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3. BACH1 promotes tissue necrosis and Mycobacterium tuberculosis susceptibility

Author

Amaral, Eduardo P., Namasivayam, Sivaranjani, Queiroz, Artur T. L., Fukutani, Eduardo, Hilligan, Kerry L., Aberman, Kate, Fisher, Logan, Bomfim, Caio Cesar B., Kauffman, Keith, Buchanan, Jay, Santuo, Leslie, Gazzinelli-Guimaraes, Pedro Henrique, Costa, Diego L., Teixeira, Mariane Araujo, Barreto-Duarte, Beatriz, Rocha, Clarissa Gurgel, Santana, Monique Freire, Cordeiro-Santos, Marcelo, Barber, Daniel L., Wilkinson, Robert J., Kramnik, Igor, Igarashi, Kazuhiko, Scriba, Thomas, Mayer-Barber, Katrin D., Andrade, Bruno B., and Sher, Alan

Published
2024
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6. An integrative multi-omics approach to characterize interactions between tuberculosis and diabetes mellitus

Author

Vinhaes, Caian L., Fukutani, Eduardo R., Santana, Gabriel C., Arriaga, María B., Barreto-Duarte, Beatriz, Araújo-Pereira, Mariana, Maggitti-Bezerril, Mateus, Andrade, Alice M.S., Figueiredo, Marina C., Milne, Ginger L., Rolla, Valeria C., Kristki, Afrânio L., Cordeiro-Santos, Marcelo, Sterling, Timothy R., Andrade, Bruno B., and Queiroz, Artur T.L.

Published
2024
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8. Effect of the relationship between anaemia and systemic inflammation on the risk of incident tuberculosis and death in people with advanced HIV: a sub-analysis of the REMEMBER trial

Author

Araújo-Pereira, Mariana, Krishnan, Sonya, Salgame, Padmini, Manabe, Yukari C., Hosseinipour, Mina C., Bisson, Gregory, Severe, Damocles Patrice, Rouzier, Vanessa, Leong, Samantha, Mave, Vidya, Sawe, Fredrick Kipyego, Siika, Abraham M., Kanyama, Cecilia, Dadabhai, Sufia S., Lama, Javier R., Valencia-Huamani, Javier, Badal-Faesen, Sharlaa, Lalloo, Umesh Gangaram, Naidoo, Kogieleum, Mohapi, Lerato, Kityo, Cissy, Andrade, Bruno B., and Gupta, Amita

Published
2023
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9. Anemia and anti-tuberculosis treatment outcome in persons with pulmonary tuberculosis: A multi-center prospective cohort study

Author

Andrade, Alice M.S., Nascimento, Vanessa, Cubillos-Angulo, Juan Manuel, Malta-Santos, Hayna, Rebouças-Silva, Jéssica, Santos, Saulo R.N., Ramos, André, Brito, Pedro, Schmaltz, Carolina A.S., Costa, Alysson G., Sousa Garcia, Leandro, de Sousa Carvalho, Brenda K., de Loiola, Bruna P., Gomes-Silva, Adriano, Ignácio, Francine P., Lourenço, Maria C., Silva, Elisangela C., Mello, Mayla, Souza, Alexandra B., Barreto-Duarte, Beatriz, Rocha, Michael S., Benjamin, Aline, Moreira, Adriana S.R., de Oliveira, Jamile G., Cavalcante, Solange, Durovni, Betina, Lapa-e-Silva, José R., Araújo-Pereira, Mariana, Nogueira, Betânia M.F., Spener-Gomes, Renata, Carvalho, Anna C.C., Sant’Anna, Flávia Marinho, Figueiredo, Marina C., Turner, Megan M., Kritski, Afrânio L., Cordeiro-Santos, Marcelo, Rolla, Valeria C., Sterling, Timothy R., and Andrade, Bruno B.

Published
2023
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10. Determinants of losses in the tuberculosis infection cascade of care among children and adolescent contacts of pulmonary tuberculosis cases: A Brazilian multi-centre longitudinal study

Author

Sobral, Luciana, Arriaga, María B., Souza, Alexandra B., Araújo-Pereira, Mariana, Barreto-Duarte, Beatriz, Sales, Caio, Rocha, Michael S., Benjamin, Aline, Moreira, Adriana S.R., de Oliveira, Jamile G., Carvalho, Anna Cristina, Spener-Gomes, Renata, Figueiredo, Marina C., Cavalcante, Solange, Durovni, Betina, Lapa-e-Silva, José R., Kritski, Afrânio L., Rolla, Valeria C., Sterling, Timothy R., Cordeiro-Santos, Marcelo, and Andrade, Bruno B.

Published
2022
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11. Platelet-monocyte interaction amplifies thromboinflammation through tissue factor signaling in COVID-19

Author

Hottz, Eugenio D., Martins-Gonçalves, Remy, Palhinha, Lohanna, Azevedo-Quintanilha, Isaclaudia G., de Campos, Mariana M., Sacramento, Carolina Q., Temerozo, Jairo R., Soares, Vinicius Cardoso, Dias, Suelen S. Gomes, Teixeira, Lívia, Castro, Ícaro, Righy, Cassia, Souza, Thiago Moreno L., Kurtz, Pedro, Andrade, Bruno B., Nakaya, Helder I., Monteiro, Robson Q., Bozza, Fernando A., and Bozza, Patrícia T.

Published
2022
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15. Retreatment and Anti-tuberculosis Therapy Outcomes in Brazil Between 2015 and 2022: A Nationwide Study.

Author

Barreto-Duarte, Beatriz, Villalva-Serra, Klauss, Miguez-Pinto, João P, Araújo-Pereira, Mariana, Campos, Vanessa M S, Rosier, Gabriela, Nogueira, Betânia M F, Queiroz, Artur T L, Rolla, Valeria C, Cordeiro-Santos, Marcelo, Kritski, Afrânio L, Martinez, Leonardo, Rebeiro, Peter F, Sterling, Timothy R, Rodrigues, Moreno M, and Andrade, Bruno B

Subjects
PATIENT compliance, TREATMENT effectiveness, ODDS ratio, REGRESSION analysis, TUBERCULOSIS, DIRECTLY observed therapy
Abstract

Background Adherence to anti-tuberculosis treatment (ATT) in Brazil remains a challenge in achieving the goals set by the World Health Organization (WHO). Patients who are lost to follow-up during treatment pose a significant public health problem. This study aimed to investigate the factors associated with unfavorable ATT outcomes among those undergoing retreatment in Brazil. Methods We conducted an observational study of patients aged ≥18 years with tuberculosis (TB) reported to the Brazilian National Notifiable Disease Information System between 2015 and 2022. Clinical and epidemiologic variables were compared between the study groups (new cases and retreatment). Regression models identified variables associated with unfavorable outcomes. Results Among 743 823 reported TB cases in the study period, 555 632 cases were eligible, consisting of 462 061 new cases and 93 571 undergoing retreatments (44 642 recurrent and 48 929 retreatments after loss to follow-up [RLTFU]). RLTFU (odds ratio [OR], 3.96 [95% confidence interval {CI}, 3.83–4.1]) was a significant risk factor for any type of unfavorable ATT. Furthermore, RLTFU (OR, 4.93 [95% CI, 4.76–5.11]) was the main risk factor for subsequent LTFU. For death, aside from advanced age, living with HIV (OR, 6.28 [95% CI, 6.03–6.54]) was the top risk factor. Conclusions Retreatment is a substantial risk factor for unfavorable ATT outcomes, especially after LTFU. The rates of treatment success in RLTFU are distant from the WHO End TB Strategy targets throughout Brazil. These findings underscore the need for targeted interventions to improve treatment adherence and outcomes in persons who experience RLTFU. [ABSTRACT FROM AUTHOR]

Published
2024
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16. In-depth analysis of laboratory parameters reveals the interplay between sex, age, and systemic inflammation in individuals with COVID-19

Author

ten-Caten, Felipe, Gonzalez-Dias, Patrícia, Castro, Ícaro, Ogava, Rodrigo L.T., Giddaluru, Jeevan, Silva, Juan Carlo S., Martins, Felipe, Gonçalves, André N.A., Costa-Martins, André G., Araujo, José D., Viegas, Ana Carolina, Cunha, Fernando Q., Farsky, Sandra, Bozza, Fernando A., Levin, Anna S., Pannaraj, Pia S., de Silva, Thushan I., Minoprio, Paola, Pinheiro da Silva, Fabiano, Andrade, Bruno B., and Nakaya, Helder I.

Published
2021
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17. Novel stepwise approach to assess representativeness of a large multicenter observational cohort of tuberculosis patients: The example of RePORT Brazil

Author

Arriaga, María B., Amorim, Gustavo, Queiroz, Artur T.L., Rodrigues, Moreno M.S., Araújo-Pereira, Mariana, Nogueira, Betania M.F., Souza, Alexandra Brito, Rocha, Michael S., Benjamin, Aline, Moreira, Adriana S.R., de Oliveira, Jamile G., Figueiredo, Marina C., Turner, Megan M., Alves, Kleydson, Durovni, Betina, Lapa-e-Silva, José R., Kritski, Afrânio L., Cavalcante, Solange, Rolla, Valeria C., Cordeiro-Santos, Marcelo, Sterling, Timothy R., and Andrade, Bruno B.

Published
2021
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19. The effect of previous SARSCoV-2 infection on systemic immune responses in individuals with tuberculosis.

Author

Xavier, Mariana S., Araujo-Pereira, Mariana, de Oliveira, Quezia M., Sant’Anna, Flavia M., Ridolfi, Felipe M., de Andrade, Alice M. S., Figueiredo, Marina C., Sterling, Timothy R., Gordhan, Bhavna G., Kana, Bavesh D., Andrade, Bruno B., Rolla, Valeria C., and Gomes-Silva, Adriano

Subjects
IMMUNE response, MYCOBACTERIUM tuberculosis, TUBERCULOSIS, SYMPTOMS, INFECTION
Abstract

Background: The impact of previous SARS-CoV-2 infection on the systemic immune response during tuberculosis (TB) disease has not been explored. Methods: An observational, cross-sectional cohort was established to evaluate the systemic immune response in persons with pulmonary tuberculosis with or without previous SARS-CoV-2 infection. Those participants were recruited in an outpatient referral clinic in Rio de Janeiro, Brazil. TB was defined as a positive Xpert-MTB/RIF Ultra and/or a positive culture of Mycobacterium tuberculosis from sputum. Stored plasma was used to perform specific serology to identify previous SARS-CoV-2 infection (TB/Prex-SCoV-2 group) and confirm the noninfection of the tuberculosis group (TB group). Plasmatic cytokine/chemokine/ growth factor profiling was performed using Luminex technology. Tuberculosis severity was assessed by clinical and laboratory parameters. Participants from TB group (4.55%) and TB/Prex-SCoV-2 (0.00%) received the complete COVID19 vaccination. Results: Among 35 participants with pulmonary TB, 22 were classified as TB/ Prex-SCoV-2. The parameters associated with TB severity, together with hematologic and biochemical data were similar between the TB and TB/PrexSCoV-2 groups. Among the signs and symptoms, fever and dyspnea were significantly more frequent in the TB group than the TB/Prex-SCoV-2 group (p < 0,05). A signature based on lower amount of plasma EGF, G-CSF, GM-CSF, IFN-a2, IL-12(p70), IL-13, IL-15, IL-17, IL-1b, IL-5, IL-7, and TNF-b was observed in the TB/Prex-SCoV-2 group. In contrast, MIP-1b was significantly higher in the TB/Prex-SCoV-2 group than the TB group. Conclusion: TB patients previously infected with SARS-CoV-2 had an immunomodulation that was associated with lower plasma concentrations of soluble factors associated with systemic inflammation. This signature was associated with a lower frequency of symptoms such as fever and dyspnea but did not reflect significant differences in TB severity parameters observed at baseline. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Characteristics of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome and its influence on tuberculosis treatment outcomes in persons living with HIV

Author

Narendran, Gopalan, Jyotheeswaran, Keerthana, Senguttuvan, Thirumaran, Vinhaes, Caian L., Santhanakrishnan, Ramesh K., Manoharan, Tamizhselvan, Selvaraj, Anbhalagan, Chandrasekaran, Padmapriyadarsini, Menon, Pradeep A., Bhavani, Kannabiran P., Reddy, Devarajulu, Narayanan, Ravichandran, Subramanyam, Balaji, Sathyavelu, Sekhar, Krishnaraja, Raja, Kalirajan, Pownraj, Angamuthu, Dhanalakshmi, Susaimuthu, Stella Mary, Ganesan, Ranjit R.K., Tripathy, Srikanth P., Swaminathan, Soumya, and Andrade, Bruno B.

Published
2020
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23. Polymorphisms in interferon pathway genes and risk of Mycobacterium tuberculosis infection in contacts of tuberculosis cases in Brazil

Author

Cubillos-Angulo, Juan Manuel, Arriaga, María B., Melo, Mayla G.M., Silva, Elisangela C., Alvarado-Arnez, Lucia Elena, de Almeida, Alexandre S., Moraes, Milton O., Moreira, Adriana S.R., Lapa e Silva, Jose R., Fukutani, Kiyoshi F., Sterling, Timothy R., Hawn, Thomas R., Kritski, Afrânio L., Oliveira, Martha M., and Andrade, Bruno B.

Published
2020
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28. The role of ESAT-6 in tuberculosis immunopathology.

Author

Passos, Beatriz B. S., Araújo-Pereira, Mariana, Vinhaes, Caian L., Amaral, Eduardo P., and Andrade, Bruno B.

Subjects
IMMUNOPATHOLOGY, TUBERCULOSIS, MYCOBACTERIUM tuberculosis, DISEASE progression, IMMUNE system
Abstract

Despite major global efforts to eliminate tuberculosis, which is caused by Mycobacterium tuberculosis (Mtb), this disease remains as a major plague of humanity. Several factors associated with the host and Mtb interaction favor the infection establishment and/or determine disease progression. The Early Secreted Antigenic Target 6 kDa (ESAT-6) is one of the most important and well-studied mycobacterial virulence factors. This molecule has been described to play an important role in the development of tuberculosis-associated pathology by subverting crucial components of the host immune responses. This review highlights the main effector mechanisms by which ESAT-6 modulates the immune system, directly impacting cell fate and disease progression. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Prediction Models for Adverse Drug Reactions During Tuberculosis Treatment in Brazil.

Author

Ridolfi, Felipe, Amorim, Gustavo, Peetluk, Lauren S, Haas, David W, Staats, Cody, Araújo-Pereira, Mariana, Cordeiro-Santos, Marcelo, Kritski, Afrânio L, Figueiredo, Marina C, Andrade, Bruno B, Rolla, Valeria C, Sterling, Timothy R, and Consortium, for the Regional Prospective Observational Research in Tuberculosis (RePORT)–Brazil

Abstract

Background Tuberculosis (TB) treatment–related adverse drug reactions (TB-ADRs) can negatively affect adherence and treatment success rates. Methods We developed prediction models for TB-ADRs, considering participants with drug-susceptible pulmonary TB who initiated standard TB therapy. TB-ADRs were determined by the physician attending the participant, assessing causality to TB drugs, the affected organ system, and grade. Potential baseline predictors of TB-ADR included concomitant medication (CM) use, human immunodeficiency virus (HIV) status, glycated hemoglobin (HbA1c), age, body mass index (BMI), sex, substance use, and TB drug metabolism variables (NAT2 acetylator profiles). The models were developed through bootstrapped backward selection. Cox regression was used to evaluate TB-ADR risk. Results There were 156 TB-ADRs among 102 of the 945 (11%) participants included. Most TB-ADRs were hepatic (n = 82 [53%]), of moderate severity (grade 2; n = 121 [78%]), and occurred in NAT2 slow acetylators (n = 62 [61%]). The main prediction model included CM use, HbA1c, alcohol use, HIV seropositivity, BMI, and age, with robust performance (c-statistic = 0.79 [95% confidence interval {CI},.74–.83) and fit (optimism-corrected slope and intercept of −0.09 and 0.94, respectively). An alternative model replacing BMI with NAT2 had similar performance. HIV seropositivity (hazard ratio [HR], 2.68 [95% CI, 1.75–4.09]) and CM use (HR, 5.26 [95% CI, 2.63–10.52]) increased TB-ADR risk. Conclusions The models, with clinical variables and with NAT2 , were highly predictive of TB-ADRs. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Transient Hearing Loss in Adults Associated With Zika Virus Infection

Author

Vinhaes, Eriko S., Santos, Luciane A., Dias, Lislane, Andrade, Nilvano A., Bezerra, Victor H., de Carvalho, Anderson T., de Moraes, Laise, Henriques, Daniele F., Azar, Sasha R., Vasilakis, Nikos, Ko, Albert I., Andrade, Bruno B., Siqueira, Isadora C., Khouri, Ricardo, and Boaventura, Viviane S.

Published
2017

37. Differential expression of polyamine biosynthetic pathways in skin lesions and in plasma reveals distinct profiles in diffuse cutaneous leishmaniasis

Author

Malta-Santos, Hayna, França-Costa, Jaqueline, Macedo, Amanda, Queiroz, Artur T. L., Fukutani, Kiyoshi F., Muxel, Sandra Marcia, Khouri, Ricardo, Van Weyenbergh, Johan, Boaventura, Viviane, Barral, Aldina, Costa, Jackson M., Floh, Eny Iochevet Segal, Andrade, Bruno B., Floeter-Winter, Lucile M., and Borges, Valéria M.

Published
2020
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40. Isoniazid Monoresistance and Antituberculosis Treatment Outcome in Persons With Pulmonary Tuberculosis in Brazil.

Author

Araújo-Pereira, Mariana, Arriaga, María B, Carvalho, Anna Cristina C, Spener-Gomes, Renata, Schmaltz, Carolina A S, Nogueira, Betânia M F, Figueiredo, Marina C, Turner, Megan M, Cordeiro-Santos, Marcelo, Rolla, Valeria C, Sterling, Timothy R, Andrade, Bruno B, Kritski, Afrânio L, and Consortium, for the Regional Prospective Observational Research for Tuberculosis (RePORT)-Brazil

Subjects
TUBERCULOSIS, ISONIAZID, TREATMENT effectiveness, LOGISTIC regression analysis, ODDS ratio
Abstract

Background The high burden of drug-resistant tuberculosis (TB) is a problem to achieve the goals of the End TB Strategy by 2035. Whether isoniazid monoresistance (Hr) affects anti-TB treatment (ATT) outcomes remains unknown in high-burden countries. Methods We evaluated determinants of ATT outcome among pulmonary TB cases reported to the National Notifiable Disease Information System (SINAN) between June 2015 and June 2019, according to drug sensitivity testing (DST) results. Binomial logistic regression models were employed to evaluate whether Hr was associated with an unfavorable ATT outcome: death or failure, compared to cure or treatment completion. Results Among 60 804 TB cases reported in SINAN, 21 197 (34.9%) were included in the study. In this database, the frequency of unfavorable outcomes was significantly higher in those with Hr in contrast to isoniazid-sensitive persons with pulmonary TB (9.1% vs 3.05%; P <.001). Using a binomial logistic regression model, Hr was independently associated with unfavorable outcomes (odds ratio, 3.34 [95% confidence interval, 2.06–5.40]; P <.001). Conclusions Hr detected prior to ATT was predictive of unfavorable outcomes at the national level in Brazil. Our data reinforce the need for high-TB-burden countries to prioritize DST to detect Hr. Effective treatment regimens for Hr-TB are needed to improve outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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42. Inflammation and Change in Body Weight With Antiretroviral Therapy Initiation in a Multinational Cohort of HIV-Infected Adults

Author

ACTG PEARLS, NWCS 319 Study Team, Mave, Vidya, Erlandson, Kristine M., Gupte, Nikhil, Balagopal, Ashwin, Asmuth, David M., Campbell, Thomas B., Smeaton, Laura, Kumarasamy, Nagalingeswaran, Hakim, James, Santos, Breno, Riviere, Cynthia, Hosseinipour, Mina C., Sugandhavesa, Patcharaphan, Infante, Rosa, Pillay, Sandy, Cardoso, Sandra W., Tripathy, Srikanth, Mwelase, Noluthando, Berendes, Sima, Andrade, Bruno B., Thomas, David L., Bollinger, Robert C., and Gupta, Amita

Published
2016

50. Molecular degree of perturbation of plasma inflammatory markers associated with tuberculosis reveals distinct disease profiles between Indian and Chinese populations

Author

Oliveira-de-Souza, Deivide, Vinhaes, Caian L., Arriaga, Maria B., Kumar, Nathella Pavan, Cubillos-Angulo, Juan M., Shi, Ruiru, Wei, Wang, Yuan, Xing, Zhang, Guolong, Cai, Ying, Barry, III, Clifton E., Via, Laura E., Sher, Alan, Babu, Subash, Mayer-Barber, Katrin D., Nakaya, Helder I., Fukutani, Kiyoshi F., and Andrade, Bruno B.

Published
2019
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