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UO2 is an antiferromagnetic Mott-Hubbard insulator and exhibits piezomagnetism, though the origin of this is elusive. Here, X-ray diffraction of UO2 in pulsed magnetic fields reveals the presence of time-reversed magnetic domains and structural distortions that take place during the piezomagnetic switching.

Abstract c‐MYC controls more than 15% of genes responsible for proliferation, differentiation, and cellular metabolism in pancreatic as well as other cancers making this transcription factor a prime target for treating patients. The transcriptome of 55 patient‐derived xenografts show that 30% of them share an exacerbated expression profile of MYC transcriptional targets (MYC‐high). This cohort is characterized by a high level of Ki67 staining, a lower differentiation state, and a shorter survival time compared to the MYC‐low subgroup. To define classifier expression signature, we selected a group of 10 MYC target transcripts which expression is increased in the MYC‐high group and six transcripts increased in the MYC‐low group. We validated the ability of these markers panel to identify MYC‐high patient‐derived xenografts from both: discovery and validation cohorts as well as primary cell cultures from the same patients. We then showed that cells from MYC‐high patients are more sensitive to JQ1 treatment compared to MYC‐low cells, in monolayer, 3D cultured spheroids and in vivo xenografted tumors, due to cell cycle arrest followed by apoptosis. Therefore, these results provide new markers and potentially novel therapeutic modalities for distinct subgroups of pancreatic tumors and may find application to the future management of these patients within the setting of individualized medicine clinics.

Este artículo analiza cómo utilizan las Tecnologías de la Información y la Comunicación (TIC) en sus actividades académicas los profesores de tiempo completo, medio tiempo y por horas de la Benemérita Universidad Autónoma de Puebla (BUAP). En la investigación, de corte cuantitativo con un diseño correlacional, participaron 71 profesores, a quienes se les aplicó un cuestionario compuesto por 26 reactivos. Los resultados obtenidos indican que los profesores contratados por hora y en un rango de edad entre 25 a 38 años tienden a hacer un mayor uso de las TIC. En cuanto a las tecnologías más utilizadas por los profesores se encontraron: el correo electrónico, las presentaciones multimedia y las páginas web generales; mientras que las menos utilizadas son los foros, laboratorios virtuales y las videoconferencias.