Search

Your search keyword '"Ayoub Sabri"' showing total 5 results
Start Over Author "Ayoub Sabri" Language english
5 results on '"Ayoub Sabri"'

1. Prevalence and risk factors for latent tuberculosis infection among healthcare workers in Morocco.

Author

Ayoub Sabri, Jocelyn Quistrebert, Hicham Naji Amrani, Ahmed Abid, Adil Zegmout, Ismail Abderrhamani Ghorfi, Hicham Souhi, Abdelhalim Boucaid, Anas Benali, Rachid Abilkassem, Mohamed Kmari, Amal Hassani, Belyamani Lahcen, Samir Siah, Erwin Schurr, Stéphanie Boisson-Dupuis, Jean-Laurent Casanova, Amine Lahlou, Abdelkader Laatiris, Lhoussain Louzi, Aziz Ouarssani, Ahmed Bourazza, Aziz Aouragh, Bensghir Mustapha, Nezha Messaoudi, Aomar Agader, Aurélie Cobat, Laurent Abel, and Jamila El Baghdadi

Subjects
Medicine, Science
Abstract

Increased prevalence of latent tuberculosis infection (LTBI) has been observed among high-risk populations such as healthcare workers (HCWs). The results may depend on the method of LTBI assessment, interferon-gamma release assay (IGRA) and/or tuberculin skin test (TST). Here, we investigated the prevalence and risk factors for LTBI assessed by both IGRAs and TST in HCWs living in Morocco, a country with intermediate tuberculosis (TB) endemicity and high BCG vaccination coverage. HCWs were recruited in two Moroccan hospitals, Rabat and Meknes. All the participants underwent testing for LTBI by both IGRA (QuantiFERON-TB Gold In-Tube, QFT-GIT) and TST. Different combinations of IGRA and TST results defined the LTBI status. Risk factors associated with LTBI were investigated using a mixed-effect logistic regression model. The prevalence of LTBI among 631 HCWs (age range 18-60 years) varied from 40.7% (95%CI 36.9-44.5%) with QFT-GIT to 52% (95%CI 48.2-56.0%) with TST using a 10 mm cut-off. The highest agreement between QFT-GIT and TST (κ = 0.50; 95%CI 0.43-0.56) was observed with the 10 mm cut-off for a positive TST. For a definition of LTBI status using a double positive result for both QFT-GIT and TST, significant associations were found with the following risk factors: being male (OR = 2.21; 95%CI 1.40-3.49; p = 0.0007), belonging to age groups 35-44 years (OR = 2.43; 95%CI 1.45-4.06; p = 0.0007) and even more 45-60 years (OR = 4.81; 95%CI 2.72-8.52; p = 7.10-8), having a family history of TB (OR = 6.62; 95%CI 2.59-16.94; p = 8.10-5), and working at a pulmonology unit (OR = 3.64; 95%CI 1.44-9.23; p = 0.006). Smoking was associated with LTBI status when defined by a positive QFT-GIT result (OR = 1.89; 95%CI 1.12-3.21; p = 0.02). A high prevalence of LTBI was observed among HCWs in two Moroccan hospitals. Male gender, increased age, family history of TB, and working at a pulmonology unit were consistent risk factors associated with LTBI.

Published
2019
Full Text
View/download PDF

2. The position of Iraqi women within the family, with particular reference to married women

Author

Al-Khayyat, Sana Ayoub Sabri and Sharma, Ursula

Subjects
301, HM Sociology
Abstract

The central theme of this research is an investigation of the extent to which traditional familial attitudes have been instilled in Iraqi women, resulting in deep conflicts amongst those who recognise modern liberalising trends. By allowing Iraqi women to voice their opinions, this study exposes the deep dicotomy within their society. The Western view that Islam is responsible for perpetuating archaic attitudes towards women is also questioned in some depth, together with the idea of the ideology of honour and shame as a means of social control. It will be shown that, because of their socialization (which implicitly incorporates these ideologies and instils feelings of inferiority into the young female) many women carry these ideals into adulthood and marriage. Marital relations, therefore, are examined in some detail. This research shows that many women, particularly working women, suffer a considerable degree of stress. Such problems are perceived at an individual rather than a societal level which inhibits development of any collective consciousness and hinders any improvement of their position within the family. Modern Iraq is still a traditional society in many ways, but enlightened modernisation programmes are bringing about widespread change. Education and work schemes promoted by the Arab Ba'th Socialist Party, are helping to improve the position of women - it is hoped that this research will contribute to this cause.

Published
1985

3. Prevalence and risk factors for latent tuberculosis infection among healthcare workers in Morocco

Author

Aziz Aouragh, Ahmed Bourazza, Ismail Abderrhamani Ghorfi, Aomar Agader, H. Souhi, Anas Benali, Aurélie Cobat, S. Siah, Ayoub Sabri, Stéphanie Boisson-Dupuis, Laurent Abel, Ahmed Abid, Aziz Ouarssani, Amine Lahlou, Hicham Naji Amrani, Belyamani Lahcen, Jamila El Baghdadi, Erwin Schurr, Nezha Messaoudi, Jocelyn Quistrebert, Rachid Abilkassem, Lhoussain Louzi, Bensghir Mustapha, A. Boucaid, A. Zegmout, M. Kmari, Jean-Laurent Casanova, Abdelkader Laatiris, and A. Hassani

Subjects
Bacterial Diseases, Male, Pulmonology, Cross-sectional study, Epidemiology, Logistic regression, Geographical Locations, 0302 clinical medicine, Risk Factors, Medicine and Health Sciences, Prevalence, Public and Occupational Health, 030212 general & internal medicine, Family history, Multidisciplinary, Latent tuberculosis, Incidence (epidemiology), Vaccination, Middle Aged, Vaccination and Immunization, 3. Good health, Morocco, Infectious Diseases, BCG Vaccine, Medicine, Female, Research Article, Adult, medicine.medical_specialty, Tuberculosis, Adolescent, Science, Health Personnel, Immunology, Tuberculin, Models, Biological, 03 medical and health sciences, Diagnostic Medicine, Latent Tuberculosis, Internal medicine, medicine, Humans, Skin Tests, business.industry, Tuberculin Test, Biology and Life Sciences, medicine.disease, bacterial infections and mycoses, Tropical Diseases, Cross-Sectional Studies, 030228 respiratory system, Age Groups, Medical Risk Factors, People and Places, Africa, Population Groupings, Preventive Medicine, business, BCG vaccine, Interferon-gamma Release Tests
Abstract

Increased prevalence of latent tuberculosis infection (LTBI) has been observed among high-risk populations such as healthcare workers (HCWs). The results may depend on the method of LTBI assessment, interferon-gamma release assay (IGRA) and/or tuberculin skin test (TST). Here, we investigated the prevalence and risk factors for LTBI assessed by both IGRAs and TST in HCWs living in Morocco, a country with intermediate tuberculosis (TB) endemicity and high BCG vaccination coverage. HCWs were recruited in two Moroccan hospitals, Rabat and Meknes. All the participants underwent testing for LTBI by both IGRA (QuantiFERON-TB Gold In-Tube, QFT-GIT) and TST. Different combinations of IGRA and TST results defined the LTBI status. Risk factors associated with LTBI were investigated using a mixed-effect logistic regression model. The prevalence of LTBI among 631 HCWs (age range 18-60 years) varied from 40.7% (95%CI 36.9-44.5%) with QFT-GIT to 52% (95%CI 48.2-56.0%) with TST using a 10 mm cut-off. The highest agreement between QFT-GIT and TST (κ = 0.50; 95%CI 0.43-0.56) was observed with the 10 mm cut-off for a positive TST. For a definition of LTBI status using a double positive result for both QFT-GIT and TST, significant associations were found with the following risk factors: being male (OR = 2.21; 95%CI 1.40-3.49; p = 0.0007), belonging to age groups 35-44 years (OR = 2.43; 95%CI 1.45-4.06; p = 0.0007) and even more 45-60 years (OR = 4.81; 95%CI 2.72-8.52; p = 7.10-8), having a family history of TB (OR = 6.62; 95%CI 2.59-16.94; p = 8.10-5), and working at a pulmonology unit (OR = 3.64; 95%CI 1.44-9.23; p = 0.006). Smoking was associated with LTBI status when defined by a positive QFT-GIT result (OR = 1.89; 95%CI 1.12-3.21; p = 0.02). A high prevalence of LTBI was observed among HCWs in two Moroccan hospitals. Male gender, increased age, family history of TB, and working at a pulmonology unit were consistent risk factors associated with LTBI.

Published
2019

4. A genome-wide association study of pulmonary tuberculosis in Morocco

Author

H. Souhi, I. Sentissi, Stéphanie Boisson-Dupuis, Majid Benkirane, Marianna Orlova, S. Zaid, L. Amar, N. El Amraoui, Jean-Laurent Casanova, Aziz Belkadi, Yasser Gharbaoui, Jacinta Bustamante, Erwin Schurr, Laurent Abel, I. Abderrahmani Rhorfi, S. Belkheiri, M. Hakam, Ahmed Abid, Audrey V. Grant, J. El Baghdadi, M. Manessouri, Kebir Alaoui-Tahiri, Anne Boland, Ayoub Sabri, Caroline Deswarte, F. Lazrak, H. Naji Amrani, and A. Bouraqadi

Subjects
0301 basic medicine, Adult, Male, Adolescent, Genotyping Techniques, Population, Genome-wide association study, Single-nucleotide polymorphism, Biology, Polymorphism, Single Nucleotide, Article, Mixed Function Oxygenases, Mycobacterium tuberculosis, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Risk Factors, Genetics, SNP, Humans, Allele, Age of Onset, education, Child, Gene, Tuberculosis, Pulmonary, Genetics (clinical), Alleles, Aged, education.field_of_study, Infant, Reproducibility of Results, Forkhead Transcription Factors, Middle Aged, biology.organism_classification, Human genetics, Introns, 3. Good health, Repressor Proteins, Morocco, 030104 developmental biology, Genetic Loci, 030220 oncology & carcinogenesis, Case-Control Studies, Child, Preschool, Female, Genome-Wide Association Study
Abstract

Although epidemiological evidence suggests a human genetic basis of pulmonary tuberculosis (PTB) susceptibility, the identification of specific genes and alleles influencing PTB risk has proven to be difficult. Previous genome-wide association (GWA) studies have identified only three novel loci with modest effect sizes in sub-Saharan African and Russian populations. We performed a GWA study of 550,352 autosomal SNPs in a family-based discovery Moroccan sample (on the full population and on the subset with PTB diagnosis at

Published
2016

5. Age-dependent association between pulmonary tuberculosis and common TOX variants in the 8q12-13 linkage region

Author

Erwin Schurr, Marianna Orlova, Ayoub Sabri, Vaomalala Raharimanga, Ahmed Abid, Anne Boland, Yasser Gharbaoui, Safa El Azbaoui, Daniel K. Nolan, Luis B. Barreiro, Laurent Abel, Jamila El Baghdadi, Jean-Laurent Casanova, Majid Benkirane, Satoshi Okada, Ismail Abderrahmani Rhorfi, Voahangy Rasolofo, Jacinta Bustamante, Mélanie Migaud, Vincent Richard, Stéphanie Boisson-Dupuis, Audrey V. Grant, Kebir Alaoui-Tahiri, Génétique Humaine des Maladies Infectieuses (Inserm U980), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Imagine - Institut des maladies génétiques (IMAGINE - U1163), Genetics Unit, Military Hospital Mohamed V, Department of Pneumology, Blood Transfusion Center, Institut Pasteur de Madagascar, Réseau International des Instituts Pasteur (RIIP), McGill Centre for the Study of Host Resistance, McGill University = Université McGill [Montréal, Canada], Centre National de Génotypage (CNG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University [New York], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Department of Pediatrics, Faculty of Medicine, Sainte-Justine Hospital Research Centre, Service d'immuno-hématologie pédiatrique [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Infections à Vih, Réservoirs, Pharmacologie des Antirétroviraux et Prévention de la Transmission Mère Enfant, Université Paris Descartes - Paris 5 (UPD5), Pasteur Institute of Paris (Progamme Transversal de Recherche PTR202), Bill and Melinda Gates Foundation, St. Giles Foundation, Jeffrey Modell Foundation and Talecris Biotherapeutics, Rockefeller University Center for Clinical and Translational Science (5UL1RR024143-04) Rockefeller University, and National Institute of Allergy and Infectious Diseases (1R01AI089970-01 and U01AI088685). A.V.G. was partly supported by the Fondation pour la Recherche Médicale and Fondation BNP Paribas. L.B.B. is a scholar of the Fonds de la Recherche en Santé du Québec., Centre de recherche du CHU Sainte-Justine / Research Center of the Sainte-Justine University Hospital [Montreal, Canada], Université de Montréal (UdeM)-CHU Sainte Justine [Montréal]-Université de Montréal (UdeM)-CHU Sainte Justine [Montréal], Génétique Humaine des Maladies Infectieuses ( Inserm U980 ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Paris Descartes - Paris 5 ( UPD5 ), Imagine - Institut des maladies génétiques ( IMAGINE - U1163 ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Paris Descartes - Paris 5 ( UPD5 ), Institut Pasteur de Madagascar-Réseau International des Instituts Pasteur ( RIIP ), The Research Institute of the McGill-University Health Centre, Centre National de Génotypage ( CNG ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, rockefeller university, Université de Montréal-Sainte-Justine Hospital Research Centre, Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Université Paris Descartes - Paris 5 ( UPD5 ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5), Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), McGill University, and Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Necker - Enfants Malades [AP-HP]

Subjects
Male, Linkage disequilibrium, MESH: Mycobacterium tuberculosis, MESH : Tuberculosis, Pulmonary, Genetic Linkage, [SDV]Life Sciences [q-bio], MESH : Genotype, environment and public health, Linkage Disequilibrium, MESH: Genotype, MESH: Madagascar, MESH : Genetic Loci, MESH : Chromosomes, Human, Pair 8, Genetics(clinical), MESH : Female, Genetics (clinical), Genetics, 0303 health sciences, MESH : Linkage Disequilibrium, MESH : High Mobility Group Proteins, integumentary system, MESH: Polymorphism, Single Nucleotide, MESH : Polymorphism, Single Nucleotide, Age Factors, High Mobility Group Proteins, MESH: Genetic Predisposition to Disease, MESH: European Continental Ancestry Group, MESH : Adult, MESH: Case-Control Studies, 3. Good health, Morocco, MESH: Linkage Disequilibrium, Chromosomal region, Female, Chromosomes, Human, Pair 8, Adult, MESH : Case-Control Studies, Tuberculosis, Genotype, MESH : Madagascar, MESH : Male, MESH: Genetic Linkage, macromolecular substances, Biology, Polymorphism, Single Nucleotide, MESH: Genetic Loci, White People, Genetic determinism, Mycobacterium tuberculosis, MESH : European Continental Ancestry Group, 03 medical and health sciences, MESH : Mycobacterium tuberculosis, Report, Madagascar, Genetic predisposition, medicine, Humans, Genetic Predisposition to Disease, Allele, MESH : Morocco, Tuberculosis, Pulmonary, Genotyping, Alleles, 030304 developmental biology, MESH: Age Factors, MESH: Tuberculosis, Pulmonary, MESH: Humans, [ SDV ] Life Sciences [q-bio], 030306 microbiology, MESH: Alleles, MESH : Humans, MESH: Adult, biology.organism_classification, medicine.disease, MESH: High Mobility Group Proteins, MESH : Genetic Linkage, MESH: Male, Genetic Loci, Case-Control Studies, MESH: Morocco, MESH : Genetic Predisposition to Disease, MESH : Age Factors, MESH : Alleles, MESH: Chromosomes, Human, Pair 8, MESH: Female
Abstract

International audience; Only a small fraction of individuals infected with Mycobacterium tuberculosis develop clinical tuberculosis (TB) in their lifetime. Genetic epidemiological evidence suggests a genetic determinism of pulmonary TB (PTB), but the molecular basis of genetic predisposition to PTB remains largely unknown. We used a positional-cloning approach to carry out ultrafine linkage-disequilibrium mapping of a previously identified susceptibility locus in chromosomal region 8q12-13 by genotyping 3,216 SNPs in a family-based Moroccan sample including 286 offspring with PTB. We observed 44 PTB-associated SNPs (p < 0.01), which were genotyped in an independent set of 317 cases and 650 controls from Morocco. A single signal, consisting of two correlated SNPs close to TOX, rs1568952 and rs2726600 (combined p = 1.1 × 10(-5) and 9.2 × 10(-5), respectively), was replicated. Stronger evidence of association was found in individuals who developed PTB before the age of 25 years (combined p for rs1568952 = 4.4 × 10(-8); odds ratio of PTB for AA versus AG/GG = 3.09 [1.99-4.78]). The association with rs2726600 (p = 0.04) was subsequently replicated in PTB-affected subjects under 25 years in a study of 243 nuclear families from Madagascar. Stronger evidence of replication in Madagascar was obtained for additional SNPs in strong linkage disequilibrium with the two initial SNPs (p = 0.003 for rs2726597), further confirming the signal. We thus identified around rs1568952 and rs2726600 a cluster of SNPs strongly associated with early-onset PTB in Morocco and Madagascar. SNP rs2726600 is located in a transcription-factor binding site in the 3' region of TOX, and further functional explorations will focus on CD4 T lymphocytes.

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results