1,965 results on '"Asma"'
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2. A Case of Dedifferentiated Liposarcoma That Contributes to Accompanying Vessels of Various Size.
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Yamada, Yosuke, Mizoguchi, Kai, Shiba, Eisuke, Mishima, Honami, Otsuki, Shinya, Hoki, Masahito, Hirata, Masahiro, Sakamoto, Akio, Matsuda, Shuichi, Marx, Alexander, Hisaoka, Masanori, and Haga, Hironori
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SOFT tissue tumors , *STRIATED muscle , *SMOOTH muscle , *MUSCLE cells , *IN situ hybridization - Abstract
Dedifferentiated liposarcoma (DDLPS) is a non-lipogenic sarcoma, generally arising from well-differentiated liposarcoma (WDLPS), although it can develop de novo. DDLPS tumors rarely trans-differentiate into non-adipose mesenchymal tissues; however, the latter lack notable variety and mostly show striated muscle or osteogenic/chondrogenic differentiation. Here, we report a case of DDLPS that contained numerous atypical vessels. A man in his sixties presented with a large tumor in his right thigh, and the tumor was surgically resected. Microscopically, most of the tumor was WDLPS, but a minor portion showed DDLPS, consisting of high-grade spindle cells. Remarkably, the DDLPS contained vessels of various sizes with atypical cytoarchitecture, including vessels with seemingly muscular layers. Immunohistochemically, the atypical cells within the vascular wall expressed aSMA, consistent with smooth muscle cells or pericytes, whereas surrounding high-grade spindle cells only focally expressed it, and these aSMA-positive cells within the vessels exhibited MDM2 amplification by immuno-fluorescence in situ hybridization. Our results demonstrate that DDLPS can trans-differentiate into smooth muscle cells of various-sized accompanying vessels, which may support their survival and proliferation. [ABSTRACT FROM AUTHOR]
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- 2024
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3. NEAR-FATAL ASTHMA: CASE REPORT IN THE EMERGENCY DEPARTMENT OF HOSPITAL SANTA ROSA.
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Rojas Pérez, William and Delgado Del Aguila, Jorge L.
- Abstract
Copyright of Revista de la Facultad de Medicina Humana is the property of Instituto de Investigaciones en Ciencias Biomedicas de la Universidad Ricardo Palma and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2024
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4. Asma y embarazo: fisiopatología, diagnóstico y manejo farmacológico
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Paulina Barría
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Asma ,Embarazo ,Manejo ,Medicine - Abstract
Resumen: El asma bronquial una de las patologías crónicas más frecuentes en el embarazo, afectando entre el 6 al 10% de la población de mujeres en gestación según reportes internacionales. De este grupo de pacientes, aproximadamente un tercio presentará un deterioro importante de los síntomas, exponiendo a la madre y el feto a un alto riesgo de exacerbaciones y uso de corticoides sistémicos. El mal control de los síntomas del asma se debe en muchos casos a dosis subóptimas, e incluso suspensión de la terapia con corticosteroide inhalado, que constituye la base de la terapia antiinflamatoria y controladora en el asma. Está demostrado que el asma mal controlada en el embarazo aumenta el riesgo de complicaciones obstétricas. El manejo respiratorio de estas pacientes debe ser proactivo, basado en la educación y el uso informado de los tratamientos antiasmáticos, altamente efectivos y de fácil acceso para la mayoría de las pacientes. En este artículo se revisará la fisiopatología, el diagnóstico y manejo farmacológico del asma en el embarazo. Abstract: Bronchial asthma is considered one of the most common chronic pathologies in pregnancy, affecting between 6 to 10% of pregnant women according to international reports. In this group of patients, approximately one third will present a significant aggravation in asthma symptoms, exposing the mother and fetus to a high risk of exacerbations and use of systemic corticosteroids. Poor control of asthma symptoms is in many cases due to suspension or suboptimal therapy with inhaled corticosteroid, which constitutes the basis of anti-inflammatory and controller therapy in asthma. It has been shown that poorly controlled asthma during pregnancy increases the risk of obstetric complications. The respiratory management of these patients must be proactive, patient education based and with informed use of anti-asthmatic treatments, which are highly effective and, for most patients, easily accessible. This article will review the pathophysiology, diagnosis and pharmacological management of asthma in pregnancy.
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- 2024
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5. Relación entre la calidad del aire y el asma en habitantes de grandes altitudes, La Paz, Bolivia (3.600 m.s.n.m.)
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Lizeth Huanca-Laura, Marilyn Aparicio, Demetrio Jemio, Mariana Hurtado, Mayra Huanca, and Alexis Chuquimia
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criterios de calidad del aire ,material particulado ,asma ,espirometría ,Medicine ,Arctic medicine. Tropical medicine ,RC955-962 - Abstract
Introducción. El asma es una enfermedad crónica que afecta a millones de personas en todo el mundo. La calidad del aire es uno de los factores clave que puede desencadenar los síntomas del asma. Objetivo. Analizar la calidad del aire y su relación con el asma en habitantes de grandes altitudes en La Paz (Bolivia). Materiales y métodos. Se desarrolló un estudio analítico, descriptivo y retrospectivo. Se recolectaron datos de pacientes con diagnóstico de asma en el Instituto Nacional del Tórax y en el Instituto Boliviano de Biología de Altura. Además, se monitoreó la calidad del aire y su material particulado en las estaciones de la “Red de monitoreo de la calidad del aire”. Resultados. El 56,9 % de los casos fueron mujeres del Instituto Nacional del Tórax y el 45,7 % del Instituto Boliviano de Biología de Altura. En ambas instituciones, la media de edad fue de 47 años y los pacientes presentaban sobrepeso u obesidad. Se registraron incrementos de material particulado fino (PM2,5) en otoño, invierno y primavera, en 2014, 2016-2019 y en las cuatro estaciones del 2015. El material particulado inhalable grueso (PM10) se incrementó en otoño e invierno del 2014 al 2020, dentro de los límites establecidos. Se observó una asociación positiva y significativa entre la concentración de material particulado PM2,5 y los parámetros espirométricos de capacidad vital forzada, flujo espiratorio máximo y el porcentaje de reversión. La relación de partículas PM10 y los parámetros espirométricos de capacidad vital forzada, volumen espiratorio máximo en el primer segundo y flujo espiratorio máximo, también fue estadísticamente significativa. Conclusión. Los casos de asma se presentaron en promedio a los 47 años y en personas con sobrepeso u obesidad. Se observó una asociación positiva entre el material particulado, PM2,5 y PM10, con los parámetros espirométricos, la cual fue más marcada con las partículas PM2,5.
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- 2024
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6. Birth weight and asthma in young adults of a Brazilian birth cohort.
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Vitti, Fernanda Pino, Padilha, Luana Lopes, Grandi, Carlos, Bettiol, Heloisa, Barbieri, Marco Antonio, Vianna, Elcio Oliveira, Ribeiro, Cecília Claudia Costa, and Cardoso, Viviane Cunha
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BIRTH weight ,LOW birth weight ,COHORT analysis ,RESPIRATORY infections ,ASTHMA ,BODY mass index ,LUNGS ,STRUCTURAL equation modeling ,WHEEZE - Abstract
Copyright of Revista Ciência & Saúde Coletiva is the property of Associacao Brasileira de Pos-Graduacao em Saude Coletiva and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2024
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7. Epidemiological profile of allergic respiratory disease in Mexican children.
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Nora González-Díaz, Sandra, Macías-Weinmann, Alejandra, Elizabeth De Lira-Quezada, Cindy, Gonzalez-Gonzalez, Valeria, Hernández-Sánchez, Hilda, Ivett Guzán-Avilán, Rosa, Noyola-Pérez, Andrés, and Macouzet-Sánchez, Carlos
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RESPIRATORY diseases , *ALLERGIES , *DISEASE prevalence , *EPIDEMIOLOGY , *MEDICAL care - Abstract
Objective: Report the prevalence and severity of the most common allergic diseases in children living in Monterrey, México. Methods: Cross-sectional multi-center survey on the most common allergic diseases, completed by parents of 6-7-year-old children and by 13-14- year-old adolescents in the Monterrey metropolitan area, between January 2018 and December 2019. Results: A total of 3,044 questionnaires were eligible for the analysis. Among children between 6-7 years old, 30.2% (n = 143/473) presented wheezing at any time in their life; with a higher prevalence in the male population. In the adolescent group, 26.4% reported having experienced wheezing at some point in their life, with a slight predominance in the female group (54.9%). Conclusions: Knowing the prevalence of allergic diseases in our population gives us tools to generate strategies that allow us to provide the best quality healthcare to our patients. [ABSTRACT FROM AUTHOR]
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- 2024
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8. Inmunoterapia sublingual con extractos alergénicos de ácaros Valergen en niños con Asma Bronquial sensibilizados (Original).
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Estévez González, Jaciel, Ramírez García, Jorge Luis, and Arias Gómez, Licet
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SUBLINGUAL immunotherapy ,ALLERGENIC extracts ,BRONCHIAL diseases ,ALLERGIC rhinitis ,SOCIODEMOGRAPHIC factors ,ALLERGENS ,DERMATOPHAGOIDES ,ASTHMA - Abstract
Copyright of Roca: Revista Científico-Educacional de la Provincia de Granma is the property of Universidad de Granma, Departamento Editorial and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2024
9. Atopic march in a primary care clinic.
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Manzanares Santos, Silvia, Tainta León, Lucía, and Bercedo Sanz, Alberto
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CROSS-sectional method ,PEARSON correlation (Statistics) ,ATOPIC dermatitis ,PRIMARY health care ,ALLERGIES ,SYMPTOMS ,DESCRIPTIVE statistics ,CHI-squared test ,FOOD allergy ,PEDIATRICS ,ALLERGIC rhinitis ,SEASONAL variations of diseases ,RESEARCH methodology ,MEDICAL records ,ACQUISITION of data ,ANTIGEN-antibody reactions ,DATA analysis software ,ASTHMA - Abstract
Copyright of Revista Pediatría de Atención Primaria is the property of LUA Ediciones 3.0 S.L. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2024
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10. Role of deep convection and dynamics on the tracer distribution in the upper troposphere and lower stratosphere region during active and break phases of the Asian summer monsoon.
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Satheesh Chandran, P. R. and Sunilkumar, S. V.
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STRATOSPHERE , *TROPOSPHERE , *MONSOONS , *WATER vapor , *BRIGHTNESS temperature - Abstract
The Asian Summer Monsoon (ASM) exhibit different modes of variability in which the active and break phases is one of the most prominent intraseasonal scale variability of the ASM. The shift in convective centres to more polluted regions coupled with the associated circulation features during these phases results in a redistribution of trace species in the upper troposphere and lower stratosphere (UTLS) region. Apropos to this, this study presents a quantitative assessment of the variability in the spatial distribution of ozone, carbon monoxide (CO) and water vapour (H2O) in the UTLS during the active and break phase of ASM with respect to the seasonal mean background using fifteen years (2005–2019) of Aura-MLS observations in conjunction with reanalysis data sets, cloud-top brightness temperatures and trajectory analysis. These 15-years of data is used to make composite maps of tracer anomalies to investigate the varying influence of monsoon convection, transport and ASMA dynamics in the UTLS region during the active/break phase. This study shows that, while the distribution of trace species during both phases is determined by the combined role of convection and transport in the upper troposphere, changes in ASMA modes, transport and tropopause dynamics during the active/break phases controls the spatial pattern of both tropospheric and stratospheric species near the tropopause level. [ABSTRACT FROM AUTHOR]
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- 2024
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11. Reconsultas tempranas al servicio de urgencias antes y después de un protocolo para la crisis asmática del adulto: estudio de cohorte retrospectivo
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Vanesa Romina Ruiz, Diego Hernán Giunta, Sergio Daniel Zunino, Yulian Marcos Battellini, Bernardo Julio Martinez, Marlene Padilla Lopez, and María Florencia Grande-Ratti
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asma ,servicio de urgencia en hospital ,personal de salud ,inhaladores de dosis medida ,estado asmático ,urgencias médicas ,Medicine - Abstract
Objetivo: Comparar las reconsultas al servicio de urgencias (SU) por asma durante la semana posterior al alta y explorar los factores asociados antes y después de la implementación de un protocolo asistencial. Materiales y métodos: Se realizó un estudio de cohorte retrospectivo que incluyó las consultas por crisis asmática de adultos al SU de un hospital universitario en los períodos 2016-2018 (preprotocolo) y 2019-2020 (posprotocolo). Se utilizó un modelo de regresión logística multivariado y se reportaron odds ratios (OR) e intervalos de confianza al 95 % (IC95%). Se consideró significativo un valor p < 0,05. Resultados: Las reconsultas fueron 38 (31,40 %) para el período preprotocolo y 33 (26,61 %) para el período posprotocolo. En el modelo de regresión multivariable, no se encontraron diferencias en las reconsultas tempranas al comparar el período posprotocolo con el período preprotocolo (OR 0,68; IC95% 0,26-1,74; p=0,421). Los factores asociados a las reconsultas tempranas fueron la edad (OR: 1,02; IC95%:1,00-1,04; p=0,017), el sexo masculino (OR 0,21 IC95%: 0,08-0,59; p=0,003), y el haber tenido más de una consulta al SU en el último año (OR 6,19 IC95%: 2,48-15,46; p
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- 2024
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12. PRO-ASMA: valutazione dei patientreported outcomes nei pazienti con asma grave.
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Tagariello, Federico
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Patients with severe asthma often do not respond to inhalation therapy and have inadequate symptoms control that negatively affects their social and professional life. The development of new “biological” drugs has revolutionized the treatment of this subgroup of patients, providing better symptom control, reducing the number of exacerbations and allowing for greater disease control. However, improvement in clinical/functional parameters does not necessarily translate into an improvement in quality of life. This study aims to assess the impact of biological drugs on patient quality of life and patient reported outcomes by evaluating changes in the Asthma Quality of Life Questionnaire and SF-36 scores. [ABSTRACT FROM AUTHOR]
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- 2024
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13. Cumplimiento del tratamiento farmacológico en enfermedades crónicas no transmisibles en la población colombiana: revisión sistemática y metaanálisis
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Catalina Cáceres, Álvaro José Lora, Silvia Juliana Villabona, María Catalina Rocha, and Paul Anthony Camacho
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enfermedad crónica ,enfermedades no transmisibles ,cumplimiento del tratamiento ,hipertensión ,diabetes mellitus ,enfermedad pulmonar obstructiva crónica ,dislipidemias ,accidente cerebrovascular ,asma ,Medicine ,Arctic medicine. Tropical medicine ,RC955-962 - Abstract
Introducción. Las enfermedades crónicas no transmisibles representan la principal causa de muerte en el mundo y su prevalencia va en aumento debido a la transición epidemiológica. A pesar de los avances en su manejo, las cifras de control son deficientes y esto se atribuye a múltiples factores, como el cumplimiento del tratamiento farmacológico, que es uno de los más representativos y menos estudiados en la población colombiana. Objetivo. Establecer la frecuencia de casos que cumplieron con el tratamiento farmacológico en pacientes colombianos con hipertensión arterial, enfermedad cerebrovascular, diabetes mellitus, asma, enfermedad pulmonar obstructiva crónica y dislipidemia, entre el 2005 y el 2022. Materiales y métodos. Se llevó a cabo una revisión sistemática de la literatura y un metaanálisis de los estudios identificados mediante las bases de datos Medline y LILACS para sintetizar cuantitativamente el porcentaje de cumplimiento del tratamiento. Resultados. Catorce estudios cumplieron los criterios de inclusión y se analizaron 5.658 pacientes. El cumplimiento del tratamiento fue del 59 %, con una heterogeneidad alta entre los estudios incluidos (IC95 % = 46-71 %; I2 = 98,8 %, p
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- 2023
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14. Investigation of the Phenological and Climate Indices of Some Table and Wine Grapes and Their Growing Status in the Samsun-Bafra Plain (Türkiye).
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KARABEKTAŞOĞLU, Şinasi, KÖSE, Bülent, and SVYANTEK, Andrej
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GRAPE yields ,CLIMATE change ,HIGH temperature (Weather) ,VITICULTURE ,HUMIDITY - Abstract
Copyright of Anadolu Tarım Bilimleri Dergisi is the property of Ondokuz Mayis Universitesi, Ziraat Fakultesi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2024
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15. Genetic Potential of Grapevine in Türkiye.
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İŞÇİ, Burçak and ALTINDİŞLİ, Ahmet
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GRAPE genetics ,VITICULTURE ,GRAPE varieties ,BIOMARKERS ,GERMPLASM - Abstract
Copyright of Anadolu (1300-0225) is the property of Anadolu Dergisi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2024
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16. Economic burden assessment for the management of asthma patients at Mexico's National Institute for Respiratory Diseases.
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Cano-Salas, María del Carmen, Luis Miguel-Reyes, José, Sánchez-Trejo, Karen, del Carmen López-Estrada, Erika, Salas-Hernández, Jorge, Arroyo-Rojas, Monserrat Evelia, Castañeda-Valdivia, Mauricio, Escobar-Preciado, Monserrat, Guzmán-Vázquez, Silvia, Ricardo García-García, Sergio, and Soto-Molina, Herman
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MEDICAL research , *ASTHMA treatment , *ASTHMATICS , *RESPIRATORY diseases - Abstract
Objective: Determine the annual economic burden of the disease from an institutional perspective and based on GINA's recommended classification in a retrospective cohort of adults treated at Instituto Nacional de Enfermedades Respiratorias (INER) of Mexico City. Methods: A retrospective, longitudinal observational study comprised by data from 247 female asthma patients, annual direct costs were estimated including: visits, laboratory tests, pharmacological treatment and management of crisis or exacerbations, to determine the annual burden of the disease from an institutional perspective and according to Global Initiative for Asthma classification. Results: The average annual cost was $43,813.92, which increased in relation to the need of inhaled corticosteroids and long-acting beta agonists dosage increase. The average doctor's appointment cost was $2,004.57, $982.82 for crisis management and $2,645.95 for laboratory testing. Pharmacological treatment represented the main economic burden with an annual average cost of $38,180.58. Conclusions: The results highlight an economic burden of asthma estimated at an annual cost per patient of $43,813.92 MXN (SD=93,348.85) in the context of the third level of care in the Mexican public health system. The asthma severity and treatments such as biologics were the main factors that increased direct costs of care. [ABSTRACT FROM AUTHOR]
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- 2024
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17. Telehealth for children and adolescents with chronic pulmonary disease: systematic review.
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Barros Faiçal, Adriana Virgínia, Ribeiro Mota, Laís, Afonseca Correia, Danilo d’, Prazeres Monteiro, Larissa, Lúcia de Souza, Edna, and Terse-Ramos, Regina
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LUNG diseases , *EMERGENCY room visits , *WEBSITES , *MOBILE games , *TELEMEDICINE - Abstract
Objective: To revise the impact of telehealth on the quality of life, reduction in pulmonary exacerbations, number of days using antibiotics, adherence to treatment, pulmonary function, emergency visits, hospitalizations, and the nutritional status of individuals with asthma and cystic fibrosis. Data source: Four databases were used, MEDLINE, LILACS, Web of Science and Cochrane, as well as manual searches in English, Portuguese and Spanish. Randomized clinical trials, published between January 2010 and December 2020, with participants aged 0 to 20 years, were included. Data synthesis: Seventy-one records were identified after the removal of duplicates; however, twelve trials were eligible for synthesis. Included trials utilized: mobile phone applications (n=5), web platforms (n= 4), mobile telemedicine unit (n=1), software with an electronic record (n=1), remote spirometer (n=1), and active video games platform (n=1). Three trials used two tools, including telephone calls. Among the different types of interventions, improvement in adherence, quality of life, and physiologic variables were observed for mobile application interventions and game platforms compared to usual care. Visits to the emergency department, unscheduled medical appointments, and hospitalizations were not reduced. There was considerable heterogeneity among studies. Conclusions: The findings suggest that better control of symptoms, quality of life, and adherence to treatment can be attributed to the technological interventions used. Nevertheless, further research is needed to compare telehealth with face-to-face care and to indicate the most effective tools in the routine care of children with chronic lung diseases. [ABSTRACT FROM AUTHOR]
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- 2024
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18. Determination of the Relationship Between the Number of Clusters and Primary Bud Size in Vitis vinifera and Vitis labrusca Grapevines by Histological Sectioning Method.
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KÜPE, Muhammed
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GRAPES ,PLANT histology ,VITIS vinifera ,FOX grape ,HISTOLOGY - Abstract
Copyright of Erzincan University Journal of Science & Technology is the property of Erzincan Binali Yildirim Universitesi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2024
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19. Relación entre toxocariosis y asma: estudio prospectivo en niños del Hospital Nacional Cayetano Heredia, Lima, Perú
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Laurent Gétaz Schaller, Frine Samalvides Cuba, Judith Breña Chavez, David Torrejon, and Ciro Maguiña Vargas
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Seroprevalencia ,Asma ,Toxocara canis ,Factor de riesgo ,Medicine - Abstract
Introducción: la parasitosis zoonótica causada por Toxocara canis ha sido sugerida como posible agente etiológico del asma. Objetivo: evaluar la asociación entre la infección por Toxocara canis y el asma en niños del Hospital Nacional Cayetano Heredia (HNCH), Lima, Perú. Asimismo evaluar los factores asociados a la infección por T. canis en la población de estudio. Material y métodos: estudio caso-control, que incluyó a 75 niños asmáticos y 75 niños no asmáticos, de 2 a 13 años, atendidos en el HNCH en el año 2002. Se aplicó un cuestionario para evaluar los factores asociados a toxocariosis y a asma respectivamente. La seroprevalencia de T. canis fue determinada mediante la prueba ELISA IgG para T. canis. Resultados: la seroprevalencia de toxocariosis fue de 16%, no se encontró una asociación significativa entre la seropositividad para Toxocara canis y el asma. Sin embargo se observó una relación estadísticamente significativa entre una mayor frecuencia de crisis de sibilancia nocturna y una serología positiva para Toxocara canis. Los factores asociados a la toxocariosis fueron el contacto intenso con perros, particularmente con cachorros y una ausencia de grado de instrucción universitario de los padres. Los factores asociados al asma fueron: el poco contacto con perros y el grado de instrucción universitario de los padres. Conclusiones: no hubo asociación entre la presencia de serología positiva para T. canis y asma, pero sí con una mayor frecuencia de sibilancia nocturna. Son necesarios estudios posteriores que evalúen esta última observación.
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- 2024
20. Uma abordagem MCDA para identificar lacunas e perspectivas sobre o tratamento de asma no Brasil
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Frederico Silva Valentim Sallum, Wender Aparecido Oliveira, Márcio Ferreira Penha, and Fabiana Gatti de Menezes
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Asma ,CONITEC ,relatórios de recomendação ,classificação de critérios ,MCDA ,Pharmacy and materia medica ,RS1-441 ,Pharmaceutical industry ,HD9665-9675 - Abstract
Introdução: A asma é uma doença respiratória crônica que tem chamado a atenção pelo número de casos no Brasil e no mundo. Diferentes tecnologias para asma têm sido submetidos a Comissão Nacional de Incorporação de Tecnologias (Conitec) para incorporação no Sistema Único de Saúde do Brasil. Objetivo: Este artigo tem como objetivo analisar os relatórios de recomendação sobre tecnologias para tratamento de asma disponibilizados pela Conitec no período de fevereiro de 2012 a maio de 2021 para classificar os principais critérios de análise como ponto forte ou fraco para cada tecnologia. Métodos: Uma busca por relatórios de recomendação sobre tecnologias para tratamento de asma submetidos para incorporação no período descrito acima foi performada na base de dados da Conitec. A partir disso, uma estrutura de análise de decisão multicritério (MCDA) foi estabelecida para classificar cada critérios como ponto forte ou fraco. Resultados: Foram encontrados nove relatórios de recomendação sobre asma representando a submissão de dez tecnologias, formando um conjunto de alternativas: omalizumabe (três submissões: 2013; 2016; 2019), fluticasona (duas submissões: 2013; 2015); budesonida+formoterol (duas submissões: 2015; 2021), tiotrópio, ben- ralizumabe, mepolizumabe (2021). Além disso, o seguinte conjunto de critérios foi estabelecido: eficácia; segurança; avaliação econômica; e impacto orçamentário. Tiotrópio e benralizumabe obtiveram todos os critérios classificados como ponto forte. Fluticasona (2013) obteve todos os critérios classificados como ponto fraco. Conclusão: Foi possível classificar os quatro critérios como ponto forte ou fraco para cada tecnologia submetida à Conitec. A análise proposta pode ser facilmente aprimorada para apoiar o processo de tomada de decisão a partir de diferentes características.
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- 2024
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21. Identificación y sensibilización a hongos ambientales en Lima, Perú
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Oscar Manuel Calderón LLosa
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Aerobiología ,esporas ,rinitis ,asma ,prick test a hongos ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Objetivo: Identificar y registrar las esporas de hongos más importantes captadas en nuestra estación de aerobiología, además reportar la prevalencia de sensibilización cutánea a estos alérgenos. Métodos: La identificación y los conteos de esporas de hongos se realizaron según la técnica estandarizada con un equipo colector Burkard Spore Trap For Seven Days, siguiendo las recomendaciones de la National Allergy Bureau (NAB), de la American Academy Allergy Asthma and Immunology (AAAAI). El equipo se instaló a 20 m de altura desde el nivel del suelo, en la azotea de la Clínica SANNA El Golf, distrito de San Isidro, (12°5'54"S 77°3'6"O), en la zona sur-oeste del área urbana de Lima. El periodo de captación se llevó a cabo entre septiembre de 2020 y octubre de 2021. Se realizaron estudios de pruebas cutáneas (skin prick-test), según recomendaciones de la Sociedad Española de Alergología e Inmunología Clínica (SEAIC), en 200 pacientes (entre 18 y 60 años), con sintomatología de rinoconjuntivitis y/o asma. Fueron evaluados en el servicio de Alergología de la Clínica SANNA El Golf. Se aplicaron extractos alergénicos de ácaros del polvo (Dermatophagoides pteronyssinus, Dermatophagoides farinae, Blomia tropicalis), epitelios de gato y perro, Periplaneta americana, mezclas de seis gramíneas, mezclas de malezas, hongos ambientales (Cladosporium herbarum, Alternaria alternata, Aspergillus fumigatus, Penicillium notatum, Nigrospora spp.), extractos del laboratorio INMUNOTEK-España. Además, testeamos otros alérgenos fúngicos de Fusarium spp, Stemphylium spp, Curvularia spp, una mezcla de Helmintosporum/Dreschlera spp. del laboratorio DIATER-Argentina. Resultados: Identificamos esporas de Alternaria alternata, Cladosporium spp., Nigrospora spp., Stemphylium spp., Fusarium spp., Curvularia spp., Dreschlera/Helmintosporum spp. Los pacientes mostraron sensibilización a Cladosporium herbarum (14%), Fusarium spp. (13,5%), Nigrospora spp. (8%), Alternaria Alternata (7%), Stemphylium (6%), Dreschlera/Helmintosporium spp. (5,5%), Curvularia spp. (3%) y Aspergillus fumigatus (2,5%). Conclusiones: Los habitantes de la zona sur-oeste de la ciudad urbana de Lima están expuestos a distintas esporas de hongos con potencial alergénico, identificándose mayor concentración durante los meses de verano y otoño. Se demuestra sensibilización cutánea en porcentajes variables a las esporas fúngicas identificadas en este muestreo aerobiológico. Los resultados de este estudio deberían ampliarse y ser comparados con data en los años siguientes, identificar fluctuaciones estacionales y anuales y extender los captadores a otras locaciones en Lima.
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- 2024
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22. A Case of Dedifferentiated Liposarcoma That Contributes to Accompanying Vessels of Various Size
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Yosuke Yamada, Kai Mizoguchi, Eisuke Shiba, Honami Mishima, Shinya Otsuki, Masahito Hoki, Masahiro Hirata, Akio Sakamoto, Shuichi Matsuda, Alexander Marx, Masanori Hisaoka, and Hironori Haga
- Subjects
soft tissue neoplasms ,dedifferentiated liposarcoma ,cell trans-differentiation ,blood vessels ,MDM2 ,aSMA ,Medicine (General) ,R5-920 - Abstract
Dedifferentiated liposarcoma (DDLPS) is a non-lipogenic sarcoma, generally arising from well-differentiated liposarcoma (WDLPS), although it can develop de novo. DDLPS tumors rarely trans-differentiate into non-adipose mesenchymal tissues; however, the latter lack notable variety and mostly show striated muscle or osteogenic/chondrogenic differentiation. Here, we report a case of DDLPS that contained numerous atypical vessels. A man in his sixties presented with a large tumor in his right thigh, and the tumor was surgically resected. Microscopically, most of the tumor was WDLPS, but a minor portion showed DDLPS, consisting of high-grade spindle cells. Remarkably, the DDLPS contained vessels of various sizes with atypical cytoarchitecture, including vessels with seemingly muscular layers. Immunohistochemically, the atypical cells within the vascular wall expressed aSMA, consistent with smooth muscle cells or pericytes, whereas surrounding high-grade spindle cells only focally expressed it, and these aSMA-positive cells within the vessels exhibited MDM2 amplification by immuno-fluorescence in situ hybridization. Our results demonstrate that DDLPS can trans-differentiate into smooth muscle cells of various-sized accompanying vessels, which may support their survival and proliferation.
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- 2024
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23. Comparación clínica en el manejo remoto del asma bronquial durante la pandemia COVID-19 entre dos terapias controladoras: fluticasona y beclometasona
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Arturo Recabarren Lozada, Marcos Gustavo Llanos Rosas, and Gustavo Joel Llave Pinto
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Asma ,COVID-19 ,Glucocorticoides ,Consulta Remota ,Fluticasona ,Beclometasona ,Medicine - Abstract
Objetivo: Comparar el nivel de control del asma mediante el uso del Asthma Control Test (ACT) y manifestaciones clínicas en dos grupos de pacientes tratados con diferentes corticosteroides inhalados (GCI). Materiales y métodos. Estudio descriptivo, observacional y prospectivo donde se registró en 521 niños del programa de asma del Hospital III Yanahuara (Arequipa, Perú) el Nivel de Control del Asma, durante el periodo de junio del 2020 a diciembre 2021, por medio de la consulta remota empleando el ACT y la recopilación de los hallazgos clínicos (síntomas diurnos, nocturnos, visita a emergencias y uso de broncodilatadores beta 2 agonistas), en dos momentos durante la pandemia COVID-19. Resultados. Ambos grupos tuvieron un control óptimo al inicio y final del estudio, con una mejoría significativa en el último control (P < 0.05). En las manifestaciones clínicas no hubo una diferencia estadística (P > 0.05) en ambos controles. El nivel promedio del ACT de la Fluticasona al egreso, tuvo una superioridad significativa frente a la Beclometasona (P = 0.03). Conclusiones. La Teleconsulta es una herramienta eficaz para el monitoreo de enfermedades crónicas como lo es el asma. Tanto Fluticasona cómo Beclometasona lograron un control óptimo de la enfermedad, destacando que el verdadero factor determinante para lograr un buen control es el uso continuo de cualquier GCI. Sin embargo, se encontró una diferencia estadística significativa a favor de la Fluticasona; no obstante, por su menor precio, la relación costo-eficacia favorece a Beclometasona como opción económica y eficiente para un óptimo control del asma.
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- 2024
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24. Efeito da osteopatia nas patologias respiratórias: revisão sistemática
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David Ferreira, Mariana Costa, Miguel Couto, Rafaela Barreira, Sara Pereira, Natália Campelo, and Helena Sousa
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Patologias respiratórias ,asma ,doença pulmonar obstrutiva crónica ,pneumonia ,osteopatia ,tratamento manipulativo osteopático ,Medicine - Abstract
Introdução: As principais causas respiratórias de doença severa e morte a nível mundial são o cancro no pulmão, na traqueia e nos brônquios, a tuberculose, a doença pulmonar obstrutiva crónica (DPOC), a asma e a pneumonia, as quais são maioritariamente tratadas com a intervenção farmacológica. O tratamento manipulativo osteopático (TMO) tem vindo a ser relacionado com a melhoria da biomecânica da caixa torácica (Lago et al., 2015). Objetivo: Sistematizar a evidência disponível para determinar, mediante uma análise qualitativa da metodologia, os efeitos da intervenção osteopática na sintomatologia e qualidade de vida de indivíduos com patologias respiratórias, incluindo asma, DPOC, pneumonia, cancro da traqueia, pulmão e brônquios, além da tuberculose. Métodos: Procedeu-se a uma pesquisa sistemática na base de dados Pubmed a 30 de abril de 2022 e, com base nos critérios de inclusão e elegibilidade, selecionaram-se estudos experimentais randomizados e controlados. A análise dos artigos, recolha de dados e avaliação da qualidade metodológica, com recurso à Cochrane Risk of Bias Tool, foram realizadas por dois revisores independentes, intervindo um terceiro em caso de discordância (Donato & Donato, 2019). Resultados: Identificaram-se vinte e quatro ensaios clínicos randomizados (RCT), dos quais oito foram incluídos. Em relação à asma (Jones et al., 2021), verificaram-se melhorias estatisticamente significativas apenas num dos três artigos apurados. Nos três artigos relativos à DPOC, os investigadores verificaram melhorias significativas, porém, apenas em alguns dos parâmetros avaliados. Nos dois artigos referentes à pneumonia não se verificaram melhorias estatisticamente significativas. Os artigos apresentavam uma qualidade metodológica com alguns riscos de viés altos ou incertos. Conclusão: Pelas evidências estatisticamente significativas, parece indicar eficácia no uso de TMO na melhoria da sintomatologia e qualidade de vida de indivíduos com asma, DPOC e pneumonia. A qualidade metodológica dos estudos é limitada, pelo que não se pode assumir que a utilização da intervenção com recurso à TMO é eficaz na melhoria destas condições.
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- 2024
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25. Prevalencia de asma bronquial en pacientes infectados por virus sincitial respiratorio
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Kristell Franco, Eugenia Cevallos Velásquez, Vanessa Salazar, and Luis Arroba
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Asma ,Bronquiolitis ,Estudio Observacional ,Niño ,Virus Sincitiales Respiratorios ,Pediatrics ,RJ1-570 - Abstract
Introducción: El asma es la enfermedad no transmisible más frecuente en niños, el virus sincitial respiratorio (VSR) afecta en su mayoría a partir de los 2 años y es la principal causa de bronquiolitis en niños de todo el mundo. El objetivo del estudio fue establecer la prevalencia y relación entre el Asma Bronquial y VSR en pacientes preescolares. Métodos: Estudio descriptivo, analítico, observacional de corte transversal, no experimental, se realizó en el Hospital Dr. Francisco de Icaza Bustamante de la ciudad de Guayaquil en el periodo de enero 2017 a abril 2019. En el análisis estadístico se utilizó la prueba del Chi Cuadrado con un valor de significancia estadística
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- 2023
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26. High-flow nasal cannula and non-invasive mechanical ventilation in pediatric asthma exacerbation: two-year prospective observational study in intensive care.
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Delgado, Carolina S., García-Salido, Alberto, García-Teresa, María Á., Martínez de Azagra-Garde, Amelia, Leoz-Gordillo, Inés, de Lama Caro-Patón, Gema, and Nieto-Moro, Montserrat
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- *
NASAL cannula , *ARTIFICIAL respiration , *ASTHMA , *INTENSIVE care units , *HOSPITALS - Abstract
Background: Asthma is a common cause of admission to the pediatric intensive care unit (PICU). We described and analyzed the therapies applied to children admitted to a tertiary PICU because of asthma. Later, we evaluated high-flow nasal cannula (HFNC) use in these patients and compared their evolution and complications with those who received non-invasive ventilation. Methods: We conducted a prospective observational study (October 2017-October 2019). Collected data: epidemiological, clinical, respiratory support therapy needed, complementary tests, and PICU and hospital stay. Patients were divided into three groups: (1) only HFNC; (2) HFNC and non-invasive mechanical ventilation (NIMV); and (3) only NIMV. Results: Seventy-six patients were included (39 female). The median age was 2 years and 1 month. The median pulmonary score was 5. The median PICU stay was 3 days, and the hospital stay was 6 days. Children with HNFC only (56/76) had fewer PICU days (p = 0.025) and did not require NIMV (6/76). Children with HFNC had a higher oxygen saturation/fraction of inspired oxygen ratio ratio (p = 0.025) and lower PCO2 (p = 0.032). In the group receiving both therapies (14/76), NIMV was used first in all cases. No epidemiologic or clinical differences were found among groups. Conclusion: HFNC was a safe approach that did not increase the number of PICU or hospital days. On admission, normal initial blood gases and the absence of high oxygen requirements were useful in selecting responders to HFNC. Further randomized and multicenter clinical trials are needed to verify these data. [ABSTRACT FROM AUTHOR]
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- 2023
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27. Autoantibody Positivity Has No Impact on Histological Parameters in Nonalcoholic Fatty Liver Diseases.
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Jain, Kavita, Rastogi, Archana, Thomas, Sherin S., and Bihari, Chhagan
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- *
FATTY liver , *NON-alcoholic fatty liver disease , *AUTOANTIBODIES , *HEPATIC fibrosis , *ANTINUCLEAR factors , *OPTIMISM - Abstract
Previous reports on association of autoantibodies with histological severity in nonalcoholic fatty liver disease (NAFLD) have revealed inconsistent results. Therefore, this study was undertaken to find the impact of autoantibodies on histological severity of NAFLD. All cases with histological diagnosis of NAFLD during January 2016 to January 2021 were included in the study. Laboratory parameters were recorded, and histological assessment was done. The positivity of autoimmune markers was defined as presence of either antinuclear antibody (ANA; titer >1:80), anti-smooth muscle antibodies (ASMA), or anti-liver-kidney-microsomal antibodies (LKM-1; titer >1:40). Serum levels of CK18 - M30 and PIIINP were evaluated to assess the subtle changes in necroinflammatory activity and fibrosis in the liver. Autoantibodies were present in 281/683 (41.1%, 95% CI 37.4–44.9) patients. ANA, ASMA, ANA + ASMA was seen in 20.9% (95% CI 17.9–24.2); 14.5% (95% CI 11.9–17.4); and 5.7% (95% CI 4.1–7.7) cases, respectively. No significant difference was noted between the two groups in terms of age and metabolic tests. No significant difference was noted in the histological parameters between groups with autoantibodies positivity and no-positivity. Mean value of CK18-M30 between cases with negative autoantibody; ANA positivity; ASMA positivity; and combined positivity of autoantibody were 178.2 ± 81.8, 161.6 ± 63.7, 153.2 ± 70.3 and 169.8 ± 42.9, respectively (P = 0.57). However, CK18-M30 and PIIINP showed a rising trend with NAFL, NASH, NASH + AIH (P < 0.001). Autoantibodies noted in 41% NAFLD cases. No significant necroinflammatory activity or fibrosis associated with presence of antibodies in NAFLD cases. However, CK-18-M30 showed a rising trend from NAFL to NASH to NASH + AIH. [ABSTRACT FROM AUTHOR]
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- 2023
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28. Role of PDGF-B/PDGFR signalling in definitive haematopoiesis
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Sá Da Bandeira, Diana, Crisan, Mihaela, and Peault, Bruno
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616.02 ,HSCs ,haematopoietic stem cells ,PDGFRß ,NG2 ,aSMA ,PDGF-B/PDGFRß signalling ,germline deletion of PDGFRß ,perivascular stromal cells - Abstract
The first haematopoietic stem cells (HSCs) are generated in the dorsal aorta (DA) of the midgestation mouse embryo. Signals from the microenvironment are required for HSC generation. However, the signals and identity of cells releasing them in vivo remain unknown. In the present work, we identified at least three populations of perivascular cells surrounding the DA based on the expression of the perivascular cell markers NG2, PDGFRβ and αSMA. NG2+ PDGFRβ+ αSMA+ pericytes/vascular smooth muscle cells (PCs/vSMCs) and NG2- PDGFRβ+ αSMA- sub-pericytes (Sub-PCs) were found to be enriched in HSC-supportive genes described in the adult bone marrow (BM). As both populations express PDGFRβ, which has recently been shown to mediate HSC specification in zebrafish, and PDGF-B/PDGFRβ signalling is also required for the recruitment of pericytes to the developing blood vessel wall, we hypothesised that PDGF-B/PDGFRβ signalling is required to generate the first HSCs in vivo. To answer this question, we used PDGFRβ knock-out (KO) and PDGF-Bret KO mice, both of which have a defective pericyte recruitment to blood vessels and defective or absent PDGF-B/PDGFRβ signalling. Results from our haematopoietic progenitor assays (CFU-Cs) and transplantations show that the germline deletion of PDGFRβ affects both haematopoietic progenitor numbers and HSC activity in the E11 AGM. HSPCs in other haematopoietic organs are not affected at this stage. PDGF-Bret KO mice showed no defects in midgestation HSPCs, but AGM HSCs failed to reconstitute secondary recipients. Together, these data suggest that PDGFB/PDGFRβ signalling is required for AGM haematopoiesis. We found that perivascular stromal cells surrounding the DA are not affected by these mutations, nor the integrity of the blood vessel, suggesting that PDGFB/PDGFRβ signalling is not required for PC/vSMCs recruitment to the DA. We therefore hypothesised that PDGF-B/PDGFRβ signalling is either required in the niche for HSC specification and/or generation, and/or that PDGFRβ+ cells are precursors of HSCs. Tracing experiments using PDGFRβ-Cre;TdTomato mice found that a subset of AGM HSPCs derive from PDGFRβ-Cre precursors and that both Tomato- and Tomato+ E14 foetal liver (FL) and BM cells reconstitute irradiated recipients. Together these data suggest that adult HSCs have distinct developmental origins, one of them deriving from PDGFRβ+ cells. In conclusion, our results define PDGFRβ signalling as a key component of the HSC generating niche in the mouse embryo, and that a subset of HSCs derive from PDGFRβ+ precursors.
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- 2020
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29. Monitoramento pós-incorporação da utilização do Omalizumabe para o tratamento da asma alérgica grave no Sistema Único de Saúde
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Amanda Oliveira Lyrio, Laís Lessa Neiva Pantuzza, Samara Helena de Carvalho, Felipe Ferré, Tacila Pires Mega, Ana Carolina Freitas Lopes, and Luciene Fontes Schluckebier Bonan
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Sistema Único de Saúde ,Monitoramento ,Omalizumabe ,Asma ,Assistência Farmacêutica. ,Pharmacy and materia medica ,RS1-441 ,Pharmaceutical industry ,HD9665-9675 - Abstract
Introdução: A asma é uma doença crônica não transmissível associada à inflamação crônica das vias aéreas e hiperresponsividade a estímulos diretos e indiretos. O tratamento da doença é oferecido pelo Sistema Único de Saúde (SUS) de acordo com as diretrizes recomendadas pela Comissão Nacional de Incorporação de Tecnologias em Saúde (Conitec), publicadas em agosto de 2021. Entre os tratamentos disponíveis para a doença está o omalizumabe, indicado para asma alérgica grave descontrolada. Objetivo: Analisar o uso de omalizumabe para o tratamento da asma alérgica grave no SUS. Material e Método: Estudo de coorte aberta dos primeiros 12 meses de dispensação do omalizumabe no SUS, outubro de 2021 a setembro de 2022. Os dados utilizados consistem em informações retrospectivas do mundo real, de natureza administrativa e de âmbito nacional, relacionados com a dispensação de omalizumabe. Esses dados foram extraídos do Sistema de Informações Ambulatoriais do SUS (SIA/SUS) por meio da Sala Aberta de Inteligência em Saúde (Sabeis), desenvolvida pela Secretaria Executiva da Conitec. Foram incluídos todos os registros de dispensação de omalizumabe aprovados no SUS para asma alérgica grave, com a identificação criptografada do usuário. Resultados: Nos primeiros 12 meses, foram atendidos 892 pacientes, destes, 674 permaneceram ativos no último mês analisado (75%). No período de outubro de 2021 a setembro de 2022, a quantidade utilizada do medicamento no primeiro ano de utilização foi inferior à quantidade estimada, respectivamente, 13.670 e 158.000. A maioria dos indivíduos era do sexo feminino (67%) e a mediana de idade foi de 51 anos, o que está de acordo com as características de indivíduos com asma grave em outros estudos realizados no Brasil. Todas as regiões brasileiras tiveram registros de dispensação de medicamentos no primeiro ano de utilização, com maior frequência de usuários na região Sul (46%). Discussão e Conclusões: O monitoramento do omalizumabe revelou que os usuários possuem características similares à literatura. Observou-se que a maioria dos usuários identificados estavam em tratamento no último mês avaliado, o que indica alta persistência do tratamento Além disso, a quantidade utilizada foi menor que a estimada na incorporação. Essas análises são essenciais para gerar indicadores assistenciais e informar decisões sobre novos tratamentos no SUS, bem como para monitorar medicamentos já integrados.
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- 2023
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30. Perfil sociodemográfico e avaliação da técnica de utilização de dispositivos inalatórios no tratamento de doenças respiratórias em pacientes atendidos via CEAF
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Italo Henrique Medeiros Damasceno, Aliana Vitória Barbosa Carneiro, Laisla Lauanny Varela de Paiva, Anna Clara Barrêto Da Costa, Valdemária Abigail da Fonseca Ferreira, Rand Randall Martins, and Rodrigo dos Santos Diniz
- Subjects
Asma ,DPOC ,Técnica inalatória ,Dispositivos inalatórios ,Adesão ao tratamento. ,Pharmacy and materia medica ,RS1-441 ,Pharmaceutical industry ,HD9665-9675 - Abstract
Introdução: As doenças respiratórias (DRs) estão associadas à significativa parte das internações e óbitos ao redor do mundo, exigindo terapia constante para a garantia de uma boa qualidade de vida ao paciente e prevenção de exacerbações. O tratamento medicamentoso, por sua vez, comumente tem como base o uso de broncodilatadores e corticosteroides inalatórios. Esses fármacos são disponibilizados no Brasil via Componente Especializado da Assistência Farmacêutica (CEAF) para uso em Dispositivos Inalatórios (DIs). Com isso, o êxito terapêutico está diretamente relacionado à precisão da técnica inalatória. O desempenho do paciente na execução da técnica, entretanto, depende dos fatores mais diversos, que vão desde a orientação profissional no momento da dispensação, até seu próprio nível de instrução. Objetivos: Descrever o contexto sociodemográfico, adesão à terapia farmacológica e os principais erros de técnica no uso de DI em pacientes com DRs e acesso ao medicamento via CEA. Material e Método: Este estudo adota uma abordagem transversal e observacional, realizado com uma amostra de 42 pacientes adultos diagnosticados com asma e DPOC, atendidos via CEAF em Natal-RN. Utilizamos entrevistas estruturadas para coletar dados sociodemográficos dos participantes, através do questionário, bem como informações sobre a adesão à terapia e a técnica utilizada no manejo de Dispositivos Inalatórios. Resultados: Observou-se que a idade média dos participantes foi de 64,8 anos (+ 10,8), 57,1% dos participantes cursaram até o nível fundamental, mais de 75% possuem renda de até 1 salário mínimo e 47,6% relataram serem ex-fumantes. Na prevalência dos tipos de DI utilizados, tem-se o Aerolizer® (90,9%) e Ellipta® (9,1%). Adicionalmente, 59,5% apresentam adesão moderada à terapia medicamentosa. Dentre os principais erros de execução cometidos no uso de DI, destacam-se: a colocação incorreta do bocal na boca com o fechamento dos lábios de forma inadequada (87,5%) e a ausência do enxágue bucal após a inalação (85%) para o sistema Aerolizer®; a ausência da pausa pós-inalatória, de no mínimo 10 segundos, em todos os usuários do dispositivo Ellipta®. Discussão e Conclusões: No presente estudo foi observada a prevalência de pacientes em desvantagem socioeconômica com moderada adesão ao tratamento, além do uso incorreto dos DIs. Faz-se necessário implantação de consultórios farmacêuticos e capacitação de farmacêuticos, de forma a controlar e contornar a situação diante do progresso dessas comorbidades, além de garantir melhora significativa na qualidade de vida.
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- 2023
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31. PNEUMONIA EOSINOFÍLICA E PROVÁVEL SÍNDROME DE CHURG-STRAUSS: UM RELATO DE CASO
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Alícia Regina Zambiasi, Ana Katharina Dalbosco, Giordana Vitória Bertozzo Suzin, and Lucas Zambiasi
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Pneumonia ,Eosinofilia Pulmonar ,Síndrome de Churg-Strauss ,Eosinofilia ,Eosinófilos ,Asma ,Medicine - Abstract
As doenças pulmonares eosinofílicas compõe um grupo heterogêneo de patologias que possuem uma característica em comum: elevado número de eosinófilos nas vias aéreas e no parênquima pulmonar. Uma das formas de eosinofilia pulmonar é a Síndrome de Churg-Strauss (SCS), que é uma doença multissistêmica a qual possui evolução subaguda com três fases clínicas sequenciais: a prodrômica, a eosinofílica e a vasculítica. A hipótese diagnóstica pode ser considerada quando um padrão de opacidades em vidro fosco e consolidações são vistos em paciente com história de asma com eosinofilia.
- Published
- 2023
32. Treating asthma patients with probiotics: a systematic review and meta-analysis.
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Qiwei Xie, Jiatian Yuan, and Yaoweng Wang
- Subjects
- *
ASTHMATICS , *PROBIOTICS , *INHALERS , *ASTHMA in children , *DATABASE searching , *FORCED expiratory volume , *PNEUMONIA - Abstract
Objective: to evaluate the role of probiotics in the treatment of asthma patients by meta-analysis. Methods: PubMed, Embase, The Cochrane Library, Web of Science, and other databases were searched by computer, and the relevant literature on the treatment of asthma by probiotics that met the inclusion criteria was screened by manual retrieval. Meta-analysis was performed using Revman 5.4 software and the combined effect was evaluated by odds ratio (OR) or mean difference (MD) and 95 % confidence interval (CI). Results: a total of ten references were included, all of which were randomized controlled studies, and a total of 1,101 people were investigated. Fractional exhaled nitric oxide (FeNO) (MD = -7.17, 95 % CI: -12.81, -1.54), asthma symptom severity (MD = -0.07, 95 % CI: -0.10, -0.04), Childhood Asthma Control Test (CACT) (MD = 2.26, 95 % CI: 1.14, 3.39), and the number of acute episodes of asthma (OR = 0.30, 95 % CI: 0.19, 0.47) in the probiotics group were better than those in the control group. There was no significant difference in forced expiratory volume in the first second (FEV1) (MD = 0.11, 95 % CI: -0.05, 0.26) and FEV1/FVC (%) (MD = 0.32, 95 % CI: -1.48, 2.12). Conclusion: the use of probiotics in patients with asthma can improve lung inflammation and asthma symptoms, reduce the number of asthma attacks, and have no effect on lung function. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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33. The Effects of Gibberellic Acid and Cane Girdling of Applications on Crimson Seedless Grape Variety of Cluster and Berry Characteristics.
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Çoban, Harun
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GIBBERELLIC acid ,GRAPE varieties ,TREE girdling ,BERRIES ,SEEDLESS fruit - Abstract
Copyright of COMU Journal of Agriculture Faculty / ÇOMÜ Ziraat Fakültesi Dergisi is the property of Canakkale Onsekiz Mart University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2023
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34. Determination of Tolerance to Drought Stress of Two American Grapevine Rootstocks by PEG Application.
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İLHAN, Mert and BİLİR EKBİÇ, Hatice
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ROOTSTOCKS ,DROUGHT tolerance ,DROUGHT management ,ROOT development ,POLYETHYLENE glycol ,LEAF area ,GRAPES ,VITIS vinifera - Abstract
Copyright of Academic Journal of Agriculture / Akademik Ziraat Dergisi is the property of University of Ordu, Faculty of Agriculture, Academic Journal of Agriculture and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2023
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35. Hubungan Penderita Asma Perokok Pasif dengan Eksaserbasi Asma di RSUD M. Natsir Solok
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Alvin Muhammad, Oea Khairsyaf, and Endrinaldi Endrinaldi
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asma ,perokok pasif ,derajat eksaserbasi ,Medicine (General) ,R5-920 - Abstract
Latar Belakang: Asma merupakan penyakit kronis saluran napas yang dipicu oleh berbagai faktor, dan salah satunya adalah paparan asap rokok. Paparan asap rokok dapat meningkatkan risiko eksaserbasi asma dan juga dapat menyebabkan eksaserbasi asma. Objektif: Penelitian ini bertujuan untuk mengetahui hubungan anntara penderita asma perokok pasif dengan derajat eksaserbasi asma di RSUD M. Natsir Solok. Metode: Jenis penelitian ini adalah analitik observasional dengan desain studi potong lintang. Data dikumpulkan dengan metode wawancara menggunakan kuisioner kepada subjek asma. Data yang dikumpulkan berupa usia, jenis kelamin, pekerjaan, riwayat paparan asap rokok, dan derajat eksaserbasi asma. Sampel pada penelitian ini adalah 53 pasien asma perokok pasif yang memenuhi kriteria penelitian. Hasil: Sebanyak 15 (60%) orang yang terpapar asap rokok < 3 jam/hari mengalami eksaserbasi derajat sedang-berat, sedangkan orang yang terpapar asap rokok > 3 jam / hari yang mengalami eksaserbasi derajat sedang-berat berjumlah 26 orang (92,9%). Hasil uji statistik diperoleh nilai p = 0,012 dan nilai OR = 8,667. Kesimpulan: Terdapat hubungan antara penderita asma perokok pasif dengan derajat eksaserbasi asma.
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- 2022
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36. Gambaran Riwayat Asma pada Pasien Rinitis Alergi di RSUP Dr. M. Djamil Padang
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Dolly Irfandy, Muhammad Farhan Ramadhan, and Sabrina Ermayanti
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rinitis alergi ,asma ,united airway disease ,Medicine (General) ,R5-920 - Abstract
Latar Belakang: Rinitis alergi adalah penyakit inflamasi pada hidung yang sering ditemukan pada masyarakat. Asma merupakan salah satu komorbid yang dapat ditemukan pada penderita rinitis alergi. Hubungan rinitis alergi dan asma dijelaskan melalui konsep united airway disease. Objektif: Penelitian ini bertujuan untuk mengetahui gambaran dan karakteristik riwayat asma pada pasien rinitis alergi. Metode: Penelitian ini merupakan penelitian deskriptif retrospektif dengan desain cross-sectional. Penelitian ini dilakukan di RSUP Dr. M. Djamil Padang dengan jumlah sampel 78 pasien rinitis alergi. Hasil: Hasil penelitian didapatkan sebanyak 13 orang (16,7%) sampel memiliki riwayat asma. Karakteristik sampel dengan riwayat asma banyak ditemukan pada kelompok usia lebih dari 16 sampai 25 tahun (38,5%) dengan jenis kelamin terbanyak ditemukan pada perempuan (53,8%). Klasifikasi rinitis alergi persisten sedang-berat paling banyak ditemukan (46,2%). Gejala bersin-bersin ditemukan pada semua sampel dengan riwayat asma (100%). Riwayat atopi dalam keluarga ditemukan pada 12 orang (92,3%) sampel dengan riwayat asma. Kesimpulan: Kesimpulan penelitian ini yaitu riwayat asma ditemukan pada 1 dari 6 pasien rinitis alergi pada kelompok usia lebih dari 16 sampai 25 tahun. Pasien rinitis alergi dengan riwayat asma banyak ditemukan pada perempuan. Klasifikasi rinitis alergi terbanyak ditemukan berupa rinitis alergi persisten sedang-berat dengan gejala yang dominan yaitu bersin-bersin. Riwayat atopi dalam keluarga ditemukan pada sebagian besar pasien rinitis alergi disertai dengan riwayat asma.
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- 2022
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37. Care for people with Asthma: an integrative review.
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de Souza e. Sousa, Mariana Ellen, Evangelista Carnib Nascimento, Camila, Smith de Mesquita, Leonel Lucas, Batalha Sena, Luciana, Porto Brondani, Jeanine, Oliveira Silva, Andrea Cristina, Baluz Bezerra de Farias Nunes, Flávia, and de Ribamar Medeiros Lima Júnior, José
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HEALTH education ,ONLINE information services ,ASTHMA ,SYSTEMATIC reviews ,QUALITY of life ,DRUGS ,HEALTH care teams ,INTERPROFESSIONAL relations ,QUALITY assurance ,DESCRIPTIVE statistics ,PATIENT care ,MEDLINE ,PATIENT education ,PATIENT compliance ,DISEASE complications - Abstract
Copyright of Saúde Coletiva is the property of MPM Comunicacao and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2023
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38. Risk of vitamin D deficit in asthmatic children hospitalized in the north area of Santiago.
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Elena Herrera, María, Weisstaub, Gerardo, Herrera, Ana María, and Pinto, Ricardo
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HOSPITAL care of children , *VITAMIN D , *CHILEANS , *CHI-squared test , *VITAMIN D deficiency , *VITAMIN deficiency - Abstract
Introduction: in recent years asthma hospitalization rate in Chilean children has doubled. Numerous studies have shown an association between hypovitaminosis D and frequent, severe asthmatic exacerbations in children. Objective: to estimate the risk of vitamin D (vitD) deficiency and insufficiency in hospitalized asthmatic children compared with patients who are monitored on an outpatient basis and do not have records of hospitalization in one year. Material and methods: an observational, analytic, and case-control study carried out in one calendar year including asthmatic children between 5 and 15 years of age. This study registered: sociodemographic and clinical data, asthma control test, severity score of hospitalization and measurements of vitD blood levels. Associations between variables were analyzed using the t-test and chi-squared test. The risk for hypovitaminosis D and deficiency was calculated through logistic regression. The data was fed into the Stata 14 software. Results: a total of 117 patients, 9 ± 2.7 years old, were admitted, 64 % were male and 51 % presented with malnutrition by excess. Six out of ten children presented moderate asthma and 55 % had a poor control of their pathology; 73.5 % presented hypovitaminosis D (insufficiency and deficiency), hospitalized patients had 2.8 times more risk of presenting vitD deficiency, adjusted according to seasonality and age (95 %CI, 1.07-7.5, p < 0.05) without being associated with a higher severity score of hospitalization. Conclusion: most of the asthmatic children in the sample presented with hypovitaminosis D, with a higher percentage of deficiency in hospitalized patients, which is not associated with greater severity of hospitalization. [ABSTRACT FROM AUTHOR]
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- 2023
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39. Relação entre aleitamento materno e asma
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Victória Cristiny Freitas Santos and Emilly Peixoto Meira
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Aleitamento Materno ,Asma ,Controle de Infecções ,Social Sciences ,Medicine - Abstract
Objetivo: analisar a relação entre amamentação materna e asma. Materiais e Métodos: trata-se de uma revisão integrativa da literatura. Na primeira etapa foi formulada a seguinte questão norteadora: “O aleitamento materno exerce influência na prevenção da asma?”. Foi realizada a busca científica por meio das plataformas PubMed e Biblioteca Virtual em Saúde (BVS), utilizando os seguintes descritores indexados nos Descritores em Ciências da Saúde (DeCS): breast feeding, asthma e prevention and control, os quais foram agrupados utilizando-se o descritor booleano AND. Resultados: foram selecionados seis estudos publicados entre 2014 e 2022, realizados em diferentes países, como Estados Unidos, China, Paquistão, Noruega, Canadá e Japão. Os estudos utilizaram diferentes métodos, incluindo estudos de coorte, transversais e caso-controle. Foi demonstrado que a amamentação exclusiva por um período de quatro a seis meses está associada a um menor risco de desenvolvimento de asma em crianças pré-escolares. No entanto, a duração da amamentação por mais de seis meses não parece oferecer proteção significativa contra a asma. Além disso, a amamentação por mais de seis meses pode atenuar os efeitos de outros fatores de risco, como parto por cesariana e histórico familiar de alergia. Conclusão: o aleitamento materno pode exercer influência na prevenção da asma em crianças. No entanto, para obter conclusões mais sólidas, são necessários mais estudos, preferencialmente com amostras homogêneas, incluindo mecanismos subjacentes e a interação de outros fatores.
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- 2023
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40. Asociación de exposición a humo de camiones con asma en adolescentes de un centro de referencia del noreste de México
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Valeria González González, Sandra Nora González Díaz, Carlos Macouzet Sánchez, Laura Abigail Martínez Manzano, Rosa Ivett Guzmán Avilán, and Daniel Verduzco Félix
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Asma ,Camión ,Adolescente ,Contaminación ,Humo ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Objetivo: Comparar si los adolescentes que están expuestos a humo de camiones tienen mayor prevalencia de sintomatología de asma contra quienes no están expuestos. Métodos: Estudio transversal, descriptivo y comparativo. Se incluyeron adolescentes de 13 y 14 años de edad quienes completaron un cuestionario autoinformado. Los sujetos se seleccionaron siguiendo la misma metodología que en la fase III de ISAAC. Se les realizó una encuesta epidemiológica para la presencia de síntomas. Exposición al humo de camiones se definió como el paso de camiones la mayoría del día a percepción del paciente. La distribución fue evaluada con la prueba de Kolmogórov-Smirnov. Comparaciones con prueba de Chi-cuadrada o T de Student, según corresponda. Un valor de p £ 0.05 fue considerado estadísticamente significativo. Resultados: Se incluyeron un total de 492 pacientes. Las variables demográficas se pueden observar en la Tabla 1. Al realizar la asociación entre los grupos de adolescentes con asma que se encuentran expuestos a humo de camiones se encontró una diferencia significativa en la prevalencia de sintomatología respiratoria y asma (26.0% vs 9.6%, p = 0.000). Conclusión: Los pacientes adolescentes con asma que se encuentran expuestos al humo de camiones demostraron tener diferencia significativa en la presencia de sintomatología respiratoria y asma en comparación con los pacientes sin exposición. Palabras clave: Asma, camión, adolescentes, contaminación, humo.
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- 2023
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41. Variabilidad del patrón de sensibilidad alérgica en adultos mayores
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Juancarlos Manuel Velasquez Rodriguez and Gandhi Fernando Pavon Romero
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Asma ,sensibilidad ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Objetivo: Describir el patrón de sensibilidad alérgica en adultos mayores. Métodos: Se incluyeron AM (>60 años) con diagnóstico de enfermedad respiratoria alérgica en quienes se identificó la sensibilidad mediante prick con extractos ALK-abello (Port Washington, NY, Estados Unidos). Los resultados se analizaron mediante estadística descriptiva y se compararon con una serie de adultos jóvenes en relación 3:1. Los análisis de asociación se realizaron con prueba de χ2 usando el software SPSSv.21 (SPSS software, IBM, NY, EUA). Resultados: Se identificaron 17 AM, predominantes mujeres (70%) edad promedio de 64 años, 52% padecían asma y 47% rinitis alérgica, 82% eran polisensibles predominantemente intradomiciliares (82%), el más frecuente Dermatophagoides pteronyssinus (50%), disminuyendo a
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- 2023
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42. Efeito da osteopatia nas patologias respiratórias: revisão sistemática
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David Ferreira, Mariana Costa, Miguel Couto, Rafaela Barreira, Sara Pereira, Helena Sousa, and Natália Campelo
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Patologias respiratórias ,asma ,doença pulmonar obstrutiva crónica ,pneumonia ,osteopatia ,Medicine - Abstract
Introdução: As principais causas respiratórias de doença severa e morte a nível mundial são o cancro no pulmão, na traqueia e nos brônquios, a tuberculose, a doença pulmonar obstrutiva crónica (DPOC), a asma e a pneumonia. O tratamento manipulativo osteopático (TMO) tem vindo a ser relacionado com o relaxamento das vias aéreas, o tónus da musculatura lisa, melhoria biomecânica da caixa torácica. Objetivos: Determinar os efeitos da intervenção osteopática ao nível da sintomatologia e qualidade de vida de sujeitos com patologias respiratórias, nomeadamente asma, DPOC, pneumonia, cancro da traqueia, pulmão, brônquios e tuberculose. Material e Métodos: Procedeu-se a uma pesquisa sistemática na Pubmed a 30 de abril de 2022. Com base nos critérios de inclusão e elegibilidade, consideraram-se estudos experimentais randomizados e controlados (RCT). A seleção dos artigos, recolha de dados e avaliação da qualidade metodológica com a Cochrane Risk of Bias Tool, foram realizadas por dois revisores independentes, com terceiro em caso de discordância. Resultados: Identificaram-se 24 RCT. Foram incluídos oito, que apresentavam riscos de viés altos ou incertos. Não foram encontrados artigos relativos à tuberculose, cancros da traqueia, pulmão e brônquios. Relativamente à asma, num estudo, verificou-se um aumento médio de 4.8% no PEF no grupo TMO versus de 1.4% no grupo controlo. Num segundo estudo, quando comparado com o grupo controlo, o grupo TMO não houve resultados significativos. No terceiro estudo, os valores médios de FEF 25–75%, FVC, e FEV1 foram maiores no grupo TMO comparativamente ao grupo controlo. Relativamente à DPOC, num primeiro estudo, comparado com o grupo simulado, o grupo TMO apresentou uma diminuição no fluxo expiratório forçado a 25% e 50% da capacidade vital e na fase expiratória média, volume de reserva expiratório e resistência das vias aéreas. Num segundo estudo, no 6 Minute Walk Test, verificou-se no grupo TMO melhorias (p=0.01). Num terceiro estudo, a espirometria não apresentou valores significativos quanto a FVC e FEV1 total. Nos dois artigos da pneumonia não se observaram melhorias significativas. Conclusões: Os estudos sugerem eficácia da TMO na sintomatologia e qualidade de vida em algumas patologias respiratórios, contudo a qualidade metodológica é limitada.
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- 2023
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43. La necesidad de un abordaje integrado de la rinitis y el asma
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Ricardo José Saranz, Alejandro Lozano, Natalia Andrea Lozano, Graciela Alegre, Pilar Visconti, and Marina Flavia Ponzio
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asma ,rinitis alérgica ,costos de la atención en salud ,calidad de vida ,terapéutica ,Medicine ,Medicine (General) ,R5-920 - Abstract
Introducción: Numerosas evidencias sustentan el concepto de unidad de la vía aérea y sus consiguientes implicancias fisiopatológicas, clínicas y terapéuticas. La existencia de rinitis puede generar una mayor dificultad para el control del asma y mayores costos sanitarios directos e indirectos, lo que no es suficientemente reconocido por la mayoría de los médicos que las tratan, generalmente, como entidades separadas. Objetivo: Examinar evidencias testigos de la relación entre rinitis y asma que favorezcan el abordaje integrado de ambas patologías. Métodos: Se realizó una búsqueda bibliográfica en bases de datos PubMed (Medline), EBSCO, Scielo, Google Scholar utilizando términos MeSH y DeCS vinculados a la relación clínica y terapéutica entre rinitis y asma. Resultados: Finalmente se incluyeron 46 referencias bibliográficas que describen el impacto de la rinitis sobre la calidad de vida de pacientes con asma y su correlato terapéutico. Conclusiones: El tratamiento de ambas enfermedades fundamentado en un modelo integrado es imperativo. El reconocimiento endo-fenotípico conjunto y la decisión terapéutica consecuente permite en control simultáneo del asma y la rinitis y una disminución de su morbilidad. La adopción de medidas terapéuticas complementarias basadas en el concepto “una vía aérea, una única enfermedad” se corresponde con las buenas prácticas clínicas necesarias para lograr el mejor resultado terapéutico.
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- 2023
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44. Reabilitação respiratória na criança com asma: revisão sistemática
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Cláudia Andrade, Rosa Martins, and Nélia Carvalho
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asma ,criança ,enfermagem em reabilitação ,terapia respiratória ,exercícios respiratórios ,Special aspects of education ,LC8-6691 ,Public aspects of medicine ,RA1-1270 - Abstract
Introdução: A asma, é uma doença crónica caracterizada por inflamação e obstrução das vias aéreas, com grande prevalência e impacto na vida da criança, da família e comunidade A implementação de programas de Reabilitação Respiratória (RR) têm-se revelado positivos, porém de forma ainda incipiente. Objetivo: Mapear as evidências existentes sobre os efeitos da implementação de programas de Reabilitação Respiratória em crianças com asma entre os 6 e os 12 anos. Métodos: Revisão sistemática da literatura com base nos princípios preconizados pelo Joanna Briggs Institute. Foram pesquisados estudos publicados entre janeiro de 2015 e julho de 2020 em diferentes bases de dados. Dois revisores independentes realizaram a análise de relevância dos artigos, a extração e síntese final de dados de 5 artigos. Resultados: Os estudos incluíram essencialmente duas componentes da Reabilitação Respiratória: atividade física e exercício aeróbico. Os benefícios dos programas tiveram foco sobretudo ao nível do controlo da asma, da função pulmonar e da qualidade de vida da criança e da família. Conclusão: Os benefícios da RR em crianças com asma são uma evidência, com destaque para a função pulmonar, controlo de sintomas e qualidade de vida. A conceção e implementação de novos programas de RR serão um contributo valioso na promoção da saúde e qualidade de vida das pessoas.
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- 2023
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45. Vía aérea pequeña: de la definición al tratamiento
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Laura Gochicoa-Rangel, Carlos Adrián Jiménez-González, Irma Lechuga-Trejo, Rosaura Esperanza Benítez-Pérez, Ireri Thirión-Romero, Federico Isaac Hernández-Rocha, Omar Ceballos-Zúñiga, Arturo Cortés-Télles, Selene Guerrero-Zúñiga, Roberto Díaz-García, Aloisia Paloma Hernández-Morales, Jacqueline Lorena Aguilar-Zanela, and Luis Torre-Bouscoulet
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Vía aérea pequeña ,resistencia al flujo aéreo ,asma ,EPOC ,Immunologic diseases. Allergy ,RC581-607 - Abstract
La vía aérea pequeña, presente desde los orígenes de la humanidad y descrita hace apenas un siglo, se ha descubierto recientemente como el sitio anatómico donde inicia la inflamación provocada por algunas enfermedades pulmonares obstructivas: asma y enfermedad pulmonar obstructiva crónica (EPOC), per se. Se ha identificado disfunción de la vía aérea pequeña en el 91% de los pacientes asmáticos y en una gran proporción de quienes padecen EPOC. En los pacientes sin enfermedad, la vía aérea pequeña representa el 98.8% (4500 mL) del volumen pulmonar total, y solo aporta del 10 al 25% de la resistencia pulmonar total; sin embargo, en sujetos con obstrucción puede suponer el 90% de la resistencia total. A pesar de esto, sus características morfológicas y funcionales permiten que la disfunción pase inadvertida por métodos diagnósticos convencionales, por ejemplo la espirometría. Con base en lo anterior, el objetivo de este estudio fue revisar el panorama general de los métodos disponibles para evaluar la vía aérea pequeña y los posibles tratamientos asociados con esta zona silente. Palabras clave: Vía aérea pequeña; resistencia al flujo aéreo; asma; EPOC.
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- 2023
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46. Prevalencia de asma en pacientes hospitalizados por neumonía asociada a infección por SARS-CoV-2
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Beatriz Alejandra Paz-Velarde, Kevin Javier Arellano-Arteaga, Angie Bedolla-Pulido, Jaime Morales-Romero, Juan Manuel Rodríguez-Lizola, and Martín Bedolla-Barajas
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Asma ,COVID-19 ,Prevalencia ,SARS-CoV-2 ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Antecedentes: La asociación el asma con la COVID-19 continúa siendo controversial. Objetivo: establecer la prevalencia de asma en una muestra de pacientes con neumonía asociada COVID-19; además, describir las características clínicas de los pacientes con asma en comparación con los pacientes sin asma. Métodos: Se analizaron los datos clínicos correspondientes a120 pacientes hospitalizados por neumonía asociada a infección por SARS-CoV-2. Los pacientes con y sin asma fueron comparados en función de la gravedad de la COVID-19. Resultados: La prevalencia de asma en los pacientes con neumonía por COVID-19 fue del 3.5% (IC 95%: 1.5% a 9.6%). Al comparar la gravedad de la COVID-19 entre los pacientes con asma con los pacientes sin asma, ésta no difirió en función de los síntomas, la comorbilidad, la duración de los síntomas, la necesidad de ventilación mecánica asistida, los biomarcadores de inflamación y la ocurrencia de muerte. Los pacientes con asma y COVID-19 mostraron un fenotipo T2 alto, con pobre función respiratoria y sin uso de tratamiento regular para el control del asma. Conclusiones: No se observaron diferencias significativas en la frecuencia de la ventilación mecánica asistida o de la muerte entre los pacientes hospitalizados por neumonía asociada con COVID-19 con y sin historia de asma. Palabras clave: asma; COVID-19; prevalencia; SARS-CoV-2.
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- 2023
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47. Impact of Air Pollution on Asthma: A Scoping Review
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Olaia Bronte-Moreno, Francisco-Javier González-Barcala, Xavier Muñoz-Gall, Ana Pueyo-Bastida, Jacinto Ramos-González, and Isabel Urrutia-Landa
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Asma ,Contaminación ambiental ,Contaminante ,Exacerbación ,Material particulado ,Alergeno inhalado ,Diseases of the respiratory system ,RC705-779 - Abstract
Asthma is the most common chronic respiratory disease and a major public health problem. Although the causal relationship between air pollution and asthma remains controversial, a large number of studies have provided increasingly consistent evidence of the involvement of air pollutants in asthma onset and exacerbations. We conducted a keyword search-based literature review using PubMed, Scopus and Web of Science databases for studies with titles or abstracts containing predefined terms. This narrative review discusses the current evidence on the pathological effects of pollution throughout life and the mechanisms involved in the onset, development, and exacerbation of asthma, and presents current measures and interventions for pollution damage control. Further global efforts are still needed to improve air quality. Resumen: El asma es la enfermedad respiratoria crónica más común, y un importante problema de salud pública. Aunque la relación causal entre la contaminación del aire y el asma sigue siendo controvertida, una gran cantidad de estudios han proporcionado evidencia cada vez más consistente de la participación de los contaminantes del aire en el inicio y las exacerbaciones del asma. Realizamos una revisión de la literatura basada en búsqueda de palabras clave utilizando las bases de datos PubMed, Scopus y Web of Science para estudios con títulos o resúmenes que contienen términos predefinidos. Esta revisión narrativa analiza la evidencia actual sobre los efectos patológicos de la contaminación a lo largo de la vida y los mecanismos involucrados en el inicio, desarrollo y exacerbación del asma, y presenta las medidas e intervenciones actuales para el control de daños por contaminación. Todavía se necesitan más esfuerzos globales para mejorar la calidad del aire.
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- 2023
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48. HIPNOTERAPI SEBAGAI MEDIA PSIKOLOGIS BAGI PENDERITA ASMA.
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Afriyenti, Lenny Utama
- Abstract
This study aims to see the effectiveness of the benefits of hypnotherapy for asthma patients. The method used in this study uses a qualitative approach with a single case design, in which the subject has control over himself. One reason why using this method is because the researcher wants to study any changes that arise as a result of the hypnotherapy therapy given to the subject. A-B-A design is a type of design that expresses the change in outcome data from the initial phase to the intervention phase. Hypnotherapy is performed on patients using pattern matching where this is a form of data analysis used to compare conditions before and after therapy is given. From the results of counseling, the two subjects looked uncomfortable but looked enthusiastic about undergoing therapy which concluded that hypnotherapy using part therapy, object imagery, and dangpament therapy could help reduce the patient's feelings of depression which was offset by a decrease in the intensity of the patient's asthma. Hypnotherapy can help asthma sufferers to reduce the degree of depression and reduce asthma in sufferers. In the use of hypnotherapy also perform part therapy techniques, object imagery and donations. Descriptively, there were changes felt by asthma patients with three meetings of hypnotherapy with a duration of 45 minutes. The results showed that the intervention group experienced significant improvements in quality of life and reduced asthma symptoms such as shortness of breath and coughing compared to the control group. In addition, the intervention group also experienced decreased levels of anxiety and depression after the intervention. The conclusion of this study is that hypnotherapy can be an effective psychological medium for asthma sufferers in reducing symptoms and improving their quality of life. [ABSTRACT FROM AUTHOR]
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- 2023
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49. EVALUATION OF KNOWLEDGE ABOUT ASTHMA IN TECHNICAL-ADMINISTRATIVE PUBLIC WORKERS OF A PUBLIC UNIVERSITY.
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Rocha Mendes da Cruz, Ana Paula, Mocelin, Deyse, de Matos Magalhães, Bianca, Carvalho Coelho, Ana Carla, and de Souza-Machado, Carolina
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ASTHMA prevention , *HEALTH education , *ASTHMA , *CROSS-sectional method , *EXECUTIVES , *PUBLIC health , *CONTINUING education , *INTELLECT , *UNIVERSITIES & colleges , *QUESTIONNAIRES , *DESCRIPTIVE statistics , *RESEARCH funding , *INDUSTRIAL hygiene , *DATA analysis software - Abstract
Objective: to estimate the level of knowledge about asthma of technical-administrative public workers of graduate and postgraduate nursing courses of a public university in Salvador, Bahia. Method: cross-sectional study, conducted with 18 technical-administrative public workers of a public university. Data collection was performed by sending an email with links to the form in Google Forms, between January and May 2021. Data were analyzed using descriptive statistics using SPSS software, 28.0. Results: predominance of women, 77.8% (n=14), mean age 42.11±10.98 years. 55.6% (n=10) of the sample presented unsatisfactory knowledge about asthma in the analysis by domain and by the average of correct answers (X±SD=22.6±7.5 correct answers). Asthma treatment was the most unknown theme in the sample (X±SD=2.77±1.73 correct answers). Conclusion: the level of knowledge about asthma of technicaladministrative workers was unsatisfactory in the majority of the sample investigated. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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50. Consensus document on asthma and smoking of the Regional Asthma Forum of SEPAR.
- Author
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ÁLVAREZ-GUTIÉRREZ, FRANCISCO J., BLANCO-APARICIO, MARINA, SIGNES-COSTA, JAIME, PASTOR-ESPLÁ, ESTHER, GARCÍA-RIVERO, JUAN L., SOTO-CAMPOS, JOSÉ G., CALLEJAS-GONZÁLEZ, FRANCISCO J., ROMERO-PALACIOS, PEDRO JOSÉ, RIESCO-MIRANDA, JUAN A., and JIMÉNEZ-RUIZ, CARLOS A.
- Subjects
SMOKING ,ASTHMATICS ,BEHAVIOR therapy ,ASTHMA ,DIAGNOSIS ,COUGH - Abstract
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- Published
- 2023
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