1. Chronic meningococcaemia and immunoglobulin A deficiency
- Author
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Cornelia Kuhnert, Julien Boileau, Jean-Christophe Weber, M. Rondeau-Lutz, Arnaud Theulin, Institut de recherches interdisciplinaires sur les sciences et la technologie (IRIST), Université de Strasbourg (UNISTRA), Laboratoire d'Histoire des Sciences et de Philosophie - Archives Henri Poincaré (LHSP), and Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Microbiology (medical) ,Bacteremia ,Neisseria meningitidis ,Biology ,Meningococcal disease ,medicine.disease_cause ,Microbiology ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,IgA deficiency ,030212 general & internal medicine ,IgM deficiency ,030304 developmental biology ,0303 health sciences ,Common variable immunodeficiency ,CRP - C-reactive protein ,Chronic meningococcaemia ,General Medicine ,Exanthema ,medicine.disease ,Immunoglobulin A ,3. Good health ,Immunoglobulin A deficiency ,Meningococcal Infections ,Common Variable Immunodeficiency ,Immunology ,Female ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
Chronic meningococcaemia is an unusual clinical presentation of Neisseria meningitidis infection. We describe the case of a patient, who presented with total IgA deficiency and partial IgM deficiency with a low switched memory B cells count, suggestive of a borderline form of common variable immunodeficiency (CVID). The role of IgA in the protection against Neisseria meningitidis, and the link between IgA deficiency and CVID are discussed.
- Published
- 2010