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Background: Cone-beam computed tomography (CBCT) has been introduced for breast-specimen imaging to identify a free resection margin of abnormal tissues in breast conservation. As well-known, typical micro CT consumes long acquisition and computation times. One simple solution to reduce the acquisition scan time is to decrease of the number of projections, but this method generates streak artifacts on breast specimen images. Furthermore, the presence of a metallic-needle marker on a breast specimen causes metal artifacts that are prominently visible in the images. In this work, we propose a deep learning-based approach for suppressing both streak and metal artifacts in CBCT. Methods: In this work, sinogram datasets acquired from CBCT and a small number of projections containing metal objects were used. The sinogram was first modified by removing metal objects and up sampling in the angular direction. Then, the modified sinogram was initialized by linear interpolation and synthesized by a modified neural network model based on a U-Net structure. To obtain the reconstructed images, the synthesized sinogram was reconstructed using the traditional filtered backprojection (FBP) approach. The remaining residual artifacts on the images were further handled by another neural network model, ResU-Net. The corresponding denoised image was combined with the extracted metal objects in the same data positions to produce the final results. Results: The image quality of the reconstructed images from the proposed method was improved better than the images from the conventional FBP, iterative reconstruction (IR), sinogram with linear interpolation, denoise with ResU-Net, sinogram with U-Net. The proposed method yielded 3.6 times higher contrast-to-noise ratio, 1.3 times higher peak signal-to-noise ratio, and 1.4 times higher structural similarity index (SSIM) than the traditional technique. Soft tissues around the marker on the images showed good improvement, and the mainly severe artifacts on the images were significantly reduced and regulated by the proposed. method. Conclusions: Our proposed method performs well reducing streak and metal artifacts in the CBCT reconstructed images, thus improving the overall breast specimen images. This would be beneficial for clinical use. [ABSTRACT FROM AUTHOR]

The quality of images obtained from cone-beam computed tomography (CBCT) is important in diagnosis and treatment planning for dental and maxillofacial applications. However, X-ray scattering inside a human head is one of the main factors that cause a drop in image quality, especially in the CBCT system with a wide-angle cone-beam X-ray source and a large area detector. In this study, the X-ray scattering distribution within a standard head phantom was estimated using the Monte Carlo method based on Geant4. Due to small variation of low-frequency scattering signals, the scattering signals from the head phantom can be represented as the simple predetermined scattering signals from a patient’s head and subtracted the projection data for scatter reduction. The results showed higher contrast and less cupping artifacts on the reconstructed images of the head phantom and real patients. Furthermore, the same simulated scattering signals can also be applied to process with higher-resolution projection data. [ABSTRACT FROM AUTHOR]

Soft tissue images from portable cone beam computed tomography (CBCT) scanners can be used for diagnosis and detection of tumor, cancer, intracerebral hemorrhage, and so forth. Due to large field of view, X-ray scattering which is the main cause of artifacts degrades image quality, such as cupping artifacts, CT number inaccuracy, and low contrast, especially on soft tissue images. In this work, we propose the X-ray scatter correction method for improving soft tissue images. The X-ray scatter correction scheme to estimate X-ray scatter signals is based on the deconvolution technique using the maximum likelihood estimation maximization (MLEM) method. The scatter kernels are obtained by simulating the PMMA sheet on the Monte Carlo simulation (MCS) software. In the experiment, we used the QRM phantom to quantitatively compare with fan-beam CT (FBCT) data in terms of CT number values, contrast to noise ratio, cupping artifacts, and low contrast detectability. Moreover, the PH3 angiography phantom was also used to mimic human soft tissues in the brain. The reconstructed images with our proposed scatter correction show significant improvement on image quality. Thus the proposed scatter correction technique has high potential to detect soft tissues in the brain. [ABSTRACT FROM AUTHOR]

Scatter signals in cone-beam computed tomography (CBCT) cause a significant problem that degrades image quality of reconstructed images, such as inaccuracy of CT numbers and cupping artifacts. In this paper, we will present an experiment-based scatter correction method by pre-processing projection images using a statistical model combined with experimental kernels. The convolution kernels are estimated by using different thickness of PMMA plates attached to a beam stop lead sheet such that the scatter signal values can be measure in the shadow area of the projection images caused by the lead sheet. The scatter signal values of different thickness levels can be measured in the shadow area of projection images caused by the lead sheet. Then, the projection images are convolved with the kernels that are derived from the actual measurement of scatter signals in PMMA plates. Finally, the primary signals can be estimated using the maximum likelihood expectation maximization method. Experimental results by using the proposed method show that the quality of the reconstruction images is significantly improved. The CT numbers become more accurate and the cupping artifact is reduced.

Cone-beam computed tomography (CBCT) has become increasingly popular in dental and maxillofacial imaging due to its accurate 3D information, minimal radiation dose, and low machine cost. In this paper, we have proposed the newly developed CBCT scanner, called DentiiScan. Our gantry system consisting of a cone-beam X-ray source and an amorphous silicon flat panel detector is rotated around a patient's head. With the large area detector, only a single rotation is needed to reconstruct the field-of-view area from chin to eyes and our reconstructed algorithm based on GPU calculation is about 30 times faster than the CPU-based algorithm. The radiation dose was measured and compared to other dental and medical CT machines. The absorbed radiation dose from our proposed CBCT machine is significantly low. In addition, geometric accuracy was analyzed when the test object was scanned at the normal position as well as the inclined position. The results from three observers repeated for five times confirm that the machine can produce reconstructed images with high accuracy.

CT reconstruction from metal-embedded data usually produces streak artifacts that reduce the quality of the reconstructed images. In this paper, we propose a new technique for metal artifact reduction in cone-beam CT based on statistical reconstruction. First, the metal objects are segmented in the reconstructed images and then reprojected to obtain the measurement data of the metal objects using cone-beam reconstruction. The original measurement data in the metal area are corrected through cubic interpolation. y, the corrected measurement data are reconstructed with the penalized likelihood using the modified convex algorithm. The simulation results show that the reconstructed images of the metal object using the proposed metal artifact reduction technique are superior to conventional filtered backprojection reconstruction.