
2014
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34. Massive overfeeding and energy balance in men: the Guru Walla model.

Author

Pasquet, Patrick, Brigant, Lucienne, Froment, Alain, Koppert, Georgius A., Bard, Denis, de Garine, Igor, and Apfelbaum, Marian

Subjects
HYPERPHAGIA, BIOENERGETICS, FOOD consumption, BODY weight, HUMAN body composition, CALORIC expenditure
Abstract

To determine the magnitude of the thermogenic response to a massive long-term overfeeding, an energy-balance study was carried out in nine lean, young Cameroonian men participating in a traditional fattening session: the Guru Walla. Food intake, body weight, body composition, activity, and metabolic rates were recorded during a 10-d baseline period and over the 6 1-65 d of fattening. Total energy expenditure (TEE) was measured by using doubly labeled water during the baseline period and the final 10 d of Guru Walla. Cumulative overfeeding consisted of 955 ± 252 MJ (¯ ± SD) mainly as carbohydrate. Body-weight increase was 17 ± 4 kg, 64-75% as fat. Metabolic rates increased but TEE did not. However, when accounting for the reduction in physical activity, substantial thermogenesis was observed but its amplitude was not greater than that observed under less extreme carbohydrate-overfeeding conditions. If luxuskonsumption does exist, it is not related to the magnitude of the cumulative overfeeding. [ABSTRACT FROM AUTHOR]

Published
1992
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39. Ozone, NO2 and PM10 are associated with the occurrence of multiple sclerosis relapses. Evidence from seasonal multi-pollutant analyses.

Author

Jeanjean, Maxime, Bind, Marie-Abele, Roux, Jonathan, Ongagna, Jean-Claude, de Sèze, Jérôme, Bard, Denis, and Leray, Emmanuelle

Subjects
*MULTIPLE sclerosis, *DISEASE relapse, *PHYSIOLOGICAL effects of ozone, *PHYSIOLOGICAL effects of nitrogen oxides, *LOGISTIC regression analysis
Abstract

Background Triggers of multiple sclerosis (MS) relapses are essentially unknown. PM 10 exposure has recently been associated with an increased risk of relapses. Objectives We further explore the short-term associations between PM 10 , NO 2 , benzene (C 6 H 6 ), O 3 , and CO exposures, and the odds of MS relapses’ occurrence. Methods Using a case-crossover design, we studied 424 MS patients living in the Strasbourg area, France between 2000 and 2009 (1783 relapses in total). Control days were chosen to be ± 35 days relative to the case (relapse) day. Exposure was modeled through ADMS-Urban software at the census block scale. We consider single-pollutant and multi-pollutant conditional logistic regression models coupled with a distributed-lag linear structure, stratified by season ("hot" vs. "cold"), and adjusted for meteorological parameters, pollen count, influenza-like epidemics, and holidays. Results The single-pollutant analyses indicated: 1) significant associations between MS relapse incidence and exposures to NO 2 , PM 10 , and O 3 , and 2) seasonality in these associations. For instance, an interquartile range increase in NO 2 (lags 0–3) and PM 10 exposure were associated with MS relapse incidence (OR = 1.08; 95%CI: [1.03–1.14] and OR = 1.06; 95%CI: [1.01–1.11], respectively) during the "cold" season (i.e., October-March). We also observed an association with O 3 and MS relapse incidence during "hot" season (OR = 1.16; 95%CI: [1.07–1.25]). C 6 H 6 and CO were not significantly related to MS relapse incidence. However, using multi-pollutant models, only O 3 remained significantly associated with the odds of relapse triggering during "hot" season. Conclusion We observed significant single-pollution associations between the occurrence of MS relapses and exposures to NO 2 , O 3 and PM 10 , only O 3 remained significantly associated with occurrence of MS relapses in the multi-pollutant model. [ABSTRACT FROM AUTHOR]

Published
2018
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40. Probabilistic modeling of young children's overall lead exposure in France: Integrated approach for various exposure media

Author

Glorennec, Philippe, Bemrah, Nawel, Tard, Alexandra, Robin, Alban, Bot, Barbara Le, and Bard, Denis

Subjects
*LEAD & the environment, *HAZARDOUS substance exposure, *LEAD poisoning in children, *LEAD content of drinking water, *LEAD in soils, *TOXIC substance exposure
Abstract

Objectives: Emissions of lead into the environment (and thus its environmental concentrations) have decreased in recent years. We sought to estimate the overall lead exposure of children aged 6 months to 6 years (the population group most exposed and most sensitive to lead) in France through the various media (air, food, water, soils, and dust) and the respective contributions of each medium to the total dose. We have focused on the general population, leaving aside specific risk factors such as deteriorated lead paints. Methods: We used the most recent French intake data for food and water, and a daily ingested quantity selected from the literature for soils and dust. Contamination data came from the first total diet study of contaminant levels in France (2000–2001), from regulatory testing of tap water (2004), a literature review of lead in urban soils, and a pilot study (2005) of lead in dust. Air quality monitoring measurements showed that the contribution of air could now be safely ignored. Weekly exposure doses were estimated with Monte Carlo simulations. Results: Median weekly exposure dose was 7.5 μg/kg bw.week for children aged 6 months to 3 years and 4.7 for those aged from 3–6 years. 95th percentiles were 13.5 and 8.7 μg/kg bw.week. Exposure came mainly from food. The principal uncertainties are associated with quantification limits in food and water, representativeness and traceability of tap water samples, and absence of recent data about urban soil contamination. Conclusions: These results differ quite notably from earlier estimates and highlight the need, especially for policy-making purposes, to update exposure measurements for this metal. [Copyright &y& Elsevier]

Published
2007
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41. Environmental disasters: preparing for impact assessments and operational feedback.

Author

Verger P, Bard D, Noiville C, and Lahidji R

Subjects
Civil Defense organization & administration, Disasters classification, France, Health Planning Guidelines, Humans, Risk Management, Disaster Planning organization & administration, Disasters prevention & control, Feedback, Needs Assessment
Abstract

On March 24, 2006, the French Minister of Environment asked the Committee for Prevention and Precaution (CPP), an independent multidisciplinary committee created in 1996, to conduct a methodological analysis of operational feedback of natural and technological disasters to determine if France is equipped to collect the information and data necessary for the assessment, and optimal management of a disaster and its consequences. The Committee's analysis was based on the testimony it heard from 13 experts--scientists and representatives of associations and advocacy groups--and its review of the literature, including operational feedback reports. Its response to the Minister focused on the assessment of the health, social, environmental, and economic impacts of disasters and on their operational feedback (defined as the systematic analysis of a past event to draw lessons for the management of the risk), as practiced in France. It presents the results of the literature review about the consequences of disasters, expert's views on the current utility and limitations of impact assessments and operational feedback, the CPP's discussion of these results, and its recommendations to improve impact assessment and operational feedback of disasters. These recommendations cover preparation for and activation of data collection and operational feedback, financial provisions, coordination of stakeholders, education and training in disaster preparedness, and the distribution and use of data from operational feedback.

Published
2008

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