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534 results on '"Arnaldi, Dario"'

1. Validation of the International REM Sleep Behavior Disorder Study Group Symptoms Severity Scale (IRBD-SSS): a new tool to assess RBD clinical severity

Author

Fantini, Maria Livia, Postuma, Ronald B., Puligheddu, Monica, Rieu, Isabelle, Venel, Enguerrand, Figorilli, Michela, Cochen-DeCock, Valerie, Leclair-Visonneau, Laurene, Arnaldi, Dario, Mattioli, Pietro, Peter-Derex, Laure, Ricordeau, François, Terzaghi, Michele, Arnulf, Isabelle, Stefani, Ambra, Videnovic, Aleksandar, Chirol, Coline, and Pereira, Bruno

Published
2024
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3. Progression trajectories from prodromal to overt synucleinopathies: a longitudinal, multicentric brain [18F]FDG-PET study

Author

Orso, Beatrice, Mattioli, Pietro, Yoon, Eun-Jin, Kim, Yu Kyeong, Kim, Heejung, Shin, Jung Hwan, Kim, Ryul, Famà, Francesco, Brugnolo, Andrea, Massa, Federico, Chiaravalloti, Agostino, Fernandes, Mariana, Spanetta, Matteo, Placidi, Fabio, Pardini, Matteo, Bauckneht, Matteo, Morbelli, Silvia, Lee, Jee-Young, Liguori, Claudio, and Arnaldi, Dario

Published
2024
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6. Cerebrospinal fluid NPTX2 changes and relationship with regional brain metabolism metrics across mild cognitive impairment due to Alzheimer's disease

Author

Massa, Federico, Martinuzzo, Caterina, Gómez de San José, Nerea, Pelagotti, Virginia, Kreshpa, Wendy, Abu-Rumeileh, Samir, Barba, Lorenzo, Mattioli, Pietro, Orso, Beatrice, Brugnolo, Andrea, Girtler, Nicola, Vigo, Tiziana, Arnaldi, Dario, Serrati, Carlo, Uccelli, Antonio, Morbelli, Silvia, Chincarini, Andrea, Otto, Markus, and Pardini, Matteo

Published
2024
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7. Systemic inflammatory markers and volume of enhancing tissue on post-contrast T1w MRI images in differentiating true tumor progression from pseudoprogression in high-grade glioma

Author

Satragno, Camilla, Schiavetti, Irene, Cella, Eugenia, Picichè, Federica, Falcitano, Laura, Resaz, Martina, Truffelli, Monica, Caneva, Stefano, Mattioli, Pietro, Esposito, Daniela, Ginulla, Alessio, Scaffidi, Claudio, Fiaschi, Pietro, D’Andrea, Alessandro, Bianconi, Andrea, Zona, Gianluigi, Barletta, Laura, Roccatagliata, Luca, Castellan, Lucio, Morbelli, Silvia, Bauckneht, Matteo, Donegani, Isabella, Nozza, Paolo, Arnaldi, Dario, Vidano, Giulia, Gianelli, Flavio, Barra, Salvina, Bennicelli, Elisa, and Belgioia, Liliana

Published
2024
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8. Validation of the REM behaviour disorder phenoconversion-related pattern in an independent cohort

Author

Orso, Beatrice, Mattioli, Pietro, Yoon, Eun-Jin, Kim, Yu Kyeong, Kim, Heejung, Shin, Jung Hwan, Kim, Ryul, Liguori, Claudio, Famà, Francesco, Donniaquio, Andrea, Massa, Federico, García, David Vállez, Meles, Sanne K., Leenders, Klaus L., Chiaravalloti, Agostino, Pardini, Matteo, Bauckneht, Matteo, Morbelli, Silvia, Nobili, Flavio, Lee, Jee-Young, and Arnaldi, Dario

Published
2023
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9. Resting state electroencephalographic alpha rhythms are sensitive to Alzheimer’s disease mild cognitive impairment progression at a 6-month follow-up

Author

Babiloni, Claudio, Jakhar, Dharmendra, Tucci, Federico, Del Percio, Claudio, Lopez, Susanna, Soricelli, Andrea, Salvatore, Marco, Ferri, Raffaele, Catania, Valentina, Massa, Federico, Arnaldi, Dario, Famà, Francesco, Güntekin, Bahar, Yener, Görsev, Stocchi, Fabrizio, Vacca, Laura, Marizzoni, Moira, Giubilei, Franco, Yıldırım, Ebru, Hanoğlu, Lutfu, Hünerli, Duygu, Frisoni, Giovanni B., and Noce, Giuseppe

Published
2024
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11. Poor reactivity of posterior electroencephalographic alpha rhythms during the eyes open condition in patients with dementia due to Parkinson’s disease

Author

Babiloni, Claudio, Noce, Giuseppe, Tucci, Federico, Jakhar, Dharmendra, Ferri, Raffaele, Panerai, Simonetta, Catania, Valentina, Soricelli, Andrea, Salvatore, Marco, Nobili, Flavio, Arnaldi, Dario, Famà, Francesco, Buttinelli, Carla, Giubilei, Franco, Onofrj, Marco, Stocchi, Fabrizio, Vacca, Laura, Radicati, Fabiana, Fuhr, Peter, Gschwandtner, Ute, Ransmayr, Gerhard, Parnetti, Lucilla, Marizzoni, Moira, D'Antonio, Fabrizia, Bruno, Giuseppe, De Lena, Carlo, Güntekin, Bahar, Yıldırım, Ebru, Hanoğlu, Lutfu, Yener, Görsev, Hünerli, Duygu, Taylor, John-Paul, Schumacher, Julia, McKeith, Ian, Frisoni, Giovanni B., Antonini, Angelo, Ferreri, Florinda, Bonanni, Laura, De Pandis, Maria Francesca, and Del Percio, Claudio

Published
2024
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13. Different z-score cut-offs for striatal binding ratio (SBR) of DaT SPECT are needed to support the diagnosis of Parkinson’s Disease (PD) and dementia with Lewy bodies (DLB)

Author

Lanfranchi, Francesco, Arnaldi, Dario, Miceli, Alberto, Mattioli, Pietro, D’Amico, Francesca, Raffa, Stefano, Donegani, Maria Isabella, Chiola, Silvia, Massa, Federico, Pardini, Matteo, Di Raimondo, Tania, Sambuceti, Gianmario, Bauckneht, Matteo, Nobili, Flavio, and Morbelli, Silvia

Published
2023
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17. What a single electroencephalographic (EEG) channel can tell us about patients with dementia due to Alzheimer's disease

Author

Del Percio, Claudio, Noce, Giuseppe, Lopez, Susanna, Tucci, Federico, Carlin, Graziano, Lizio, Roberta, Musat, Andreea M., Soricelli, Andrea, Salvatore, Marco, Ferri, Raffaele, Nobili, Flavio, Arnaldi, Dario, Famà, Francesco, Buttinelli, Carla, Giubilei, Franco, Marizzoni, Moira, Güntekin, Bahar, Yener, Görsev, Stocchi, Fabrizio, Vacca, Laura, Frisoni, Giovanni B., and Babiloni, Claudio

Published
2022
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18. Evaluation of iron overload in nigrosome 1 via quantitative susceptibility mapping as a progression biomarker in prodromal stages of synucleinopathies

Author

Lancione, Marta, Donatelli, Graziella, Del Prete, Eleonora, Campese, Nicole, Frosini, Daniela, Cencini, Matteo, Costagli, Mauro, Biagi, Laura, Lucchi, Giacomo, Tosetti, Michela, Godani, Massimiliano, Arnaldi, Dario, Terzaghi, Michele, Provini, Federica, Pacchetti, Claudio, Cortelli, Pietro, Bonanni, Enrica, Ceravolo, Roberto, and Cosottini, Mirco

Published
2022
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21. Reactivity of posterior cortical electroencephalographic alpha rhythms during eyes opening in cognitively intact older adults and patients with dementia due to Alzheimer's and Lewy body diseases

Author

Babiloni, Claudio, Lorenzo, Ivan, Lizio, Roberta, Lopez, Susanna, Tucci, Federico, Ferri, Raffaele, Soricelli, Andrea, Nobili, Flavio, Arnaldi, Dario, Famà, Francesco, Buttinelli, Carla, Giubilei, Franco, Cipollini, Virginia, Onofrj, Marco, Stocchi, Fabrizio, Vacca, Laura, Fuhr, Peter, Gschwandtner, Ute, Ransmayr, Gerhard, Aarsland, Dag, Parnetti, Lucilla, Marizzoni, Moira, D'Antonio, Fabrizia, De Lena, Carlo, Güntekin, Bahar, Yıldırım, Ebru, Hanoğlu, Lutfu, Yener, Görsev, Gündüz, Duygu Hünerli, Taylor, John Paul, Schumacher, Julia, McKeith, Ian, Frisoni, Giovanni B., De Pandis, Maria Francesca, Bonanni, Laura, Percio, Claudio Del, and Noce, Giuseppe

Published
2022
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22. Opportunities and Pitfalls of REM Sleep Behavior Disorder and Olfactory Dysfunction as Early Markers in Parkinson's Disease.

Author

Orso, Beatrice, Brosse, Sarah, Frasnelli, Johannes, and Arnaldi, Dario

Subjects
SLEEP, RAPID eye movement sleep, PARKINSON'S disease, SLEEP disorders, SYMPTOMS, SMELL disorders
Abstract

During its pre-motor stage, Parkinson's disease (PD) presents itself with a multitude of non-motor symptoms with different degrees of specificity and sensitivity. The most important among them are REM sleep behavior disorder (RBD) and olfactory dysfunction. RBD is a parasomnia characterized by the loss of REM sleep muscle atonia and dream-enacting behaviors. Olfactory dysfunction in individuals with prodromal PD is usually described as hyposmia (reduced sense of smell) or anosmia (complete loss of olfactory function). These symptoms can precede the full expression of motor symptoms by decades. A close comprehension of these symptoms and the underlying mechanisms may enable early screening as well as interventions to improve patients' quality of life. Therefore, these symptoms have unmatched potential for identifying PD patients in prodromal stages, not only allowing early diagnosis but potentially opening a window for early, possibly disease-modifying intervention. However, they come with certain challenges. This review addresses some of the key opportunities and pitfalls of both RBD and olfactory dysfunction as early markers of PD. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Added value of semiquantitative analysis of brain FDG-PET for the differentiation between MCI-Lewy bodies and MCI due to Alzheimer’s disease

Author

Massa, Federico, Chincarini, Andrea, Bauckneht, Matteo, Raffa, Stefano, Peira, Enrico, Arnaldi, Dario, Pardini, Matteo, Pagani, Marco, Orso, Beatrice, Donegani, Maria Isabella, Brugnolo, Andrea, Biassoni, Erica, Mattioli, Pietro, Girtler, Nicola, Guerra, Ugo Paolo, Morbelli, Silvia, and Nobili, Flavio

Published
2022
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26. Pre-sleep arousal and sleep quality during the COVID-19 lockdown in Italy

Author

Arnaldi, Dario, Bonanni, Enrica, Bonetti, Giulio Alessandro, Castronovo, Cinzia, Maestri, Michelangelo, Garbarino, Sergio, Guarnieri, Biancamaria, Manni, Raffaele, Palagini, Laura, Puligheddu, Monica, Ferri, Raffaele, Silvani, Alessandro, Vicini, Claudio, Gorgoni, Maurizio, Scarpelli, Serena, Mangiaruga, Anastasia, Alfonsi, Valentina, Bonsignore, Maria R., Fanfulla, Francesco, Ferini-Strambi, Luigi, Nobili, Lino, Plazzi, Giuseppe, and De Gennaro, Luigi

Published
2021
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27. Biomarkers of conversion to α-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder

Author

Miglis, Mitchell G, Adler, Charles H, Antelmi, Elena, Arnaldi, Dario, Baldelli, Luca, Boeve, Bradley F, Cesari, Matteo, Dall'Antonia, Irene, Diederich, Nico J, Doppler, Kathrin, Dušek, Petr, Ferri, Raffaele, Gagnon, Jean-François, Gan-Or, Ziv, Hermann, Wiebke, Högl, Birgit, Hu, Michele T, Iranzo, Alex, Janzen, Annette, Kuzkina, Anastasia, Lee, Jee-Young, Leenders, Klaus L, Lewis, Simon J G, Liguori, Claudio, Liu, Jun, Lo, Christine, Ehgoetz Martens, Kaylena A, Nepozitek, Jiri, Plazzi, Giuseppe, Provini, Federica, Puligheddu, Monica, Rolinski, Michal, Rusz, Jan, Stefani, Ambra, Summers, Rebekah L S, Yoo, Dallah, Zitser, Jennifer, and Oertel, Wolfgang H

Published
2021
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31. Limbic Network Derangement Mediates Unawareness of Apathy in Mild Cognitive Impairment due to Alzheimer's Disease: Clues from [18F]FDG PET Voxel-Wise Analysis.

Author

Kreshpa, Wendy, Raffa, Stefano, Girtler, Nicola, Brugnolo, Andrea, Mattioli, Pietro, Orso, Beatrice, Calizzano, Francesco, Arnaldi, Dario, Peira, Enrico, Chincarini, Andrea, Tagliafico, Luca, Monacelli, Fiammetta, Calcagno, Pietro, Serafini, Gianluca, Gotta, Fabio, Mandich, Paola, Pretta, Stefano, Del Sette, Massimo, Sofia, Luca, and Sambuceti, Gianmario

Subjects
MILD cognitive impairment, ALZHEIMER'S disease, CINGULATE cortex, BRAIN metabolism, CAREGIVERS
Abstract

Background: Discrepancy between caregiver and patient assessments of apathy in mild cognitive impairment (MCI) is considered an index of apathy unawareness, independently predicting progression to AD dementia. However, its neural underpinning are uninvestigated. Objective: To explore the [18F]FDG PET-based metabolic correlates of apathy unawareness measured through the discrepancy between caregiver and patient self-report, in patients diagnosed with MCI. Methods: We retrospectively studied 28 patients with an intermediate or high likelihood of MCI-AD, progressed to dementia over an average of two years, whose degree of apathy was evaluated by means of the Apathy Evaluation Scale (AES) for both patients (PT-AES) and caregivers (CG-AES). Voxel-based analysis at baseline was used to obtain distinct volumes of interest (VOIs) correlated with PT-AES, CG-AES, or their absolute difference (DISCR-AES). The resulting DISCR-AES VOI count densities were used as covariates in an inter-regional correlation analysis (IRCA) in MCI-AD patients and a group of matched healthy controls (HC). Results: DISCR-AES negatively correlated with metabolism in bilateral parahippocampal gyrus, posterior cingulate cortex, and thalamus, PT-AES score with frontal and anterior cingulate areas, while there was no significant correlation between CG-AES and brain metabolism. IRCA revealed that MCI-AD patients exhibited reduced metabolic/functional correlations of the DISCR-AES VOI with the right cingulate gyrus and its anterior projections compared to HC. Conclusions: Apathy unawareness entails early disruption of the limbic circuitry rather than the classical frontal-subcortical pathways typically associated with apathy. This reaffirms apathy unawareness as an early and independent measure in MCI-AD, marked by distinct pathophysiological alterations. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Resting-state electroencephalographic delta rhythms may reflect global cortical arousal in healthy old seniors and patients with Alzheimer's disease dementia

Author

Babiloni, Claudio, Ferri, Raffaele, Noce, Giuseppe, Lizio, Roberta, Lopez, Susanna, Soricelli, Andrea, Nobili, Flavio, Arnaldi, Dario, Famà, Francesco, Orzi, Francesco, Buttinelli, Carla, Giubilei, Franco, Cipollini, Virginia, Marizzoni, Moira, Güntekin, Bahar, Aktürk, Tuba, Hanoğlu, Lutfu, Yener, Görsev, Emek-Savaş, Derya Durusu, Stocchi, Fabrizio, Vacca, Laura, Frisoni, Giovanni B., and Del Percio, Claudio

Published
2020
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38. Abnormalities of resting-state EEG in patients with prodromal and overt dementia with Lewy bodies: Relation to clinical symptoms

Author

Pascarelli, Maria Teresa, Del Percio, Claudio, De Pandis, Maria Francesca, Ferri, Raffaele, Lizio, Roberta, Noce, Giuseppe, Lopez, Susanna, Rizzo, Marco, Soricelli, Andrea, Nobili, Flavio, Arnaldi, Dario, Famà, Francesco, Orzi, Francesco, Buttinelli, Carla, Giubilei, Franco, Salvetti, Marco, Cipollini, Virginia, Franciotti, Raffaella, Onofri, Marco, Fuhr, Peter, Gschwandtner, Ute, Ransmayr, Gerhard, Aarsland, Dag, Parnetti, Lucilla, Farotti, Lucia, Marizzoni, Moira, D'Antonio, Fabrizia, De Lena, Carlo, Güntekin, Bahar, Hanoğlu, Lutfu, Yener, Görsev, Emek-Savaş, Derya Durusu, Triggiani, Antonio Ivano, Paul Taylor, John, McKeith, Ian, Stocchi, Fabrizio, Vacca, Laura, Hampel, Harald, Frisoni, Giovanni B., Bonanni, Laura, and Babiloni, Claudio

Published
2020
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41. Abnormal cortical neural synchronization mechanisms in quiet wakefulness are related to motor deficits, cognitive symptoms, and visual hallucinations in Parkinson's disease patients: an electroencephalographic study

Author

Babiloni, Claudio, Pascarelli, Maria Teresa, Lizio, Roberta, Noce, Giuseppe, Lopez, Susanna, Rizzo, Marco, Ferri, Raffaele, Soricelli, Andrea, Nobili, Flavio, Arnaldi, Dario, Famà, Francesco, Orzi, Francesco, Buttinelli, Carla, Giubilei, Franco, Salvetti, Marco, Cipollini, Virginia, Bonanni, Laura, Franciotti, Raffaella, Onofrj, Marco, Stirpe, Paola, Fuhr, Peter, Gschwandtner, Ute, Ransmayr, Gerhard, Aarsland, Dag, Parnetti, Lucilla, Farotti, Lucia, Marizzoni, Moira, D'Antonio, Fabrizia, De Lena, Carlo, Güntekin, Bahar, Hanoğlu, Lutfu, Yener, Görsev, Emek-Savaş, Derya Durusu, Triggiani, Antonio Ivano, Taylor, John Paul, McKeith, Ian, Stocchi, Fabrizio, Vacca, Laura, Hampel, Harald, Frisoni, Giovanni B., De Pandis, Maria Francesca, and Del Percio, Claudio

Published
2020
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45. Abnormalities of functional cortical source connectivity of resting-state electroencephalographic alpha rhythms are similar in patients with mild cognitive impairment due to Alzheimer's and Lewy body diseases

Author

Babiloni, Claudio, Del Percio, Claudio, Pascarelli, Maria Teresa, Lizio, Roberta, Noce, Giuseppe, Lopez, Susanna, Rizzo, Marco, Ferri, Raffaele, Soricelli, Andrea, Nobili, Flavio, Arnaldi, Dario, Famà, Francesco, Orzi, Francesco, Buttinelli, Carla, Giubilei, Franco, Salvetti, Marco, Cipollini, Virginia, Franciotti, Raffaella, Onofrj, Marco, Stirpe, Paola, Fuhr, Peter, Gschwandtner, Ute, Ransmayr, Gerhard, Aarsland, Dag, Parnetti, Lucilla, Farotti, Lucia, Marizzoni, Moira, D'Antonio, Fabrizia, De Lena, Carlo, Güntekin, Bahar, Hanoğlu, Lutfu, Yener, Görsev, Emek-Savaş, Derya Durusu, Triggiani, Antonio Ivano, Taylor, John Paul, McKeith, Ian, Stocchi, Fabrizio, Vacca, Laura, Hampel, Harald, Frisoni, Giovanni B., De Pandis, Maria Francesca, and Bonanni, Laura

Published
2019
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48. Presynaptic Dopaminergic Imaging Characterizes Patients with REM Sleep Behavior Disorder Due to Synucleinopathy.

Author

Arnaldi, Dario, Mattioli, Pietro, Raffa, Stefano, Pardini, Matteo, Massa, Federico, Iranzo, Alex, Perissinotti, Andres, Niñerola‐Baizán, Aida, Gaig, Carles, Serradell, Monica, Muñoz‐Lopetegi, Amaia, Mayà, Gerard, Liguori, Claudio, Fernandes, Mariana, Placidi, Fabio, Chiaravalloti, Agostino, Šonka, Karel, Dušek, Petr, Zogala, David, and Trnka, Jiri

Subjects
*DOPAMINERGIC imaging, *SLEEP, *RAPID eye movement sleep, *SLEEP disorders, *LEWY body dementia, *SMELL disorders, *POLYSOMNOGRAPHY
Abstract

Objective: To apply a machine learning analysis to clinical and presynaptic dopaminergic imaging data of patients with rapid eye movement (REM) sleep behavior disorder (RBD) to predict the development of Parkinson disease (PD) and dementia with Lewy bodies (DLB). Method s : In this multicenter study of the International RBD study group, 173 patients (mean age 70.5 ± 6.3 years, 70.5% males) with polysomnography‐confirmed RBD who eventually phenoconverted to overt alpha‐synucleinopathy (RBD due to synucleinopathy) were enrolled, and underwent baseline presynaptic dopaminergic imaging and clinical assessment, including motor, cognitive, olfaction, and constipation evaluation. For comparison, 232 RBD non‐phenoconvertor patients (67.6 ± 7.1 years, 78.4% males) and 160 controls (68.2 ± 7.2 years, 53.1% males) were enrolled. Imaging and clinical features were analyzed by machine learning to determine predictors of phenoconversion. Results: Machine learning analysis showed that clinical data alone poorly predicted phenoconversion. Presynaptic dopaminergic imaging significantly improved the prediction, especially in combination with clinical data, with 77% sensitivity and 85% specificity in differentiating RBD due to synucleinopathy from non phenoconverted RBD patients, and 85% sensitivity and 86% specificity in discriminating PD‐converters from DLB‐converters. Quantification of presynaptic dopaminergic imaging showed that an empirical z‐score cutoff of −1.0 at the most affected hemisphere putamen characterized RBD due to synucleinopathy patients, while a cutoff of −1.0 at the most affected hemisphere putamen/caudate ratio characterized PD‐converters. Interpretation: Clinical data alone poorly predicted phenoconversion in RBD due to synucleinopathy patients. Conversely, presynaptic dopaminergic imaging allows a good prediction of forthcoming phenoconversion diagnosis. This finding may be used in designing future disease‐modifying trials. ANN NEUROL 2024;95:1178–1192 [ABSTRACT FROM AUTHOR]

Published
2024
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50. Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms

Author

Babiloni, Claudio, Del Percio, Claudio, Lizio, Roberta, Noce, Giuseppe, Lopez, Susanna, Soricelli, Andrea, Ferri, Raffaele, Pascarelli, Maria Teresa, Catania, Valentina, Nobili, Flavio, Arnaldi, Dario, Famà, Francesco, Orzi, Francesco, Buttinelli, Carla, Giubilei, Franco, Bonanni, Laura, Franciotti, Raffaella, Onofrj, Marco, Stirpe, Paola, Fuhr, Peter, Gschwandtner, Ute, Ransmayr, Gerhard, Fraioli, Lucia, Parnetti, Lucilla, Farotti, Lucia, Pievani, Michela, D'Antonio, Fabrizia, De Lena, Carlo, Güntekin, Bahar, Hanoğlu, Lutfu, Yener, Görsev, Emek-Savaş, Derya Durusu, Triggiani, Antonio Ivano, Taylor, John Paul, McKeith, Ian, Stocchi, Fabrizio, Vacca, Laura, Frisoni, Giovanni B., and De Pandis, Maria Francesca

Published
2019
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