Search

Your search keyword '"Awad, Shady Adnan"' showing total 11 results
Start Over Author "Awad, Shady Adnan" Language english
11 results on '"Awad, Shady Adnan"'

1. Telomere shortening correlates with leukemic stem cell burden at diagnosis of chronic myeloid leukemia

Author

Bouillon, Anne-Sophie, Ventura Ferreira, Monica S., Awad, Shady Adnan, Richter, Johan, Hochhaus, Andreas, Kunzmann, Volker, Dengler, Jolanta, Janssen, Jeroen, Ossenkoppele, Gert, Westerweel, Peter E., te Boekhorst, Peter A.W., Mahon, Francois-Xavier, Hjorth-Hansen, Henrik, Isfort, Susanne, Fioretos, Thoas, Hummel, Sebastian, Schemionek, Mirle, Wilop, Stefan, Koschmieder, Steffen, Saußele, Susanne, Mustjoki, Satu, Beier, Fabian, and Brümmendorf, Tim H.

Published
2018
Full Text
View/download PDF

3. Erythroid/Megakaryocytic Differentiation Confers BCL-XL Dependency and Venetoclax Resistance in Acute Myeloid Leukemia

Author

Dufva, Olli, Kuusanmäki, Heikki, Vaha-Koskela, Markus, Leppä, Aino-Maija, Huuhtanen, Jani, Vänttinen, Ida, Nygren, Petra Johanna, Klievink, Jay, Bouhlal, Jonas, Pölönen, Petri, Zhang, Qi, Awad, Shady Adnan, Mancebo, Cristina, Saad, Joseph, Miettinen, Juho J., Javarappa, Komal Kumar, Aakko, Sofia, Ruokoranta, Tanja, Eldfors, Samuli, Heinäniemi, Merja, Wartiovaara-Kautto, Ulla, Konopleva, Marina, Keränen, Mikko A, Porkka, Kimmo, Wennerberg, Krister, Kontro, Mika, Heckman, Caroline A., and Mustjoki, Satu

Published
2022
Full Text
View/download PDF

4. Epigenetic modifier gene mutations in chronic myeloid leukemia (CML) at diagnosis are associated with risk of relapse upon treatment discontinuation

Author

Awad, Shady Adnan, Brück, Oscar, Shanmuganathan, Naranie, Järvinen, Timo, Lähteenmäki, Hanna, Klievink, Jay, Ibrahim, Hazem, Kytölä, Soili, Koskenvesa, Perttu, Hughes, Timothy P., Branford, Susan, Kankainen, Matti, Mustjoki, Satu, TRIMM - Translational Immunology Research Program, University of Helsinki, Hematologian yksikkö, Digital Precision Cancer Medicine (iCAN), Faculty Common Matters (Faculty of Medicine), HUS Comprehensive Cancer Center, Department of Oncology, Department of Clinical Chemistry and Hematology, STEMM - Stem Cells and Metabolism Research Program, Centre of Excellence in Stem Cell Metabolism, HUSLAB, Clinicum, and HUS Diagnostic Center

Subjects
education, CELLS, 3122 Cancers, 3111 Biomedicine
Abstract

Non

Published
2022

8. Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target.

Author

Dufva, Olli, Kankainen, Matti, Kelkka, Tiina, Sekiguchi, Nodoka, Awad, Shady Adnan, Eldfors, Samuli, Yadav, Bhagwan, Kuusanmäki, Heikki, Malani, Disha, Andersson, Emma I., Pietarinen, Paavo, Saikko, Leena, Kovanen, Panu E., Ojala, Teija, Lee, Dean A., Loughran Jr., Thomas P., Nakazawa, Hideyuki, Suzumiya, Junji, Suzuki, Ritsuro, and Young Hyeh Ko

Abstract

Aggressive natural killer-cell (NK-cell) leukemia (ANKL) is an extremely aggressive malignancy with dismal prognosis and lack of targeted therapies. Here, we elucidate the molecular pathogenesis of ANKL using a combination of genomic and drug sensitivity profiling. We study 14 ANKL patients using whole-exome sequencing (WES) and identify mutations in STAT3 (21%) and RAS-MAPK pathway genes (21%) as well as in DDX3X (29%) and epigenetic modifiers (50%). Additional alterations include JAK-STAT copy gains and tyrosine phosphatase mutations, which we show recurrent also in extranodal NK/T-cell lymphoma, nasal type (NKTCL) through integration of public genomic data. Drug sensitivity profiling further demonstrates the role of the JAK-STAT pathway in the pathogenesis of NK-cell malignancies, identifying NK cells to be highly sensitive to JAK and BCL2 inhibition compared to other hematopoietic cell lineages. Our results provide insight into ANKL genetics and a framework for application of targeted therapies in NK-cell malignancies. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

9. Mutational Landscape of Aggressive Natural Killer Cell Leukemia and Drug Sensitivity Profiling Reveal Therapeutic Options in Natural Killer Cell Malignancies

Author

Dufva, Olli, Kankainen, Matti, Kelkka, Tiina, Awad, Shady Adnan, Sekiguchi, Nodoka, Yadav, Bhagwan, Eldfors, Samuli, Kuusanmäki, Heikki, Andersson, Emma I, Malani, Disha, Pietarinen, Paavo, Saikko, Leena, Kovanen, Panu E, Suzumiya, Junji, Suzuki, Ritsuro, Ko, Young Hyeh, Kim, Won Seog, Chuang, Shih-Sung, Loughran, Thomas P., Jr., Chan, Wing Chung, Ohshima, Koichi, Aittokallio, Tero, Ishida, Fumihiro, and Mustjoki, Satu

Published
2016
Full Text
View/download PDF

11. Crosstalk between tongue carcinoma cells, extracellular vesicles, and immune cells in in vitro and in vivo models.

Author

Al-Samadi A, Awad SA, Tuomainen K, Zhao Y, Salem A, Parikka M, and Salo T

Abstract

The crosstalk between immune cells, cancer cells, and extracellular vesicles (EVs) secreted by cancer cells remains poorly understood. We created three-dimensional (3D) cell culture models using human leiomyoma discs and Myogel to study the effects of immune cells on highly (HSC-3) and less (SCC-25) invasive oral tongue squamous cell carcinoma (OTSCC) cell lines. Additionally, we studied the effects of EVs isolated from these cell lines on the cytotoxicity of CD8 + T and NK cells isolated from three healthy donors. Our analysis included the effects of these EVs on innate immunity in zebrafish larvae. Activated immune cells significantly decreased the proliferation of both OTSCC cell lines and associated with a diminished invasion area of HSC-3 cells. In general, EVs from SCC-25 increased the cytotoxic activity of CD8 + T and NK cells more than those from HSC-3 cells. However, this effect varied depending on the source and the immune and cancer cell subgroups. In zebrafish, the amount of IL-13 mRNA was decreased by SCC-25 EVs. This study describes promising in vitro and in vivo models to investigate interactions between immune cells, cancer cells, and EVs., Competing Interests: CONFLICTS OF INTEREST The authors declare that they have no conflicts of interest.

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results