1. Clinical impact of forced vital capacity on exercise performance in patients with chronic obstructive pulmonary disease
- Author
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Seong Mi Moon, Kwang Ha Yoo, Yun Soo Hong, Chang Hoon Lee, Do Jin Kim, Hye Yun Park, Kyeong Cheol Shin, Hyun Lee, Ki Suck Jung, Jun Hyeok Lim, Sang Haak Lee, and Chang Youl Lee
- Subjects
Pulmonary and Respiratory Medicine ,Spirometry ,medicine.medical_specialty ,Vital capacity ,macromolecular substances ,Logistic regression ,03 medical and health sciences ,FEV1/FVC ratio ,0302 clinical medicine ,Internal medicine ,medicine ,030212 general & internal medicine ,COPD ,medicine.diagnostic_test ,business.industry ,Odds ratio ,respiratory system ,medicine.disease ,respiratory tract diseases ,nervous system ,030228 respiratory system ,Cohort ,Cardiology ,Original Article ,business ,BODE Index - Score ,circulatory and respiratory physiology - Abstract
Purpose: Reduced Forced vital capacity (FVC) in chronic obstructive pulmonary disease (COPD) is associated with comorbid conditions and behavior restriction. However, limited data are available for the association between reduced FVC and 6-minute walk distance (6MWD) based on COPD severity. Thus, we investigated the relationship between FVC and 6-minute walk distance (6MWD) based on COPD severity. Method: A total of 1,386 COPD patients in the Korean COPD Subgroup Study (KOCOSS) cohort were evaluated. spirometry and six-minute walk test (6MWT) performed at the time of enrollment were analyzed. Patients were divided into two groups, moderate (50%≤ FEV1 %predicted < 80%) (n=895) and severe-to-very severe (FEV1 %prediced < 50%) (n=491). We used a cubic spline model to demonstrate the non-linear relationship between predicted FVC% and 6MWD in moderate and severe-to-very severe COPD patients. Multimodal logistic regression was used to evaluate the association between FVC and short 6MWD. Result: In both moderate and severe-to-very severe COPD patients, those with reduced FVC (< 80% pred) had shorter 6MWD (< 350m in 6MWT, p
- Published
- 2021