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245 results on '"BOHUON, C."'

6. Poster Discussions

Author

López, J., Jiménez, M., Peláez, J., Arce, M. A., Asensio, M. J., Arnalich, F., Hernanz, A., Zweigner, J., Gramm, H. -J., Lamping, N., Kopf, A., Asmus, A., Schumann, R. R., Zimmermann, J., Meinhold, H., Beier, W., Wegscheider, K., Murphy, M., Catania, A., Cutuli, M., Garofalo, L., Valenza, F., Lipton, J. M., Berger, D., Boelke, E., Hiki, N., Lissner, R., Arnold, A., Hausmann, F., Seidelmann, M., Beger, H. G., Berger, D., Braunmueller, H. D., Bōlke, E., Schmidt, U., Ott, S., Seidelmann, H., Bohuon, C., Raymond, J., Assicot, M., Moulin, F., Bergeret, M., Lebon, P., Gendrei, D., Lantéri-Minet, M., Scoazec, J. Y., Dosquet, C., Beyne, P., Voitot, H., Mencia-Huerta, J. M., Lettéron, P., Lebrec, D., Lehmann, C. H., Egerer, K., Georgiew, A., Weber, M., Kox, W. J., Brunkhorst, F. M., Forycki, Z. F., Beier, W., Wagner, J., Orfanos, S. E., Armaganidis, A., Bardouniotou, H., Mavrommati, I., Catravas, J. D., Economidou, J., and Roussos, Ch.

Published
1996
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20. Relationship among neuropeptide Y, catecholamines and haemodynamics in congestive heart failure.

Author

DUBOIS-RANDÉ, J. L., COMOY, E., MERLET, P., BENVENUTI, C., CARVILLE, C., HITTINGER, L., MACQUIN-MAVIER, I., BOHUON, C., and CASTAIGNE, A.

Abstract

The relationship among neuropeptide Y (NPY), catecholamines and haemodynamics was assessed both at baseline and during inotropic intervention in patients with congestive heart failure. Eighteen patients with idiopathic dilated cardiomyopathy (left ventricular ejection fraction (LVEF) = 26± 10%) underwent both right and left catheterization. Haemodynamicparameters were recorded at baseline and during dobutamine infusion. To measure norepinephrine (NE), epinephrine (E) (nmol. l: radioenzymatic assay) and NPY (pmol. l: immunoradiometric assay) plasma concentrations, blood samples were drawn from the femoral artery and from the coronary sinus, both at baseline and during dobutamine infusion. At baseline, NPY concentration were 2·15±0·97pmol.l in the femoral artery and 1 ·97 ±0·63 pmol. l in the coronary sinus. Peripheral concentrations of NPY were, however, no different from those of patients without congestive heart failure: 2·4±2·7pmol. l. Peripheral NE concentration was correlated to haemodynamic parameters: L VEF (r= — 0·65; P<0·01), cardiac index (r = — 0·54; P < 0·05), L Vend-diastolic pressure (r= +0-59; P<005), while peripheral N PY and E concentrations were not. Dobutamine improved haemodynamics, since cardiac index increased by 30% and LV end-diastolic pressure decreased by 40% (P<0·01). Peripheral NE concentration decreased from 6·48 + 4·5 to 482 ±2·69 nmol. l(P<0·05) but there was no change in E (0·99±0·61 vs 1·04 + 0·74 nmol .l) or NPY concentrations (2·41 + 0·99pmol. l). In the coronary sinus, neither NE nor NPY concentrations changed during dobutamine infusion. Thus, low levels of peripheral and coronary sinus NPY concentrations may not render the action of circulating NP Y deleterious to failing hearts. NE but not NP Y is related to haemodynamic parameters. When sympathetic tone decreases, NE and NPY seem to have different patterns of release. However, NPY's local role in neurotransmission in the pathogenesis of congestive heart failure should not be ruled out. [ABSTRACT FROM PUBLISHER]

Published
1992
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22. Radioimmunoassay of colchicine

Author

Bohuon C, Boudène C, and Duprey F

Subjects
Antiserum, biology, Radioimmunoassay, Cell Biology, Biochemistry, chemistry.chemical_compound, Colchicine derivatives, chemistry, Antibody Specificity, biology.protein, Biological fluids, Chromatography, Gel, Colchicine, Animals, Rabbits, Antibody, Bovine serum albumin, Molecular Biology, Haptens, Research Article
Abstract

Antibodies to cholchicine were raised in rabbits after injection of N-desacetylthiocolchicine conjugated to bovine serum albumin. Antisera diluted 1:100 bound 50% of 1.6ng of [3H]colchicine. Cross-reaction of the antisera with colchicine derivatives and other drugs was measured and a radioimmunoassay of colchicine in biological fluids was proposed.

Published
1975

23. Biochemical tests for diagnosis of phaeochromocytoma: urinary versus plasma determinations

Author

J M Alexandre, Comoy E, J M Duclos, Pierre-François Plouin, Joël Ménard, and Bohuon C

Subjects
medicine.medical_specialty, endocrine system, endocrine system diseases, Urinary system, Urology, Adrenal Gland Neoplasms, Pheochromocytoma, Essential hypertension, Catecholamines, Internal medicine, medicine, Humans, In patient, Urinary concentration, False Negative Reactions, General Environmental Science, business.industry, Vanillylmandelate, General Engineering, General Medicine, Metanephrines, medicine.disease, Endocrinology, Intermittent hypertension, Hypertension, General Earth and Planetary Sciences, business, Research Article
Abstract

Fifteen patients with hypertension due to phaeochromocytoma and 35 controls with essential hypertension were studied to assess the diagnostic value of urinary and plasma biochemical determinations in phaeochromocytoma. In every case of phaeochromocytoma the urinary concentration of vanillylmandelate, metanephrines, or adrenaline plus noradrenaline was diagnostic of the disease irrespective of whether the patient was normotensive or hypertensive at the time. Plasma determinations of adrenaline and noradrenaline, however, gave falsely negative results on three occasions. These findings suggest that urinary biochemical determinations--particularly of metanephrines--are more reliable than plasma catecholamine measurements as a test for phaeochromocytoma. The test is particularly useful in patients with intermittent hypertension.

Published
1981

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