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298 results on '"Balestra, C."'

8. As-bearing new mineral species from Valletta mine, Maira Valley, Piedmont, Italy: IV. Lombardoite, Ba2Mn3+(AsO4)(2)(OH) and aldomarinoite, Sr2Mn3+(AsO4)(2)(OH), description and crystal structure

Author

Camara, F, Baratelli, L, Ciriotti, Me, Nestola, F, Piccoli, Gc, Bosi, F, Bittarello, E, Halenius, U, and Balestra, C

Subjects
manganese arsenate, aldomarinoite, crystal structure, lombardoite, new mineral, Raman spectroscopy, infrared spectroscopy, brackebuschite supergroup, Valletta mine, Cuneo, Piedmont, Italy
Published
2022

13. Early Endothelial Dysfunction in Type 1 Diabetes Is Accompanied by an Impairment of Vascular Smooth Muscle Function:A Meta-Analysis

Author

Lespagnol, E. (Elodie), Dauchet, L. (Luc), Pawlak-Chaouch, M. (Mehdi), Balestra, C. (Costantino), Berthoin, S. (Serge), Feelisch, M. (Martin), Roustit, M. (Matthieu), fontaine, P. (pierre), Heyman, E. (Elsa), Université de Lille, Univ. Artois, Univ. Littoral Côte d’Opale, Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 [URePSSS], Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE], Haute Ecole de Bruxelles [HE2B], University of Southampton, and Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 [EGENODIA (GI3M)]

Subjects
endothelial function, exercise, macrocirculation, microcirculation, peripheral vascular disease, smooth muscle function, type 1 diabetes
Abstract

A large yet heterogeneous body of literature exists suggesting that endothelial dysfunction appears early in type 1 diabetes, due to hyperglycemia-induced oxidative stress. The latter may also affect vascular smooth muscles (VSM) function, a layer albeit less frequently considered in that pathology. This meta-analysis aims at evaluating the extent, and the contributing risk factors, of early endothelial dysfunction, and of the possible concomitant VSM dysfunction, in type 1 diabetes. PubMed, Web of Sciences, Cochrane Library databases were screened from their respective inceptions until October 2019. We included studies comparing vasodilatory capacity depending or not on endothelium (i.e., endothelial function or VSM function, respectively) in patients with uncomplicated type 1 diabetes and healthy controls. Fifty-eight articles studying endothelium-dependent function, among which 21 studies also assessed VSM, were included. Global analyses revealed an impairment of standardized mean difference (SMD) (Cohen's d) of endothelial function: -0.61 (95% CI: -0.79, -0.44) but also of VSM SMD: -0.32 (95% CI: -0.57, -0.07). The type of stimuli used (i.e., exercise, occlusion-reperfusion, pharmacological substances, heat) did not influence the impairment of the vasodilatory capacity. Endothelial dysfunction appeared more pronounced within macrovascular than microvascular beds. The latter was particularly altered in cases of poor glycemic control [HbA > 67 mmol/mol (8.3%)]. This meta-analysis not only corroborates the presence of an early impairment of endothelial function, even in response to physiological stimuli like exercise, but also highlights a VSM dysfunction in children and adults with type 1 diabetes. Endothelial dysfunction seems to be more pronounced in large than small vessels, fostering the debate on their relative temporal appearance. 11

Published
2020

25. Effect of corrosion degree on mechanical properties of reinforcements buried for 60 years

Author

BALESTRA, C. E. T., LIMA, M. G., MENDES, A. Z., and MEDEIROS-JUNIOR, R. A.

Subjects
smallest diameter, menor diâmetro, corrosão de armaduras, propriedades mecânicas, reinforcement corrosion, corrosion degree, grau de corrosão, durability, durabilidade, mechanical properties, mass loss, perda de massa
Abstract

This paper studies the influence of the corrosion degree calculated by the mass loss and by the smaller diameters on the yield strength, ultimate strength and final elongation. Reinforcements buried and naturally corroded for 60 years were studied. The mechanical properties of the protruding reinforcing steel were compared to reference bars, which also remained buried for 60 years, but without going through the corrosion process. Micrographs, besides the chemical composition and the characterization of the aggressiveness of the soil were realized. The micrographs and the chemical composition show the presence of pits in the reinforcements and sulfur contents for steel above the prescriptions of the time when the foundations were initially implement, respectively. The results also show that the effects of pitting corrosion on the mechanical properties of the naturally corroded bars may not be adequately expressed by the mass loss. This type of corrosion (pits) produces geometric variations in the cross sections along the length of the test specimens, generating stress gradients between successive sections. This has a noticeable impact on the mechanical properties of the reinforcements. In general, the effects of corrosion are more pronounced on the ductility of the reinforcement. Regarding the aggressiveness of the soil, high corrosion rates were identified in the reinforcement, even with the soil being classified as essentially non-corrosive. Resumo Este artigo estuda a influência do grau de corrosão, calculado pela perda de massa e pelos menores diâmetros, sobre a resistência ao escoamento, limite de resistência e alongamento final em armaduras corroídas naturalmente. Essas armaduras permaneceram enterradas por 60 anos. As propriedades mecânicas das armaduras de espera foram comparadas às de barras de referência, que também permaneceram enterradas por 60 anos, mas sem sofrer o processo de corrosão. Foram realizadas micrografias, além da determinação da composição química e da caracterização da agressividade do solo onde as armaduras estavam enterradas. As micrografias e a composição química mostram a presença de pites nas armaduras e teores de enxofre acima das prescrições recomendadas para o aço na época de execução das fundações, respectivamente. Os resultados também mostram que os efeitos da corrosão por pites sobre as propriedades mecânicas das barras corroídas naturalmente podem não ser adequadamente expressos pela perda de massa. Esse tipo de corrosão (pites) produz variações geométricas nas seções transversais ao longo do comprimento dos corpos de prova, gerando gradientes de esforços entre seções sucessivas, que impactam de forma notória sobre suas propriedades mecânicas. De uma maneira geral, os efeitos da corrosão são mais pronunciáveis sobre a ductilidade das barras. Com relação à agressividade do solo, altas velocidades de corrosão foram identificadas nas armaduras, mesmo com o solo sendo classificado como essencialmente não corrosivo.

Published
2018

26. From Breath-hold diving to patient's bed : The normobaric oxygen paradox

Author

Balestra, C.

Abstract

There is a great concern regarding the increased need for blood products in an aging population and the cost of safe blood transfusion in developing countries. The use of blood red cell precursor enhancers like exogenous erythropoietin (EPO) is one of the alternative techniques to blood transfusion as it stimulates the hemoglobin and reticulocytes production in anaemic patients. In this presentation, Dr. Balestra, shows the first results of increased EPO production after intermittent hyperoxia through breath-hold diving, a process also known as the normobaric oxygen paradox. After the dive, the return back from the increased oxygen partial pressure is considered by the body as a drop of oxygen in the tissues and thus leading to an increase in EPO (similar to a stay at high altitudes). Dr. Balestra was amongst the first scientists to report the possibility to increase EPO with a single non hypoxic stimulus.

Published
2017

27. Variation of Cognitive Function During a Short Stay at Hypobaric Hypoxia Chamber (Altitude: 3842 M).

Author

De Bels, D., Pierrakos, C., Bruneteau, A., Reul, F., Crevecoeur, Q., Marrone, N., Vissenaeken, D., Borgers, G., Balestra, C., Honoré, P. M., and Theunissen, S.

Subjects
CEREBRAL circulation, COGNITIVE ability, HYPOXEMIA, DISSOLVED oxygen in water, TIME perception
Abstract

Objective: To observe the effects of a fast-acute ascent to high altitude on brain cognitive function and transcranial doppler parameters in order to understand the physiological countermeasures of hypoxia. Methods: 17 high-altitude-naïve male subjects (mean age was 26.3 ± 8.1 years) participated in the study. We measured Critical Flicker Fusion Frequency (CFFF), blood oxygen saturation, Psychology Experiment Building (PEBL) including three tests (Modified Math Processing Task, Perceptual Vigilance Task, and Time Estimation Task), as well as Cerebral Blood Flow index (CBFi), mean cerebral artery Systolic and diastolic velocities, Cerebral Pulsatility index (CPi), and heart Rate. All were measured at sea level, at least 1 h after arrival at the hypobaric hypoxia equivalent of 3842 m and 1 h after return to sea level. Results: Under acute exposure to hypobaric hypoxic conditions, significant decrease in CFFF [42.1 ± 1 vs. 43.5 ± 1.7 Hz at sea level (asl), p < 0.01], CBFi (611 ± 51 vs. 665 ± 71 asl, p < 0.01) and blood oxygen saturation (83 ± 4% vs. 98 ± 1% asl, p < 0.001) as compared to pre-ascent values were observed. Physiological countermeasures to hypoxia could be involved as there was no significant change in neuropsychometric tests, Systolic and Diastolic velocities and CPi. A significant increase in Heart Rate (81 ± 15 bpm vs. 66 ± 15 bpm asl, p < 0.001) was observed. All parameters returned to their basal values 1 h after regaining sea level. Conclusion: Hypoxia results in a decrease in CFFF, CBFi and oxygen saturation and in an increase in heart rate. As it decreased, Cerebral Blood Flow index does not seem to be the physiological measurement of choice to hypoxia explaining the maintenance of cognitive performance after acute exposure to hypobaric hypoxia and requires further investigation. Cerebral oxygen delivery and extraction could be one of the underlying mechanisms. [ABSTRACT FROM AUTHOR]

Published
2019
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30. Poster session 2: Thursday 4 December 2014, 08:30-12:30Location: Poster area

Author

Domingos, J, Augustine, D, Leeson, P, Noble, J, Doan, HL, Boubrit, L, Cheikh-Khalifa, R, Laveau, F, Djebbar, M, Pousset, F, Isnard, R, Hammoudi, N, Lisi, M, Cameli, M, Di Tommaso, C, Curci, V, Reccia, R, Maccherini, M, Henein, MY, Mondillo, S, Leitman, M, Vered, Z, Rashid, H, Yalcin, MU, Gurses, KM, Kocyigit, D, Evranos, B, Yorgun, H, Sahiner, L, Kaya, B, Aytemir, K, Ozer, N, Bertella, E, Petulla', M, Baggiano, A, Mushtaq, S, Russo, E, Gripari, P, Innocenti, E, Andreini, D, Tondo, C, Pontone, G, Necas, J, Kovalova, S, Hristova, K, Shiue, I, Bogdanva, V, Teixido Tura, G, Sanchez, V, Rodriguez-Palomares, J, Gutierrez, L, Gonzalez-Alujas, T, Garcia-Dorado, D, Forteza, A, Evangelista, A, Timoteo, AT, Aguiar Rosa, S, Cruz Ferreira, R, Campbell, R, Carrick, D, Mccombe, C, Tzemos, N, Berry, C, Sonecki, P, Noda, M, Setoguchi, M, Ikenouchi, T, Nakamura, T, Yamamoto, Y, Murakami, T, Katou, Y, Usui, M, Ichikawa, K, Isobe, M, Kwon, B, Roh, J, Kim, H, Ihm, S, Barron, AJ, Francis, D, Mayet, J, Wensel, R, Kosiuk, J, Dinov, B, Bollmann, A, Hindricks, G, Breithardt, O, Rio, P, Moura Branco, L, Galrinho, A, Cacela, D, Pinto Teixeira, P, Afonso Nogueira, M, Pereira-Da-Silva, T, Abreu, J, Teresa Timoteo, A, Pavlyukova, E, Tereshenkova, E, Karpov, R, Piatkowski, R, Kochanowski, J, Opolski, G, Barbier, P, Mirea, O, Guglielmo, M, Savioli, G, Cefalu, C, Pudil, R, Horakova, L, Rozloznik, M, Balestra, C, Rimbas, R, Enescu, O, Calin, S, Vinereanu, D, Karsenty, C, Hascoet, S, Hadeed, K, Semet, F, Dulac, Y, Alacoque, X, Leobon, B, Acar, P, Dharma, S, Sukmawan, R, Soesanto, A, Vebiona, K, Firdaus, I, Danny, S, Driessen, MM, Sieswerda, G, Post, M, Snijder, R, Van Dijk, A, Leiner, T, Meijboom, F, Chrysohoou, C, Tsitsinakis, G, Tsiachris, D, Aggelis, A, Herouvim, E, Vogiatzis, I, Pitsavos, C, Koulouris, G, Stefanadis, C, Erdei, T, Edwards, J, Braim, D, Yousef, Z, Fraser, A, Avenatti, E, Magnino, C, Omede', P, Presutti, D, Moretti, C, Iannaccone, A, Ravera, A, Gaita, F, Milan, A, Veglio, F, Scali, M, Simioniuc, A, Fusini, L, Dini, F, Okura, H, Murata, E, Kataoka, T, Mikaelpoor, A, Ojaghi Haghighi, S, Alizadeasl, A, Sharifi-Zarchi, A, Zaroui, A, Ben Halima, M, Mourali, M, Mechmeche, R, Rodriguez Palomares, JF, Maldonado, G, Garcia, G, Otaegui, I, Garcia Del Blanco, B, Teixido, G, Gonzalez Alujas, M, Garcia Dorado, D, Godinho, AR, Correia, A, Rangel, I, Rocha, A, Rodrigues, J, Araujo, V, Almeida, P, Macedo, F, Maciel, M, Rekik, B, Mghaieth, F, Aloui, H, Boudiche, S, Jomaa, M, Ayari, J, Tabebi, N, Farhati, A, Mourali, S, Dekleva, M, Markovic-Nikolic, N, Zivkovic, M, Stankovic, A, Boljevic, D, Korac, N, Beleslin, B, Arandjelovic, A, Ostojic, M, Galli, E, Guirette, Y, Auffret, V, Daudin, M, Fournet, M, Mabo, P, Donal, E, Chin, CW, Luo, E, Hwan, J, White, A, Newby, D, Dweck, M, Carstensen, HG, Larsen, LH, Hassager, C, Kofoed, KF, Jensen, JS, Mogelvang, R, Kowalczyk, M, Debska, M, Kolesnik, A, Dangel, J, Kawalec, W, Migliore, R, Adaniya, M, Barranco, M, Miramont, G, Gonzalez, S, Tamagusuku, H, Davidsen, ES, Kuiper, KK, Matre, K, Gerdts, E, Igual Munoz, B, Maceira Gonzalez, A, Erdociain Perales, M, Estornell Erill, J, Valera Martinez, F, Miro Palau, V, Piquer Gil, M, Sepulveda Sanchez, P, Cervera Zamora, A, Montero Argudo, A, Placido, R, Silva Marques, J, Magalhaes, A, Guimaraes, T, Nobre E Menezes, M, Goncalves, S, Ramalho, A, Robalo Martins, S, Almeida, A, Nunes Diogo, A, Abid, L, Ben Kahla, S, Charfeddine, S, Abid, D, Kammoun, S, Tounsi, A, Hammami, R, Triki, F, Akrout, M, Mallek, S, Hentati, M, Sirbu, CF, Berrebi, A, Huber, A, Folliguet, T, Yang, LT, Shih, J, Liu, Y, Li, Y, Tsai, L, Luo, C, Tsai, W, Babukov, R, Bartosh, F, Bazilev, V, Muraru, D, Cavalli, G, Addetia, K, Miglioranza, M, Veronesi, F, Mihaila, S, Tadic, M, Cucchini, U, Badano, L, Lang, R, Miyazaki, S, Slavich, M, Miyazaki, T, Figini, F, Lativ, A, Chieffo, A, Montrfano, M, Alfieri, O, Colombo, A, Agricola, E, Liu, D, Hu, K, Herrmann, S, Stoerk, S, Kramer, B, Ertl, G, Bijnens, B, Weidemann, F, Brand, M, Butz, T, Tzikas, S, Van Bracht, M, Roeing, J, Wennemann, R, Christ, M, Grett, M, Trappe, HJ, Scherzer, S, Geroldinger, A, Krenn, L, Roth, C, Gangl, C, Maurer, G, Rosenhek, R, Neunteufl, T, Binder, T, Bergler-Klein, J, Martins, E, Pinho, T, Leite, S, Azevedo, O, Belo, A, Campelo, M, Amorim, S, Rocha-Goncalves, F, Goncalves, L, Silva-Cardoso, J, Ahn, H, Kim, K, Jeon, H, Youn, H, Haland, T, Saberniak, J, Leren, I, Edvardsen, T, Haugaa, K, Ziolkowska, L, Boruc, A, Turska-Kmiec, A, Zubrzycka, M, Monivas Palomero, V, Mingo Santos, S, Goirigolzarri Artaza, J, Rodriguez Gonzalez, E, Rivero Arribas, B, Castro Urda, V, Dominguez Rodriguez, F, Mitroi, C, Gracia Lunar, I, Fernadez Lozano, I, Palecek, T, Masek, M, Kuchynka, P, Fikrle, M, Spicka, I, Rysava, R, Linhart, A, Hasselberg, N, Borgquist, R, Platonov, P, Ancona, R, Comenale Pinto, S, Caso, P, Coopola, M, Arenga, F, Rapisarda, O, D'onofrio, A, Sellitto, V, Calabro, R, Rosca, M, Popescu, B, Calin, A, Mateescu, A, Beladan, C, Jalba, M, Rusu, E, Zilisteanu, D, Ginghina, C, Pressman, G, Cepeda-Valery, B, Romero-Corral, A, Moldovan, R, Saenz, A, Orban, M, Samuel, S, Fijalkowski, M, Fijalkowska, M, Gilis-Siek, N, Blaut, K, Galaska, R, Sworczak, K, Gruchala, M, Nowak, R, Ikonomidis, I, Triantafyllidi, H, Trivilou, P, Tzortzis, S, Papadopoulos, C, Pavlidis, G, Paraskevaidis, I, Lekakis, J, Padiyath, A, Li, L, Xiao, Y, Danford, D, Kutty, S, Kaymaz, C, Aktemur, T, Poci, N, Ozturk, S, Akbal, O, Yilmaz, F, Tokgoz Demircan, H, Kirca, N, Tanboga, I, Ozdemir, N, Greiner, S, Jud, A, Aurich, M, Hess, A, Hilbel, T, Hardt, S, Katus, H, D'ascenzi, F, Alvino, F, Focardi, M, Solari, M, Bonifazi, M, Konopka, M, Krol, W, Klusiewicz, A, Burkhard, K, Chwalbinska, J, Pokrywka, A, Dluzniewski, M, Braksator, W, King, GJ, Coen, K, Gannon, S, Fahy, N, Kindler, H, Clarke, J, Iliuta, L, Rac-Albu, M, Cortez-Dias, N, Francisco, A, Silva, G, Kyu, K, Kong, W, Songco, G, Galupo, M, Castro, M, Shin Hnin, W, Ronald Lee, C, Poh, K, Milazzo, V, Di Stefano, C, Tosello, F, Leone, D, Sabia, L, Sobrero, G, Maule, S, Jamiel, AM, Ahmed, AM, Farah, I, Al-Mallah, MH, Petroni, R, Magnano, R, Bencivenga, S, Di Mauro, M, Petroni, S, Altorio, S, Romano, S, Penco, M, Kumor, M, Lipczynska, M, Klisiewicz, A, Wojcik, A, Konka, M, Kozuch, K, Szymanski, P, Hoffman, P, Rimbas, M, Reynaud, A, Lund, L, Persson, H, Hage, C, Oger, E, Linde, C, Daubert, J, Maria Oliveira Lima, M, Costa, H, Gomes Da Silva, M, Noman Alencar, M, Carmo Pereira Nunes, M, Costa Rocha, M, Siala, A, Ozawa, K, Funabashi, N, Takaoka, H, Kobayashi, Y, Matsumura, Y, Wada, M, Hirakawa, D, Yasuoka, Y, Morimoto, N, Takeuchi, H, Kitaoka, H, Sugiura, T, Lakkas, L, Naka, K, Ntounousi, E, Gkirdis, I, Koutlas, V, Bechlioulis, A, Pappas, K, Katsouras, C, Siamopoulos, K, Michalis, L, Evangelou, D, Kalaitzidis, R, Tzeltzes, G, Nakas, G, Generati, G, Bandera, F, Pellegrino, M, Labate, V, Alfonzetti, E, Guazzi, M, Zagatina, A, Zhuravskaya, N, Al-Mallah, M, Alsaileek, A, Qureshi, W, Peyre, M, Amadieu, R, Yamanaka, Y, Sotomi, Y, Iwakura, K, Inoue, K, Toyoshima, Y, Tanaka, K, Oka, T, Tanaka, N, Orihara, Y, Fujii, K, Soulat-Dufour, L, Lang, S, Boyer-Chatenet, L, Van Der Vynckt, C, Ederhy, S, Adavane, S, Haddour, N, Boccara, F, Cohen, A, Huitema, M, Boerman, S, Vorselaars, V, Grutters, J, Gopal, AS, Saha, S, Toole, R, Kiotsekoglou, A, Cao, J, Reichek, N, Meyer, CG, Altiok, E, Al Ateah, G, Lehrke, M, Becker, M, Lotfi, S, Autschbach, R, Marx, N, Hoffmann, R, Frick, M, Nemes, A, Sepp, R, Kalapos, A, Domsik, P, Forster, T, Caro Codon, J, Blazquez Bermejo, Z, Lopez Fernandez, T, Valbuena Lopez, SC, Iniesta Manjavacas, AM, De Torres Alba, F, Dominguez Melcon, F, Pena Conde, L, Moreno Yanguela, M, Lopez-Sendon, JL, Lengyel, C, Orosz, A, Varkonyi, T, Rendon, J, Saldarriaga, CI, Duarte, N, Foldeak, D, Borbenyi, Z, Hamdy, A, Fereig, H, Nabih, M, Abdel-Aziz, A, Ali, A, Broyd, C, Wielandts, JY, De Buck, S, Michielsen, K, Louw, R, Garweg, C, Nuyts, J, Ector, J, Maes, F, Heidbuchel, H, Gillis, K, Bala, G, Tierens, S, Cosyns, B, Maurovich-Horvat, P, Horvath, T, Jermendy, A, Celeng, C, Panajotu, A, Bartykowszki, A, Karolyi, M, Tarnoki, A, Jermendy, G, and Merkely, B

Subjects
medicine.medical_specialty, biology, Early Repolarization Pattern, business.industry, Athletes, Physical therapy, medicine, Radiology, Nuclear Medicine and imaging, General Medicine, Cardiology and Cardiovascular Medicine, business, biology.organism_classification
Published
2014

31. Circulatory bubble dynamics:From physical to biological aspects

Author

Papadopoulou, V, Tang, MX, Balestra, C, Eckersley, RJ, and Karapantsios, TD

Subjects
Decompression sickness, Diving, Education physique, Médecine pathologie humaine, Surfaces and Interfaces, Micronuclei, Sciences biomédicales, Ingénierie biomédicale, Colloid and Surface Chemistry, Degassing, Médecine de l'environnement, Kinésithérapie réadaptation, Physical and Theoretical Chemistry, Gas emboli
Abstract

Bubbles can form in the body during or after decompression from pressure exposures such as those undergone by scuba divers, astronauts, caisson and tunnel workers. Bubble growth and detachment physics then becomes significant in predicting and controlling the probability of these bubbles causing mechanical problems by blocking vessels, displacing tissues, or inducing an inflammatory cascade if they persist for too long in the body before being dissolved. By contrast to decompression induced bubbles whose site of initial formation and exact composition are debated, there are other instances of bubbles in the bloodstream which are well-defined. Gas emboli unwillingly introduced during surgical procedures and ultrasound microbubbles injected for use as contrast or drug delivery agents are therefore also discussed. After presenting the different ways that bubbles can end up in the human bloodstream, the general mathematical formalism related to the physics of bubble growth and detachment from decompression is reviewed. Bubble behavior in the bloodstream is then discussed, including bubble dissolution in blood, bubble rheology and biological interactions for the different cases of bubble and blood composition considered., REVIEW, info:eu-repo/semantics/published

Published
2014
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33. The 'Normobaric Oxygen Paradox'. a new tool for the anaesthetist?

Author

Rocco, M., D Itri, L., David De Bels, Corazza, F., Balestra, C., and Experimental Anatomy

Subjects
Humans, hyperoxia, erythropoietin, anaesthetist, oxygen
Abstract

Hypoxia is the natural trigger for endogenous EPO production but recently the use of intermittent hyperoxia to stimulate EPO has been postulated and this phenomenon has been called the "normobaric oxygen paradox" (NOP). The "NOP" is a mechanism by which oxygen regulates the expression of the Hypoxia Inducible Factor 1 alpha (HIF-1α). The HIF-1α-depending gene regulation is responsible for many different genetic expressions including EPO and VEGF. It has been proposed that relative changes of oxygen availability rather than steady state hypoxic or hyperoxic conditions, play an important role in HIF transcriptional effects. According to this hypothesis, the cell interprets the return to normoxia after a hyperoxic event as an oxygen shortage, and induces HIF-1-regulated gene synthesis, including EPO. Being both a hormone and a cytokine, the actual actions of EPO are complex; its clinical utility has been postulated for neuroprotection and cardioprotection. The precise level of inspired oxygen and the exact timeframe for its iterative administration are not totally known. N-Acetyl-L-Cysteine (NAC) supplementation has been shown to help. All the reported data demonstrate how hyperoxic and hypoxic states can potentially be manipulated if oxygen is been considered as a multifaceted molecule more than just a gas.

Published
2014

34. The use of portable 2D echocardiography and 'frame-based' bubble counting as a tool to evaluate diving decompression stress

Author

Germonpré, P., Papadopoulou, V., Hemelryck, W., Obeid, G., Lafère, P., Robert Eckersley, Tang, M. -X, Balestra, C., Body Composition and Morphology, and Experimental Anatomy

Subjects
musculoskeletal diseases, DEEP STOP, Time Factors, HYPERBARIC DECOMPRESSION, Diving, Point-of-Care Systems, Video Recording, Hygiène et médecine sportives, decompression sickness, WEIGHTED KAPPA, venous gas embolism, Veins, bubbles, diving research, Embolism, Air, Humans, Public, Environmental & Occupational Health, Observer Variation, Science & Technology, Embolism, Air/diagnostic imaging, Doppler, Education physique, Médecine pathologie humaine, Decompression Sickness/classification, risk assessment, Reproducibility of Results, Informatique médicale, Sciences bio-médicales et agricoles, VENOUS GAS-BUBBLES, Sciences biomédicales, DIVERS, Video Recording/statistics & numerical data, Echocardiography, AGREEMENT, PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH, SCI, RELIABILITY, Médecine de l'environnement, arterial gas embolism, Echocardiography/instrumentation, 82 FSW, FORAMEN OVALE, human activities, Life Sciences & Biomedicine, INTRACLASS CORRELATION-COEFFICIENT, Algorithms
Abstract

'Decompression stress' is commonly evaluated by scoring circulating bubble numbers post dive using Doppler or cardiac echography. This information may be used to develop safer decompression algorithms, assuming that the lower the numbers of venous gas emboli (VGE) observed post dive, the lower the statistical risk of decompression sickness (DCS). Current echocardiographic evaluation of VGE, using the Eftedal and Brubakk method, has some disadvantages as it is less well suited for large-scale evaluation of recreational diving profiles. We propose and validate a new 'frame-based' VGE-counting method which offers a continuous scale of measurement., Journal Article, info:eu-repo/semantics/published

Published
2014

37. Supernova remnants and pulsar wind nebulae as seen by the MAGIC Cherenkov Telescope

Author

de Cea Del Pozo, Elsa, Anderhub, Antonelli, H., L. A., Antoranz, Backes, P., Baixeras, M., Balestra, C., Barrio, S., J. A., Bastieri, Becerra, Gonzalez, Becker, J., J. K., Bednarek, Berger, W., Bernardini, K., Biland, E., Bock, A., R. K., Bonnoli, Bordas, G., Borla, Tridon, Bosch, Ramon, Bose, V., Braun, D., Bretz, I., Britzger, T., Camara, D., Carmona, M., Carosi, E., Colin, A., Commichau, P., Contreras, S., J. L., Cortina, Costado, J., M. T., Covino, Dazzi, S., Angelis, De, de Los Reyes, Lotto, De, Maria, De, Sabata, De, Delgado, Mendez, Dominguez, C., Dominis, Prester, Dorner, D., Doro, D., Elsaesser, M., Errando, D., Ferenc, M., Fernandez, D., Firpo, E., Fonseca, R., M. V., Font, Galante, L., Garcia, Lopez, R. J., Garczarczyk, Gaug, M., Godinovic, M., Goebel, N., Hadasch, F., Herrero, D., Hildebrand, A., Hoehne, Moench, Hose, D., Hrupec, J., Hsu, D., C. C., Jogler, Klepser, T., Kranich, S., Barbera, La, Laille, A., Leonardo, A., Lindfors, E., Lombardi, E., Longo, S., Lopez, F., Lorenz, M., Majumdar, E., Maneva, P., Mankuzhiyil, G., Mannheim, N., Maraschi, K., Mariotti, L., Martinez, M., Mazin, M., Meucci1, D., Miranda, M., J. M., Mirzoyan, Miyamoto, R., Moldon, H., Moles, J., Moralejo, M., Nieto, A., Nilsson, D., Ninkovic, K., Orito, J., Oya, R., Paoletti, I., Paredes, R., J. M., Pasanen, Pascoli, M., Pauss, D., Pegna, F., R. G., Perez, Torres, M. A., Persic, Peruzzo, M., Prada, L., PRADA MORONI, PIER GIORGIO, Prandini, E., Puchades, N., Puljak, I., Reichardt, I., Rhode, W., Ribo, M., Rico, J., Rissi, M., Rugamer, S., Saggion, A., Saito, T. Y., Salvati, M., Sanchez, Conde, Satalecka, M., Scalzotto, K., Scapin, V., Schweizer, V., Shayduk, T., Shore, STEVEN NEIL, S. N., Sierpowska, Bartosik, Sillanpaa, A., Sitarek, A., Sobczynska, J., Spanier, D., Spiro, F., Stamerra, S., Stark, A., L. S., Suric, Takalo, T., Tavecchio, L., Temnikov, F., Tescaro, P., Teshima, D., Torres, M., D. F., Turini, Vankov, N., Wagner, H., R. M., Zabalza, Zandanel, V., Zanin, F., Zapatero, R., and Magic, Collaboration

Published
2010

40. Inducing HSP for Protection against DCS: Heat Exposure before Diving Reduces Bubble Formation in Man

Author

Blatteau, Jean-Eric, Gempp, Emmanuel, Pontier, Jm, Balestra, C., Mets, Tony, Germonpre, Peter, Gerontology, and Frailty in Ageing

Subjects
NITRIC-OXIDE, exercise, decompression-sickness, PLASMA-VOLUME, survival, hydration, DIVE, RATS, VASODILATION
Abstract

Heat stress is a nonpharmacological preconditioning strategy which can lead to protection against various types of subsequent insults, such as ischemia, hypoxia, inflammation, drugs, and even bubble-induced injury from decompression. It has been suggested that the protective effect of heat exposure against DCS in rats could be related to biochemical processes involving heat shock proteins (HSP) of the 70-kDa range. The purpose of this study was to determine the efficacy of sauna-induced heat exposure prior to a simulated dive on bubble reduction and to examine the adjustments in Hsp70 concentration and hemodynamic parameters. Sixteen divers were compressed in a hyperbaric chamber to 400 kPa for 25 min and decompressed at a rate of 100 kPa. min(-1) with a 4 min stop at 130 kPa. Each diver performed two dives, one with and one without pre-dive FIR dry sauna session for 30 min at 65 degrees C, ending I hour prior to the dive. Brachial artery flow mediated dilation (FMD), blood pressure, and bodyweight measurements were taken before and after the sauna session along with blood samples for analysis of plasma volume, protein concentrations, plasma osmolality, and plasma Hsp70. Circulating venous bubbles were detected with a precordial Doppler after surfacing. This study shows that a single pre-dive sauna session significantly decreases circulating bubbles after a chamber dive. Plasma Hsp70 significantly increased 2 h after sauna completion. The sauna session led to an extracellular dehydration, resulting in hypovolemia and bodyweight loss. A significant rise in FMD and a reduction in systolic blood pressure and pulse pressure were observed. Inducing HSP from heat stress could offer a new way of reducing decompression sickness risk. Sweat dehydration and NO pathway could be also involved in this protective effect. Further investigation is required to elucidate the preponderant mechanism underlying this heat exposure induced reduction in bubble formation.

Published
2009

41. A box-model approach for a snapshot of Carbon biogeochemical cycle in the northern Adriatic Sea

Author

Catalano G., Balestra C., Bastianini M., Bellucci L., Bernardi Aubry F., Burca M., Cantoni C., Caruso G., Casotti R., Cataletto B., Cozzi S., Del Negro P., Fonda Umani S., Giani M., Giuliani S., Kovacevic V., La Ferla R., Langone L., Luchetta A., Monticelli L., Piacentino S., Pugnetti A., Ramazzo F., Ravaioli M., Socal G., Spagnoli F., and Tirelli V.

Published
2009

50. Do Environmental Conditions Contribute to Narcosis Onset and Symptom Severity?

Author

Lafère, P., Balestra, C., Hemelryck, W., Guerrero, F., and Germonpré, P.

Subjects
*BRAIN, *COGNITION disorders, *DIVING, *NOBLE gases, *LOSS of consciousness, *ENVIRONMENTAL exposure, *SEVERITY of illness index, *DESCRIPTIVE statistics
Abstract

Although many factors contributing to inert gas narcosis onset and severity have been put forward, the available evidence is not particularly strong. Using objective criteria, we have assessed brain impairment associated with narcosis under various environmental diving conditions. 40 volunteers performed a no-decompression dive (33 m for 20 min) either in a dry chamber, a pool or open sea. They were assessed by critical flicker fusion frequency before the dive, upon arriving at depth, 5 min before ascent, on surfacing and 30 min post-dive. Compared to the pre-dive value, the mean value of each measurement was significantly different. An increase of flicker fusion to 105.00 ±0.69% when arriving at depth is followed by a decrease to 94.05 ±0.65%. This impairment persists when surfacing and 30 min post-dive, decreasing further to 96.36±0.73% and 96.24 ±0.73%, respectively. Intragroup comparison failed to demonstrate any statistical difference. When objectively measured narcosis may not be influenced by external factors other than pressure and gas. This might be of importance for training to avoid any over- or underestimation of the severity of narcosis based only on subjective symptoms. [ABSTRACT FROM AUTHOR]

Published
2016
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