1. Monte Carlo simulation of scattered circularly polarized light in biological tissues for detection technique of abnormal tissues using spin-polarized light emitting diodes
- Author
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Nozomi Nishizawa, Takahiro Kuchimaru, Kazumasa Takahashi, Hiro Munekata, and Atsushi Hamada
- Subjects
010302 applied physics ,Physics ,Physics and Astronomy (miscellaneous) ,business.industry ,Quantitative Biology::Tissues and Organs ,Physics::Medical Physics ,Monte Carlo method ,General Engineering ,FOS: Physical sciences ,General Physics and Astronomy ,Scattering process ,Sampling depth ,01 natural sciences ,Tumor tissue ,Quantitative Biology::Cell Behavior ,Optics ,Biological Physics (physics.bio-ph) ,0103 physical sciences ,Physics - Biological Physics ,business ,Spin (physics) ,Circular polarization ,Optics (physics.optics) ,Physics - Optics ,Diode - Abstract
The circular polarization of light scattered by biological tissues provides valuable information and has been considered as a powerful tool for the diagnosis of tumor tissue. We propose a non-staining, non-invasive and in-vivo cancer diagnosis technique using an endoscope equipped with circularly polarized light-emitting diodes (spin-LEDs). We studied the scattering process of the circularly polarized light against cell nuclei in pseudo-healthy and cancerous tissues using the existing Monte Carlo method. The calculation results indicate that the resultant circular polarizations of light scattered in pseudo tissues shows clear difference in a wide range of detection angle, and the sampling depth depends on those detection angles. The structure of the endoscope probe comprising spin-LEDs is designed based on the calculation results, providing structural and depth information regarding biological tissues simultaneously., 17pages, 3 figures
- Published
- 2020