1. The 'Effects of Transfusion Thresholds on Neurocognitive Outcome of Extremely Low Birth-Weight Infants (ETTNO)' Study : Background, Aims, and Study Protocol
- Author
-
Erik W. van Zwet, Sandra Heck, E. Kieran, F.J. Walther, Gabrielle C. Musk, Tim Schindler, Han Suk Kim, Hyun Ju Lee, Michael O’Reilly, Rangmar Goelz, Irene T.M. Lindenburg, Magnar Bjørås, E.E.M. Mulder, Rhonda J. Rosychuk, Ola Didrik Saugstad, Andreas Ohlin, Vivianne E.H.J. Smits-Wintjens, Joerg Fuchs, Frans J. Walther, Ertan Mayatepek, Rønnaug Solberg, M. Moll, Dick Oepkes, Frank Pillekamp, Yong Song, Anders Bäckman, Ee-Kyung Kim, Satz Mengensatzproduktion, E.J. Molloy, Carmen Eicher, Jung-Hwan Choi, Yngve Sejersted, Thierry Lacaze-Masmonteil, Uwe Ewald, Monika Olischar, Y.S. Prakash, Aaron Hamvas, Mirjam E.A. Rath, A.B. te Pas, D. Noone, Guido Seitz, Thomas Hoehn, Berit Hadzik, Kei Lui, S. Minocchieri, Katherine J Lee, Rod W. Hunt, Richard J. Martin, Veronika Tosse, Neama Meriki, Brent Reyburn, Joerg Arand, Alec W. Welsh, Graeme R. Polglase, Pablo Verde, John Smyth, Peter M. MacFarlane, M. Rijken, E. Lopriore, Druck Reinhardt Druck Basel, Beyong Il Kim, Peter A. Dargaville, Andrew Davidson, J. Jane Pillow, Enrico Lopriore, Maria Björkqvist, Jens Schollin, Embjørg J. Wollen, Ann Hudson-Mason, Hemmen Sabir, Christian F. Poets, Chang Won Choi, Andrea Bevot, Stein, Anja (Beitragende*r), Keller, Matthias (Beitragende*r), and Hüning, Britta Maria (Beitragende*r)
- Subjects
Protocol (science) ,Pediatrics ,medicine.medical_specialty ,business.industry ,MEDLINE ,Medizin ,medicine.disease ,Anemia of prematurity ,law.invention ,Very preterm ,Low birth weight ,Randomized controlled trial ,law ,Pediatrics, Perinatology and Child Health ,medicine ,medicine.symptom ,business ,Intensive care medicine ,Neurocognitive ,Developmental Biology - Abstract
Background: Infants with extremely low birth weight uniformly develop anemia of prematurity and frequently require red blood cell transfusions (RBCTs). Although RBCT is widely practiced, the indications remain controversial in the absence of conclusive data on the long-term effects of RBCT. Objectives: To summarize the current equipoise and to outline the study protocol of the ‘Effects of Transfusion Thresholds on Neurocognitive Outcome of extremely low birth-weight infants (ETTNO)’ study. Methods: Review of the literature and design of a large pragmatic randomized controlled trial of restrictive versus liberal RBCT guidelines enrolling 920 infants with birth weights of 400–999 g with long-term neurodevelopmental follow-up. Results and Conclusions: The results of ETTNO will provide definite data about the efficacy and safety of restrictive versus liberal RBCT guidelines in very preterm infants.
- Published
- 2012