1. Study of hepatic histomorphology in HBeAg+ and HBeAg− patients with CHB: Experience from Bangladesh
- Author
-
Ayub Al Mamun, Mamun-Al-Mahtab, S.M. Fazle Akbar, Kutub Uddin Mollick, Arun Jyoti Tarafdar, Faiz Ahmad Khondokar, Ahmed Lutful Mubin, Md. Helal Uddin, and Salimur Rahman
- Subjects
Histomorphology ,HBV ,HBeAg ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Objective: To compare Knodell and HAI scores in patients with wild type and pre-core/core promoter mutant CHB to see if there is any difference in severity of liver injury between these two types of HBV. Methods: We did percutaneous liver biopsies of 155 CHB patients. Of them 102 (65.8%) were infected wild type HBV and the rest 53 (34.2%) were infected with pre-core/core promoter mutant CHB. Results: 11/53 (20.8%) patients with pre-core/core promoter mutant CHB had moderate to severe CH (HAI score 8-18). In contrast, moderate to severe CH was seen in 19/102 (18.6%) patients with wild type CHB. Fibrosis score was >2 in 15/53 (28.3%) pre-core/core promoter mutant CHB as opposed to 20/102 (19.6%) patients with wild type CHB. Conclusions: The study shows that pre-core/core promoter mutant HBV produces more severe histological liver disease compared to wild type HBV.
- Published
- 2013
- Full Text
- View/download PDF