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1. SARS-CoV-2 Breakthrough Infections: Incidence and Risk Factors in a Large European Multicentric Cohort of Health Workers

Author

Stefano Porru, Maria Grazia Lourdes Monaco, Gianluca Spiteri, Angela Carta, Maria Diletta Pezzani, Giuseppe Lippi, Davide Gibellini, Evelina Tacconelli, Ilaria Dalla Vecchia, Emma Sala, Emanuele Sansone, Giuseppe De Palma, Carlo Bonfanti, Massimo Lombardo, Luigina Terlenghi, Enrico Pira, Ihab Mansour, Maurizio Coggiola, Catalina Ciocan, Alessandro Godono, Adonina Tardon, Marta-Maria Rodriguez-Suarez, Guillermo Fernandez-Tardon, Francisco-Jose Jimeno-Demuth, Rafael-Vicente Castro-Delgado, Tania Iglesias Cabo, Maria Luisa Scapellato, Filippo Liviero, Angelo Moretto, Paola Mason, Sofia Pavanello, Anna Volpin, Luigi Vimercati, Silvio Tafuri, Luigi De Maria, Stefania Sponselli, Pasquale Stefanizzi, Antonio Caputi, Fabriziomaria Gobba, Alberto Modenese, Loretta Casolari, Denise Garavini, Cristiana D’Elia, Stefania Mariani, Francesca Larese Filon, Luca Cegolon, Corrado Negro, Federico Ronchese, Francesca Rui, Paola De Michieli, Nicola Murgia, Marco Dell’Omo, Giacomo Muzi, Tiziana Fiordi, Angela Gambelunghe, Ilenia Folletti, Dana Mates, Violeta Claudia Calota, Andra Neamtu, Ovidiu Perseca, Catalin Alexandru Staicu, Angelica Voinoiu, Eleonóra Fabiánová, Jana Bérešová, Zora Kľocová Adamčáková, Roman Nedela, Anna Lesňáková, Jana Holčíková, Paolo Boffetta, Mahsa Abedini, Giorgia Ditano, Shuffield Seyram Asafo, Giovanni Visci, Francesco Saverio Violante, Carlotta Zunarelli, and Giuseppe Verlato

Subjects
breakthrough infections, health workers, COVID-19, occupational and socio-demographic determinants, SARS-CoV-2 vaccination, Medicine
Abstract

Background: The research aimed to investigate the incidence of SARS-CoV-2 breakthrough infections and their determinants in a large European cohort of more than 60,000 health workers. Methods: A multicentric retrospective cohort study, involving 12 European centers, was carried out within the ORCHESTRA project, collecting data up to 18 November 2021 on fully vaccinated health workers. The cumulative incidence of SARS-CoV-2 breakthrough infections was investigated with its association with occupational and social–demographic characteristics (age, sex, job title, previous SARS-CoV-2 infection, antibody titer levels, and time from the vaccination course completion). Results: Among 64,172 health workers from 12 European health centers, 797 breakthrough infections were observed (cumulative incidence of 1.2%). The primary analysis using individual data on 8 out of 12 centers showed that age and previous infection significantly modified breakthrough infection rates. In the meta-analysis of aggregated data from all centers, previous SARS-CoV-2 infection and the standardized antibody titer were inversely related to the risk of breakthrough infection (p = 0.008 and p = 0.007, respectively). Conclusion: The inverse correlation of antibody titer with the risk of breakthrough infection supports the evidence that vaccination plays a primary role in infection prevention, especially in health workers. Cellular immunity, previous clinical conditions, and vaccination timing should be further investigated.

Published
2022
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2. Profile of common prostate cancer risk variants in an unscreened Romanian population

Author

Thorunn Rafnar, Viorel Jinga, Stefan Rascu, Viorica Radoi, Daniel Badescu, Stefania Benonisdottir, Bjarni V. Halldorsson, Angelica Voinoiu, Radu Ursu, Hannes P. Eggertsson, Bjarni Gunnarsson, Paul D. Iordache, Razvan Danau, Cătălin Alexandru Staicu, Irma Eva Csiki, Mariana Jinga, Violeta Calota, Dana Mates, Nicoleta Suciu, Patrick Sulem, Daniel Radavoi, Gabriel Rosoga, Kari Stefansson, Sorin Cristian Sima, Andrei Manolescu, Júlíus Guðmundsson, Læknadeild (HÍ), Faculty of Medicine (UI), Tækni- og verkfræðideild (HR), School of Science and Engineering (RU), School of Health Sciences (UI), Heilbrigðisvísindasvið (HÍ), Háskólinn í Reykjavík, Reykjavik University, Háskóli Íslands, and University of Iceland

Subjects
0301 basic medicine, Male, Erfðagreining, Genome-wide association study, unscreened population, Unscreened population, Genome-wide association studies, Prostate cancer, Gene Frequency, GWAS, genome‐wide association study, Oligonucleotide Array Sequence Analysis, Genetics, Prostate cancer risk, Aged, 80 and over, education.field_of_study, Middle Aged, prostate cancer, 3. Good health, Molecular Medicine, Population study, Original Article, Risk, Population, Single-nucleotide polymorphism, Blöðruhálskirtilskrabbamein, Biology, Polymorphism, Single Nucleotide, 03 medical and health sciences, medicine, Biomarkers, Tumor, SNP, Erfðafræði, Humans, Genetic Predisposition to Disease, 1000 Genomes Project, education, Alleles, Aged, Neoplasm Staging, Romania, Genome, Human, Gene Expression Profiling, Prostatic Neoplasms, Cell Biology, Rannsóknir, Original Articles, Prostate-Specific Antigen, medicine.disease, 030104 developmental biology, Genetic Loci, Case-Control Studies, Genome-Wide Association Study
Abstract

To find sequence variants affecting prostate cancer (PCA) susceptibility in an unscreened Romanian population we use a genome‐wide association study (GWAS). The study population included 990 unrelated pathologically confirmed PCA cases and 1034 male controls. DNA was genotyped using Illumina SNP arrays, and 24.295.558 variants were imputed using the 1000 Genomes data set. An association test was performed between the imputed markers and PCA. A systematic literature review for variants associated with PCA risk identified 115 unique variants that were tested in the Romanian sample set. Thirty of the previously reported SNPs replicated (P‐value < 0.05), with the strongest associations observed at: 8q24.21, 11q13.3, 6q25.3, 5p15.33, 22q13.2, 17q12 and 3q13.2. The replicated variants showing the most significant association in Romania are rs1016343 at 8q24.21 (P = 2.2 × 10−4), rs7929962 at 11q13.3 (P = 2.7 × 10−4) and rs9364554 at 6q25.2 (P = 4.7 × 10−4). None of the variants tested in the Romanian GWAS reached genome‐wide significance (P‐value, This study was funded in part by the European Union FP7 Program (ProMark project 202059) and by the EEA grant (ROMCAN project RO14-0017; EEAJRPRO-NO-20131-10191).

Published
2017

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